Yago Pico de Coaña, Maria Wolodarski, Isabel Poschke, Yuya Yoshimoto, Yuan Yang, Maria Nyström, Ulrika Edbäck, Søren Brage, Andreas Lundqvist, Giuseppe Masucci, Johan Hansson, Rolf Kiessling,
// Yago Pico de Coaña 1 , Maria Wolodarski 1, 2 , Isabel Poschke 3 , Yuya Yoshimoto 4 , Yuan Yang 1, 5 , Maria Nyström 1 , Ulrika ... Lauderdale, FL, USA Correspondence to: Yago Pico de Coaña, email: yagopico@gmail.com Keywords: melanoma, checkpoint blockade, ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2017 - Impact Journals LLC | Oncotarget
... consulta otorrinolaringologica foi detec-tado um tumor na coana esquerda. O exame endoscopico revelou um tumor unilateral ... O polipo encontrava-se pendente e solto na coana, ligado a sua base atraves de um fino ...
Tópico(s): Bone Tumor Diagnosis and Treatments
2014 - Elsevier BV | Brazilian Journal of Otorhinolaryngology
Vashisht Gopal Yennu Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies, Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo A. Ascierto, Carlo M. Croce, Rita Mancini, Stefani Spranger, Thomas F. Gajewski, Yangyang Wang, Soldano Ferrone, Claire Vanpouille‐Box, Erik Wennerberg, Karsten A. Pilones, Silvia C. Formenti, Sandra Demaria, Haidong Tang, Yang Wang, Yang‐Xin Fu, Reinhard Dummer, Igor Puzanov, Ahmad A. Tarhini, Joë-Marc Chauvin, Ornella Pagliano, Julien Fourcade, Zhaojun Sun, Hong Wang, Cindy Sander, John M. Kirkwood, Tseng-hui Timothy Chen, Mark Maurer, Alan J. Korman, Hassane M. Zarour, David F. Stroncek, Veronica Huber, Licia Rivoltini, Hong‐Ming Hu, Tilman T. Rau, Alessandro Lugli, Franck Pagès, Jorge Camarero, A Murgadella Sancho, Claudio Jommi, Yago Pico de Coaña, Maria Wolodarski, Yuya Yoshimoto, Giusy Gentilcore, Isabel Poschke, Giuseppe Masucci, Johan Hansson, Rolf Kiessling, Giosuè Scognamiglio, Francesco Sabbatino, Federica Zito Marino, Anna Maria Anniciello, Monica Cantile, Margherita Cerrone, Stefania Scala, Crescenzo D’Alterio, Angela Ianaro, Giuseppe Cirin, Giuseppina Liguori, Gerardo Bott, Paul B. Chapman, Caroline Robert, James Larkin, John B.A.G. Haanen, Antoni Ribas, David Hogg, Omid Hamid, Alessandro Testori, Paul Lorigan, Jeffrey A. Sosman, Keith T. Flaherty, Huibin Yue, Shelley Coleman, Ivor Caro, Axel Hauschild, Grant A. McArthur, Mario Sznol, Margaret K. Callahan, Harriet M. Kluger, Michael A. Postow, RuthAnn Gordan, Neil H. Segal, Naiyer A. Rizvi, Alexander M. Lesokhin, Michael B. Atkins, Matthew M. Burke, Amanda Ralabate, Angel L. Rivera, Stephanie Anne Kronenberg, Blessing Agunwamba, Mary Ruisi, Christine E. Horak, Joel Jiang, Jedd D. Wolchok, Paolo A. Ascierto, Gabriella Liszkay, Michele Maio, Mario Mandalà, Lev Demidov, Daniil Stoyakovskiy, L. Thomas, Luis de la Cruz‐Merino, Victoria Atkinson, Caroline Dutriaux, Claus Garbe, Matthew Wongchenko, Ilsung Chang, Daniel O. Koralek, Isabelle Rooney, Yibing Yan, Brigitte Dréno, Ryan J. Sullivan, Manish R. Patel, Stephen Hodi, Rodabe N. Amaria, Peter D. Boasberg, Jeffrey J. Wallin, Xian He, Edward Cha, Nicole Richie, Marcus Ballinger, David