Martine Arrio‐Dupont, Isabelle Cournil, P. Duie,
... Orsay, FranceSearch for more papers by this authorI. Cournil, I. Cournil Laboratoire d'Enzymologie Physico-chimique et momléculaire 91 ... Orsay, FranceSearch for more papers by this authorI. Cournil, I. Cournil Laboratoire d'Enzymologie Physico-chimique et momléculaire 91 ... M. Telegdi, Biokhimiya, 30, (1965), 148– 13 I. Cournil, Thèse de Spécialité, (1970), Orsay 14 C. Turano, ...
Tópico(s): Biochemical and Molecular Research
1970 - Wiley | FEBS Letters
Gaëlle Francine Tchouwa, Sabrina Eymard‐Duvernay, Amandine Cournil, Nadine Lamare, Laetitia Serrano, Christelle Butel, Silvia Bertagnolio, Eitel Mpoudi‐Ngolé, Elliot Raizes, Avelin F. Aghokeng, Sylvie Abia, Avelin F. Aghokeng, Silvia Bertagnolio, Dorothée Bessala, Christelle Butel, Corneluis Chebo, Oumarou Chifen, Amandine Cournil, John E Ebonloe, Sabrina Eymard‐Duvernay, Gaspary Fodjeu, Suzanne Izard, Brigitte Kamtie, Emmanuel Kiawi, Charles Kouam Kouam, Charles Kouanfack, Nadine Lamare, E. Mamang, Nadia Mandeng, Eyongetah Mbu, Bouba Mfokue, Jembia Mosoko, Bernard Nandjou, Mireille Mpoudi, Eitel Mpoudi‐Ngolé, Mariama Ndam, Anne Esther Njom Nlend, Batam Nlend, Cecile Nouboué, Pierrette Albertine Mbarga Omgba, Thierry Owono, Florant Oyono, Calixte Ida Penda, Elliot Raizes, Laetitia Serrano, Xavier Tchetnya, Christian Tchinou, Gaëlle Francine Tchouwa,
Pretreatment HIV drug resistance (PDR) has the potential to affect treatment outcome and mortality. We present here the first nationally representative PDR study conducted in Cameroon.
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2018 - Oxford University Press | Journal of Antimicrobial Chemotherapy
... is a clear heritable component in human longevity (Cournil & Kirkwood, 2001). In recent years large numbers of ... Aging 22: 265–272CrossrefCASPubMedWeb of Science®Google Scholar Cournil A, Kirkwood TB (2001) If you would live ...
Tópico(s): Spaceflight effects on biology
2005 - Springer Nature | EMBO Reports
Isabelle Cournil, Béatrice Casasnovas, Simone Helluy, Barbara S. Beltz,
... neuronal labeling in the juvenile lobster nervous system (Cournil et al. [1994] J. Comp. Neurol. 344 :455– ...
Tópico(s): Crustacean biology and ecology
1995 - Wiley | The Journal of Comparative Neurology
Alexandra Calmy, Tamara Tovar Sanchez, Charles Kouanfack, Mireille Mpoudi-Etame, Sandrine Leroy, Ségolène Perrineau, Martial Lantche Wandji, Darius Tetsa Tata, Pierette Omgba Bassega, Thérèse Abong Bwenda, Marie Varloteaux, Marcel Tongo, Eitel Mpoudi‐Ngolé, Alice Montoyo, Noémie Mercier, Vincent Le Moing, Martine Peeters, Jacques Reynes, Éric Delaporte, Alexandra Calmy, Tamara Tovar Sanchez, Charles Kouanfack, Mireille Mpoudi-Etame, Sandrine Leroy, Ségolène Perrineau, M Lantche-Wandji, D. Tetsa-Tata, P. Omgba-Bassega, T Abong-Bwenda, Marie Varloteaux, Marcel Tongo, Eitel Mpoudi‐Ngolé, Alice Montoyo, Noémie Mercier, Vincent Le Moing, Martine Peeters, Jacques Reynes, Éric Delaporte, Ahidjo Ayouba, A Agholeng, Christelle Butel, Amandine Cournil, Sabrina Eymard‐Duvernay, Bruno Granouillac, S.R. Izard, André Lacroix, Laetitia Serrano, Nicole Vidal, PJ Fouda, R Mougnoutou, J Olinga, V Omgba, SC Tchokonte-Ngandé, B Ymele, CD Epoupa-Mpacko, Marie‐Jeannette Fotso, R Moukoko, T Nké, A Akamba, S Lekelem, SB Tongo-Fotack, S Ngono, M. Tanga, E Ebong, G Edoul-Mbesse, Marcel Tongo, Laura Ciaffi, Sinata Koulla‐Shiro, Godfrey Manirakiza, E D Mimbé, Sylvie Boyer, Marwân‐al‐Qays Bousmah, Gwenaëlle Maradan, ML Nishimwe, Bruno Spire, MP Lê, Gilles Peytavin, Alpha Diallo, Isabelle Fournier, Claire Rekacewicz, Carmen Pérez Casas,
