Bernardo Arriaza, Matthew R Doubrava, Vivien G. Standen, Herbert Haas,
... 101324Sandra Rebolledo, Philippe Béarez, Débora Zurro, Calogero M. Santoro, Claudio Latorre Big Fish or Small Fish? Differential Ichthyoarchaeological ... 10.1073/pnas.1212756109Pablo A. Marquet, Calogero M. Santoro, Claudio Latorre, Vivien G. Standen, Sebastián R. Abades, Marcelo ...
Tópico(s): Indigenous Health, Education, and Rights
2005 - University of Chicago Press | Current Anthropology
Francesco Costanzo, Mario P. Colombo, S Staempfli, Claudio Santoro, M. Marone, Ronald Frank, Hajo Delius, R. Cortese,
... author on: Oxford Academic PubMed Google Scholar Claudio Santoro, Claudio Santoro 3Istituto di Biologia Generale, University of TurinTurin, Italy ...
Tópico(s): Iron Metabolism and Disorders
1986 - Oxford University Press | Nucleic Acids Research
C. T. Smith, G. H. S. Bushnell, Henry F. Dobyns, Thomas McCorkle, John V. Murra,
... article:Mauricio Lima, Duncan A. Christie, M. Calogero Santoro, Claudio Latorre, Chris T. Bauch Coupled Socio-Environmental Changes ...
Tópico(s): Migration, Education, Indigenous Social Dynamics
1970 - University of Chicago Press | Current Anthropology
Claudio Zaccone, Anna Santoro, Claudio Cocozza, Roberto Terzano, William Shotyk, Teodoro Miano,
Tópico(s): Geology and Paleoclimatology Research
2008 - Elsevier BV | Geoderma
Giuseppe Maria Ettorre, Roberto Santoro, Claudio Puoti, Rosa Sciuto, L Carpanese, Mario Antonini, Giorgio Antonucci, C.L. Maini, L. Miglioresi, Giovanni Vennarecci,
... and intermediate stage HCC. Giuseppe Maria Ettorre Roberto Santoro Lucia Miglioresi Giovanni Vennarecci General Surgery and Transplantation Unit San Camillo Hospital Rome, Italy Claudio Puoti Department of Internal Medicine and Liver Unit ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2010 - Wolters Kluwer | Transplantation
Maria Grazia Franzosi, Eugenio Santoro, Claudio De Vita, Enrico Geraci, Antonio Lotto, Aldo P. Maggioni, Francesco Mauri, F Rovelli, Luigi Santoro, Luigi Tavazzi, Gianni Tognoni,
We conducted a 10-year follow-up of the 11 712 patients with acute myocardial infarction randomized in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto-1 study, the first large trial assessing thrombolytic therapy.Information on survival at 10 years was obtained for the 93% of all randomized patients through the census offices of their towns of residence. The difference in survival produced by streptokinase and sustained up to 1 year was still significant at 10 years (log-rank test, ...
Tópico(s): Cardiac Imaging and Diagnostics
1998 - Lippincott Williams & Wilkins | Circulation
Paola D’Errigo, Claudio Moretti, Fabrizio D’Ascenzo, Stefano Rosato, Fausto Biancari, Marco Barbanti, Francesco Santini, Marco Ranucci, Antonio Miceli, Corrado Tamburino, Francesco Onorati, Gennaro Santoro, Claudio Grossi, Danilo Fusco, Fulvia Seccareccia,
BackgroundThere are scarce data on outcomes after transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) in patients with renal failure.MethodsWe evaluated the impact of renal failure on outcomes after TAVI and SAVR and compared the results of these procedures in patients with chronic kidney disease stages 3b to 5 from the Observational Study of Effectiveness of AVR-TAVI Procedures for Severe Aortic Stenosis Treatment (OBSERVANT) study.ResultsChronic kidney disease ( ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2016 - Elsevier BV | The Annals of Thoracic Surgery
