By Christopher Thomas Labour Staff, By Our Parliamentary Correspondent, From Arthur Reed Air Correspondent, By a Staff Reporter, By Tim Devlin Education Correspondent, By Paul Routledge, By Christopher Wilkins Banking Correspondent, From Tim Jones Labour Staff, By Pat Healy Social Services Correspondent, From Our Labour Editor, From Hugh Clayton Agricultural Correspondent, By Our Horticultural Correspondent, By Our Local Government Correspondent, By Our Political Staff, By Christopher Warman Local Government Correspondent, From Christopher Walker, By Our Education Correspondent, From Patricia Clough, From Dan van der Vat, From Our Correspondent, From Michael Hornsby, From Fred Emery, From Eric Marsden, From Peter Strafford, From Mario Modiano, From Our Own Correspondent, From Michael Knipe, By Henry Stanhope Defence Correspondent, From Roger Berthoud, From Peter Hazelhurst, By John Woodcock Cricket Correspondent, From Norman Fox, From Neil Allen Athletics Correspondent, By Rex Bellamy Squash Rackets Correspondent, By Michael Coleman, By Michael Seely, Paul overy, John Percival, Irving Wardle, Ned Chaillet, Paul Griffiths, Max Harrison, Thomas Walker, Christine Long, PHS, Bernard Levin, A. N. THOMAS, , C M. S. WHITELAW, , KEITH GRAHAM, , FLETCHER., ROY STRONG, , D. WEDGWOOD., ROBERT J. CATON, , JOHN W. PARDOE, , C. S. BURDEN, , F. J. RUMP, , HUGH JENKINS, , EUGENE WASON, , GEORGE MALCOLM THOMSON, , MICHAEL HARBOTTLE, , THOMAS H. R. HARMSWORTH., Katie Stewart, By Geraldine Norman Sale Room Correspondent, From Our Parliamentary Correspondent, By Christopher Thomas, By David Blake, By Michael Baily Shipping Correspondent, By Maurice Corina Industrial Editor, By Clifford Webb, By Melvyn Westlake, By Roger Vielvoye, By John Brennan, By Desmond Ouigley, By Margaret Walters, By Peter Hill Industrial Correspondent, Kenneth Owen, By Derek Harris, By Our Commercial Editor, By Our Industrial Editor, MONICA SINCLAIR, PAUL BAXTER, DEREK STANSBY, CAROL MICKLEBURGH, CHRISTINE KENOVAN, DEREK JONES, HELEN LOUDON, L. MULFORD, VIVIEN USHER, , J. B. BRANSBURY, , N. A. BILITCH, , CHARLES WARD, , ANTHONY SAUNDERS, , BY THE FINANCIAL EDITOR, Clifford Webb, John Earle, From Roger Vielvove, From Charles Harrison, By Richard Allen, By Victor Felstead, By Ronald Pullen, by Peter Hopkirk, by Edward Mortimer, by Henry Stanhope, P.H., by Penelope Turing, P.T.,
... Maynard v Osborne Before Mr Justice Griffiths.. Reviews: Claudio Array Festival Hall Lontano Ensemble Purcell Room, Park ...
1976 - Gale Group | TDA
T.R. Jeffry Evans, Emma Dean, L Rhoda Molife, Juanita Lopez, Malcolm Ranson, Fatima El-Khouly, Ishtiaq Husain Zubairi, Claudio Savulsky, Larisa Reyderman, Yan Jia, Lorna Sweeting, Alastair Greystoke, Jorge Barriuso, Rebecca Kristeleit,
This phase 1 study examined the safety, tolerability, pharmacokinetics and preliminary efficacy of eribulin-liposomal formulation (eribulin-LF) in patients with advanced solid tumours.
