Giles Smith, Richard Mabey, Andrew Robson, Lemon Grass, Phil Yates, Christina Hardyment, John McNamara, Rosemary Righter, Cath Urquhart, Colin Firth, Donald MacGillivray, Robert Cole, Josie Appleton, Zahid Hussain, Nigel Colborn, Sarah Potter, Ian Nathan, Simon Barnes, Alan Blyth, Tim De Lisle, Magnus Linklater, Simon Hills, David Powell Athietics Correspondent, Paul Hoggart, Richard Hobson, John Mulvey, Clare Lazaro, Mark Sutherland, Michael Evans Defence Editor, Philip Howard, Lindsay Hoyle, John Simpson, Oilver Kay, Christine Seib, Anthony Horowitz, Michael Binyon, Patrick Millard, Brendan Commons, Clive Davis, Richard Hobson One-Day Cricket Correspondent, Elizabeth Judge, Patrick Kidd, Gillian Harris Scotland Correspondent, Richard Eaton, Morag Preston, Theo Hobson, James Hider, Roger Maynard, Jeremy Whittle, Kevin Eason, Stuart Turnbull, Anthony H. Ratcliffe, Geoff Brown, Tim Howard, Sam Lister, James Jolly, Giles Coren, Andrew Norfolk, Louise Parkes, Alastair Campbell, Clare Stewart, Antonia Senior, Rosie Millard, K. R. Jones, Ben Webster Transport Correspondent, SC, Pat Gibson, Anthony Loyd and Richard Mills, David McVay, Nancy Durrant, Georgia Glynn Smith, Hilary Rose, Katherine Swift, Dave Robinson, Anne Enright, Dominic Walsh, Debra Craine, Gary Jacob, Joe Morgan, J. A. Pitts, Tim Reid, Grainne Gilmore, Angela Jameson Industrial Correspondent, Dr Jane Collins, Craig …, Dalya Alberge Arts Correspondent, Richard Ford Home Correspondent, Jo Morris, Paul Reeve, Stephen Farrell, Alan Hamilton, Jenny MacArthur, Roger Deakin, Patrick Ridd, Ron Lewis, Martin Symington, Helen Rumbelow, Stefanie Marsh, Matt Dickinson Chief Football Correspondent, Genevieve Fox, Tim Teeman, Matthew Pinsent, Caroline Merrell Banking Correspondent, Derwent May, Arwa Haider, Angela Jameson, Ivan Hewett, Reg Andlaw, Aggie MacKenzie, Russell Kempson, Peter Paphides, Daniel McGrory, Tony Halpin Education Editor, Oliver Kay, Richard Cork, Gerard Baker, Stephen Anderton, Jerome Burne, Ed Potton, Ian McLntyre, Stevie Chick, Amber Cowan, Mark Atherton, Jonah Goldberg, John Westerby, Jack Shamash, Lisa Armstrong, PC, Sarah Vine, Jill Sherman Whitehall Editor, Holly Finn, Christopher Martin-Jenkins, James Doran and Daniel McGrory, Chris Power, Rob Wright, Nic Hopkins and Dan Sabbagh, Elaine Monaghan, Amanada Craig, Amanda Platell, Stuart Miles, Peter Tatlow, Benjamin Fry, David Powell Athletics Correspondent, Gavin Martin, Raymond Keene, Suzi Godson, Matthew Pryor, Rod Liddle, Sean MacAulay, Fiona Morrow, Keith Padbury, Peter Stothard, Scott Capurro, Stephen Reicher, Paula Hawkins Deputy Personal Finance Editor, Chris Campling, Ken Kirk, Clive Cheesman, Helen Rumbelow Political Correspondent, Cathy Harris, Daniel McGrory, Adam Fresco and Richard Ford, Helen Nugent, Richard Owen, Christopher Martin-Jenkins Chief Cricket Correspondent, Alex Hawkes, Roger Boyes, Adam Fresco and Elaine Monaghan, Hugh Peskett, David Terry, Chloë Bryan-Brown, Ruth Scurr, Frank Egerton, Victoria O'brien, Julian Muscat, Nigel Wiliamson, Roger Moore, Mike Mulvihill, John