Jiazhang Qiu, J. Wang, Huidan Luo, Xiaonan Du, Hui Li, Mingjing Luo, Jingshi Dong, Z. Chen, Xuming Deng,
To determine the antimicrobial activity of costus (Saussurea lappa) oil against Staphylococcus aureus, and to evaluate the influence of subinhibitory concentrations of costus oil on virulence-related exoprotein production in staph. ... a broth microdilution method, and the MICs of costus oil against 32 Staph. aureus strains ranged from ... to evaluate the effects of subinhibitory concentrations of costus oil on virulence-associated exoprotein production in Staph. aureus. The data presented here show that costus oil dose dependently decreased the production of α- ...
Tópico(s): Probiotics and Fermented Foods
2010 - Oxford University Press | Journal of Applied Microbiology
Madan Mohan Pandey, Subha Rastogi, Ajay Kumar Singh Rawat,
Saussurea costus (Falc.) Lipchitz syn S. lappa C. B. Clarke (commonly known as 'Kuth') belonging to the family Asteraceae ... In different folk medicines the roots of S. costus are used to treat various disorders like ulcer, ... developed for proper identification of roots of S. costus and its differenciation from A. lappa as well ... detailed morphoanatomical studies revealed that roots of S. costus can be distinguished from A. lappa on the ... schizogenous resin ducts observed in roots of S. costus, were absent in A. lappa.. Besides, the HPTLC ...
Tópico(s): Phytochemistry and Biological Activities
2007 - Korean Society of Pharmacognosy | Natural Product Sciences
Xiaohong Wang, Li Dan, Yong Zhang, Shuang Wu, Fang Tang,
... disease that occurs in the colon and rectum. Costus root is a type of traditional Chinese medicine ... of gut bacteria. However, the molecular mechanisms underlying Costus root-mediated improvements in ulcerative colitis remain unclear. A complex formula of Costus root granules was created and investigated in the ... as a control. The potential mechanism mediated by Costus root granules was also analyzed in colonic epithelial ... The results of the present study demonstrated that Costus root granule treatment inhibited inflammation in colonic tissue. ...
Tópico(s): Cancer Cells and Metastasis
2018 - Spandidos Publishing | Experimental and Therapeutic Medicine
Rohit Kumar Nadda, Aaliya Ali, Renu Chib Goyal, P. K. Khosla, Rohit Goyal,
Aucklandia costus Falc. a medicinal plant is native to the Himalayan region and synonymous with Saussurea costus, Saussurea lappa, and Aucklandia lappa. It has an ... to Ayurveda, Unani, Siddha, and Traditional Chinese Medicine, Costus roots are recommended for leukoderma, liver, kidney, blood ... ethnopharmacological uses and scientific studies conducted on A. costus with chemical constituents, safety & toxicity data including future ... journals, websites, and books mentioned the use of costus roots in local and traditional practices. CITES included ...
Tópico(s): Natural product bioactivities and synthesis
2020 - Elsevier BV | Journal of Ethnopharmacology
Sofi Imtiyaz Ali, V. Venkatesalu,
Saussurea costus (Falc.) Lipsch. Syn. Saussurea lappa C.B. Clarke belongs to family Asteraceae and is a critically endangered ... a therapeutic herb of North - West Himalaya. Saussurea costus has been traditionally used to treat a variety ... collect the widespread review of literature on Saussurea costus. The scientific names were authenticated by using Kew ... have been identified as major phytoconstituents of Saussurea costus with great potency to develop as a drug ... pharmacological experiments convincingly confirmed the potential of Saussurea costus with anticancer, anti-ulcer, hepatoprotective activities, etc. providing ...
Tópico(s): Plant Toxicity and Pharmacological Properties
2021 - Elsevier BV | Phytochemistry Letters
Gireesh Gangadharan, Santhosh K. Thomas, Binoy Joseph, C.S. Paulose,
The leaves of Costus pictus D. Don were used extensively for its antihyperglycemic activity by the people in Kerala, India. In the present ... insulin secretory activity of an aqueous extract of Costus pictus leaf extract was investigated in streptozotocin induced ... was done to determine the effective dose of Costus pictus extract. Aqueous extract of Costus pictus leaves was given orally to the diabetic ... The oral administration of an aqueous extract of Costus pictus at a dose of 250 mg/kg ... at the end of 14 days treatment. The Costus pictus leaf extract significantly increased glucose induced insulin ...
