Ann Meloy, Nick Nuttall, Patricia Davies, Simon Barnes, Jill Sherman Political Correspondent, David Rhys Jones, John Diamond, Ivo Tennant, Ross Tieman, Industrial Correspondent, Philip Howard, Michael Binyon, Barry Turner, James Bone, Richard Streeton, Debra Isaac, Neil Bennett, Banking Correspondent, Tom Walker, Desmond Dearlove, Richard Abramson, Geoff Brown, Ruth Evans, Director, Michael Tate, City Editor, Jeremy Laurance, Health Services Correspondent, Martin Fletcher, G. Spencer-Brown, George Darwall, Charles Keen, Kurt Schork, Peter Ball, Jim French, Chairman, Bosnia Battle, Rachel Kelly, Fiona Reynolds, Basil Hume, Peter Ackroyd, Jeremy Laurance Health Services Correspondent, Richard Ford Home Correspondent, Alan Hamilton, Trevor Mound, Rodney Milnes, Robert Bruce, Michael Clark, R. E. Gutch, Chief Executive, Philip Robinson, Michael Hamlyn, John Hennessy, Conor Cruise O'Brien, Robert Cockburn, Sidney Brichto (Senior Vice-President), Jack Waterman, Dick Hinder, Fred Tuckman, President, Michael Theodoulou, Sydney Friskin, Dennis Signy, Anatole Kaletsky, Economics Editor, David Miller, Lin Jenkins, Philip Webster, Chief Political Correspondent, Geoffrey Wheeler, Ian Brunskill, Alison Roberts, David Powell Athletics Correspondent, Lindsay Cook, Money Editor, Kerry Gill, Jonathan Prynn, Alan Lee, Cricket Correspondent, Raymond Keene, Chess Correspondent, Craig Brown, Alix Ramsay, Randolph Quirk, Robin Neillands, David Davis, Michael Hamlyn and Ray Kennedy, John Cherry, Valerie Goldberg, Russell L. Ackoff, R. W. Johnson, Harvey Elliott, Travel Correspondent, John Goodbody, Philip Webster Chief Political Correspondent, Jeremy Rowe, Chairman, Christopher Hawtree, John Paxton, Ben MacIntyre, Richard Beeston, Michael Phillips, Jasper Becker, Chris Dighton, Godfrey Golzen, Tim Jones, William Cash, Martin Waller, David Blackmore (Operations Director), Christopher Follett, Benedict Nightingale, James R. Mancham (President), David Powell, Richard Morrison, Arthur Leathley, Michael Evans, Matthew Bond, Colin Campbell, Walter Ellis, Mary Dejevsky, Michael Hornsby Agriculture Correspondent,
... minimum of fuss American gives positive test for clenbuterol Robb and Grindley find going tough Arsenal call ...
1992 - Gale Group | TDA
Qinghui Guo, Yankun Peng, Kuanglin Chao, Jianwei Qin, Yahui Chen, Tianzhen Yin,
Clenbuterol is often used as a feed additive to increase the percentage of lean meat in livestock. Meat containing clenbuterol can cause many illnesses and even death for ... effectiveness of gold colloids of different sizes on clenbuterol in pork was investigated. The results showed that ... gold colloid with the best enhanced effectiveness for clenbuterol had a particle size of approximately 90 nm. ... a sample collection component was designed to detect clenbuterol from bottom to top, solving the problem of ...