Harvey, Nigel Kendall, Andrew Clennell, Maureen Shaw, John Goodbody, Tosin Sulaiman, Robert Crampton, Julie Burchill, Craig Lord, Mike Berry, Matthew Parris, George Caulkin, Mike Barnard, Jonathan Rendall, Tim Wapshott, Russell Jenkins, Caitlin Moran, Peter Riddell, Helen Pridham, Eric Ellis, Steph Cook, Keith Darby, Richard Beeston Diplomatic Editor, David Charter Chief Political Correspondent, Jo Monroe, Carola Long, Graham Searjeant, John Naish, Lea Paterson, Hattie Ellis, Mark Henderson, Chris Ayres, Christopher Irvine, Mark Cocker, Carl Mortished International Business Editor, Laura Peek, Benedict Nightingale, Martyn Sharpe, Angus Batey, Anne Deniau, Stephen Dalton, Jill Crawshaw, Robert Powell, Leo Lewis, Richard Morrison, David Powell, Tom Chesshyre, Paul Connolly, James Christopher, Michael Henderson, Simon Crompton, Alan Jackson, Alexandra Blair Education Correspondent, Ben Blackmore, Edward Gorman Sailing Correspondent, Ed Gorman, Sam Lister Health Correspondent, Joe Bolger, Lisa Verrico, Joan Smith, David Lister Ireland Correspondent,
... Pressure Points The Science of Stress Heart Rate Cortisol Levels Hole lot of love Bank managers get ...
2004 - Gale Group | TDA
SUMMARY Some metabolic effects of cortisol were investigated in non-pregnant ewes fed either ad lib . or on a restricted ration. Cortisol (25 mg./day) administered for a period of ... ewes offered food ad lib . Higher levels of cortisol (50 and 75 mg./day) administered for similar ... on voluntary food intake, but an even greater cortisol dose (150 mg./day) resulted in a marked ... did not refuse food at any time during cortisol administration. Urinary nitrogen excretion was increased during cortisol administration but sequential increases in the cortisol dose ...
Tópico(s): Effects of Environmental Stressors on Livestock
1963 - Bioscientifica | Journal of Endocrinology
Giles Smith, Andrew Robson, Marion McGilvary, Nick Wadhams, Lizzy Melless, Andrew Billen, Miranda McLachlan, David Brown, Leo Lewis Asia Business Correspondent, Alan M. Pardoe, Fay Mansell Chair, Tom Dyckhoff, David Aaronovitch, Robin Pagnamenta Energy and Environment Editor, David Wighton Business Editor, Robert Lindsay, Linda Tsang, M. R. D. Foot, Alexandra Frean Education Editor, Judith Susser, Philip Howard, David Pannick, Christine Seib, David Chater, Charles Tilley chief executive, James Bone, James Ducker, Murad Ahmed, Clive Davis, Kevin Crowley, Carl Mortished, Will Pavia, Kevin Eason, Geoff Brown, Lucy Bannerman, Sally Hunt, Joe Joseph, Kate Rutherford, David Sharrock, Pat Gibson, Stan Fisher, Donald Hutera, Steve Keenan, Siobhan Kennedy, Francis Elliott, Deborah Haynes, Jack Malvern, Dominic Walsh, Tom Bawden, Father Barrie Senior, Gary Jacob, Mark Jones, Peter Stiff, Tim Reid, Libby Purves, Melanie Angel, Baroness Kennedy, Karen Bartlett, Sean O'Neill Crime & Security Editor, Charles Bremner, Michael Glover, Jamie Walker, Helen Rumbelow, Stefanie Marsh, Hugo Rifkind, Derwent May, Lord Dholakia, Abby Jan Dharamsey, Edward Fennell, Gary Duncan Economics