Silvia Bruno, Bernardetta Ledda, Claudya Tenca, Silvia Ravera, Anna Maria Orengo, Andrea Nicola Mazzarello, Elisa Pesenti, Salvatore Casciaro, Omar Racchi, Fabio Ghiotto, Cecilia Marini, Gianmario Sambuceti, Andrea DeCensi, Franco Fais,
// Silvia Bruno 1 , Bernardetta Ledda 1 , Claudya Tenca 1 , Silvia Ravera 2 , Anna Maria Orengo 3 , Andrea Nicola Mazzarello 1, 4 , Elisa Pesenti 1 , Salvatore Casciaro 5 , Omar Racchi ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2015 - Impact Journals LLC | Oncotarget
Jacob Appelbaum, April E. Price, Kaori Oda, Joy Zhang, Wai‐Hang Leung, Giacomo Tampella, Dong Xia, Pauline Pl So, Sarah K. Hilton, Claudya Evandy, Semanti Sarkar, Unja Martin, Anne-Rachel Krostag, Marissa Leonardi, Daniel E. Zak, Rachael Logan, Paula Lewis, Secil Franke-Welch, Njabulo Ngwenyama, Michael Fitzgerald, Niklas Tulberg, Stephanie D. Rawlings‐Rhea, Rebecca Gardner, Kyle M. L. Jones, Angelica Sanabria, William Crago, John C. Timmer, Andrew Hollands, Brendan P. Eckelman, Sanela Bilic, Jim Woodworth, Adam J. Lamble, Philip D. Gregory, Jordan Jarjour, Mark Pogson, Joshua A. Gustafson, Alexander Astrakhan, Michael C. Jensen,
Chimeric antigen receptor (CAR) designs that incorporate pharmacologic control are desirable, however designs suitable for clinical translation are needed. We designed a fully human, rapamycin-regulated, drug product for targeting CD33+ tumors called dimerization agent regulated immunoreceptor complex (DARIC33). T cell products demonstrated target specific and rapamycin-dependent cytokine release, transcriptional responses, cytotoxicity, and in vivo antileukemic activity in the presence of as little ...
Tópico(s): T-cell and B-cell Immunology
2024 - American Society for Clinical Investigation | Journal of Clinical Investigation
Fernando J. Martínez, MeiLan K. Han, Camden Lopez, Susan Murray, David M. Mannino, Stacey E. Anderson, Randall W. Brown, Rowena J Dolor, Nancy Elder, Min J. Joo, Irfan Khan, Lyndee Knox, Catherine A. Meldrum, Elizabeth Peters, Cathie Spino, Hazel Tapp, Byron Thomashow, Linda Zittleman, Barry J. Make, Barbara P. Yawn, Emily E. White, Cathy Scott, Megan Urbin, Jeffrey Holtzman, Alicia Morris, Anna Smyth, Stefan Jhagroo, Michelle LoPiccolo, Pete Amari, Claudya Greig, Brandon B. Holmes, Elisha Malanga, Sergio Martinez, Gretchen McCreary, C.B. Pasquale, Linda Walsh, Ruth Tal‐Singer, Malin Fagerås, Norbert Feigler, Angus Hamblin, Frank Trudo, Erin L. Tomaszewski, Alberto de la Hoz, Carl Abbott, Shahin Sanjar, Carlos Tafur, Carole Catapano, Kim Gilchrist, Nancy Kline Leidy, Lindsey Amendola, José M. Flores, Grace Ruh, Tammy Harvey, Ashleigh Skipper, Kate Walsh, Lauren Warsocki, Abm Shafayet, Cynthia Pinargotte, Melba Ventuera, Vikash Mandania, Donna Green, Luis Paredas, E I Barba, Erica Mezzasalma, Lindsey Williams, Jack Westfall, Jen Ancona, Lori Jarell, Megan Kaiser, Christin Sutter, Ranee Chatterjee, Chad Harrell, Taylor Harris, Kimberly Leathers, Beth Mancuso-Mills, Morgan Mangum, Nikita Shah, Brandon Leon, Matthew Leon, Patty Dionicio, Lindsay Shade, R Beasley, Andrea Price, Cody Oliver, Christy Flynn, Stephen Greenberg, Lindsay Lowe, Laura A. McAllister, Rina Leonidas, Katherine O’Hare, Kelsey Strout, Jérémy Thomas, Lyle J. Fagnan, Xaviera Martinez-Armenta, Lindsay Shankle, Martha Snow, Valeria Vazquez-Trejo, Lisa Tannikula, Ariel Leifer, Jonathan Radosta, Kyungran Shim, Christina E. Wells, Diane Garcia, Samantha Madrid, Esther Pacheco, Leonard Romo, Sara Nora Ross, E. Valle Velazquez, Natasha Brown, Gordon R. Bernard, Deborah R. Barnbaum, João A. de Andrade, Daren Knoel, Peter K. Lindenauer, André Rogatko, Marinella Temprosa,
Chronic obstructive pulmonary disease (COPD) is underdiagnosed in primary care.