Updated WHO guidelines recommend a dolutegravir-based regimen as the preferred first-line treatment for HIV infection and low-dose efavirenz (400 mg) as an alternative. We aimed to report the non-inferior efficacy of dolutegravir compared with efavirenz 400 mg at week 96.We did a multicentre, randomised, open label, phase 3 trial in in three hospitals in Yaoundé, Cameroon, in HIV-1 infected antiretroviral-naive adults with an HIV RNA viral load of greater than 1000 copies per mL to compare dolutegravir ...
Tópico(s): HIV/AIDS Research and Interventions
2020 - Elsevier BV | The Lancet HIV
Pierre Chelle, Aurélie Montmartin, Pauline Damien, Michèle Piot, Michel Cournil, Anne Lienhart, Fabienne Genre‐Volot, Hérvè Chambost, Claire Morin, Brigitte Tardy,
The thrombin generation (TG) assay evaluates haemostatic balance, which is influenced by the levels of many coagulation factors and inhibitors. Our objective was to identify the determinant factors of TG in haemophilia A (HA) and haemophilia B (HB) patients and to compare them to those in healthy controls. Coagulation factor and inhibitor levels, and TG, were measured in platelet-poor plasma from 40 patients with HA, 32 patients with HB and 40 healthy subjects. Data were analysed using multiple regression ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2019 - Wiley | Haemophilia
Lee Fairlie, Catriona Waitt, Shahin Lockman, Michelle Moorhouse, Elaine J. Abrams, Polly Clayden, Marta Boffito, Saye Khoo, Helen Rees, Amandine Cournil, François Venter, Celicia Serenata, Matthew Chersich,
Abstract Introduction To adequately ascertain drug safety and efficacy, drug trials need to include participants from all groups likely to receive the medication following approval. Pregnant women, however, are mostly excluded from trials, and women participating are often required to use highly effective contraception and taken off study product (even off study) if they conceive. There is little commercial incentive for including pregnant women in clinical trials, even when preclinical animal and ...
Tópico(s): Reproductive System and Pregnancy
2019 - International AIDS Society | Journal of the International AIDS Society
Alice Atramont, V. Lindecker-Cournil, Jérémie Rudant, Ayden Tajahmady, Nicolas Drewniak, Annie Fouard, Mervyn Singer, Marc Léone, Matthieu Legrand,
Importance An aging population is increasing the need for intensive care unit (ICU) beds. The benefit of ICU admission for elderly patients remains a subject of debate; however, long-term outcomes across all adult age strata are unknown. Objective To describe short-term and long-term mortality (up to 3 years after discharge) across age strata in adult patients admitted to French ICUs. Design, Setting, and Participants Using data extracted from the French national health system database, this cohort study determined ...
