Ann Meloy, Nick Nuttall, Patricia Davies, Simon Barnes, Jill Sherman Political Correspondent, David Rhys Jones, John Diamond, Ivo Tennant, Ross Tieman, Industrial Correspondent, Philip Howard, Michael Binyon, Barry Turner, James Bone, Richard Streeton, Debra Isaac, Neil Bennett, Banking Correspondent, Tom Walker, Desmond Dearlove, Richard Abramson, Geoff Brown, Ruth Evans, Director, Michael Tate, City Editor, Jeremy Laurance, Health Services Correspondent, Martin Fletcher, G. Spencer-Brown, George Darwall, Charles Keen, Kurt Schork, Peter Ball, Jim French, Chairman, Bosnia Battle, Rachel Kelly, Fiona Reynolds, Basil Hume, Peter Ackroyd, Jeremy Laurance Health Services Correspondent, Richard Ford Home Correspondent, Alan Hamilton, Trevor Mound, Rodney Milnes, Robert Bruce, Michael Clark, R. E. Gutch, Chief Executive, Philip Robinson, Michael Hamlyn, John Hennessy, Conor Cruise O'Brien, Robert Cockburn, Sidney Brichto (Senior Vice-President), Jack Waterman, Dick Hinder, Fred Tuckman, President, Michael Theodoulou, Sydney Friskin, Dennis Signy, Anatole Kaletsky, Economics Editor, David Miller, Lin Jenkins, Philip Webster, Chief Political Correspondent, Geoffrey Wheeler, Ian Brunskill, Alison Roberts, David Powell Athletics Correspondent, Lindsay Cook, Money Editor, Kerry Gill, Jonathan Prynn, Alan Lee, Cricket Correspondent, Raymond Keene, Chess Correspondent, Craig Brown, Alix Ramsay, Randolph Quirk, Robin Neillands, David Davis, Michael Hamlyn and Ray Kennedy, John Cherry, Valerie Goldberg, Russell L. Ackoff, R. W. Johnson, Harvey Elliott, Travel Correspondent, John Goodbody, Philip Webster Chief Political Correspondent, Jeremy Rowe, Chairman, Christopher Hawtree, John Paxton, Ben MacIntyre, Richard Beeston, Michael Phillips, Jasper Becker, Chris Dighton, Godfrey Golzen, Tim Jones, William Cash, Martin Waller, David Blackmore (Operations Director), Christopher Follett, Benedict Nightingale, James R. Mancham (President), David Powell, Richard Morrison, Arthur Leathley, Michael Evans, Matthew Bond, Colin Campbell, Walter Ellis, Mary Dejevsky, Michael Hornsby Agriculture Correspondent,
... minimum of fuss American gives positive test for clenbuterol Robb and Grindley find going tough Arsenal call ...
1992 - Gale Group | TDA
R. H. Dalrymple, P.K. Baker, P.E. Gingher, D.L. Ingle, J.M. Pensack, Catherine A. Ricks,
Clenbuterol [benzyl alcohol, 4-amino-alpha-(t-butylamino)methyl-3,5-dichloro] was tested in the finisher ... and carcass characteristics. In Experiment 1, administration of clenbuterol at feed levels of .25, .5, 1, 2, ... levels tested. Uneviscerated body composition analysis indicated that clenbuterol treatment significantly increased body protein and water content ... significantly reduced by 1, 2, and 4 ppm clenbuterol. From these results the 1 ppm level was ... for further testing. In Experiments 2 and 3, clenbuterol fed from 28 to 49 days of age ...
