Chiara Ruocco, Maurizio Ragni, Fabio Rossi, Pierluigi Carullo, Veronica Ghini, Fabiana Piscitelli, Adele Cutignano, Emiliano Manzo, Rafael M. Ioris, Franck Bontems, Laura Tedesco, Carolina M. Greco, Annachiara Pino, Ilenia Severi, Dianxin Liu, Ryan P. Ceddia, Luisa Ponzoni, Leonardo Tenori, Lisa Rizzetto, Matthias Scholz, Kieran Tuohy, Francesco Bifari, Vincenzo Di Marzo, Claudio Luchinat, Michele O. Carruba, Saverio Cinti, Ilaria Decimo, Gianluigi Condorelli, Roberto Coppari, Sheila Collins, Alessandra Valerio, Enzo Nisoli,
Reduced activation of energy metabolism increases adiposity in humans and other mammals. Thus, exploring dietary and molecular mechanisms able to improve energy metabolism is of paramount medical importance because such mechanisms can be leveraged as a therapy for obesity and related disorders. Here, we show that a designer protein-deprived diet enriched in free essential amino acids can 1) promote the brown fat thermogenic program and fatty acid oxidation, 2) stimulate uncoupling protein 1 (UCP1)- ...
Tópico(s): Muscle metabolism and nutrition
2020 - American Diabetes Association | Diabetes
Davide Soldini, Hugo Zwahlen, Luca Gabutti, A Marzo, Claudio Marone,
Tópico(s): Dialysis and Renal Disease Management
2005 - Springer Science+Business Media | European Journal of Clinical Pharmacology
Gian Paolo Spinelli, Evelina Miele, Alessandra Anna Prete, Giuseppe Lo Russo, A. Di Marzo, Claudio Di Cristofano, Federica Tomao,
Adenoid cystic carcinoma of the trachea is a rare tumor, characterized by slow growth and low rate of local and distant metastasis. When achievable, complete surgical resection represents the optimal treatment approach, with the highest results in terms of overall survival. Radiation therapy is a reasonable alternative in cases of inoperable disease. We report a case of an 82-year-old white man affected by primary adenoid cystic carcinoma of the trachea, treated with debulking surgery and radiotherapy ...
Tópico(s): Tracheal and airway disorders
2019 - BioMed Central | Journal of Medical Case Reports
Martina Di Bartolomeo, Tibor Štark, Serena Di Martino, Fabio Arturo Iannotti, Jana Kučerová, Giovanni Luca Romano, Martin Kuchař, Samuele Laudani, Petr Palivec, Fabiana Piscitelli, Carsten T. Wotjak, Claudio Bucolo, Filippo Drago, Vincenzo Di Marzo, Claudio D’Addario, Vincenzo Micale,
Adolescent exposure to cannabinoids as a postnatal environmental insult may increase the risk of psychosis in subjects exposed to perinatal insult, as suggested by the two-hit hypothesis of schizophrenia. Here, we hypothesized that peripubertal Δ9-tetrahydrocannabinol (aTHC) may affect the impact of prenatal methylazoxymethanol acetate (MAM) or perinatal THC (pTHC) exposure in adult rats. We found that MAM and pTHC-exposed rats, when compared to the control group (CNT), were characterized by adult phenotype ...
Tópico(s): Neuroscience of respiration and sleep
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Giordano De Marzo, Andrea Zaccaria, Claudio Castellano,
The flourishing of fake news is favored by recommendation algorithms of online social networks which, based on previous users activity, provide content adapted to their preferences and so create filter bubbles. We introduce an analytically tractable voter model with personalized information, in which an external field tends to align the agent opinion with the one she held more frequently in the past. Our model shows a surprisingly rich dynamics despite its simplicity. An analytical mean-field approach, ...
