
Edson Luiz Paes Camandaroba, Clarissa M. Pinheiro Lima, Sônia Gumes Andrade,
Oral transmission of Trypanosoma cruzi has been suspected when epidemic episodes of acute infection were observed in areas devoid of domiciled insect vectors. Considering that the distribution of T. cruzi biodemes differs in sylvatic and domestic cycles, results of studies on biodemes can be of interest regarding oral transmission. The infectivity of T. cruzi strains of different biodemes was tested in mice subjected to infection by the digestive route (gavage). Swiss mice were infected either with ...
Tópico(s): Helminth infection and control
2002 - UNIVERSIDADE DE SÃO PAULO | Revista do Instituto de Medicina Tropical de São Paulo
Anderson S. Pinheiro, Clarissa Eibl, Zeynep Ekman-Vural, Robert Schwarzenbacher, Wolfgang Peti,
The initial line of defense against infection is sustained by the innate immune system. Together, membrane-bound Toll-like receptors and cytosolic nucleotide-binding domain and leucine-rich repeat-containing receptors (NLR) play key roles in the innate immune response by detecting bacterial and viral invaders as well as endogenous stress signals. NLRs are multi-domain proteins with varying N-terminal effector domains that are responsible for regulating downstream signaling events. Here, we report ...
Tópico(s): Immune Response and Inflammation
2011 - Elsevier BV | Journal of Molecular Biology

Ana Laura Sica Cruzeiro, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Ricardo Tavares Pinheiro, Clarissa Lisbôa Arla da Rocha, Bernardo Lessa Horta,
O objetivo deste estudo foi avaliar os fatores associados ao número de parceiros sexuais, no último ano, e ao uso de preservativo nas últimas três relações sexuais, entre jovens de quinze e dezoito anos de idade. Trata-se de um estudo transversal com 960 adolescentes. Foram consideradas duas variáveis dicotomizadas como indicativas de comportamentos sexuais de risco: dois ou mais parceiros sexuais nos últimos doze meses e uso ocasional de camisinha nas três últimas relações. Foi investigada a associação ...
Tópico(s): Sex work and related issues
2010 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva

Maria Lúcia Ferreira, Sérgio Pinheiro, Clarissa C. Perrone, Paulo R. R. Costa, Vı́tor F. Ferreira,
The carbohydrate derivatives 1–5 were evaluated as chiral auxiliaries in the Diels–Alder reaction of its acrylate derivatives 6a–e with cyclopentadiene promoted by Lewis acids. Although excellent endo:exo ratios (98:2) were obtained in many cases, the π-facial selectivities were from low to moderate (up to 60% d.e.). An effect of non-coordinating solvents reversing the stereoselectivities of adducts obtained from acrylates 6a,b was also found.
Tópico(s): Synthetic Organic Chemistry Methods
1998 - Elsevier BV | Tetrahedron Asymmetry

Uirá Souto Melo, Lúcia Inês Macedo‐Souza, Thalita Figueiredo, Alysson R. Muotri, Joseph G. Gleeson, Gabriela Coux, Pablo Armas, Nora B. Calcaterra, João Paulo Kitajima, Simone Amorim, Thiago Rosa Olávio, Karina Griesi‐Oliveira, Giuliana Castello Coatti, Clarissa Ribeiro Reily Rocha, Marinalva Martins-Pinheiro, Carlos Frederico Martins Menck, Maha S. Zaki, Fernando Kok, Mayana Zatz, Silvana Santos,
SPOAN syndrome is a neurodegenerative disorder mainly characterized by spastic paraplegia, optic atrophy and neuropathy (SPOAN). Affected patients are wheelchair bound after 15 years old, with progressive joint contractures and spine deformities. SPOAN patients also have sub normal vision secondary to apparently non-progressive congenital optic atrophy. A potential causative gene was mapped at 11q13 ten years ago. Here we performed next-generation sequencing in SPOAN-derived samples. While whole- ...
Tópico(s): Neurogenetic and Muscular Disorders Research
2015 - Oxford University Press | Human Molecular Genetics

