
Lorena Claudia de Souza Moreira, Regina Coeli Ruschel,
Gestão de facilidades, também conhecida por Facility Management (FM), envolve a gestão de pessoas, processos e espaços podendo ser auxiliada por sistemas de informação específicos. A adoção da Modelagem da Informação da Construção (Building Information Modeling - BIM) na gestão de facilidades resulta em benefícios assim como em outras etapas do ciclo de vida da edificação. Desta forma, apesar de incipiente é crescente o interesse no uso do BIM na área de gestão de facilidades e gerenciamento da informação, ...
Tópico(s): Infrastructure Maintenance and Monitoring
2015 - UNIVERSIDADE ESTADUAL DE CAMPINAS | PARC Pesquisa em Arquitetura e Construção

Lorena Claudia de Souza Moreira, Paula Pontes Mota, Fernanda Almeida Machado,
In Brazil, the Architecture, Engineering, and Construction (AEC) industry is a high-risk segment that accumulates workplace injuries. National standards concerning Risk Management in construction require the production of Risk Maps, aiming at increasing users' awareness about risks and hazards on site. However, the traditional process of implementing Risk Maps has limitations that reduce their efficiency in a real application. The adoption of innovative technologies such as Building Information Modeling ( ...
Tópico(s): Construction Project Management and Performance
2020 - Springer Nature | Lecture notes in civil engineering

Lorena Mayana Beserra de Oliveira, Cláudia Maria Leal Bevilaqua, Iara Térsia Freitas Macedo, Selene Maia de Morais, Maria Vivina Barros Monteiro, C.C. Campello, Wesley Lyeverton Correia Ribeiro, Emanuelle Karine Frota Batista,
Tanniferous plants represent a promising alternative for controlling gastrointestinal nematodes of small ruminants. This experiment evaluated the effects of extracts from the leaf and stem of Anadenanthera colubrina, Leucaena leucocephala and Mimosa tenuiflora on larval exsheathment of Haemonchus contortus in vitro and verified the role of tannins in this process. Third-stage larvae of H. contortus were incubated with extracts for 3 hours and were exposed to sodium hypochlorite solution. The extracts ...
Tópico(s): Coccidia and coccidiosis research
2011 - Colégio Brasileiro de Parasitologia Veterinaria | Revista Brasileira de Parasitologia Veterinária/Brazilian Journal of Veterinary Parasitology

Lorena Mayana Beserra de Oliveira, Cláudia Maria Leal Bevilaqua, Iara Térsia Freitas Macedo, Selene Maia de Morais, Lyeghyna K.A. Machado, C.C. Campello, Mayara de Aquino Mesquita,
Tópico(s): Nematode management and characterization studies
2011 - Springer Science+Business Media | Parasitology Research

Lorena Mayana Beserra de Oliveira, Cláudia Maria Leal Bevilaqua, C.T.C. Costa, Iara Térsia Freitas Macedo, Renata Simões Barros, Ana Carolina Melo Rodrigues-Inoue, Ana Lourdes Fernandes Camurça-Vasconcelos, Selene Maia de Morais, Y.C. Lima, Luís Sérgio Vieira, Anderson Marliere Navarro,
The development of anthelmintic resistance has made the search for alternatives to control gastrointestinal nematodes of small ruminants imperative. Among these alternatives are several medicinal plants traditionally used as anthelmintics. This work evaluated the efficacy of Cocos nucifera fruit on sheep gastrointestinal parasites. The ethyl acetate extract obtained from the liquid of green coconut husk fiber (LGCHF) was submitted to in vitro and in vivo tests. The in vitro assay was based on egg ...
Tópico(s): Animal Nutrition and Physiology
2008 - Elsevier BV | Veterinary Parasitology
Dimas Carolina Belisario, Muhlis Akman, Martina Godel, Virginia Campani, Maria Pia Patrizio, Lorena Scotti, Claudia Maria Hattinger, Giuseppe De Rosa, Massimo Donadelli, Massimo Serra, Joanna Kopecka, Chiara Riganti,
The ATP Binding Cassette transporter B1 (ABCB1) induces chemoresistance in osteosarcoma, because it effluxes doxorubicin, reducing the intracellular accumulation, toxicity, and immunogenic cell death induced by the drug. The ATP Binding Cassette transporter A1 (ABCA1) effluxes isopentenyl pyrophosphate (IPP), a strong activator of anti-tumor Vγ9Vδ2 T-cells. Recruiting this population may represent an alternative strategy to rescue doxorubicin efficacy in ABCB1-expressing osteosarcoma. In this work, ...
Tópico(s): MicroRNA in disease regulation
2020 - Multidisciplinary Digital Publishing Institute | Cells
María Paula Ceballos, Giulia Decándido, Ariel D. Quiroga, Carla G. Comanzo, Verónica Inés Livore, Florencia Lorenzetti, Flavia Lambertucci, Lorena Chazarreta-Cifre, Claudia Banchio, Marı́a de Luján Alvarez, Aldo D. Mottino, María Cristina Carrillo,
Sirtuins (SIRTs) 1 and 2 deacetylases are overexpressed in hepatocellular carcinoma (HCC) and are associated with tumoral progression and multidrug resistance (MDR). In this study we analyzed whether SIRTs 1 and 2 activities blockage was able to affect cellular survival and migration and to modulate p53 and FoxO1 acetylation in HepG2 and Huh7 cells. Moreover, we analyzed ABC transporters P-glycoprotein (P-gp) and multidrug resistance-associated protein 3 (MRP3) expression. We used cambinol and EX-527 ...
Tópico(s): RNA Interference and Gene Delivery
2018 - Elsevier BV | Toxicology Letters

