... s Overdracht-Papier, Guy De Coral & Co's Coraline!. Table of contents: Inhoud: Agenda. Essay: Fotografische Nieuwigheden, ...
1896 - Gale Group | NCCO Photography
Eva Michaud, Louis Waeckel, Rémi Gayet, Roman Goguyer‐Deschaumes, Blandine Chanut, Fabienne Jospin, Katell Bathany, Magali Monnoye, Coraline Genet, Amélie Prier, Caroline Tokarski, Philippe Gérard, Xavier Roblin, Nicolas Rochereau, Stéphane Paul,
... draft Search for more papers by this author Coraline Genet Coraline Genet Inserm UMR 1098 Right, Université Bourgogne Franche- ... draft Search for more papers by this author Coraline Genet Coraline Genet Inserm UMR 1098 Right, Université Bourgogne Franche- ... Blandine Chanut1, Fabienne Jospin1, Katell Bathany3, Magali Monnoye4, Coraline Genet5, Amelie Prier1, Caroline Tokarski3, Philippe Gérard4, Xavier ...
Tópico(s): Gut microbiota and health
2022 - Springer Nature | EMBO Molecular Medicine
... s Plates, B. Groote & Co., Barnet Rocket Platen, Coraline, Hand-Camera-Objectief.
1900 - Gale Group | NCCO Photography
Coraline Chapperon, Laurent Seuront,
... in environmental thermal properties and snail thermoregulatory behaviour Coraline Chapperon, Corresponding Author Coraline Chapperon School of Biological Sciences, Flinders University, GPO ... Wimereux, FranceSearch for more papers by this author Coraline Chapperon, Corresponding Author Coraline Chapperon School of Biological Sciences, Flinders University, GPO ...
Tópico(s): Ocean Acidification Effects and Responses
2011 - Wiley | Functional Ecology
... the Pacific Islands of a Strictly Volennic or Coraline Origin, but Is Applied by Some to the ...
1906 - Gale Group | NCCO EuropeAfrica
Marie-Paule Sablin, Coraline Dubot, Jerzy Klijanienko, Sophie Vacher, Lamia Ouafi, Walid Chemlali, Martial Caly, Xavier Sastre‐Garau, Emmanuelle Lappartient, Odette Mariani, José Rodriguez, Thomas Jouffroy, Angélique Girod, Valentin Calugaru, Caroline Hoffmann, Rosette Lidereau, Frédérique Berger, Maud Kamal, Ivan Bièche, Christophe Le Tourneau,
// Marie-Paule Sablin 1, * , Coraline Dubot 1, 2, * , Jerzy Klijanienko 3 , Sophie Vacher 2 , Lamia Ouafi 3 , Walid Chemlali 2 , Martial Caly 3 , Xavier Sastre- ... authors equally contributed to this work Correspondence to: Coraline Dubot, email: coraline.dubot@curie.fr Keywords: head and neck squamous ...
Tópico(s): Head and Neck Cancer Studies
2016 - Impact Journals LLC | Oncotarget
Steven Shukor, Jonathan Northcroft, Waldemar Januszczak, John Ellian, John Dugdale, Julia Llewellyn Smith, Frank Parker, Mrs D Hewitt, Don Cairns, Robert Wheeler, Sally Brock, Helen Davies, Nicholas Rufford, Rob Hughes, Dan Pearson, John Peter, Pam Barrett, Professor Gideon Garter, Jonathan Cox, William Lewis Business Editor, Charles Irving, Jonathan Miller, Bill Fear, Robin Eggar, Andrew Longmore, Michael Rollison, Mary Taylor, Susan d'Arcy, Peter Day, Sylvia Roger, Gareth Walsh, Frank Whitford, Ivo Tennant, John Bartlett, Nicolette Jones, Alex Todorovic, Ferdinand