Editor, Oliver Kay, Gerard Baker, Ross Clark, Mark Henderson Science Editor, Professor Joanna Bourke, Patrick Arbuthnot, James Rossiter, Scott Rutherford, Douglas Rankine, David Robertson Business Correspondent, John Hopkins Golf Correspondent, Rob Wright, Raymond Keene, Crispin A. Shorter, Christine Buckley, Matthew Pryor, Matt Dickinson, Matt Hughes, Baroness Corston, Paul Collier, Jeremy Page, Richard Owen, Francesca Steele, Francis Elliott Deputy Political Editor, David Akenhead, David Hands Rugby Correspondent, Paul Simons, Major Anthony Hollis, Roger W. Powell, Gerard Baker US Editor, Sam Coates Chief Political Correspondent, Tom King, Thomas Catán, Emily Ford, Dominic Maxwell, Lyndon B. Johnson, Alan Lee, Peter Riddell, Michael Gove, Nick Clegg, Professor Richard M. S. Wilson, Rajeev Syal, Philip Webster, Dr Nicole Westmarland Chair, David Sanderson, David Sinclair, Chris Ayres, Veronica Schmidt, Simon Duffin, G. F. Read Cardiff, Paul Larter, Rick Broadbent Athletics Correspondent, Stephen Dalton, Dr Katherine Rake Director, Nicola Woolcock, Michael Evans, Gareth Walton director, Olav Bjortomt, Clare Short, MP, Miles Costello, Nicola Copping, Jane Wild, David Robertson, Stuart A. Blackwell, Oliver Reichardt research officer, Lisa Verrico,
... crunch Higher testosterone levels lead to risk-taking Cortisol may induce the opposite effect Multiple Display Advertising ...
2008 - Gale Group | TDA
John E. Plager, Robert H. Knopp, W. Roy Slaunwhite, Avery A. Sandberg,
Cortisol binding by dog plasma was studied by ultrafiltration and equilibrium dialysis techniques and was compared to ... 3) the effect of estrogen administration on the cortisol-binding properties of the plasma. The resting plasma cortisol level in the dog is below 2 μg/ ... level, by ultrafiltration analysis, about 88% of the cortisol is bound. At a plasma level of 10 μg/100 ml, 67% of the cortisol is bound and at 100 μg/100 ml, ... dog albumin solution binds about 50% of the cortisol. Human transcortin is inactivated by heating the plasma ...
Tópico(s): Hormonal Regulation and Hypertension
1963 - Oxford University Press | Endocrinology
Tara Palmer-Tomkinson's, John de Visser, Michael Prescott, Rhoda Koenig, Matthew Wall, Barbara Hall, Christopher Morgan Religious Affairs Correspondent, Bruce McWilliams, Mrs D Crow, John Crawley, Jim Munro, John Peter, Alan Hunt, Walter F Stowy, Emma Moore, Amanda Ursell, Lesley White, John Jay, Dr Charles, Susan d'Arcy, Max Glaskin, Frank Whitford, Roy Porter, John Stansell, Ivo Tennant, Addison de Witt, Sally Payne, J A Cowell, Michael Fake, Kirstie Hamilton City Editor, Edin Hamzic, Jeremy Utton, Nick Pitt, Penny Wark, Juliette McAuliffe, Sebastian Hamilton, Andrew Sullivan, Neil Wormald, Edward Welsh, Mary Wilson, Aoife O'Brien, Richard Eaton, Stephen Grey Home Affairs Correspondent, Joseph Dunn, Tony Allen-Mills, Martin James, Christina Waugh, Robert Sandall, Alison James, Irwin Stelzer, Sian Phillips, Jane Haworth, Stephen Hayward, David Dougill, Pat Rowley, Henry McDonald, Wendy Leigh, Stuart Barnes, David