Tópico(s): Palliative Care and End-of-Life Issues
2019 - American Medical Association | JAMA Network Open
Nongodo Firmin Kaboré, Armel Poda, Jacques Zoungrana, Ollo Da, Laura Ciaffi, Aoua Semdé, Issouf Yaméogo, Adrien Sawadogo, Éric Delaporte, Nicolas Méda, Sophie Limou, Amandine Cournil,
It has been reported that people living with HIV in West Africa exhibited the highest risks for chronic kidney disease (CKD) in the world. Here, we aimed at determining the CKD frequency and changes in kidney function during antiretroviral treatment (ART) in a large cohort of HIV-patients followed in Burkina Faso.We included ART-naive adults who initiated ART at the Day Care Unit of the Souro Sanou University Hospital between 01/01/2007 and 12/31/2016. We assessed the estimated glomerular filtration ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2019 - BioMed Central | BMC Nephrology
Gaëlle Francine Tchouwa, Sabrina Eymard‐Duvernay, Amandine Cournil, Nadine Lamare, Laetitia Serrano, Christelle Butel, Silvia Bertagnolio, Eitel Mpoudi‐Ngolé, Elliot Raizes, Avelin F. Aghokeng,
Population-based studies to estimate viral load (VL) suppression and rate of acquired HIV drug resistance (ADR) are essential in sub-Saharan Africa. We conducted the first nationally representative study estimating VL suppression and ADR in Cameroon.
Tópico(s): HIV Research and Treatment
2018 - Elsevier BV | EClinicalMedicine
Fabien Taieb, Yoann Madec, Amandine Cournil, Éric Delaporte,
Background UNAIDS recently defined the 90-90-90 target as a way to end the HIV epidemic. However, the proportion of virological success following antiretroviral therapy (ART) may not be as high as the anticipated 90%, and may in fact be highly heterogeneous. We aimed to describe the proportion of virological success in sub-Saharan Africa and to identify factors associated with the proportion of virological success. Methods We performed a systematic review and meta-analysis focusing on the proportion ...
Tópico(s): HIV/AIDS drug development and treatment
2017 - Public Library of Science | PLoS ONE
Michael R. Jordan, Martina Penazzato, Amandine Cournil, Adolfo Vúbil, Ilesh Jani, Gillian Hunt, Sergio Carmona, Gugu Maphalala, Nobuhle Mthethwa, Christine Watera, Pontiano Kaleebu, Christine Chakanyuka Musanhu, Sekesai Mtapuri‐Zinyowera, Janet Dzangare, Martine Peeters, Chunfu Yang, Neil Parkin, Silvia Bertagnolio,
Programs for the prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) have been scaled up in many low- and middle-income countries. However, HIV drug resistance (HIVDR) data among HIV-1–infected young children remain limited. Surveys of pretreatment HIVDR among children aged <18 months who were diagnosed with HIV through early infant diagnosis were conducted in 5 sub-Saharan African countries (Mozambique, Swaziland, South Africa, Uganda, and Zimbabwe) between 2011 ...
Tópico(s): HIV Research and Treatment
2017 - Oxford University Press | Clinical Infectious Diseases
Sabine Yerly, Alexandra Calmy,
... burden of drug resistance.12Jordan MR Penazzato M Cournil A et al.HIV drug resistance in African ...
Tópico(s): HIV Research and Treatment
2017 - Elsevier BV | The Lancet Infectious Diseases
Laura Ciaffi, Sinata Koulla‐Shiro, Adrien Sawadogo, Cheik Tidiane Ndour, Sabrina Eymard‐Duvernay, Pretty Rosereine Mbouyap, Liliane Ayangma, Jacques Zoungrana, Ndèye Fatou Ngom Gueye, Mohamadou Diallo, Suzanne Izard, Guillaume Bado, Coumba Touré Kane, Avelin F. Aghokeng, Martine Peeters, Pierre Marie Girard, Vincent Le Moing, Jacques Reynes, Éric Delaporte, Jacques Reynes, Éric Delaporte, Sinata Koulla‐Shiro, C.T. Ndour, Sawadogo Ab, M Seidy, Vincent Le Moing, Alexandra Calmy, Laura Ciaffi, NF Ngom Gueye, PM Girard, S Eholie, JB Guiard-Schmid, Marie‐Laure Chaix, Charles Kouanfack, Ioana Cristina Tita, Brigitte Bazin, Paula Garcia, Vincent Le Moing, S.R. Izard, Sabrina Eymard‐Duvernay, Laura Ciaffi, Martine Peeters, Laetitia Serrano, Amandine Cournil, Éric Delaporte, PR Mbouyap, R. Toby, N.M. Manga, Liliane Ayangma, M. Mpoudi, Ngole J Zoungrana, Mamadou Abdoulaye Diallo, NF Ngom Gueye, AF Aghokeng, Emilande Guichet, Olga Bell, Hortence Abessolo, MR Djoubgang, Godfrey Manirakiza, G Lamarre, T. Mbarga, S. Epanda, Angeline Bikié, T Nké, N. Massaha, E. Nke, D. Bikobo, J Olinga, O. Elat, A Diop, Babacar Diouf, N. Bara, MB Koita Fall, C. Touré Kane, FB Seck, Sophie Hill BA, P. Njantou, A. Ndyaye, Paulin Fao, René Traoré, Yves Sanou, Guillaume Bado, M Coulibaly, Eric Nagaonlé Somé, J. Some, A. Elisée Sié Kambou, A Tapsoba, Diamasso Sombié, S. Sanou, Boubacar Traoré, Philippe Flandre, Camille Michon, J. Drabo, François Simon,
Tópico(s): HIV Research and Treatment
2017 - Elsevier BV | The Lancet HIV
Robert Colebunders, Julia Irani, R.J. Post,
... 36Pion S.D. Kaiser C. Boutros-Toni F. Cournil A. Taylor M.M. Meredith S.E. et ...
