Marcela Alejandra Vazquez-Prieto, Cecilia Rodríguez Lanzi, Carina Lembo, Claudio R. Galmarini, Roberto Miatello,
This study evaluates the antioxidant and the anti-inflammatory properties of garlic (G) and onion (O) in fructose-fed rats (FFR). Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+T (tempol 1 mM as control antioxidant), F+G, and F+O. Aqueous G and O extracts were administered orally in doses of 150 and 400 mg/kg/d respectively, and along with tempol, were given during the last 8 weeks of a 14-week period. At the end of the study, FFR had developed insulin ...
Tópico(s): Hops Chemistry and Applications
2011 - Hindawi Publishing Corporation | Journal of Nutrition and Metabolism
Serena Lembo, Claudio Lembo, Cataldo Patruno, Anna Balato, Nicola Balato, Fabio Ayala,
Contact eczema to foods, spices, and food additives can occur in occupational and nonoccupational settings in those who grow, handle, prepare, or cook food. Pizza is one of the most eaten foods in every continent, and pizza making is a common work in many countries. We aimed to evaluate the occurrence and the causes of contact dermatitis in pizza makers in Naples. We performed an observational study in 45 pizza makers: all the enrolled subjects had to answer a questionnaire designed to detect personal ...
Tópico(s): Occupational exposure and asthma
2014 - Lippincott Williams & Wilkins | Dermatitis
Produção Nacional
... durante os mandatos de Mário Covas, Geraldo Alckmin, Cláudio Lembo e José Serra. Aponta-se que a perspectiva ...
Tópico(s): Urban Development and Societal Issues
2010 - | Nuances estudos sobre Educação
... 1982-1986) até o governo Geraldo Alckmin e Cláudio Lembo (2002-2006), analisando adireção, mais conservadora ou mais ...
Tópico(s): Education and Public Policy
2007 - | Revista Brasileira de Segurança Pública
Giovanni Serafino, Filippo Scotti, Leonardo Lembo, Bilal Hussain, Claudio Porzi, Antonio Malacarne, Salvatore Maresca, Daniel Onori, Paolo Ghelfi, Antonella Bogoni,
This paper reviews on the latest advances in microwave photonics applied to radar systems, tracing the evolutions of functionalities in the photonic radar toward a new generation of enhanced-performance systems. Photonics is demonstrated to enable a new generation of miniaturized, heterogeneous, and distributed radars, i.e., future radars on chip with different features, working in different radio spectral regions, and organized in spatially distributed sensors for the enhanced detection of a wider ...
Tópico(s): Optical Network Technologies
2019 - Institute of Electrical and Electronics Engineers | Journal of Lightwave Technology
M Lembo, C. Sacchi, Claudio Zappador, Giorgio Bellomo, Mirella Gáboli, P P Pandolfi, Marisa Gariglio, Santo Landolfo,
Tópico(s): Virus-based gene therapy research
1998 - Springer Nature | Oncogene
Marisa Gariglio, Marco De Andrea, Marianna Lembo, Monica Ravotto, Claudio Zappador, Guido Valente, Santo Landolfo,
Abstract To examine the expression of Ifi 200 genes in vivo and add new information about their function, polyclonal monospecific rabbit antibodies, designated N-term or C-term, were raised against both the N-terminus and C-terminus of the 204 protein (p204) respectively. Western blotting analysis demonstrated that p204 and D3, another member of the Ifi 200 gene family, are constitutively expressed, though at different degrees, in bone marrow, thymus and lymph nodes, and barely detectable in the ...
Tópico(s): Cytokine Signaling Pathways and Interactions
1998 - Oxford University Press | Journal of Leukocyte Biology
... Mario Covas/Geraldo Alckmin (1999-2002); Geraldo Alckmin/Claudio Lembo (2003-2006) and finally Jose Serra (2007-2010). ...
Tópico(s): Business and Management Studies
2010 - UNIVERSIDADE METODISTA DE SÃO PAULO | Educação & Linguagem
Serena Lembo, L Panariello, Claudio Lembo, Fabio Ayala,
Contact DermatitisVolume 59, Issue 1 p. 59-60 Toilet contact dermatitis S. Lembo, Corresponding Author S. Lembo Department of Dermatology, “Federico II” University of Naples, via S. Pansini 5, 80131 Naples, ItalySerena LemboDepartment of Dermatology“Federico II” University of Naplesvia Pansini 580131 NaplesItalyTel: 0039 3392197801Fax: 0039 0817462442e-mail: [email protected]Search for more papers by this authorL. Panariello, L. Panariello Department of Dermatology, “Federico II” University of Naples, ...