Hewson, Harvey Porlock, Yvonne Ridley, Rosalind Livingston, Margaret Coles, Hugh Canning, Peter Watson, Jeremy Clarkson, Peter Kemp, S Jeffries, Peter Conradi, Alan Brownjohn, Louise Taylor, Jennifer Miller, Edward Porter, Stewart Lee, Peter Durisch, Michael Jones, Joan Smith, George Perry, Graham Otway, Robin Marlar, Charlotte Atkins, Nick Gardner, Shelley von Strunckel, Geoffrey Wheatcroft, Peter Warren, Paul Nuki Consumer Affairs Correspondent, Rob Steen, Geoffrey Dicks, Mike Laws, Paul Ham, Stuart Wavell, Jack Millan, Jonathan Leake Transport Correspondent, Sue Lawrence, Michael Heseltine, Jonathan Berman, Jeff Randall, Bernadette Cole, David Mullin, Smita Talati, Eleanor Bailey, Anna Mandell, Olga Craig, Paul Driver, Simon Fanshawe, Ann McFerran, Nicholas Hellen, Caroline Scott, Ian Hawkey, Ian Chadband, Jerome Burne, Libby Eves, Richard Girling, Michael Prescott Chief Political Correspondent, Kirstie Hamilton, Mark Edwards, Tom Shone, Rufus Olins, David Lawrenson, Camilla Cheyney, Nick Peters, Raymond Keene, John Karter, Gareth Huw Davies, Marina Cantacuzino, Bonnie Estridge, Andrew Roberts, Marie Colvin, Simon Willis, Debbie Hill, Diana Wright, Kipper Williams, Alistair McConnachie, Cosmo Landesman, Frank Kane, Stephen Jones, S T, Richard Evans, Michael Wright, Maurice Saatchi, Jane Preddy, Adrienne Connors, Andrew Smith, Robert Elms, Steve Connor Science Correspondent, Martin Searby, Keith Wheatley, Claire Oldfield, F G, Thomas Shone, Zoë Linkson, Mrs F E, Rasselas, Cheryl Holmes Perfect, Bryan Appleyard, Lois Rogers Medical Correspondent, Stephen McGinty, Stephen Armstrong, Lesley Eames, Christopher Goodwin, Austin Hyland, Josh Salzmann, Mark Prigg, Victoria O'brien, Roland White, David Windle, Garth Alexander, Dr Richard Fisher, Peter Johnson, Rachel Cooke, Mrs C S, William Rees-Mogg, Janet Street-Porter, Alexandra Stevens, Alex Fortune, Andrew Mueller, Brian Marber, Jack Hall, Judith O'Reilly, Mark Franchetti, Ray Hutton, Jonathan Powell, Angela Linforth, Rufus Olins Deputy City Editor, Peter Watts, Kevin McCarra, Peter Savill, Matthew Parris, Louisa Young, Frank McLynn, Michael Sheridan, Sean Hargrave, David Starkey, Simon Callow, Margaret Walters, Matthew Lynn, Godfrey Smith, Sarah Stacey, Simon Halberstam, Philip Ker, John Waples, Kirsty Milne, A A Gill, Andrew Malone, David Hutcheon, Rajeev Syal, Kirsty Lang, Nadine Meisner, Chrissy Iley, Lauren St John, Robert Johnston, Stephen Pettitt, Kevin Goldstein-Jackson, Cherry Norton, Andrew Lorenz, Naomi Caine, Liam Clarke, David Wickers, Claire Rayner, Hazel Courteney, Thomas Mann, Mr B Kerswill, M V, John Cornwell, Om Midha, Nicholas Hellen Media Correspondent, Steve Connor, Joe Lovejoy, Rupert Steiner, Alistair Sinclair, Simon Sebag Montefiore, Hugh Godwin, Mike Hammond, Simon Trump, Anthony Howard, Terry Dolan, Walter Ellis, Joanna Simon, India Knight, James Park, Mandy Piggot, Saffron Aldridge, Tom Bower, Dan Pearson, John Griffith, Boris Schapiro,
... how to turn brats into buddies Dominica: the cortisol test The agony and the ecstasy To be ...