Tópico(s): Mass Spectrometry Techniques and Applications
2023 - Elsevier BV | Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
Phil Yates, Julia Llewellyn Smith, Jon Ashworth, David Adams, Nick Nuttall, Nicholas Wood, Political Correspondent, Flowers, Christopher Thomas, South Asia Correspondent, Edward Gorman Ireland Correspondent, Richard Ford, Home Correspondent, Jean Henderson, Bill Frost, Tim Judah, Sheila Gunn, Political Correspondent, Bernard Kaukas, Peter Riddell, Political Editor, P W R Robeson, Angela MacKay, Matt Wolf, Peter Judge, D. R. Pinyoun, L. E. J. Roberts, James Bone, Melinda Wittstock, Media Correspondent, Richard Streeton, Kevin Eason, Motoring Correspondent, Debra Isaac, Sean Hallahan, Matthew D'ancona, Education Correspondent, J. K., Kevin Eason, S. T. Eason, Ruth Evans, Director, Gerald Davies, Philip Bassett Industrial Editor, Martin Fletcher, Mitchell Platts, Golf Correspondent, Andrew Longmore Tennis Correspondent, Jane Bird, Dessa Trevisan, Tim Judah, Bruce Clark, J. Triseliotis, Ian Guyster, Patricia Tehan, Malcolm Green, Director, James Bone and Sam Kiley, Brian Hulme, Retired Chairman, Raymond Keene Chess Correspondent, Louise Taylor, Matthew May, Ruth Gledhill Religion Correspondent, Richard Ford Home Correspondent, Godfrey Dodds, Alan Hamilton, Robin Young, John Hart, Michael Clark, Philip Robinson, John Young, David Guest, John Percival, Peter Barnard, Michael Binyon Diplomatic Editor, Richard Cork, Adam Lebor, J. J. R. Dirks, Anatole Kaletsky, Economics Editor, Philip Webster, Chief Political Correspondent, Jill Sherman and Nicholas Wood, David Powell Athletics Correspondent, Jonathan Prynn, John Russell Taylor, Raymond Keene, Chess Correspondent, Craig Brown, Frances Gibb, Legal Correspondent, Ian Kelcey, Anthony Swainson, Director, Alice Thomson, Dennis Beard, Barry Pickthall, Sally Tomlinson, Richard Evans Miami, Rodney Hobson, Michael Dynes, Transport Correspondent, B. N., Pamela Wightwick, Robin Stacey, Joanna Pitman, David Young, John Goodbody, Edward Gorman and George Brock, James Pringle, Srikumar Sen Boxing Correspondent, Matthew Parris, Christopher Bishop, Caitlin Moran, Walter Gammie, Peter Riddell, Ben MacIntyre, Benedict Nightingale and Jeremy Kingston, Chris Dighton, Nadine Meisner, David Crawford, Graham Mather, Melinda Wittstock, Simon Jenkins, Tim Jones, William Cash, Martin Waller, David Sinclair, Michael Horsnell, Nigel Hawkes Science Editor, Frances Gibb Legal Correspondent, Hugh Thompson, David Penfold, Veronica Heath, Anne McElvoy, Alan Jackson, Colin Campbell, David Hands, Rugby Correspondent, Christopher Irvine,
... Redland girls to pioneer rugby Schools Sport The clenbuterol loophole John Goodbody examines the curious background to ...
1992 - Gale Group | TDA
Jon Nissen‐Meyer, Tore Skotland, Erik Boye,
... Polish canoeist Adam Seroczynski who tested positive for clenbuterol during the 2008 Olympics in Beijing, China. Since clenbuterol was used in the production of meat in ... detected in his urine, he argued that the clenbuterol came from food consumption. He also maintained that ... CAS hearing, Seroczynski's defence argued that the clenbuterol concentration in his urine was less than 0. ... out that there had been an epidemic of clenbuterol-"poisoning" due to contaminated beef in Spain (1992), ... in two persons with 2 and 4 ng clenbuterol per ml urine (https://www.doping.nl/media/ ...
