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Artigo Revisado por pares

Vincent Mor, Martha Z. Stalker, Richard J. Gralla, Howard I. Scher, Claudia Cimma, Donna Park, Anne Marie C. Flaherty, Margaret E. Kiss, Paul N. Nelson, Linda Laliberte, Rachel Schwartz, Paul A. Marks, Herbert F. Oettgen,

A stratified, random-assignment trial of 442 cancer patients was conducted to evaluate medical, psychosocial, and financial outcomes of day hospital treatment as an alternative to inpatient care for certain cancer patients. Eligible patients required: a 4- to 8-hour treatment plan, including chemotherapy and other long-term intravenous (i.v.) treatment; a stable cardiovascular status; mental competence; no skilled overnight nursing; and a helper to assist with home care. Patients were ineligible ...

Tópico(s): Family and Patient Care in Intensive Care Units

1988 - Elsevier BV | Journal of Clinical Epidemiology

Revisão Acesso aberto Revisado por pares

B. Lee Peterlin, Simona Sacco, Claudia Bernecker, I Scher,

Background Migraine is comorbid with obesity. Recent research suggests an association between migraine and adipocytokines, proteins that are predominantly secreted from adipose tissue and which participate in energy homeostasis and inflammatory processes. Objectives In this review, we first briefly discuss the association between migraine and obesity and the importance of adipose tissue as a neuroendocrine organ. We then present a systematic review of the extant literature evaluating circulating ...

Tópico(s): Nicotinic Acetylcholine Receptors Study

2016 - Wiley | Headache The Journal of Head and Face Pain

Revisão Acesso aberto Revisado por pares

Klaus Pantel, Claudia Hille, Howard I. Scher,

Abstract BACKGROUND Prostate cancer represents the most common non–skin cancer type in men. Unmet needs include understanding prognosis to determine when intervention is needed and what type, prediction to guide the choice of a systemic therapy, and response indicators to determine whether a treatment is working. Over the past decade, the “liquid biopsy,” characterized by the analysis of tumor cells and tumor cell products such as cell-free nucleic acids (DNA, microRNA) or extracellular vesicles circulating ...

Tópico(s): Cancer Genomics and Diagnostics

2019 - American Association for Clinical Chemistry | Clinical Chemistry

Artigo Acesso aberto Revisado por pares

Ben Jackson, Maciej F. Boni, Matthew Bull, Amy Colleran, Rachel Colquhoun, Alistair C. Darby, Sam Haldenby, Verity Hill, Anita O. Lucaci, John T. McCrone, Samuel M. Nicholls, Áine O’Toole, Nicole Pacchiarini, Radoslaw Poplawski, Emily Scher, Flora Todd, Hermione J. Webster, Mark Whitehead, Claudia Wierzbicki, Nicholas J. Loman, Thomas R. Connor, David L. Robertson, Oliver G. Pybus, Andrew Rambaut,

We present evidence for multiple independent origins of recombinant SARS-CoV-2 viruses sampled from late 2020 and early 2021 in the United Kingdom. Their genomes carry single-nucleotide polymorphisms and deletions that are characteristic of the B.1.1.7 variant of concern but lack the full complement of lineage-defining mutations. Instead, the remainder of their genomes share contiguous genetic variation with non-B.1.1.7 viruses circulating in the same geographic area at the same time as the recombinants. ...

Tópico(s): Animal Virus Infections Studies

2021 - Cell Press | Cell

Artigo Acesso aberto Revisado por pares

Clara Scher, Sophie Crawley, Claudia Cooper, Elizabeth L Sampson, Kirsten Moore,

Many carers of individuals with dementia experience high levels of grief before and after the death of the person with dementia. This study aimed to determine the usefulness, acceptability, and relevance of an animation developed to raise awareness to grief experienced by carers of people with dementia.This research had a cross-sectional survey design. We contacted carers of people with dementia over the phone or email. Participants evaluated the animation through an online or paper-based survey. ...

Tópico(s): Dementia and Cognitive Impairment Research

2021 - SAGE Publishing | Dementia

Artigo Revisado por pares

Maxwell Scher, Claudia I. Cabrera, Yida Cai, Akina Tamaki, Shawn Li, Nicole Fowler, Rod Rezaee, Pierre Lavertu, Theodoros N. Teknos, Jason E. Thuener,

Objective: The objective of this study is to investigate the safety, efficacy, and potential cost-savings of the outpatient parotidectomy procedure. Methods: This is a retrospective chart review of all patients who underwent a parotidectomy at a large academic center from 2015 through 2019 including demographic data, postoperative complications, drain placement, readmission, and financial cost. A comparison was performed between patients who underwent an outpatient vs inpatient parotidectomy. Results: ...

Tópico(s): Oral and Maxillofacial Pathology

2021 - SAGE Publishing | Annals of Otology Rhinology & Laryngology

Editorial Acesso aberto Revisado por pares

Adam F. Stewart, Donna M. Ferriero, S. Andrew Josephson, Daniel H. Lowenstein, Robert O. Messing, Jorge R. Oksenberg, S. Claiborne Johnston, Stephen L. Hauser,

... Scharfman, Helen Scheffer, Ingrid Scheltens, Philip Schenck, C. Scher, Mark Scherer, Steven Scherzer, Clemens Schlachetzki, Felix Schlaepfer, ... Yuen Sola, Augusto Soliven, Betty Soltesz, I. Sommer, Claudia Sorond, Farzaneh Sotelo, Constantino Soto, Claudio Sperling, Reisa ... Klaus Trapp, Bruce Traynor, Bryan Tremlett, Helen Trenkwalder, Claudia Trojano, Maria Tuhrim, Stanley Turan, Tanya Tuszynski, Mark ... Jun Chetelat, Gael Chiba, K. Chinnery, Patrick Chiriboga, Claudia Chitnis, Tanuja Choi, Doo-Sup Cilio, Maria Roberta ...

Tópico(s): Mental Health Research Topics

2012 - Wiley | Annals of Neurology

Artigo

Maura Marcucci, Thomas Painter, David Conen, В. В. Ломиворотов, Daniel I. Sessler, Matthew T.V. Chan, Flávia K. Borges, Kate Leslie, Emmanuelle Duceppe, María José Martínez‐Zapata, Chew Yin Wang, Denis Xavier, Sandra Ofori, Michael Ke Wang, Sergey Efremov, Giovanni Landoni, Ydo V. Kleinlugtenbelt, Wojciech Szczeklik, Denis Schmartz, Amit X. Garg, Timothy G. Short, Mária Wittmann, Christian S. Meyhoff, Mohammed Amir, David Torres, Ameen Patel, Kurt Ruetzler, Joel L. Parlow, Vikas Tandon, Edith Fleischmann, Carísi Anne Polanczyk, André Lamy, Raja Jayaram, Sergey V. Astrakov, William Ka Kei Wu, Chao Chia Cheong, Sabry Ayad, М. Yu. Кirov, Miriam de Nadal, В. В. Лихванцев, Pilar Paniagua, Héctor J. Hernández, Kamal Maheshwari, Richard Whitlock, Michael McGillion, Jessica Vincent, Ingrid Copland, Kumar Balasubramanian, Bruce Biccard, Sadeesh Srinathan, Samandar Ismoilov, Shirley Pettit, David Stillo, Andrea Kurz, Emilie P. Belley‐Côté, Jessica Spence, William F. McIntyre, Shrikant I. Bangdiwala, Gordon Guyatt, Salim Yusuf, P.J. Devereaux, Maura Marcucci, Thomas Painter, David Conen, В. В. Ломиворотов, Daniel I. Sessler, Matthew T.V. Chan, Flávia K. Borges, Kate Leslie, Emmanuelle Duceppe, María José Martínez‐Zapata, Chew Yin Wang, Denis Xavier, Sandra Ofori, Michael Ke Wang, Sergey Efremov, Giovanni Landoni, Ydo V. Kleinlugtenbelt, Wojciech Szczeklik, Denis Schmartz, Timothy G. Short, Mária Wittmann, Christian S. Meyhoff, Mohammed Amir, David Torres, Ameen Patel, Kurt Ruetzler, Joel L. Parlow, Vikas Tandon, Carísi Anne Polanczyk, Raja Jayaram, Sergey V. Astrakov, Sabry Ayad, М. Yu. Кirov, Miriam de Nadal, Pilar Paniagua, Héctor J. Hernández, Kamal Maheshwari, Michael McGillion, Jessica Vincent, Ingrid Copland, Kumar Balasubramanian, Sadeesh Srinathan, David Stillo, Andrea Kurz, Emilie P. Belley‐Côté, Jessica Spence, Shrikant I. Bangdiwala, Gordon Guyatt, Salim Yusuf, P.J. Devereaux, Toby Richards, John W. Eikelboom, Chaoran Wu, Peter L Gross, Pavel S Roshanov, Ian Roberts, Dean Fergusson, Pierre Foëx, Finlay A. McAlister, S. Diodato, Rosemary Howe, Hannah Bruce Macdonald, Louise Mastrangelo, Clare McGall, Natalie Mercuri, Sarah Molnar, Trisha Southall, Jennifer Swanson, Makayla Tosh, Eric Deng, Tamara Marsden, Mark Molec, Olga Shestakovska, Robin Zhao, Mikhail Yadgarov, D. Borisov, John G. Gorman, Teresa Cafaro, Stefano Italiano, Andrés Valenzuela Suárez, Steffen Blum, Nuria Ruiz-López, Christian E. Haarmark Nielsen, Anna Włudarczyk, Federico Germini, Javiera Paz Vasquez, L.J. Bleijerveen, Stefan Schandelmaier, Jesse Popov, Daniél V. Møller, Carlos Moliner Abós, Denis Losik, Arnav Agarwal, Chantal Mulkens, Е. Н. Фишер, Paweł Wrona, Martin Šrámek, Steffan Frosi Stella, Antonia Nucera, Franziska Kuestermann, Emmanuel E. Egom, Shaan Gupta, Luis E. Morillo, Alexander Thiel, Gillian D Ormond, Louise de Prinse, Sam Lumb, S. Macklin, Christine S. Osborn, Johanna Somfleth, Carolyn M. Wood, David Highton, Palvannan Sivalingam, Allison Kearney, Sabrina Oishi, V. Forrester, Edward Pilling, Sibi Mathew-Kurian, Joanne Cummins, Juanita Muller, Surbhi Malhotra, Lucy Glazov, D. J. Wright, Michael H Bennett, Priscilla Marneros, Steve Cai, Natalie Pfund, Michael J. Challis, David Alcock, Robyn A. Seale, David Bramley, Joshua Szental, Justin Yeung, Miriam Towns, Kerry Gill, Samantha Bates, Sarah R. Bowman, Amos Moody, Paul Slocomb, Peter Smedley, James Marckwald, Ross Kerridge, Paul J. Healey, J. Douglas, Bernard D. Frost, Libia E. Machado Muñoz, Sue Chew, Andrea Barton, Amy Skiller, Sarah Boschen, Richard Bulach, Tina Maggio, Lauren Bulfin, Philip J. Peyton, Justin Nazareth, S. Baulch, Saskia Harris, Gayle Claxton, Bernhard Riedel, Kimberley Coleman, Jason P. Koerber, Adam Badenoch, Susan M Rattigan, V. Scotland, Helen Vlachtsis, Tomás Corcoran, Andrew J. Toner, Nigel Dunk, Ned Douglas, Amit Surah, Vi Ha, Alfred Tanaka Mahumani, Jennifer R. Cope, Elenore Clark-MacKay, Edith Fleischmann, Barbara Kabon, Christian Reiterer, Alexander Taschner, Nikolas Adamowitsch, Oliver Zotti, Seyed Javad Bidgoli, Christiane Dzechi, C. Van Lerberghe, Hélène Besse, Ida Stany, Mona Momeni, Audrey Dieu, Benoit Loic, Ricardo Reinaldo Bergo, Frederico Dall’Orto, Gislayne R. Ribeiro, Keyla C. Bitencourt, Luciana Paula Cadore Stefani, Rosângela da Rosa Minuzzi, André P. Schmidt, Debora Roberta Dornelles, M Brandao, Kelly Lawrence, Philip Joseph, Patrick Magloire, Amna Ahmed, Conor Cox, Krysten Gregus, Baha Alazzoni, Jacquie Hare, Dale Williams, Dan Tushinski, Samir Raza, Shariq Haider, Amitabha Chakroborty, Shervin Zandi, Ahraaz Wyne, Jessica Huynh, Amanda Huynh, Tomas VanHelder, Susan G. O’Leary, John Harlock, Mohamed Panju, Kajenny Srivaratharajan, Betty Chui, Ryan Proc, Lisa Trombetta, T Rapanos, Shirley Pettit, Harsha Shanthanna, John Neary, Katie Connolly, Muammar Abdulrahman, Spencer Wikkerink, Faraaz Quraishi, Rahima Nenshi, Deborah DuMerton, Jason Erb, Jessica Shelley, Elorm Vowotor,

