... portrait paintings by Danish artists Jens Juel and Constantin Hansen and argues that the discrepancy between the pupils ...
Tópico(s): Visual Culture and Art Theory
2019 - Taylor & Francis | Journal of Aesthetics and Phenomenology
Constantin Hansens enorme maleri af den grundlovgivende rigsforsamling er blevet en ikonisk illustration på den danske overgang fra ... bestillingsmotivets endelige komposition er kun blevet overfladisk behandlet. Constantin Hansen var dog en meget engageret samfundsborger, der var levende optaget af politik og som deltog aktivt ...
Tópico(s): Historical Influence and Diplomacy
2020 - Dansk Historisk Fællesråd & Foreningen Danmarks Folkeminder | Kulturstudier
Johan Rung, Stéphane Cauchi, Anders Albrechtsen, Li Shen, Ghislain Rocheleau, Christine Cavalcanti-Proença, François Bacot, Beverley Balkau, Alexandre Bélisle, Knut Borch‐Johnsen, G. Charpentier, Christian Dina, Emmanuelle Durand, Paul Elliott, Samy Hadjadj, Marjo‐Riitta Järvelin, Jaana Laitinen, Torsten Lauritzen, Michel Marre, Alexander M. Mazur, Stephen Eyre, Alexandre Montpetit, Charlotta Pisinger, Barry I. Posner, Pernille Poulsen, Anneli Pouta, Marc Prentki, Rasmus Ribel‐Madsen, Aimo Ruokonen, Anelli Sandbæk, David Serre, Jean Tichet, Martine Vaxillaire, Jørgen F. P. Wojtaszewski, Allan Vaag, Torben Hansen, Constantin Polychronakos, Oluf Pedersen, Philippe Froguel, Robert Sladek,
Tópico(s): Pancreatic function and diabetes
2009 - Nature Portfolio | Nature Genetics
Jasper A. Wassenburg, Sylvia Riechelmann, Andrea Schröder‐Ritzrau, Dana F.C. Riechelmann, Daniel Richter, Adrian Immenhauser, Mihai Terente, Silviu Constantin, Andrea Hachenberg, Maximilian Hansen, Denis Scholz,
Trace element to Ca ratios in speleothems have emerged as important proxies that reflect local environmental conditions. However, interpretations of speleothem trace element records can be challenging due to various processes. Positive correlations between speleothem Mg/Ca and Sr/Ca have often been interpreted to reflect prior calcite precipitation (PCP), a process potentially modulated by rainfall variability. For quantitative interpretation of PCP, the distribution coefficients for Mg and Sr (DMg ...
Tópico(s): Groundwater and Isotope Geochemistry
2019 - Elsevier BV | Geochimica et Cosmochimica Acta
Martin Dominik Leclaire, Gerburg Nettels-Hackert, Jeannette König, Annika Höhn, Tilman Grune, Constantin E. Uhlig, Uwe Hansen, Nicole Eter, Peter Heiduschka,
Tópico(s): Neurological Disease Mechanisms and Treatments
2019 - Springer Science+Business Media | Graefe s Archive for Clinical and Experimental Ophthalmology
Sedat Gündoğdu, Agathe Bour, Ali Rıza Köşker, Bruno Walther, Dorota Napierska, Florin�-�Constantin Mihai, Kristian Syberg, Steffen Foss Hansen, Tony R. Walker,
Plastic overproduction and the resulting increase in consumption has made plastic pollution ubiquitous in all ecosystems. Recognizing this, the United Nations (UN) has started negotiations to establish a global treaty to end plastic pollution, especially in the marine environment. The basis of the treaty has been formulated in terms of turning off the tap, signaling the will to prevent plastic pollution at its source. Based on the distribution of plastic production by sector, the plastic packaging ...
Tópico(s): biodegradable polymer synthesis and properties
2024 - Elsevier BV | The Science of The Total Environment
Produção Nacional
Revisado por pares
Xiaoming Jie, Constantin G. Daniliuc, Robert Knitsch, Michael Ryan Hansen, Hellmut Eckert, Sebastian Ehlert, Stefan Grimme, Gerald Kehr, Gerhard Erker,
Abstract A new six‐membered cyclic frustrated phosphane/borane Lewis pair was liberated from its HB(C 6 F 5 ) 2 adduct by treatment with vinylcyclohexane. The system is an active frustrated Lewis pair that undergoes cycloaddition reactions with suitable π reagents and it splits dihydrogen. At room temperature in solution the new compound is a monomer, however, in the crystal and in solution at low temperature it aggregates to a thermodynamically favoured supramolecular macrocyclic cyclooctamer.