Tópico(s): Pancreatic function and diabetes
2009 - Elsevier BV | Journal of Ethnopharmacology
Pramod Chandra, Joel T. Heinen, B. S. Negi, Jagdish C. Kaim,
Saussurea costus (Falc.) Lipsch., (Asteraceae) known in English as Costus, is a threatened Himalayan medicinal plant listed on CITES ( ... on the IUCN Red List. Wild collection of Costus is banned in India and permission is required ... District, Uttarakhand, India to determine the status of Costus cultivation, problems associated with its marketing and the ... nine farmers in the study area were cultivating costus and interest in its cultivation had increased in ... farmers within the study area. The area under Costus cultivation per farm was fairly constant (0.5 ...
Tópico(s): Indian History and Philosophy
2019 - Wildlife Information Liaison Development Society | Journal of Threatened Taxa
Ebtisam A. Marzook, Ahmed Samy El-Bayoumy, F. A. Marzook,
Carnosine is an antioxidant dipeptide and Costus speciosus is an Indian herb with powerful antioxidant activity. Study the possibility of using Costus and carnosine to treat hemolysis concerns induced oxidative ... fourth groups were injection with the extract of Costus speciosus and carnosine, respectively. At the end of ... LDH, G6PD, direct and indirect bilirubin were estimated. Costus significantly protects all hematological parameters such as hemoglobin, ... radiation due to its powerful antioxidant effects. Also Costus retained LDH, G6PD, and bilirubin levels to normal ...
Tópico(s): Medicinal Plants and Bioactive Compounds
2019 - Elsevier BV | Journal of Radiation Research and Applied Sciences
Shalika Rathore, Pritam Debnath, Rakesh Kumar,
... belongs to the flowering plant family Asteraceae. Saussurea costus (Falc.) Lipsch. commonly-known as kuth or costus, an imperative herb endemic to the Himalayan region ... for pharmaceutical industries. The principal components of S. costus are costunolide, dehydrocostus lactone, and cynaropicrin. Costus has been traditionally used in herbal medications with ... escalating demand, unscientific collection, and vicious harvesting of costus causing elimination and dwindling the plant status in ... suitable drug formulation source. The available reviews on costus are relatively restricted to a scope or obsolete. ...
Tópico(s): Sesquiterpenes and Asteraceae Studies
2020 - Elsevier BV | Journal of Applied Research on Medicinal and Aromatic Plants
Dohyun Choi, Jiyeon Kim, Jinho An, Seung-Hyun Sung, Hyunseok Kong,
Saussurea costus (synonym: Aucklandia lappa Decne) is a medicinal plant distributed in Yunnan, Guangxi, and Sichuan in China. In ... this was to prove the efficacy of S. costus by analyzing its effect on the biological mechanisms ... induce BPH, and were later administered with S. costus (20, 40 mg/kg). After 12 weeks, histological ... to confirm the anti-inflammatory efficacy of S. costus.In the serum and tissue of S. costus-treated BPH rats, a significant reduction in prostate ... index, and hormone regulation factors was observed. S. costus also increased the levels of apoptosis marker proteins ...
Tópico(s): Hormonal and reproductive studies
2021 - Elsevier BV | Journal of Ethnopharmacology
Engy Mohsen, Ali H. El‐Far, Kavitha Godugu, Fatma Elsayed, Shaker A. Mousa, Inas Y. Younis,
Saussurea costus Falc with synonymous Aucklandia costus, S. lappa, and A. lappa, is an ancient perennial plant native to Himalayan region. S. costus possesses an ethnopharmacological background for treating diarrhea, tenesmus, ... study, we investigated the phytochemical constituents of S. costus and its anticancer potential against human colon (HCT116) ... Sitosterol were identified for the first time in costus oil. Therefore, in the current study, S. costus extract induced apoptotic and anti-angiogenic effects against ...
Tópico(s): Phytochemistry and Biological Activities
2021 - Elsevier BV | Phytomedicine Plus
Brilliance Onyinyechi Anyanwu, Anthonet N. Ezejiofor, Ify L. Nwaogazie, Onyewuchi Akaranta, Orish Ebere Orisakwe,
The study evaluated the protective effect of Costus afer on low-dose heavy metal mixture (LDHMM)-mediated effects in the testis of albino rats. The weight-matched animals were divided into ... of (PbCl2 + CdCl2 + HgCl2), combination of metal mixture + Costus afer at 750 mg/kg, combination of metal mixture + Costus afer at 1,500 mg/kg, combination of metal mixture + Costus afer at 2,250 mg/kg and combination ... changes in the testis. Treatment of rats with Costus afer (750, 1,500 and 2,250 mg/ ... p < .05) the LDHMM-mediated toxicity. Treatment with Costus afer also reversed the testicular weight and LDHMM ...