Tópico(s): Nanoparticle-Based Drug Delivery
2019 - Springer Nature | British Journal of Cancer
From Moshe Brilliant, , From Christopher Walker, , By Colin Hughes, By David Felton Labour Correspondent, From Trevor Fishlock, By Patricia Clough, From Nicholas Ashford., By David Hewson, Arts Correspondent, By David Felton, Labour Correspondent, By Rupert Morris, From Peter Davenport, By Philip Webster, Political Reporter, By Anthony Bevins Political Correspondent, By Clifford Longley, Religious Affairs Correspondent, From Richard Ford, , From Tim Jones, By Richard Evans Lobby Correspondent, By Clifford Webb, Motoring Correspondent, By Peter Evans, Home Affairs Correspondent, By David Nicholson-Lord, From Frank Johnson, , From Nicholas Ashford, From Christopher Thomas, From Richard Owen, , From John Carlin, Richard Wigg, From Jan Raath, From Roger Boyes, From John Best, From Rasit Gurdilek, From David Bonavia, , From Diana Geddes, From a Correspondent, From Richard Dowden, , From Diana Geddes, , By Caroline Moorehead, From Michael Binyon, By William Pike, By Charles Knevitt, Architecture Correspondent, From Ian Murray, From Our Own Correspondent, Dennis Hackett, John Percival, Noël Goodwin, John Russell Taylor, Paul Griffiths, Richard Morrison, Marcel Berlins, Libby Purves, by Suzy Menkes, PHS, by David Steel, John Carlin, Colin Hughes, Roger Scruton, Miles Kington, FRANCES D'SOUZA, TONY HALL, , D. T. ALLSOP, , W. M. SAUNDERS, T. S. McLEOD, , JAMES PILDITCH, , N. S. PRICE, , D. A. BUDGETT., D. J. McCARTHY, , R. L. ZNAJEK, , THOMAS ARMSTRONG, , By Pearce Wright, Science Editor, By Geraldine Norman, Sale Room Correspondent, PMF, Executive Editor Kenneth Fleet, By Judith Huntley, Commercial Property Correspondent, By David Smith, Economics Correspondent, By Ian Griffiths, By Patience Wheatcroft, By John Lawless, By Peter Wilson-Smith, Banking Correspondent, By Our Economics Correspondent, By David Young Energy Correspondent, Michael Prest, By Derek Pain and Pam Spooner, Richard Thomson, By Richard Sarson, Bill Johnstone Technology Correspondent, by Kevan Pearson, By John Lamb, By Rory Johnston, By David Legard, From Stuart Jones Football Correspondent, By Paul Newman, By David Hands, Rugby Correspondent, By Our Correspondent, By John Hennessy, By Marcus Williams, By Peter Ball, By Alan Gibson, By Richard Streeton, By Ivo Tennant, By John Woodcock, Cricket Correspondent, From John Roberson, Prean: rare talent, By Jerome Caminada, David Miller, By Pat Butcher, By a Correspondent, By Mandarin, By Brian Beel, Peter Dear, Peter Davalle, By Julian Haviland, Political Editor, Roger Boyes,
... Horszowski, Galleries A natural talent for symbolism, Concert Claudio Arrau. Arts and Entertainment: The Times Crossword Puzzle ...
1985 - Gale Group | TDA
Produção Nacional
Revisado por pares
Mitchell H. Rosner, Faeq Husain‐Syed, Thiago Reis, Claudio Ronco, Raymond Vanholder,
Uremic encephalopathy encompasses a wide range of central nervous system abnormalities associated with poor kidney function occurring with either progressive chronic kidney disease or acute kidney injury. The syndrome is likely caused by retention of uremic solutes, alterations in hormonal metabolism, changes in electrolyte and acid-base homeostasis, as well as changes in vascular reactivity, blood-brain barrier transport, and inflammation. There are no defining clinical, laboratory, or imaging ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2021 - Elsevier BV | Kidney International
