Catherine Pirard, Patrice Dufour, Corinne Charlier,
The few Belgian studies on the human exposure to perfluoroalkyl substances (PFASs) have until now concerned the Northern part of Belgium (Flanders), while data related to Wallonia (South region) are missing. To fill this gap, 8 perfluorinated carboxylic acids and 3 perfluorinated alkyl sulfonates were measured in the serum of 242 adults (>18 years old) recruited in 2015 and living in the Province of Liege. Some multivariate regression models were also built with the PFAS levels and the participant's ...
Tópico(s): Air Quality and Health Impacts
2020 - Elsevier BV | Toxicology Letters
Yvann Bourigault, Sophie Rodrigues, Alexandre Crépin, Andréa Chane, Laure Taupin, Mathilde Bouteiller, Charly Dupont, Annabelle Mérieau, Yoan Konto‐Ghiorghi, Amine M. Boukerb, Marie Turner, Céline Hamon, Alain Dufour, Corinne Barbey, Xavier Latour,
Biofilms are complex structures formed by a community of microbes adhering to a surface and/or to each other through the secretion of an adhesive and protective matrix. The establishment of these structures requires a coordination of action between microorganisms through powerful communication systems such as quorum-sensing. Therefore, auxiliary bacteria capable of interfering with these means of communication could be used to prevent biofilm formation and development. The phytopathogen Rhizobium ...
Tópico(s): Cystic Fibrosis Research Advances
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Cyrille Robert, Anne Soulier, Didier Sciard, Guillaume Dufour, Corinne Alberti, Priscilla Boizeau, Marc Beaussier,
The Aldrete's score is used to determine when a patient can safely leave the Post-Anaesthesia Care Unit (PACU) and be transferred to the surgical ward. The Aldrete score is based on the evaluation of vital signs and consciousness. Cognitive functions according to the anaesthetic strategy at the time the patient is judged fit for discharge from the PACU (Aldrete's score ≥ 9) have not been previously studied. The aim of this trial was to assess the cognitive status of inpatients emerging either from desflurane ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2021 - BioMed Central | BMC Anesthesiology
Clémence Dubois, Robin Dufour, Pierre Daumar, Corinne Aubel, Claire Szczepaniak, Christelle Blavignac, Emmanuelle Mounetou, Frédérique Penault‐Llorca, Mahchid Bamdad,
Clémence Dubois1,2, Robin Dufour1,2, Pierre Daumar1, Corinne Aubel3, Claire Szczepaniak4, Christelle Blavignac4, Emmanuelle Mounetou1,*, Frédérique Penault-Llorca2,* and Mahchid Bamdad1,5 1Université Clermont Auvergne, Institut Universitaire de Technologie, INSERM, U1240, Imagerie Moléculaire et Stratégies Théranostiques, F-63000 Clermont Ferrand, France 2Université Clermont Auvergne, Centre Jean Perrin, INSERM, U1240, Imagerie Moléculaire et Stratégies Théranostiques, F-63000 Clermont Ferrand, ...
Tópico(s): Pluripotent Stem Cells Research
2017 - Impact Journals LLC | Oncotarget
Patrice Dufour, Catherine Pirard, Corinne Charlier,
Many in vitro or in vivo studies highlighted the potential deleterious effects of phenolic organohalogenated compounds (POHs) on the health, particularly on the thyroid system homeostasis, however few large scale human epidemiological studies have been carried out, especially in Europe. Further studies monitoring the human contamination by POHs, the sources of exposure and the influence of these compounds on thyroid health are still needed. Therefore we determined the concentrations of 16 POHs (pentachlorophenol ( ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2017 - Elsevier BV | The Science of The Total Environment
Patrice Dufour, Catherine Pirard, Corinne Charlier,
Over the last decades, more and more studies focused on the impact of endocrine disruptors on the environment and human health. Among them, phenolic organohalogens (POHs) are a particular concern because of their structural resemblance with natural hormones. There are different methods that are known to quantify these compounds in human serum, however, the current extraction techniques are long, fastidious and using harmfull chemicals such as diazomethane and sulfuric acid. Consequently, we developed ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2016 - Elsevier BV | Journal of Chromatography B
Sophie Béraud-Dufour, Romain Gautier, Corinne Albigès‐Rizo, Pierre Teilhard de Chardin, Eva Faurobert,
The small G protein Rap1 regulates diverse cellular processes such as integrin activation, cell adhesion, cell-cell junction formation and cell polarity. It is crucial to identify Rap1 effectors to better understand the signalling pathways controlling these processes. Krev interaction trapped 1 (Krit1), a protein with FERM (band four-point-one/ezrin/radixin/moesin) domain, was identified as a Rap1 partner in a yeast two-hybrid screen, but this interaction was not confirmed in subsequent studies. As ...