Tópico(s): Mercury impact and mitigation studies
2020 - Wiley | Andrologia
Amy C. Keller, Ina Vandebroek, Youping Liu, Michael J. Balick, Fredi Kronenberg, Edward J. Kennelly, Anne-Marie B. Brillantes,
Costus spicatus Sw. (Costaceae) is a prominent medicinal herb used by Dominicans in the Dominican Republic and ... plant to treat hyperglycemia. Insulina was identified as Costus spicatus. We tested the ability of a tea made from the leaves of Costus spicatus to alter glucose homeostasis in C57BLKS/J ( ... 6/5) were given ad lib access to Costus spicatus tea or water, respectively. Weight gain and ... after the 10-week study period showed that Costus spicatus tea consumption did not alter insulin sensitivity. ...
Tópico(s): Consumer Attitudes and Food Labeling
2008 - Elsevier BV | Journal of Ethnopharmacology
HarishChandra Andola, Hema Lohani, Nirpendra Chauhan, Garima Gwari, Ujjwal Bhandari,
Saussurea costus (Falc.) Lipschitz, syn Saussurea lappa C.B. Clarke, one of the best-known species within this genus, is commonly known as costus. Due to the remarkable biological activity of S. costus and its constituents it will have an appropriate ... is to study the volatile constituents of S costus cultivated in Uttarakhand Himalayas.The volatile constituents were isolated from the root of S costus cultivated in Chamoli district of Uttrarakhand by hydro ... to be completely absent in our samples.S. costus volatile oil constituents are superior in terms of ...
Tópico(s): Natural product bioactivities and synthesis
2013 - Medknow | Pharmacognosy Research
... assessing the protective effect of the medicinal plant Costus speciosus against genotoxicity and histopathological alterations of streptozotocin ( ... STZ injection); 3) STZ + 50 mg/kg bw costus (oral administration); 4) STZ + 100 mg/kg bw costus; 5) STZ + 150 mg/kg bw costus; 6) STZ + 50 mg/kg bw nanocostus (oral ... DNA damage, chromosomal aberrations and histopathological changes. However, costus or nanocostus treatment reduced all these parameters especially ... these results strongly suggest that the extract of Costus speciosus might be anti-genotoxic, and anti-histopathologic ...
Tópico(s): Food Science and Nutritional Studies
2015 - OMICS Publishing Group | Journal of Nutrition & Food Sciences
M. Ferosekhan, A R. Mahesh, Sambandam Ravikumar,
... attempt to find out the antidiabetic property of Costus species. Fresh elder leaves of species viz., Costus pictus and Costus speciosus were collected from Western Ghats, Tamil Nadu. ... α-amylase inhibitory study, the maximum inhibition of Costus pictus was of 88.75% at a concentration ... ml-1. Glucose uptake inhibition assay data suggests Costus species is significant in inhibiting glucose diffusion. It is concluded from the present study that the Costus species extracts potentiate the antidiabetic activity and can ...
Tópico(s): Diet, Metabolism, and Disease
2016 - | International Journal of Current Research in Biosciences and Plant Biology
Chandra Prakash Kala, Syed Salman Ali, Sudhir Chaudhary,
Objective: Costus speciosus Koen. (Ginger) is an Indian ornamental plant, belonging to family Costaceae. The present research work deals ... of standardization parameter regarding comparative pharmacognostic study between Costus speciosus and Zingiber officinale rhizome.Methods: Macroscopic and ... as an absence of odor and taste in Costus speciosus and presence of pungent and aromatic odor ... found whereas the absence of the same in Costus speciosus rhizome was found in the microscopic evaluation. ... differences. The presence of saponin, carbohydrate, glycosides in Costus speciosus whereas Zingiber officinale revealed the presence of ...
Tópico(s): Essential Oils and Antimicrobial Activity
2016 - | International Journal of Current Pharmaceutical Research
Ugochi Olivia Njoku, O. F. C. Nwodo, Martins Obinna Ogugofor,
<em>Costus afer</em> leaf extract is one of the native heritages of folklore medicine in Nigeria, used for ... cardioprotective potential of the methanol extract of <em>Costus afer</em> leaves on CCl<sub>4</sub>- ... aspirin and CCl<sub>4</sub>) and <em>Costus afer</em> extract treated (extract and CCl<sub>4</sub>) groups. <em>Costus afer</em> extract was administered in four doses; ... also observed when compared to normal control. <em>Costus afer</em> leaf extract protected against CCl< ...