C. Smith, Todd M. Bauer, Jeffrey S. Wasser, Jason J. Luke, Ani Sarkis Balmanoukian, David R. Kaufman, Yufan Zhao, Janet Maleski, Lance Leopold, Tara C. Gangadhar, Georgina V. Long, Olivier Michielin, Ari M. Vanderwalde, Robert H.I. Andtbacka, Jonathan Cebon, Eugenio Fernández, Josep Malvehy, Anthony J. Olszanski, Christine K. Gause, Lisa Chen, Jeffrey Chou, F. Stephen Hodi, Benjamin Brady, Laurent Mortier, Jessica C. Hassel, Piotr Rutkowski, Catriona M. McNeil, Ewa Kalinka‐Warzocha, Célèste Lebbé, Lars Ny, Matías Chacón, Paola Queirolo, Carmen Loquai, Parneet Cheema, Alfonso Berrocal, Karmele Mujika Eizmendi, Gil Bar‐Sela, Christine E. Horak, Hélène Hardy, Jeffrey S. Weber, Jean‐Jacques Grob, Iván Márquez‐Rodas, Henrik Schmidt, Karen Briscoe, Jean‐François Baurain, Jedd D. Wolchok, Rosamaria Pinto, Simona De Summa, Vito Michele Garrisi, Sabino Strippoli, Amalia Azzariti, Gabriella Guida, Michele Guida, Stefania Tommasi, Nicolas Jacquelot, David Enot, Caroline Flament, Jonathan M. Pitt, Nadège Vimond, C Blattner, Takahiro Yamazaki, Maria-Paula Roberti, Marie Vétizou, Romain Daillère, Vichnou Poirier-Colame, Michaë la Semeraro, Anne Caignard, Craig L. Slingluff, Federica Sallusto, Sylvie Rusakiewicz, Benjamin Weide, Aurélien Marabelle, Holbrook E. Kohrt, Stéphane Dalle, Andréa Cavalcanti, Guido Kroemer, Anna Maria Di Giacomo, Michaele Maio, Phillip Wong, Jianda Yuan, Viktor Umansky, Alexander Eggermont, Laurence Zitvogel, Passarelli Anna, Tucci Marco, Stucci Stefania, Francesco Mannavola, Mariaelena Capone, Gabriele Madonna, Ascierto Paolo Antonio, Silvestris Franco, María Paula Roberti, David Enot, Michaëla Semeraro, Sarah Jégou, Camila Flores, Tseng-hui Timothy Chen, Byoung S. Kwon, Ana Carrizossa Anderson, Christophe Borg, F. Aubin, Maha Ayyoub, Anna Lisa De Presbiteris, Fabiola Gilda Cordaro, Rosa Camerlingo, Federica Fratangelo, Nicola Mozzillo, Giuseppe Pirozzi, Eduardo J. Patriarca, Emilia Caputo, Maria Letizia Motti, R. Terré Falcón, Roberta Miceli, Mariaelena Capone, Gabriele Madonna, Domenico Mallardo, M. Carrier, Elisabetta Panza, Paola De Cicco, Chiara Armogida, Giuseppe Ercolano, Gerardo Botti, Giuseppe Cirino, Angela Sandru, Miri Blank, Tímea Balatoni, Judit Olasz, Emil Farkas, András Szollár, Ákos Sávolt, Mária Gõdény, Orsolya Csuka, Szabolcs Horváth, Klára Éles, Yehuda Shoenfeld, Miklós Kásler, Susan Costantini, Francesca Capone, Farnaz Moradi, Pontus Berglund, Karin Leandersson, Rickard Linnskog, Tommy Andersson, Chandra Prakash Prasad, Cristiana Lo Nigro, Laura Lattanzio, Hexiao Wang, Charlotte M. Proby, Nelofer Syed, Marcella Occelli, Carolina Cauchi, Marco Merlano, Catherine Α. Harwood, Alastair M. Thompson, Tim Crook, Katia Bifulco, Vincenzo Ingangi, Michele Minopoli, Concetta Ragone, Antonello Pessi, Francesco Mannavola, Stella D’Oronzo, Claudia Felici, Marco Tucci, Antonio Doronzo, Franco Silvestris, Anna Ferretta, Stefania Guida,
... reduction in Tregs and MDSCs Yago Pico de Coaña, Maria Wolodarski, Yuya Yoshimoto, Giusy Gentilcore, Isabel Poschke, ...