Tópico(s): Misinformation and Its Impacts
2020 - American Physical Society | Physical Review Research
Antonio Buondonno, Pasquale Avella, Micaela Cappuccio, Andrea Scacchi, Roberto Vaschetti, Giancarlo Di Marzo, Pietro Maida, Claudio Luciani, Bruno Amato, Maria Chiara Brunese, Daniela Espósito, Lucio Selvaggi, Germano Guerra, Aldo Rocca,
Metabolic and bariatric surgery (BS) are considered life-changing and life-saving treatments for obese patients. The Italian Society of Obesity Surgery (SICOB) requires at least 25 operations per year to achieve the standard of care in the field. Despite the increasing need to treat obese patients, some small southern regions of Italy, such as Molise, do not have enough experience in bariatric procedures to be allowed to perform them. Therefore, our aim was to run a Hub and Spoke Program with a referral ...
Tópico(s): Esophageal Cancer Research and Treatment
2022 - Frontiers Media | Frontiers in Surgery
Gianluca Pontone, Andrea Igoren Guaricci, Laura Fusini, Andrea Baggiano, Marco Guglielmo, Giuseppe Muscogiuri, Alessandra Volpe, Raffaele Abete, Giovanni Donato Aquaro, Andrea Barison, Jan Bogaert, Giovanni Camastra, Samuela Carigi, Nazario Carrabba, Grazia Casavecchia, Stefano Censi, Gloria Cicala, Carlo N. De Cecco, Manuel De Lazzari, Gabriella Di Giovine, Mauro Roma, Monica Dobrovie, Marta Focardi, Nicola Gaibazzi, Annalaura Gismondi, Matteo Gravina, Chiara Lanzillo, Massimo Lombardi, Valentina Lorenzoni, Jordi Lozano-Torres, Chiara Martini, Francesca Marzo, Ambra Masi, Riccardo Memeo, Claudio Moro, Alberto Nese, Alessandro Palumbo, Anna Giulia Pavon, Patrizia Pedrotti, Martina Perazzolo Marra, Silvia Pica, Silvia Pradella, Cristina Presicci, Mark Rabbat, Claudia Raineri, José F. Rodríguez‐Palomares, Stefano Sbarbati, U. Joseph Schoepf, Angelo Squeri, Nicola Sverzellati, Rolf Symons, Emily Tat, Mauro Timpani, Giancarlo Todiere, Adele Valentini, Ákos Varga‐Szemes, Pier Giorgio Masci, Juerg Schwitter,
Implantable cardioverter-defibrillator (ICD) therapy is the most effective prophylactic strategy against sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM) and left ventricle ejection fraction (LVEF) ≤35% as detected by transthoracic echocardiograpgy (TTE). This approach has been recently questioned because of the low rate of ICD interventions in patients who received implantation and the not-negligible percentage of patients who experienced SCD despite not fulfilling criteria for ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2023 - Elsevier BV | JACC. Cardiovascular imaging
Giuseppe Giannini, Mauro Marzi, R Pezzi, Tiziana Brunetti, Gianfranco Battistuzzi, Maria Di Marzo, Walter Cabri, Loredana Vesci, Claudio Pisano,
With the aim to discover novel HDAC inhibitors with high potency and good safety profiles, we have designed a small library based on a N-hydroxy-(4-oxime)-cinnamide scaffold. We describe the synthesis of these novel compounds and some preliminary in vitro cytotoxic activity on three tumor cell lines, NB4, H460 and HCT116, as well as their inhibitory activity against class I, II and IV HDAC. Several 4-oxime derivatives demonstrated a promising inhibitory activity on HDAC6 and HDAC8 coupled to a good ...
Tópico(s): Click Chemistry and Applications
2009 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Giulio Iannelli, Giordano De Marzo, Claudio Castellano,
Social media influence online activity by recommending to users content strongly correlated with what they have preferred in the past. In this way, they constrain users within filter bubbles strongly limiting their exposure to new or alternative content. We investigate this type of dynamics by considering a multistate voter model where, with a given probability λ, a user interacts with "personalized information," suggesting the opinion most frequently held in the past. By means of theoretical arguments ...