Tópico(s): Pesticide Residue Analysis and Safety
1984 - Elsevier BV | Poultry Science
Phil Yates, Julia Llewellyn Smith, Jon Ashworth, David Adams, Nick Nuttall, Nicholas Wood, Political Correspondent, Flowers, Christopher Thomas, South Asia Correspondent, Edward Gorman Ireland Correspondent, Richard Ford, Home Correspondent, Jean Henderson, Bill Frost, Tim Judah, Sheila Gunn, Political Correspondent, Bernard Kaukas, Peter Riddell, Political Editor, P W R Robeson, Angela MacKay, Matt Wolf, Peter Judge, D. R. Pinyoun, L. E. J. Roberts, James Bone, Melinda Wittstock, Media Correspondent, Richard Streeton, Kevin Eason, Motoring Correspondent, Debra Isaac, Sean Hallahan, Matthew D'ancona, Education Correspondent, J. K., Kevin Eason, S. T. Eason, Ruth Evans, Director, Gerald Davies, Philip Bassett Industrial Editor, Martin Fletcher, Mitchell Platts, Golf Correspondent, Andrew Longmore Tennis Correspondent, Jane Bird, Dessa Trevisan, Tim Judah, Bruce Clark, J. Triseliotis, Ian Guyster, Patricia Tehan, Malcolm Green, Director, James Bone and Sam Kiley, Brian Hulme, Retired Chairman, Raymond Keene Chess Correspondent, Louise Taylor, Matthew May, Ruth Gledhill Religion Correspondent, Richard Ford Home Correspondent, Godfrey Dodds, Alan Hamilton, Robin Young, John Hart, Michael Clark, Philip Robinson, John Young, David Guest, John Percival, Peter Barnard, Michael Binyon Diplomatic Editor, Richard Cork, Adam Lebor, J. J. R. Dirks, Anatole Kaletsky, Economics Editor, Philip Webster, Chief Political Correspondent, Jill Sherman and Nicholas Wood, David Powell Athletics Correspondent, Jonathan Prynn, John Russell Taylor, Raymond Keene, Chess Correspondent, Craig Brown, Frances Gibb, Legal Correspondent, Ian Kelcey, Anthony Swainson, Director, Alice Thomson, Dennis Beard, Barry Pickthall, Sally Tomlinson, Richard Evans Miami, Rodney Hobson, Michael Dynes, Transport Correspondent, B. N., Pamela Wightwick, Robin Stacey, Joanna Pitman, David Young, John Goodbody, Edward Gorman and George Brock, James Pringle, Srikumar Sen Boxing Correspondent, Matthew Parris, Christopher Bishop, Caitlin Moran, Walter Gammie, Peter Riddell, Ben MacIntyre, Benedict Nightingale and Jeremy Kingston, Chris Dighton, Nadine Meisner, David Crawford, Graham Mather, Melinda Wittstock, Simon Jenkins, Tim Jones, William Cash, Martin Waller, David Sinclair, Michael Horsnell, Nigel Hawkes Science Editor, Frances Gibb Legal Correspondent, Hugh Thompson, David Penfold, Veronica Heath, Anne McElvoy, Alan Jackson, Colin Campbell, David Hands, Rugby Correspondent, Christopher Irvine,
... Redland girls to pioneer rugby Schools Sport The clenbuterol loophole John Goodbody examines the curious background to ...
1992 - Gale Group | TDA
... with the centrally active beta-2 adrenergic agonist clenbuterol reduced response rate and increased reinforcement rate of ... treatment, rapid tolerance developed to this effect of clenbuterol. Redetermination of the dose-response function for clenbuterol, following 2 weeks of repeated daily administration, showed that clenbuterol no longer affected DRL behavior at doses up to 3 mg/kg. Interestingly, tolerance developed to clenbuterol even when it was administered after each daily ... appreciable manner, to the development of tolerance to clenbuterol, and that neuropharmacological changes were sufficient for tolerance ...