Among patients having noncardiac surgery, perioperative hemodynamic abnormalities are associated with vascular complications. Uncertainty remains about what intraoperative blood pressure to target and how to manage long-term antihypertensive medications perioperatively.To compare the effects of a hypotension-avoidance and a hypertension-avoidance strategy on major vascular complications after noncardiac surgery.Partial factorial randomized trial of 2 perioperative blood pressure management strategies ( ...

American College of Physicians

Artigo Acesso aberto Revisado por pares

Wilma F. Bergfeld, Antonellá Tosti, Raymond M. Fertig, Jerry Shapiro, Adam I. Rubin, Jessica S. Haber, Manasmon Chairatchaneeboon, Fatih Göktay, Pembegül Güneş, Emre Kaynak, Şirin Yaşar, Zafer Küçükodacı, Sema Aytekin, Gabriella Fabbrocini, Claudio Marasca, Giuseppe Monfrecola, Matteo Megna, Riccardo Balestri, Giulia Rech, Carlo Renè Girardelli, Bianca Maria Piraccini, M. La Plaça, Ramón Grimalt, Tudor Pinteala, Anca Chiriac, Leandro Fonseca Noriega, Nilton Di Chiacchio, Nilton Gióia Di Chiacchio, Flávia Cury Rezende, Anca Chiriac, Irina Roșca, Francesca Larese Filon, Mariana Pinteala, Cristian Podoleanu, Simona Stolnicu, Marius Florin Coroş, Adina Coroabă, Alexander Katoulis, Aikaterini I. Liakou, Dimitris Rigopoulos, Dimitra Daskari, Evangelia Bozi, Dimitra Lianou, Robert Baran, V. Sibaud, Miruna Negulescu, Slimane Zerdoud, S. Boulinguez, É. Tournier, Jean‐Pierre Delord, Alexander Katoulis, Dimitrios Sgouros, Aikaterini I. Liakou, Evangelia Bozi, Dimitrios Rigopoulos, Konstantina Diamanti, Antigoni Alevizou, Vasileia Damaskou, Ioannis Panayiotides, Εfstathios Rallis, George Aravanis, Paraskevi-Aikaterini Pierrakou, Chariklia Spiliadi, Letícia Arsie Contin, Leandro Fonseca Noriega, Elisa Raquel Martins da Costa Marques, Pierre Halteh, Richard K. Scher, Shari R. Lipner, Amanda Artis, Claudia Cavallotti, Maria Mariano, Norma Cameli, Luca Muscardin, Luiza Alonso Pereira, Maíra Rochael, Maria Fernanda Reis Gavazzoni‐Dias, Marcelo Lucchesi Teixeira, Jhessica Andrade, Giselle Martins Pinto, Leandro Damiani, Fernanda Musa Aguiar, Mariana Vale Scribel da Silva, Mariya Miteva, Bruna Duque‐Estrada, Ana Letícia Boff, Celso Tavares Sodré, Rodrigo Pirmez, Dâmia Leal Vendramini, Bruno R.L. Silveira, Jon Holmes, Antonellá Tosti, Adam S. Aldahan, L Chen, Raymond M. Fertig, Vidhi Shah, Stephanie Mlacker, Vincent M. Hsu, Keyvan Nouri, Richard K. Scher, Pierre Halteh, Cynthia M. Magro, Shari R. Lipner, Mengensatzproduktion, Druckerei Stückle, Druckerei Stückle,

2016 - | Skin Appendage Disorders

Carta Acesso aberto Revisado por pares

Aditya Karandikar, Agnieszka O. Solberg, Alice Fung, Amie Y. Lee, Amina Farooq, Amy Taylor, Amy Oliveira, Anand K. Narayan, Andi Senter, Aneesa Majid, Angela Tong, Anika L. McGrath, Anjali Malik, Ann L. Brown, Anne C. Roberts, Arthur C. Fleischer, Beth Vettiyil, Beth Zigmund, Brian Park, Bruce Curran, Cameron Henry, Camilo Jaimes, Cara Connolly, Caroline D. Robson, Carolyn C. Meltzer, Catherine H. Phillips, Christine Dove, Christine M. Glastonbury, Christy B. Pomeranz, Claudia Kirsch, Constantine M. Burgan, Courtney Scher, Courtney M. Tomblinson, Cristina Fuss, Cynthia Santillan, Dania Daye, Daniel B. Brown, Daniel J. Young, Daniel B. Kopans, Daniel Vargas, Dann Martin, D. J. Thompson, David W. Jordan, Deborah R. Shatzkes, Derek Sun, Domenico Mastrodicasa, Elainea N. Smith, Elena Korngold, Elizabeth H. Dibble, Elizabeth Kagan Arleo, Elizabeth M. Hecht, Elizabeth A. Morris, Elizabeth P. Maltin, Erin A. Cooke, Erin Simon Schwartz, Evan Lehrman, Faezeh Sodagari, Shah Faisal, Florence X. Doo, Francesca Rigiroli, George K. Vilanilam, Gina Landinez, Grace Gwe-Ya Kim, Habib Rahbar, Hailey H. Choi, Harmanpreet Bandesha, Haydee Ojeda‐Fournier, Ichiro Ikuta, I. Dragojević, Jamie Lee Twist Schroeder, Jana Ivanidze, Janine Katzen, Jason Chiang, Jeffers Nguyen, Jeffrey D. Robinson, Jennifer C. Broder, Jennifer Kemp, Jennifer S. Weaver, Jesse M. Conyers, Jessica B. Robbins, Jessica R. Leschied, Jessica Wen, Jocelyn Park, John Mongan, Jordan D. Perchik, José Pablo Martínez Barbero, Jubin Jacob, Karyn A. Ledbetter, Katarzyna J. Macura, Katherine E. Maturen, Katherine Frederick-Dyer, Katia Dodelzon, Kayla Cort, Kelly Kisling, Kemi Babagbemi, Kevin C. McGill, Kevin J. Chang, Kimberly Feigin, Kimberly S. Winsor, Kimberly Seifert, Kirang Patel, Kristin K. Porter, Kristin Foley, Krupa Patel-Lippmann, Lacey J. McIntosh, Laura Padilla, Lauren K. Groner, Lauren M. Harry, Lauren M. Ladd, Lisa Wang, Lucy B. Spalluto, M. Mahesh, M. Victoria Marx, Mark Sugi, Marla B. K. Sammer, Maryellen Sun, Matthew J. Barkovich, Matthew J. Miller, Maya Vella, Melissa A. Davis, Meridith J. Englander, Michael Durst, Michael Oumano, Monica J. Wood, Morgan P. McBee, Nancy J. Fischbein, Nataliya Kovalchuk, Neil Lall, Neville Eclov, Nikhil Madhuripan, Nikki S. Ariaratnam, Nina S. Vincoff, Nishita Kothary, Noushin Yahyavi‐Firouz‐Abadi, Olga R. Brook, Orit A. Glenn, Pamela K. Woodard, Parisa Mazaheri, Patricia Rhyner, Peter R. Eby, Preethi Raghu, Rachel F. Gerson, Rina Patel, Robert L. Gutierrez, Robyn Gebhard, Rochelle F. Andreotti, Rukya Masum, Ryan Woods, Sabala Mandava, Samantha G. Harrington, Samir Parikh, Sammy Chu, Sandeep Arora, Sandra M. Meyers, Sanjay P. Prabhu, Sara Shams, Sarah K. Pittman, S. Patel, Shelby Payne, Steven W. Hetts, Tarek A. Hijaz, Teresa Chapman, Thomas W. Loehfelm, Titania Juang, Toshimasa Clark, Valeria Potigailo, Vinil Shah, Virginia B. Planz, Vivek Kalia, Wendy B. DeMartini, William P. Dillon, Yasha Gupta, Yilun Koethe, Zachary Hartley-Blossom, Zhen J. Wang, Geraldine McGinty, Adina Haramati, Laveil M. Allen, Pauline Germaine,