Mount, Sam Gilpin, Michael Leschziner Professor of Computational Aerodynamics, Kathryn Cooper, Lucy Hughes-Hallett, Jeremy Lazell's, Mitchell Prothero, Ian Cooper, Tim Richards, Humphrey Carpenter, Steven Poole, David Cracknell Political Editor, David O'Leary, Simon Harris, Richard Green, Neil Wormald, Andrew Sullivan, Clive Davis, Kate Row, Matt Goss, Bill Bond, Jacqueline Wilson, Andrew Porter, Kathy Brewis, A C, Tony Allen-Mills, Simon Wilde, Martin James, Jonathan Ungoed-Thomas, Robert Sandall, Tom Walker, G Johnson, Anthony Sattin, Robert Winnett, Steven Buckley, Dipesh Gadher Transport Correspondent, Irwin Stelzer, Stephen Pinnell, John Percy, Trevor Bateman, Peter Wilson, Gil Hancox, Rosie Millard, Chris Sullivan, Lawrence Dallaglio, David Dougill, Rachel Dobson, John Mortimer, Frank Graham, Jenni Muir, P Jones, Shena Mackay, David Hewson, Diane Abbott, Neil Stuart, David Bond, Egon Ronay, Hugh Canning, Alasdair Reid, Elizabeth Scott-Baumann, Lucy Rouse, Jeremy Clarkson, Richard Wilson, Andrew Stone, Philip Smith, Edward Porter, Jennifer Miller, Victoria Segal, David Cairns, Stewart Lee, Patricia Nicol, Edwrd Porter, Richard Tanner, Sarah Dempster, Andrew Holgate, Eben Black, Anita Chaudhuri, John O'Donnell, Rachel Morgan, Greg Struthers, Lydia Slater, Patrick Maxwell, Andy Miller, Shelley von Strunckel, Emir Feisal, Lord Monkswell, Jeremy Guscott, Paula Robinson, Rebecca Holiday, Mike Laws, Christopher Silvester, Stuart Wavell, Roger Eglin, Paul Donovan, Nigel Bowker, Chris Woodhead, Steve Boyd, Lucinda Kemeny, Paul Ormerod, Jasper Gerard, Derek Clements, Stephanie Biber, Paul Driver, John Humphrys, John Ralfe, Robert Cooper, Barry Francis, Julie Deegan, Ian Hawkey, Stuart Andrews, Alex Clark, Christopher Morgan, David Leppard, Paul Durman, Lisa Grainger, Alicia Wyllie, Mark Edwards, Peter Hutchison, Angus Steer, Susan Clark, Bob Leitch, Phil Baker, Carl Gierstorfer, Stuart Miles, James Brown, Martin Stitson, Henry Partridge, Sean Newsom, Mavis Secrett, Jim Wilson, Raymond Keene, Howard Neal, Gareth Huw Davies, Douglas Alexander, Rhona Jakins, David Cracknell, Cosmo Landesman, Sean O'Flynn, Katrina Manson, Robbie Hudson, Diana Wright, Christopher Smallwood, Stephen Jones, Dominic O'Connell, Linda McDougall, Louise Armitstead, Tom McNab British Olympic Coach, Uzi Mahnaimi, Nick Cain, Barry Flatman, Noel Aspill, Peter Koenig, Natalie Graham, Daisy Clark, Caroline Donald, Nick Rennison, Keith Wheatley, Mike Nicholls, Miranda Seymour, David Walsh, Richard Jones, John Arlide, Trevor Lewis, Colin McDowell, Bryan Appleyard, Sarah Keenlyside, Stephen Armstrong, John Elliott, Bethan Cole, Michael Sheridan Far East Correspondent, Victoria O'brien, Roland White, Norman Stone, Shane Watson, Rachel Johnson, Maurice Chittenden, Stuart Ross, Richard Brooks Arts Editor, Judith O'Reilly, Mark Franchetti, Carl Gierstofer, Richard Rae, Jon Ungoed-Thomas, Ray Hutton, Kevan Debonnaire, Simon Bell, Sophie Kirkham, John Crossland, Nicola Baker, Allan