Tópico(s): Nursing Diagnosis and Documentation
2023 - American Medical Association | JAMA
Claudya Morin, Sébastien Drolet, Carl Daigle, Isabelle Deshaies, Jean‐François Ouellet, Chad G. Ball, Elijah Dixon, Julie Marceau, Jean‐François Ouellet,
Tópico(s): Neuroendocrine Tumor Research Advances
2019 - Elsevier BV | HPB
Elena Gugiatti, Claudya Tenca, Silvia Ravera, Marina Fabbi, Fabio Ghiotto, Andrea Nicola Mazzarello, Davide Bagnara, Daniele Reverberi, Daniela Zarcone, Giovanna Cutrona, Adalberto Ibatici, Ermanno Ciccone, Zbigniew Darżynkiewicz, Franco Fais, Silvia Bruno,
Tópico(s): Pancreatic and Hepatic Oncology Research
2018 - Ferrata Storti Foundation | Haematologica
Cecilia Marini, Silvia Bruno, Francesco Fiz, Cristina Campi, Roberto Piva, Giovanna Cutrona, Serena Matis, Alberto Nieri, Maurizio Miglino, Adalberto Ibatici, Anna Maria Orengo, Anna Maria Massone, Carlo Emanuele Neumaier, Daniela de Totero, Paolo Giannoni, Matteo Bauckneht, Michele Pennone, Claudya Tenca, Elena Gugiatti, Alessandro Bellini, Anna Borra, Elisabetta Tedone, Hülya Efetürk, Francesca Rosa, Laura Emionite, Michele Cilli, Davide Bagnara, Valerio Brucato, Paolo Bruzzi, Michele Piana, Franco Fais, Gianmario Sambuceti,
Skeletal erosion has been found to represent an independent prognostic indicator in patients with advanced stages of chronic lymphocytic leukaemia (CLL). Whether this phenomenon also occurs in early CLL phases and its underlying mechanisms have yet to be fully elucidated. In this study, we prospectively enrolled 36 consecutive treatment-naïve patients to analyse skeletal structure and bone marrow distribution using a computational approach to PET/CT images. This evaluation was combined with the analysis ...
Tópico(s): Acute Myeloid Leukemia Research
2017 - Nature Portfolio | Scientific Reports
Luca Trentin, Silvia Bresolin, Emanuela Giarin, Michela Bardini, Valentina Serafin, Benedetta Accordi, Franco Fais, Claudya Tenca, Paola De Lorenzo, Maria Grazia Valsecchi, Giovanni Cazzaniga, Geertruy te Kronnie, Giuseppe Basso,
Abstract To induce and sustain the leukaemogenic process, MLL-AF4+ leukaemia seems to require very few genetic alterations in addition to the fusion gene itself. Studies of infant and paediatric patients with MLL-AF4+ B cell precursor acute lymphoblastic leukaemia (BCP-ALL) have reported mutations in KRAS and NRAS with incidences ranging from 25 to 50%. Whereas previous studies employed Sanger sequencing, here we used next generation amplicon deep sequencing for in depth evaluation of RAS mutations ...