Ian Key, Jonathan Northcroft, Kevin Dunn, Waldemar Januszczak, John Dugdale, Hala Jaber, Julia Llewellyn Smith, Maggie O'Farrell, Philip Green, Richard Brundle, Matthew Wall, Helena Frith Powell, Robin Egga, Nigel Botherway, Barbara Hall, Rev J Graham Smith, Kathleen Riley, David Mills, Peter Whittle, Helen Davies, Sally Brock, Rob Hughes, Jason Dawe, John Peter, Ross Noble, Professor Gideon Garter, Clarence Birdseye, Jonathan Miller, Jason Page, Andrew Longmore, Fred Beckett, Alexander Frater, Dr D Ian Calvert, Jane Mulkerrins, Susan d'Arcy, Gareth Walsh, Richard Thomas, Frank Whitford, Ivo Tennant, Reg Tripp, Frank Chapman's, Ferdinand Mount, David Gower, Kathryn Cooper, Sam Gilpin, Tim Ewington, Lucy Hughes-Hallett, David Smith, David Lovibond, Kenneth Wood, Roger Norman, Nick Pitt, Sarah Milstein, Jenny Morrison, Neil Wormald, Clive Davis, E P, Edward Hopper, Andrew Porter, Tony Allen-Mills, Simon Wilde, Alex Clarke, Tristram Hunt, Martin James, Tom Walker, Anthony Sattin, Bette Graham, Robert Winnett, Irwin Stelzer, Robert Hewison, Peter Wilson, Rosie Millard, Tom McEnaney, Lawrence Dallaglio, Neil Leighton, David Dougill, Dale DeGroff, Syed Rashid Husain, Christopher Hart, Matt Stevenson, Allen Esterson, Geoff Williams, David Hewson, Cally Law, David Bond, Sue Hyde, Hugh Canning, Alasdair Reid, Lewis Peake, Geraldine Hackett Education Correspondent, Margarette Driscoll, Jeremy Clarkson, Mike Pattenden, Edward Porter, David Cairns, Trevor Nelson, Nicola Smith, Stewart Lee, Michael Portillo, Richard Newton, Victoria Segal, Patricia Nicol, Anthony Peregrine, Sarah Dempster, Kelly Holmes, Dave Pollard, Kevin Jackson, Richard Fletcher, Lilian Pizzichini, Brian Rowe, Dr Barry Clayton, Bill Lewis, Adam Nathan, Andrew Porter Deputy Political Editor, Paul Bailey, Lizzie Enfield, Brendan Bourne, Mike Laws, Paul Ham, Stuart Wavell, Sarah-Kate Templeton, Roger Eglin, Paul Donovan, Peter Hounam, Mark Espiner, Pat Cash, Chris Barber, Chris Woodhead, Cosmo Landerson, Jasper Gerard, Derek Clements, Paul Driver, John Follain, Richard Brooks, Dr Alistair Sinclair, Julie Earle-Levine, Ian Hawkey, Sally Jones, Stuart Andrews, Peter Kemp, David Leppard, Shelley Von Strunckel, Paul Durman, Lisa Grainger, Mark Edwards, Heather Dixon, Rachel Bridge, Sarah Gracie, Trevor Hamley, Simon Periam, Paul Sexton, Donna H Pidgeon, Phil Baker, Christina Lamb, Krystian Zimerman, Lois Rogers, Sue Peakall, Raymond Keene, Mark Brownrigg Director-General, Mimi Spencer, David Cracknell, Cosmo Landesman, Nelly Sindayen, Zoe Brennan, Robbie Hudson, Diana Wright, Elizabeth Scott-Bawnann, Helen Hawkins, Dominic O'Connell, Barry Flatman, Nick Cain, Louise Armitstead, Edwina Currie, Michael Wright, Keith Cameron, Natalie Graham, D Wathen, Barry Now Combe, Andrew Baillie, Caroline Donald, Hugh McManners, Peter Hillary, Colin McDOWELL, Ian Critchley, David Walsh, Liat Joshi, G Doyle, Jack Grimston, Bryan Appleyard, Stephen Armstrong, John Elliott, Burlington Bertie, Michele Roberts, Victoria O'brien, Jonathan Leake Environment Editor, Geoff Carr, Richard Woods, Roland White, Roy Mather, Mohamed Farah, Shane Watson, Ali Allen, Andrew Frankel, Maurice Chittenden, Alex Fortune, Andrew Balding, Judith O'Reilly, Mark Franchetti, Richard Rae, David Doe, Jon Ungoed-Thomas, Dr Kevin Law, Ray Hutton, Sebastian Coe, John Crossland, Clare Francis, Ian Thomson, Dr David Green, Dipesh Gadher, Christina Lamb Kabul, John Waples, Hunter Davies, Levi Strauss, Jeremy Hart, A A Gill, John Exelby, Brian Glanville, Neville Burrows, Dr David Simcock, Bill Coltham, John Carey, David Horspool, Andrew Lycett, Nick Fielding, Stephen Pettitt, Jonathan Carr-Brown, Will Iredale, Jonathan Leake Science Editor, Willy Müller, Daisy Thomas, Justin Sparks, Sally Kinnes, Morris Marshall, Angus McCrone, Naomi Caine, Nigel Powell, David Wickers, Kevin Hackett, Daniel Emery, Graham Dunn, Brian Doogan, R B J T Allenby, John Aizlewood, Minette Marrin, Jeremy Lazell, Mark Hodson, Trevor McDonald, Joanne Robertson, Art Fry, Joe Lovejoy, Jonathan Futrell, Ian Caldwell, Graham Norwood, David Budworth, Rael Dornfest, Hugh Pearman, Andrew Davidson, Dan Cairns, Stewart Mitchell, David Smith Economics Editor, Rouzbeb Pirouz, Bob Dwyer, E Johnson, Matthew Goodman, David Robertson, India Knight, Katya Kabanova, Adrienna Connors, Simon Howard, Ed Hughes, Fiona Henderson, Barry Newcombe, Dominic Rushe, Richard Lewis, Percy Spencer, Karen Robinson,
... for the Tinkerman to plan his next move Claudio Ranieri should have plenty of options — and a ...