Tópico(s): Immune responses and vaccinations
2016 - Elsevier BV | International Journal of Infectious Diseases
Produção Nacional
Revisado por pares
Mirela D’arc, Ahidjo Ayouba, Amandine Esteban, Gerald H. Learn, Vanina Boué, Florian Liégeois, Lucie Etienne, Nikki Tagg, Fabian H. Leendertz, Christophe Boesch, Nadège F. Madinda, Martha M. Robbins, Maryke Gray, Amandine Cournil, Marcel Ooms, Michael Letko, Viviana Simon, Paul M. Sharp, Beatrice H. Hahn, Éric Delaporte, Eitel Mpoudi Ngole, Martine Peeters,
Significance Understanding emerging disease origins is important to gauge future human infection risks. This is particularly true for the various forms of the AIDS virus, HIV-1, which were transmitted to humans on four independent occasions. Previous studies identified chimpanzees in southern Cameroon as the source of the pandemic M group, as well as the geographically more restricted N group. Here, we show that the remaining two groups also emerged in southern Cameroon but had their origins in ...
Tópico(s): Herpesvirus Infections and Treatments
2015 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Alain Makinson, Maurice Hayot, Sabrina Eymard‐Duvernay, Mylène Quesnoy, F. Raffi, L. Thirard, Fabrice Bonnet, Pierre Tattevin, Sophie Abgrall, Xavier Quantin, H. Léna, Sébastien Bommart, Jacques Reynes, Vincent Le Moing,
... this study possible: Suzanne Izard, Jonathan Lalet, Amandine Cournil and Bruno Granouillac (UMI 233, IRD, University Montpellier ...
Tópico(s): Pneumonia and Respiratory Infections
2014 - European Respiratory Society | European Respiratory Journal
Kirsten Simondon, Amandine Cournil, Jennifer S. Read, Marie‐Louise Newell, Cécile Cames, Nicolas Méda, Stanley Lüchters, Grace Mbatia, K. Naidu, Philippe Gaillard, Isabelle de Vincenzi,
Refraining from breastfeeding to prevent HIV transmission has been associated with increased morbidity and mortality in HIV-exposed African infants. The objective was to assess risks of common and serious infectious morbidity by feeding mode in HIV-exposed, uninfected infants ≤6 mo of age with special attention to the issue of reverse causality. HIV-infected pregnant women from 5 sites in Burkina Faso, Kenya, and South Africa were enrolled in the prevention of mother-to-child transmission Kesho Bora ...
Tópico(s): HIV/AIDS Research and Interventions
2014 - Elsevier BV | American Journal of Clinical Nutrition
Jacques Reynes, Amandine Cournil, Hélène Peyrière, Christina Psomas, E. Guiller, Marlène Chatron, Jean‐Paul Cristol, Stéphanie Badiou,
To assess the frequency of glomerular and tubular proteinuria in a cohort of HIV-infected patients, and to determine the factors associated with each type of injury.Cross-sectional study of 1210 consecutive HIV-infected adults followed in HIV outpatient unit (Montpellier/France).Spot urine protein to creatinine (uPCR), albumin to creatinine (uACR) and albumin to protein (uAPR) ratios were assessed. Glomerular injury was defined as uACR at least 30 mg/g or uPCR at least 200 mg/g with uAPR at least 0. ...