Tópico(s): Phytochemicals and Antioxidant Activities
2017 - | Asian Journal of Pharmaceutical Research and Health Care
Emad M. Abdallah, Kamal A. Qureshi, Ahmed M. H. Ali, Gamal Osman Elhassan,
... aimed to evaluate some biological activities of Saussurea costus (S. costus) such as phytochemical constituents, antimicrobial activity and antifeedant ... that the methanol extract of roots of S. costus are rich in some bioactive phytochemical compounds such ... with the methanol and ethanol extracts of S. costus, namely Bacillus cereus ATCC 10876 (IZ 16.0± ... no effect.Furthermore, the ethanolic extract of S. costus provided an anitfeedant effect toward Spodoptera littoralis larvae ... fi ndings provide evidence that roots of Saussurea costus is rich in bioactive phytochemical compounds and it ...
Tópico(s): Essential Oils and Antimicrobial Activity
2017 - | Bioscience Biotechnology Research Communications
Samy E. Elshaer, Gamal M. Hamad, E. S. E. Hafez, Hoda H. Baghdadi, Fatma M. El‐Demerdash, Jesús Simal‐Gándara,
... the effects of three different extracts of Saussurea costus roots (ethanol, methanol, and water) as a food ... 75 mg/kg BW, single oral dose), S. costus 70% ethanol, 70% methanol, and aqueous extracts (300 ... showed that the 70% ethanol extract of S. costus has a higher concentration of total phenolic content, ... methanol and water extracts. Rats pretreated with S. costus extracts reduced the harmful effects induced by NaNO2 ... as compared to the NaNO2 group. Furthermore, S. costus improved the histopathological alterations in the liver and ...
Tópico(s): Phytochemicals and Antioxidant Activities
2022 - Elsevier BV | Food and Chemical Toxicology
... ant assemblages at the extrafloral nectaries of four Costus spp. (Zingiberaceae) in Panama were quantified to determine ( ... factors that influence ant assemblages. Although inflorescences of Costus spp. commonly produce extrafloral nectar for several months ( ... species expected from equal sampling (40 inflorescences per Costus sp.) was 9 for C. pulverulentus, 13 for ... N = 41—80) did not plateau for any Costus sp., indicating that a large number of ant ... richness and the similarity in nectar characteristics among Costus spp. suggest these are relatively generalized mutualisms with ...
Tópico(s): Insect and Pesticide Research
1982 - Wiley | Ecology
Kenneth J. Sytsma, Richard W. Pippen,
An intersectional hybridization event between hummingbird-pollinated Costus pul- verulentus (sect. Ornithophilus) and large bee-pollinated C. guanaiensis var. macrostrobilus (sect. Costus) in Belize, Central America, is documented by analyses of ... arose by breakdown of strict hummingbird pollination in Costus pulverulentus. Costus L. (Costaceae) occurs in moist habitats in the ... spi- rally arranged phyllotaxy and showy terminal inflorescence. Costus is often found associated with species of Calathea, ...
Tópico(s): Botanical Research and Applications
1985 - American Society of Plant Taxonomists | Systematic Botany
AkhilaJ Shetty, D C R Choudhury, Rejeesh, Vinod S. Nair, Maria Kuruvilla, Shashidhar Kotian,
Costus igneus, commonly known as insulin plant in India, belongs to the family Costaceae. Consumption of the ... to evaluate the effect of the leaves of Costus igeus on dexamethasone-induced hyperglycemia in male Wistar ... 500 mg/kg/day of powdered leaves of Costus igeus in distilled water orally or Glibenclamide 500 ... 250 and 500 mg/kg powdered leaf of Costus igeus and Glibenclamide 500 microg/kg decreased the ... induced hyperglycemia (P < 0.01). The leaves of Costus igeus reduced the fasting and postprandial blood sugar ...
Tópico(s): Pharmacology and Obesity Treatment
2010 - Medknow | International Journal of Ayurveda Research
Vishnu Bhat, A. Nirmalesh Naveen, Kamat Akshay, Mukesh S. Sikarwar, M. B. Patil,
... this research was to investigate antidiabetic activity of Costus igneus (also known as insulin plant) leaves extracts ... A comparison was made between the action of Costus igneus extract and a known antidiabetic drug glibenclamide ( ... performed in experimental diabetic rats. Ethanolic extracts of Costus igneus were obtained by simple maceration method & were ... mg/kg body weight) as per OECD guidelines. Costus igneus ethanolic extract showed significant (P<0.001) ... diabetic rats. We are the first to report Costus igneus leaves pharmacognostic, phytochemical investigations and its antidiabetic ...