1997 - Gale Group | Sunday Times HA GDA
Charles A. Nugent, William D. MacDiarmid, Ashley Nelson, Frank H. Tyler,
The rate of cortisol production during maximal stimulation with ACTH can be determined with radioisotopes, but a practical non-isotopic technique would be ... their results were influenced by the rate of cortisol disposal, the degree of protein binding and the volume of distribution of cortisol in addition to its rate of production. To ... problems, patients were studied won separate occasions with cortisol and ACTH infusions. The cortisol infusions were given at the rate normal subjects produced cortisol in response to maximal stimulation with ACTH. At ...
Tópico(s): Stress Responses and
1963 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Melvin M. Ketchel, Elaine Garabedian,
ABSTRACT The amount of cortisol-4- 14 C bound by human leucocytes in a non-protein balanced salt solution was found to have a linear relationship to the concentration of cortisol-4- 14 C for a given number of ... number of leucocytes for a given concentration of cortisol-4- 14 C. The binding was not affected ... blue, malonate, hydroxylamine or semicarbazide. The binding of cortisol-4- 14 C by leucocytes was found to ... temperature dependent. At 0° C, no binding of cortisol-4- 14 C was detected. From 10° to ...
Tópico(s): Stress Responses and
1963 - Oxford University Press | European Journal of Endocrinology
JAQUELINE A. GUIGNARD-DE MAEYER, John F. Crigler, Norman I. Gold,
Quantitative estimations of the urinary cortisol metabolites, ATHF, THF and THE, were obtained in 12 patients with Cushing's syndrome and surgically demonstrated bilateral adrenal hyperplasia. Ten ... indicating a significant alteration in the metabolism of cortisol. Two of the patients (both with active disease ... treated) showed normal proportions of these 3 urinary cortisol metabolites. Thus, 2 groups of patients with Cushing's syndrome are distinguished by differences in cortisol metabolism. Two of the patients excreting a low ...
Tópico(s): Hormonal Regulation and Hypertension
1963 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
W. R. Beisel, Vincent C. DiRaimondo, Peter H. Forsham,
... appears fundamental in regulating the availability of circulating cortisol*for physiologic activity in tissues, for inactivation by ... plasma protein components are involved in binding nonmetabolized cortisol (1-3). At physiologic concentrations, plasma cortisol is bound predominantly by an alpha globulin termed ... This protein has a high binding affinity for cortisol, but is present only in low concentrations and ... becomes rapidly saturated as the level of plasma cortisol is raised above normal. The other binding protein, ...
Tópico(s): Electrolyte and hormonal disorders
1964 - American College of Physicians | Annals of Internal Medicine
STANLEY S. DUNKELMAN, B. J. Fairhurst, John E. Plager, Christine Waterhouse,
Cortisol metabolism in obesity was studied in 11 grossly obese patients (96–150 kg) and in 8 control patients. Plasma time course disappearance studies of cortisol-1, 2-3H were done in the basal and ACTHstimulated states. A highly specific plasma cortisol determination was used. The results were also compared ... indicated by increased urinary 17-OHCS excretion, increased cortisol production rates and excessive increase in these values with ACTH. Some obese patients had normal cortisol pools and low plasma cortisol concentrations, others had ...
Tópico(s): Adrenal Hormones and Disorders
1964 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
SUMMARY The concentration of cortisol in peripheral plasma (μg./100 ml.) was 0·6 ± 0·1 ( s.e. ) in penned sheep accustomed to handling and ... level in man or the guinea-pig. Plasma cortisol in the goat (mean 1·2) and the ... 6 ± 0·3) was also low. Freely diffusible cortisol was distinguished from protein-bound hormone by gel ... capacity (μg./100 ml.) of sheep plasma for cortisol at room temp. (1·7 ± 0·2) was ... minimal estimates, since partial dissociation of the transcortin-cortisol complex occurred under the test conditions. Sheep plasma ...