... MD, PhD Christopher Murphy, MD Christy Pomeranz, MD Claudia F.E. Kirsch, MD, PhD Cody Quirk, MD Constantine M. Burgan, MD Courtney Scher, DO Courtney Tomblinson, MD Cristina Fuss, MD Cynthia ...

Tópico(s): Medical Malpractice and Liability Issues

2022 - Elsevier BV | Clinical Imaging

Artigo Revisado por pares

S. Joseph Wright‬, Carel P. van Schaik,

... Chantal D. Reid, Kyle C. Rodman, C. Lane Scher, Harald Schmidt Van Marle, Barbara Seget, Shubhi Sharma, ... de Oliveira Wadt, Carolina Volkmer de Castilho, Ana Cláudia Lira-Guedes, Patricia da Costa, Fernanda Lopes da ...

Tópico(s): Animal and Plant Science Education

1994 - University of Chicago Press | The American Naturalist

Artigo Acesso aberto Revisado por pares

Daniel Nava Rodrigues, Pasquale Rescigno, David Liu, Wei Yuan, Suzanne Carreira, Maryou Lambros, George Seed, Joaquı́n Mateo, Ruth Riisnaes, Stephanie A. Mullane, Claire A. Margolis, Diana Miao, Susana Miranda, David Dolling, Matthew Clarke, Cláudia Bertan, Mateus Crespo, Gunther Boysen, Ana Ferreira, Adam Sharp, Ines Figueiredo, Daniel Keliher, Saud H. AlDubayan, Kelly P. Burke, Semini Sumanasuriya, Mariane Fontes, Diletta Bianchini, Zafeiris Zafeiriou, Larissa Sena Teixeira Mendes, Kent W. Mouw, Michael T. Schweizer, Colin C. Pritchard, Stephen J. Salipante, Mary‐Ellen Taplin, Himisha Beltran, Mark A. Rubin, Marcin Cieślik, Dan R. Robinson, E. Heath, Nikolaus Schultz, Joshua Armenia, Wassim Abida, Howard I. Scher, Christopher J. Lord, Alan D. D’Andrea, Charles L. Sawyers, Arul M. Chinnaiyan, Andrea Alimonti, Peter S. Nelson, Charles G. Drake, Eliezer M. Van Allen, Johann S. de Bono,

BACKGROUND. Understanding the integrated immunogenomic landscape of advanced prostate cancer (APC) could impact stratified treatment selection.

Tópico(s): Cancer Genomics and Diagnostics

2018 - American Society for Clinical Investigation | Journal of Clinical Investigation

Capítulo de livro Acesso aberto

Richard D. Norris, Paul A. Wilson, Peter Blum, Annick Fehr, Claudia Agnini, André Bornemann, Slah Boulila, Paul R. Bown, C. Cournède, Oliver Friedrich, Amit K. Ghosh, Christopher J. Hollis, Pincelli M. Hull, Kyoung‐nam Jo, Christopher K. Junium, Masanori Kaneko, Diederik Liebrand, Peter C. Lippert, Z. Liu, Hiroki Matsui, Kazuyoshi Moriya, Hiroshi Nishi, Bradley N. Opdyke, Donald E. Penman, Brian W. Romans, Howie D. Scher, Philip F. Sexton, Haruka Takagi, Sandra Kirtland Turner, Jessica H. Whiteside, Tatsuhiko Yamaguchi, Yuhji Yamamoto,

Integrated Ocean Drilling Program Expedition 342 was designed to recover Paleogene sedimentary sequences with unusually high deposition rates across a wide range of water depths (Sites U1403-U1411).The drilling area is positioned to capture sedimentary and geochemical records of ocean chemistry and overturning circulation beneath the flow of the Deep Western Boundary Current in the northwest Atlantic Ocean.In addition, two operational days were dedicated to a sea trial of the Motion Decoupled Hydraulic ...

Tópico(s): Geological formations and processes

2014 - | Proceedings of the Integrated Ocean Drilling Program. Expedition reports/Proceedings of the Integrated Ocean Drilling Program

Artigo Acesso aberto Revisado por pares

Nora L. Springer, Neil M. Iyengar, Rohan Bareja, Akanksha Verma, Maxine S. Jochelson, Dilip D. Giri, Xi Kathy Zhou, Olivier Elemento, Andrew J. Dannenberg, Claudia Fischbach,

... Pollak M. Laudone V.P. Hudis C.A. Scher H.I. Scardino P.T. Eastham J.A. ...