McNish, Michael Sheridan, Clare Francis, Amanda Craig, John Harlow, Philip Beresford, Godfrey Smith, John Shaw, Robert Winnett Consumer Affairs Correspondent, Mike McLeod, Neil Gaiman, Katie Pearson, Dipesh Gadher, Richard George, Rod Stewart, Barry Collins, A A Gill, David Parsons, Matthew Campbell, Brian Glanville, Enda Leahy, P Hayworth, David Hutcheon, Mary Braid, Nick Fielding, Norman Adams, Penny Lancaster, Stephen Pettitt, Maria McErlane, Howard Jacobson, Imre Karacs, Sally Kinnes, Nicholas Shakespeare, Naomi Caine, R B J T Allenby, Tom Hodgkinson's, Richard Barnard, Brian Doogan, Ben Dowell, Minette Marrin, John Aizlewood, George Davis, Mark Hodson, Jeremy Lazell, Kathleen Bennis, Andrew Frankel, Jonathan Futrell, Graham Norwood, Clifford Bishop, Barhara Hall, David Budworth, Julian Dare, William Lewis Business editor, Hugh Pearman, Paul Stephen Lubicz, Julian Ryall, Pete Oliver, Dan Cairns, Sarah Godfrey, Mrs Mills, Ashley Cole, Anthony Howard, Sarah Baxter, Helen Vandevelde, Bob Dwyer, David Robertson, Matthew Goodman, India Knight, Clive Unger-Hamilton, Simon Howard, Nina Goswami, Jason Dawe, Dominic Rushe, Ken Lunt, Richard Lewis, Karen Robinson, Walter Smith, Helen Stewart,
... more about The Powerpuff Girls Barbie Style Fresh! Coraline Viewtiful Joe Sport News Today Rugby world Cup, ...
2003 - Gale Group | Sunday Times HA GDA
Neil Gaiman’s novel Coraline (2002) has, for many critics, come to epitomize twenty-first-century gothic children’s fiction. Coraline borrows from Freud’s “The ‘Uncanny’” to create ... psychoanalytic reading of childhood. Using the case of Coraline, and remaining neutral about the truth value of ...
Tópico(s): Gothic Literature and Media Analysis
2015 - Johns Hopkins University Press | Children's Literature Association quarterly
... Goerz Dubbel-Anastigmaten, Guy De Coral & Co's Coraline!, „Foto=Nieuws".
1896 - Gale Group | NCCO Photography
Coraline D. Metzger, Coraline D. Metzger, Coraline D. Metzger, Ysbrand D. van der Werf, Ysbrand D. van der Werf, Martin eWalter, Martin eWalter, Martin eWalter,
The thalamus, a crucial node in the well-described cortico-striatal-thalamo-cortical circuits, has been the focus of functional and structural imaging studies investigating human emotion, cognition and memory. Invasive work in animals and post-mortem investigations have revealed the rich cytoarchitectonics and functional specificity of the thalamus. Given current restrictions in the spatial resolution of non-invasive imaging modalities, there is, however, a translational gap between functional and ...
Tópico(s): Neurological disorders and treatments
2013 - Frontiers Media | Frontiers in Neuroscience
While early reviews emphasized Coraline 's gothic qualities and expressed reservations about the appropriateness of the book for young readers, Neil Gaiman contended that children ... theorizing a double readership. It further contends that Coraline's varied responses to the uncanny disclose her ...