Tópico(s): Cellular transport and secretion
2007 - Wiley | FEBS Journal
Christelle Girard, Alexis‐Pierre Bemelmans, Noëlle Dufour, Jacques Mallet, Corinne Bachelin, Brahim Nait‐Oumesmar, Anne Baron‐Van Evercooren, F. Lachapelle,
Experimental studies provided overwhelming proof that transplants of myelin-forming cells achieve efficient remyelination in the CNS. Among cellular candidates, Schwann cells can be used for autologous transplantation to ensure robust remyelination of lesions and to deliver therapeutic factors in the CNS. In the present study, macaque Schwann cells expressing green fluorescent protein (GFP) were infected with human immunodeficiency virus-derived vectors overexpressing brain-derived neurotrophic factor ( ...
Tópico(s): Hereditary Neurological Disorders
2005 - Society for Neuroscience | Journal of Neuroscience
Corinne Findeling-Dufour, A. Gicquel, R. Chiron,
In a previous work, the possibility of making large area single crystal diamond layers on top of mosaics formed by two to seven pieces of natural diamonds using MPACVD was demonstrated. The choice of adequate crystallographic orientation of the diamond faces, as well as the identification of the key growth parameters which control the growth mechanism, has lead to the realization of single crystal layers at the junction of adjacent crystals. Although these parameters are necessary, a deeper analysis ...
Tópico(s): Solidification and crystal growth phenomena
1998 - Elsevier BV | Diamond and Related Materials
Corinne Findeling-Dufour, A. Gicquel,
A study on the feasibility of a process for making large area diamond, single-crystalline films using a microwave plasma assisted chemical vapour deposition reactor is presented. After choosing the (100) orientation for the seed crystals' top faces, the operating conditions of the plasma reactor were optimised in such a way that step flow mechanism or two-dimensional nucleation mechanism can be favoured. To prevent the development of facets at the crystal edges, (100) orientation was chosen for side ...
Tópico(s): Metal and Thin Film Mechanics
1997 - Elsevier BV | Thin Solid Films
Corinne Findeling-Dufour, Alexis Vignes, A. Gicquel,
Homoepitaxial diamond layers were grown in a microwave plasma-assisted chemical vapour deposition (MWPACVD) reactor on {100} and {110} diamond single crystals. The effects of the operating conditions and of the substrate misorientation from a low index plane on the quality of the epi layers and on the growth rates are presented. Optical and scanning electron microscopy demonstrated that, for the {100} substrates, the morphology of the layers strongly depends on the substrate temperature and on the microwave ...
Tópico(s): Advanced materials and composites
1995 - Elsevier BV | Diamond and Related Materials
Dominique Figarella‐Branger, H. Dufour, Carlos Sánchez Fernández, Corinne Bouvier‐Labit, F. Grisoli, J. F. Pellissier,
Tópico(s): Tumors and Oncological Cases
2002 - Springer Science+Business Media | Acta Neuropathologica
Mouhamad Ali Ahmad, Bénédicte Prelot, Angélina Razafitianamaharavo, J. M. Douillard, Jerzy Zając, Fabien Dufour, Olivier Durupthy, Corinne Chanéac, Frédéric Villièras,
Various titanium dioxide nanoparticles were prepared by sol–gel method in order to obtain samples showing different sizes and morphologies. An original approach based on the adsorption of gaseous molecules from the gas phase was proposed to gain information about surface energy of nanosized TiO2 anatase in terms of interfacial reactivity and heterogeneity. Argon, nitrogen, and ammonia were selected as such surface molecular probes. The mainly observed crystallographic faces of anatase particles ...
