STRANGE TALES OF SMALL MEN: HOMUNCULI IN REPRODUCTION CLARA PINTO-CORREIA* Introduction Preformation or preformationism are the terms currently ... ofPatten'sFoundations ofEmbryology includes the drawing mentioned 226 Clara Pinto-Correia ¦ Homunculi in Reproduction above, with the note "Reproduction ...
Tópico(s): Reproductive Health and Technologies
1999 - Johns Hopkins University Press | Perspectives in biology and medicine
Philippe Collas, Clara Pinto‐Correia, F. Abel Ponce de León, James M. Robl,
We investigated the influence of the cell cycle stage of the nuclear donor on prematurely condensed chromatin (PCC) and spindle morphology and on chromosome constitution in rabbit nuclear transplant embryos. The configuration of PCC following nuclear transplantation with G1, early S, and late S phase donor nuclei (G1, early S, and late S transplants, respectively) was characterized in whole mounts and chromosome spreads. In addition, the influence of the donor cell cycle stage on chromosome constitution ...
Tópico(s): Chromosomal and Genetic Variations
1992 - Oxford University Press | Biology of Reproduction
Charles R. Long, P. Damiani, Clara Pinto‐Correia, Robert A. MacLean, R.T. Duby, James M. Robl,
The objective of these experiments was to evaluate factors affecting in vitro fertilization of bovine oocytes matured in vitro, and their subsequent development to blastocysts. In Expts 1 and 2, sperm concentration, spermatozoa and oocyte incubation time, motility enhancers and semen source were manipulated. Fluorescent microscopy of microtubules and chromatin was used to observe sperm penetration rate, sperm aster formation and chromatin decondensation. Oocyte penetration rates were affected by ...
Tópico(s): Ovarian function and disorders
1994 - Bioscientifica | Reproduction
Clara Pinto‐Correia, Dominic Poccia, Thomas Chang, James M. Robl,
During fertilization in most mammals, the penetrating sperm organizes an aster of microtubules. We have investigated the mechanisms underlying this function of the sperm by a series of experiments based on microinjection of isolated sperm midpieces into unfertilized oocytes. These midpieces contain antigens recognized by the MPM-2 antibody. These antigens, which are absent from the rest of the tail fraction, correspond to three phosphorylated polypeptides of 77, 81, and 85 kDa. Dephosphorylation ...
Tópico(s): Sperm and Testicular Function
1994 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Clara Pinto‐Correia, Philippe Collas, F. Abel Ponce de León, James M. Robl,
Abstract Artificial activation and nuclear transfer in rabbit oocytes have been used in past years in an attempt to develop viable techniques for cloning in cattle. The procedures established in our laboratory, using the rabbit as a model, consistently lead to high rates of development to the blastocyst stage. However, the rate of embryos developing to term is considerably lower. In the present study, we undertook a detailed immunocytochemical study of the patterns of both microtubules and chromatin ...
Tópico(s): Microtubule and mitosis dynamics
1993 - Wiley | Molecular Reproduction and Development
Charles R. Long, Clara Pinto‐Correia, R.T. Duby, F. Abel Ponce de León, M.P. Boland, J. F. Roche, James M. Robl,
Abstract Chromatin and microtubule configurations during the first cell cycle of bovine zygotes were analyzed by DNA staining and microtubule immunolocalization using an IVM/IVF system and oocytes matured and fertilized in vivo, in order to investigate the origin of the active centrosome and to characterize the nuclear and the cytoplasmic changes following bovine fertilization. Our results suggest that the paternal centrosome is active during early zygotic development, forming a conspicuous sperm ...
Tópico(s): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
1993 - Wiley | Molecular Reproduction and Development
Philippe Collas, Clara Pinto‐Correia, Dominic Poccia,
The dynamics of lamin disassembly and reassembly during sea urchin male pronuclear development in vitro was investigated. Using five anti-lamin antibodies, we monitored by immunofluorescence and immunoblotting the changes in lamins during sperm chromatin decondensation, nuclear envelope (NE) formation, and male pronuclear swelling in fertilized sea urchin egg cytoplasmic extracts. We report the existence of five proteins in sperm nuclei and swollen male pronuclei (p49, p54, p65, p72, p84) which react ...
Tópico(s): RNA Interference and Gene Delivery
1995 - Elsevier BV | Experimental Cell Research
Clara Pinto‐Correia, Charles R. Long, Thomas Chang, James M. Robl,
Abstract Mechanisms of nuclear reprogramming and assessment of potential malfunctions that could be deleterious for development were evaluated in rabbit zygotes, parthenotes, and nuclear transfer embryos by analysis of DNA replication, nucleolar fibrillarin label, and localization of nuclear material reactive to the MPM‐2 antibody. Nuclear transfer embryos were derived from G1/early S‐phase donor nuclei and MII oocytes. In nuclear transfer embryos, DNA rerelication was likely to have occurred because ...