Tópico(s): Occupational exposure and asthma
2008 - Wiley | Contact Dermatitis
Serena Lembo, Claudio Lembo, Cataldo Patruno, Pasquale Cuomo, Fabio Ayala, Nicola Balato, Anna Balato,
Contact sensitization (CS) and allergic contact dermatitis (ACD) were once thought to be rare in children. The aim of our study was to assess CS and ACD in children affected by eczematous conditions referring to our contact and occupational dermatoses service, and to compare the obtained data to the results of a similar study performed in our Department in late Eighties.A retrospective analysis of Patch Test data from the Database of Contact Allergy of the Department of Dermatology, University Federico ...
Tópico(s): Allergic Rhinitis and Sensitization
2018 - | Italian Journal of Dermatology and Venereology
Serena Lembo, Chiara De Leonibus, Maria Grazia Francia, Claudio Lembo, Fabio Ayala,
To the Editor: A 17-year-old Italian male with Down syndrome presented to the dermatology department with a 2-cm ulcerative lesion on the right tip of his tongue (Fig 1). The onset was about 7 days earlier with mild swelling. The patient's parents described a persistent vesicular eruption in the same area during the previous 2 months. They attributed it to biting and self-inflicted injuries and treated it with multiple but inefficacious drugs (nystatin, metisoprinol, diflucortolone, and chloramphenicol). ...
Tópico(s): Oral and gingival health research
2011 - Elsevier BV | Journal of the American Academy of Dermatology
Giulio Selvetella, Antonella Notte, Angelo Maffei, Valentina Calistri, Virginia Scamardella, Giacomo Frati, Bruno Trimarco, Claudio Colonnese, Giuseppe Lembo,
It has been demonstrated that left ventricular hypertrophy (LVH) confers an increased risk for major cerebrovascular events. However, it is still uncertain whether there is an association between LVH and asymptomatic cerebrovascular damage in hypertensive patients. In this study, we investigated the relation between LVH, evaluated by both echocardiography (Echo-LVH) and electrocardiography (ECG-LVH), and preclinical cerebral damage, as identified by magnetic resonance imaging.One hundred ninety-five ...
Tópico(s): Blood Pressure and Hypertension Studies
2003 - Lippincott Williams & Wilkins | Stroke
Katiuscia Nardi, Giordana Pelone, Michelangelo Bartolo, Maria Rita Di Ruzza, Marianna Storto, Antonella Notte, Giovanni Grillea, Claudio Colonnese, Giuseppe Lembo, Carmine Vecchione,
The objective of this study is to report a new manifestation of acute stroke following antifibrinolytic agent administration in young women carrying heterozygosity for methylene-tetrahydrofolate reductase (MTHFR) C677T. The study included two young women who developed an acute ischaemic stroke following three days of tranexamic acid administration for bleeding gynaecological disorders. Case 1, a 44-year-old woman, presented left hemiplegia, mild dysarthria and anosognosia. Brain magnetic resonance ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2011 - SAGE Publishing | Annals of Clinical Biochemistry International Journal of Laboratory Medicine
Marisa Gariglio, Paola Foresta, Cláudio Tavares Sacchi, M Lembo, Laura Hertel, Santo Landolfo,
The high mobility group (HMG-1) box proteins bind both non-B-DNA conformations and specific nucleotide sequences. They have been implicated in a wide variety of cellular functions involving DNA, such as transcription, replication and recombination. To determine whether HMG-1 box protein T160 plays a role in virus replication, we employed an antisense strategy to inhibit its expression in NIH 3T3 cells. The two T160 clones that expressed levels of T160 50% lower than those expressed by clones transfected ...