Tópico(s): Neuropeptides and Animal Physiology
1990 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Philip Webster and Sheila Gunn, Stephen Bush, Andrew Robathan, Kenneth Minogue, Jon Ashworth, Roger Boyes, East Europe Correspondent and Michael Binyon, Diplomatic Editor, David Adams, Nicholas Wood, Political Correspondent, Edward Gorman Ireland Correspondent, Ross Tieman, Industrial Correspondent, Karl Knight, Philip Howard, Sarah Mower, Vinson, Jeremy Kingston, Angela Browning, Noel Goodwin, Carol Leonard, Richard Streeton, Alan Duncan, Nicholas Wood and Jill Sherman, Basil Feldman (Chairman), Tony Patrick, Roddy Forsyth, Peter Riddell Political Editor, Gerald Davies, Thunderer, Martin Fletcher, Michael Dynes Transport Correspondent, Ralph Harris, Brian Hindley, Patricia Tehan, John Browne, Caroline Sullivan, Roger Graef, Louise Taylor, Rachel Kelly, Lionel Bloch, Liam Fox, Nigel Waterson, Libby Purves, Jeremy Laurance Health Services Correspondent, Philip Webster, Chief Political Correspondent, and George Brock, René Riley-Adams, Alan Hamilton, Robin Young, Nigel Evans, John Mason (Chairman), Charles Bremner, Joseph Connolly, Neil Bennett Banking Correspondent, Philip Bassett, Industrial Editor, Michael Binyon Diplomatic Editor, Peter Lewis, Derwent May, Kate Muir, Pete Challis (Chair), David Faber, Wolfgang M?nchau, Russell Kempson, Richard Cork, Martin Fletcher and Kate Muir, Lindsay Cook, Martin Hoyle, Nicholas Harling, Phil Gallie, David Miller, Alan Toogood, Horticulture Correspondent, David Toop, R. D. A. Pick, Lindsay Cook, Money Editor, Robert McLean, Raymond Keene, Chess Correspondent, Matthew D'ancona, Selina Scott, P. A. D. Dole-Thomas, Craig Brown, Frances Gibb, Legal Correspondent, Diana Allen, Alan Ryan, David Willetts, Nick Hawkins, David Lidington, Geoffrey Clifton-Brown, Barry Pickthall, Arthur Cowgill (Director), Ian Ross, Bryan Appleyard, Martin Holmes, Sheila Vince, Jamie Dettmer, John Sykes, Swaythling, Joanna Pitman, John Goodbody, Mandarin, Colin Narbrough, Economics Correspondent, Charles Hendry, Matthew Parris, Graham Searjeant Financial Editor, G. B. Miller, David Wolfson, Richard Beeston and Tim Judah, Keith Kemp, Michael Austin, Ben MacIntyre, J. E. Garfitt, Michael Phillips, Nadine Meisner, Simon Jenkins, Philip Pangalos, Michael Binyon, Diplomatic Editor, Tim Jones, Anthony Morris, Arthur Leathley, Anne McElvoy, Martin Waller Deputy City Editor, Alan Jackson, Matthew Bond, Anthony Howard, Peter Willsher, Keith Joseph, H. D. Berman, David Hands, Rugby Correspondent, Roy Thomason, Andrew Longmore, Tennis Correspondent, Colin McQuillan, B. C. Roberts, Sam Kiley, Africa Correspondent, Stuart Jones, Football Correspondent, Wolfgan M?nchau, European Business Correspondent,
... Squash Yesterday's Results Shot putter admits taking clenbuterol during AAAs event Drugs in Sport TCCB ruling ...
1992 - Gale Group | TDA
P. E. V. Williams, Leopoldo Pagliani, G. M. Innes, K. Pennie, C. I. Harris, Paul H. Garthwaite,
... to determine the effects of a β-agonist (clenbuterol) on body composition and energy retention. Four calves ... calves per group) were given milk replacer plus clenbuterol(O.1 and 1.0 mg clenbuterol/kg milk replacer equivalent to approximately 2 and ... over the weight range 146–177 kg. 2. Clenbuterol had no significant effect on dry matter (DM) ... retention was increased over the experimental period in clenbuterol-treated calves, although the effect only achieved significance ... 110 kg live weight ( P < 0.05). 3. Clenbuterol (20 μg/kg body-weight) increased estimated mean ...