Tópico(s): Pluripotent Stem Cells Research
1995 - Wiley | Molecular Reproduction and Development
Rafael A. Fissore, Clara Pinto‐Correia, James M. Robl,
Bovine eggs exhibit repetitive rises in intracellular calcium concentration ([Ca2+]i) in response to fertilization. The signaling pathways and Ca2 release mechanisms involved in their generation are not well characterized. This study examined the presence of a GTP-binding protein (G-protein) signaling pathway as well as the role of inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R)-mediated Ca2+ release and ryanodine receptor (RyR)-mediated Ca2+ release, the two Ca2+ receptors/channels most often ...
Tópico(s): Aquaculture Nutrition and Growth
1995 - Oxford University Press | Biology of Reproduction
Clara Pinto‐Correia, Elaine G. Goldstein, Vann Bennett, J.Sabina Sobel,
The mouse oocyte expresses a polypeptide of Mr 120,000 that cross-reacts with an antibody to the brain membrane skeletal protein adducin. Immunofluorescence localization showed a bright chromosomal staining reaction in metaphase I and metaphase II oocytes. Following in vitro fertilization the maternal chromosomes lost their immunoreactivity during pronuclear development. The fertilizing sperm chromatin and male pronucleus did not show any detectable staining reaction. Bright chromosomal fluorescence ...
Tópico(s): Genomics and Chromatin Dynamics
1991 - Elsevier BV | Developmental Biology
Filipe Costa e Silva, Alexandra Correia, Clara Pinto, Jorge S. David, Virginia Hernández‐Santana, Teresa S. David,
Cork is a high value periodical forest product which ensures the economic, social and ecological sustainability of cork oak woodlands. Abiotic and biotic stresses lead to tree decline which is endangering the productivity and sustainability of these ecosystems. It is therefore critical to find and implement management practices that minimize the impact of these stresses. The current study was conducted in a certified evergreen cork oak woodland of central Portugal under Mediterranean climate. The ...
Tópico(s): Tree-ring climate responses
2021 - Elsevier BV | Forest Ecology and Management
... Ovary ofEve: Egg and Sperm and Preformation. By Clara Pinto-Correia . With a forward by Stephen Jay Gould. Chicago: ... culture-bound the human sciences were (and are) . Clara Pinto-Correia, a Portuguese developmental biologist and post-doctoral student ...
Tópico(s): Reproductive Health and Technologies
1998 - Johns Hopkins University Press | Perspectives in biology and medicine
... of Eve: egg and sperm and preformation (1997). Clara Pinto Correia. Chicago: Chicago University Press, 396 pp. R.V. ...
Tópico(s): Assisted Reproductive Technology and Twin Pregnancy
1998 - Wiley | BioEssays
... Ovary of Eve: Egg and Sperm and Preformation. Clara Pinto-Correia John FarleyJohn Farley Search for more articles by ...
Tópico(s): Fish biology, ecology, and behavior
1999 - University of Chicago Press | Isis
... Ovary of Eve: Egg and Sperm and Preformation. Clara Pinto-Correia Francisco J. AyalaFrancisco J. Ayala Search for more ...
Tópico(s): Animal Genetics and Reproduction
1999 - University of Chicago Press | The Quarterly Review of Biology
... Age of Reproductive Biotechnology. By Scott Gilbert and Clara Pinto-Correia; Foreword by Donna Haraway. New York: Columbia University ...
Tópico(s): Reproductive Health and Technologies
2020 - University of Chicago Press | The Quarterly Review of Biology
Clara Pinto‐Correia, João Lourenço Monteiro,
In 1756, while he was regent of the Faculté de Médecine in Paris, Charles-Augustin Vandermonde published his Essai sur la Manière de Perfectionner l'Espèce Humaine. This treatise was situated within the French-led medical movement of meliorism, meant to increase public health by boosting the medical arrangement of marriages from all strata of society. What made Vandermonde different from his colleagues is that he was not just looking for a way to improve the health of society: he was also proposing ...
Tópico(s): History of Science and Medicine
2013 - Elsevier BV | Endeavour
... of Eve: Egg and Sperm and Preformation, by Clara Pinto-Correia." Canadian Journal of History, 33(3), pp. 501– ...
Tópico(s): Reproductive Health and Technologies
1998 - University of Toronto Press | Journal of History
... of Eve: egg and sperm and preformation (1997). Clara Pinto Correia. Chicago: Chicago University Press, 396 pp. R.V. ...