2004 - Gale Group | Sunday Times HA GDA
Aashish Sharma, José J. Zaragoza, Gianluca Villa, Leonardo Ribeiro, Renhua Lu, Marco Sartori, Elena Faggiana, Massimo de Cal, Grazia Maria Virzì, Valentina Corradi, Alessandra Brocca, Faeq Husain‐Syed, Alessandra Brendolan, Claudio Ronco,
Renal function reserve (RFR) describes the capacity of the kidney to increase glomerular filtration rate (GFR) in response to physiological or pathological stimuli. The scope of our study was to evaluate the optimal level of stimulation using different doses of protein load (PL) for a standard renal stress test (RST).18 young healthy individuals were given sessions of PL with 1 and 2 g/kg body weight. Endogenous creatinine clearance was calculated. Baseline GFR (bGFR) and stress GFR (sGFR) (post-PL) were ...
Tópico(s): Acute Kidney Injury Research
2016 - Dustri-Verlag | Clinical Nephrology
From LOUIS HEREN, From RICHARD WIGG, FROM OUR OWN CORRESPONDENT, From DAVID BONAVIA, Tony Dawe, From JOHN CLARE, By DAVID WOOD, By a Staff Reporter, From Our Correspondent, By Our Political Staff, By BRIAN MacARTHUR, By FRANK ROBERTS, By TONY ALDOUS, By CLIVE BORRELL, By ARTHUR REED, From PETER STRAFFORD, From EDWARD MORTIMER, FROM OUR CORRESPONDENT, From Our Own Correspondent, From PETER NICHOLS, From FRED EMERY, From MICHAEL HORNSBY, From MARIO MODIANO, From PIERRE COMPARET, From DAVID LEITCH, From MICHAEL KNIPE, From Our Latin America Correspondent, From STEWART HARRIS, From DAN VAN DER VAT, by John Percival, By William Mann, by John Higgins, By Leonard Buckley, By Alan Blyth, Max Harrison, Joan Chissell, Michael Leapman, David Wood, PHS, D. E. COOMBE, D. P. DYMOND, M. D. HOOPER, O. RACKHAM, R. M. ROBBINS, JOHN REDDAWAY, G. M. WILSON, R. GRAHAM PAGE, A. J. SAMBROOK, By Norman Fowler, Home Affairs Correspondent, J. ST. BODFAN GRUFFYDD, JOHN LOMAX, LEONARD GREGORY, JACK BERESFORD, By LEONARD AMEY, From Our Bridge Correspondent, By a Woman Farmer, Lieutenant-General Sir John Glubb, BY MICHAEL PHILLIPS, Racing Correspondent, By Our Racing Correspondent, By Our Newmarket Correspondent, By JIM SNOW, Northern Racing Correspondent, By BRIAN LEWIS, By ROY McKELVIE, By U. A. TITLEY, Rugby Correspondent, By GORDON ALLAN, By RICHARD STREETON, By GEOFFREY GREEN, Football Correspondent, By NORMAN FOX, GEOFFREY GREEN, By TOM FREEMAN, By GERALD SINSTADT, By NORMAN CREEK, From NEIL ALLEN, Boxing Correspondent, From JOHN BALLANTINE, By Our Rifle Shooting Correspondent, By REX BELLAMY, Squash Rackets Correspondent, From PETER RYDE, Golf Correspondent, By W. W. Boulton, By PEARCE WRIGHT, By GERALD ELY, By KENNETH OWEN, Technology Correspondent, By GILES SMITH, By CLIVE CALLOW, Our Political Staff, By TERRY BYLAND, From ANTHONY THOMAS US Economics Correspondent, MALCOLM BROWN, Edited by Robert Jones, Robert Jones, Ross Davies, Innis Macbeath, BY THE FINANCIAL EDITOR, From PHILIP JACOBSON, CLIFFORD WEBB, By MELVYN WESTLAKE, CHELMER, D. F. HUNT, C. P. MARKS, L. H. GRESHAM, Anthony Thomas, BERRY RITCHIE, GILLIAN GRAHAM, by Giorgio Borsa, Milan Correspondent, by Elisa Massai, by Claudio Risé, Industrial Correspondent., by Enrico Colombi, Stock Market Correspondent, by Camilla Cederna, by John H. McCaffery, by Myriam De Cesco,
... Maj-Gen V Street Military adviser to Kinh Husain, Castleton Knight Pioneer of news films, Obituary, Peake ...