Tópico(s): Acute Myeloid Leukemia Research
2016 - Nature Portfolio | Scientific Reports
Paolo Marcatili, Fabio Ghiotto, Claudya Tenca, Anna Chailyan, Andrea Nicola Mazzarello, Xiao‐Jie Yan, Monica Colombo, Emilia Albesiano, Davide Bagnara, Giovanna Cutrona, Fortunato Morabito, Silvia Bruno, Manlio Ferrarini, Nicholas Chiorazzi, Anna Tramontano, Franco Fais,
Abstract Ag selection has been suggested to play a role in chronic lymphocytic leukemia (CLL) pathogenesis, but no large-scale analysis has been performed so far on the structure of the Ag-binding sites (ABSs) of leukemic cell Igs. We sequenced both H and L chain V(D)J rearrangements from 366 CLL patients and modeled their three-dimensional structures. The resulting ABS structures were clustered into a small number of discrete sets, each containing ABSs with similar shapes and physicochemical properties. ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2013 - American Association of Immunologists | The Journal of Immunology
Francesca Schena, Stefano Volpi, Caterina E. Faliti, Federica Penco, Spartaco Santi, Michele Proietti, Ursula Schenk, Gianluca Damonte, Annalisa Salis, Marta Bellotti, Franco Fais, Claudya Tenca, Marco Gattorno, Hermann Eibel, Marta Rizzi, Klaus Warnatz, Marco Idzko, Cemil Korcan Ayata, Mirzokhid Rakhmanov, Thierry Galli, Alberto Martini, Marco Canossa, Fabio Grassi, Elisabetta Traggiai,
Immunoglobulin (Ig) isotype diversification by class switch recombination (CSR) is an essential process for mounting a protective humoral immune response.Ig CSR deficiencies in humans can result from an intrinsic B cell defect; however, most of these deficiencies are still molecularly undefined and diagnosed as common variable immunodeficiency (CVID).Here, we show that extracellular adenosine critically contributes to CSR in human naive and IgM memory B cells.In these cells, coordinate stimulation ...
Tópico(s): Cytomegalovirus and herpesvirus research
2013 - Cell Press | Cell Reports
Monica Colombo, Giovanna Cutrona, Daniele Reverberi, Silvia Bruno, Fabio Ghiotto, Claudya Tenca, Κώστας Σταματόπουλος, Anastasia Hadzidimitriou, Jenny Ceccarelli, Sandra Salvi, Simona Boccardo, Maria Grazia Calevo, Amleto De Santanna, Mauro Truini, Franco Fais, Manlio Ferrarini,
Abstract Marginal zone (MZ) B cells, identified as surface (s)IgM high sIgD low CD23 low/− CD21 + CD38 − B cells, were purified from human spleens, and the features of their V(D)J gene rearrangements were investigated and compared with those of germinal center (GC), follicular mantle (FM) and switched memory (SM) B cells. Most MZ B cells were CD27 + and exhibited somatic hypermutations (SHM), although to a lower extent than SM B cells. Moreover, among MZ B-cell rearrangements, recurrent sequences were observed, ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2013 - BioMed Central | Molecular Medicine
Silvia Bruno, Fabio Ghiotto, Claudya Tenca, Andrea Nicola Mazzarello, Marı́a Rosa Bono, Paola Luzzi, Salvatore Casciaro, Anna Grazia Recchia, Andrea DeCensi, Fortunato Morabito, Franco Fais,
The in vitro effects of the synthetic retinoid N-(4-hydroxyphenyl)retinamide (4HPR, fenretinide) on primary B-cell chronic lymphocytic leukemia (CLL) cells from previously untreated CLL patients were investigated. 4HPR promoted the intrinsic apoptotic pathway by reactive oxygen species (ROS) generation and was accompanied by drop of Mcl-1 protein expression. The latter was not attributable to transcriptional downregulation but to protein degradation mediated by jun N-terminal kinase activation, and ...
Tópico(s): Ubiquitin and proteasome pathways
2012 - Springer Nature | Leukemia
Rita Simone, Claudya Tenca, Franco Fais, Matteo Luciani, Giulio Rossi, Giampaola Pesce, Marcello Bagnasco, Danièle Saverino,
CTLA-4 is a key factor in regulating and maintaining self tolerance, providing a negative signal to the T cell and thus limiting immune responses. Several polymorphisms within the CTLA-4 gene have been associated with an increased risk of developing autoimmune diseases and, very recently, with susceptibility to human cancer. Acute lymphoblastic leukemia is a clonal disorder of lymphoid progenitors representing the most frequent malignancy of childhood. Here, we show the presence at significantly ...