Tópico(s): Boron Compounds in Chemistry
2018 - Wiley | Angewandte Chemie International Edition
Produção Nacional
Revisado por pares
Xiaoming Jie, Qiu Sun, Constantin G. Daniliuc, Robert Knitsch, Michael Ryan Hansen, Hellmut Eckert, Gerald Kehr, Gerhard Erker,
The active six-membered cyclo-FLP 6 undergoes a rapid P/B addition reaction to carbon dioxide. At elevated temperature, the resulting heterobicyclo[2.2.2]octane derived product 7 undergoes ring opening and equilibrates with the cyclotetramer (7)4 . In the large macrocyclic structure, four monomeric six-membered cyclo-FLP units are connected by four CO2 molecules to form the supramolecular ring system. The P/B cyclo-FLP 6 undergoes a variety of additional cycloaddition reactions.
Tópico(s): Synthesis and characterization of novel inorganic/organometallic compounds
2019 - Wiley | Chemistry - A European Journal
Produção Nacional
Revisado por pares
Xin Tao, Constantin G. Daniliuc, Robert Knitsch, Michael Ryan Hansen, Hellmut Eckert, Maximilian Lübbesmeyer, Armido Studer, Gerald Kehr, Gerhard Erker,
In the presence of two molar equiv. of B(C6F5)3p-benzoquinone reacts with persistent radicals TEMPO, trityl or decamethylferrocene by single electron transfer to give doubly O-borylated benzosemiquinone radical anions with TEMPO+, trityl or ferrocenium counter cations. All three [(C6F5)3B]2-semiquinone radical anion salts were characterized by X-ray diffraction. The addition of donor reagent THF or DMSO induced rapid back electron transfer, in the case of the [(C6F5)3B]2-semiquinone radical anion oxoammonium ...
Tópico(s): Radical Photochemical Reactions
2018 - Royal Society of Chemistry | Chemical Science
Felix Scheidt, Philipp Selter, Nico Santschi, Mareike C. Holland, Dmytro Dudenko, Constantin G. Daniliuc, Christian Mück‐Lichtenfeld, Michael Ryan Hansen, Ryan Gilmour,
Abstract Pervasive in Nature, the propane unit is an essential component of numerous bioactive molecules. These range from acyclic systems, such as the neurotransmitter γ‐aminobutyric acid, through to the bicyclic nuclei of various chromanes and dihydrobenzofurans. In the latter case, cyclisation via cyclic ether formation ensures a highly pre‐organised structure, whilst linear scaffolds display more dynamic conformational behaviour resulting from rotation about the two internal C(sp 3 )–C(sp 3 ) bonds. ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2016 - Wiley | Chemistry - A European Journal
John J. Mitchell, Zubin Punthakee, Bernard Lo, C. Bernard, Karen Chong, Catherine E. Newman, Lola Cartier, Valérie Désilets, E. Cutz, Inger Lise Skog Hansen, P Riley, Constantin Polychronakos,
Neonatal diabetes is a rare disease with several identified molecular aetiologies. Despite associations with other malformations, neonatal diabetes with intestinal and biliary anomalies has not been described. The current study aims to describe a new syndrome, and to examine a possible link with one of three genes known to cause neonatal diabetes.Five clinical cases are described. Immunohistochemical staining for pancreatic islet hormones was performed on three of the infants. DNA from one infant ...
Tópico(s): Diabetes and associated disorders
2004 - Springer Science+Business Media | Diabetologia
Klaus Scheller, Constantin E. Sekeris, Georg Krohne, Robert Hock, Immo A. Hansen, Ulrich Scheer,
Tópico(s): Adipose Tissue and Metabolism
2000 - Elsevier BV | European Journal of Cell Biology
Produção Nacional
Revisado por pares
Xiaoming Jie, Constantin G. Daniliuc, Robert Knitsch, Michael Ryan Hansen, Hellmut Eckert, Sebastian Ehlert, Stefan Grimme, Gerald Kehr, Gerhard Erker,
Abstract A new six‐membered cyclic frustrated phosphane/borane Lewis pair was liberated from its HB(C 6 F 5 ) 2 adduct by treatment with vinylcyclohexane. The system is an active frustrated Lewis pair that undergoes cycloaddition reactions with suitable π reagents and it splits dihydrogen. At room temperature in solution the new compound is a monomer, however, in the crystal and in solution at low temperature it aggregates to a thermodynamically favoured supramolecular macrocyclic cyclooctamer.