1970 - Gale Group | TDA
Faeq Husain‐Syed, Claudio Ronco,
A recent observational study reports that after cardiac surgery, clinical outcomes differ significantly between patients with the same stage of acute kidney injury (AKI) depending on the diagnosis criteria used: urine output, serum creatinine or both. This finding emphasizes the limitations of current criteria for AKI risk stratification and diagnosis.
Tópico(s): Trauma, Hemostasis, Coagulopathy, Resuscitation
2018 - Nature Portfolio | Nature Reviews Nephrology
By Fred Emery Political Editor, By David Felton Labour Staff, By Hugh Noyes Parliamentary Correspondent, By Hugh Noyes Parliamentary Correspondent, , By Peter Evans Home Affairs Correspondent, By Nicholas Timmins, by Baron Phillips, From Michael Leapman, By David Blake Economics Editor, By George Clark Political Correspondent, By Our Labour Staff, By Our Political Staff, By David Felton Labour Reporter, By Lucy Hodges, By John Young Planning Reporter, From Christopher Thomas, By Geraldine Norman Sale Room Correspondent, By Our Political Editor, From a Staff Reporter, By Peter Hennessy, By Diana Geddes Education Correspondent, By Our Music Reporter, By Pat Healy Social Services Correspondent, By Our Education Correspondent, By David Nicholson Lord, By Christopher Warman Local Government Correspondent, By a Staff Reporter, By Michael Baily Transport Correspondent, From Our Correspondent, From Ronald Kershaw, By Hugh Clayton, By Donald Macintyre Labour Reporter, From Harry Debelius, From David Bonavia, From Tewfik Mishlawi, From Christopher Walker, From Michael Hornsby, By Our Diplomatic Staff, From John Best, From Stephen Taylor, From Patricia Clough, By Martin Huckerby Music Reporter, From Frederick Bonnart, From Dessa Trevisan, From Peter Hazelhurst, From a Special Correspondent, From Patrick Brogan, From Charles Hargrove, From Our Own Correspondent, From David Wood, From Trevor Fishlock, From Ray Kennedy, Charles McKean Architectural Correspondent, Shona Crawford Poole, By Norman Fox Football Correspondent, By Gordon Allan, By Rex Bellamy Squash Rackets Correspondent, By Clive White, By Sydney Friskin, By Richard Streeton, By Roy Mckelvie, By Michael Seely, By John Wilcockson, From John Hennessy Golf Correspondent, By Jim Railton, Michael Ratcliffe, Norman Fox, Jan Stephens, Robert Nye, Philip Howard, Paul Barker, Andrew Sinclair, Richard Williams, John Percival, Paul Griffiths, Irving Wardle, Hilary Finch, Martin Huckerby, Bernard Levin, Geraldine Norman Saleroom Correspondent, Alan Hamilton, Ronald Butt, P. T. BAUER, , HILARY BAGSHAWE, , ROSALIND KING, , INDRA KULATILAKE, , HORIA GEORGESCIL, , ANTHONY BRYER, , COLEMAN MORRISON, , ALEC DICKSON, , CHARLES BROOK, , GEOFFREY N. SHAW, , JAMES CUMMINS, , TONY SMYTHE, , P. A. BAYLISS, , MICHAEL PERRY, , CLAUDIO ABBADO, , DANIEL BARENBOIM, , COLIN DAVIS, , JAMES GALWAY, , BERNARD HAITINK, , YEHUDI MENUHIN, , PETER PEARS, , MAURIZIO POLLINI, , GEORG SOLTI, , ISAAC STERN, , PINCHAS ZUKERMAN, , CORRELLI BARNETT, , EDWIN KERR, , ROBIN BRYER, , From Philip Howard, By Harry Golombek Chess Correspondent, From Pearce Wright Science Editor, By Ronald Pullen, By Peter Hill Industrial Editor, By Paul Routledge Labour Editor, From Peter Norman, By Edward Townsend, By Margareta Pagano, By Our Economics Staff, Derek Harris, By Michael Baily, By Our Industrial Staff, By John Huxley, By Kenneth Owen Technology Editor, STUART EBOR, , WILLIAM BECKETT, , R. SABRY-GRANT, , ERIC FAULKNER, , PHILIP GOLDENBERG, , BY THE FINANCIAL EDITOR, Ross Davies, Melvyn Westlake, Margaret Stone, By Our Financial Staff, Michael Prest Mining Correspondent, Edited by Peter Davalle,
... Divorce controversy splits ruling party in Spain, King Husain reaffirms tough line at No 10, New Thatcher ...