Géssica Soares Cavalcante, Selene Maia de Morais, Weibson Paz Pinheiro André, José Vilemar de Araújo Filho, Celli Rodrigues Muniz, Letícia Oliveira da Rocha, Wesley Lyeverton Correia Ribeiro, Ana Lívya Moreira Rodrigues, Lorena Mayana Beserra de Oliveira, Cláudia Maria Leal Bevilaqua, Márcio V. Ramos,
Abstract This study aimed to evaluate the anthelmintic and ultrastructural effects of Calotropis procera latex on Haemonchus contortus. C. procera latex was twice centrifuged at 10,000×g and dialyzed to obtain a fraction rich in proteins, named LP (latex protein), and at 3,000 rpm to obtain a fraction rich in secondary metabolites, named LNP (latex non-protein). Specimens of H. contortus exposed to LNP, LP and PBS in the Adult Worm Motility Test (AWMT) were submitted to scanning (SEM) and transmission ( ...
Tópico(s): Cynara cardunculus studies
2020 - Colégio Brasileiro de Parasitologia Veterinaria | Revista Brasileira de Parasitologia Veterinária/Brazilian Journal of Veterinary Parasitology
Claudia Favari, José Fernando Rinaldi de Alvarenga, Lorena Sánchez-Martínez, Nicole Tosi, Cristiana Mignogna, Eleonora Cremonini, Claudine Manach, Letizia Bresciani, Daniele Del Rio, Pedro Mena,
This systematic review provides an overview of the available evidence on the inter-individual variability (IIV) in the absorption, distribution, metabolism, and excretion (ADME) of phenolic metabolites and its determinants. Human studies were included investigating the metabolism and bioavailability of (poly)phenols and reporting IIV. One hundred fifty-three studies met the inclusion criteria. Inter-individual differences were mainly related to gut microbiota composition and activity but also to genetic ...
Tópico(s): Bioactive Compounds in Plants
2024 - Elsevier BV | Redox Biology
Weibson Paz Pinheiro André, José Luís de Paiva, Géssica Soares Cavalcante, Wesley Lyeverton Correia Ribeiro, José Araújo Filho, Bruno C. Cavalcanti, Selene de Morais, Lorena de Oliveira, Cláudia Maria Leal Bevilaqua, Flávia Oliveira Monteiro da Silva Abreu,
Carvacrol (CV) and carvacryl acetate (CVA) are bioactive compounds that have anthelmintic action and the nanoencapsulation may be an alternative to potentialize their efficacy.The aim of this work was to nanoencapsulate CV and CVA using chitosan/gums and evaluate cytotoxicity and the anthelmintic activity.A 2 4 factorial experimental design was performed to determine the influence of gum type (arabic or chichá), amount of surfactant and the number of layers in the nanoencapsulation degree.CVA and CV ...
Tópico(s): Nanocomposite Films for Food Packaging
2020 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society

