Masatoshi Ito, Tomoko Miyajima, Tatsuya Fujii, Takehiko Okuno,
We examined the antiepileptic effect of cloxazolam on seizures in 23 patients with intractable epilepsy. Most of the patients had central nervous system complications, as well as frequent seizures, and were being treated with polypharmacy. Cloxazolam was administered 1 to 5 mg/day (0. ... epilepsy manifested a good response. The spectrum of cloxazolam as an antiepileptic was wide. Effective doses were ... desmethyldiazepam were 12.3-115.1 ng/mL. Cloxazolam may be an effective and safe antiepileptic for ...
Tópico(s): Drug Transport and Resistance Mechanisms
2004 - Elsevier BV | Pediatric Neurology
Hisashi Murata, KATSUMI KOUGO, AKIRA YASUMURA, Eiichi Nakajima, HIDEYO SHINDO,
The distribution, excretion and biotransformation of 14C-cloxazolam were studied in rats and mice. The tissue concentration reached the maximum at about 1 and 3 hr after oral administration to rats ... urine and feces after oral administration of 14C-cloxazolam. Among them, eight metabolites including 7-chloro-2, ...
Tópico(s): Neuroscience and Neuropharmacology Research
1973 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Margot Albus, S. Ståhl, F. Müller‐Spahn, Rolf R. Engel,
... A = 4 mg Pindolol, B = 1.5 mg Cloxazolam, C = Placebo, D = 4 mg Pindolol + 1.5 mg Cloxazolam. Subjects underwent four stress situations: Counting, noise, mental ... heart rate, mainly during mental arithmetic and ergometry, Cloxazolam reduced electrodermal activity, mainly during noise. It can ...
Tópico(s): Neural and Behavioral Psychology Studies
1986 - Elsevier BV | Biological Psychology
The clinical activity and the tolerance of cloxazolam (4 mg/day), a new anxiolytic benzodiazepine, was compared to bromazepam (12 mg/day) in two parallel groups of 427 and 410 psychiatric ... benzodiazepines, visual analogue scales showed significant superiority of cloxazolam over bromazepam on psychological anxiety, somatic anxiety, depressed ... sedative effect, but less muscle-relaxant effect with cloxazolam than with bromazepam. The better efficacy and tolerance of cloxazolam compared to bromazepam was confirmed by the global ...
Tópico(s): Treatment of Major Depression
1990 - Karger Publishers | Neuropsychobiology
Produção Nacional
Revisado por pares
Diogo Oliveira‐Silva, Celso Henrique de Oliveira, Gustavo Duarte Mendes, Paulo Alexandre Rebelo Galvinas, Rafael E. Barrientos‐Astigarraga, Gilberto De Nucci,
... chlordesmethyldiazepam (CDDZ or delorazepam), the active metabolite of cloxazolam, in human plasma. In the analytical assay, bromazepam ( ... and it was applied to the bioequivalence study (Cloxazolam—test, Eurofarma Lab. Ltda and Olcadil®— reference, Novartis ...
Tópico(s): Forensic Toxicology and Drug Analysis
2009 - Wiley | Biomedical Chromatography
Iwao Nakatsuka, Hiroshi Shimizu, Yukio Asami, Terufumi Katoh, Akira Hirose, Akira Yoshitake,
... in vivo activities. On the contrary, medazepam and cloxazolam showed extremely low affinities and oxazolam showed no ... strongly suggest that in the case of medazepam, cloxazolam and oxazolam, their metabolites may bind to receptor ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
1985 - Elsevier BV | Life Sciences
Produção Nacional
Revisado por pares
Camila Cristina Almeida de Paula, Marina Jurisch, Evandro Piccin, Rodinei Augusti,
... 5 distinct benzodiazepines (diazepam, alprazolam, bromazepam, clonazepam, and cloxazolam) simulating a drug-facilitated crime occurrence. The direct ... beer as matrix, diazepam as target analyte and cloxazolam as an internal standard. Figures of merit (linearity, ...
Tópico(s): Forensic Toxicology and Drug Analysis
2018 - Wiley | Drug Testing and Analysis
Wolfram Boucsein, Gitta Wendt-Suhl,
... an orally administered single dose of 3 mg cloxazolam as compared to 5 mg diazepam and a ...