Tópico(s): Sports Analytics and Performance
2022 - Springer Nature | EMBO Reports
Philip Webster and Sheila Gunn, Stephen Bush, Andrew Robathan, Kenneth Minogue, Jon Ashworth, Roger Boyes, East Europe Correspondent and Michael Binyon, Diplomatic Editor, David Adams, Nicholas Wood, Political Correspondent, Edward Gorman Ireland Correspondent, Ross Tieman, Industrial Correspondent, Karl Knight, Philip Howard, Sarah Mower, Vinson, Jeremy Kingston, Angela Browning, Noel Goodwin, Carol Leonard, Richard Streeton, Alan Duncan, Nicholas Wood and Jill Sherman, Basil Feldman (Chairman), Tony Patrick, Roddy Forsyth, Peter Riddell Political Editor, Gerald Davies, Thunderer, Martin Fletcher, Michael Dynes Transport Correspondent, Ralph Harris, Brian Hindley, Patricia Tehan, John Browne, Caroline Sullivan, Roger Graef, Louise Taylor, Rachel Kelly, Lionel Bloch, Liam Fox, Nigel Waterson, Libby Purves, Jeremy Laurance Health Services Correspondent, Philip Webster, Chief Political Correspondent, and George Brock, René Riley-Adams, Alan Hamilton, Robin Young, Nigel Evans, John Mason (Chairman), Charles Bremner, Joseph Connolly, Neil Bennett Banking Correspondent, Philip Bassett, Industrial Editor, Michael Binyon Diplomatic Editor, Peter Lewis, Derwent May, Kate Muir, Pete Challis (Chair), David Faber, Wolfgang M?nchau, Russell Kempson, Richard Cork, Martin Fletcher and Kate Muir, Lindsay Cook, Martin Hoyle, Nicholas Harling, Phil Gallie, David Miller, Alan Toogood, Horticulture Correspondent, David Toop, R. D. A. Pick, Lindsay Cook, Money Editor, Robert McLean, Raymond Keene, Chess Correspondent, Matthew D'ancona, Selina Scott, P. A. D. Dole-Thomas, Craig Brown, Frances Gibb, Legal Correspondent, Diana Allen, Alan Ryan, David Willetts, Nick Hawkins, David Lidington, Geoffrey Clifton-Brown, Barry Pickthall, Arthur Cowgill (Director), Ian Ross, Bryan Appleyard, Martin Holmes, Sheila Vince, Jamie Dettmer, John Sykes, Swaythling, Joanna Pitman, John Goodbody, Mandarin, Colin Narbrough, Economics Correspondent, Charles Hendry, Matthew Parris, Graham Searjeant Financial Editor, G. B. Miller, David Wolfson, Richard Beeston and Tim Judah, Keith Kemp, Michael Austin, Ben MacIntyre, J. E. Garfitt, Michael Phillips, Nadine Meisner, Simon Jenkins, Philip Pangalos, Michael Binyon, Diplomatic Editor, Tim Jones, Anthony Morris, Arthur Leathley, Anne McElvoy, Martin Waller Deputy City Editor, Alan Jackson, Matthew Bond, Anthony Howard, Peter Willsher, Keith Joseph, H. D. Berman, David Hands, Rugby Correspondent, Roy Thomason, Andrew Longmore, Tennis Correspondent, Colin McQuillan, B. C. Roberts, Sam Kiley, Africa Correspondent, Stuart Jones, Football Correspondent, Wolfgan M?nchau, European Business Correspondent,
... Squash Yesterday's Results Shot putter admits taking clenbuterol during AAAs event Drugs in Sport TCCB ruling ...
1992 - Gale Group | TDA
Qinghui Guo, Yankun Peng, Xinlong Zhao, Yahui Chen,
Clenbuterol (CB) is a synthetic β-receptor agonist which can be used to improve carcass leanness in ... used to achieve rapid detection and identification of clenbuterol hydrochloride (CB) residues. First, the effects of several ... efficiency were compared, and it was found that clenbuterol in pork had a better enhancement effect using ... as an extraction agent. Then, SERS signals of clenbuterol in different solvents were compared, and it was found that clenbuterol had a better enhancement effect in an aqueous ...