Tópico(s): Gas Sensing Nanomaterials and Sensors
2012 - American Chemical Society | The Journal of Physical Chemistry C
Robin Dufour, Pierre Daumar, Emmanuelle Mounetou, Corinne Aubel, Fabrice Kwiatkowski, Catherine Abrial, Catherine Vatoux, Frédérique Penault‐Llorca, Mahchid Bamdad,
Abstract The triple negative basal-like (TNBL) breast carcinoma is an aggressive and unfavorable prognosis disease. Inhibitors of poly(ADP-ribose) polymerase such as Olaparib could represent a promising targeted therapy but their sensitivity against Multidrug Resistance proteins (MDR), which causes resistance, is not well defined. Thus, our work focused on the analysis of P-gp and BCRP coexpression in the SUM1315 TNBL human cell line, in correlation with Olaparib intracellular concentration. Western ...
Tópico(s): Cell death mechanisms and regulation
2015 - Nature Portfolio | Scientific Reports
Fabien Dufour, Barbara Fresch, Olivier Durupthy, Corinne Chanéac, F. Remacle,
The catalytic, electrochemical, and optical properties of gold clusters and small nanoparticles depend on the cluster size, on the nature of the ligand shell and on the solvent environment. The structural and electronic properties of the neutral and trication bare cluster Au11 are investigated using density functional theory. We focus on the influence of the cluster charge, the solvent, and the nature and number of the ligands (thiol, thiolate, thiyl radical, phosphine, chloride, and chlorine) on ...
Tópico(s): Quantum Dots Synthesis And Properties
2014 - American Chemical Society | The Journal of Physical Chemistry C
Delphine Body-Bechou, Philippe Loget, Dominique D’Hervé, Bernard Le Fiblec, Anne-Gaelle Grébille, Hélène Le Guern, Caroline Labarthe, Margaret Redpath, Anne-Sophie Cabaret-Dufour, Sylvie Odent, Alice Fiévet, Corinne Antignac, Laurence Heidet, Sophie Taque, P. Poulain,
The aim of this study was to document the association between pancreatic agenesis or hypoplasia and multicystic renal dysplasia related to transcription factor 2 (TCF2) or hepatocyte nuclear factor 1 beta mutations.We describe the phenotype of the pancreas and the kidneys from three fetuses heterozygous for a mutation of TCF2.Case 1 had bilateral hyperechogenic, multicystic kidneys, bilateral clubfoot and pancreatic agenesis. Case 2 had two enlarged polycystic kidneys, anamnios and pancreatic agenesis. ...
Tópico(s): Congenital Diaphragmatic Hernia Studies
2013 - Wiley | Prenatal Diagnosis
Thierry Dufour, Julie Hubert, Pascal Viville, Corinne Duluard, Simon Desbief, Roberto Lazzaroni, François Reniers,
Abstract The texturization of poly(tetrafluoroethylene) (PTFE) surfaces is achieved at atmospheric pressure by using the post‐discharge of a radio‐frequency plasma torch supplied in helium and oxygen gases. The surface properties are characterized by contact angle measurement, X‐ray photoelectron spectroscopy and atomic force microscopy. We show that the plasma treatment increases the surface hydrophobicity (with water contact angles increasing from 115 to 155°) only by modifying the PTFE surface ...
Tópico(s): Plasma Applications and Diagnostics
2012 - Wiley | Plasma Processes and Polymers
Ludivine Fadel, C. Zimmermann, Isabelle Dufour, Corinne Déjous, D. Rebière,
The objective of this paper is to couple theoretical and experimental results from microcantilevers and Love-wave acoustic devices in order to identify and separate mass loading effects from elastic effects. This is important in the perspective of sensing applications. For that, a thin-film polymer is deposited on both resonant platforms. It is demonstrated that microcantilevers are essentially mass sensitive. They allow one to determine the polymer layer thickness, which is validated by optical ...
Tópico(s): Analytical Chemistry and Sensors
2005 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control
Patrice Dufour, Catherine Pirard, Marie-Christine Seghaye, Corinne Charlier,
The last decades have seen the increasing prevalence of thyroid disorders. These augmentations could be the consequence of the increasing contamination of the environment by chemicals that may disrupt the thyroid function. Indeed, in vitro studies have shown that many chemicals contaminating our environment and highlighted in human serum, are able to interfere with the thyroid function. Given the crucial importance of thyroid hormones on neurodevelopment in fetus and newborns, the influence of these ...