Karen A. Gelmon, Peter A. Fasching, Fergus J. Couch, Judith Balmañà, Suzette Delaloge, Sana Intidhar Labidi‐Galy, James Bennett, Susan McCutcheon, G.P. Walker, Joyce O’Shaughnessy, Constanta Timcheva, Antoaneta Tomova, Andrea Eisen, Karen A. Gelmon, Julie Lemieux, Fernando Bazán, Hugues Bourgeois, Camille Chakiba, Mohamad Chehimi, Florence Dalenc, Thibault De La Motte Rouge, Jean‐Sébastien Frénel, Anthony Gonçalvès, Anne Claire Hardy-Bessard, R. Lamy, Christelle Lévy, Alain Lortholary, Audrey Mailliez, Jacques Médioni, Anne Patsouris, Dominique Spaëth, Luís Teixeira, Isabelle Tennevet, Cristian Villanueva, Benoît You, Johannes Ettl, Bernd Gerber, Oliver Hoffmann, Tjoung‐Won Park‐Simon, Mattea Reinisch, Joke Tio, Pauline Wimberger, Katalin Boér, Alberto Ballestrero, Giampaolo Bianchini, Laura Biganzoli, Roberto Bordonaro, F. Cognetti, Michelino De Laurentiis, Sabino De Placido, Valentina Guarneri, Filippo Montemurro, Giuseppe Naso, Armando Santoro, Claudio Zamagni, Seung-Jin Kim, Seigo Nakamura, Yee Soo Chae, Eun Kyung Cho, Kim Jee Hyun, Seock‐Ah Im, Keun Seok Lee, Yeon Hee Park, Joohyuk Sohn, Tomasz Byrski, Tomasz Huzarski, Bożena Kukiełka-Budny, Zbigniew Nowecki, Renata Szoszkiewicz, R. Tarnawski, Viktoria Dvornichenko, Fedor Moiseenko, Guzel Mukhametshina, Elena Poddubskaya, Popova Ev, Anna Tarasova, Anna Vats, Bárbara Adamo, Raquel Andrés Conejero, A. Antón Torres, Judith Balmaña Gelpí, Nieves Díaz Fernández, Alejandro Falcón, Juan García, Isabel Lorenzo‐Lorenzo, Fernando Moreno Antón, Marta Santisteban, Agostina Stradella, Chiun‐Sheng Huang, Sercan Aksoy, Çağatay Arslan, Mehmet Artaç, Adnan Aydıner, Özgür Özyılkan, Emel Sezer, Anne Armstrong, Sophie Barrett, Annabel Borley, Zoe Kemp, Caroline O. Michie, Mukesh Mukesh, Timothy Perren, Angela Swampillai, Tammy Young,
BackgroundIn the phase III OlympiAD trial, olaparib significantly increased progression-free survival (PFS) compared with chemotherapy of physician's choice in patients with germline BRCA-mutated (gBRCAm), human epidermal growth factor 2 (HER2)-negative metastatic breast cancer (mBC). The phase IIIb LUCY trial assessed the clinical effectiveness of olaparib in similar patients, in a setting reflecting clinical practice.MethodsThis open-label, single-arm trial of olaparib (300 mg, twice daily) enrolled ...
Tópico(s): BRCA gene mutations in cancer
2021 - Elsevier BV | European Journal of Cancer
Johanna Diener, Arianna Baggiolini, Mattias Pernebrink, Damian Dalcher, Luigi Lerra, Phil F. Cheng, Sandra Varum, Jessica Häusel, Salome Stierli, Mathias Treier, Lorenz Studer, Konrad Basler, Mitchell P. Levesque, Reinhard Dummer, Raffaella Santoro, Claudio Cantù, Lukas Sommer,
Abstract Melanoma cells rely on developmental programs during tumor initiation and progression. Here we show that the embryonic stem cell (ESC) factor Sall4 is re-expressed in the Tyr::Nras Q61K ; Cdkn2a −/− melanoma model and that its expression is necessary for primary melanoma formation. Surprisingly, while Sall4 loss prevents tumor formation, it promotes micrometastases to distant organs in this melanoma-prone mouse model. Transcriptional profiling and in vitro assays using human melanoma cells demonstrate ...