Tópico(s): Narrative Theory and Analysis
2008 - Johns Hopkins University Press | Children's Literature Association quarterly
François‐Clément Bidard, Anne‐Claire Hardy‐Bessard, Florence Dalenc, Thomas Bachelot, Jean‐Yves Pierga, Thibault De La Motte Rouge, Renaud Sabatier, Coraline Dubot, Jean‐Sébastien Frénel, Jean Marc Ferrero, Sylvain Ladoire, Christelle Lévy, Marie‐Ange Mouret‐Reynier, Alain Lortholary, Julien Grenier, Camille Chakiba, Laetitia Stefani, Jérôme Edouard Plaza, Florian Clatot, Luís Teixeira, Véronique D’Hondt, Hélène Vegas, Olfa Derbel, Claire Garnier-Tixidré, Jean-Luc Canon, Barbara Pistilli, Fabrice André, Laurent Arnould, Anne Pradines, Ivan Bièche, Céline Callens, Jérôme Lemonnier, Frédérique Berger, Suzette Delaloge, François‐Clément Bidard, Barbara Pistilli, Florence Dalenc, Thomas Bachelot, Thibault De La Motte Rouge, Renaud Sabatier, Coraline Dubot, Jean‐Sébastien Frénel, Jean-Marc Ferrero, Sylvain Ladoire, Christelle Lévy, Marie‐Ange Mouret‐Reynier, Anne‐Claire Hardy‐Bessard, Alain Lortholary, Julien Grenier, Camille Chakiba, Laetitia Stefani, P Soulié, Jean-Philippe Jacquin, Jérôme Edouard Plaza, Florian Clatot, Luís Teixeira, Véronique D’Hondt, Hélène Vegas, Olfa Derbel, Claire Garnier Tixidre, Catherine DELBALDO, Lionel MOREAU, Caroline Cheneau, Jean-François Paitel, Chantal BERNARD-MARTY, Dominique Spaeth, Dominique Genet, Isabelle MOULLET, Nathalie BONICHON-LAMICHHANE, Laura DEIANA, Charlotte GREILSAMER, Laurence Venat‐Bouvet, Valérie Delecroix, Adrien MELIS, Hubert Orfeuvre, Suzanne Nguyen, Éric Legouffe, Alain Zannetti, Romuald LE SCODAN, Nadine DOHOLLOU, Philippe DALIVOUST, Olivier Arsene, Nathalie MARQUES, Thierry Petit, Delphine MOLLON, Jérôme DAUBA, Nathalie BONNIN, François MORVAN, Miriam Gardner, Adina MARTI, Charles-Briac Levaché, Emma Lachaier, Mihaela ACHILLE, Christophe VALMAR, Ryan BOUAITA, Jacques Médioni, Cyril FOA, Chantal BERNARD-MARTY, Francesco Del Piano, Michel GOZY, Anne ESCANDE, Nicolas Leduc, Brigitte LUCAS, Dominique Mille, Hanifa AMMARGUELLAT, Abeer NAJEM, Fanny TROUBOUL, Philippe Barthélémy, Hervé DESCLOS, Didier Mayeur, Fabrice LORCHEL, François GUINET, Anne-Pascale Laurenty, Axelle BOUDRANT, Olivier GISSEROT, Corinne ALLEAUME, Aimery de Gramont,
In advanced oestrogen receptor-positive, HER2-negative breast cancer, acquired resistance to aromatase inhibitors frequently stems from ESR1-mutated subclones, which might be sensitive to fulvestrant. The PADA-1 trial aimed to show the efficacy of an early change in therapy on the basis of a rising ESR1 mutation in blood (bESR1mut), while assessing the global safety of combination fulvestrant and palbociclib.We did a randomised, open-label, phase 3 trial in 83 hospitals in France. Women aged at least ...
Tópico(s): Breast Cancer Treatment Studies
2022 - Elsevier BV | The Lancet Oncology
... pivotal role of gesture in the characterisation of Coraline, the central character in a stop-motion animation ... which was applied to analyse the deployment of Coraline's gesture during points of tension in the ...
Tópico(s): Language, Metaphor, and Cognition
2018 - Springer Nature | The Australian Journal of Language and Literacy
Elodie Long‐Mira, Marius Ilié, Emmanuel Chamorey, Florence Leduff-Blanc, H. Montaudié, Virginie Tanga, Maryline Allégra, Virginie Lespinet‐Fabre, Olivier Bordone, Christelle Bonnetaud, Renaud Schiappa, Catherine Butori, Coraline Bence, J.‐P. Lacour, Véronique Hofman, Paul Hofman,
... Bonnetaud 3 , Renaud Schiappa 4 , Catherine Butori 1 , Coraline Bence 1 , Jean-Philippe Lacour 5 , Véronique Hofman ...