Tópico(s): Per- and polyfluoroalkyl substances research
2018 - Elsevier BV | Environmental Pollution
Corinne Duluard, Thierry Dufour, Julie Hubert, François Reniers,
The influence of ambient air on the flowing afterglow of an atmospheric pressure Ar/O2 radiofrequency plasma has been investigated experimentally. Spatially resolved mass spectrometry and laser induced fluorescence on OH radicals were used to estimate the intrusion of air in between the plasma torch and the substrate as a function of the torch-to-substrate separation distance. No air is detected, within the limits of measurement uncertainties, for separation distances smaller than 5 mm. For larger ...
Tópico(s): Plasma Diagnostics and Applications
2013 - American Institute of Physics | Journal of Applied Physics
Patrice Dufour, Corinne Charlier,
Since Antiquity, men have used chemicals to protect their goods against fire. Effective and easy to use, brominated flame retardants are used since decades massively in plastic industry. Such like other organohalogenated compounds, brominated flame retardants are very persistent in the environment and able to accumulate along the food chain. Many authors highlight their presence in the environment, in many animal species and in the human serum. Worryingly, man is exposed as soon as the pregnancy ...
Tópico(s): Toxic Organic Pollutants Impact
2017 - John Libbey Eurotext | Annales de biologie clinique
Patrice Dufour, Catherine Pirard, Patrick Pétrossians, Albert Beckers, Corinne Charlier,
Previous years, the incidence of autoimmune thyroid diseases has increased worldwide. The presence of many pollutants in the environment suspected to be thyroid disruptors may have contributed to the observed increase. Unfortunately, the results from epidemiological studies assessing the association between pollution and thyroid disorders remain inconsistent, maybe due to a nearly complete neglect of the mixture effect. The blood levels of 12 brominated flame retardants, 3 polychlorinated biphenyls, ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2019 - Elsevier BV | Environmental Research
Ramahefarizo Rasolonjanahary, Corinne Gérard, Marie-Noëlle Dufour, Vincent Homburger, A Enjalbert, Gilles Guillon,
Dopamine (DA) is known to inhibit basal and hormone TRH- or angiotensin II (AngII)-stimulated PRL secretion and inositol phosphate accumulation in rat pituitary cells in primary culture. This inhibition persists when cells are incubated in a calcium-free medium (a condition in which DA could not inhibit PLC activities by blocking calcium influx) and is abolished by a Pertussis toxin treatment. These data suggest that DA receptor could be negatively coupled to PLC by a direct mechanism involving a Pertussis ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2002 - Oxford University Press | Endocrinology
Mouhamad Ali Ahmad, Bénédicte Prelot, Fabien Dufour, Olivier Durupthy, Angélina Razafitianamaharavo, J. M. Douillard, Corinne Chanéac, Frédéric Villièras, Jerzy Zając,
The aim of this study was to provide new insight into the evaluation of the effect of the crystallinity, size, and morphology of TiO2-anatase nanoparticles on their acid–base properties at the solid–liquid interface. This was achieved through monitoring the evolution in the surface charge density with the solution acidity and point of zero net proton charge (PZNPC) for a set of anatase nanoparticles with a mean size in the 5–20 nm range and various shapes. Different anatase nanoparticles were obtained ...
Tópico(s): Iron oxide chemistry and applications
2013 - American Chemical Society | The Journal of Physical Chemistry C
Julie Dufour, Aurélien Pommier, Georges Alves, Hugues de Boussac, Corinne Lours-Calet, David H. Volle, Jean‐Marc A. Lobaccaro, Silvère Baron,
Recent studies underline the implication of Liver X Receptors (LXRs) in several prostate diseases such as benign prostatic hyperplasia (BPH) and prostate cancer. In order to understand the molecular mechanisms involved, we derived epithelial cells from dorsal prostate (MPECs) of wild type (WT) or Lxrαβ−/− mice. In the WT MPECs, our results show that LXR activation reduces proliferation and correlates with the modification of the AKT-survival pathway. Moreover, LXRs regulate lipid homeostasis with the ...