Tópico(s): Pesticide Residue Analysis and Safety
2022 - Multidisciplinary Digital Publishing Institute | Biosensors
Alice Thomson Political Staff, Phil Yates, Liz Dolan, Lynne Greenwood, Paul Heiney, Gillian Bowditch Scotland Correspondent, Donald Clarke, Des Keenan, John Vincent, Rob Hughes, Rose Wild, Simon Barnes, Rob Hughes, football correspondent, Jane MacQuitty, Alison Roberts Arts Reporter, Jill Sherman Political Correspondent, Ronald Faux, David Rhys Jones, John Diamond, Anne McElvoy, Moscow Correspondent, Philip Howard, Hilary Finch, Cyril Cunningham, Ian Murray, Alexandra Frean Media Correspondent, Clive Davis, Albert Dormer, Carl Mortished, Steven Meisel, Colin Narbrough, World Trade Correspondent, Francesca Greenoak, Martin Fletcher, Ruth Gledhill, Religion Correspondent, Stuart Jones, Alan Lorimer, Peter Ball, Martin Flanagan, Ruth Gledhill, H. G. Jerrard, J. Byron-Archer, Nigel Williams, Keith Pike and Peter Ball, Alison Roberts, Arts Reporter, Heather Newman, Lia Williams, Michael Evans, Defence Correspondent, Gerald Isaaman, (Editor), Robin Young, Louise Hidalgo, Michael Clark, Clive Anderson, Philip Robinson, Mel Batty's, Keith Pike, Kevin Eason Motoring Correspondent, David Hands, Charles Bremner, Philip Bassett, Industrial Editor, Derwent May, Susan Gilchrist, Margaret Dibben, James Hepburn, Sydney Friskin, R. D. R. Probert, Jill Insley, John Wijngaards, John Higgins, Charles Jennings, David Powell Athletics Correspondent, Darrel Rees, Melvyn Marckus City Editor, Raymond Keene, Jonathan Prynn, Peter Davalle, Frances Gibb, Legal Correspondent, Richard Southwood, Peter Bryan, John Vincent and Marianne Curphey, Robert Payne, Richard Evans, Moy McCrory, Alice Thomson, Harry Greenway, Barry Pickthall, Roger Boyes, Nigel Hawkes, Science Editor, Raymond Keene and Daniel Johnson, Ian Wisniewski, Barry Shooter, Derek Richards, Philip Webster, Political Editor, John Sherlock, David Hands Rugby Correspondent, Julian Muscat, Nicholas Wood, Chief Political Correspondent, Desmond Hartley, Christopher Thomas, John Goodbody, Jane Bidder, Ross Tieman Industrial Correspondent, Coomi Kapoor and Robi Dutta, Srikumar Sen Boxing Correspondent, Matthew Parris, Louisa Young, Richard Evans Racing Correspondent, Ronald Millar, Frank Jeffery, S. R. L. Green, Ellen Cranitch, Christine Wheeler, Arthur H. Doe, Ben MacIntyre, Ian Brodie, D. Cowe, Stephanie Trotter, Simon Jenkins, Hattie Ellis, Stephen Pettitt, Nigel Hawkes Science Editor, Tom White, Chief Executive, Jonathan Meades, Ted Cunningham, Anne McElvoy, Andrew Morris, Lindsay Cook Deputy Business Editor, Susan MacDonald, Fiona Beckett, Andrew Finkel, John Phillips, Matthew Bond, Ross Tieman, Rosanna Greenstreet, Conal Gregory, J. Joseph, Edward Marriott, Christopher Irvine, Peter Gray (Director),
... the Press Growth drug found in supermarket pate Clenbuterol, taken secretly by athletes, is also used to ...
1993 - Gale Group | TDA
Qinghui Guo, Yankun Peng, Kuanglin Chao, Qibin Zhuang, Yahui Chen,
Clenbuterol and ractopamine can be used to improve carcass leanness in swine, but their residues in pork ... to establish MLR and PLSR prediction models for clenbuterol and ractopamine, respectively, to achieve rapid detection and identification of ractopamine (RAC) and clenbuterol hydrochloride (CL) residues. In this report, the detection of clenbuterol and ractopamine was carried out using three gold ... SERS spectra of 0.1–10 µg/mL clenbuterol and ractopamine solution were collected by using NaCl ... at each characteristic peak and the concentration of clenbuterol and ractopamine, respectively. The results show that the ...
Tópico(s): Pesticide Residue Analysis and Safety
2022 - Elsevier BV | Vibrational Spectroscopy
Sten M. M. van Beek, Anastasia V. Kalinovich, Gert Schaart, Tore Bengtsson, Joris Hoeks,
Prolonged supplementation with the β2-agonist clenbuterol improves glucose homeostasis in diabetic rodents, likely via β2-adrenoceptor (β2-AR)-mediated effects in the skeletal muscle and liver. However, since ... substantial quantities of brown adipose tissue (BAT) and clenbuterol has affinity to β1- and β3-ARs, the ... to these improvements is unclear. Therefore, we investigated clenbuterol-mediated improvements in glucose homeostasis in uncoupling protein ... C57Bl/6 mice were injected with saline or clenbuterol and whole body oxygen consumption was measured. Furthermore, ...