Tópico(s): Diabetes and associated disorders
2012 - Public Library of Science | PLoS ONE
Fabio Ghiotto, Franco Fais, Claudya Tenca, Valeria Tomati, Fortunato Morabito, Salvatore Casciaro, Anna Mumot, Gabriele Zoppoli, Ermanno Ciccone, Silvio Parodi, Silvia Bruno,
B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in human adults of the Western world and no definitive cure is yet available. The disease is characterized by accumulation of clonal malignant B lymphocytes resistant to apoptosis. Strategies to hit the anti-apoptotic drift of the Bcl-2 family in B-CLL cells are being explored. A novel peptidomimetic based on the BH3 domain of the pro-apoptotic protein Bim and recently shown to exert significant apoptotic activity on acute myeloid ...
Tópico(s): Phagocytosis and Immune Regulation
2009 - Taylor & Francis | Cancer Biology & Therapy
Anna Corcione, Elisa Ferretti, Maria Bertolotto, Franco Fais, Lizzia Raffaghello, Andrea Gregorio, Claudya Tenca, Luciano Ottonello, Claudio Gambini, Gláucia C. Furtado, Sérgio A. Lira, Vito Pistoia,
Background Fractalkine/CX3CL1, a surface chemokine, binds to CX3CR1 expressed by different lymphocyte subsets. Since CX3CL1 has been detected in the germinal centres of secondary lymphoid tissue, in this study we have investigated CX3CR1 expression and function in human naïve, germinal centre and memory B cells isolated from tonsil or peripheral blood. Methodology/Principal Findings We demonstrate unambiguously that highly purified human B cells from tonsil and peripheral blood expressed CX3CR1 ...
Tópico(s): T-cell and B-cell Immunology
2009 - Public Library of Science | PLoS ONE
Davide Bagnara, Adalberto Ibatici, Mirko Corselli, Nadia Sessarego, Claudya Tenca, Amleto De Santanna, Andrea Nicola Mazzarello, Antonio Daga, Renzo Corvò, Giulio Rossi, Francesco Frassoni, Ermanno Ciccone, Franco Fais,
Background CD1d is a monomorphic antigen presentation molecule expressed in several hematologic malignancies. Alpha-galactosylceramide (α-GalCer) is a glycolipid that can be presented to cytotoxic CD1d-restricted T cells. These reagents represent a potentially powerful tool for cell mediated immunotherapy.Design and Methods We set up an experimental model to evaluate the use of adoptively transferred cytotoxic CD1d-restricted T cells and α-GalCer in the treatment of mice engrafted with CD1d+ lymphoid ...
Tópico(s): Immunotherapy and Immune Responses
2009 - Ferrata Storti Foundation | Haematologica
Claudya P. Arana, Ishwar K. Puri, Swarnendu Sen,
Since prepared substrates offer an appropriate method for the selective production of uniform arrays of aligned CNTs and CNFs, it is important to illustrate the influence of different catalysts on the resulting nanostructures. This investigation characterizes the activity of three catalysts—iron in alloyed form as stainless steel, nickel, and platinum—on carbon nanostructure formation under identical conditions in an ethylene/air nonpremixed flame. We have synthesized well-aligned multi-walled CNTs ( ...
Tópico(s): Graphene research and applications
2005 - Elsevier BV | Proceedings of the Combustion Institute
Claudya Tenca, Andrea Merlo, Estelle Merck, Elizabeth E. M. Bates, Danièle Saverino, Rita Simone, Daniela Zarcone, Giorgio Trinchieri, Carlo E. Grossi, Ermanno Ciccone,
Abstract Immature dendritic cells (DCs) derived from freshly isolated human monocytes were used to evaluate the effect of the inhibiting receptor CD85j (leukocyte Ig-like receptor-1/ILT2) on activation induced by cross-linking of the human osteoclast-associated receptor (hOSCAR). CD85j and hOSCAR were expressed consistently at the same density on monocytes and on monocyte-derived DCs (both immature and mature). Cross-linking of hOSCAR, which activates via the FcR-associated γ-chain, induced Ca2+ flux ...
Tópico(s): T-cell and B-cell Immunology
2005 - American Association of Immunologists | The Journal of Immunology
Andrea Merlo, Claudya Tenca, Franco Fais, Lorenzo Battini, Ermanno Ciccone, Carlo E. Grossi, Danièle Saverino,
ABSTRACT Class switching consists in the substitution of the heavy-chain constant region of immunoglobulin M (IgM) with that of IgG, IgA, or IgE. This enables antibodies to acquire new effector functions that are crucial to combat invading pathogens. Class switching usually requires engagement of CD40 on B cells by CD40 ligand (CD40L) on antigen-activated CD4 + T cells and the production of cytokines. The process must be regulated tightly because abnormal IgG and IgA production favors the onset of autoimmunity, ...