Tópico(s): Assisted Reproductive Technology and Twin Pregnancy
1998 - Wiley | BioEssays
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Tópico(s): Cultural, Media, and Literary Studies
2006 - | Revista do Centro de Estudos Portugueses
Tópico(s): Historical Education and Society
1993 - American Association of Teachers of Spanish and Portuguese | Hispania
Tópico(s): Reproductive Health and Technologies
2018 - SAGE Publishing | Feminism & Psychology
... Egg and Sperm and Preformation Virginia P. Dawson Clara Pinto-Correia. The Ovary of Eve: Egg and Sperm and ... 29.95. In this book, biologist and novelist Clara Pinto-Correia focuses on the history of preformation, an early ...
Tópico(s): Reproductive Health and Technologies
1999 - Johns Hopkins University Press | Bulletin of the history of medicine
H. Pinto, J. Correia, Russell Binions, Clara Piccirillo, Ivan P. Parkin, V. Teixeira,
A numerical model was developed which enables the calculation of the optical constants (refractive index, n and extinction coefficient, k) of thermochromic coatings based in undoped and doped vanadium dioxide thin coatings deposited on glass for use as an intelligent window - a window that can change the optical properties in response to the temperature. From experimental results it can be seen that the vanadium dioxide coating prepared by Atmospheric Chemical Vapour Deposition shows a switching efficiency ...
Tópico(s): Transition Metal Oxide Nanomaterials
2008 - Trans Tech Publications | Materials science forum
... Online publication date: 1-May-2023. Melo X, Pinto R, Angarten V, Coimbra M, Correia D, Roque M, Reis J, Santos V, Fernhall B and Santa‐Clara H (2021) Training responsiveness of cardiorespiratory fitness and ...
Tópico(s): Cardiac Health and Mental Health
2012 - Lippincott Williams & Wilkins | Circulation
Bárbara Correia, Marta Pintó‐Marijuan, Lucinda Neves, Ricard Brossa, Maria Celeste Dias, Armando Costa, Bruno B. Castro, Clara Araújo, Conceição Santos, M. M. Chaves, Glória Pinto,
Eucalyptus plantations are among the most productive forest stands in Portugal and Spain, being mostly used for pulp production and, more recently, as an energy crop. However, the region's Mediterranean climate, with characteristic severe summer drought, negatively affects eucalypt growth and increases mortality. Although the physiological response to water shortage is well characterized for this species, evidence about the plants' recovery ability remains scarce. In order to assess the physiological ...
Tópico(s): Plant Water Relations and Carbon Dynamics
2013 - Wiley | Physiologia Plantarum
Amy S. Paller, Carsten Flohr, Lawrence F. Eichenfield, Alan D. Irvine, Jamie Weisman, Jennifer Soung, Ana Pinto Correia, Chitra R. Natalie, Claudia Rodriguez Capriles, Evangeline Pierce, Sarah A. Reifeis, Renata Gontijo Lima, Clara Armengol Tubau, Vivian Laquer, Stephan Weidinger,
Atopic dermatitis (AD) is a chronic inflammatory skin disorder with limited treatment options for adolescents with moderate-to-severe disease. Lebrikizumab, a monoclonal antibody targeting interleukin (IL)-13, demonstrated clinical benefit in previous Phase 3 trials: ADvocate1 (NCT04146363), ADvocate2 (NCT04178967), and ADhere (NCT04250337). We report 52-week safety and efficacy outcomes from ADore (NCT04250350), a Phase 3, open-label study of lebrikizumab in adolescent patients with moderate-to-severe ...
Tópico(s): Allergic Rhinitis and Sensitization
2023 - Adis, Springer Healthcare | Dermatology and Therapy
... The Sad, Strange Tale of the Dodo. By Clara Pinto‐Correia. Copernicus Books. New York: Springer‐Verlag. $27.50. ...
Tópico(s): Fish biology, ecology, and behavior
2004 - University of Chicago Press | The Quarterly Review of Biology
... Ovary of Eve: Egg and Sperm and Preformation. Clara Pinto-Correia.Philip K. WilsonPhilip K. WilsonPDFPDF PLUS Add to ...
Tópico(s): Reproductive Biology and Fertility
1998 - Truman State University | Sixteenth Century Journal
... Ovary ofEve: Egg and Sperm and Preformation. By Clara Pinto-Correia . With a forward by Stephen Jay Gould. Chicago: ...
Tópico(s): Philosophy and History of Science
1998 - Johns Hopkins University Press | Perspectives in biology and medicine