Tópico(s): Adipose Tissue and Metabolism

2019 - Elsevier BV | American Journal Of Pathology

Artigo

Thushan I. de Silva, Guihai Liu, Benjamin B. Lindsey, Danning Dong, Shona C. Moore, Sharon Hsu, Dhruv R. Shah, Dannielle Wellington, Alexander J. Mentzer, Adrienn Angyal, Rebecca Brown, Matthew Parker, Zixi Ying, Xuan Yao, Lance Turtle, Susanna Dunachie, Mala K. Maini, Graham S. Ogg, Julian C. Knight, Yanchun Peng, Sarah L. Rowland-Jones, Tao Dong, David M. Aanensen, Khalil Abudahab, Helen Adams, Alexander Adams, Safiah Afifi, Dinesh Aggarwal, Shazaad S.Y. Ahmad, Louise Aigrain, Adela Alcolea-Medina, Nabil-Fareed Alikhan, Elias Allara, Roberto Amato, Tara Annett, Stephen Aplin, Cristina V. Ariani, Hibo Asad, Amy Ash, Paula Ashfield, Fiona Ashford, Laura Atkinson, Stephen W. Attwood, Cressida Auckland, Alp Aydin, David Baker, Paul Baker, Carlos E. Balcazar, Jonathan Ball, Jeffrey C. Barrett, Magdalena Barrow, Edward Barton, Matthew Bashton, Andrew R. Bassett, Rahul Batra, Chris Baxter, Nadua Bayzid, Charlotte Beaver, Angela H. Beckett, Shaun M. Beckwith, Luke Bedford, Robert Beer, Andrew D. Beggs, Katherine L. Bellis, Louise Berry, Beatrice Bertolusso, Angus Best, Emma Betteridge, David C. Bibby, Kelly Bicknell, Debbie Binns, Alec Birchley, Paul Bird, Chloe Bishop, Rachel Blacow, Victoria Blakey, Beth Blane, Frances Bolt, James Bonfield, Stephen Bonner, David Bonsall, Tim Boswell, Andrew Bosworth, Yann Bourgeois, Olivia Boyd, Declan T. Bradley, Cassie Breen, Catherine Bresner, Judith Breuer, Stephen Bridgett, Iraad F. Bronner, Ellena Brooks, Alice Broos, Julianne R. Brown, Giselda Bucca, Sarah L. Buchan, David Buck, Matthew Bull, Phillipa Burns, Shirelle Burton-Fanning, Timothy Byaruhanga, Matthew Byott, Stephen Campbell, Alessandro M. Carabelli, James S. Cargill, Matthew Carlile, Silvia Carvalho, Anna Casey, Anibolina Castigador, Jana Catalan, Vicki Chalker, Nicola J. Chaloner, Meera Chand, Joseph Chappell, Themoula Charalampous, Wendy Chatterton, Yasmin Chaudhry, Carol Churcher, Gemma Clark, Philip Clarke, Benjamin J. Cogger, Kevin D. Cole, Jennifer Collins, Rachel Colquhoun, Thomas R. Connor, Kate F. Cook, Jason D. Coombes, Sally Corden, Claire Cormie, Nicholas Cortes, Marius Cotic, Seb Cotton, Simon Cottrell, Lindsay Coupland, MacGregor Cox, Alison Cox, Noel Craine, Liam Crawford, Aidan Cross, Matthew Crown, Dorian Crudgington, Nicola Cumley, Tanya Curran, Martin D. Curran, Ana da Silva Filipe, Gavin Dabrera, Alistair C. Darby, Rose K. Davidson, Alisha Davies, Robert M. Davies, Thomas P. Davis, Daniela De Angelis, Elen De Lacy, Leonardo de Oliveira Martins, Johnny Debebe, Rebecca Denton-Smith, Samir Dervisevic, Rebecca Dewar, Jayasree Dey, Joana Dias, Donald Dobie, Matthew J. Dorman, Fatima Downing, Megan Driscoll, Louis du Plessis, Nichola Duckworth, Jillian Durham, Kirstine Eastick, Lisa J. Easton, Richard Eccles, Jonathan Edgeworth, Sue Edwards, Kate El Bouzidi, Sahar Eldirdiri, Nicholas Ellaby, Scott Elliott, Gary Eltringham, Leah Ensell, Michelle J. Erkiert, Marina Escalera Zamudio, Sarah Essex, Johnathan M. Evans, Cariad Evans, William V. Everson, Derek Fairley, Karlie Fallon, Arezou Fanaie, Ben W. Farr, Christopher Fearn, Theresa Feltwell, Lynne Ferguson, Laia Fina, Flavia Flaviani, Vicki M. Fleming, Stephen R. Forrest, Ebenezer Foster-Nyarko, Benjamin H. Foulkes, Luke Foulser, Mireille Fragakis, Dan Frampton, Sarah François, Christophe Fraser, Timothy M. Freeman, Helen Fryer, Marc Fuchs, William Fuller, Kavitha Gajee, Katerina Galai, Abbie Gallagher, Eileen Gallagher, Eileen Gallagher, Marta Gallis, Amy Gaskin, Bree Gatica-Wilcox, Lily Geidelberg, Matthew Gemmell, Iliana Georgana, Ryan P. George, Laura Gifford, Lauren Gilbert, Sophia T. Girgis, Sharon Glaysher, Emily J. Goldstein, Tanya Golubchik, Andrea N. Gomes, Sónia Gonçalves, Ian Goodfellow, Scott Goodwin, Salman Goudarzi, Marina Gourtovaia, Clive Graham, Lee Graham, Paul R. Grant, Luke R. Green, Angie Green, Jane Greenaway, Richard D. Gregory, Martyn F. Guest, Rory Gunson, Ravi Kumar Gupta, Bernardo Gutiérrez, Sam Haldenby, William L. Hamilton, Samantha E. Hansford, Tanzina Haque, Kathryn Harris, Ian Harrison, Ewan M. Harrison, Jennifer Hart, John A. Hartley, William T. Harvey, M J Harvey, Mohammed O. Hassan-Ibrahim, Judith Heaney, Thomas Helmer, John Henderson, Andrew R. Hesketh, Jessica Hey, David Heyburn, Ellen E. Higginson, Verity Hill, Jack D. Hill, Rachel A. Hilson, Ember Hilvers, Matthew T. G. Holden, Amy Hollis, Christopher W. Holmes, Nadine Holmes, Alison Holmes, Richard Hopes, Hailey Hornsby, Myra Hosmillo, Catherine Houlihan, Hannah C. Howson‐Wells, Jonathan Hubb, Hannah Huckson, Warwick Hughes, Joseph Hughes, Margaret Hughes, Stephanie Hutchings, Giles Idle, Chris J. Illingworth, Robert Impey, Dianne Irish-Tavares, Miren Iturriza-Gomara, Rhys Izuagbe, Christopher Jackson, Ben Jackson, Leigh Jackson, Kathryn Jackson, David K. Jackson, Aminu S. Jahun, Victoria James, Keith James, Christopher Jeanes, Aaron R. Jeffries,

We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted ...

Cell Press

Artigo

Harald Vöhringer, Theo Sanderson, Matthew Sinnott, Nicola De Maio, Thuy Nguyen, Richard Goater, Frank Schwach, Ian Harrison, Joel Hellewell, Cristina V. Ariani, Sónia Gonçalves, David K. Jackson, Ian Johnston, Alexander W. Jung, Callum Saint, John Sillitoe, Maria Suciu, Nick Goldman, Jasmina Panovska‐Griffiths, Irina Abnizova, Louise Aigrain, Alex Alderton, Mozam Ali, Laura Allen, Roberto Amato, Ralph Anderson, Cristina V. Ariani, Siobhan Austin-Guest, Sendu Bala, Jeffrey C. Barrett, Andrew R. Bassett, Kristina Battleday, James R. Beal, Mathew A. Beale, Charlotte Beaver, Sam Bellany, Tristram Bellerby, Katie Bellis, Duncan Berger, Matthew Berriman, Emma Betteridge, Paul Bevan, Simon Binley, Jason Bishop, Kirsty Blackburn, James Bonfield, Nick Boughton, Sam Bowker, Timothy Brendler-Spaeth, Iraad F. Bronner, Tanya Brooklyn, Sarah K. Buddenborg, R.L. Bush, Catarina Caetano, Alex Cagan, Nicola Carter, Joanna Cartwright, Tiago Monteiro, Liz Chapman, Tracey-Jane Chillingworth, Peter Clapham, Richard Clark, Adrian Clarke, Catriona Clarke, Daryl Cole, Elizabeth Cook, Maria Coppola, Linda Cornell, Clare Cornwell, Craig Corton, Abby Crackett, Alison Cranage, Harriet Craven, Sarah Craw, Mark Crawford, Tim Cutts, Monika Dabrowska, Matt Davies, Robert M. Davies, Joseph Dawson, Callum Day, Aiden Densem, Thomas Dibling, Cat Dockree, D. C. Dodd, Sunil Kumar Dogga, Matthew J. Dorman, Gordon Dougan, Martin Dougherty, Alexander Dove, Lucy Drummond, Eleanor Drury, Monika Dudek, Jillian Durham, Laura Durrant, Elizabeth Easthope, Sabine Eckert, Peter Ellis, Ben W. Farr, Michael Fenton, Marcella Ferrero, Neil Flack, Howerd Fordham, Grace Forsythe, Luke Foulser, Matt Francis, Audrey Fraser, Adam Freeman, Anastasia Galvin, Maria Garcia-Casado, Alex Gedny, Sophia T. Girgis, James Glover, Sónia Gonçalves, Scott Goodwin, Oliver Gould, Marina Gourtovaia, Andy Gray, Emma Gray, Chris Griffiths, Yong Gu, Florence Guerin, Will Hamilton, Hannah Hanks, Ewan M. Harrison, Alexandria Harrott, Edward Harry, Julia Harvison, Paul T. Heath, Anastasia Hernández-Koutoucheva, Rhiannon Hobbs, Dave Holland, Sarah Holmes, Gary Hornett, Nicholas Hough, Liz Huckle, Lena Hughes-Hallet, Adam Hunter, Stephen Inglis, Sameena Iqbal, Adam Jackson, David K. Jackson, Keith James, Dorota Jamrozy, Carlos Jimenez Verdejo, Matthew Jones, Kalyan Kallepally, Leanne Kane, Keely Kay, Sally Kay, Jon Keatley, Alan Keith, Alison King, Lucy Kitchin, Matt Kleanthous, Martina Klimekova, Petra Korlević, Ksenia Krasheninnkova, Greg Lane, Cordelia Langford, Adam Laverack, Katharine Law, Mara Lawniczak, Stefanie V. Lensing, Steven N. Leonard, Laura Letchford, Kevin Lewis, Amanah Lewis-Wade, Jennifer Liddle, Quan Lin, Sarah Lindsay, Sally Linsdell, Rich Livett, Stephanie W. Lo, Rhona Long, Jamie Lovell, Jon Lovell, Catherine Ludden, James Mack, Mark Maddison, Aleksei Makunin, Irfan Mamun, Jenny Mansfield, Neil Marriott, Matt Martin, Matthew Mayho, Shane McCarthy, Jo McClintock, Samantha McGuigan, Sandra McHugh, Liz McMinn, Carl Meadows, Emily Mobley, Robin J. Moll, Maria Morra, Leanne Morrow, Kathryn Murie, Sian Nash, Claire Nathwani, Plamena Naydenova, Alexandra Neaverson, Andrew Nelson, Ed Nerou, Jon Nicholson, Tabea Nimz, Guillaume Noell, Sarah O’Meara, Valeriu Ohan, Karen Oliver, Charles Olney, Doug Ormond, Ágnes Oszlánczi, Steve Palmer, Yoke Fei Pang, Barbora Pardubska, Naomi Park, Aaron Parmar, Gaurang Patel, Minal Patel, Maggie Payne, Sharon J. Peacock, Arabella Petersen, Deborah Plowman, Tom Preston, Liam Prestwood, Christoph Puethe, Michael A. Quail, Diana Rajan, Shavanthi Rajatileka, Richard Rance, Suzannah Rawlings, Nicholas Redshaw, Joe Reynolds, Mark Reynolds, Simon Rice, Matt Richardson, Connor Roberts, Katrina Robinson, Melanie Robinson, David M. Robinson, Hazel Rogers, Eduardo Martin Rojo, Daljit Roopra, Mark E. Rose, Luke Rudd, Ramin Sadri, Nicholas Salmon, David Saul, Frank Schwach, Clare L. Scott, Phil Seekings, Lesley Shirley, Alison Simms, Matthew Sinnott, Shanthi Sivadasan, Bart Siwek, Dale Sizer, Kenneth Skeldon, Jason Skelton, Joanna Slater-Tunstill, Lisa Sloper, Nathalie Smerdon, Chris Smith, Christen Smith, James Smith, Katie Smith, Michelle Smith, Sean B. Smith, Tina Smith, Leighton Sneade, C. Soria, Catarina Sousa, Emily Souster, Andrew Sparkes, Michael Spencer-Chapman, Janet Squares, Robert Stanley, Claire Steed, Tim Stickland, Ian Still, Michael R. Stratton, Michelle Strickland, Allen Swann, Agnieszka Świątkowska, Neil Sycamore, Emma Swift, Edward Symons, Suzanne Szluha, Emma Taluy, Nunu Tao, Katy Taylor, Sam Taylor, Stacey Thompson, Mark A. Thompson, M. Thomson, Nicholas M. Thomson,

Abstract The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. This analysis reveals a series of subepidemics that peaked in early autumn 2020, followed by a jump ...