Tópico(s): Pesticide Residue Analysis and Safety
1987 - Cambridge University Press | British Journal Of Nutrition
Alice Thomson Political Staff, Phil Yates, Liz Dolan, Lynne Greenwood, Paul Heiney, Gillian Bowditch Scotland Correspondent, Donald Clarke, Des Keenan, John Vincent, Rob Hughes, Rose Wild, Simon Barnes, Rob Hughes, football correspondent, Jane MacQuitty, Alison Roberts Arts Reporter, Jill Sherman Political Correspondent, Ronald Faux, David Rhys Jones, John Diamond, Anne McElvoy, Moscow Correspondent, Philip Howard, Hilary Finch, Cyril Cunningham, Ian Murray, Alexandra Frean Media Correspondent, Clive Davis, Albert Dormer, Carl Mortished, Steven Meisel, Colin Narbrough, World Trade Correspondent, Francesca Greenoak, Martin Fletcher, Ruth Gledhill, Religion Correspondent, Stuart Jones, Alan Lorimer, Peter Ball, Martin Flanagan, Ruth Gledhill, H. G. Jerrard, J. Byron-Archer, Nigel Williams, Keith Pike and Peter Ball, Alison Roberts, Arts Reporter, Heather Newman, Lia Williams, Michael Evans, Defence Correspondent, Gerald Isaaman, (Editor), Robin Young, Louise Hidalgo, Michael Clark, Clive Anderson, Philip Robinson, Mel Batty's, Keith Pike, Kevin Eason Motoring Correspondent, David Hands, Charles Bremner, Philip Bassett, Industrial Editor, Derwent May, Susan Gilchrist, Margaret Dibben, James Hepburn, Sydney Friskin, R. D. R. Probert, Jill Insley, John Wijngaards, John Higgins, Charles Jennings, David Powell Athletics Correspondent, Darrel Rees, Melvyn Marckus City Editor, Raymond Keene, Jonathan Prynn, Peter Davalle, Frances Gibb, Legal Correspondent, Richard Southwood, Peter Bryan, John Vincent and Marianne Curphey, Robert Payne, Richard Evans, Moy McCrory, Alice Thomson, Harry Greenway, Barry Pickthall, Roger Boyes, Nigel Hawkes, Science Editor, Raymond Keene and Daniel Johnson, Ian Wisniewski, Barry Shooter, Derek Richards, Philip Webster, Political Editor, John Sherlock, David Hands Rugby Correspondent, Julian Muscat, Nicholas Wood, Chief Political Correspondent, Desmond Hartley, Christopher Thomas, John Goodbody, Jane Bidder, Ross Tieman Industrial Correspondent, Coomi Kapoor and Robi Dutta, Srikumar Sen Boxing Correspondent, Matthew Parris, Louisa Young, Richard Evans Racing Correspondent, Ronald Millar, Frank Jeffery, S. R. L. Green, Ellen Cranitch, Christine Wheeler, Arthur H. Doe, Ben MacIntyre, Ian Brodie, D. Cowe, Stephanie Trotter, Simon Jenkins, Hattie Ellis, Stephen Pettitt, Nigel Hawkes Science Editor, Tom White, Chief Executive, Jonathan Meades, Ted Cunningham, Anne McElvoy, Andrew Morris, Lindsay Cook Deputy Business Editor, Susan MacDonald, Fiona Beckett, Andrew Finkel, John Phillips, Matthew Bond, Ross Tieman, Rosanna Greenstreet, Conal Gregory, J. Joseph, Edward Marriott, Christopher Irvine, Peter Gray (Director),
... the Press Growth drug found in supermarket pate Clenbuterol, taken secretly by athletes, is also used to ...
1993 - Gale Group | TDA
Nancy J. Rothwell, Michael J. Stock, D. Sudera,
Rats injected with the β 2 ‐adrenoceptor agonist clenbuterol (2 mg kg −1 per day) for 18 ... fold) and brown (3 fold) adipose tissue of clenbuterol‐treated rats but was unaffected in kidney, brain ... about 80% in skeletal muscle. Acute injection of clenbuterol one hour before measuring blood flow, increased blood ... increased more in the rats treated chronically with clenbuterol (6 fold increase) than in control rats (2 ... significantly lower in the rats treated chronically with clenbuterol. Skeletal muscle β‐adrenoceptor density and subtype were ...
Tópico(s): Hormonal and reproductive studies
1987 - Wiley | British Journal of Pharmacology
Gregory A. Ordway, James M. O’Donnell, Alan Frazer,
... administration of the centrally acting beta adrenoceptor agonist, clenbuterol, to rats reduced the ability of isoproterenol to ... of remaining cerebellar beta adrenoceptors were altered after clenbuterol treatment. The clenbuterol-induced reduction in the density of beta adrenoceptors ... in cerebral cortex. Comparison of the ability of clenbuterol to that of isoproterenol to increase levels of ... slices of cerebral cortex or cerebellum showed that clenbuterol is a weakly potent agonist in both brain ... adrenoceptor antagonist, ICI 89,406. In contrast, the clenbuterol-induced increase in cortical cAMP was unchanged by ...