Tópico(s): Genetic and phenotypic traits in livestock
1964 - Bioscientifica | Journal of Endocrinology
William R. Beisel, JUAN J. COS, Richard Horton, Ping Yu Chao, Peter H. Forsham,
The mechanisms leading to the renal excretion of cortisol have been studied over a wide range of plasma cortisol concentrations. In 3 normal adult males with endogenous plasma cortisol suppressed by dexamethasone, cortisol was infused intravenously in successively increasing amounts and simultaneous renal clearances of cortisol and inulin were determined after brief equilibration at each new concentration of plasma cortisol. In other subjects, clearances of endogenous cortisol and creatinine were measured. Urinary cortisol was quantitated ...
Tópico(s): Stress Responses and
1964 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
SUMMARY When labelled cortisol was injected intravenously into sheep it disappeared rapidly from blood. A few minutes after injection the specific activity of plasma cortisol decreased in a simple exponential manner, and it was therefore assumed that cortisol was contained in one pool. Cortisol pool sizes and turnover rates were calculated from plasma cortisol specific activity and its rate of change. The ... so calculated are higher than the rates of cortisol secretion reported by other workers. Because the turnover ...
Tópico(s): Effects of Environmental Stressors on Livestock
1964 - Bioscientifica | Journal of Endocrinology
F. H. Franken, Heiko Zimmermann,
ABSTRACT Few studies on the excretion of cortisol and cortisone in urine with simultaneous estimations of aldosterone have been performed in cases of Cushing's Syndrome. Using the methods of Neher & Wettstein (1956) for the determination of cortisol, cortisone and aldosterone, studies were made on 8 ... in 3 cases. The increase in excretion of cortisol was much greater than that of cortisone, while ... increased, was not very large. In 5 cases cortisol, cortisone, aldosterone and the 17-OHCS were determined ...
Tópico(s): Hormonal Regulation and Hypertension
1962 - Oxford University Press | European Journal of Endocrinology
A series of cortisol “secretion rates” was performed on a group of totally adrenalectomized patients maintained on cortisol (llβ,17α,21-trihydroxy-4-pregnene-3,20- ... rate was compared with the known quantity of cortisol administered during the period of study. It was ... collection contains the metabolites of 70 % of the cortisol secreted during the time of study and the metabolites of 30% of the cortisol secreted during the 24 hours before the urine ... basal conditions, this delay in the excretion of cortisol metabolites will not affect the accuracy of a ...
Tópico(s): Hormonal Regulation and Hypertension
1962 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
C. H. GRAY, John M Greenaway, N. J. Holness, D A Shaw,
SUMMARY The metabolism of [4- 14 C]cortisol in a patient with Cushing's syndrome has been studied by the isolation, identification and measurement of the specific radioactivities of the major metabolites. The results show that the metabolism of cortisol was not abnormal in the aspects studied. The biological half-lives of cortisol and of the tetrahydrocorticosteroid metabolites were found to ... of metabolites indicated that the metabolic pathways of cortisol were normal. There was no evidence for an ...
Tópico(s): Pituitary Gland Disorders and Treatments
1962 - Bioscientifica | Journal of Endocrinology
David J. Morris, Frederick W. Barnes,
... approach to eventual understanding of the role of cortisol in the liver can be made through separation of possible complexes formed by cortisol in the cell. 1. 1. Intraperitoneal and intravenous injections of [4-14C]cortisol (2 μC and 0.25 μC respectively) showed ... of experiments in which a pulse of [14C]cortisol was followed by a chase of unlabeled cortisol gave results which indicated two types of attachment ... In a series of intravenous injections of [14C]cortisol in male and female adrenalectomized rats, it was ...
Tópico(s): Diet and metabolism studies
1967 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - General Subjects
... the degree of binding by plasma proteins of cortisol by a technique of pressure ultrafiltration at 37° after addition of radioactively labelled cortisol. In normal subjects, the mean concentration of transcortin ... l./mole. Evidence of increased protein binding of cortisol was obtained in oestrogen-treated subjects and in ... latter subjects normal levels of non-protein bound cortisol were found. The mean level of non-protein bound cortisol in eight men treated with stilboestrol was increased, ... four of these subjects. The protein binding of cortisol in three patients with Cushing's syndrome and ...