Tópico(s): Viral-associated cancers and disorders
1997 - Microbiology Society | Journal of General Virology
Maria Concetta Fargnoli, Federico Bardazzi, Luca Bianchi, Paolo Dapavo, Gabriella Fabbrocini, Paolo Gisondi, Giuseppe Micali, Anna Maria Offidani, Giovanni Pellacani, Nevena Skroza, Rosa Giuseppa Angileri, Martina Burlando, Anna Campanati, Carlo Giovanni Carrera, Andrea Chiricozzi, Andrea Conti, Clara De Simone, Vito Di Lernia, Enzo Errichetti, Marco Galluzzo, Claudio Guarneri, Claudia Lasagni, Serena Lembo, Francesco Loconsole, Matteo Megna, Maria Letizia Musumeci, Francesca Prignano, Antonio Giovanni Richetta, Emanuele Trovato, Marina Venturini, Ketty Peris, Piergiacomo Calzavara‐Pinton,
Brodalumab is a recombinant, fully human immunoglobulin IgG2 monoclonal antibody specifically targeted against interleukin-17RA that has been approved for the treatment of moderate-to-severe psoriasis in Europe. We developed a Delphi consensus document focused on brodalumab for the treatment of moderate-to-severe psoriasis. Based on published literature and their clinical experience a steering committee drafted 17 statements covering 7 domains specific to the treatment of moderate-to-severe psoriasis ...
Tópico(s): Delphi Technique in Research
2023 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Claudio Lembo, A. Raimondo, Amato de Paulis, Ilaria Mormile, Francesca Wanda Rossi, Serena Lembo, Anna Balato,
Psoriasis and psoriatic arthritis (PsA) are interrelated inflammatory diseases. Psoriasis usually precedes PsA onset and represents a well-established risk factor for PsA development. Bone erosion is a hallmark of PsA, and the contribution of cutaneous psoriatic inflammation in this process has been demonstrated. However, little is still known on the pathogenetic mechanisms that link psoriatic skin to joint damage. Clinical features of psoriatic disease, including specific body site involvement, ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2021 - Wiley | Experimental Dermatology
Carlo Peretto, Julie Arnaud, Jacopo Moggi‐Cecchi, Giorgio Manzi, Sébastien Nomade, Alison Pereira, Christophe Falguères, Jean‐Jacques Bahain, Dominique Grimaud‐Hervé, Claudio Berto, Benedetto Sala, Giuseppe Lembo, Brunella Muttillo, Rosalia Gallotti, Ursula Thun Hohenstein, Carmela Vaccaro, Mauro Coltorti, Marta Arzarello,
Isernia La Pineta (south-central Italy, Molise) is one of the most important archaeological localities of the Middle Pleistocene in Western Europe. It is an extensive open-air site with abundant lithic industry and faunal remains distributed across four stratified archaeosurfaces that have been found in two sectors of the excavation (3c, 3a, 3s10 in sect. I; 3a in sect. II). The prehistoric attendance was close to a wet environment, with a series of small waterfalls and lakes associated to calcareous ...
Tópico(s): Archaeology and ancient environmental studies
2015 - Public Library of Science | PLoS ONE
Aliaksei Kisialiou, Rodolfo Grella, Albino Carrizzo, Giordana Pelone, Michelangelo Bartolo, Chiara Zucchella, Francesco Rozza, Giovanni Grillea, Claudio Colonnese, Luigi Formisano, Maria Lembo, Annibale Alessandro Puca, Carmine Vecchione,
Acute ischemic stroke (AIS) is influenced by gender, age, and the brain site affected. Better characterization of AIS is necessary for improving guidelines, prevention, and destination of resources.Demographics, prestroke conditions, etiology, subtypes, specific hospital outcome, clinical and laboratory parameters, and mortality rates were prospectively registered in 105 southern Italian patients.AIS became more frequent in women than in men after age 65 years. Cryptogenic AIS decreased with age ...
Tópico(s): Cerebral Venous Sinus Thrombosis
2014 - Elsevier BV | Journal of the Neurological Sciences
Giuseppe Lembo, Antonella Signorini, Antonella Marone, Claudio Carbone, A. Agostini,
This study aimed at evaluating the economic performances of and carbon footprint associated with innovative systems for the energetic valorization of second cheese whey (SCW), a by-product of whey cheese manufacture, through anaerobic digestion processes. Three systems were modeled: a conventional single-stage anaerobic digester (FAD), located at about 50 km from the dairy factory; an on-site conventional single-stage anaerobic digester (CAD), located at the dairy industry; and an on-site two-stage ...