Tópico(s): Boron Compounds in Chemistry
2018 - Wiley | Angewandte Chemie
J. T. Mitchell, Y. Akiba, L. Aphecetche, R. Averbeck, T. C. Awes, V. Baublis, A. Bazilevsky, Malcolm J. Bennett, H. Buesching, J. M. Burward-Hoy, S. Butsyk, M. Chiu, T. Christ, T. Chujo, P. Constantin, G. David, A. Denisov, A. Drees, A. G. Hansen, T. K. Hemmick, J. Jia, S. C. Johnson, E. Kistenev, A. Kiyomichi, T. Kohama, J. G. Lajoie, J. Lauret, A. Lebedev, C. Maguire, F. Messer, P. Nilsson, H. Ohnìshì, J Park, M. Rosati, A. Rose, S. S. Ryu, A. Sakaguchi, S. Sato, K. Shigaki, D. Silvermyr, T. Sugitate, J. P. Sullivan, M. Suzuki, H. Tydesjö, H.W Van Hecke, J. Velkovska, М. А. Volkov, S. N. White, W. Xie,
The central arm spectrometers for the PHENIX experiment at the Relativistic Heavy Ion Collider have been designed for the optimization of particle identification in relativistic heavy ion collisions. The spectrometers present a challenging environment for event reconstruction due to a very high track multiplicity in a complicated, focusing, magnetic field. In order to meet this challenge, nine distinct detector types are integrated for charged particle tracking, momentum reconstruction, and particle ...
Tópico(s): Particle Detector Development and Performance
2002 - Elsevier BV | Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment
Kim,
... Christ-offer Wilhelm Eckersberg, Peder Severin Krłyer, and Constantin Hansen are some of the better known artists that ...
Tópico(s): Travel Writing and Literature
2012 - Indiana University Press | Victorian Studies
... to the group of Danish painters (Vilhelm Marstrand, Constantin Hansen, J⊘rgen Sonne, J⊘rgen Roed etc.) who ...
Tópico(s): Conservation Techniques and Studies
1993 - Taylor & Francis | Konsthistorisk tidskrift/Journal of Art History
Produção Nacional
Revisado por pares
Xin Tao, Constantin G. Daniliuc, Oliver Janka, Rainer Pöttgen, Robert Knitsch, Michael Ryan Hansen, Hellmut Eckert, Maximilian Lübbesmeyer, Armido Studer, Gerald Kehr, Gerhard Erker,
Abstract Triplet dioxygen was reduced by TEMPO or trityl radicals in the presence of two molar equivalents of the strong B( p ‐C 6 F 4 X) 3 (X: F or H) boron Lewis acids under mild conditions to give the bis(borane)superoxide systems 2 . The sensitive radical anion species were isolated and characterized by methods including X‐ray crystal structure analysis and EPR spectroscopy.
Tópico(s): Radical Photochemical Reactions
2017 - Wiley | Angewandte Chemie International Edition
Shifaa M. Abdin, Daniela Paasch, Arnold Kloos, Marco Carvalho Oliveira, Mi-Sun Jang, Mania Ackermann, Ανδριάνα Σταμοπούλου, Philipp J Mroch, Christine S. Falk, Constantin S. von Kaisenberg, Axel Schambach, Michael Heuser, Thomas Moritz, Gesine Hansen, Michael Morgan, Nico Lachmann,
Background Macrophages have recently become attractive therapeutics in cancer immunotherapy. The potential of macrophages to infiltrate and influence solid malignancies makes them promising targets for the chimeric antigen receptor (CAR) technology to redirect their stage of polarization, thus enhancing their anticancer capacities. Given the emerging interest for CAR-macrophages, generation of such cells so far mainly depends on peripheral blood monocytes, which are isolated from the respective donor ...
Tópico(s): Renal and related cancers
2023 - BMJ | Journal for ImmunoTherapy of Cancer
Produção Nacional
Revisado por pares
Long Wang, Shunxi Dong, Constantin G. Daniliuc, Lei Liu, Stefan Grimme, Robert Knitsch, Hellmut Eckert, Michael Ryan Hansen, Gerald Kehr, Gerhard Erker,
The trifunctional P/B/B frustrated Lewis pairs
Tópico(s): Coordination Chemistry and Organometallics
2017 - Royal Society of Chemistry | Chemical Science
Lorena Herkert, Philipp Selter, Constantin G. Daniliuc, Nils Bäumer, Jasnamol P. Palakkal, Gustavo Fernández, Michael Ryan Hansen,
Abstract Understanding the relationship between molecular design and packing modes constitutes one of the major challenges in self‐assembly and is essential for the preparation of functional materials. Herein, we have achieved high precision control over the supramolecular packing of amphiphilic Pt II complexes by systematic variation of the hydrophilic side‐chain length. A novel approach of general applicability based on complementary X‐ray diffraction and solid‐state NMR spectroscopy has allowed ...