1981 - Gale Group | TDA
Faeq Husain‐Syed, Horst‐Walter Birk, Claudio Ronco, Tanja Schörmann, Khodr Tello, Manuel J. Richter, Jochen Wilhelm, Natascha Sommer, Ewout W. Steyerberg, Pascal Bauer, Hans‐Dieter Walmrath, Werner Seeger, Peter A. McCullough, Henning Gall, Hossein A. Ghofrani,
Background Persistent congestion with deteriorating renal function is an important cause of adverse outcomes in heart failure. We aimed to characterize new approaches to evaluate renal congestion using Doppler ultrasonography. Methods and Results We enrolled 205 patients with suspected or prediagnosed pulmonary hypertension ( PH ) undergoing right heart catheterization. Patients underwent renal Doppler ultrasonography and assessment of invasive cardiopulmonary hemodynamics, echocardiography, renal function, ...
Tópico(s): Blood Pressure and Hypertension Studies
2019 - Wiley | Journal of the American Heart Association
Faeq Husain‐Syed, Mitchell H. Rosner, Claudio Ronco,
Abstract Acute kidney injury (AKI) is a common complication in critically ill patients and it is associated with increased morbidity and mortality. Epidemiological and clinical data show that AKI is linked to a wide range of distant organ injuries, with the lungs, heart, liver, and intestines representing the most clinically relevant affected organs. This distant organ injury during AKI predisposes patients to progression to multiple organ dysfunction syndrome and ultimately, death. The strongest ...
Tópico(s): Renal function and acid-base balance
2019 - Wiley | Acta Physiologica
Faeq Husain‐Syed, Arthur S. Slutsky, Claudio Ronco,
Discoveries have emerged highlighting the complex nature of the interorgan cross-talk between the kidney and the lung. Vascular rigidity, neurohormonal activation, tissue hypoxia, and abnormal immune cell signaling have been identified as common pathways leading to the development and progression of chronic kidney disease. However, our understanding of the causal relationships between lung injury and kidney injury is not precise. This review discusses a number of features and mechanisms of renal ...
Tópico(s): Renal function and acid-base balance
2016 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Claudio Ronco, Lakhmir S. Chawla, Faeq Husain‐Syed, John A. Kellum,
Sepsis and septic shock remain drivers for morbidity and mortality in critical illness. The clinical picture of patients presenting with these syndromes evolves rapidly and may be characterised by: (a) microbial host invasion, (b) establishment of an infection focus, (c) opsonisation of bacterial products (e.g. lipopolysaccharide), (d) recognition of pathogens resulting in an immune response, (e) cellular and humoral effects of circulating pathogen and pathogen products, (f) immunodysregulation and endocrine ...
Tópico(s): Sepsis Diagnosis and Treatment
2023 - BioMed Central | Critical Care
Produção Nacional
Revisado por pares
Husain A. Lockhat, José Rogério A. Silva, Cláudio Nahum Alves, Thavendran Govender, Jerônimo Lameira, Glenn E. M. Maguire, Yasien Sayed, Hendrik G. Kruger,
In this work, have investigated the binding affinities of nine FDA-approved protease inhibitor drugs against a new HIV-1 subtype C mutated protease, I36T↑T. Without an X-ray crystal structure, homology modelling was used to generate a three-dimensional model of the protease. This and the inhibitor models were employed to generate the inhibitor/I36T↑T complexes, with the relative positions of the inhibitors being superimposed and aligned using the X-ray crystal structures of the inhibitors/HIV-1 ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2015 - Wiley | Chemical Biology & Drug Design
Faeq Husain‐Syed, Horst-Walter Birk, Jochen Wilhelm, Claudio Ronco, V. Marco Ranieri, Bianka Karle, Stefan Kuhnert, Khodr Tello, Matthias Hecker, Rory E. Morty, Susanne Herold, Oliver Kehl, Hans-Dieter Walmrath, Werner Seeger, István Vadász,
Coronavirus disease 2019 (COVID-19)-associated acute respiratory distress syndrome (ARDS) is associated with high mortality. Lung-protective ventilation is current standard of care in patients with ARDS, but it might lead to hypercapnia, which is independently associated with worse outcomes. Extracorporeal carbon dioxide removal (ECCO2R) has been proposed as an adjuvant therapy to avoid progression of clinical severity and limit further ventilator-induced lung injury but its use in COVID-19 has not ...
Tópico(s): Cardiac Arrest and Resuscitation
2020 - Frontiers Media | Frontiers in Medicine
Sara Samoni, Faeq Husain‐Syed, Gianluca Villa, Claudio Ronco,
The history of continuous renal replacement therapy (CRRT) is marked by technological advances linked to improvements in the knowledge of the mechanisms and kinetics of extracorporeal removal of solutes, and the pathophysiology of acute kidney injury (AKI) and other critical illnesses. In the present article, we review the main steps in the history of CRRT, from the discovery of continuous arteriovenous hemofiltration to its evolution into the current treatments and its early use in the treatment ...