Tópico(s): CAR-T cell therapy research
2018 - Impact Journals LLC | Oncotarget
Joseph R. Tumang, Bruno Gomes, Martin Wythes, Stefano Crosignani, Patrick Bingham, Pauline Bottemanne, Hélène Cannelle, Sandra Cauwenberghs, Jenny Chaplin, Deepak Dalvie, Sofie Denies, Coraline De Maeseneire, Peter Folger, Kim Frederix, Jie Guo, James C.H. Hardwick, Ken Hook, Katti Jessen, Erick Kindt, Marie-Claire Letellier, Kai‐Hsin Liao, Wenlin Li, Karen A. Maegley, Reece Marillier, Nichol Miller, Brion W. Murray, Romain Pirson, Julie Preillon, Virginie Rabolli, Chad Ray, Stephanie Scales, Jay Srirangam, Jim Solowiej, Nicole Streiner, Vince R. Torti, Konstantinos Tsaparikos, Paolo Vicini, Grégory Driessens, Manfred Kraus,
... Sandra Cauwenberghs, Jenny Chaplin, Deepak Dalvie, Sofie Denies, Coraline De Maeseneire, Peter Folger, Kim Frederix, Jie Guo, ...
Tópico(s): Pharmacological Receptor Mechanisms and Effects
2016 - American Association for Cancer Research | Cancer Research
... reach. This style, exemplified by Henry Selick's Coraline (2009) and Martin Scorsese's Hugo (2011), courts ...
Tópico(s): Shakespeare, Adaptation, and Literary Criticism
2012 - Indiana University Press | Film History
Elizabeth Parsons, Naarah Sawers, Kate McInally,
... psychoanalytic analysis of Neil Gaiman's junior novel Coraline and graphic novel The Mirror Mask in order ... of the two female protagonists of these novels, Coraline and Helena, as exemplars of maturational stages in ...
Tópico(s): Digital Games and Media
2008 - Johns Hopkins University Press | Children's Literature Association quarterly
... P. Craig Russell, who adapted Gaiman’s novel Coraline into a graphic novel. It is a faithful ... based on photographed models, which he employs in Coraline. This realistic treatment stands in contrast to the ... art accompanying the novel and in the movie, Coraline and the other characters are depicted in a ... so he clearly chose a realistic style for Coraline because he thought a realistic approach was better ...
Tópico(s): Themes in Literature Analysis
2015 - University of North Texas Press | Studies in the novel
... children's film, namely the split mothers in Coraline (2009). The argument for such a comparison is ...
Tópico(s): Themes in Literature Analysis
2015 - Taylor & Francis | Continuum
... animation, using as study case the animated film Coraline (Henry Selick, 2009), which incorporates different theories from ...
Tópico(s): Cinema History and Criticism
2011 - Technical University of Valencia | Con A de animación
Saeede Hosseinpour, Semnan Univer Nahid Shahbazi Department of English Language and Literature,
... features of magical realism within Neil Gaiman’s Coraline (2002) through the application of Wendy B. Faris’ ...
Tópico(s): Latin American Literature Analysis
2016 - De Gruyter Open | Prague Journal of English Studies
... being violated. (1) Scott Higgins' recent '3D Depth: Coraline, Hugo, and Sustainable Aesthetic' argues that while overt ... minded adults. (4) For Higgins, stop-motion animation Coraline (2009) is film that benefits from the of ... involved: though live-action, it is still, like Coraline, family horror film, with many special effects and ... things 3D. (8) The Hole, then, is, like Coraline, text that uses manner anchored to character experience. ( ...
Tópico(s): Shakespeare, Adaptation, and Literary Criticism
2012 - | Cineaction!
Darko Barišić, Christopher R. Chin, Cem Meydan, Matt Teater, Ioanna Tsialta, Coraline Mlynarczyk, Amy Chadburn, Xuehai Wang, Margot Sarkozy, Min Xia, Sandra E. Carson, Santo Raggiri, Sonia Dębek, Benedikt W. Pelzer, Ceyda Durmaz, Qing Deng, Priya Lakra, Martín A. Rivas, Christian Steidl, David W. Scott, Andrew P. Weng, Christopher E. Mason, Michael R. Green, Ari Melnick,
ARID1A, a subunit of the canonical BAF nucleosome remodeling complex, is commonly mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal center (GC) response, facilitating cooperative and sequential binding of PU.1 and NF-kB at crucial genes for cytokine and CD40 signaling. The absence of ARID1A tilts GC cell fate toward immature IgM+CD80−PD-L2− memory B cells, known for their potential to re-enter new GCs. When combined with BCL2 oncogene, ARID1A haploinsufficiency ...