BioMed Central
Michele Cassano, Eugenio De Corso, Valeria Fiore, Rossana Giancaspro, Antonio Moffa, Manuele Casale, Eleonora M. C. Trecca, Dario Antonio Mele, Pasquale Cassano, Matteo Gelardi,
... era confinato alla metà superiore del rinofaringe, con coana sufficientemente pervia e visualizzazione dell’ostio tubarico: Grado ... il tessuto adenoideo raggiungeva il bordo inferiore della coana senza consentire la visualizzazione dell’ostio tubarico: Grado ...
Tópico(s): Obstructive Sleep Apnea Research
2022 - Pacini Editore Medicina | Acta Otorhinolaryngologica Italica
Produção Nacional
Lucianne Leigue dos Santos, Fabiano Montiani Ferreira, Samuel Lopes, Larissa Anuska Zeni Condas, Marisol Dominguez Muro, Camile Lugarini,
... neoformans e outras leveduras patogenicas na cloaca e coana de passeriformes e psitaciformes e em excretas coletadas ... amostras positivas para C. albicans (duas amostras de coana), C. famata (uma amostra de coana) e C. tropicalis (uma amostra de coana). As excretas foram negativas para C. neoformans. Portanto, ...
Tópico(s): Nail Diseases and Treatments
2009 - | Arquivos de Ciências Veterinárias e Zoologia da UNIPAR
Stephan A. Schug, D. Zech, Stefan Grond, Helena Jung, Thomas Meuser, B. Stobbe,
... to the concomitant administration of nonopioids and specijic coana&ics in most patients, rexdted in a low ...
Tópico(s): Pharmacological Effects and Toxicity Studies
1992 - Elsevier BV | Journal of Pain and Symptom Management
Yago Pico de Coaña, Josefa Rodrı x guez, Eduar Guerrero, Carlos A. Barrero, Raúl Rodrı x guez, Marcela Mendoza, Manuel A. Patarroyo,
The New World primate Aotus nancymaae is susceptible to infection by the human malaria parasite Plasmodium vivax and has therefore been recommended by the World Health Organization as a model for malaria vaccine candidate evaluation. We report the isolation, adaptation, titration and genetic characterization of a P. vivax wild strain in splenectomized A. nancymaae monkeys. Parasitemia remained high after 22 passages, reaching 7.88% by Giemsa and Acridine Orange staining and Real-Time PCR determination, ...
Tópico(s): Aquaculture disease management and microbiota
2003 - Elsevier BV | Vaccine
Yago Pico de Coaña, Nuria Parody, Miguel A. Fuertes, Jerónimo Carnés, D. Roncarolo, Renato Ariano, J. Sastre, Gianni Mistrello, Conchita Alonso,
Sensitization to Cupressaceae pollen has become one of the most important causes of pollinosis in Western countries during winter and early spring. However, the characterization of the extracts, the allergens involved and the cross-reactivity with other pollen sources still remain poorly studied; in the case of Cupressus arizonica only two allergens have been described so far. A new allergen from C. arizonica pollen, Cup a 4, was cloned and expressed in Escherichia coli as an N-terminally His-tag ...
Tópico(s): Mycotoxins in Agriculture and Food
2010 - Elsevier BV | Biochemical and Biophysical Research Communications
Gilberto da Fontoura Rey Bergonse, Arakem Fernando Carneiro, Tríssia Maria Farah Vassoler,
Atresia de coanas é uma patologia rara cuja incidência varia de 1:5.000-8.000 nascidos vivos, sendo mais comum no sexo feminino e associada a outras malformações. FORMA DE ESTUDO: clínico retrospectivo. Quando unilateral, tem seu diagnóstico retardado pela carência de sintomas, porém, quando bilateral, necessita de tratamento imediato devido à insuficiência respiratória e à incapacidade de o recém nascido realizar respiração oral. Neste artigo relatamos a incidência e a experiência do HRAC-USP.