Michele S. Pinto, Ana Clarissa dos Santos Pires, Helena Maria Pinheiro Sant’Ana, Nilda de Fátima Ferreira Soares, Antônio Fernandes de Carvalho,
As shelf life of pasteurized milk is relatively short the application of microfiltration was investigated as a way to increase milk shelf life. Raw milk was microfiltered and stored in bottles or pasteurized and stored in packages made from one of three different low density polyethylene (LDPE) multilayer films or a LDPE monolayer film. The results proved the efficiency of the 0.8 μm-microfiltration process in increasing shelf life of milk to at least 30 d with a reduction of the total microorganism ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2014 - Elsevier BV | Food Packaging and Shelf Life

Silvia Bueno Garofallo, Daniel Pinheiro Machado, Clarissa Garcia Rodrigues, Odemir Bordim, Renato A. K. Kalil, Vera Lúcia Portal,
Background: The applicability of international risk scores in heart surgery (HS) is not well defined in centers outside of North America and Europe. Objective: To evaluate the capacity of the Parsonnet Bernstein 2000 (BP) and EuroSCORE (ES) in predicting in-hospital mortality (IHM) in patients undergoing HS at a reference hospital in Brazil and to identify risk predictors (RP).Methods: Retrospective cohort study of 1,065 patients, with 60.3% patients underwent coronary artery bypass grafting (CABG), 32. ...
Tópico(s): Infective Endocarditis Diagnosis and Management
2014 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia

Aline Santos Monte, Bruna Stefânia Ferreira Mello, V. Borella, Tatiane da Silva Araújo, Francisco Eliclécio Rodrigues da Silva, Francisca Cléa Florenço de Sousa, Antônio Carlos Pinheiro de Oliveira, Clarissa Severino Gama, Mary V. Seeman, Silvânia Maria Mendes Vasconcelos, David Freitas de Lucena, Danielle S. Macêdo,
Schizophrenia is considered to be a developmental disorder with distinctive sex differences. Aiming to simulate the vulnerability of the third trimester of human pregnancy to the developmental course of schizophrenia, an animal model was developed, using neonatal poly(I:C) as a first-hit, and peripubertal stress as a second-hit, i.e. a two-hit model. Since, to date, there have been no references to sex differences in the two-hit model, our study sought to determine sex influences on the development ...
Tópico(s): Neuroendocrine regulation and behavior
2017 - Elsevier BV | Behavioural Brain Research

Lia Silveira Adriano, Helena Alves de Carvalho Sampaio, Soraia Pinheiro Machado Arruda, Clarissa Lima de Melo Portela, Maria Luísa Pereira de Melo, Antônio Augusto Ferreira Carioca, Nádia Tavares Soares,
Abstract The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising, an increase that may be associated with changes in lifestyle such as unhealthy dietary patterns. Although advanced age is a risk factor for NAFLD, no studies reporting this association in the elderly population were found. In the present study, the association between dietary patterns and NAFLD in the elderly was assessed. A study including 229 older adults was conducted. NAFLD diagnosis was defined as individuals whose ...
Tópico(s): Diet, Metabolism, and Disease
2016 - Cambridge University Press | British Journal Of Nutrition

Priscila Alves Medeiros de Sousa, Mário Vaisman, João Régis Ivar Carneiro, Lorena Guimarães, Heloisa Maria Pereira Freitas, Maria Fernanda Castellar Pinheiro, Sally Liechocki, Clarissa Menezes Maya Monteiro, Patrícia de Fátima dos Santos Teixeira,
To evaluate the prevalence of goiter and nodular disease in patients with class III obesity, and to correlate results with serum leptin levels and insulin resistance (IR) parameters.A cross-sectional study was performed to assess thyroid ultrasound (US) patterns, HOMA-IR, serum leptin, and TSH levels in obese patients and controls.Thyroid volume was positively correlated with body mass index (BMI) (r = 0.240, p = 0.039) and with HOMA-IR (r = 0.329; p < 0.01). Thyroid US patterns were similar between groups. ...
Tópico(s): Sexual Differentiation and Disorders
2013 - Editora da Universidade de São Paulo | Arquivos Brasileiros de Endocrinologia & Metabologia
Anderson S. Pinheiro, Martina Proell, Clarissa Eibl, Rebecca Page, Robert Schwarzenbacher, Wolfgang Peti,
The innate immune system provides an initial line of defense against infection. Nucleotide-binding domain- and leucine-rich repeat-containing protein (NLR or (NOD-like)) receptors play a critical role in the innate immune response by surveying the cytoplasm for traces of intracellular invaders and endogenous stress signals. NLRs themselves are multi-domain proteins. Their N-terminal effector domains (typically a pyrin or caspase activation and recruitment domain) are responsible for driving downstream ...
Tópico(s): interferon and immune responses
2010 - Elsevier BV | Journal of Biological Chemistry