Tópico(s): Neuropeptides and Animal Physiology
1987 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
P. E. V. Williams, Leopoldo Pagliani, G. M. Innes,
... study the action of a β-adrenergic agonist (clenbuterol). At seventeen days of age calves were allocated ... calves given 0.1 or 1.0 mg clenbuterol kg−1 milk replacer DM). Three digestibility/nitrogen ... 150 and 170 kg live weight. Treatment with clenbuterol doubled heart rate for approximately 24 and 72 ... 0.1 and 1.0 mg kg−1 clenbuterol, respectively, thereafter heart rate was normal. N retention ... of N intake was increased by treatment with clenbuterol, but differences were only significant in calves weighing ...
Tópico(s): Pesticide Residue Analysis and Safety
1986 - Elsevier BV | Livestock Production Science
P A MacLennan, R. H. T. Edwards,
1. A single subcutaneous injection of clenbuterol hydrochloride (0.125 mg/kg body wt.) to female Wistar rats produced a rapid increase in muscle cyclic AMP and lactate concentrations ... propranolol (12.5 mg/kg) 15 min before clenbuterol administration. 2. When this dose of clenbuterol was injected twice daily, the changes in muscle ... and muscle protein synthesis rate (ks). When the clenbuterol injections were preceded by propranolol injections (12.5 ... synthetic diet (PW3) supplemented with 2 mg of clenbuterol/kg of diet for 7 days, the muscle ...
Tópico(s): Muscle metabolism and nutrition
1989 - Portland Press | Biochemical Journal
Matthew Miller, D. K. Garcia, Michael Coleman, P. A. Ekeren, D. K. Lunt, Katrin Wagner, Mauro Procknor, Thomas H. Welsh, Stephen B. Smith,
... was conducted to determine the effects of feeding clenbuterol on adipose tissue and longissimus muscle growth in ... 14 heifers were fed either a sucrose-based, clenbuterol supplement or a placebo in which the clenbuterol had been omitted. The heifers were slaughtered in ... at slaughter. Changes in carcass characteristics elicited by clenbuterol were similar to those reported by others for ... tissue in the adipose tissue depots of the clenbuterol-fed heifers. Clenbuterol decreased lipogenic enzyme activities, fatty ...
Tópico(s): Muscle metabolism and nutrition
1988 - Oxford University Press | Journal of Animal Science
Jen-Chih Chang, Wen‐Chuan Lee, Yu‐Tse Wu, Tung‐Hu Tsai,
Clenbuterol is clinically used as a bronchodilator, but it is also illegally used to increase lean meat ... To investigate the muscle distribution of protein-unbound clenbuterol, a microdialysis technique coupled to liquid chromatography system was applied to simultaneously monitor clenbuterol in rat blood and muscle. Two microdialysis probes ... hind leg muscle of rat for sampling after clenbuterol administration (10 mg/kg) through the femoral vein. Dialysate samples of clenbuterol were separated by a reversed-phase column (250 ...
Tópico(s): Veterinary Pharmacology and Anesthesia
2009 - Elsevier BV | International Journal of Pharmaceutics
Robert A. Ngala, Jacqueline O’Dowd, Steven J. Wang, Claire J. Stocker, Michael A. Cawthorne, Jonathan R.S. Arch,
... previous work, 10 pM BRL37344 and 10 pM clenbuterol stimulated glucose uptake in mouse soleus muscle. Ten nM BRL37344 also stimulated uptake but 100 nM clenbuterol inhibited uptake. Antagonist studies suggested that the opposite effects of 10 nM BRL37344 and 100 nM clenbuterol are mediated by the beta(2)-adrenoceptor. BRL37344 and clenbuterol have been studied in muscles that lack beta( ... Concentration-response relationships were similar for BRL37344 and clenbuterol in normal muscle and muscle lacking beta(3)- ...