Nature Portfolio

Artigo

Brian J. Willett, Joe Grove, Oscar A. MacLean, Craig Wilkie, Giuditta De Lorenzo, Wilhelm Furnon, Diego Cantoni, Sam Scott, Nicola Logan, Shirin Ashraf, Maria Manali, Agnieszka M. Szemiel, Vanessa M. Cowton, Elen Vink, William T. Harvey, Christopher Davis, Patawee Asamaphan, Katherine Smollett, L. Tong, Richard Orton, Joseph Hughes, Poppy Holland, Vanessa Silva, David J. Pascall, Kathryn Puxty, Ana da Silva Filipe, Gonzalo Yebra, Sharif Shaaban, Matthew T. G. Holden, Rute Maria Pinto, Rory Gunson, Kate Templeton, Pablo R. Murcia, Arvind H. Patel, Paul Klenerman, Susanna Dunachie, Susanna Dunachie, Paul Klenerman, Eleanor Barnes, Anthony Brown, Sandra Adele, Barbara Kronsteiner, Sam M. Murray, Priyanka Abraham, Alexandra Deeks, M. Azim Ansari, Thushan I. de Silva, Lance Turtle, Shona C. Moore, James Austin, Alex Richter, C.J. Duncan, Rebecca P. Payne, Amy Ash, Cherian Koshy, Beatrix Kele, Teresa Cutiño‐Moguel, Derek Fairley, James P. McKenna, Tanya Curran, Helen Adams, Christophe Fraser, David Bonsall, Helen Fryer, Katrina Lythgoe, Emma C. Thomson, Tanya Golubchik, Abigail Murray, Dawn Singleton, Shaun M. Beckwith, Anna Mantzouratou, Magdalena Barrow, Sarah L. Buchan, Nicola Reynolds, Ben Warne, Joshua Maksimovic, Karla Spellman, Kathryn McCluggage, John P.T. Mo, Robert Beer, Safiah Afifi, Sian Morgan, Andrew Mack, Angela Marchbank, Anna Price, Arthur Morriss, Catherine Bresner, Christine Kitchen, Ian Merrick, Joel Southgate, Martyn F. Guest, Owen Jones, Robert J. Munn, Thomas R. Connor, Thomas Whalley, Trudy Workman, William Fuller, Amita Patel, Bindi Patel, Gaia Nebbia, Jonathan Edgeworth, Luke B. Snell, Rahul Batra, Themoula Charalampous, Angela H. Beckett, Ekaterina Shelest, Samuel C. Robson, Anthony P. Underwood, Ben Taylor, Corin Yeats, David M. Aanensen, Khalil Abudahab, Mirko Menegazzo, Amelia Joseph, Gemma Clark, Hannah C. Howson‐Wells, Louise Berry, Manjinder Khakh, Michelle M. Lister, Tim Boswell, Vicki M. Fleming, Christopher W. Holmes, Claire McMurray, Jessica Shaw, Julian W. Tang, Karlie Fallon, Mina Odedra, Nicholas J. Willford, Paul Bird, Thomas Helmer, Lesley-Anne Williams, Nicola Sheriff, Stephen Campbell, Veena Raviprakash, Victoria Blakey, Christopher Moore, Fei Sang, Johnny Debebe, Matthew Carlile, Matthew Loose, Nadine Holmes, Victoria Wright, M. Estee Torok, William L. Hamilton, Alessandro M. Carabelli, Andrew Jermy, Beth Blane, Carol Churcher, Catherine Ludden, Dinesh Aggarwal, Elaine Westwick, Ellena Brooks, Georgina M. McManus, Katerina Galai, Kenneth G. C. Smith, Kim S. Smith, MacGregor Cox, Mireille Fragakis, Patrick H. Maxwell, Sarah Judges, Sharon J. Peacock, Theresa Feltwell, Anita Kenyon, Sahar Eldirdiri, Thomas Davis, Joshua F. Taylor, Ngee Keong Tan, Alex E. Zarebski, Bernardo Gutiérrez, Jayna Raghwani, Louis du Plessis, Moritz U. G. Kraemer, Oliver G. Pybus, Sarah François, Stephen W. Attwood, Tetyana I. Vasylyeva, Aminu S. Jahun, Ian Goodfellow, Iliana Georgana, Malte L. Pinckert, Myra Hosmillo, Rhys Izuagbe, Yasmin Chaudhry, Felicity Ryan, Hannah Lowe, Samuel Moses, Luke Bedford, James S. Cargill, Warwick Hughes, Jonathan P. Moore, Susanne Stonehouse, Divya Shah, Jack C. D. Lee, Julianne R. Brown, Kathryn Harris, Laura Atkinson, Nathaniel Storey, Moira J. Spyer, Flavia Flaviani, Adela Alcolea-Medina, Jasveen Sehmi, John Ramble, Natasha Ohemeng-Kumi, Perminder Smith, Beatrice Bertolusso, Claire Thomas, Gabrielle Vernet, Jessica Lynch, Nathan Moore, Nicholas Cortes, Rebecca Williams, Stephen P. Kidd, Lisa J. Levett, Monika Pusok, Paul R. Grant, Stuart A. Kirk, Wendy Chatterton, Li Xu-McCrae, Darren Smith, Gregory R. Young, Matthew Bashton, Katie Kitchman, Kavitha Gajee, Kirstine Eastick, Patrick Lillie, Phillipa Burns, William V. Everson, Alison Cox, Alison Holmes, Frances Bolt, James Price, Marcus Pond, Paul Randell, Pinglawathee Madona, Siddharth Mookerjee, Erik Volz, Lily Geidelberg, Manon Ragonnet‐Cronin, Olivia Boyd, Rob Johnson, Cassie F. Pope, Adam A. Witney, Irene M. Monahan, Kenneth G. Laing, Katherine Smollett, Alan McNally, Claire McMurray, Joanne Stockton, Joshua Quick, Nicholas J. Loman, Radoslaw Poplawski, Samuel M. Nicholls, Will Rowe, Anibolina Castigador, Emily MacNaughton, Kate El Bouzidi, Malur Sudhanva, Temi Lampejo, Rocio T. Martinez Nunez, Cassie Breen, Graciela Sluga, Karen T. Withell, Nicholas W. Machin, Ryan P. George, Shazaad S. Y. Ahmad, David T. Pritchard, Debbie Binns, Nick Wong, Victoria James, Cheryl Williams, Chris J. Illingworth, Christopher Jackson, Daniela De Angelis, David J. Pascall, Afrida Mukaddas, Alice Broos, Ana da Silva Filipe, Daniel Mair, David L. Robertson, Derek Wright, Emma C. Thomson, Igor Starinskij, Ioulia Tsatsani, James G. Shepherd, Jenna Nichols, Joseph Hughes, Kyriaki Nomikou, L. Tong, Richard Orton, Vattipally B. Sreenu, William T. Harvey, Roy Sanderson, Sarah H. O’Brien, Steven Rushton, Jon Perkins, Rachel Blacow,

Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone of the public health response to COVID-19. The emergence of hypermutated, increasingly transmissible variants of concern (VOCs) threaten this strategy. Omicron (B.1.1.529), the fifth VOC to be described, harbours multiple amino acid mutations in spike, half of which lie within the receptor-binding domain. Here we demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals ...