Tópico(s): Food Waste Reduction and Sustainability
2022 - Multidisciplinary Digital Publishing Institute | Energies
Raffaela Pero, Dario Palmieri, Tiziana Angrisano, Teresa Valentino, Antonio Federico, Renato Franco, Francesca Lembo, Andres J. Klein‐Szanto, Luigi Del Vecchio, Donatella Montanaro, Simona Keller, Claudio Arra, Vasiliki Papadopoulou, Simon D. Wagner, Carlo M. Croce, Alfredo Fusco, Lorenzo Chiariotti, Monica Fedele,
The PATZ1 gene encoding a POZ/AT-hook/Kruppel zinc finger (PATZ) transcription factor, is considered a cancer-related gene because of its loss or misexpression in human neoplasias. As for other POZ/domain and Kruppel zinc finger (POK) family members, the transcriptional activity of PATZ is due to the POZ-mediated oligomer formation, suggesting that it might be not a typical transactivator but an architectural transcription factor, thus functioning either as activator or as repressor depending on the ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2012 - Elsevier BV | Journal of Biological Chemistry
Matteo Megna, Cataldo Patruno, Maria Rita Bongiorno, Alessio Gambardella, Claudio Guarneri, Caterina Foti, Serena Lembo, Francesco Loconsole, Gabriella Fabbrocini,
Some biologics for psoriasis, especially anti-tumor necrosis factor (TNF)-α therapies, may re-activate latent tuberculosis (TBC) infection with consequent morbidity and mortality. However, there is a low reported incidence of conversion to positive TBC status among patients with psoriasis treated with second-generation biologic therapies, particularly anti-interleukin (IL)-17 therapies such as secukinumab.To evaluate the safety profile of secukinumab in psoriasis patients with latent TBC infection. ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2022 - Informa | Journal of Dermatological Treatment
Chiara De Leonibus, Claudio Lembo, Alfredo Santantonio, Tiziana Fioretti, Silvana Rojo, Francesco Salvatore, Massimiliano De Vivo, Gabriella Esposito, Paola Giliberti,
Lamellar ichthyosis is a rare congenital disorder characterized by collodion membrane at birth and facial anomalies (eclabium and ectropion).The major underlying genetic defect is in TGM1, with mutations of this gene found in 50% of patients.An early diagnosis is fundamental in view of establishing a specific treatment due to the severity of the disease.We report a case of severe lamellar ichthyosis and arthrogryposis, without the typical facial presentation, negative for TGM1 mutations.The clinical ...
Tópico(s): Cell Adhesion Molecules Research
2015 - | Journal of Dermatological Case Reports
Marco Cesati, Francesca Scatozza, Daniela D’Arcangelo, Gian Carlo Antonini-Cappellini, Stefania Rossi, Claudio Tabolacci, Maurizio Nudo, Enzo Palese, Luigi Lembo, Giovanni Di Lella, Francesco Facchiano, Antonio Facchiano,
The identification of reliable and quantitative melanoma biomarkers may help an early diagnosis and may directly affect melanoma mortality and morbidity. The aim of the present study was to identify effective biomarkers by investigating the expression of 27 cytokines/chemokines in melanoma compared to healthy controls, both in serum and in tissue samples. Serum samples were from 232 patients recruited at the IDI-IRCCS hospital. Expression was quantified by xMAP technology, on 27 cytokines/chemokines, ...
Tópico(s): vaccines and immunoinformatics approaches
2020 - Multidisciplinary Digital Publishing Institute | Cancers
Serena Lembo, Angela Patrì, Claudio Lembo, Anna Balato,
Journal of the European Academy of Dermatology and VenereologyVolume 29, Issue 6 p. 1237-1238 Letter to the Editor Surprise from skin nodules after travel to South America S. Lembo, S. Lembo Department of Clinical Medicine and Surgery – Section of Dermatology, University of Naples Federico II, Naples, ItalySearch for more papers by this authorA. Patrì, Corresponding Author A. Patrì Department of Clinical Medicine and Surgery – Section of Dermatology, University of Naples Federico II, Naples, ItalyCorrespondence: ...
Tópico(s): Viral Infections and Vectors
2014 - Wiley | Journal of the European Academy of Dermatology and Venereology
Alessandro Marcello, Andrea Civra, Rafaela Milan Bonotto, Lais Nascimento Alves, Sreejith Rajasekharan, Chiara Giacobone, Claudio Caccia, Roberta Cavalli, Marco Adami, Paolo Brambilla, David Lembo, Giuseppe Poli, Valerio Leoni,
There is an urgent need to identify antivirals against the coronavirus SARS-CoV-2 in the current COVID-19 pandemic and to contain future similar emergencies early on. Specific side-chain cholesterol oxidation products of the oxysterols family have been shown to inhibit a large variety of both enveloped and non-enveloped human viral pathogens. Here we report on the in vitro inhibitory activity of the redox active oxysterol 27-hydroxycholesterol against SARS-CoV-2 and against one of the common cold ...