Tópico(s): Organ Donation and Transplantation
2021 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Produção Nacional
Revisado por pares
Faeq Husain‐Syed, Thiago Reis, Kianoush Kashani, Claudio Ronco,
Recent advances have improved our understanding of the epidemiology and pathophysiology of acute kidney injury (AKI). So far, the Kidney Disease: Improving Global Outcome guidelines define and stratify kidney injury based on increases in serum creatinine level and/or decreases in urine output. Although the term AKI acknowledges the existence of cellular injury, its diagnosis is still only defined by the reduced excretory function of the kidney. New biomarkers that aid a better understanding of the ...
Tópico(s): Muscle and Compartmental Disorders
2022 - Elsevier BV | Practical Laboratory Medicine
Produção Nacional
Revisado por pares
Claudio Ronco, Thiago Reis, Faeq Husain‐Syed,
The outbreak of coronavirus disease 2019 (COVID-19) has rapidly evolved into a global pandemic. Most patients with COVID-19 have mild symptoms, but about 5% develop severe symptoms, which can include acute respiratory distress syndrome, septic shock, and multiple organ failure. Kidney involvement is frequent, with clinical presentation ranging from mild proteinuria to progressive acute kidney injury (AKI) necessitating renal replacement therapy (RRT). An understanding of the pathophysiology and mechanisms ...
Tópico(s): Thermal Regulation in Medicine
2020 - Elsevier BV | The Lancet Respiratory Medicine
Claudio Ronco, Zaccaria Ricci, Faeq Husain‐Syed,
Critically ill patients developing severe forms multiple organ dysfunction syndrome (MODS) may not be adequately supported by pharmacologic management. In these complex cases, a single form of extracorporeal organ support (ECOS) may be required, but multiple organ support therapy (MOST) is currently seen as a feasible approach. Severe renal dysfunction is a typical syndrome requiring renal replacement therapy (RRT) in the context of MODS. After more than a decade of RRT application in various intensive ...
Tópico(s): Respiratory Support and Mechanisms
2019 - Karger Publishers | Blood Purification
Gregorio Romero‐González, Joaquín Manrique, María Fernanda Slon-Roblero, Faeq Husain‐Syed, Rafael de la Espriella, Fiorenza Ferrari, Jordi Bover, Alberto Ortíz, Claudio Ronco,
Point-of-Care Ultrasonography (PoCUS) aims to include a fifth pillar (insonation) in the classical physical examination in order to obtain images to answer specific questions by the clinician at the patient's bedside, allowing rapid identification of structural or functional abnormalities, enabling more accurate volume assessment and supporting diagnosis, as well as guiding procedures. In recent years, PoCUS has started becoming a valuable tool in day-to-day clinical practice, adopted by healthcare ...
Tópico(s): Hemodynamic Monitoring and Therapy
2022 - Oxford University Press | Clinical Kidney Journal
Cláudio Silva, Douglas W. Reeve, Hadi Husain, Hamid R. Rabie, Kimberly A. Woodhouse,
A semi-empirical model that predicts permeate fluxes in high-shear microfiltration systems is proposed. The model assumes that non-diffusive transport phenomena are the main mechanisms for the back-transport of particles from the membrane surface to the bulk solution during filtration. It also considers the use of reverse filtration (back-flushing) to control and minimize concentration polarization and fouling. This model incorporates an equation for the transient flux based on a particle mass balance ...
Tópico(s): Dielectric materials and actuators
2000 - Elsevier BV | Journal of Membrane Science
Faeq Husain‐Syed, Peter A. McCullough, Horst‐Walter Birk, Matthias Renker, Alessandra Brocca, Werner Seeger, Claudio Ronco,
Over the past decade, science has greatly advanced our understanding of interdependent feedback mechanisms involving the heart, lung, and kidney. Organ injury is the consequence of maladaptive neurohormonal activation, oxidative stress, abnormal immune cell signaling, and a host of other mechanisms that precipitate adverse functional and structural changes. The presentation of interorgan crosstalk may include an acute, chronic, or acute on chronic timeframe. We review the current, state-of-the-art ...