Tópico(s): Stress Responses and
1967 - Bioscientifica | Journal of Endocrinology
Edward N. Ehrlich, Kathleen Lugibihl, C. Taylor, Mark Janulis,
In a prior study the rate of urinary cortisol excretion increased and aldosterone excretion decreased following the ... salt loads. In 2 of these subjects the cortisol secretion rates also rose. In the present study reciprocal relationship between cortisol and aldosterone excretion also prevails, aldosterone excretion rising and cortisol excretion declining in response to the diuretic action of hydrochlorothiazide and ethacrynic acid. The cortisol secretion rate was definitely decreased in 1 subject, ...
Tópico(s): Sodium Intake and Health
1967 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
J. Y. F. Paterson, F. A. Harrison,
SUMMARY Tritium-labelled cortisol was infused intravenously for about 4 hr. into sheep with autotransplanted left adrenal glands. The specific activity of plasma cortisol became constant about 2 hr. after beginning the ... and in almost all experiments, the rate of cortisol secretion and the concentration of cortisol in plasma were constant during the remainder of the period of infusion. The rate of cortisol turnover was calculated as the ratio of the rate of infusion of labelled cortisol and the constant specific activity which was attained ...
Tópico(s): Agriculture, Soil, Plant Science
1967 - Bioscientifica | Journal of Endocrinology
Johanna Dwyer, L. Lazarus, J. B. Hickie,
... observations have indicated that relatively large doses of cortisol are necessary to treat acute episodes of asthma ... Studies on 10 patients indicate that the plasma cortisol response to the intravenous injection of cortisol is less than normal in steroid‐treated patients, ... treated patients does not occur until the plasma cortisol level is at least 100 µg. per 100 ml. Studies of cortisol metabolism in the case of these 10 patients demonstrate an increased rate of removal of cortisol. The metabolic clearance rate of cortisol is higher ...
Tópico(s): Hormonal Regulation and Hypertension
1967 - Royal Australasian College of Physicians | Australasian Annals of Medicine
K. J. Kripalani, Donald L. Sorby,
... of degradation of the 17-dihydroxyacetone function of cortisol has been measured in a phosphate buffer system, ... of prednisolone under similar conditions. The binding of cortisol and its degradation products to human serum albumin ... found to be bound more strongly than was cortisol, but did not appear to compete with cortisol for binding sites on the protein molecule. In ... of degradation of the 17-dihydroxyacetone function of cortisol has been measured in a phosphate buffer system, ... of prednisolone under similar conditions. The binding of cortisol and its degradation products to human serum albumin ...
Tópico(s): Stress Responses and
1967 - Elsevier BV | Journal of Pharmaceutical Sciences
Walter Heyns, Hugo Van Baelen, Pieter De Moor,
... distinguished and were applied to the study of cortisol binding in plasma. (1) Endogenous steroids were removed ... a rather large amount of adsorbent. (2) The cortisol-binding capacity of plasma transcortin was measured after incubation with a balanced amount of adsorbent and cortisol. (3) A relative index of cortisol-protein binding proportional to the ratio of bound to unbound cortisol, was determined by incubation of charcoal-treated plasma with a trace of [1,2-3H]cortisol and appropriate amounts of adsorbent. (4) From this ...
Tópico(s): Hormonal Regulation and Hypertension
1967 - Elsevier BV | Clinica Chimica Acta
Herschel L. Estep, D. L. Litchfield, JOANNA P. TAYLOR, Henry St. George Tucker,
Plasma disappearance rates of 4-14C-cortisol or unlabeled cortisol, or both, were measured in relatively healthy patients before and again during laparotomy. The biologic halftime of labeled cortisol during surgery was unchanged or decreased slightly from the control value. When pharmacologic amounts of unlabeled cortisol were injected along with the labeled steroid, their ... equal. During surgery the half-time of unlabeled cortisol was significantly prolonged although halftime of labeled cortisol ...