Cézar Arthur Tavares Pinheiro, Luciano Dias de Mattos Souza, Janaína Vieira dos Santos Motta, Evelin Franco Kelbert, Clarissa de Souza Ribeiro Martins, Marília Silva de Souza, Karen Amaral Tavares Pinheiro, Fábio Monteiro da Cunha Coelho, Ricardo Tavares Pinheiro,
There is an increasing number of older patients with human immunodeficiency virus infection due to the success of antiretroviral therapy, the improved prognosis and life expectancy of patients, and the higher number of new infections among older individuals. The main objective of the present study was to compare the characteristics of older human immunodeficiency virus patients with those of younger patients.We conducted a cross-sectional study with human immunodeficiency virus-infected patients ...
Tópico(s): HIV Research and Treatment
2016 - Elsevier BV | The Brazilian Journal of Infectious Diseases

Clarissa Lisbôa Arla da Rocha, Bernardo Lessa Horta, Ricardo Tavares Pinheiro, Ana Laura Sica Cruzeiro, Suélen Henriques da Cruz,
This study aimed to assess the prevalence of contraceptive use by adolescents. A cross-sectional study was performed from March to September 2002 in a representative sample of adolescents 15 to 18 years of age in the urban area of Pelotas, Rio Grande do Sul State, Brazil. Multiple-stage sampling was used, and in the 448 census tracts located in the urban area, 90 were sampled and households were visited in each tract. Information was collected on sexual initiation and use of contraceptive methods. ...
Tópico(s): Global Maternal and Child Health
2007 - Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz | Cadernos de Saúde Pública

Clarissa Schreiner Miura, Ernani Miura, Alice Beatriz Mombach Pinheiro Machado, Marisa Chesky,
To determine the prevalence of congenital cytomegalovirus infection in newborn infants admitted to an intensive care unit in a public hospital in Porto Alegre.A cross-sectional study of 261 newborn infants born at a public hospital in the city of Porto Alegre in 2003 and admitted to the intensive care ward. Urine samples were collected within 7 days of birth and a polymerase chain reaction-PCR performed to test for cytomegalovirus DNA.The prevalence of congenital cytomegalovirus infection among ...
Tópico(s): Legionella and Acanthamoeba research
2006 - Elsevier BV | Jornal de Pediatria

Mariana Pinheiro Araújo, Nicola Innes, Clarissa Calil Bonifácio, Daniela Hesse, Isabel Cristina Olegário, Fausto Medeiros Mendes, Daniela Prócida Raggio,
Abstract Background Atraumatic Restorative Treatment (ART) and the Hall Technique (HT) are both minimally invasive, non-aerosol generating procedures (non-AGPs). They seem to have never been directly compared, nor has the HT been studied in a non-clinical setting. This study compared the HT and ART restorations placed in a school setting after 36 months. Methods Children (5–10 yo) who had a primary molar with a dentinal occluso-proximal, cavitated carious lesion were allocated to the ART (selective removal) ...
Tópico(s): Dental Health and Care Utilization
2020 - BioMed Central | BMC Oral Health