Tópico(s): Cardiovascular Disease and Adiposity
2021 - American Physiological Society | AJP Endocrinology and Metabolism
Sara Amalie Solheim, Søren Jessen, Jakob Mørkeberg, Mario Thevis, Yvette Dehnes, Kasper Eibye, Morten Hostrup, Nikolai Baastrup Nordsborg,
Abstract Clenbuterol is a β 2 ‐agonist prescribed for asthmatic patients in some countries. Based on its anabolic and ... rodents and in livestock destined for food production, clenbuterol is abused by bodybuilders and athletes seeking leanness. Urinary clenbuterol analysis is part of routine doping analysis. However, ... as an alternative matrix, but the detectability of clenbuterol in humans through DBS has not been investigated. This study evaluated if clenbuterol could be detected in DBS and urine collected ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2020 - Wiley | Drug Testing and Analysis
Søren Jessen, Sara Amalie Solheim, Glenn A. Jacobson, Kasper Eibye, Jens Bangsbo, Nikolai Baastrup Nordsborg, Morten Hostrup,
Abstract Clenbuterol is a beta 2 ‐adrenoceptor agonist marketed as an asthma reliever but is not approved for human ... its demonstrated hypertrophic and lipolytic actions in rodents, clenbuterol is one of the most widely abused doping ... seeking leanness. Herein, we examined the effect of clenbuterol ingestion on metabolic rate as well as skeletal ... and 140 min after ingestion of 80 μg clenbuterol, resting metabolic rate and contractile function of the ... well as vastus lateralis muscle biopsies were collected. Clenbuterol increased resting energy expenditure by 21% ( P < 0. ...
Tópico(s): Cardiovascular and exercise physiology
2019 - Wiley | Drug Testing and Analysis
Benjamín Velasco‐Bejarano, Jahir Bautista, Ma. Olivia Noguez, Evangelina Camacho, Martha E. Rodríguez, Leonardo Rodríguez,
... in racemic mixtures for performance enhancement. These include clenbuterol, methyl hexaneamine, methamphetamines, and amphetamines. Clenbuterol is present in a large number of doping ... the result of consumption of meat contaminated with clenbuterol. In other cases, the origin is not clear. In this study, 27 products with racemic clenbuterol were evaluated using a new analytical methodology for the resolution of R-(-) and S-(+)-enantiomers of clenbuterol by liquid chromatography-tandem mass spectrometry (LC-MS/ ...
Tópico(s): Veterinary Pharmacology and Anesthesia
2017 - Wiley | Drug Testing and Analysis
Guillaume Py, Christelle Koechlin‐Ramonatxo, Pascal Sirvent, Anthony M. J. Sanchez, Antony Philippe, Aymeric Douillard, Olivier Galbès, Corinne Lionne, Anne Bonnieu, Angèle Chopard, Olivier Cazorla, Alain Lacampagne, Robin Candau,
Key points Clenbuterol is an adrenergic receptor agonist known to induce skeletal muscle hypertrophy and a shift towards faster muscle fibres, ... fast contracting muscle. Our data show that chronic clenbuterol treatment reduces contractile efficiency, with altered contraction and ... contraction could partially explain these deleterious effects. Abstract Clenbuterol is a β 2 ‐adrenergic receptor agonist known ... study was to test the effects of chronic clenbuterol treatment on contractile efficiency and explore the underlying ...
Tópico(s): Cardiovascular and exercise physiology
2015 - Wiley | The Journal of Physiology
Aniko Krumbholz, Patricia Anielski, Lena Gfrerer, Matthias Graw, Hans Geyer, Wilhelm Schänzer, Jiří Dvořák, Detlef Thieme,
Clenbuterol is a well‐established β2‐agonist, which is prohibited in sports and strictly regulated for use ... the livestock industry. During the last few years clenbuterol‐positive results in doping controls and in samples ... suspected to be related the illegal use of clenbuterol for fattening. A sensitive liquid chromatography‐tandem mass ... MS/MS) method was developed to detect low clenbuterol residues in hair with a detection limit of ... application study, a total dosage of 30 µg clenbuterol was applied to 20 healthy volunteers on 5 ...