Anna Caroline Campos Aguiar, Júlia Risso Parisi, Renata Neves Granito, Lorena Ramos Freitas de Sousa, Ana Cláudia Muniz Rennó, Marcos L. Gazarini,
Malaria is an infectious disease caused by protozoan parasites of the Plasmodium genus through the bite of female Anopheles mosquitoes, affecting 228 million people and causing 415 thousand deaths in 2018. Artemisinin-based combination therapies (ACTs) are the most recommended treatment for malaria; however, the emergence of multidrug resistance has unfortunately limited their effects and challenged the field. In this context, the ocean and its rich biodiversity have emerged as a very promising resource ...
Tópico(s): Synthesis and Catalytic Reactions
2021 - Multidisciplinary Digital Publishing Institute | Marine Drugs

José Vilemar de Araújo-Filho, Wesley Lyeverton Correia Ribeiro, Weibson Paz Pinheiro André, Géssica Soares Cavalcante, Thays Tabosa Rios, Gabriela Maria Schwinden, Letícia Oliveira da Rocha, Iara Térsia Freitas Macedo, Selene Maia de Morais, Cláudia Maria Leal Bevilaqua, Lorena Mayana Beserra de Oliveira,
Abstract This study aimed to evaluate the anthelmintic activity of Eucalyptus citriodora essential oil and citronellal on sheep gastrointestinal nematodes. Essential oil composition was determined by gas chromatography mass spectrometry. The substances were evaluated in vitro using adult worm motility test (AWMT) and transmission electron microscopy (TEM). The acute toxicity test in mice and the fecal egg count reduction test (FECRT) in sheep were performed. Citronellal was confirmed as the essential ...
Tópico(s): Essential Oils and Antimicrobial Activity
2019 - Colégio Brasileiro de Parasitologia Veterinaria | Revista Brasileira de Parasitologia Veterinária/Brazilian Journal of Veterinary Parasitology

Maria de Fátima Gomes da Silva, Ana Paula Dionísio, Fernando Antônio Pinto de Abreu, Cláudia Oliveira Pinto, Lorena Silva, Edy Sousa de Brito, Nédio Jair Wurlitzer, Ana Carolina Viana de Lima, Suelí Rodrigues, Wesley Faria Gomes, Dorasílvia Ferreira Pontes,
Response surface methodology (RSM) was employed for the analysis of the effects of the simultaneous enzymatic treatment using pectinolytic and cellulolytic enzyme at different concentrations, agitation, and temperature, on 13 physical and chemical characteristics of yacon pulp. After microfiltration, the characteristics of permeate flow and turbidity were also evaluated. The results indicated that the enzymatic process has been successfully employed, and the recommended conditions treatments were: ...
Tópico(s): Food composition and properties
2018 - Wiley | Journal of Food Processing and Preservation

Heraldo Lorena Guida, Carla Linhares Taxini, Cláudia Giglio de Oliveira Gonçalves, Vítor Engrácia Valenti,
Impact noise is characterized by acoustic energy peaks that last less than a second, at intervals of more than 1s.To quantify the levels of impact noise to which police officers are exposed during activities at the shooting range and to evaluate the attenuation of the hearing protector.Measurements were performed in the shooting range of a military police department. An SV 102 audiodosimeter (Svantek) was used to measure sound pressure levels. Two microphones were used simultaneously: one external ...
Tópico(s): Injury Epidemiology and Prevention
2014 - Elsevier BV | Brazilian Journal of Otorhinolaryngology

Lenita Barreto Lorena Claro, Cláudia March, Mônica Tereza Machado Mascarenhas, Isabel Antonia Barros de Castro, Maria Luiza Garcia Rosa,
This cross-sectional study describes the relationship between adolescents and health services using several indicators (self-reported diseases, self-rated health status, the need and search for health care, health care utilization and fidelity, adherence to medical prescription) and their association with socio-demographic variables. The adolescents (aged 12 to 17 years) were enrolled in schools from a district in Niteroi, Rio de Janeiro State, Brazil. Type of school, representing the participants' ...
Tópico(s): Food Security and Health in Diverse Populations
2006 - Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz | Cadernos de Saúde Pública