Tópico(s): Cardiovascular Function and Risk Factors
2015 - Elsevier BV | Journal of the American College of Cardiology
Produção Nacional
Revisado por pares
Luigi Marzano, Faeq Husain‐Syed, Thiago Reis, Claudio Ronco, Monica Zanella,
Tópico(s): Cardiovascular, Neuropeptides, and Oxidative Stress Research
2022 - Springer Nature | Journal of Human Hypertension
David Claudio-González, Muhammad K. Husain, C.H. de Groot, Giuliano Bordignon, Thomas Fischbacher, Hans Fangohr,
We report the use of electron beam lithography and a bilayer lifto® process to fabricate magnetic Ni nanostructures with constriction widths in the range of 22 to 41 nm. The structures fabricated correspond to the nanobridge geometry. Reproducibility and control over the final nanostructure geometry were observed when using the fabrication process introduced, these two qualities are important in order to carry out a more systematic analysis of domain wall magnetoresistance (DWMR). On the other hand, ...
Tópico(s): ZnO doping and properties
2009 - Elsevier BV | Journal of Magnetism and Magnetic Materials
Faeq Husain‐Syed, Hermann‐Josef Gröne, Birgit Aßmus, Pascal Bauer, Henning Gall, Werner Seeger, Hossein A. Ghofrani, Claudio Ronco, Horst‐Walter Birk,
Abstract Venous congestion has emerged as an important cause of renal dysfunction in patients with cardiorenal syndrome. However, only limited progress has been made in differentiating this haemodynamic phenotype of renal dysfunction, because of a significant overlap with pre‐existing renal impairment due to long‐term hypertension, diabetes, and renovascular disease. We propose congestive nephropathy (CN) as this neglected clinical entity. CN is a potentially reversible subtype of renal dysfunction ...
Tópico(s): Dialysis and Renal Disease Management
2020 - Wiley | ESC Heart Failure
Luigi Marzano, Amir Kazory, Faeq Husain‐Syed, Claudio Ronco,
Abstract Complete resolution of hypertension (CRH) after adrenalectomy for primary aldosteronism is far from a certainty. Although several prognostic models have been proposed to predict outcome after adrenalectomy, studies have not clarified which of the available models can be used reliably in clinical practice. To identify, describe and appraise all prognostic models developed to predict CRH, and meta‐analyse their predictive performances. We searched MEDLINE, Embase and Web of Science for development ...
Tópico(s): Adrenal Hormones and Disorders
2023 - Wiley | Clinical Endocrinology
Claudio Infante, M. K. El Mously, R. Dayal, M. Husain, Saadat Anwar Siddiqi, P. Ganguly,
The effect of Pr substitution in suppressing Tc in LaCaBaCu3O7−d and Y0.8Ca0.2Ba2Cu3O 6+d has been studied. Infrared spectroscopy and a model based on ionic radii considerations were used to examine the location of Pr ions and the influence of Pr and Ca ions on hole localisation on chains and planes. For this purpose the series PrBa2−xCaxCu3O7−d was also studied. The main conclusions are that Pr ions play a role in suppressing Tc by exchange scattering, and to some extent by the hole filling mechanism ...
Tópico(s): Magnetic and transport properties of perovskites and related materials
1990 - Elsevier BV | Physica C Superconductivity
Sara Samoni, Gianluca Villa, Silvia De Rosa, Mauro Neri, Lorenzo Tofani, Faeq Husain‐Syed, Massimo de Cal, Federico Nalesso, Mario Meola, Claudio Ronco,
Tópico(s): Renal and Vascular Pathologies
2020 - Springer Science+Business Media | Journal of Nephrology
Faeq Husain‐Syed, Jochen Wilhelm, Shadi Kassoumeh, Horst-Walter Birk, Susanne Herold, István Vadász, Hans-Dieter Walmrath, John A. Kellum, Claudio Ronco, Werner Seeger,
Tópico(s): Muscle and Compartmental Disorders
2020 - Oxford University Press | Nephrology Dialysis Transplantation
Michael Joannidis, Lui G. Forni, Sebastian Klein, Patrick M. Honoré, Kianoush Kashani, Marlies Ostermann, John R. Prowle, Sean M. Bagshaw, Vincenzo Cantaluppi, Michaël Darmon, Xiaoqiang Ding, Valentin Fuhrmann, Eric A. J. Hoste, Faeq Husain‐Syed, Matthias Lubnow, Marco Maggiorini, Melanie Meersch, Patrick Murray, Zaccaria Ricci, Kai Singbartl, Thomas Staudinger, Tobias Welte, Claudio Ronco, John A. Kellum,
Multi-organ dysfunction in critical illness is common and frequently involves the lungs and kidneys, often requiring organ support such as invasive mechanical ventilation (IMV), renal replacement therapy (RRT) and/or extracorporeal membrane oxygenation (ECMO).
Tópico(s): Sepsis Diagnosis and Treatment
2019 - Springer Science+Business Media | Intensive Care Medicine