Tópico(s): Immunotherapy and Immune Responses
2005 - American Society for Microbiology | Clinical and Vaccine Immunology
Franco Fais, Claudya Tenca, Giuseppe Cimino, Valentina Coletti, Sabrina Zanardi, Davide Bagnara, Danièle Saverino, Daniela Zarcone, Giulio Rossi, Ermanno Ciccone, Carlo E. Grossi,
Acute lymphoblastic leukemia (ALL) is the most frequent malignancy of childhood. Although therapeutical advances have been achieved, some ALL subgroups still fare poorly. CD1d is a monomorphic molecule that provides a suitable target for immunotherapy in view of the characterization of a glycolipid, α-galactosylceramide (α-GalCer), capable of being presented to CD1d-restricted T cells with cytotoxic potential. We investigated CD1d expression in 80 pediatric B-cell precursor (BCP) ALL cases defined ...
Tópico(s): Neuroblastoma Research and Treatments
2005 - Springer Nature | Leukemia
Danièle Saverino, Fabio Ghiotto, Andrea Merlo, Silvia Bruno, Lorenzo Battini, Marzia Occhino, Massimo Maffei, Claudya Tenca, Stefano Pileri, Lucia Baldi, Marina Fabbi, Angela Bachi, Amleto De Santanna, Carlo E. Grossi, Ermanno Ciccone,
Abstract Immune evasion mechanisms of human CMV are known; however, the immune control of infection remains poorly elucidated. We show that interaction between the viral protein UL18 on infected cells and the invariant receptor CD85j/LIR-1/ILT2 expressed on CTL is relevant for the control of infection. Resting and activated CD8+ T cells lysed UL18 expressing cells, whereas cells infected with CMV defective for UL18 were not killed. Lysis was not dependent on CD8+ T cell Ag specificity, MHC-unrestricted ...
Tópico(s): Herpesvirus Infections and Treatments
2004 - American Association of Immunologists | The Journal of Immunology
Claudya P. Arana, Mariusz Pontoni, Swarnendu Sen, Ishwar K. Puri,
The conditions under which soot is formed vary widely and depend upon several factors, including pressure, temperature, fuel type, combustor geometry, and extent of premixing. Although it is known that partially premixed flames (PPFs) can become either more or less sooting than their nonpremixed or premixed counterparts, the impact of partial premixing on soot formation across a large equivalence ratio and flow range is still inadequately understood. Comprehensive experimental data are relatively ...
Tópico(s): Atmospheric chemistry and aerosols
2004 - Elsevier BV | Combustion and Flame
Thymic T cell maturation depends on interactions between thymocytes and cells of epithelial and hematopoietic lineages that control a selective process whereby developing T cells with inappropriate or self-reactive receptors die. Molecules involved in this process are the TCR expressed on thymocytes together with the CD3 complex and MHC-peptide on accessory cells. However, other molecules may favor or prevent death of thymocytes, thus playing a role in selection. CD38 is expressed by the majority ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2003 - Oxford University Press | International Immunology
Silvia Bruno, Claudya Tenca, Danièle Saverino, Ermanno Ciccone, Carlo E. Grossi,
Squamous cell carcinoma (SCC) is the end product of a multistep process characterized by a progression from normal epithelial cells through metaplastic or dysplastic intraepithelial changes that evolve into invasive cancer. Since retinamides have shown promising in vivo anti-tumoral activity, we studied effects and effector mechanisms of the synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) on squamous cells at progressing stages of tumorigenesis. To this end, an in vitro model of squamous ...
Tópico(s): NF-κB Signaling Pathways
2002 - Oxford University Press | Carcinogenesis
Andrea Mengarelli, Daniela Zarcone, Roberta Caruso, Claudya Tenca, Ippolita Rana, Rita Maria Pinto, Carlo E. Grossi, Giulio Rossi,
In view of the relevance of adhesion molecule expression for the mechanisms of homing, trafficking and spreading of malignant cells, we have investigated the expression of surface adhesion molecules in lymphoblasts from 57 acute lymphoblastic leukemia (ALL) cases and tried to correlate the adhesive phenotype with immunological typing, prognostic factors at diagnosis and clinical follow-up. Blasts from all cases expressed adhesion molecules at high rates. β1 integrin chain (CD18) was consistently found ...