Tópico(s): interferon and immune responses
2024 - Cell Press | Cancer Cell
Bradley J. Monk, Krishnansu S. Tewari, Coraline Dubot, M. Valeria Cáceres, Kosei Hasegawa, Ronnie Shapira‐Frommer, Pamela Salman, Eduardo Yañez, Mahmut Gümüş, Mivael Olivera, Vanessa Samouëlian, Vincent Castonguay, Arkhipov Alexander, Cumhur Tekin, Kan Li, Allison Martin Nguyen, Matthew Monberg, Nicoletta Colombo, Domenica Lorusso,
BackgroundIn the KEYNOTE-826 study, the addition of the anti-PD-1 monoclonal antibody pembrolizumab to chemotherapy with or without bevacizumab improved overall survival and progression-free survival (primary endpoints) versus placebo plus chemotherapy with or without bevacizumab, with manageable toxicity, in patients with persistent, recurrent, or metastatic cervical cancer. In this Article, we report patient-reported outcomes (PROs) from KEYNOTE-826.MethodsKEYNOTE-826 is a multicentre, randomised, ...
Tópico(s): Endometrial and Cervical Cancer Treatments
2023 - Elsevier BV | The Lancet Oncology
Krishnansu S. Tewari, Nicoletta Colombo, Bradley J. Monk, Coraline Dubot, M. Valeria Cáceres, Kosei Hasegawa, Ronnie Shapira‐Frommer, Pamela Salman, Eduardo Yáñez, Mahmut Gümüş, Mivael Olivera, Vanessa Samouëlian, Vincent Castonguay, Alexander Arkhipov, Cumhur Tekin, Kan Li, Sarper Toker, Stephen J. O’Keefe, Domenica Lorusso,
The KEYNOTE-826 randomized clinical trial showed statistically significant and clinically meaningful survival benefits with the addition of pembrolizumab to chemotherapy with or without bevacizumab in patients with persistent, recurrent, or metastatic cervical cancer. Treatment effects in patient subgroups of the study population are unknown.
Tópico(s): Cervical Cancer and HPV Research
2023 - American Medical Association | JAMA Oncology
Félix Blanc‐Durand, Elisa Yaniz‐Galende, Alba Llop‐Guevara, Catherine Genestie, Violeta Serra, Andrea Herencia-Ropero, Christophe Klein, Dominique Berton, Alain Lortholary, Nadine Dohollou, Christophe Desauw, Michel Fabbro, Emmanuelle Malaurie, Nathalie Bonichon-Lamaichhane, Coraline Dubot, Jean Emmanuel Kurtz, Gaëtan De Rauglaudre, Nadia Raban, Annick Chevalier-Place, Gwénaël Ferron, Marie‐Christine Kaminsky, Claire J.H. Kramer, Étienne Rouleau, Alexandra Léary,
Rationale Homologous recombination deficiency (HRD), defined as BRCA1/2 mutation (BRCAmut) or high genomic instability, is used to identify ovarian cancer (OC) patients most likely to benefit from PARP inhibitors. While these tests are useful, they are imperfect. Another approach is to measure the capacity of tumor cells to form RAD51 foci in the presence of DNA damage using an immunofluorescence assay (IF). We aimed to describe for the first time this assay in OC and correlate it to platinum response ...
Tópico(s): DNA Repair Mechanisms
2023 - Elsevier BV | Gynecologic Oncology
Domien Vanneste, Qiang Baï, Shakir Hasan, Peng Wen, Dimitri Pirottin, Joey Schyns, Pauline Maréchal, Cecilia Ruscitti, Margot Meunier, Zhaoyuan Liu, Céline Legrand, Laurence Fiévez, Florent Ginhoux, Coraline Radermecker, Fabrice Bureau, Thomas Marichal,
Abstract Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct niches and exert important tissue-supportive functions. RTM maintenance is thought to rely either on differentiation from monocytes or on RTM self-renewal. Here, we used a mouse model of inducible lung interstitial macrophage (IM) niche depletion and refilling to investigate the development of IMs in vivo. Using time-course single-cell RNA-sequencing analyses, bone marrow chimeras and gene targeting, ...