Tópico(s): Metal-Organic Frameworks: Synthesis and Applications
2020 - Wiley | Chemistry - A European Journal
Søren Thor Larsen, Constantin Dallot, Susan Weng Larsen, Fabrice Rose, Steen Seier Poulsen, Asger W. Nørgaard, Jitka Stilund Hansen, Jorid B. Sørli, Gunnar Damgård Nielsen, Camilla Foged,
Inhalation of waterproofing spray products has on several occasions caused lung damage, which in some cases was fatal. The present study aims to elucidate the mechanism of action of a nanofilm spray product, which has been shown to possess unusual toxic effects, including an extremely steep concentration-effect curve. The nanofilm product is intended for application on non-absorbing flooring materials and contains perfluorosiloxane as the active film-forming component. The toxicological effects ...
Tópico(s): Cardiovascular and Diving-Related Complications
2014 - Oxford University Press | Toxicological Sciences
Chaohuang Chen, Constantin G. Daniliuc, Sina Klabunde, Michael Ryan Hansen, Gerald Kehr, Gerhard Erker,
Examples of isolated boron substituted nitroxide radicals are rare. The reaction of the reactive cyclic boraalkene 3 with nitrosobenzene yields a mixture of the [2 + 2] cycloaddition product 4a, the B-nitroxide radicals 5a and 6a and the azoxybenzene co-product 7avia a bora nitroso ene reaction pathway, the boron analogue of the nitroso ene reaction. The products were separated by flash chromatography, and the B-nitroxide radicals were characterized by X-ray diffraction and EPR spectroscopy. Radical ...
Tópico(s): Catalytic C–H Functionalization Methods
2022 - Royal Society of Chemistry | Chemical Science
Jan Gerit Brandenburg, Georg Bender, Jinjun Ren, Andreas Hansen, Stefan Grimme, Hellmut Eckert, Constantin G. Daniliuc, Gerald Kehr, Gerhard Erker,
We present a combined theoretical and experimental analysis of the carbon–carbon bond character in two prototypical zirconocene complexes. The two cyclic seven-membered ring zirconium compounds 2a and 2b differ by the substitution of a tert-butyl by a trimethylsilyl group. Due to the coordination of the π-system to the metal atom, a formally forbidden (η2-allenyl)/enamido-Zr to (η2-alkyne)/κN-imine-Zr complex isomerization is feasible. State-of-the-art dispersion-corrected density functional theory ( ...
Tópico(s): Organoboron and organosilicon chemistry
2014 - American Chemical Society | Organometallics
Johan Rung, Stéphane Cauchi, Anders Albrechtsen, Li Shen, Ghislain Rocheleau, Christine Cavalcanti-Proença, François Bacot, Beverley Balkau, Alexandre Bélisle, Knut Borch‐Johnsen, G. Charpentier, Christian Dina, Emmanuelle Durand, Paul Elliott, Samy Hadjadj, Marjo‐Riitta Järvelin, Jaana Laitinen, Torsten Lauritzen, Michel Marre, Alexander M. Mazur, Stephen Eyre, Alexandre Montpetit, Charlotta Pisinger, Barry I. Posner, Pernille Poulsen, Anneli Pouta, Marc Prentki, Rasmus Ribel‐Madsen, Aimo Ruokonen, Anelli Sandbæk, David Serre, Jean Tichet, Martine Vaxillaire, Jørgen F. P. Wojtaszewski, Allan Vaag, Torben Hansen, Constantin Polychronakos, Oluf Pedersen, Philippe Froguel, Robert Sladek,
Nat. Genet. 41, 1110–1115; published online 6 September; corrected online 13 September 2009 In the version of this article initially published online, there were errors in the e-mail addresses of two of the corresponding authors. The correct e-mail address for Robert Sladek is robert.sladek@mcgill.ca; the correct e-mail address for Philippe Froguel is philippe.