Tópico(s): Mangiferin and Mango Extracts
2010 - Elsevier BV | Journal of Pharmacy Research
Sanni Momoh, O. W. Yusuf, M. Adamu, Charles O.C Agwu, Francis O. Atanu,
... diabetic potentials. In the present study we screened Costus afer for the presence of plant products and ... 800mg/kg) of the methanolic leaf extract of Costus afer, standard hypoglycaemic drug glibenclamide or a combination ... of alkaloids, flavanoids, tannins, phenols, glycosides and terpenoids. Costus afer showed significant hypoglycaemic effect (p<0.05) ... unloaded rats. The results validate the use of Costus afer as a hypoglycaemic plant in native medicine. ... effects could be attributed to its phytochemical constituents. Costus afer could be a promising plant for the ...
Tópico(s): Ethnobotanical and Medicinal Plants Studies
2011 - Sciencedomain International | British Journal of Pharmaceutical Research
Anthoneth Ndidi Ezejiofor, Chinna N. Orish, Orish Ebere Orisakwe,
... in the management of diabetes mellitus, of which Costus afer is one. This study was designed to ... comparative ameliorating effects, of an aqueous extract of Costus afer Ker Gawl. (Costaceae) leaf and glibenclamide (GBM), ... renal tubules, and pancreatic cells after treatment with Costus afer. The glucose level was reduced significantly in the Costus afer treated diabetic rats compared with the non-treated diabetic group. Costus afer leaves seem to be effective against diabetic ...
Tópico(s): Phytochemical and Pharmacological Studies
2014 - Elsevier BV | Chinese Journal of Natural Medicines
G. Devendran, Ganesan Sivamani,
The bioactive components of Costus spicatus leaves have been evaluated using GC/MS. The chemical compositions of the ethanolic extract of Costus spicatus leaves were investigated using Perkin-Elmer Gas ... library. GC/MS analysis of ethanolic extract of Costus spicatus leaves revealed the existence of 1,2- ... each compound was discussed in this paper. As Costus spicatus can grow and spread easily and because ... and cheaper drug for various diseases. Key words: Costus spicatus , GCMS analysis, Bioactive components.
Tópico(s): Plant-Derived Bioactive Compounds
2015 - Society of Pharmaceutical Tecnocrats | Journal of Drug Delivery and Therapeutics
Ehab Tousson, Afaf El‐Atrsh, Merfaat Mansour, Abdallah Assem,
... plants are sources of novel drug discovery targets. Costus (Saussurea lappa) has been used as traditional Chinese ... conducted to examine the possible modifying effects of costus (S. lappa) root aqueous extract against kidney toxicity ... were divided into five groups (first, control; second, costus; third, ethephon; fourth, posttreated ethephon with costus; fifth, ethephon self-healing). There is a significant ... compared to the control group. As a result, costus root extract significantly reduced rat kidney toxicity after ...
Tópico(s): Pesticide Exposure and Toxicity
2019 - Wiley | Environmental Toxicology
Anthonet N. Ezejiofor, Orish Ebere Orisakwe,
... and an oxidative-stress inducer.The effect of Costus afer on metal-induced male reprotoxicity has not ... The present study investigates the protective effect of Costus afer aqueous leave extract on lead-induced reproductive ... were given 750, 1500 and 2250mg/kg of Costus afer orally, respectively while receiving Pb 2+ water ... compared to the control. Conclusion:The treatment with Costus afer exhibited dose-dependent significant changes in testicular ... changes induced by lead.Aqueous leaves extract of Costus afer may be protective against lead induced testicular ...
Tópico(s): Phytochemical and Pharmacological Studies
2019 - Brazilian Society of Assisted Reproduction | JBRA
Yousry Bolkiny, Ehab Tousson, Afaf El‐Atrsh, Mohamed A. Akela, Eman Farg,
... lipid pattern. In addition, the ameliorating role of Costus root extract supplementation was examined. Material and Methods: ... randomly divided into 5 groups; control, control with costus extract, hypo- and hyper-thyroids post-treated with costus root extract. Results: Present results revealed that, a ... mice compared to control. Treatments of mice with Costus root extract in both hypo- and hyperthyroidism modulates ... Our results could propose that the extract of Costus roots can be used as an adjuvant co- ...
Tópico(s): Thyroid Disorders and Treatments
2019 - Sciencedomain International | Annual Research & Review in Biology