Tópico(s): Veterinary Pharmacology and Anesthesia
2014 - Wiley | Drug Testing and Analysis
Pascal Sirvent, Aymerick Douillard, Olivier Galbès, Christelle Koechlin‐Ramonatxo, Guillaume Py, Robin Candau, Alain Lacampagne,
Clenbuterol, a β2-agonist, induces skeletal muscle hypertrophy and a shift from slow-oxidative to fast-glycolytic ... the cellular mechanisms of the effects of chronic clenbuterol administration on skeletal muscle are not completely understood. ... study was to investigate the effects of chronic clenbuterol treatment on force, fatigue, intracellular calcium (Ca2+) homeostasis ... EDL, muscle), as they are more sensitive to clenbuterol-induced hypertrophy. Male Wistar rats were chronically treated with 4 mg.kg−1 clenbuterol or saline vehicle (controls) for 21 days. Confocal ...
Tópico(s): Sports Performance and Training
2014 - Public Library of Science | PLoS ONE
Iori Hirosawa, Mai Ishikawa, Mio Ogino, Hiroshi Ito, Takuya Hirao, Harumi Yamada, Mariko Asahi, Hajime Kotaki, Yoshimichi Sai, Ken–ichi Miyamoto,
ABSTRACT Clenbuterol is a long‐acting β2‐adrenoceptor agonist and bronchodilator that is used for the treatment of asthma, ... This study examined enantioselectivity in the disposition of clenbuterol following administration of clenbuterol racemate to rats. Concentrations of clenbuterol enantiomers in plasma, urine and bile were determined ... to show high sensitivity, specificity and precision, and clenbuterol enantiomers in 0.1 ml volumes of plasma ... 0.25 ng/ml. The pharmacokinetic profiles of clenbuterol enantiomers following intravenous and intraduodenal administration of clenbuterol ...
Tópico(s): Asthma and respiratory diseases
2013 - Wiley | Biopharmaceutics & Drug Disposition
Mario Thevis, Andreas Thomas, Simon Beuck, Anthony W. Butch, Jiří Dvořák, Wilhelm Schänzer,
RATIONALE Clenbuterol (4‐amino‐α‐[( tert ‐butylamino)methyl]‐3,5‐dichlorobenzyl alcohol) is approved for human and veterinary use ... in cases of medical indications, the misuse of clenbuterol in animal husbandry as well as elite and ... various recent incidences of doping control specimens containing clenbuterol, strategies towards the discrimination of a surreptitious application ... supplements were required. METHODS The enantiomeric compositions of clenbuterol in human urine samples derived from administration studies ...
Tópico(s): Veterinary Pharmacology and Anesthesia
2013 - Wiley | Rapid Communications in Mass Spectrometry
Katie J. Ryan, Éadaoin W. Griffin, Justin Yssel, Karen M. Ryan, Eóin N. McNamee, Andrew Harkin, Thomas J. Connor,
... the long-acting brain penetrant β2-adrenoceptor agonist clenbuterol on NFκB activity and IκB expression in rat brain. Clenbuterol decreased NFκB activity (p65 DNA binding) in nuclear ... the suppression NFκB activity observed. These actions of clenbuterol were prevented by pre-treatment with the non- ... adrenoceptor antagonist metoprolol, suggesting that the effects of clenbuterol on IκBα expression and NFκB activity are mediated ... the β2-adrenoceptor. In addition, the actions of clenbuterol were mimicked by systemic administration of another highly ...
Tópico(s): Cancer, Stress, Anesthesia, and Immune Response
2013 - Elsevier BV | Neurochemistry International
Jingying Jia, Lunan Zhang, Youli Lu, Mengqi Zhang, Gangyi Liu, Yanmei Liu, Chuan Lü, Shuijun Li, Yi Lü, Ruiwen Zhang, Yu Chen,
The illegal use of clenbuterol has been an increasingly serious issue in today's livestock products industry. It becomes an important project to develop a ... LC-MS/MS method was developed to detect clenbuterol residue in hair, with the low limit of ... 5ng/g. Hogs fed with 340µg/day of clenbuterol for 2 weeks were found a high clenbuterol residue in their hair approximately at 1-2 months after withdrawal. There remained 3.31ng/g clenbuterol in hog hair approximately 5 months after the ... hogs whose dark hair obviously had a higher clenbuterol residue than the light ones (p=0.017, ...