Tópico(s): Social Media and Politics
2022 - American Institute of Physics | Chaos An Interdisciplinary Journal of Nonlinear Science
Martina Di Bartolomeo, Tibor Štark, Oriana Maria Maurel, Fabio Arturo Iannotti, Martin Kuchař, Jana Kučerová, Fabiana Piscitelli, Samuele Laudani, Vladimír Pekařík, Salvatore Salomone, Beatrice Arosio, Raphael Mechoulam, Mauro Maccarrone, Filippo Drago, Carsten T. Wotjak, Vincenzo Di Marzo, Matteo Vismara, Bernardo Dell’Osso, Claudio D’Addario, Vincenzo Micale,
Perinatal exposure to Δ9-tetrahydrocannabinol (THC) affects brain development and might increase the incidence of psychopathology later in life, which seems to be related to a dysregulation of endocannabinoid and/or dopaminergic systems. We here evaluated the transcriptional regulation of the genes encoding for the cannabinoid CB1 receptor (Cnr1) and the dopamine D2 receptor (Drd2) in perinatal THC-(pTHC) exposed male rats, focusing on the role of DNA methylation analyzed by pyrosequencing. Simultaneously, ...
Tópico(s): Pancreatic function and diabetes
2020 - Elsevier BV | Pharmacological Research
Davide Pietropaoli, Rita Del Pinto, Claudio Ferri, Giuseppe Marzo, Mario Giannoni, Eleonora Ortu, Annalisa Monaco,
Periodontitis is a relapsing-remitting disease. Compared with bleeding on probing (BoP), expression of disease activity, periodontal inflamed surface area (PISA), incorporates chronic disease parameters. We tested the association of PISA and BoP with blood pressure (BP) in NHANES III.A total of 8,614 subjects (≥30 years) with complete periodontal and BP examinations were enrolled. PISA was derived from periodontal probing depth and BoP. The association of PISA and BoP with high/uncontrolled BP was examined ...
Tópico(s): Dental Radiography and Imaging
2019 - Wiley | Journal Of Clinical Periodontology
Claudio Ferri, E Marzo, G. Longombardo, L La Civita, Fabrizio Lombardini, Dilia Giuggioli, Renato Vanacore, A. M. Liberati, Alessandro Mazzoni, Francesco Greco,
To confirm the positive results of a preliminary trial, 26 patients with mixed cryoglobulinaemia were enrolled in a controlled, randomised, crossover trial with interferon alfa-2b. A significant improvement was seen in the purpura score and alanine aminotransferase activities during six months9 treatment, and was associated with a significant decrease in cryocrit and a returning to normal of the lymphocyte CD4/CD8 ratio (in eight of nine patients). No significant variations were seen during the six ...
Tópico(s): Hepatitis B Virus Studies
1993 - BMJ | Gut
Alessandro Antonelli, Carlotta Palumbo, Alessandro Veccia, Simona Fisogni, Stefania Zamboni, Maria Furlan, Simone Francavilla, Marco Lattarulo, Enrico De Marzo, Giuseppe Mirabella, Angelo Peroni, Claudio Simeone,
Tópico(s): Reconstructive Surgery and Microvascular Techniques
2018 - Springer Science+Business Media | Journal of Robotic Surgery
Subhi J. Al’Aref, Ahmed Altibi, Abdallah Malkawi, Munthir Mansour, Lohendran Baskaran, Ahmad Masri, Hind Rahmouni, Raffaele Abete, Daniele Andreini, Giovanni Donato Aquaro, Andrea Barison, Jan Bogaert, Giovanni Camastra, Samuela Carigi, Nazario Carrabba, Grazia Casavecchia, Stefano Censi, Gloria Cicala, Edoardo Conte, Carlo N. De Cecco, Manuel De Lazzari, Gabriella Di Giovine, Mauro Roma, Monica Dobrovie, Marta Focardi, Nicola Gaibazzi, Annalaura Gismondi, Matteo Gravina, Marco Guglielmo, Chiara Lanzillo, Massimo Lombardi, Valentina Lorenzoni, Jordi Lozano-Torres, Davide Margonato, Chiara Martini, Francesca Marzo, Pier Giorgio Masci, Ambra Masi, Riccardo Memeo, Claudio Moro, Saima Mushtaq, Alberto Nese, Alessandro Palumbo, Anna Giulia Pavon, Patrizia Pedrotti, Mauro Pepi, Martina Perazzolo Marra, Silvia Pica, Silvia Pradella, Cristina Presicci, Mark Rabbat, Claudia Raineri, José F. Rodríguez‐Palomares, Stefano Sbarbati, U. Joseph Schoepf, Angelo Squeri, Nicola Sverzellati, Rolf Symons, Emily Tat, Mauro Timpani, Giancarlo Todiere, Adele Valentini, Ákos Varga‐Szemes, Alessandra Volpe, Laura Fusini, Andrea Igoren Guaricci, Juerg Schwitter, Gianluca Pontone,
Right ventricular systolic dysfunction (RVSD) is an important determinant of outcomes in heart failure (HF) cohorts. While the quantitative assessment of RV function is challenging using 2D-echocardiography, cardiac magnetic resonance (CMR) is the gold standard with its high spatial resolution and precise anatomical definition. We sought to investigate the prognostic value of CMR-derived RV systolic function in a large cohort of HF with reduced ejection fraction (HFrEF).Study cohort comprised of patients ...