Tópico(s): Epigenetics and DNA Methylation
2021 - Nature Portfolio | Nature Communications
Maria Conte, Morena Martucci, Giovanni Mosconi, Antonio Chiariello, Maria Cappuccilli, Valentina Totti, Aurelia Santoro, Claudio Franceschi, Stefano Salvioli,
Growth differentiation factor 15 (GDF15) is a stress molecule produced in response to mitochondrial, metabolic and inflammatory stress with a number of beneficial effects on metabolism. However, at the level of skeletal muscle it is still unclear whether GDF15 is beneficial or detrimental. The aim of the study was to analyse the levels of circulating GDF15 in people of different age, characterized by different level of physical activity and to seek for correlation with haematological parameters related ...
Tópico(s): Macrophage Migration Inhibitory Factor
2020 - Frontiers Media | Frontiers in Immunology
Annick P. M. van Soest, Gerben D. A. Hermes, Agnes A. M. Berendsen, Ondine van de Rest, Erwin G. Zoetendal, Susana Fuentes, Aurelia Santoro, Claudio Franceschi, C.P.G.M. de Groot, Willem M. de Vos,
Dietary modulation of the gastro-intestinal microbiota is a potential target in improving healthy ageing and age-related functional outcomes, including cognitive decline. We explored the association between diet, gastro-intestinal microbiota and cognition in Dutch healthy older adults of the 'New dietary strategies addressing the specific needs of the elderly population for healthy aging in Europe' (NU-AGE) study. The microbiota profile of 452 fecal samples from 226 subjects was determined using a ...
Tópico(s): Nutritional Studies and Diet
2020 - Multidisciplinary Digital Publishing Institute | Nutrients
Pol Grootswagers, Marco Mensink, Agnes A. M. Berendsen, Carolien P.J. Deen, Ido P. Kema, Stephan J. L. Bakker, Aurelia Santoro, Claudio Franceschi, Nathalie Meunier, Corinne Malpuech‐Brugère, Agata Białecka-Dębek, Katarzyna Rolf, Susan J. Fairweather‐Tait, Amy Jennings, Edith J. M. Feskens, C.P.G.M. de Groot,
Maintenance of high physical performance during aging might be supported by an adequate dietary intake of niacin, vitamins B-6 and B-12, and folate because these B vitamins are involved in multiple processes related to muscle functioning. However, not much is known about the association between dietary intake of these B vitamins and physical performance. The objectives of this study were to investigate the association between dietary intake of niacin, vitamins B-6 and B-12, and folate and physical ...
Tópico(s): Diet and metabolism studies
2020 - Elsevier BV | American Journal of Clinical Nutrition
Diego Montiel‐Rojas, Andréas Nilsson, Aurelia Santoro, Claudio Franceschi, Alberto Bazzocchi, Giuseppe Battista, C.P.G.M. de Groot, Edith J. M. Feskens, Agnes A. M. Berendsen, Barbara Pietruszka, Olga Januszko, Susan J. Fairweather‐Tait, Amy Jennings, Claudio Nicoletti, Fawzi Kadi,
Sarcopenia is characterised by a progressive loss of skeletal muscle mass and physical function as well as related metabolic disturbances. While fibre-rich diets can influence metabolic health outcomes, the impact on skeletal muscle mass and function is yet to be determined, and the moderating effects by physical activity (PA) need to be considered. The aim of the present study was to examine links between fibre intake, skeletal muscle mass and physical function in a cohort of older adults from the ...
Tópico(s): Obesity, Physical Activity, Diet
2020 - Multidisciplinary Digital Publishing Institute | Nutrients
Diego Montiel‐Rojas, Andréas Nilsson, Elodie Ponsot, Robert J. Brummer, Susan J. Fairweather‐Tait, Amy Jennings, C.P.G.M. de Groot, Agnes A. M. Berendsen, Barbara Pietruszka, Dawid Madej, Elodie Caumon, Nathalie Meunier, Corinne Malpuech‐Brugère, Giulia Guidarelli, Aurelia Santoro, Claudio Franceschi, Fawzi Kadi,
The present study aims to explore the potential influence of leucocyte telomere length (LTL) on both a single indicator and a composite construct of physical functioning in a large European population of elderly men and women across diverse geographical locations. A total of 1,221 adults (65-79 years) were recruited from five European countries within the framework of NU-AGE study. The physical functioning construct was based on the 36-item Short Form Health Survey. Handgrip strength was used as a ...