Tópico(s): Cleft Lip and Palate Research
2005 - Sociedade Brasileira de Otorrinolaringologia | Revista Brasileira de Otorrinolaringologia
Produção Nacional
Edmir Américo Lourenço, Karen de Carvalho Lopes, Álvaro Pontes, Marcelo Henrique de Oliveira, Adriana Umemura, Ana Laura Vargas,
... cavidade nasofaríngea, próxima à tuba auditiva e à coana. Ela desempenha um papel relevante nas otites médias ...
Tópico(s): Ear Surgery and Otitis Media
2005 - Sociedade Brasileira de Otorrinolaringologia | Revista Brasileira de Otorrinolaringologia
Yago Pico de Coaña, Giuseppe Masucci, Johan Hansson, Rolf Kiessling,
Immune checkpoints are a series of inhibitory pathways that are crucial for modulating the intensity and duration of immune response. Among these checkpoints, cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) has been shown to be a key regulator of the early activation of naïve and memory T cells. Immune checkpoint blockade is emerging as one of the most promising therapeutic approaches directed toward the activation of the immune response against tumors. The first of these therapies that has ...
Tópico(s): Immunotherapy and Immune Responses
2014 - Springer Science+Business Media | Cancer Immunology Immunotherapy
Yumeng Mao, Isabel Poschke, Erik Wennerberg, Yago Pico de Coaña, Suzanne Egyházi Brage, Inkeri Schultz, Johan Hansson, Giuseppe Masucci, Andreas Lundqvist, Rolf Kiessling,
Tumors can suppress the host immune system by employing a variety of cellular immune modulators, such as regulatory T cells, tumor-associated macrophages, and myeloid-derived suppressor cells (MDSC). In the peripheral blood of patients with advanced stage melanoma, there is an accumulation of CD14(+)HLA-DR(lo/-) MDSC that suppress autologous T cells ex vivo in a STAT-3-dependent manner. However, a precise mechanistic basis underlying this effect is unclear, particularly with regard to whether the ...
Tópico(s): Immunotherapy and Immune Responses
2013 - American Association for Cancer Research | Cancer Research
Yago Pico de Coaña, Isabel Poschke, Giusy Gentilcore, Yumeng Mao, Maria Nyström, Johan Hansson, Giuseppe Masucci, Rolf Kiessling,
Abstract Blocking the immune checkpoint molecule CTL antigen-4 (CTLA-4) with ipilimumab has proven to induce long-lasting clinical responses in patients with metastatic melanoma. To study the early response that takes place after CTLA-4 blockade, peripheral blood immune monitoring was conducted in five patients undergoing ipilimumab treatment at baseline, three and nine weeks after administration of the first dose. Along with T-cell population analysis, this work was primarily focused on an in-depth ...
Tópico(s): Immune Cell Function and Interaction
2013 - American Association for Cancer Research | Cancer Immunology Research
Subray S. Hegde, Farah Javid-Majd, John S. Blanchard,
... Isovaleryl-CoA275 ± 243.8 ± 0.020.13 Gluteryl-CoANA Acetoacetyl-CoANAB Sisomicin1-dSubstrate exhibiting substrate activation.3. ...
Tópico(s): Antibiotic Resistance in Bacteria
2001 - Elsevier BV | Journal of Biological Chemistry
Yago Pico de Coaña, Aniruddha Choudhury, Rolf Kiessling,
•Immune checkpoints dampen T cell activation, avoiding excessive immune responses. •CTLA-4 and PD-1 are currently the two most clinically relevant immune checkpoints. •Checkpoint blockade acts by activating the immune system to eliminate tumors. •Checkpoint-blockade therapies have shown impressive increases in overall survival. Immune checkpoint receptors are crucial molecules for fine-tuning immune responses. Checkpoint signaling dampens T cell activation to avoid autoimmunity and the destructive ...