Tópico(s): Cardiac Imaging and Diagnostics
2022 - Oxford University Press | European Heart Journal - Cardiovascular Imaging
Nadia Casini, Iris Maria Forte, Gianmarco Mastrogiovanni, Francesca Pentimalli, Adriano Angelucci, Claudio Festuccia, Valentina Tomei, Elisa Ceccherini, Domenico Di Marzo, Silvia Schenone, Maurizio Botta, Antonio Giordano, Paola Indovina,
... Mastrogiovanni 1 , Francesca Pentimalli 2 , Adriano Angelucci 3 , Claudio Festuccia 3 , Valentina Tomei 1 , Elisa Ceccherini 1 , Domenico Di Marzo 2 , Silvia Schenone 4 , Maurizio Botta 5, 6 , ...
Tópico(s): RNA Research and Splicing
2015 - Impact Journals LLC | Oncotarget
Giuseppe Giannini, Mauro Marzi, Maria Di Marzo, Gianfranco Battistuzzi, R Pezzi, Tiziana Brunetti, Walter Cabri, Loredana Vesci, Claudio Pisano,
In order to gather further knowledge about the structural requirements on histone deacetylase inhibitors (HDACi), starting from the schematic model of the common pharmacophore that characterizes this class of molecules (surface recognition CAP group-connection unit-linker region-Zinc Binding Group), we designed and synthesized a series of hydroxamic acids containing a bis-(indolyl)methane moiety. HDAC inhibition profile and antiproliferative activity were evaluated.
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2009 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
A Marzo, Monia Fibbioli, Claudio Marone, Bernard Cerutti,
This study, based on computer simulations, analysed the degree of predictivity of pilot trials on six subjects, with the idea of a further pivotal trial on 18 or more volunteers aimed at assessing bioequivalence. Volunteers enrolled in 10 pivotal bioequivalence trials were considered. For every trial, a thousand bootstrap samples were generated to simulate trials with six subjects, while keeping a balanced design for sequence, period and formulation. Then a standard ANOVA for crossover trials, with ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2003 - Elsevier BV | Pharmacological Research
Claudio Corianó, Luigi Delle Rose, C. De Marzo,
We present a renormalization group study of the scalar potential in a minimal U(1) B−L extension of the Standard Model involving one extra heavier Higgs and three heavy right-handed neutrinos with family universal B-L charge assignments. We implement a type-I seesaw for the masses of the light neutrinos of the Standard Model. In particular, compared to a previous study, we perform a two-loop extension of the evolution, showing that two-loop effects are essential for the study of the stability of ...
Tópico(s): Quantum Chromodynamics and Particle Interactions
2016 - Springer Nature | Journal of High Energy Physics
Claudio Corianó, Luigi Delle Rose, C. De Marzo, M. Serino,
We extend a previous analysis on the derivation of the dilaton Wess-Zumino (WZ) action in $d=4$, based on the method of Weyl gauging, to $6$ dimensions. As in the previous case, we discuss the structure of the same action in dimensional regularization using 6-dimensional Weyl invariants, extracting the dilaton interactions in the most general scheme, with the inclusion of the local anomaly terms. As an application, we present the WZ action for the (2,0) tensor multiplet, which has been investigated ...