Lorena Mayana Beserra de Oliveira, Cláudia Maria Leal Bevilaqua, Selene Maia de Morais, Ana Lourdes Fernandes Camurça-Vasconcelos, Iara Térsia Freitas Macedo,
Os nematóides gastrintestinais são responsáveis por acentuada redução na produtividade de ovinos e caprinos. Na tentativa de controlar esses parasitos, são utilizados diversos anti-helmínticos sintéticos, mas o desenvolvimento da resistência tem tornado esse controle pouco eficaz. Na busca por alternativas de controle dos nematóides gastrintestinais, a utilização de plantas taniníferas tem despertado interesse de pesquisadores em várias regiões do mundo. Essa revisão visa a abordar os diversos aspectos ...
Tópico(s): Rabbits: Nutrition, Reproduction, Health
2011 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Ciência Rural

Iara Térsia Freitas Macedo, Cláudia Maria Leal Bevilaqua, Lorena Mayana Beserra de Oliveira, Ana Lourdes Fernandes Camurça-Vasconcelos, L. da S. Vieira, Sthenia dos Santos Albano Amóra,
Phytotherapy may be an alternative strategy for controlling gastrointestinal parasites. This study evaluated the anthelmintic efficacy of Eucalyptus citriodora essential oil (EcEO). The in vitro effects of EcEO were determined through testing the inhibition of egg hatching and larval development of Haemonchus contortus. EcEO was subjected to acute toxicity testing on mice, orally and intraperitoneally. The in vivo effects of EcEO were determined by the fecal egg count reduction test (FECRT) in goats ...
Tópico(s): Parasites and Host Interactions
2011 - Colégio Brasileiro de Parasitologia Veterinaria | Revista Brasileira de Parasitologia Veterinária/Brazilian Journal of Veterinary Parasitology

Iara Térsia Freitas Macedo, Cláudia Maria Leal Bevilaqua, Lorena Mayana Beserra de Oliveira, Ana Lourdes Fernandes Camurça-Vasconcelos, L. da S. Vieira, Fabiano Oliveira, Eudson Maia de Queiroz-Júnior, Bruno G. Portela, Reginaldo Barros, A. C. de S. Chagas,
O objetivo deste trabalho foi avaliar o efeito do óleo essencial de Eucalyptus globulus (OEEG) sobre a eclosão e desenvolvimento de larvas de Haemonchus contortus.A determinação da composição química do OEEG foi feita por meio de cromatografia gasosa acoplada à espectrometria de massa.No teste de eclosão de ovos (TEO), utilizaram-se as concentrações 21,75; 17,4; 8,7; 5,43 e 2,71 mg.mL -1 ; e no de desenvolvimento larvar (TDL) as concentrações foram 43,5; 21,75; 10,87; 5,43 e 2,71 mg.mL -1 .Cada ensaio foi ...
Tópico(s): Agricultural safety and regulations
2009 - Colégio Brasileiro de Parasitologia Veterinaria | Revista Brasileira de Parasitologia Veterinária/Brazilian Journal of Veterinary Parasitology