Isabela Azeredo Melca, Clarissa L. Rodrigues, Maria Antônia Serra-Pinheiro, Christos Pantelis, Dennis Velakoulis, Mauro V. Mendlowicz, Leonardo F. Fontenelle,
Delusional misidentification syndromes (DMS) have been rarely reported in patients with conditions other than schizophrenia-related disorders, diffuse brain disease (dementia) and focal neurological illness. In this report, we describe DMS (i.e. Capgras and Fregoli syndromes) in two patients with severe and treatment resistant obsessive–compulsive disorder (OCD), one with paranoid personality disorder (PPD) and the other with a pervasive developmental disorder (PDD) not otherwise specified. While our ...
Tópico(s): Face Recognition and Perception
2012 - Springer Science+Business Media | Psychiatric Quarterly

Marina Assis Pinheiro, Clarissa Maria Dubeux Lopes Barros, Roberta De Sousa Mélo,
This paper discusses the potential for accessing the intersubjective psychic dynamics that the use of oral diaries about everyday life can offer to Psychology, from an ideographic, cultural, and qualitative perspective. Based on the authors’ experience with this research activity mediated by instant messaging applications, we argue about the singularity produced by such a field of elaboration of meanings regarding the affective, ambiguous and potentially creative and authorial face of such enunciations. ...
Tópico(s): Identity, Memory, and Therapy
2022 - SAGE Publishing | Culture & Psychology

Ricardo Tavares Pinheiro, Jéssica Puchalski Trettim, Mariana Bonati de Matos, Karen Amaral Tavares Pinheiro, Ricardo Azevedo da Silva, Clarissa Ribeiro de Souza Martins, Gabriela Kurz da Cunha, Fernanda Teixeira Coelho, Janaína Vieira dos Santos Motta, Fábio Monteiro da Cunha Coelho, Gabriele Ghisleni, Fernanda Nedel, Ana Paula Ardais, Rafaelle Stark Stigger, Luciana de Ávila Quevedo, Luciano Dias de Mattos Souza,
Postpartum depression (PPD) affects a high number of women, often the first manifestation of a mood disorder that will occur later in life, bringing serious consequences for the patient and her offspring. Depression today is the leading cause of disability worldwide. The aim of this study was to evaluate the effectiveness of a preventive cognitive behavioral therapy (CBT) for PPD.
Tópico(s): Attachment and Relationship Dynamics
2021 - Elsevier BV | Journal of Affective Disorders
Clarissa Eibl, Simina Grigoriu, Manuel Hessenberger, Julia Wenger, Sandra Puehringer, Anderson S. Pinheiro, Roland N. Wagner, Martina Proell, John C. Reed, Rebecca Page, Kay Diederichs, Wolfgang Peti,
NLRP4 is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family of cytosolic receptors and a member of an inflammation signaling cascade. Here, we present the crystal structure of the NLRP4 pyrin domain (PYD) at 2.3 Å resolution. The NLRP4 PYD is a member of the death domain (DD) superfamily and adopts a DD fold consisting of six α-helices tightly packed around a hydrophobic core, with a highly charged surface that is typical of PYDs. Importantly, however, we identified several ...
Tópico(s): interferon and immune responses
2012 - American Chemical Society | Biochemistry

Larissa Marques Santana, L Perin, Rosana Pinheiro Lunelli, José Francisco Secorun Inácio, Clarissa Garcia Rodrigues, Bruna Eibel, Sílvia Goldmeier,
Tópico(s): Hormonal and reproductive studies
2019 - Springer Science+Business Media | Current Hypertension Reports

Isabel Cristina Olegário, Anna Luisa de Brito Pacheco, Mariana Pinheiro Araújo, Nathalia de Miranda Ladewig, Clarissa Calil Bonifácio, José Carlos Pettorossi Imparato, Daniela Prócida Raggio,
The high costs of the worldwide recommended GICs might be a barrier for the implementation of ART. To overcome this problem, low cost GIC are used even though there is a lack of evidence for the survival rate of restorations.To evaluate the performance of low-cost GICs used on occlusal ART restorations after one year.A total of 150 primary molars in 150 children with occlusal caries lesions were selected in 4-8 year-old children. The patients were randomly allocated in three groups: G1-GC Gold Label ...
Tópico(s): Dental materials and restorations
2016 - Elsevier BV | Journal of Dentistry