Tópico(s): RNA modifications and cancer
2009 - Nature Portfolio | Nature Genetics
Eva Querdel, Marina Reinsch, Liesa Castro, Deniz Köse, Andrea Bähr, Svenja Reich, Birgit Geertz, Bärbel Ulmer, Mirja L. Schulze, Marc D. Lemoine, Tobias Krause, Marta Lemme, Jascha Sani, Aya Shibamiya, Tim Stüdemann, Maria Köhne, Constantin von Bibra, Nadja Hornaschewitz, S. Pecha, Yusuf Nejahsie, Ingra Mannhardt, Torsten Christ, Hermann Reichenspurner, Arne Hansen, Nikolai Klymiuk, Markus Krane, Christian Kupatt, Thomas Eschenhagen, Florian Weinberger,
Human engineered heart tissue (EHT) transplantation represents a potential regenerative strategy for patients with heart failure and has been successful in preclinical models. Clinical application requires upscaling, adaptation to good manufacturing practices, and determination of the effective dose.Cardiomyocytes were differentiated from 3 different human induced pluripotent stem cell lines including one reprogrammed under good manufacturing practice conditions. Protocols for human induced pluripotent ...
Tópico(s): Neuroscience and Neural Engineering
2021 - Lippincott Williams & Wilkins | Circulation
Felix Becker, Linus Kebschull, Constantin Rieger, Annika Mohr, Barbara Heitplatz, Veerle Van Marck, Uwe Hansen, Junaid Ansari, Stefan Reuter, Benjamin Strücker, Andreas Pascher, Jens Brockmann, Trevor Castor, J. Steven Alexander, Felicity N. E. Gavins,
Ischemia reperfusion injury (IRI) is a form of sterile inflammation whose severity determines short- and long-term graft fates in kidney transplantation. Neutrophils are now recognized as a key cell type mediating early graft injury, which activates further innate immune responses and intensifies acquired immunity and alloimmunity. Since the macrolide Bryostatin-1 has been shown to block neutrophil transmigration, we aimed to determine whether these findings could be translated to the field of kidney ...
Tópico(s): Blood disorders and treatments
2022 - Multidisciplinary Digital Publishing Institute | Cells
Benedikt Sieland, Marcel Stahn, Roland Schoch, Constantin G. Daniliuc, Sebastian Spicher, Stefan Grimme, Andreas Hansen, Jan Paradies,
An isostructural series of boron/phosphorus Lewis pairs was systematically investigated. The association constants of the Lewis pairs were determined at variable temperatures, enabling the extraction of thermodynamic parameters. The stabilization of the Lewis adduct increased with increasing size of the dispersion energy donor groups, although the donor and acceptor properties of the Lewis pairs remained largely unchanged. This data was utilized to challenge state-of-the-art quantum chemical methods, ...
Tópico(s): Crystallography and molecular interactions
2023 - Wiley | Angewandte Chemie International Edition
Constantin von Bibra, Aya Shibamiya, Birgit Geertz, Eva Querdel, Maria Köhne, Tim Stüdemann, Jutta Starbatty, Felix N. Schmidt, Arne Hansen, Bernhard Hiebl, Thomas Eschenhagen, Florian Weinberger,
Myocardial injury leads to an irreversible loss of cardiomyocytes (CM). The implantation of human engineered heart tissue (EHT) has become a promising regenerative approach. Previous studies exhibited beneficial, dose-dependent effects of human induced pluripotent stem cell (hiPSC)-derived EHT patch transplantation in a guinea pig model in the subacute phase of myocardial injury. Yet, advanced heart failure often results from a chronic remodeling process. Therefore, from a clinical standpoint it is ...
Tópico(s): Pluripotent Stem Cells Research
2022 - Elsevier BV | Journal of Molecular and Cellular Cardiology
Torsten Hansen, C. Constantin, Matthias Weber, Ulf Titze, Fritz Hartmann,
Tópico(s): Eosinophilic Disorders and Syndromes
2019 - Springer Science+Business Media | Der Pathologe
Åsmund Kaupang, Steinar M. Paulsen, Calin Constantin Steindal, Aina Westrheim Ravna, Ingebrigt Sylte, Trine Grønhaug Halvorsen, G. Hege Thoresen, Trond Vidar Hansen,
Herein, we describe the synthesis, biological evaluation and molecular docking of the selective PPARβ/δ antagonist (4-methyl-2-(4-(trifluoromethyl)phenyl)-N-(2-(5-(trifluoromethyl)-pyridin-2-ylsulfonyl)ethyl)thiazole-5-carboxamide)), CC618. Results from in vitro luciferase reporter gene assays against the three known human PPAR subtypes revealed that CC618 selectively antagonizes agonist-induced PPARβ/δ activity with an IC50 = 10.0 μM. As observed by LC-MS/MS analysis of tryptic digests, the treatment ...
Tópico(s): Receptor Mechanisms and Signaling
2015 - Elsevier BV | European Journal of Medicinal Chemistry