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Errata

Brian J. Willett, Joe Grove, Oscar A. MacLean, Craig Wilkie, Giuditta De Lorenzo, Wilhelm Furnon, Diego Cantoni, Sam Scott, Nicola S. Logan, Shirin Ashraf, Maria Manali, Agnieszka M. Szemiel, Vanessa M. Cowton, Elen Vink, William T. Harvey, Christopher Davis, Patawee Asamaphan, Katherine Smollett, L. Tong, Richard Orton, Joseph Hughes, Poppy Holland, Vanessa Silva, David J. Pascall, Kathryn Puxty, Ana da Silva Filipe, Gonzalo Yebra, Sharif Shaaban, Matthew T. G. Holden, Rute Maria Pinto, Rory Gunson, Kate Templeton, Pablo R. Murcia, Arvind H. Patel, Paul Klenerman, Susanna Dunachie, Susanna Dunachie, Paul Klenerman, Eleanor Barnes, Anthony Brown, Sandra Adele, Barbara Kronsteiner, Sam M. Murray, Priyanka Abraham, Alexandra Deeks, M. Azim Ansari, Thushan I. de Silva, Lance Turtle, Shona C. Moore, James E. Austin, Alexander Richter, C.J. Duncan, Rebecca Payne, Amy Ash, Cherian Koshy, Beatrix Kele, Teresa Cutiño‐Moguel, Derek Fairley, James P. McKenna, Tanya Curran, Helen Adams, Christophe Fraser, David Bonsall, Helen Fryer, Katrina Lythgoe, Emma C. Thomson, Tanya Golubchik, Abigail Murray, Dawn Singleton, Shaun M. Beckwith, Anna Mantzouratou, Magdalena Barrow, Sarah L. Buchan, Nicola Reynolds, Ben Warne, Joshua Maksimovic, Karla Spellman, Kathryn McCluggage, John P.T. Mo, Robert Beer, Safiah Afifi, Siân Morgan, Andrew Mack, Angela Marchbank, Anna Price, Arthur Morriss, Catherine Bresner, Christine Kitchen, Ian Merrick, Joel Southgate, Martyn F. Guest, Owen Jones, R. W. Munn, Thomas R. Connor, Thomas Whalley, Trudy Workman, William Fuller, Amita Patel, Bindi Patel, Gaia Nebbia, Jonathan D. Edgeworth, Luke B. Snell, Rahul Batra, Themoula Charalampous, Angela H. Beckett, Ekaterina Shelest, Samuel C. Robson, Anthony P. Underwood, Ben Taylor, Corin Yeats, David M. Aanensen, Khalil Abudahab, Mirko Menegazzo, Amelia Joseph, Gemma Clark, Hannah C. Howson‐Wells, Louise Berry, Manjinder Khakh, Michelle M. Lister, Tim Boswell, Vicki M. Fleming, Christopher W. Holmes, Claire McMurray, Jessica Shaw, Julian W. Tang, Karlie Fallon, Mina Odedra, Nicholas J. Willford, Paul Bird, Thomas Helmer, Lesley-Anne Williams, Nicola Sheriff, Sharon L. Campbell, Veena Raviprakash, Victoria Blakey, C. J. Moore, Fei Sang, Johnny Debebe, Matthew Carlile, Matthew Loose, Nadine Holmes, Victoria Wright, M. Estee Torok, William L. Hamilton, Alessandro M. Carabelli, Andrew Jermy, Beth Blane, Carol Churcher, Catherine Ludden, Dinesh Aggarwal, Elaine Westwick, Ellena Brooks, Georgina M. McManus, Katerina Galai, Ken R. Smith, Kim S. Smith, MacGregor Cox, Mireille Fragakis, Patrick H. Maxwell, Sarah Judges, Sharon J. Peacock, Theresa Feltwell, Anita Kenyon, Sahar Eldirdiri, Thomas P. Davis, Joshua F. Taylor, Ngee Keong Tan, Alex E. Zarebski, Bernardo Gutiérrez, Jayna Raghwani, Louis du Plessis, Moritz U. G. Kraemer, Oliver G. Pybus, Sarah François, Stephen W. Attwood, Tetyana I. Vasylyeva, Aminu S. Jahun, Ian Goodfellow, Iliana Georgana, Malte L. Pinckert, Myra Hosmillo, Rhys Izuagbe, Yasmin Chaudhry, Felicity Ryan, Hannah Lowe, Samuel Moses, Luke Bedford, James S. Cargill, Warwick Hughes, Jonathan D. Moore, Susanne Stonehouse, Divya Shah, Jack C. D. Lee, Julianne R. Brown, Kathryn Harris, Laura Atkinson, Nathaniel Storey, Moira J. Spyer, Flavia Flaviani, Adela Alcolea-Medina, Jasveen Sehmi, John Ramble, Natasha Ohemeng-Kumi, Perminder Smith, Beatrice Bertolusso, Claire Thomas, Gabrielle Vernet, Jessica Lynch, Nathan Moore, Nicholas Cortes, Rebecca Williams, Stephen P. Kidd, Lisa J. Levett, Monika Pusok, Paul R. Grant, Stuart A. Kirk, Wendy Chatterton, Li Xu-McCrae, Darren Smith, Gregory R. Young, Matthew Bashton, Katie Kitchman, Kavitha Gajee, Kirstine Eastick, Patrick Lillie, Phillipa Burns, William V. Everson, Alison Cox, Alison Holmes, Frances Bolt, James Price, Marcus Pond, Paul Randell, Pinglawathee Madona, Siddharth Mookerjee, Erik Volz, Lily Geidelberg, Manon Ragonnet‐Cronin, Olivia Boyd, Rob Johnson, Cassie F. Pope, Adam A. Witney, Irene M. Monahan, Kenneth G. Laing, Katherine Smollett, Alan McNally, Claire McMurray, Joanne Stockton, Joshua Quick, Nicholas J. Loman, Radoslaw Poplawski, Samuel M. Nicholls, Will Rowe, Anibolina Castigador, Emily MacNaughton, Kate El Bouzidi, Malur Sudhanva, Temi Lampejo, Rocio T. Martinez Nunez, Cassie Breen, Graciela Sluga, Karen T. Withell, Nicholas W. Machin, Ryan P. George, Shazaad S. Y. Ahmad, David T. Pritchard, Debbie Binns, Nicholas C. Wong, Victoria James, Cheryl Williams, Chris J. Illingworth, Christopher Jackson, Daniela De Angelis, David J. Pascall, Afrida Mukaddas, Alice Broos, Ana da Silva Filipe, Daniel Mair, David L. Robertson, Derek Wright, Emma C. Thomson, Igor Starinskij, Ioulia Tsatsani, James G. Shepherd, Jenna Nichols, Joseph Hughes, Kyriaki Nomikou, L. Tong, Richard Orton, Vattipally B. Sreenu, William T. Harvey, Roy Sanderson, Sarah H. O’Brien, Steven Rushton, Jon Perkins, Rachel Blacow,

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Oliver Eales, Andrew J. Page, Leonardo de Oliveira Martins, Haowei Wang, Barbara Bodinier, David Haw, Jakob Jonnerby, Christina Atchison, Samuel C. Robson, Thomas R. Connor, Nicholas J. Loman, Tanya Golubchik, Rocio T. Martinez Nunez, David Bonsall, Andrew Rambaut, Luke B. Snell, Rich Livett, Catherine Ludden, Sally Corden, Eleni Nastouli, Gaia Nebbia, Ian Johnston, Katrina Lythgoe, M. Estée Török, Ian Goodfellow, Jacqui Prieto, Kordo Saeed, David K. Jackson, Catherine Houlihan, Dan Frampton, William L. Hamilton, Adam A. Witney, Giselda Bucca, Cassie F. Pope, Catherine Moore, Emma C. Thomson, Ewan M. Harrison, Colin P. Smith, Fiona Rogan, Shaun M. Beckwith, Abigail Murray, Dawn Singleton, Kirstine Eastick, Liz A. Sheridan, Paul Randell, Leigh Jackson, Cristina V. Ariani, Sónia Gonçalves, Derek Fairley, Matthew Loose, Joanne Watkins, Samuel Moses, Sam Nicholls, Matthew Bull, Roberto Amato, Darren Smith, David M. Aanensen, Jeffrey C. Barrett, Dinesh Aggarwal, James G. Shepherd, Martin D. Curran, Surendra Parmar, Matthew O. Parker, Catryn Williams, Sharon Glaysher, Anthony P. Underwood, Matthew Bashton, Nicole Pacchiarini, Katie F. Loveson, Matthew Byott, Alessandro M. Carabelli, Kate Templeton, Thushan I. de Silva, Dennis Wang, Cordelia F. Langford, John Sillitoe, Rory Gunson, Simon Cottrell, Justin O’Grady, Dominic Kwiatkowski, Patrick Lillie, Nicholas Cortes, Nathan Moore, Claire Thomas, Phillipa Burns, Tabitha Mahungu, Steven Liggett, Angela H. Beckett, Matthew T. G. Holden, Lisa J. Levett, Husam Osman, Mohammed O. Hassan-Ibrahim, David Simpson, Meera Chand, Ravi Gupta, Alistair C. Darby, Steve Paterson, Oliver G. Pybus, Erik Volz, Daniela De Angelis, David L. Robertson, Iñigo Martincorena, Louise Aigrain, Andrew R. Bassett, Nick Wong, Yusri Taha, Michelle J. Erkiert, Michael H. Spencer Chapman, Rebecca Dewar, M. McHugh, Siddharth Mookerjee, Stephen Aplin, Matthew Harvey, Thea Sass, Helen Umpleby, Helen Wheeler, James McKenna, Ben Warne, Joshua F. Taylor, Yasmin Chaudhry, Rhys Izuagbe, Aminu S. Jahun, Gregory R. Young, Claire McMurray, Clare M. McCann, Andrew Nelson, Scott Elliott, Hannah Lowe, Anna Price, Matthew Crown, Sara Rey, Sunando Roy, Ben Temperton, Sharif Shaaban, Andrew R. Hesketh, Kenneth G. Laing, Irene M. Monahan, Judith Heaney, Emanuela Pelosi, Siona Silviera, Eleri Wilson-Davies, Helen Fryer, Helen Adams, Louis du Plessis, Rob Johnson, William T. Harvey, Joseph Hughes, Richard Orton, Lewis G. Spurgin, Yann Bourgeois, Chris Ruis, Áine O’Toole, Marina Gourtovaia, Theo Sanderson, Christophe Fraser, Jonathan Edgeworth, Judith Breuer, Stephen L. Michell, John A. Todd, John P.T. Mo, David Buck, Kavitha Gajee, Gemma L. Kay, Sharon J. Peacock, David Heyburn, Katie Kitchman, Alan McNally, David T. Pritchard, Samir Dervisevic, Peter Muir, Esther Robinson, Barry Vipond, Newara Ramadan, Christopher Jeanes, Danni Weldon, Jana Catalan, Neil Jones, Ana da Silva Filipe, Chris Williams, Marc Fuchs, Julia Miskelly, Aaron R. Jeffries, Karen Oliver, Naomi R. Park, Amy Ash, Cherian Koshy, Magdalena Barrow, Sarah L. Buchan, Anna Mantzouratou, Gemma Clark, Christopher W. Holmes, Stephen Campbell, Thomas Davis, Ngee Keong Tan, Julianne R. Brown, Kathryn Harris, Stephen P. Kidd, Paul R. Grant, Li Xu-McCrae, Alison Cox, Pinglawathee Madona, Marcus Pond, Paul Randell, Karen T. Withell, Cheryl Williams, Clive Graham, Rebecca Denton-Smith, Emma Swindells, Robyn Turnbull, Tim J. Sloan, Andrew Bosworth, Stephanie Hutchings, Hannah M. Pymont, Anna Casey, Liz Ratcliffe, Christopher R. Jones, Bridget Knight, Tanzina Haque, Jennifer Hart, Dianne Irish-Tavares, Eric Witele, Craig Mower, Louisa K. Watson, Jennifer Collins, Gary Eltringham, Dorian Crudgington, Ben Macklin, Miren Iturriza‐Gómara, Anita O. Lucaci, C. Patrick McClure, Matthew Carlile, Nadine Holmes, Christopher Moore, Nathaniel Storey, Stefan Rooke, Gonzalo Yebra, Noel Craine, Malorie Perry, Nabil-Fareed Alikhan, Stephen Bridgett, Kate F. Cook, Christopher Fearn, Salman Goudarzi, Ronan A Lyons, Thomas Williams, Sam Haldenby, Jillian Durham, Steven N. Leonard, Robert M. Davies, Rahul Batra, Beth Blane, Moira J. Spyer, Perminder Smith, Mehmet Yavus, Rachel Williams, Adhyana I. K. Mahanama, Buddhini Samaraweera, Sophia T. Girgis, Samantha E. Hansford, Angie Green, Charlotte Beaver, Katherine L. Bellis, Matthew J. Dorman, Sally Kay, Liam Prestwood, Shavanthi Rajatileka, Joshua Quick, Radoslaw Poplawski, Nicola Reynolds, Andrew Mack, Arthur Morriss, Thomas Whalley, Bindi Patel, Iliana Georgana, Myra Hosmillo, Malte L. Pinckert, Joanne Stockton, John Henderson, Amy Hollis, William T. Stanley, Wen C. Yew, Richard Myers, Alicia Thornton, Alexander Adams, Tara Annett, Hibo Asad, Alec Birchley, Jason Coombes, Johnathan M. Evans, Laia Fina, Bree Gatica-Wilcox, Lauren Gilbert, Lee Graham, Jessica Hey, Ember Hilvers, Sophie Jones,