Tópico(s): Receptor Mechanisms and Signaling
2009 - Wiley | British Journal of Pharmacology
Anna Alonen, Minna Gartman, Olli Aitio, Moshe Finel, Jari Yli‐Kauhaluoma, Risto Kostiainen,
Two clenbuterol O-glucuronide diastereomers were synthesized by the Koenigs–Knorr reaction. Structures and glucuronidation sites of the glucuronides ... standard compounds in studies of stereoselective glucuronidation of clenbuterol with liver microsomes from different species and with ... and enzymatic reactions produced only O-glucuronides of clenbuterol, although on the basis of the chemical structure ... the aglycone, both O- and N-glucuronides of clenbuterol could be formed. Differences in the production of ...
Tópico(s): Analytical Chemistry and Chromatography
2009 - Elsevier BV | European Journal of Pharmaceutical Sciences
A. C. Dilger, S.R. Gabriel, L.W. Kutzler, F. K. McKeith, J. Killefer,
... the myostatin (Mstn) null mutation and treatment with clenbuterol both increase muscle growth and decrease fat mass. ... to determine whether mechanistic overlap exists by administering clenbuterol to Mstn null mice. Male Mstn null and ... either 0 (control) or 20 p.p.m. clenbuterol in tap water free choice for 14 days. ... carcasses of Mstn null mice. Similarly, treatment with clenbuterol resulted in increased body and empty carcass weight, ... protein content of empty carcasses was increased with clenbuterol treatment. A significant interaction of genotype and clenbuterol ...
Tópico(s): Muscle metabolism and nutrition
2009 - Elsevier BV | animal
... calves were used to study the pharmacokinetics of clenbuterol after an effective anabolic dosage of 5 μg/ ... given twice daily for 3 wk. Analyses of clenbuterol concentrations in different tissues was done by enzyme ... more after 3.5 or 14 d of clenbuterol withdrawal. The rate of clenbuterol elimination was dependent on time and tissue. Clenbuterol concentrations in the lung dropped from a mean ... after 14 d, whereas in the liver the clenbuterol concentrations decreased from 46 ng/g to .6 ... that different compartments contribute to the elimination of clenbuterol; therefore, concentrations in urine do not follow first ...
Tópico(s): Receptor Mechanisms and Signaling
1991 - Oxford University Press | Journal of Animal Science
William J. Carter, An Q. Dang, Fred H. Faas, Mary Lynch,
... muscle in elderly subjects with muscle wasting disorders. Clenbuterol, a β2-adrenergic agonist, dramatically increases skeletal muscle ... the protein anabolic and fat catabolic effects of clenbuterol have not been studied in senescent animals. To ... examined its effects in young and old rats. Clenbuterol was administered by implanted osmotic minipumps to Fischer- ... and carcass protein and fat content were determined. Clenbuterol treatment increased the weight of skeletal muscles 22% ... to 25% in 23-month-old animals. Likewise, clenbuterol increased carcass protein content 19% in 3-month- ...
Tópico(s): Adipose Tissue and Metabolism
1991 - Elsevier BV | Metabolism
H. Hooijerink, R. Schilt, Willem Haasnoot, Dirk Courtheijn,
A method for the determination of clenbuterol in calf urine is described. After a simple two-step sample pretreatment, involving an Extrelut-3 column and a solid-phase extraction column (C2), the separation of clenbuterol from interfering compounds present in urine samples was ... ng ml-1 and the mean recovery of clenbuterol spiked at 10 ng ml-1 level was ... in which a calf received orally 4 micrograms clenbuterol.HCl per kilogram body weight twice a day ( ... application) for 5 days, the highest concentration of clenbuterol found in urine was 73 ng ml-1. ...
Tópico(s): Advanced Sensor Technologies Research
1991 - Elsevier BV | Journal of Pharmaceutical and Biomedical Analysis
... responses of dwarf mice to dietary administration of clenbuterol (3 mg/kg diet), daily injections of growth ... 8 of treatment. Growth hormone, with or without clenbuterol, induced an increase in body-weight growth and tail length growth; clenbuterol alone did not affect body-weight or tail length. Both growth hormone and clenbuterol reduced the percentage of whole-body fat and ... greater in response to growth hormone than to clenbuterol. Clenbuterol specifically induced growth of muscle, with a decrease ...