Tópico(s): Stress Responses and
1966 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
SUMMARY Measurements of urinary free cortisol were made in convalescent subjects and in patients with established Cushing's syndrome and the results compared with those in acutely ill patients, in pregnancy and in surgical patients. Cortisol was measured in urine after paper chromatography, each ... to the recovery of added internal standard (tritiated cortisol). In a number of cases, the diurnal rhythm of cortisol excretion was also examined and the results related ... of renal function. The mean 24 hr. urinary cortisol excretion in 13 convalescent subjects was 74μg. (range ...
Tópico(s): Stress Responses and
1966 - Bioscientifica | Journal of Endocrinology
K. Birchall, William G. O'Day, Abram B. Fajer, Shlomo Burstein,
The urinary excretion of unconjugated cortisol and 6β-hydroxycortisol has been studied in the New World monkey Cebus albifrons. The mean values of cortisol in male 3-year-old (2–3 kg) ... Silber reaction after chromatographic purifications (using tracer tritiated cortisol to correct for procedural loss) was 170 μg/ ... daily excretion of 6β-hydroxycortisol (using the mean cortisol recovery to correct for procedural loss) was 100 ... a five-fold increase in the excretion of cortisol and 6β-hydroxycortisol, respectively, over control levels. Stress ...
Tópico(s): Adipose Tissue and Metabolism
1966 - Elsevier BV | General and Comparative Endocrinology
Edward N. Ehrlich, Kathleen Lugibihl, MAXINE L. LAVES, Mark Janulis,
... intake resulted in an increased rate of urinary cortisol excretion in each of 6 subjects. There were rises in the cortisol secretion rates measured in 2 of the subjects, ... were proportionately less than the corresponding increases in cortisol excretion. Although these results seemingly conflict with earlier reports that cortisol production is unresponsive to changes in salt balance, ... response was virtually the reciprocal of that of cortisol. Urinary corticosterone, pregnanediol and pregnanetriol were also measured ...
Tópico(s): Adrenal Hormones and Disorders
1966 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Edwin M. Bradley, Christine Waterhouse,
Analyses of arterial-blood radioactive-cortisol disappearance curves in human subjects by means of 2-compartment mathematical models have provided data on extravascular and intravascular cortisol. The intravascular cortisol pool is 460 ± 209 SD μg distributed in a volume equal to plasma volume. Extravascular cortisol is 2 or 3 times as largely distributed ... Estrogen treatment causes a marked increase in intravascular cortisol without significant effect on extravascular cortisol. This is in contrast to ACTH stimulation, which ...
Tópico(s): Stress Responses and
1966 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
The in vitro effect of cortisol on the cellular accumulation of free amino acid or a-aminoisobutyric acid and the incorporation of amino acid into protein was ... mouse ear strip preparation. It was determined that cortisol strongly inhibited amino acid incorporation into protein in ... inhibit it at all in succinate medium. The cortisol inhibition of the metabolism of these substrates to ... e., glucose, pyruvate and no inhibition of succinate. Cortisol usually shows at least a 3-hr latent ... 30 min by preincubation of the tissue with cortisol in succinate medium. These data are interpreted to ...
Tópico(s): Coenzyme Q10 studies and effects
1970 - Oxford University Press | Endocrinology
Ralph E. Chapman, J. M. Bassett,
SUMMARY The effects of prolonged administration of cortisol on epithelial and dermal tissues were examined in three groups of non-pregnant ewes with different food intakes. The changes observed depended on the degree of increase in plasma cortisol and in some instances on the amount of food eaten. Successive increases in plasma cortisol up to about 3 μg/100 ml progressively ... In the latter, a slight increase in plasma cortisol to about 1 μg/100 ml stimulated wool ... epithelial and dermal components was maximal when plasma cortisol remained above about 3 μg/100 ml. Follicle ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
1970 - Bioscientifica | Journal of Endocrinology