Tópico(s): Immunotherapy and Immune Responses
2015 - Elsevier BV | Trends in Molecular Medicine
Rossana Tallerico, Costanza Maria Cristiani, Elina Staaf, Cinzia Garofalo, Rosa Sottile, Mariaelena Capone, Yago Pico de Coaña, Gabriele Madonna, Eleonora Palella, Maria Wolodarski, Valentina Carannante, Domenico Mallardo, Ester Simeone, Antonio M. Grimaldi, Sven‐Erik Johansson, Paolo Frumento, Elio Gulletta, Andrea Anichini, Francesco Colucci, Gennaro Ciliberto, Rolf Kiessling, Klas Kärre, Paolo A. Ascierto, Ennio Carbone,
Despite the success of immune checkpoint blockade in melanoma, the majority of patients do not respond. We hypothesized that the T and NK cell subset frequencies and expression levels of their receptors may predict responses and clinical outcome of anti-CTLA-4 treatment. We thus characterized the NK and T cell phenotype, as well as serum levels of several cytokines in 67 melanoma patients recruited in Italy and Sweden, using samples drawn prior to and during treatment. Survival correlated with low ...
Tópico(s): Immunotherapy and Immune Responses
2016 - Landes Bioscience | OncoImmunology
Viktor Umansky, Gosse J. Adema, Jarosław Baran, Sven Brandau, Jo A. Van Ginderachter, Xiaoying Hu, Jadwiga Jabłońska, Slavko Mojsilović, Helen Α. Papadaki, Yago Pico de Coaña, Kim Santegoets, Juan F. Santibáñez, Karine Serre, Yu Si, Izabela Siemińska, Maria Velegraki, Zvi G. Fridlender,
Tópico(s): Immune Cell Function and Interaction
2018 - Springer Science+Business Media | Cancer Immunology Immunotherapy
Maarten A. Ligtenberg, Yago Pico de Coaña, Taisia Shmushkovich, Yuya Yoshimoto, Iva Truxová, Yuan Yang, Monica Betancur-Boissel, А. В. Елисеев, Alexey Wolfson, Rolf Kiessling,
Adoptive cell therapy (ACT) is becoming a prominent alternative therapeutic treatment for cancer patients relapsing on traditional therapies. In parallel, antibodies targeting immune checkpoint molecules, such as cytotoxic-T-lymphocyte-associated antigen 4 (CTLA-4) and cell death protein 1 pathway (PD-1), are rapidly being approved for multiple cancer types, including as first line therapy for PD-L1-expressing non-small-cell lung cancer. The combination of ACT and checkpoint blockade could substantially ...
Tópico(s): RNA Interference and Gene Delivery
2018 - Elsevier BV | Molecular Therapy
Maritza Bermúdez, Gabriela Arévalo‐Pinzón, Laura Peralta Rubio, Olivier Chaloin, Sylviane Muller, Hernando Curtidor, Manuel A. Patarroyo,
... strains adapted in non-human primates (Pico de Coana et al., 2003) or infected patients' blood (Bozdech ...
Tópico(s): Vector-borne infectious diseases
2018 - Wiley | Cellular Microbiology
Yago Pico de Coaña, Maria Wolodarski, Irene van der Haar Àvila, Takahiro Nakajima, Stamatina Rentouli, Andreas Lundqvist, Giuseppe Masucci, Johan Hansson, Rolf Kiessling,
Blockade of the PD-1 receptor has revolutionized the treatment of metastatic melanoma, with significant increases in overall survival (OS) and a dramatic improvement in patient quality of life. Despite the success of this approach, the number of benefitting patients is limited and there is a need for predictive biomarkers as well as a deeper mechanistic analysis of the cellular populations involved in clinical responses. With the aim to find predictive biomarkers for PD-1 checkpoint blockade, an ...
Tópico(s): Immune Cell Function and Interaction
2020 - Landes Bioscience | OncoImmunology
Mansour Poorebrahim, Jeroen Melief, Yago Pico de Coaña, Stina L. Wickström, Ángel Cid-Arregui, Rolf Kiessling,
In spite of high rates of complete remission following chimeric antigen receptor (CAR) T cell therapy, the efficacy of this approach is limited by generation of dysfunctional CAR T cells in vivo, conceivably induced by immunosuppressive tumor microenvironment (TME) and excessive antigen exposure. Exhaustion and senescence are two critical dysfunctional states that impose a pivotal hurdle for successful CAR T cell therapies. Recently, modified CAR T cells with an "exhaustion-resistant" phenotype have ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2020 - Springer Nature | Oncogene
Haris Babačić, Janne Lehtiö, Yago Pico de Coaña, Maria Pernemalm, Hanna Eriksson,
Immune checkpoint inhibitors (ICIs) have significantly improved the outcome in metastatic cutaneous melanoma (CM). However, therapy response is limited to subgroups of patients and clinically useful predictive biomarkers are lacking.To discover treatment-related systemic changes in plasma and potential biomarkers associated with treatment outcome, we analyzed serial plasma samples from 24 patients with metastatic CM, collected before and during ICI treatment, with mass-spectrometry-based global proteomics ( ...