Tópico(s): Veterinary Pharmacology and Anesthesia
2013 - Elsevier BV | Ecotoxicology and Environmental Safety
Mario Thevis, Lina Geyer, Hans Geyer, Sven Guddat, Jiří Dvořák, Anthony W. Butch, Saskia S. Sterk, Wilhelm Schänzer,
... to illegally increase the benefit of stock farming, clenbuterol has held a unique position due to the ... composition, mechanism of action, metabolism, and disposition. Particularly clenbuterol's disposition in animals' edible tissues destined for ... study. Triggered by five adverse analytical findings with clenbuterol among the Mexican national soccer team in out- ... In 14 out of 47 meat samples (30%), clenbuterol was detected at concentrations between 0.06 and ... out of 208 doping control specimens (52%) yielded clenbuterol findings at concentrations ranging from 1-1556 pg/ ...
Tópico(s): Veterinary Pharmacology and Anesthesia
2013 - Wiley | Drug Testing and Analysis
Shuyun Bi, Bo Pang, Tianjiao Wang, Tingting Zhao, Y. Wang,
Clenbuterol interacting with bovine serum albumin (BSA) or lysozyme (LYS) in physiological buffer (pH 7.4) was ... UV–vis absorption spectroscopy. The results indicated that clenbuterol quenched the intrinsic fluorescence of BSA and LYS ... a static quenching procedure. The binding constants of clenbuterol with BSA and LYS were 1.16 × 103 ... played a major role in stabilizing the complex (clenbuterol–BSA or clenbuterol–LYS). In the presence of Fe2+, Fe3+, Cu2+, Mg2+, Ca2+, or Zn2+, the binding constants of clenbuterol to BSA or LYS had no significant differences. ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2013 - Elsevier BV | Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
T Abo, Ryohei Iida, Syuhei Kaneko, Takeo Suga, Hiroyuki Yamada, Yoshiki Hamada, Akira Yamane,
Clenbuterol, a β 2 ‐adrenergic agonist, increases the hypertrophy of skeletal muscle. Insulin‐like growth factor (IGF) ... work as a potent positive regulator in the clenbuterol‐induced hypertrophy of skeletal muscles. However, the precise ... for the hypertrophy of skeletal muscle induced by clenbuterol is unknown. Myostatin, a member of the TGF ... the hypertrophy of rat masseter muscle induced by clenbuterol. To investigate the function of myostatin and IGF in regulatory mechanism for the clenbuterol‐induced hypertrophy of skeletal muscles, we analysed the ...
Tópico(s): Adipose Tissue and Metabolism
2012 - Wiley | Cell Biochemistry and Function
... neurohormonal blockade (phase I) followed by high-dose clenbuterol (phase II), 12 (60%) of the study cohort ... of heart failure medications, followed by high-dose clenbuterol. All patients had a nonischemic etiology, and most ( ... The authors reported that 75% of patients receiving clenbuterol could undergo LVAD explantation and 46% of all ... received both maximal neurohormonal blockade and high-dose clenbuterol. Results from the US HARPS study will be ... protocol (phase I, conventional neurohormonal blockade; phase II, clenbuterol) should be addressed.We have limited guidelines about ...
Tópico(s): Cardiac Arrest and Resuscitation
2011 - Lippincott Williams & Wilkins | Circulation
Jelka Pleadin, Ana Vulić, Mario Mitak, Nina Perši, Dinka Milić,
... present study was to assess the persistence of clenbuterol residues in retinal tissue of pigs after repeated ... for quantitative determination. A growth-promoting dose of clenbuterol (20 μg/kg body mass per day) was ... whereas control animals (n = 3) were left untreated. Clenbuterol-treated pigs were randomly sacrificed (n = 3) on days 0 and 45 of treatment discontinuation, and clenbuterol residues were determined in retinal tissue dissected from ... found to be acceptable for quantitative determination of clenbuterol in retinal samples because previous method validation yielded ...