Tópico(s): Skin Protection and Aging
2018 - Frontiers Media | Frontiers in Physiology
Anna Marseglia, Weili Xu, Laura Fratiglioni, Cristina Fabbri, Agnes A. M. Berendsen, Agata Białecka-Dębek, Amy Jennings, Rachel Gillings, Nathalie Meunier, Elodie Caumon, Susan J. Fairweather‐Tait, Barbara Pietruszka, C.P.G.M. de Groot, Aurelia Santoro, Claudio Franceschi,
BACKGROUND―Findings from animal and epidemiological research support the potential neuroprotective benefits from healthy diets. However, to establish diet-neuroprotective causal relations, evidence from dietary intervention studies is needed. NU-AGE is the first multicenter intervention assessing whether a diet targeting health in aging can counteract the age-related physiological changes in different organs, including the brain. In this study, we specifically investigated the effects of NU-AGE' ...
Tópico(s): Biochemical effects in animals
2018 - Frontiers Media | Frontiers in Physiology
Mònica Maijó, Kamal Ivory, Sarah J. Clements, J. Dainty, Amy Jennings, Rachel Gillings, Susan J. Fairweather‐Tait, Massimo Gulisano, Aurelia Santoro, Claudio Franceschi, Simon R. Carding, Claudio Nicoletti,
Amongst the major features of ageing are chronic low grade inflammation and a decline in immune function. The Mediterranean diet (MD) is considered to be a valuable tool to improve health status, and although beneficial effects have been reported, to date, immunological outcomes have not been extensively studied. We aimed to test the hypothesis that one year of an tailored intervention based on the MD would improve innate immune responses in healthy elderly subjects (65–79 y) from the English cohort ( ...
Tópico(s): Nutrition, Genetics, and Disease
2018 - Frontiers Media | Frontiers in Physiology
Paola Calza, Giorgio Noè, Debora Fabbri, Valentina Santoro, Claudio Minero, Davide Vione, Claudio Medana,
The photochemical reactivity of three ionic liquids (1-ethylpyridinium tetrafluoroborate, 1-butyl-4-methylpyridinium tetrafluoroborate, and 1-(3-cyanopropyl)pyridinium chloride) was studied by combining laboratory experiments and photochemical modeling, to get insight into the possible behavior in surface-water environments. Among the studied compounds, phototransformation in sunlit surface waters could be an important attenuation pathway for 1-butyl-4-methylpyridinium tetrafluoroborate (BMPOTFB). ...
Tópico(s): Advanced oxidation water treatment
2017 - Elsevier BV | Water Research
Paola Calza, Debora Fabbri, Giorgio Noè, Valentina Santoro, Claudio Medana,
We studied some ionic liquids (ILs) belonging to the pyridinium class under photocatalytic treatment. In particularly, we analysed how the length of the alkyl chain, the kind of inorganic ion and the type of substituents could influence the disappearance rate, the mineralization extent, the acute toxicity and the transformation mechanism. For such, we selected some pyridinium derivatives with different alkyl chain but the same anion, namely tetrafluoroborate (1-ethylpyridinium, 1-butylpyridinium, ...
Tópico(s): Electrochemical sensors and biosensors
2017 - Elsevier BV | Journal of Hazardous Materials
Paola D’Errigo, Marco Ranucci, Remo Daniel Covello, Fausto Biancari, Stefano Rosato, Marco Barbanti, Francesco Onorati, Corrado Tamburino, Gennaro Santoro, Claudio Grossi, Francesco Santini, Katia Bontempi, Danilo Fusco, Fulvia Seccareccia,
To evaluate outcomes of monitored anesthesia care (MAC) compared with general anesthesia (GA) in patients undergoing transfemoral transcatheter aortic valve replacement (TAVR).Secondary analysis from the observational and prospective OBSERVANT (OBservational Study of Effectiveness of avR-taVi procedures for severe Aortic steNosis Treatment) study.Multicenter study, including Italian hospitals performing TAVR interventions.One thousand four hundred ninety-four patients with severe and symptomatic aortic ...