Abstract Background Since the emergence of SARS-CoV-2, evolutionary pressure has driven large increases in the transmissibility of the virus. However, with increasing levels of immunity through vaccination and natural infection the evolutionary pressure will switch towards immune escape. Genomic surveillance in regions of high immunity is crucial in detecting emerging variants that can more successfully navigate the immune landscape. Methods We present phylogenetic relationships and lineage dynamics ...

BioMed Central

Artigo

Kerstin Kläser, Erika Molteni, Mark S. Graham, Liane S. Canas, Marc F. Österdahl, Michela Antonelli, Liyuan Chen, Jie Deng, Benjamin Murray, Eric Kerfoot, Jonathan Wolf, Anna May, Ben Fox, Joan Capdevila Pujol, David M. Aanensen, Khalil Abudahab, Helen Adams, Alexander Adams, Safiah Afifi, Dinesh Aggarwal, Shazaad S. Y. Ahmad, Louise Aigrain, Adela Alcolea-Medina, Nabil-Fareed Alikhan, Elias Allara, Roberto Amato, Adrienn Angyal, Tara Annett, Stephen Aplin, Cristina V. Ariani, Hibo Asad, Amy Ash, Paula Ashfield, Fiona Ashford, Laura Atkinson, Stephen W. Attwood, Cressida Auckland, Alp Aydin, David Baker, Paul Baker, Carlos E. Balcazar, Jonathan K. Ball, Jeffrey C. Barrett, Magdalena Barrow, Edward Barton, Matthew Bashton, Andrew R. Bassett, Rahul Batra, Chris Baxter, Nadua Bayzid, Charlotte Beaver, Angela H. Beckett, Shaun M. Beckwith, Luke Bedford, Robert Beer, Andrew D. Beggs, Katherine L. Bellis, Louise Berry, Beatrice Bertolusso, Angus Best, Emma Betteridge, David Bibby, Kelly Bicknell, Debbie Binns, Alec Birchley, Paul Bird, Chloe Bishop, Rachel Blacow, Victoria Blakey, Beth Blane, Frances Bolt, James Bonfield, Stephen Bonner, David Bonsall, Tim Boswell, Andrew Bosworth, Yann Bourgeois, Olivia Boyd, Declan Bradley, Cassie Breen, Catherine Bresner, Judith Breuer, Stephen Bridgett, Iraad F. Bronner, Ellena Brooks, Alice Broos, Julianne R. Brown, Giselda Bucca, Sarah L. Buchan, David Buck, Matthew Bull, Phillipa Burns, Shirelle Burton-Fanning, Timothy Byaruhanga, Matthew Byott, Sharon L. Campbell, Alessandro M. Carabelli, James S. Cargill, Matthew Carlile, Silvia Carvalho, Anna Casey, Anibolina Castigador, Jana Catalan, Vicki Chalker, Nicola J. Chaloner, Meera Chand, Joseph Chappell, Themoula Charalampous, Wendy Chatterton, Yasmin Chaudhry, Carol Churcher, Gemma Clark, Phillip Clarke, Benjamin J. Cogger, Kevin D. Cole, Jennifer Collins, Rachel Colquhoun, Thomas R. Connor, Kate F. Cook, Jason D. Coombes, Sally Corden, Claire Cormie, Nicholas Cortes, Marius Cotic, Seb Cotton, Simon Cottrell, Lindsay Coupland, MacGregor Cox, Alison Cox, Noel Craine, Liam Crawford, Aidan Cross, Matthew Crown, Dorian Crudgington, Nicola Cumley, Tanya Curran, Martin D. Curran, Ana da Silva Filipe, Gavin Dabrera, Alistair C. Darby, Rose K. Davidson, Alisha Davies, Robert M. Davies, Thomas P. Davis, Daniela De Angelis, Elen De Lacy, Leonardo de Oliveira Martins, Thushan I. de Silva, Johnny Debebe, Rebecca Denton-Smith, Samir Dervisevic, Rebecca Dewar, Jayasree Dey, Joana Dias, Donald Dobie, Matthew J. Dorman, Fatima Downing, Megan Driscoll, Louis du Plessis, Nichola Duckworth, Jillian Durham, Kirstine Eastick, Lisa J. Easton, Richard Eccles, Jonathan D. Edgeworth, Sue Edwards, Kate El Bouzidi, Sahar Eldirdiri, Nicholas Ellaby, Scott Elliott, Gary Eltringham, Leah Ensell, Michelle J. Erkiert, Marina Escalera Zamudio, Sarah Essex, Johnathan M. Evans, Cariad Evans, William V. Everson, Derek Fairley, Karlie Fallon, Arezou Fanaie, Ben W. Farr, Christopher Fearn, Theresa Feltwell, Lynne Ferguson, Laia Fina, Flavia Flaviani, Vicki M. Fleming, Stephen R. Forrest, Ebenezer Foster-Nyarko, Benjamin H. Foulkes, Luke Foulser, Mireille Fragakis, Dan Frampton, Sarah François, Christophe Fraser, Timothy M. Freeman, Helen Fryer, Marc Fuchs, William Fuller, Kavitha Gajee, Katerina Galai, Abbie Gallagher, Eileen Gallagher, Michael D. Gallagher, Marta Gallis, Amy Gaskin, Bree Gatica-Wilcox, Lily Geidelberg, Matthew Gemmell, Iliana Georgana, Ryan P. George, Laura Gifford, Lauren Gilbert, Sophia T. Girgis, Sharon Glaysher, Emily J. Goldstein, Tanya Golubchik, Andrea N. Gomes, Sónia Gonçalves, Ian Goodfellow, Scott Goodwin, Salman Goudarzi, Marina Gourtovaia, Clive Graham, Lee Graham, Paul R. Grant, Luke R. Green, Angie Green, Jane Greenaway, Richard I. Gregory, Martyn F. Guest, Rory Gunson, Ravindra K. Gupta, Bernardo Gutiérrez, Sam Haldenby, William L. Hamilton, Samantha E. Hansford, Tanzina Haque, Kathryn Harris, Ian Harrison, Ewan M. Harrison, Jennifer Hart, John A. Hartley, William T. Harvey, M J Harvey, Mohammed O. Hassan-Ibrahim, Judith Heaney, Thomas Helmer, John Henderson, Andrew R. Hesketh, Jessica Hey, David Heyburn, Ellen E. Higginson, Verity Hill, Jack Hill, Rachel A. Hilson, Ember Hilvers, Matthew T. G. Holden, Amy Hollis, Christopher W. Holmes, Nadine Holmes, Alison Holmes, Richard Hopes, Hailey Hornsby, Myra Hosmillo, Catherine Houlihan, Hannah C. Howson‐Wells, Sharon N. Hsu, Jonathan Hubb, Hannah Huckson, Warwick Hughes, Joseph Hughes, Margaret Hughes, Stephanie Hutchings, Giles Idle, Chris J. Illingworth, Robert Impey, Dianne Irish-Tavares, Miren Iturriza-Gomara, Rhys Izuagbe, Christopher Jackson, Ben Jackson, Leigh Jackson, Kathryn Jackson, David K. Jackson, Aminu S. Jahun, Victoria James, Keith James, Christopher Jeanes, Aaron R. Jeffries, Sarah Jeremiah, Andrew Jermy, John P.T. Mo, Rob Johnson, KATE JOHNSON,

The Delta (B.1.617.2) variant was the predominant UK circulating SARS-CoV-2 strain between May and December 2021. How Delta infection compares with previous variants is unknown. This prospective observational cohort study assessed symptomatic adults participating in the app-based COVID Symptom Study who tested positive for SARS-CoV-2 from May 26 to July 1, 2021 (Delta overwhelmingly the predominant circulating UK variant), compared (1:1, age- and sex-matched) with individuals presenting from December ...