Tópico(s): Veterinary Pharmacology and Anesthesia
2011 - Oxford University Press | Journal of Analytical Toxicology
Guichi Zhu, Yongjun Hu, Jiao Gao, Liang Zhong,
... report, we present a novel approach to detect clenbuterol based on competitive surface-enhanced Raman scattering (SERS) ... is labeled by 4,4′-dipyridyl (DP) and clenbuterol antibody, respectively. The detection of clenbuterol is carried out by competitive binding between free clenbuterol and clenbuterol-BSA fastened on the substrate with their antibody ... nanoprobes. The present method allows us to detect clenbuterol over a much wider concentration range (0.1– ... use of this new competitive SERS immunoassay, the clenbuterol-BSA (antigen) is chosen to fasten on the ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2011 - Elsevier BV | Analytica Chimica Acta
Jelka Pleadin, Ana Vulić, Nina Perši, Nada Vahčić,
... this study was to determine the level of clenbuterol residues in muscle tissue of pigs after repeat ... a growth-promoting dose. An anabolic dose of clenbuterol (20 μg/kg body mass per day) was ... whereas control animals (n=3) were left untreated. Clenbuterol treated pigs were randomly sacrificed (n=3) on ... 3, 7 and 14 of treatment discontinuation and clenbuterol residues determined in muscle tissue. Determination of residual clenbuterol was by enzyme-linked immunosorbent assay (ELISA) as ... MS/MS) as a confirmation method. The highest clenbuterol content in the muscle of treated animals was ...
Tópico(s): Pesticide Residue Analysis and Safety
2010 - Elsevier BV | Meat Science
Katie J. Ryan, Éadaoin W. Griffin, Thomas J. Connor,
Systemic administration of the β2-adrenoceptor agonist clenbuterol induces expression of IL-1β and its negative regulators, interleukin-1 receptor antagonist (IL-1ra) and the interleukin-1 type II decoy receptor (IL-1RII) in rat brain. Clenbuterol also increases central expression of the broad spectrum ... we examine the impact of combined treatment with clenbuterol (0.5 mg/kg) and the glucocorticoid dexamethasone ( ... of IL-1β and iNOS mRNA expression by clenbuterol in all three brain regions, without altering its ...
Tópico(s): Neuropeptides and Animal Physiology
2010 - Elsevier BV | Journal of Neuroimmunology
Qiufang Zhang, Jizhou Xiang, Xuanbin Wang, Hui Liu, Benrong Hu, Mei Feng, Qin Fu,
... evidence indicates that the beta(2)-adrenoceptor agonist clenbuterol decreases apoptosis in a rodent model of ischaemic ... In this study, we investigated the effects of clenbuterol on infarct size caused by myocardial ischaemia/reperfusion ( ... following groups: (i) sham (ii) I/R (iii) clenbuterol + I/R (iv) ICI 118551 + clenbuterol + I/R (v) metoprolol + clenbuterol + I/R (vi) metoprolol + I/R (vii) pertussis toxin + clenbuterol + I/R. Under anaesthesia, left anterior descending coronary ... Compared with the control I/R group,the clenbuterol (0.5 mg.kg(-1), i.p.) group ...
Tópico(s): Receptor Mechanisms and Signaling
2010 - Wiley | British Journal of Pharmacology
Robert A. Ngala, Jacqueline O’Dowd, Steven J. Wang, Claire J. Stocker, Michael A. Cawthorne, Jonathan R.S. Arch,
... previous work, 10 pM BRL37344 and 10 pM clenbuterol stimulated glucose uptake in mouse soleus muscle. Ten nM BRL37344 also stimulated uptake but 100 nM clenbuterol inhibited uptake. Antagonist studies suggested that the opposite effects of 10 nM BRL37344 and 100 nM clenbuterol are mediated by the beta(2)-adrenoceptor. BRL37344 and clenbuterol have been studied in muscles that lack beta( ... Concentration-response relationships were similar for BRL37344 and clenbuterol in normal muscle and muscle lacking beta(3)- ...
Tópico(s): Receptor Mechanisms and Signaling
2009 - Wiley | British Journal of Pharmacology
A. C. Dilger, S.R. Gabriel, L.W. Kutzler, F. K. McKeith, J. Killefer,
... the myostatin (Mstn) null mutation and treatment with clenbuterol both increase muscle growth and decrease fat mass. ... to determine whether mechanistic overlap exists by administering clenbuterol to Mstn null mice. Male Mstn null and ... either 0 (control) or 20 p.p.m. clenbuterol in tap water free choice for 14 days. ... carcasses of Mstn null mice. Similarly, treatment with clenbuterol resulted in increased body and empty carcass weight, ... protein content of empty carcasses was increased with clenbuterol treatment. A significant interaction of genotype and clenbuterol ...
Tópico(s): Muscle metabolism and nutrition
2009 - Elsevier BV | animal