Tópico(s): Anesthesia and Sedative Agents
1982 - Thieme Medical Publishers (Germany) | Pharmacopsychiatry
Yukihisa Kurono, Kinya Kamiya, T Kuwayama, Yasuhiro Jinno, TAMOTSU YASHIRO, KEN IKEDA,
... ring-opening and ring-closing reactions of mexazolam, cloxazolam, haloxazolam, and flutazolam were investigated by a pH- ... its 2'-chlorine deficient analog (3-methyl compound), cloxazolam, haloxazolam, and flutazolam were determined according to the ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
1987 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
... Haloperidol was discontinued and 2 mg/day of cloxazolam was prescribed. In Japan, cloxazolam is prescribed for its antianxiety effects, similar to ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2010 - American Psychiatric Association Publishing | Journal of Neuropsychiatry
Nobusuke Kimura, Tatsuya Fujii, Tomoko Miyajima, Tomohiro Kumada, Takayasu Mikuni, Masatoshi Ito,
Cloxazolam has been used mainly as an anxiolytic agent. The present study was designed to evaluate the effectiveness of cloxazolam as an add-on antiepileptic drug in patients ... 32 patients with intractable epilepsy were treated with cloxazolam: 13 with generalized epilepsy, 15 with focal epilepsy, ... 2 years after reaching a maintenance dose. With cloxazolam, seizure frequency was reduced by ≥ 50% in 19/ ... term therapy. Two became seizure free throughout the cloxazolam therapy. During initial therapy, 8/32 patients (25%) ...
Tópico(s): Drug Transport and Resistance Mechanisms
2010 - Elsevier BV | Pediatric Neurology
Toshiharu Kamioka, Isao Nakayama, Seigo Akiyama, Hiromu Takagi,
Tópico(s): Neuroendocrine regulation and behavior
1977 - Springer Science+Business Media | Psychopharmacology
H Sawada, A Hara, S Asano, Y Matsumoto,
... and identify seven benzodiazepine derivatives--diazepam, chlorodiazepoxide, nitrazepam, cloxazolam, oxazolam, oxazepam, and medazepam--and their metabolites in ...
Tópico(s): Epilepsy research and treatment
1976 - American Association for Clinical Chemistry | Clinical Chemistry
T Kuwayama, Yukihisa Kurono, TSUYUKO MURAMATSU, TAMOTSU YASHIRO, Ken‐ichi Ikeda,
... the hydrolysis, the rate constants of oxazolam and cloxazolam in acidic solution were also determined.
Tópico(s): Analytical Chemistry and Chromatography
1986 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
Fabriciano Rodríguez, Rosa M. Jiménez, Rosa M. Alonso,
Tópico(s): Analytical Chemistry and Chromatography
1989 - Springer Nature | Fresenius Zeitschrift für Analytische Chemie
Noriyuki Usami, Tomohiro Yamamoto, Syunichi Shintani, Yu Higaki, Shuhei Ishikura, Yoshihiro Patagiri, Akira Hara,
... isoenzymes noncompetitively with respect to the substrate. Although cloxazolam was a potent and specific inhibitor of AKR1C3, ...
Tópico(s): Hormonal Regulation and Hypertension
2002 - Pharmaceutical Society of Japan | Biological and Pharmaceutical Bulletin
Ruth Verplaetse, Eva Cuypers, Jan Tytgat,
... alprazolam, bromazepam, brotizolam, chlordiazepoxide, chlornordiazepam, clobazam, clonazepam, clotiazepam, cloxazolam, diazepam, ethylloflazepate, flunitrazepam, flurazepam, loprazolam, lorazepam, lormetazepam, midazolam, ...
Tópico(s): Mass Spectrometry Techniques and Applications
2012 - Elsevier BV | Journal of Chromatography A
Bethan Richards, Samuel Whittle, Rachelle Buchbinder,
... the antispasmodic benzodiazepines (alprazolam, bromazepam, chlordiazepoxide,cinolazepam, clonazepam, cloxazolam, clorazepate, diazepam, estazolam, flunitrazepam, flurazepam, flutoprazepam, halazepam, ketazolam, ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2012 - Elsevier BV | Cochrane library
M. Laloup, María del Mar Ramírez Fernández, Gert De Boeck, Michelle Wood, Véronique Maes, Nele Samyn,
... 1 to 103.8%, except for one compound (cloxazolam in urine). Ion suppression was studied for all ...