Tópico(s): Adipose Tissue and Metabolism
1991 - Cambridge University Press | British Journal Of Nutrition
J. Buyse, Eddy Decuypere, G. Huyghebaert, Marc Herremans,
In the present experiment, clenbuterol was supplemented (.42 ppm) from Day 1 or from 2 or 4 wk of age until slaughter age (6 wk). ... There were no consistent or cumulative effects of clenbuterol feeding on growth and feed efficiency. Clenbuterol feeding from Day 1, but not later, depressed ... of breast meat (without skin), was reduced by clenbuterol feeding. No consistent effects of clenbuterol supplementation on plasma thyroid hormones, growth hormone, insulin- ... VLDL) concentrations were depressed in male broilers fed clenbuterol for 6 wk, but the plasma triglyceride level ...
Tópico(s): Animal Nutrition and Physiology
1991 - Elsevier BV | Poultry Science
Yasuharu Oishi, K Imoto, Takehiro Ogata, Keisuke Taniguchi, H. Matsumoto, Roland R. Roy,
Clenbuterol, a beta2-agonist, administration results in hypertrophy of fast fibres and an increase in the fast ... the phenotypic response at the single fibre level. Clenbuterol was added to the drinking water (30 mg ... muscle of control (10 rats; 555 fibres) and clenbuterol-treated (10 rats; 577 fibres) were dissected and ... weights were 9, 24, and 27% higher in clenbuterol-treated than control rats. The mean cross-sectional ... approximately 64 and approximately 74% larger in the clenbuterol-treated than control rats, whereas the size of ...
Tópico(s): Cardiovascular Effects of Exercise
2002 - Wiley | Acta Physiologica Scandinavica
H. Cavalié, G. Lac, Patrice Lebecque, Brigitte Chanteranne, M. J. Davicco, J.P. Barlet,
... that the selective beta(2)-adrenergic receptor agonist clenbuterol affects bone metabolism in growing 3-mo-old ... isometric force, strength-training exercise program plus oral clenbuterol (2 mg x kg body wt(-1) x ... for 5 days each week, exercise program without clenbuterol 5 days each week, no exercise program plus oral clenbuterol (2 mg x kg(-1) x day(-1)) ... 5 days each week, or no exercise without clenbuterol 5 days each week. At the end of ... exercise and decreased further in rats treated with clenbuterol. Lean mass was increased in clenbuterol-treated animals. ...
Tópico(s): Hormonal and reproductive studies
2002 - American Physiological Society | Journal of Applied Physiology
Getu Abraham, Otto‐Erich Brodde, F. R. Ungemach,
... horses, the effects of the β 2 ‐agonist clenbuterol and the glucocorticoid dexamethasone on the lymphocyte β ... responses to 10 μmol/l (‐)‐isoprenaline) were studied. Clenbuterol treatment, 2 × 0.8 μg/kg/day i. ... response to (‐)‐isoprenaline was reduced. After withdrawal of clenbuterol, β 2 ‐adrenoceptor density and responsiveness gradually increased, ... after 4 days. The effects of dexamethasone on clenbuterol‐induced desensitisation were further investigated. Administration of dexamethasone ( ... day, i.v. for 5 days) immediately after clenbuterol withdrawal accelerated β 2 ‐adrenoceptor recovery: only 24 ...
Tópico(s): Neuropeptides and Animal Physiology
2002 - Wiley | Equine Veterinary Journal
Jean‐Christophe Peter, Pierre Eftekhari, Philippe Billiald, Gerd Wallukat, Johan Hoebeke,
... the chronotropic activity induced by the β2-agonist clenbuterol. They also decreased the in vivo heart beating ... the chronotropic activity induced by the β2-agonist clenbuterol. They also decreased the in vivo heart beating ... beating rate of neonatal rat cardiomyocytes stimulated by clenbuterol (a specific β2-agonist) (Fig. 4). The basal ... rate of the cardiomyocytes as well as the clenbuterol dose-response curve were decreased. In view of the fact that the clenbuterol dose-response curve was not shifted to the ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2003 - Elsevier BV | Journal of Biological Chemistry
Alan Hayes, David A. Williams,
... long‐term treatment with the powerful anabolic agent clenbuterol has beneficial effects on dystrophin‐deficient skeletal muscle ... C57BL/10) and dystrophic ( mdx ) mice were administered clenbuterol (2 mg/kg per day) for 15 weeks. ... lower ( P <0.001) in mdx mice. 4. Clenbuterol increased the lean muscle mass in both normal ( ... 001) and soleus ( P <0.01) muscles following clenbuterol administration, supported by fibre‐type transitions towards fast‐ ... P <0.01) mice were increased significantly following clenbuterol treatment. No changes in the absolute or relative ...