Tópico(s): COVID-19 Clinical Research Studies
2020 - Elsevier BV | Redox Biology
Giovanni Almadori, Mario Rigante, Francesco Bussu, Claudio Parrilla, Roberto Gallus, Liliana Barone‐Adesi, Jacopo Galli, Gaetano Paludetti, Marzia Salgarello,
The aim of this study was to investigate the oncological outcomes in patients affected by oral carcinoma treated with radical compartmental surgery followed by microvascular flap reconstruction. We conducted a retrospective analysis on a cohort of 130 patients. All patients underwent ablative tumour resection (compartmental surgery) followed by immediate reconstruction with free flaps and adjuvant chemoradiotherapy, when necessary according to our tumour board and international guidelines. Disease- ...
Tópico(s): Ear and Head Tumors
2015 - Pacini Editore Medicina | Acta Otorhinolaryngologica Italica
Claudia Cristiano, Claudio Pirozzi, Lorena Coretti, Gina Cavaliere, Adriano Lama, Roberto Russo, Francesca Lembo, Maria Pina Mollica, Rosaria Meli, Antonio Calignano, Giuseppina Mattace Raso,
Autism spectrum disorders (ASD) are a group of heterogeneous neurodevelopmental conditions characterized by impaired social interaction, and repetitive stereotyped behaviours. Interestingly, functional and inflammatory gastrointestinal diseases are often reported as a comorbidity in ASDs, indicating gut-brain axis as a novel emerging approach. Recently, a central role for peroxisome-proliferator activated receptor (PPAR)-α has been addressed in neurological functions, associated with the behaviour. ...
Tópico(s): Child Nutrition and Feeding Issues
2018 - Elsevier BV | Brain Behavior and Immunity
Cristina Tintori, Giulia Iovenitti, Elisa Rita Ceresola, Roberto Ferrarese, Claudio Zamperini, Annalaura Brai, Giulio Poli, Elena Dreassi, Valeria Cagno, David Lembo, Filippo Canducci, Maurizio Botta,
Although highly active antiretroviral therapies (HAART) remarkably increased life expectancy of HIV positive people, the rate of novel HIV-1 infections worldwide still represent a major concern. In this context, pre-exposure prophylaxis (PrEP) approaches such as vaginal microbicide gels topically releasing antiretroviral drugs, showed to have a striking impact in limiting HIV-1 spread. Nevertheless, the co-presence of other genital infections, particularly those due to HSV-1 or 2, constitute a serious ...
Tópico(s): Reproductive tract infections research
2018 - Public Library of Science | PLoS ONE
Valeria Cagno, Andrea Civra, Daniela Rossin, Simone Calfapietra, Claudio Caccia, Valerio Leoni, Nicholas Dorma, Fiorella Biasi, Giuseppe Poli, David Lembo,
Oxysterols are known pleiotropic molecules whose antiviral action has been recently discovered. Here reported is the activity of a panel of oxysterols against HSV-1 with the identification of a new mechanism of action. A marked antiviral activity not only of 25HC but also of 27HC against HSV-1 was observed either if the oxysterols were added before or after infection, suggesting an activity unrelated to the viral entry inhibition as proposed by previous literature. Therefore, the relation between ...
Tópico(s): Immune Response and Inflammation
2017 - Elsevier BV | Redox Biology
Giulia Piazzi, Giuseppe D’Argenio, Anna Prossomariti, Vincenzo Lembo, G. Mazzone, Marco Candela, Elena Biagi, Patrizia Brigidi, Paola Vitaglione, Vincenzo Fogliano, Leonarda D’Angelo, Chiara Fazio, Alessandra Munarini, Andrea Belluzzi, Claudio Ceccarelli, Pasquale Chieco, Tiziana Balbi, Paul M. Loadman, Mark A. Hull, Marco Romano, Franco Bazzoli, Luigi Ricciardiello,
Inflammatory bowel diseases are associated with increased risk of developing colitis-associated colorectal cancer (CAC). Epidemiological data show that the consumption of ω-3 polyunsaturated fatty acids (ω-3 PUFAs) decreases the risk of sporadic colorectal cancer (CRC). Importantly, recent data have shown that eicosapentaenoic acid-free fatty acid (EPA-FFA) reduces polyp formation and growth in models of familial adenomatous polyposis. However, the effects of dietary EPA-FFA are unknown in CAC. We tested ...
Tópico(s): RNA modifications and cancer
2014 - Wiley | International Journal of Cancer