Tópico(s): Blood disorders and treatments
2001 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
Andrea Merlo, Danièle Saverino, Claudya Tenca, Carlo E. Grossi, Silvia Bruno, Ermanno Ciccone,
ABSTRACT Antigen-specific cytolytic CD4 + T lymphocytes control Mycobacterium tuberculosis infection by secreting cytokines and by killing macrophages that have phagocytosed the pathogen. However, lysis of the latter cells promotes microbial dissemination, and other macrophages engulf the released bacteria. Subsequently, CD4 + T-cell-mediated killing of macrophages goes on, and this persistent process may hamper control of infection, unless regulatory mechanisms maintain a subtle balance between lysis ...
Tópico(s): Tuberculosis Research and Epidemiology
2001 - American Society for Microbiology | Infection and Immunity
Danièle Saverino, Marina Fabbi, Fabio Ghiotto, Andrea Merlo, Silvia Bruno, Daniela Zarcone, Claudya Tenca, Micaela Tiso, Giuseppe Santoro, Giuseppe Anastasi, David Cosman, Carlo E. Grossi, Ermanno Ciccone,
Abstract The inhibitory molecule CD85/LIR-1/ILT2 has been detected previously on the surface of a small proportion of T lymphocytes. In this study, evidence is provided that, although only a fraction of CD3+ cells are stained by mAb specific for CD85/LIR-1/ILT2 on their surface, this inhibitory receptor is present in the cytoplasm of all T lymphocytes, and that it is detectable on the surface of all T cell clones by the M402 mAb. Biochemical analyses further demonstrate that CD85/LIR-1/ILT2 is present ...
Tópico(s): IL-33, ST2, and ILC Pathways
2000 - American Association of Immunologists | The Journal of Immunology
Danièle Saverino, Claudya Tenca, Daniela Zarcone, Andrea Merlo, Anna Maria Megiovanni, Maria Teresa Valle, Fabrizio Manca, Carlo E. Grossi, Ermanno Ciccone,
Abstract Since the functional outcome of effector T lymphocytes depends on a balance between activatory and inhibitory receptors, we studied the ability of CTLA-4 (CD152) to inhibit the cytolytic function of CTL. In 22 TCRαβ+CD3+8+ CTL clones, activation induced by anti-CD3, anti-CD28, or anti-CD2 mAb was inhibited by anti-CD152 mAb in a redirected killing assay. In eight clones inhibition was >40%, in 10 it ranged between 20–40%, and in four it was <20%. This suggests the existence of a clonal ...
Tópico(s): Immunotherapy and Immune Responses
1999 - American Association of Immunologists | The Journal of Immunology
Giulio Rossi, Paola Marroni, M. Paganuzzi, Francesca Romana Mauro, Claudya Tenca, Daniela Zarcone, Andrea Velardi, S. Molica, CE Grossi,
Tópico(s): Carbohydrate Chemistry and Synthesis
1997 - Springer Nature | Leukemia
Giulio Rossi, Claudya Tenca, G Cerruti, A. Favre, Daniela Zarcone, Antonio Tabilio, Francesca Romana Mauro, Luciana Annino, C. E. Grossit,
Adhesion molecule expression on acute and chronic lymphoid leukemia cells of B lineage (B-ALL and B-CLL) may subserve several functions. Adhesion of leukemic cells to endothelial cells and to extracellular matrix components is relevant to homing, trafficking and spread of the malignant cells, and thus to clinical presentation, course and disease prognosis. Adhesive interactions between malignant cells and accessory cells, particularly stromal cells in the bone marrow environment, may support growth ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1994 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
Giulio Rossi, Daniela Zarcone, Francesca Romana Mauro, G Cerruti, Claudya Tenca, Antonio Puccetti, Franco Mandelli, CE Grossi,
Abstract Expression of surface adhesion molecules of the Ig superfamily (CD54 and CD58), of the integrin family (beta 1, beta 2, and beta 3 chains), of the selectin family (L-selectin), and of the lymphocyte homing receptor (CD44) was analyzed on B-cell chronic lymphocytic leukemia (B- CLL) cells from 74 patients. The aim of the study was the definition of phenotypically distinct disease subsets and the correlation of adhesion molecule phenotypes with clinical parameters. Expression of CD58 on B- CLL ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1993 - Elsevier BV | Blood