José Vilemar de Araújo-Filho, Wesley Lyeverton Correia Ribeiro, Weibson Pinheiro Paz André, Géssica Soares Cavalcante, Melissa de C.M. Guerra, Celli Rodrigues Muniz, Iara Térsia Freitas Macedo, Fernanda Cristina Macedo Rondon, Cláudia Maria Leal Bevilaqua, Lorena Mayana Beserra de Oliveira,
This study aimed to evaluate the effects of Eucalyptus citriodora essential oil and citronellal on a Haemonchus contortus isolate susceptible to anthelmintics, the Inbred-susceptible Edinburgh (ISE) and a resistant Kokstad isolate. The oil was analyzed by gas chromatography (GC). The products were evaluated using an egg hatching test (EHT), a larval development test (LDT) and an adult worm motility test (AWMT). The effective concentrations to inhibit 50% (EC50) of egg hatching and larval development and ...
Tópico(s): Plant Toxicity and Pharmacological Properties
2018 - Elsevier BV | Industrial Crops and Products
Noelia Miret, Carolina Pontillo, Lorena V. Zárate, Diana Kleiman de Pisarev, Claudia Cocca, Andrea Randi,
Breast cancer incidence is increasing globally and exposure to endocrine disruptors has gained importance as a potential risk factor. Hexachlorobenzene (HCB) was once used as a fungicide and, despite being banned, considerable amounts are still released into the environment. HCB acts as an endocrine disruptor in thyroid, uterus and mammary gland and was classified as possibly carcinogenic to human. This review provides a thorough analysis of results obtained in the last 15 years of research and evaluates ...
Tópico(s): Estrogen and related hormone effects
2019 - Elsevier BV | Environmental Research
Daniel Hoornweg, Lorraine Sugar, Claudia Lorena Trejos Gómez,
Cities are blamed for the majority of greenhouse gas (GHG) emissions. So too are more affluent, highly urbanized countries. If all production-and consumption-based emissions that result from lifestyle and purchasing habits are included, urban residents and their associated affluence likely account for more than 80 per cent of the world’s GHG emissions. Attribution of GHG emissions should be refined. Apportioning responsibility can be misguided, as recent literature demonstrates that residents of ...
Tópico(s): Sustainable Building Design and Assessment
2011 - SAGE Publishing | Environment and Urbanization

Cintia Cristina Santi Martignago, Beatriz Soares‐Silva, Júlia Risso Parisi, Lais Caroline Souza e Silva, Renata Neves Granito, Alessandra Mussi Ribeiro, Ana Cláudia Muniz Rennó, Lorena Ramos Freitas de Sousa, Anna Caroline Campos Aguiar,
Marine biodiversity has emerged as a very promising resource of bioactive compounds and secondary metabolites from different sea organisms. The sponge's secondary metabolites demonstrated various bioactivities and potential pharmacological properties. This systematic review of the literature focuses on the advances achieved in the antioxidant potential of marine sponges in vitro. The review was performed in accordance with PRISMA guidelines. The main inclusion criterion for analysis was articles ...
Tópico(s): Seaweed-derived Bioactive Compounds
2023 - Springer Science+Business Media | Natural Products and Bioprospecting
Daniel Hoornweg, Lorraine Sugar, Claudia Lorena Trejos Gómez,
Cities are blamed for the majority of greenhouse gas (GHG) emissions. So too are more affluent, highly urbanised countries. If all production- and consumption-based emissions that result from lifestyle and purchasing habits are included, urban residents and their associated affluence likely account for more than 80 per cent of the world’s GHG emissions. Attribution of GHG emissions should be refined. Apportioning responsibility can be misguided, as recent literature demonstrates that residents of ...
Tópico(s): Sustainable Building Design and Assessment
2020 - SAGE Publishing | Urbanisation
Alessia Potenza, Chiara Balestrieri, Martina Spiga, Luca Albarello, Federica Pedica, Francesco Manfredi, Beatrice Claudia Cianciotti, Claudia de Lalla, Oronza A. Botrugno, Cristina Faccani, Lorena Stasi, Elena Tassi, Silvia Bonfiglio, Giulia Maria Scotti, Miriam Redegalli, Donatella Biancolini, Barbara Camisa, Elena Tiziano, Camilla Sirini, Monica Casucci, Chiara Iozzi, Danilo Abbati, Fabio Simeoni, Dejan Lazarević, Ugo Elmore, Guido Fiorentini, Giulia Di Lullo, Giulia Casorati, Claudio Doglioni, Giovanni Tonon, Paolo Dellabona, Riccardo Rosati, Luca Aldrighetti, Eliana Ruggiero, Chiara Bonini,
Colorectal tumours are often densely infiltrated by immune cells that have a role in surveillance and modulation of tumour progression but are burdened by immunosuppressive signals, which might vary from primary to metastatic stages. Here, we deployed a multidimensional approach to unravel the T-cell functional landscape in primary colorectal cancers (CRC) and liver metastases, and genome editing tools to develop CRC-specific engineered T cells.We paired high-dimensional flow cytometry, RNA sequencing ...
Tópico(s): T-cell and B-cell Immunology
2023 - BMJ | Gut
Carolina Jullian, Lorena Moyano, Claudia Yáñez, Claudio Olea‐Azar,
The slightly water-soluble flavonoid quercetin (QUE) and its inclusion with either β-cyclodextrin (βCD), hydroxypropyl-β-cyclodextrin (HP-βCD) or sulfobutyl ether-β-cyclodextrin (SBE-βCD) were investigated. The stoichiometric ratios and stability constants describing the extent of formation of the complexes have been determined by phase–solubility measurements; in all cases type-AL diagrams have been obtained (soluble 1:1 complexes). The results showed that the inclusion ability of βCD and its derivatives ...
Tópico(s): Protein Interaction Studies and Fluorescence Analysis
2006 - Elsevier BV | Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy

Lorena Claudia de Souza Moreira, Regina Coeli Ruschel, Amir H. Behzadan,
On average, annual building maintenance and repair cost 1–5% of the initial building cost, which, accumulated over the building life, could even exceed the initial construction cost. New advancements in architecture, engineering, construction, and operation (AECO) are transforming the current practice of building maintenance operations using visualization and sensing technologies. This chapter will describe a use case for the application of augmented reality (AR) visualization in building maintenance ...
Tópico(s): Virtual Reality Applications and Impacts
2023 - Springer International Publishing | Springer handbooks
ANDREIA POLLIANA CASTRO DE SOUZA, Lorena Souza Costa, Cláudia Simone Baltazar de Oliveira,
O objetivo do presente estudo foi avaliar os níveis de mercúrio presente em enlatados de Sardinella spp. e Thunnus spp. As amostras foram obtidas em dois estabelecimentos comerciais onde foram adquiridas vinte amostras, dez exemplares de cada espécie, distribuídas entre as duas marcas comerciais. As análises toxicológicas de mercúrio total foram realizadas no laboratório de Toxicologia Humana e Ambiental do Núcleo de Medicina Tropical da Universidade Federal do Pará através da espectrofotometria ...
Tópico(s): Mercury impact and mitigation studies
2018 - | Revista Intertox de Toxicologia Risco Ambiental e Sociedade
Kevin Blanco, Stefanny Salcidua, Paulina Orellana, Tania Sauma-Pérez, Tomás León, Lorena Cecilia López Steinmetz, Agustín Ibáñez, Claudia Durán-Aniotz, Rolando de la Cruz,
Abstract Mild cognitive impairment (MCI) is often considered an early stage of dementia, with estimated rates of progression to dementia up to 80–90% after approximately 6 years from the initial diagnosis. Diagnosis of cognitive impairment in dementia is typically based on clinical evaluation, neuropsychological assessments, cerebrospinal fluid (CSF) biomarkers, and neuroimaging. The main goal of diagnosing MCI is to determine its cause, particularly whether it is due to Alzheimer’s disease (AD). However, ...
Tópico(s): Acute Ischemic Stroke Management
2023 - BioMed Central | Alzheimer s Research & Therapy

Francine Lorena Cuquel, Maria Carolina Sabbagh, Ana Cláudia Barneche de Oliveira,
New sunflower ( Helianthus annuus L.) cultivars with ornamental features were developed in South of Brazil by Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA-CNPSoja) . Despite its beauty, the hybrid ‘BRS-Oasis’ reaches over two meters height, with dimensions inadequate to an ornamental plant. The goal of this research was to decrease its height, without reducing stem and head diameter, to growth it as cut flower inside greenhouse or as potted plant. Daminozide, a growth retardant, was applied twice ...
Tópico(s): Plant tissue culture and regeneration
2011 - UNIVERSIDADE ESTADUAL DE LONDRINA | Semina Ciências Agrárias

Lorena Claudia de Souza Moreira, Julio Gattei Tonoli, Regina Coeli Ruschel,
A qualificação da documentação técnica produzida é relevante para potencializar a comunicação no processo ao longo das etapas de projeto e execução. Neste contexto, o Manual de uso, operação e manutenção das edificações, também conhecido como Manual do Proprietário (MP), é o documento que contempla todas as informações necessárias para guiar as atividades de manutenibilidade e uso da edificação. Dessa forma, o Manual do Proprietário é um documento essencial para o esclarecimento de dúvidas relativas ...
Tópico(s): Construction Engineering and Safety
2018 - UNIVERSIDADE DE SÃO PAULO | Gestão & Tecnologia de Projetos