Tópico(s): Cosmology and Gravitation Theories
2014 - IOP Publishing | Classical and Quantum Gravity
Claudio Corianó, Luigi Delle Rose, C. De Marzo,
We investigate a minimal $U(1)'$ extension of the Standard Model with one extra complex scalar and generic gauge charge assignments. We use a type-I seesaw mechanism with three heavy right handed neutrinos to illustrate the constraints on the charges, on their mass and on the mixing angle of the two scalars, derived by requiring the vacuum stability of the scalar potential. We focus our study on a scenario which could be accessible at the LHC, by selecting a vacuum expectation value of the extra ...
Tópico(s): Quantum Chromodynamics and Particle Interactions
2014 - Elsevier BV | Physics Letters B
Giuseppe Giannini, Mauro Marzi, R Pezzi, Tiziana Brunetti, Gianfranco Battistuzzi, Maria Di Marzo, Walter Cabri, Loredana Vesci, Claudio Pisano,
Tópico(s): Histone Deacetylase Inhibitors Research
2009 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Federica Ragazzola, Agnese Marchini, Mario Adani, Andrea Bordone, Alberto Castelli, Gabriella Cerrati, Regina Kolzenburg, Joachim Langeneck, Carlotta di Marzo, Matteo Nannini, Giancarlo Raiteri, Elisa Romanelli, M. Mateo Santos, Claudio Vasapollo, Carlo Pipitone, Chiara Lombardi,
In coastal marine ecosystems coralline algae often create biogenic reefs. These calcareous algal reefs affect their associated invertebrate communities via diurnal oscillations in photosynthesis, respiration and calcification processes. Little is known about how these biogenic reefs function and how they will be affected by climate change. We investigated the winter response of a Mediterranean intertidal biogenic reef, Ellissolandia elongata exposed in the laboratory to reduced pH conditions (i.e. ...
Tópico(s): Coral and Marine Ecosystems Studies
2021 - Elsevier BV | Marine Environmental Research
Claudio Marzo Cavalcanti de Brito, Ruth Pastôra Saraiva Leão, Fernando Luiz Marcelo Antunes,
Este artigo avalia o ajuste de um sistema de proteção de um acionamento de velocidade variável de um motor de indução trifásico submetidos a afundamentos de tensão simétricos e assimétricos. Testes foram realizados para avaliar o comportamento da tensão no elo CC e da corrente de alimentação do acionamento de velocidade variável sob afundamentos de tensão com o intuito de estabelecer seus limites de tolerância. São analisadas as técnicas de regeneração de energia, adição de neutro, e aplicação de ...
Tópico(s): Power Quality and Harmonics
2005 - | Eletrônica de Potência
Luigi Petramala, Dario Cotesta, Paolo Sapienza, Laura Zinnamosca, Enrico Moroni, Luca di Marzo, Giorgio De Toma, Claudio Letizia,
We report a case of a 63-year-old man, with a previous history of hypertension and glucose intolerance associated troncular obesity that was emergently admitted to our Institution for evaluation of a severe, constant posterior chest pain which radiated anteriorly and dyspnoea with a suspected diagnosis of acute aortic dissection. A CT scan of thorax and abdomen demonstrated a dissection starting just below left succlavian artery and extending downward to the left renal artery, involving the celiac ...
Tópico(s): Cardiac Valve Diseases and Treatments
2009 - Elmer Press Inc. | Journal of Clinical Medicine Research
Rodolfo Gerónimo Carrillo, Karla Celene Ramos Rendón, Valentina Rivas Acuña, Griselda Hernández Ramírez, Yadira Mateo Crisóstomo,
... recolección de los datos fue desde febrero a marzo de 2016 en las instalaciones de las escuelas primarias Profesores Claudio Cortés Castro y Manuel Díaz Prieto de la ...
Tópico(s): Youth, Drugs, and Violence
2017 - Medwave Estudios Limitada | Medwave
Claudio Castellano, Simona Cabib, Antonella Palmisano, Vincenzo Di Marzo, Stefano Puglisi‐Allegra,
Post-training administration of anandamide (1.5, 3, 6 mg/kg) dose-dependently impairs the retention of an inhibitory avoidance response in mice. The effects on retention performance induced by the drug appear to be due to an effect on memory consolidation, as they were observed when drugs were given at short, but not long, periods of time after training, i.e. when the memory trace was susceptible to modulation. Pretreatment with either selective D1 or D2 dopamine (DA) receptor agonists, SKF 38393 ...