Tópico(s): Muscle metabolism and nutrition
1994 - Wiley | Clinical and Experimental Pharmacology and Physiology
María C. Estrada-Montoya, Aarón F. González‐Córdova, G. Torrescano, Juan Pedro Camou, Belinda Vallejo‐Córdoba,
... uses preliminary screening methods for the determination of clenbuterol, but also uses confirmatory methods such as MS- ... this work was to monitor the presence of clenbuterol residues in bovine meat muscle collected from the ... analyzed by the ELISA test, 6 (12%) presented clenbuterol residues from 3.06 to 6.12 μg/ ... μg/kg. The six samples with the highest clenbuterol residues were subjected to GC-MS-MS for confirmation. The results showed that clenbuterol was illegally used as a bovine growth promoter. ... determinar y confirmar la presencia de residuos de clenbuterol en carne de bovino comercializada en el noroeste ...
Tópico(s): Veterinary Pharmacology and Anesthesia
2008 - Taylor & Francis | Ciencia y Tecnologia Alimentaria
Robert A. Ngala, Jacqueline O’Dowd, S J Wang, Ajit Agarwal, Claire J. Stocker, Michael A. Cawthorne, J R Arch,
... in C2C12 cells.10 pM BRL37344, 10 pM clenbuterol and 100 pM salbutamol stimulated 2-deoxyglucose uptake ... or IC3118551, or 1 microM SR59230A; that of clenbuterol was prevented by ICI118551 but not atenolol. 10 ... BRL37344 stimulated 2-deoxyglucose uptake, whereas 100 nM clenbuterol and salbutamol inhibited uptake. These effects were blocked ... RT-PCR. 10 nM BRL37344 and 10 pM clenbuterol stimulated muscle palmitate oxidation. In the presence of ... stimulated 2-deoxyglucose uptake and the effect of clenbuterol was not significant.Stimulation of glucose uptake by ...
Tópico(s): Adipose Tissue and Metabolism
2008 - Wiley | British Journal of Pharmacology
Shogo Sato, Sachiko Nomura, Fuuun Kawano, Jun Tanihata, Kaoru Tachiyashiki, Kazuhiko Imaizumi,
The β2-agonist clenbuterol [4-amino-α(t-butyl-amino)methyl-3,5-dichlorobenzyl alcohol] is used as a non-steroidal anabolic drug for sports doping. The effects of clenbuterol on the transcriptional process and mRNA stability of ... still unknown. Therefore, we investigated the effects of clenbuterol on β1- and β2-AR mRNA expressions of ... male Sprague Dawley rats were divided into the clenbuterol-administered group and control group. The administration (dose = ... mg/kg body weight/day, s.c.) of clenbuterol was maintained for 10 days. The administration of ...
Tópico(s): Exercise and Physiological Responses
2008 - Elsevier BV | Journal of Pharmacological Sciences
Gayathri Kamalakkannan, Christopher M. Petrilli, Isaac George, John J. LaManca, Brooke T. McLaughlin, Elizabeth Shane, Donna Mancini, Simon Maybaum,
Clenbuterol, a β2-agonist with potent anabolic properties, has been shown to improve skeletal muscle function in ... randomized controlled study, we investigated the effect of clenbuterol on skeletal muscle function, cardiac function, and exercise capacity in patients with chronic heart failure. Clenbuterol was well tolerated and led to a significant ... fat ratio. Maximal strength increased significantly with both clenbuterol (27%) and placebo (14%); however, endurance and exercise duration decreased after clenbuterol. Prior data support combining exercise training with clenbuterol ...
Tópico(s): Cardiovascular Effects of Exercise
2008 - Elsevier BV | The Journal of Heart and Lung Transplantation