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Sema Nickbakhsh, Joseph Hughes, Nicolaos Christofidis, Emily Griffiths, Sharif Shaaban, Jessica Enright, Katherine Smollett, Kyriaki Nomikou, Natasha Palmalux, L. Tong, Stephen Carmichael, Vattipally B. Sreenu, Richard Orton, Emily J. Goldstein, Rachael Tomb, Samuel C. Robson, Thomas R. Connor, Nicholas J. Loman, Tanya Golubchik, Rocio T. Martinez Nunez, David Bonsall, Andrew Rambaut, Luke B. Snell, Rich Livett, Catherine Ludden, Sally Corden, Eleni Nastouli, Gaia Nebbia, Ian Johnston, Katrina Lythgoe, M. Estée Török, Ian Goodfellow, Jacqui Prieto, Kordo Saeed, David K. Jackson, Catherine Houlihan, Dan Frampton, William L. Hamilton, Adam A. Witney, Giselda Bucca, Cassie F. Pope, Catherine Moore, Emma C. Thomson, Ewan M. Harrison, Colin P. Smith, Fiona Rogan, Shaun M. Beckwith, Abigail Murray, Dawn Singleton, Kirstine Eastick, Liz A. Sheridan, Paul Randell, Leigh Jackson, Cristina V. Ariani, Sónia Gonçalves, Derek Fairley, Matthew Loose, Joanne Watkins, Samuel Moses, Sam Nicholls, Matthew Bull, Roberto Amato, Darren Smith, David M. Aanensen, Jeffrey C. Barrett, Dinesh Aggarwal, James G. Shepherd, Martin D. Curran, Surendra Parmar, Matthew O. Parker, Catryn Williams, Sharon Glaysher, Anthony P. Underwood, Matthew Bashton, Nicole Pacchiarini, Katie F. Loveson, Matthew Byott, Alessandro M. Carabelli, Kate Templeton, Thushan I. de Silva, Dennis Wang, Cordelia F. Langford, John Sillitoe, Rory Gunson, Simon Cottrell, Justin O’Grady, Dominic Kwiatkowski, Patrick Lillie, Nicholas Cortes, Nathan Moore, Claire Thomas, Phillipa Burns, Tabitha Mahungu, Steven Liggett, Angela H. Beckett, Matthew T. G. Holden, Lisa J. Levett, Husam Osman, Mohammed O. Hassan-Ibrahim, David Simpson, Mrera Chand, Ravi Gupta, Alistair C. Darby, Steve Paterson, Oliver G. Pybus, Erik Volz, Daniela De Angelis, David L. Robertson, Andrew J. Page, Inigo Martincorena, Louise Aigrain, Andrew R. Bassett, Nick Wong, Yusri Taha, Michelle J. Erkiert, Michael H. Spencer Chapman, Rebecca Dewar, M. McHugh, Siddharth Mookerjee, Stephen Aplin, Matthew Harvey, Thea Sass, Helen Umpleby, Helen Wheeler, James McKenna, Ben Warne, Joshua F. Taylor, Yasmin Chaudhry, Rhys Izuagbe, Aminu S. Jahun, Gregory R. Young, Claire McMurray, Clare M. McCann, Andrew Nelson, Scott Elliott, Hannah Lowe, Anna Price, Matthew Crown, Sara Rey, Sunando Roy, Ben Temperton, Sharif Shaaban, Andrew R. Hesketh, Kenneth G. Laing, Irene M. Monahan, Judith Heaney, Emanuela Pelosi, Siona Silviera, Eleri Wilson-Davies, Helen Fryer, Helen Adams, Louis du Plessis, Rob Johnson, William T. Harvey, Joseph Hughes, Richard Orton, Lewis G. Spurgin, Yann Bourgeois, Chris Ruis, Áine O’Toole, Marina Gourtovaia, Theo Sanderson, Christophe Fraser, Jonathan Edgeworth, Judith Breuer, Stephen L. Michell, John A. Todd, John P.T. Mo, David Buck, Kavitha Gajee, Gemma L. Kay, Sharon J. Peacock, David Heyburn, Katie Kitchman, Alan McNally, David T. Pritchard, Samir Dervisevic, Peter Muir, Esther Robinson, Barry Vipond, Newara Ramadan, Christopher Jeanes, Danni Weldon, Jana Catalan, Neil Jones, Ana da Silva Filipe, Chris Williams, Marc Fuchs, Julia Miskelly, Aaron R. Jeffries, Karen Oliver, Naomi R. Park, Amy Ash, Cherian Koshy, Magdalena Barrow, Sarah L. Buchan, Anna Mantzouratou, Gemma Clark, Christopher W. Holmes, Stephen Campbell, Thomas Davis, Ngee Keong Tan, Julianne R. Brown, Kathryn Harris, Stephen P. Kidd, Paul R. Grant, Li Xu-McCrae, Alison Cox, Pinglawathee Madona, Marcus Pond, Paul Randell, Karen T. Withell, Cheryl Williams, Clive Graham, Rebecca Denton-Smith, Emma Swindells, Robyn Turnbull, Tim J. Sloan, Andrew Bosworth, Stephanie Hutchings, Hannah M. Pymont, Anna Casey, Liz Ratcliffe, Christopher R. Jones, Bridget Knight, Tanzina Haque, Jennifer Hart, Dianne Irish-Tavares, Eric Witele, Craig Mower, Louisa K. Watson, Jennifer Collins, Gary Eltringham, Dorian Crudgington, Ben Macklin, Miren Iturriza‐Gómara, Anita O. Lucaci, C. Patrick McClure, Matthew Carlile, Nadine Holmes, Christopher Moore, Nathaniel Storey, Stefan Rooke, Gonzalo Yebra, Noel Craine, Malorie Perry, Nabil-Fareed Alikhan, Stephen Bridgett, Kate F. Cook, Christopher Fearn, Salman Goudarzi, Ronan A Lyons, Thomas Williams, Sam Haldenby, Jillian Durham, Steven N. Leonard, Robert M. Davies, Rahul Batra, Beth Blane, Moira J. Spyer, Perminder Smith, Mehmet Yavus, Rachel Williams, Adhyana I. K. Mahanama, Buddhini Samaraweera, Sophia T. Girgis, Samantha E. Hansford, Angie Green, Charlotte Beaver, Katherine L. Bellis, Matthew J. Dorman, Sally Kay, Liam Prestwood, Shavanthi Rajatileka, Joshua Quick, Radoslaw Poplawski, Nicola Reynolds, Andrew Mack, Arthur Morriss, Thomas Whalley, Bindi Patel, Iliana Georgana, Myra Hosmillo, Malte L. Pinckert, Joanne Stockton, John Henderson, Amy Hollis, William T. Stanley, Wen C. Yew, Richard Myers, Alicia Thornton, Alexander Adams, Tara Annett, Hibo Asad, Alec Birchley, Jason Coombes,

Whole genome sequencing of SARS-CoV-2 has occurred at an unprecedented scale, and can be exploited for characterising outbreak risks at the fine-scale needed to inform control strategies. One setting at continued risk of COVID-19 outbreaks are higher education institutions, associated with student movements at the start of term, close living conditions within residential halls, and high social contact rates. Here we analysed SARS-CoV-2 whole genome sequences in combination with epidemiological data ...

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Artigo Acesso aberto Revisado por pares

Julius Vahl, Stephanie E. Weissinger, Claudia Welke, Thomas K. Hoffmann, Johannes D ouml scher,

Background: Chemokines are involved in the chemotaxis of immune cells, angiogenesis, and cancer progression.For several tumor entities, it has been shown that the expression of chemokine receptors CCR7 and CXCR5 is of prognostic relevance.However, their role in the development of sinonasal cancer is currently not understood.Patients and Methods: This work aimed to examine the relevance of chemokine receptor expression of CXCR5 and CXCR7 in sinonasal squamous cell carcinoma and adenocarcinoma and ...

Tópico(s): Sinusitis and nasal conditions

2023 - | Egyptian Journal of Ear Nose Throat and Allied Sciences

Artigo Acesso aberto Revisado por pares

Maria Rosaria Mollo, Luisa Cirillo, Claudia Russo, Dario Antonini, Caterina Missero,

... 1941Google Scholar, Julapalli et al., 2009Julapalli M.R. Scher R.K. Sybert V.P. Siegfried E.C. ...

Tópico(s): Virus-based gene therapy research

2018 - Elsevier BV | Journal of Investigative Dermatology Symposium Proceedings