Tópico(s): Aortic Disease and Treatment Approaches
2016 - Elsevier BV | Journal of Cardiothoracic and Vascular Anesthesia
Debora Fabbri, Paola Calza, D. Dalmasso, Paul Chiarelli, Valentina Santoro, Claudio Medana,
Conventional wastewater treatment methods have shown to be unsuitable for a complete elimination of iodinated X-ray contrast agents (ICMs), which have thus been found in wastewater treatment plant (WWTP) effluent and in surface water. Once in the surface water, they could be transformed through different processes and form several transformation products that may need to be monitored as well. To this end, we studied the abatement and transformation of ICMs by combining laboratory experiments with ...
Tópico(s): Advanced Photocatalysis Techniques
2016 - Elsevier BV | The Science of The Total Environment
Stefano Rosato, Francesco Santini, Marco Barbanti, Fausto Biancari, Paola D’Errigo, Francesco Onorati, Corrado Tamburino, Marco Ranucci, Remo Daniel Covello, Gennaro Santoro, Claudio Grossi, Martina Ventura, Danilo Fusco, Fulvia Seccareccia,
Background— The proven efficacy of transcatheter aortic valve implantation (TAVI) in high-risk patients is leading to the expansion of its indications toward lower-risk patients. However, this shift is not supported by meaningful evidence of its benefit over surgical aortic valve replacement (SAVR). This analysis aims to describe outcomes of TAVI versus SAVR in low-risk patients. Methods and Results— We compared the outcome after TAVI and SAVR of low-risk patients (European System for Cardiac Operative ...
Tópico(s): Aortic Disease and Treatment Approaches
2016 - Lippincott Williams & Wilkins | Circulation Cardiovascular Interventions
Maurício Lima, Duncan A. Christie, M. Calogero Santoro, Claudio Latorre,
Socio-economic and environmental changes are well known causes of demographic collapse of agrarian cultures. The collapse of human societies is a complex phenomenon where historical and cultural dimensions play a key role, and they may interact with the environmental context. However, the importance of the interaction between socio-economic and climatic factors in explaining possible breakdowns in Native American societies has been poorly explored. The aim of this study is to test the role of socio- ...
Tópico(s): Pacific and Southeast Asian Studies
2016 - Public Library of Science | PLoS ONE
Chiara Martano, Vera Mugoni, Federica Dal Bello, Massimo Santoro, Claudio Medana,
The analysis of lipid molecules in living organism is an important step in deciphering metabolic pathways. Recently, the zebrafish has been adopted as a valuable animal model system to perform in vivo metabolomics studies, however limited methodologies and protocols are currently available to investigate zebrafish lipidome and even fewer to analyze specific classes of lipids. Here we present an HPLC–HRMS based method to rapidly measure multiple prenol lipid molecules from zebrafish tissues. In particular, ...
Tópico(s): Vitamin K Research Studies
2015 - Elsevier BV | Journal of Chromatography A
Davide Vione, Paola Calza, Federico Galli, Debora Fabbri, Valentina Santoro, Claudio Medana,
The aquatic environmental fate of ethylhexyl methoxy cinnamate (EHMC), one of the most used UVB filters worldwide, was studied by assessing its environmental persistence and photoinduced transformations. The role of direct and indirect photolysis was evaluated. Direct photolysis was shown to play a key role, and this process is expected to be the main attenuation route of EHMC in sunlit surface waters. In contrast, the reaction with OH radicals would be negligible and that with 3CDOM* would at most ...