Clarissa Helena Santana, Ayisa Rodrigues Oliveira, Daniel Oliveira dos Santos, Samantha Pinheiro Pimentel, Lucas dos Reis de Souza, Larissa Giannini Alves Moreira, Heloísia Maria Bressan Braz, Thaynara Parente de Carvalho, Carlos Eduardo Bastos Lopes, Jefferson Bruno Soares Oliveira, Nayara Ferreira de Paula, Marcelo Pires Nogueira de Carvalho, Bruna Farias Alves, Hilda Fátima Jesus Pena, Renato L. Santos,
Abstract Background Toxoplasmosis is a zoonotic disease that affects humans and warm‐blooded animals. This study describes an outbreak of toxoplasmosis in howler monkeys ( Alouatta sp.) and survival of capuchins ( Sapajus apella ), under the same environmental conditions. Methods Howler monkeys were submitted to post‐mortem examination. Tissue samples were processed to histopathology and immunohistochemistry to detect lesions and tachyzoites of Toxoplasma gondii . Tissue samples were also frozen and submitted ...
Tópico(s): Rabies epidemiology and control
2020 - Wiley | Journal of Medical Primatology

Clarissa Pessoa Fernandes Forte, Amanda Pinheiro Leitão Matos, Felipe Herbert Mendes, Camila Costa Dias, Antonio Ernando Carlos Ferreira, Tácio Pinheiro Bezerra, Fabrício Bitú Sousa, Paulo Goberlânio de Barros Silva,
Objective: We evaluated the influence of photobiomodulation therapy (PBMT) application during bone healing postexodontia in rats. Methods: We divided 84 male Wistar rats into a control group (CG), which received placebo treatment without PBMT, and a test group (TG), which was treated with PBMT. After exodontia, the animals were subjected to PBMT (TG) with an AsGaAI diode laser at 810 nm, 100 mW, 2 J, and 70 J/cm2 or placebo treatment (CG) every 72 h. After 1, 3, 7, 14, 21, and 28 days, the animals were ...
Tópico(s): Dental Implant Techniques and Outcomes
2020 - Mary Ann Liebert, Inc. | Photobiomodulation Photomedicine and Laser Surgery

Francisco de Assis Caldas Pereira, Clarissa Araújo Silva Gurgel, Eduardo Antônio Gonçalves Ramos, Manuela Torres Andion Vidal, Antônio Luiz Barbosa Pinheiro, Vladimir Jurišić, Caroline Brandi Schlaepfer Sales, Patrícia Ramos Cury, Jean Nunes dos Santos,
The aim of this study was to investigate the presence of mast cells in a series of odontogenic tumors. Forty-five cases of odontogenic tumors were investigated using immunohistochemistry for mast cell triptase, and differences between groups were statistically evaluated. Mast cells were present in 96% of odontogenic tumors. Mast cells present in solid ameloblastoma were observed in the tumor stroma surrounding more solid and follicular epithelial islands, with or without squamous metaplasia. The ...
Tópico(s): Vascular Malformations and Hemangiomas
2011 - SAGE Publishing | Tumor Biology

Vı́tor F. Ferreira, Sérgio Pinheiro, Clarissa C. Perrone, Paulo R. R. Costa,
Acrylates 3-O-acryloyl-4,5-di-O-benzoyl-1,2- O-isopropylidene-beta-D-fructopyranose (6) and 3-O-benzyl-5-O-acryloyl-1,2-O -isopropylidene-alpha-D-xylofuranose (8) were synthesized in few steps from carbohydrates to construct chiral dienophiles for asymmetric Diels-Alder reaction with cyclopentadiene under thermal and Et2AlCl-promoted conditions. Although from moderate to excellent endo/exo ratios were obtained, low p-facial diastereoselectivities were observed for the cycloadducts 3-O-[(1'R, 4'R)-bicyclo-[ ...
Tópico(s): Phytochemistry and Bioactive Compounds
2000 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society