Tópico(s): Steroid Chemistry and Biochemistry
2013 - Public Library of Science | PLoS ONE
Fabien Dufour, Sophie Cassaignon, Olivier Durupthy, Christophe Colbeau‐Justin, Corinne Chanéac,
Abstract Microwave‐assisted synthesis represents a valuable improvement in the domains of molecular and organic chemistry and was recently extended to inorganic and materials chemistry. A comparison of titanium dioxide nanoparticles synthesised in aqueous solution prepared in a microwave or a conventional oven is presented here. More precisely, three different protocols were used in order to determine the impact of the heating mode on the final product in terms of crystalline structure, particle ...
Tópico(s): Nanomaterials for catalytic reactions
2012 - Wiley | European Journal of Inorganic Chemistry
Philippe Métellus, Mehdi Laghmari, S. Fuentès, Alexandre Eusébio, T. Adetchessi, Stéphane Ranque, Corinne Bouvier, Henry Dufour, F. Grisoli,
Cerebral mucormycosis without rhino-orbital or systemic involvement is an extremely rare condition mostly associated with parenteral drug abuse. We report the case of a 42-year-old woman who presented with hemiparesis of the left side and altered mental status. Neuroradiologic workup demonstrated an inflammatory lesion involving the right basal ganglia. Proton magnetic resonance spectroscopy demonstrated features consistent with a pyogenic abscess. Computed tomography–guided stereotactic biopsy ...
Tópico(s): Fungal Infections and Studies
2007 - Elsevier BV | Surgical Neurology
Yannick Charretier, Olivier Dauwalder, Christine Franceschi, Elodie Degout-Charmette, Gilles Zambardi, Tiphaine Cecchini, Chloé Bardet, Xavier Lacoux, Philippe Dufour, Laurent Véron, Hervé Rostaing, Véronique Lanet, Tanguy Fortin, Corinne Beaulieu, Nadine Perrot, Dominique Dechaume, Sylvie Pons, Victoria Girard, Arnaud Salvador, G. Durand, Frédéric Mallard, Alain Théretz, Patrick Broyer, Sonia Chatellier, Gaspard Gervasi, Marc van Nuenen, Carolyn Roitsch, Alex van Belkum, Jérôme Lemoine, François Vandenesch, Jean‐Philippe Charrier,
Mass spectrometry (MS) in Selected Reaction Monitoring (SRM) mode is proposed for in-depth characterisation of microorganisms in a multiplexed analysis. Within 60-80 minutes, the SRM method performs microbial identification (I), antibiotic-resistance detection (R), virulence assessment (V) and it provides epidemiological typing information (T). This SRM application is illustrated by the analysis of the human pathogen Staphylococcus aureus, demonstrating its promise for rapid characterisation of bacteria ...
Tópico(s): Antibiotic Resistance in Bacteria
2015 - Nature Portfolio | Scientific Reports
Laurana Serres-Giardi, Jean Dufour, Karen Russell, Corinne Buret, F. Laurens, Frédérique Santi,
Research of triploid individuals was carried out in the French wild cherry ( Prunus avium L.) collection at the Institut National de la Recherche Agronomique (INRA), Orléans, France, using 12 microsatellite markers and the S gametophytic incompatibility marker. For 11 of 312 clones (3.5%), we found three different alleles or two different alleles included one doubled allele for 10–12 markers spread along five of the eight chromosome pairs in wild cherry. The cytometry analysis confirmed that triploidy ...
Tópico(s): Plant Molecular Biology Research
2010 - NRC Research Press | Canadian Journal of Forest Research
Gérald Bertrand, Vincent Jallu, T. Beranger, Frédéric Bianchi, C Casale, Vinciane Dufour, Christophe Chenet, J. Quesne, Corinne Martageix, C. Kaplan,
Background and Objectives In fetal/neonatal thrombocytopenia, maternal alloimmunization is diagnosed by the identification of the maternal alloantibody and the offending paternal antigen inherited by the foetus/neonate. Today, for practical reasons, most laboratories perform platelet genotyping instead of phenotyping. Here, we report the case of a human platelet antigen ( HPA )‐5 genotype/phenotype discrepancy observed in a mother who delivered a mildly thrombocytopenic newborn. Materials and methods ...
Tópico(s): Blood disorders and treatments
2013 - Wiley | Vox Sanguinis