Tópico(s): Extracellular vesicles in disease
2023 - Nature Portfolio | Nature Immunology
Frederic Brosseron, Anne Maaß, Luca Kleineidam, Kishore Aravind Ravichandran, Carl‐Christian Kolbe, Steffen Wolfsgruber, Francesco Santarelli, Lisa M. Häsler, Róisín M. McManus, Christina Ising, Sandra Röske, Oliver Peters, Nicoleta Carmen Cosma, Luisa‐Sophie Schneider, Xiao Wang, Josef Priller, Eike J. Spruth, Slawek Altenstein, Anja Schneider, Klaus Fließbach, Jens Wiltfang, Björn H. Schott, Katharina Büerger, Daniel Janowitz, Martin Dichgans, Robert Perneczky, Boris‐Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Görß, Christoph Laske, Matthias H. Munk, Emrah Düzel, Renat Yakupow, Laura Dobisch, Coraline D. Metzger, Wenzel Glanz, Michael Ewers, Peter Dechent, John–Dylan Haynes, Klaus Scheffler, Nina Roy, Ayda Rostamzadeh, Annika Spottke, Alfredo Ramı́rez, David Mengel, Matthis Synofzik, Mathias Jucker, Eicke Latz, Frank Jessen, Michael Wagner, Michael T. Heneka,
Abstract Background Neuroinflammation constitutes a pathological hallmark of Alzheimer’s disease (AD). Still, it remains unresolved if peripheral inflammatory markers can be utilized for research purposes similar to blood-based beta-amyloid and neurodegeneration measures. We investigated experimental inflammation markers in serum and analyzed interrelations towards AD pathology features in a cohort with a focus on at-risk stages of AD. Methods Data of 74 healthy controls (HC), 99 subjective cognitive ...
Tópico(s): Dementia and Cognitive Impairment Research
2023 - BioMed Central | Alzheimer s Research & Therapy
Éric Pujade-Lauraine, Frédèric Selle, Giovanni Scambia, Bernard Asselain, Frederik Marmé, Kristina Lindemann, Nicoletta Colombo, Radosław Mądry, Rosalind Glasspool, Ignace Vergote, Jacob Korach, S. Lheureux, Coraline Dubot, Ana Oaknin, Claudio Zamagni, Florian Heitz, Laurence Gladieff, María Jesús Rubio-Pérez, Paolo Scollo, Christopher Blakeley, Brian Shaw, I. Ray-Coquard, Andrés Redondo,
Poly(ADP-ribose) polymerase (PARP) inhibitor maintenance therapy is the standard of care for some patients with advanced ovarian cancer. We evaluated the efficacy and safety of PARP inhibitor rechallenge.
Tópico(s): BRCA gene mutations in cancer
2023 - Elsevier BV | Annals of Oncology
I. Ray-Coquard, Alexandra Léary, Sandro Pignata, Claire Cropet, Antonio González‐Martín, Christian Marth, Shoji Nagao, Ignace Vergote, Nicoletta Colombo, Johanna Mäenpää, Frédèric Selle, Jalid Sehouli, Domenica Lorusso, Eva Maria Guerra Alía, Gerhard Bogner, Hiroyuki Yoshida, C. Lefeuvre-Plesse, Paul Buderath, Anna Maria Mosconi, A. Lortholary, Alexander Burges, J. Medioni, Ayşe Balat, Manuel Rodrigues, Tjoung‐Won Park‐Simon, Coraline Dubot, Dominik Denschlag, Benoît You, Éric Pujade-Lauraine, Philipp Harter,
•First PARPi trial to show clinically meaningful OS benefit in HRD+ (BRCA/non-BRCA) newly diagnosed advanced ovarian cancer.•5-Year OS rate in HRD+ disease was 66% with olaparib + bevacizumab versus 48% with placebo + bevacizumab.•Forty-six percent of HRD+ patients receiving olaparib + bevacizumab were progression free at 5 years, versus 19% on bevacizumab alone.•No new safety signals were observed, and the incidence of myelodysplastic syndrome/acute myeloid leukemia remained low.•Maintenance olaparib + ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2023 - Elsevier BV | Annals of Oncology