Tópico(s): Immunotherapy and Immune Responses
2020 - BMJ | Journal for ImmunoTherapy of Cancer
Soudabeh Rad Pour, Yago Pico de Coaña, Xavier Martinez Demorentin, Jeroen Melief, Manjula Thimma, Maria Wolodarski, David Gómez-Cabrero, Johan Hansson, Rolf Kiessling, Jesper Tegnér,
While programmed cell death receptor 1 (PD-1) blockade treatment has revolutionized treatment of patients with melanoma, clinical outcomes are highly variable, and only a fraction of patients show durable responses. Therefore, there is a clear need for predictive biomarkers to select patients who will benefit from the treatment.To identify potential predictive markers for response to PD-1 checkpoint blockade immunotherapy, we conducted single-cell RNA sequencing analyses of peripheral blood mononuclear ...
Tópico(s): Single-cell and spatial transcriptomics
2021 - BMJ | Journal for ImmunoTherapy of Cancer
David Virós Porcuna, J.R. Montserrat Gili, Juan R. Gras-Cabrerizo, Montse López Vilas, Albert Pujol Olmo,
... hacia la fosa nasal en dirección a la coana. Es una enfermedad unilateral que afecta principalmente a ...
Tópico(s): Oral and Maxillofacial Pathology
2008 - Elsevier BV | Acta Otorrinolaringológica Española
Produção Nacional
Revisado por pares
Ilka Yamashiro, Ricardo Pires de Souza,
... Anteriormente, comunica-se com a cavidade nasal via coana posterior. Mede cerca de 2,0 cm de ...
Tópico(s): Head and Neck Cancer Studies
2007 - Colégio Brasileiro de Radiologia e Diagnóstico por Imagem | Radiologia Brasileira
Produção Nacional
Marcos Rabelo de Freitas, Rogério Pinto Giesta, Sebastião Diógenes Pinheiro, Viviane Carvalho da Silva,
... para a cavidade nasal e em direção a coana e parte posterior da nasofaringe, podendo estender-se ...
Tópico(s): Nasal Surgery and Airway Studies
2006 - Sociedade Brasileira de Otorrinolaringologia | Revista Brasileira de Otorrinolaringologia
Rodrigo Gaete, Àngel Galobart Lorente, Xavier Ros,
... craneo y de las orbitas, forma de la coana del paladar...) y de la mandibula nos acercan ...
Tópico(s): Ichthyology and Marine Biology
1993 - | Treballs del Museu de Geologia de Barcelona
Aotus spp. monkeys are considered the ideal model for studying the progress of malarial infection and the immune response it elicits. We describe the use of a recently developed technique, real-time quantitative RT-PCR, to quantify several Aotus monkey cytokine mRNAs involved in Th1/Th2 responses (IL-4, IL-10, TNF-beta and IFN-gamma). Specific primers were designed for each cytokine and standard curves were constructed using serial dilutions of pDNA containing each target sequence. Results were normalized ...
Tópico(s): Herpesvirus Infections and Treatments
2004 - Elsevier BV | Cytokine
Hugo Bernardo, Luis Guillermo Meléndez Hernández, Juan Carlos Ayala Calvo, José Luís Llorente, José Luis Gómez,
... nasal (95%), en ocasiones con extensión a la coana (38%) y al cavum (23%). La se-gunda ...
Tópico(s): Bone Tumor Diagnosis and Treatments
2001 - Elsevier BV | Radiología
Yago Pico de Coaña, Nuria Parody, Enrique Fernández‐Caldas, Carlos Alonso‐Moreno,
Tópico(s): Research in Cotton Cultivation
2009 - Springer Science+Business Media | Molecular Biotechnology