Lucas Pinheiro Dias, José T.A. Oliveira, Lady Clarissa Brito da Rocha-Bezerra, Daniele O.B. Sousa, Helen Paula Silva da Costa, Nadine Monteiro Salgueiro Araújo, Ana Fontenele Urano Carvalho, Pedro MS Tabosa, Ana Cristina de Oliveira Monteiro‐Moreira, Marina Duarte Pinto Lobo, Frederico Bruno Mendes Batista Moreno, B.A.M. Rocha, José Luiz de Souza Lopes, Leila Maria Beltramini, Ilka M. Vasconcelos,
A trypsin inhibitor from Cassia leiandra seeds, named ClTI, was purified, characterized, and its insecticidal activity against Aedes aegypti evaluated. ClTI was purified by DEAE-Cellulose and trypsin-Sepharose 4B chromatography, with a 15.5-fold purification and 2.4% yield. ClTI is composed of a 19,484 Da polypeptide chain as revealed by mass spectrometry, it is not a glycoprotein, its amino acid sequence is similar to other Kunitz-type inhibitors, and it comprises 35% β-sheets, 14% β-turns, and ...
Tópico(s): Insect Pest Control Strategies
2017 - Elsevier BV | Process Biochemistry

Dian Carlos Pinheiro Rosa, Carlos Rodrigo Brocardo, Clarissa Rosa, Arlison Bezerra Castro, Darren Norris, Rodrigo F. Fadini,
ABSTRACT Neotropical medium and large-bodied mammals are key elements in forest ecosystems, and protected areas are essential for their conservation. In Brazil, sustainable use protected areas (SU-PAs) allow both the conservation of biodiversity and the sustainable use of natural resources, especially in the Amazon region. However, SU-PAs usually suffer both internal and external pressures, and may be subject to variable degrees of defaunation. We sampled mammals using camera traps in two areas with ...
Tópico(s): Primate Behavior and Ecology
2021 - INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA | Acta Amazonica

Clarissa Schreiner Miura, Ernani Miura, Alice Beatriz Mombach Pinheiro Machado, Marisa Cheskya,
OBJETIVO: Determinar a prevalência da infecção congênita por citomegalovírus em recém-nascidos internados na unidade de terapia intensiva neonatal de um hospital público de Porto Alegre. METODOS: Estudo transversal, incluindo 261 recém-nascidos que nasceram em um hospital público da cidade de Porto Alegre no ano de 2003 e foram internados na unidade de terapia intensiva neonatal. Foi coletada amostra de urina nos primeiros 7 dias de vida e realizado o teste de reação em cadeia da polimerase para ...
Tópico(s): Neonatal Health and Biochemistry
2006 - Elsevier BV | Jornal de Pediatria

Ana Paula Teixeira Monteiro, Carla S. Pinheiro, Tatiana Luna-Gomes, Liliane R. Alves, Clarissa M. Maya‐Monteiro, Bárbara N. Porto, Christina Barja‐Fidalgo, Cláudia F. Benjamim, Marc Peters‐Golden, Christianne Bandeira‐Melo, Marcelo T. Bozza, Cláudio Canetti,
High concentrations of free heme found during hemolytic events or cell damage leads to inflammation, characterized by neutrophil recruitment and production of reactive oxygen species, through mechanisms not yet elucidated. In this study, we provide evidence that heme-induced neutrophilic inflammation depends on endogenous activity of the macrophage-derived lipid mediator leukotriene B(4) (LTB(4)). In vivo, heme-induced neutrophil recruitment into the peritoneal cavity of mice was attenuated by pretreatment ...
Tópico(s): Immune Cell Function and Interaction
2011 - American Association of Immunologists | The Journal of Immunology

Marilyn Aparecida Errobidarte de Matos, Clarissa Gomes Pinheiro de Sá,
RESUMOCom o fortalecimento da Rede Federal de Educação Profissional, Científica e Tecnológica, acentua-se também a preocupação com a formação de seus professores, na sua maioria bacharéis, sem formação pedagógica, atuantes no ensino médio (técnico integrado e subsequente), ensino superior (tecnólogo) e pós-graduação. O objetivo deste artigo é apresentar a concepção, desenvolvimento e aplicação de uma metodologia ativa na unidade curricular Dimensões da Ciência e Tecnologia no Contexto Escolar, no ...
Tópico(s): Education Pedagogy and Practices
2020 - Centro Universitário Internacional (UNINTER) | REVISTA INTERSABERES