Tópico(s): Analytical Methods in Pharmaceuticals
2005 - Oxford University Press | Journal of Analytical Toxicology
Edmund R. Volkerts, Joris C. Verster, Janet H. G. van Heuckelum, Dieuwke S. Veldhuijzen, Marinus N. Verbaten, Mona Darwish, Isabelle Paty, Alain Patat,
... alprazolam, bromazepam, brotizolam, chlordiazepoxide, chlornordiazepam, clobazam, clonazepam, clotiazepam, cloxazolam, diazepam, ethylloflazepate, flunitrazepam, flurazepam, loprazolam, lorazepam, lormetazepam, midazolam, ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2000 - Elsevier BV | European Neuropsychopharmacology
Hiroyuki Inoue, Yoshitaka Maeno, Mineo Iwasa, Ryoji Matoba, Masataka Nagao,
... the TIC with the exception of oxazolam to cloxazolam separation. The blank extract from whole blood gave ...
Tópico(s): Diet and metabolism studies
2000 - Elsevier BV | Forensic Science International
Kenji Otsubo, Hironori Seto, Koujiro Futagami, Ryozo Oishi,
... 0.1-0.4 micrograms/ml, except for cloxazolam and haloxazolam. The sensitivity was increased about ten- ...
Tópico(s): Neuroscience and Neuropharmacology Research
1995 - Elsevier BV | Journal of Chromatography B Biomedical Sciences and Applications
Marieke De Boeck, Sophie Missotten, Wim Dehaen, Jan Tytgat, Eva Cuypers,
... vast majority of compounds, except for brotizolam, chlordiazepoxide, cloxazolam, flunitrazepam, loprazolam, lorazepam and nitrazepam, which can only ...
Tópico(s): Analytical chemistry methods development
2016 - Elsevier BV | Forensic Science International
Maarten Degreef, Lore Vits, Eleanor M. Berry, Kristof E. Maudens, Alexander L.N. van Nuijs,
... only. In-sample stability issues were observed for cloxazolam, both at ambient temperature and during long-term ...
Tópico(s): Analytical chemistry methods development
2020 - Oxford University Press | Journal of Analytical Toxicology
Shouhei Miyazaki, Yoshio Fujita, H. Oikawa, Hideo Takekoshi, Hideaki Soya, Masato Ogata, Takahiko Fujikawa,
... test. As with ASH and the benzodiazepine anxiolytic cloxazolam (CLO), Mix treatment significantly increased locomotor activity in ...
Tópico(s): Calcium signaling and nucleotide metabolism
2020 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
1983 - UNIVERSIDADE FEDERAL DO RIO DE JANEIRO | Jornal Brasileiro de Psiquiatria
Kiyoshi ANDO, Tomoji Yanagita,
... kg，S．C，(diazepam)，8mg/kg，i．p，(cloxazolam)，32mg/kg，i.p.(chlordiazepoxide)であったが，oxazolamの場合は256mg/kg， ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
1974 - Japanese Pharmacological Society | Folia Pharmacologica Japonica
... Haloperidol was discontinued and 2 mg/day of cloxazolam was prescribed. In Japan, cloxazolam is prescribed for its antianxiety effects, similar to ...
Tópico(s): Epilepsy research and treatment
2010 - American Psychiatric Association Publishing | Journal of Neuropsychiatry
Tatsuya Hisada, Saori Gocho, Minehisa Gyota, Masashi Yamamoto, Koichiro Shima, Yasuhiro Gotô, Kenya Yoshida, M. Kusunose,
... effect of the administration of the anxiolytic agent cloxazolam (3 mg/day) together with standard antiemetic measures ( ... mg/m2).Subjects were randomly assigned to a cloxazolam group and placebo group by the minimization method, ... Nausea and vomiting were significantly inhibited in the cloxazolam group from Day 1 to Day 3 of ... protocol period was also significantly better in the cloxazolam group than in the placebo group.A stratified ... antiemetic effect showed that the inhibitory effect of cloxazolam with respect to delayed nausea was significantly higher ...
Tópico(s): Sympathectomy and Hyperhidrosis Treatments
2009 - Japanese Society of Pharmaceutical Health Care and Sciences | Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
A colorimetric determination for the toxicological analysis of cloxazolam, 10-chloro-11b-(2-chlorophenyl)-2, 3, 5, ... range of 0.2-8.0 μg/ml. Cloxazolam in body fluid and aqueous solution was determined ... method can be applied to the determination of cloxazolam and its metabolites in body fluid for routine ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
1975 - Pharmaceutical Society of Japan | Eisei kagaku