Tópico(s): HIV/AIDS Research and Interventions
2013 - Lippincott Williams & Wilkins | AIDS
Amandine Cournil, Sabrina Eymard‐Duvernay, Assane Diouf, Claire Moquet, J. Coutherut, Ndèye Fatou Ngom Gueye, Cécile Cames, Bernard Taverne, Kirsten Simondon, Papa Salif Sow, Éric Delaporte,
Background Bone status in HIV-infected patients on antiretroviral treatment (ART) is poorly documented in resource-limited settings. We compared bone mineral density between HIV-infected patients and control subjects from Dakar, Senegal. Methods A total of 207 (134 women and 73 men) HIV-infected patients from an observational cohort in Dakar (ANRS 1215) and 207 age- and sex-matched controls from the general population were enrolled. Bone mineral density was assessed by quantitative ultrasound (QUS) ...
Tópico(s): HIV Research and Treatment
2012 - Public Library of Science | PLoS ONE
Souleymane Doucouré, François Mouchet, Amandine Cournil, Gilbert Le Goff, Sylvie Cornélie, Yelin Roca, Mabel Guerra Giraldez, Z. Barja Simon, Roxana Loayza, Dorothée Missé, Jorge Vargas Flores, Annie Walter, Christophe Rogier, Jean Pierre Hervé, Franck Remoué,
Aedes mosquitoes are important vectors of re-emerging diseases in developing countries, and increasing exposure to Aedes in the developed world is currently a source of concern. Given the limitations of current entomologic methods, there is a need for a new effective way for evaluating Aedes exposure. Our objective was to evaluate specific antibody responses to Aedes aegypti saliva as a biomarker for vector exposure in a dengue-endemic urban area. IgG responses to saliva were strong in young children ...
Tópico(s): Vector-borne infectious diseases
2012 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Amandine Cournil, Isabelle de Vincenzi, Philippe Gaillard, Cécile Cames, Paulin Fao, Stanley Lüchters, Nigel Rollins, Marie‐Louise Newell, Kirsten Simondon, Jennifer S. Read,
To assess the relationship between infant feeding practices and mortality by 18 months of age among children born to HIV-infected mothers in the Kesho Bora trial (Burkina-Faso, Kenya and South Africa).Enrolled HIV-infected women were counseled to choose between breastfeeding up to 6 months or replacement feeding from delivery. Multivariable Cox models were used to compare the infant mortality risks according to feeding practices over time defined as never breastfed, weaned or still breastfed. The ...
Tópico(s): Global Maternal and Child Health
2012 - Lippincott Williams & Wilkins | AIDS
Assane Diouf, Amandine Cournil, K. Bâ-Fall, Ndèye Fatou Ngom-Guèye, Sabrina Eymard‐Duvernay, Ibrahima Ndiaye, Gilbert Batista, Papa Mandoumbé Guèye, P.S. Ba, Bernard Taverne, Éric Delaporte, Papa Salif Sow,
Cardiovascular risk factors in people on antiretroviral treatment (ART) are poorly documented in resource-constrained settings. A cross-sectional study was conducted in 2009 to assess prevalence of diabetes and hypertension in a sample of 242 HIV-infected patients who had initiated ART between 1998 and 2002 in Dakar, Senegal (ANRS 1215 observational cohort). World Health Organization (WHO) criteria were applied to diagnose diabetes and hypertension. Multiple logistic regressions were used to identify ...
Tópico(s): HIV/AIDS drug development and treatment
2012 - Hindawi Publishing Corporation | ISRN AIDS
Kirsten Simondon, Cécile Cames, Sabah Barigou, Amandine Cournil, Aldiouma Diallo,
Several studies have shown an association between an infant and young child feeding index (ICFI) and height-for-age Z-score (HAZ) in Latin America and Africa. A previous study was unable to reproduce these findings in 500 rural Senegalese 12–42-mo-old children. The relationship of ICFI, dietary diversity index (DDI), food variety index (FVI), meal frequency index (MFI), and breastfeeding (BF) to HAZ and growth in height/length over 6 mo was studied in 1060 6–36-mo-old Senegalese children during 2 visits. ...