Tópico(s): Memory and Neural Mechanisms
1997 - Lippincott Williams & Wilkins | Behavioural Pharmacology
Claudio Corianó, Luigi Delle Rose, C. De Marzo, M. Serino,
We investigate the Standard Model in the nearly conformal limit, in which conformal symmetry is broken only by the dilatation anomaly, through a hierarchy of anomalous Ward identities for the divergence of its dilatation current. In this approximation, the identities allow to extract the coupling of the dilaton to the trace anomaly, which we compute up to the quartic order in the conformal breaking scale. Our approach can be easily extended to discuss the anomaly contributions to the dilaton effective ...
Tópico(s): Quantum Chromodynamics and Particle Interactions
2012 - Elsevier BV | Physics Letters B
Elena Accomando, Claudio Corianó, Luigi Delle Rose, Juri Fiaschi, C. De Marzo, Stefano Moretti,
We study a class of non-exotic minimal U(1)′ extensions of the Standard Model, which includes all scenarios that are anomaly-free with the ordinary fermion content augmented by one Right-Handed neutrino per generation, wherein the new Abelian gauge group is spontaneously broken by the non-zero Vacuum Expectation Value of an additional Higgs singlet field, in turn providing mass to a Z ′ state. By adopting the B − L example, whose results can be recast into those pertaining to the whole aforementioned ...
Tópico(s): Quantum Chromodynamics and Particle Interactions
2016 - Springer Nature | Journal of High Energy Physics
Tibor Štark, Fabio Arturo Iannotti, Serena Di Martino, Martina Di Bartolomeo, Jana Kučerová, Fabiana Piscitelli, Carsten T. Wotjak, Claudio D’Addario, Filippo Drago, Vincenzo Di Marzo, Vincenzo Micale,
In agreement with the neurodevelopmental hypothesis of schizophrenia, prenatal exposure of Sprague-Dawley rats to the antimitotic agent methylazoxymethanol acetate (MAM) at gestational day 17 produces long-lasting behavioral alterations such as social withdrawal and cognitive impairment in adulthood, mimicking a schizophrenia-like phenotype. These abnormalities were preceded at neonatal age both by the delayed appearance of neonatal reflexes, an index of impaired brain maturation, and by higher 2- ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2022 - Multidisciplinary Digital Publishing Institute | Biomolecules
Giacomo Tini, Paolo Milani, Mattia Zampieri, Angelo Giuseppe Caponetti, F Fabris, Andrea Foli, Alessia Argirò, Carlotta Mazzoni, Christian Gagliardi, Simone Longhi, Giulia Saturi, Giuseppe Vergaro, Alberto Aimo, Domitilla Russo, Guerino Giuseppe Varrà, Matteo Serenelli, Gioele Fabbri, Laura De Michieli, Giuseppe Palmiero, Giuseppe Ciliberti, Samuela Carigi, Eugenio Sessarego, Giulia Elena Mandoli, Giulia Ricci Lucchi, Valeria Rella, Enrico Monti, Elisa Gardini, Michela Bartolotti, Lia Crotti, Elisa Merli, Roberta Mussinelli, Pier Filippo Vianello, Matteo Cameli, Francesca Marzo, Federico Guerra, Giuseppe Limongelli, Alberto Cipriani, Stefano Perlini, Laura Obici, Federico Perfetto, Camillo Autore, Italo Porto, Claudio Rapezzi, Gianfranco Sinagra, Marco Merlo, Beatrice Musumeci, Michele Emdin, Elena Biagini, Francesco Cappelli, Giovanni Palladini, Marco Canepa,
Epidemiology of wild-type transthyretin cardiac amyloidosis (ATTRwt-CA) remains poorly defined. A better characterization of pathways leading to ATTRwt-CA diagnosis is of key importance, and potentially informative of disease course and prognosis. The aim of this study was to describe the characteristics of contemporary pathways leading to ATTRwt-CA diagnosis, and their potential association with survival.This was a retrospective study of patients diagnosed with ATTRwt-CA at 17 Italian referral centres ...
Tópico(s): Cellular transport and secretion
2023 - Elsevier BV | European Journal of Heart Failure