Tópico(s): Indoor Air Quality and Microbial Exposure
2015 - Elsevier BV | The Science of The Total Environment
Fausto Biancari, Stefano Rosato, Paola D’Errigo, Marco Ranucci, Francesco Onorati, Marco Barbanti, Francesco Santini, Corrado Tamburino, Gennaro Santoro, Claudio Grossi, Remo Daniel Covello, Martina Ventura, Danilo Fusco, Fulvia Seccareccia,
A few studies recently reported controversial results with transfemoral transcatheter aortic valve replacement (TF-TAVR) versus transapical transcatheter aortic valve replacement (TA-TAVR), often without adequate adjusted analysis for baseline differences. Data on patients who underwent TF-TAVR and TA-TAVR from the Observational Study of Effectiveness of avR–tavI procedures for severe Aortic stenosis Treatment study were analyzed with propensity score 1-to-1 matching. From a cohort of 1,654 patients ( ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2015 - Elsevier BV | The American Journal of Cardiology
Dulce Calçada, D. Vianello, Enrico Giampieri, Claudia Sala, Gastone Castellani, Albert A. de Graaf, Bas H. A. Kremer, Ben van Ommen, Edith J. M. Feskens, Aurelia Santoro, Claudio Franceschi, Jildau Bouwman,
Aging is a biological process characterized by the progressive functional decline of many interrelated physiological systems. In particular, aging is associated with the development of a systemic state of low-grade chronic inflammation (inflammaging), and with progressive deterioration of metabolic function. Systems biology has helped in identifying the mediators and pathways involved in these phenomena, mainly through the application of high-throughput screening methods, valued for their molecular ...
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2014 - Elsevier BV | Mechanisms of Ageing and Development
Maria Giulia Bacalini, Simonetta Friso, Fabiola Olivieri, Chiara Pirazzini, Cristina Giuliani, Miriam Capri, Aurelia Santoro, Claudio Franceschi, Paolo Garagnani,
The rapid technological advancements achieved in the last years have boosted the progressive identification of age-associated epigenetic changes. These studies not only contribute to shed light on the molecular basis of ageing and age-related diseases but, given the plasticity of epigenetic modifications, also provide the basis for anti-ageing interventions to counteract the onset of age-related diseases. In this review we will discuss nutritional interventions as a promising approach that can positively ...
Tópico(s): Birth, Development, and Health
2014 - Elsevier BV | Mechanisms of Ageing and Development
Produção Nacional
Revisado por pares
Alberto Santoro, Cláudio J. Struchiner, Carmen Felipe, Hélio Tedesco‐Silva, José Osmar Medina Pestana, Guilherme Suarez‐Kurtz,
Clinical Pharmacology & TherapeuticsVolume 94, Issue 2 p. 201-202 Letters to the Editor CYP3A5 Genotype, but Not CYP3A4*1b, CYP3A4*22, or Hematocrit, Predicts Tacrolimus Dose Requirements in Brazilian Renal Transplant Patients A B Santoro, A B Santoro Programa de Farmacologia, Instituto Nacional de Câncer, Rio de Janeiro, BrazilSearch for more papers by this authorC J Struchiner, C J Struchiner Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, BrazilSearch for more papers by ...
Tópico(s): Epilepsy research and treatment
2013 - Wiley | Clinical Pharmacology & Therapeutics
Giuseppina Mattace Raso, Raffaele Simeoli, Roberto Russo, Anna Santoro, Claudio Pirozzi, Roberta d’Emmanuele di Villa Bianca, Emma Mitidieri, Orlando Paciello, Teresa Bruna Pagano, Nicola Salvatore Orefice, Rosaria Meli, Antonio Calignano,
Hypertension is an important risk factor for kidney failure and renal events in the general population. Palmitoylethanolamide (PEA) is a member of the fatty acid ethanolamine family with profound analgesic and anti-inflammatory effects, resulting from its ability to activate peroxisome proliferator activated receptor (PPAR)α. A role for this nuclear receptor has been addressed in cardiovascular system and PPARα ligands have been shown to protect against inflammatory damage especially resulting from ...
Tópico(s): Liver Disease Diagnosis and Treatment
2013 - Elsevier BV | Pharmacological Research
Pablo A. Marquet, Calógero M. Santoro, Claudio Latorre, Vivien G. Standen, Sebastián Abades, Marcelo M. Rivadeneira, Bernardo Arriaza, Michael Hochberg,
The emergence of complex cultural practices in simple hunter-gatherer groups poses interesting questions on what drives social complexity and what causes the emergence and disappearance of cultural innovations. Here we analyze the conditions that underlie the emergence of artificial mummification in the Chinchorro culture in the coastal Atacama Desert in northern Chile and southern Peru. We provide empirical and theoretical evidence that artificial mummification appeared during a period of increased ...
Tópico(s): Pacific and Southeast Asian Studies
2012 - National Academy of Sciences | Proceedings of the National Academy of Sciences