Tópico(s): Child Nutrition and Feeding Issues
2012 - Elsevier BV | Journal of Nutrition
Amandine Cournil, Jean‐Marie Robine, Heiner Maier, Jutta Gampe, James W. Vaupel,
The International Database on Longevity contains exhaustive information on validated cases of supercentenarians that allows unbiased estimates of mortality after age 110. This chapter describes the structure and contents of the database, including the different categories of age-validation procedures.
Tópico(s): Insurance, Mortality, Demography, Risk Management
2010 - Springer Nature | Demographic research monographs
Amadou Garba, Sébastien D. S. Pion, Amandine Cournil, Jacqueline Milet, Dominique Schneider, G Campagne, Jean‐Philippe Chippaux, Denis Boulanger,
A better control of major neglected tropical diseases such as schistosomiasis is urgently needed to reduce their impact on public health in developing countries. To optimize the efficiency of intervention campaigns, we assessed the influence of individual human factors on the level of Schistosoma haematobium infection and morbidity in a typical Sahelian country (Niger). Random samples of 246 and 257 individuals were selected from general census in two villages with distinct patterns of schistosome ...
Tópico(s): Parasite Biology and Host Interactions
2010 - Elsevier BV | Acta Tropica
Produção Nacional
Revisado por pares
F. Barbieri, Amandine Cournil, Jorge Eduardo de Souza Sarkis, Eric Bénéfice, Jacques Gardon,
Tópico(s): Environmental Justice and Health Disparities
2010 - Springer Science+Business Media | Biological Trace Element Research
S. Mercier, Ndèye Fatou Ngom Gueye, Amandine Cournil, Annick Fontbonne, Nane Copin, Ibrahima Ndiaye, Anne‐Marie Dupuy, Cécile Cames, Papa Salif Sow, Ibra Ndoye, Éric Delaporte, Kirsten Simondon,
Objective: To assess adverse effects of long-term highly active antiretroviral therapy (HAART), that is, lipodystrophy and metabolic disorders, in a cohort of African patients. Methods: One hundred eighty HIV-1-infected patients treated with HAART for 4-9 years in Dakar and 180 age-matched and sex-matched controls were enrolled. Regional subcutaneous fat changes were assessed by physicians, and fasting blood samples were drawn. Centralization of body fat was estimated using skinfold ratio, waist ...
Tópico(s): HIV/AIDS drug development and treatment
2009 - Lippincott Williams & Wilkins | JAIDS Journal of Acquired Immune Deficiency Syndromes
Sébastien D. S. Pion, Christoph Kaiser, Fernand Boutros-Toni, Amandine Cournil, Melanie Taylor, S. E. O. Meredith, Ansgar Stüfe, I Bertocchi, Walter Kipp, Pierre‐Marie Preux, Michel Boussinesq,
We sought to evaluate the relationship between onchocerciasis prevalence and that of epilepsy using available data collected at community level.We conducted a systematic review and meta-regression of available data.Electronic and paper records on subject area ever produced up to February 2008.We searched for population-based studies reporting on the prevalence of epilepsy in communities for which onchocerciasis prevalence was available or could be estimated. Two authors independently assessed eligibility ...
Tópico(s): Parasites and Host Interactions
2009 - Public Library of Science | PLoS neglected tropical diseases
Florie Fillol, Amandine Cournil, Denis Boulanger, Badara Cissé, Cheikh Sokhna, Geoffrey Targett, Jean-François Trape, François Simondon, Brian Greenwood, Kirsten Simondon,
In sub-Saharan Africa, malaria and malnutrition are major causes of morbidity and mortality in children less than five years of age. To explore the impact of malnutrition on subsequent susceptibility to malaria, a cohort of 874 rural preschool children in Senegal was followed-up during one malaria transmission season from July through December. Data on nutritional status and Plasmodium falciparum parasitemia were collected at baseline. Malaria morbidity was monitored through weekly home visits. ...
Tópico(s): Poverty, Education, and Child Welfare
2009 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene