Antonio Meléndez‐Lazo, Carlos Ros, Cristian de la Fuente, Sònia Añor, F. Fernández, Josep Pastor,
... more papers by this authorCristian de la Fuente, Cristian de la Fuente Departament de Medicina i Cirugía Animals, Universitat Autónoma ... more papers by this authorCristian de la Fuente, Cristian de la Fuente Departament de Medicina i Cirugía Animals, Universitat Autónoma ...
Tópico(s): Veterinary Orthopedics and Neurology
2017 - Wiley | Veterinary Clinical Pathology
Roberto José‐López, Rodrigo Gutierrez‐Quintana, Cristian de la Fuente, Edgar García Manzanilla, Anna Suñol, Dolors Pi Castro, Sònia Añor, Daniel Sánchez‐Masián, F. Fernández, Emanuele Ricci, Katia Marioni‐Henry, Joan Mascort, Lara Matiasek, Kaspar Matiasek, Paul M. Brennan, Martı́ Pumarola,
Gliomas in dogs remain poorly understood.
Tópico(s): Hedgehog Signaling Pathway Studies
2021 - Wiley | Journal of Veterinary Internal Medicine
Jenifer Molina, Clementine Jean‐Philippe, Lisa Conboy, Sònia Añor, Cristian de la Fuente, Marcin Wrzosek, Andrea Spycher, Eva Luchsinger, Bettina Wenger‐Riggenbach, Patrícia Montoliu, Gualtiero Gandini, Marika Menchetti, João Ribeiro, Artur S.P. Varejão, António Ferreira, Brian M. Zanghi, Holger A. Volk,
Background Despite appropriate antiseizure drug (ASD) treatment, around two‐thirds of dogs with idiopathic epilepsy (IE) have seizures long‐term and 20–30per cent of affected dogs remain poorly controlled. Methods The current study aim is to test in a field trial the efficacy and tolerability of a commercially available diet enriched with 6.5per cent medium chain triglyceride (MCT) oil in dogs (n=21) with at least a tier 1 idiopathic epilepsy diagnosis, without cluster seizures, in 10 veterinary practices ...
Tópico(s): Epilepsy research and treatment
2020 - Wiley | Veterinary Record
JosÉ E. De La Rubia, Eraci Drehmer, José Luis Platero, María Benlloch, Jordi Caplliure‐Llopis, Carlos Villarón-Casales, N. Bernardo, Jorge Alarcón-Jiménez, Cristian de la Fuente, S. Carrera, David Sancho, Maria Pilar García-Pardo, Raquel Pascual, Marta JuÁrez, María Cuerda‐Ballester, Alfonso Forner, Sandra Sancho-Castillo, Carlos Barrios, Elena Obrador, Patricia Marchio, Rosario Salvador‐Palmer, Holly E. Holmes, Ryan W. Dellinger, Leonard Guarente, José M. Estrela,
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by progressive loss of spinal and cortical motor neurons, leading to muscular atrophy, respiratory failure, and ultimately death. There is no known cure, and the clinical benefit of the two drugs approved to treat ALS remains unclear. Novel disease-modifying therapeutics that are able to modulate the disease course are desperately needed. Our objective was to evaluate the efficacy and tolerability of Elysium ...
Tópico(s): Muscle Physiology and Disorders
2019 - Taylor & Francis | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
P. González-Herranz, Mercedes Rodríguez, Cristian de la Fuente,
Femoral osteochondritis dissecans (OCD) is a disorder of unknown aetiology and variable prognosis that causes knee pain. In this paper, the authors study the impact of lower limb malalignment on the development and prognosis of OCD.After anteroposterior (AP) and lateral radiograph and MRI of the knee, 53 cases of OCD were diagnosed. All patients were studied by standing full-length AP radiograph of the lower extremities in order to analyse the relationship between the femorotibial and mechanical axis ...
Tópico(s): Lower Extremity Biomechanics and Pathologies
2017 - SAGE Publishing | Journal of Children s Orthopaedics
Kali Lazzerini, Rodrigo Gutierrez‐Quintana, Roberto José‐López, Fraser McConnell, Rita Gonçalves, J. McMurrough, Steven De Decker, Clare Muir, Simon L. Priestnall, Lorenzo Mari, Fabio Stabile, Luisa De Risio, C Loeffler, Anna Tauro, Clare Rusbridge, Sergio Ródenas, Sònia Añor, Cristian de la Fuente, Andrea Fischer, Andreas Bruehschwein, Jacques Penderis, Julien Guevar,
Background The term meningoencephalocele ( MEC ) describes a herniation of cerebral tissue and meninges through a defect in the cranium, whereas a meningocele ( MC ) is a herniation of the meninges alone. Hypothesis/Objectives To describe the clinical features, magnetic resonance imaging ( MRI ) characteristics, and outcomes of dogs with cranial MC and MEC . Animals Twenty‐two client‐owned dogs diagnosed with cranial MC or MEC . Methods Multicentric retrospective descriptive study. Clinical records of 13 institutions ...
Tópico(s): Craniofacial Disorders and Treatments
2017 - Wiley | Journal of Veterinary Internal Medicine
Cristina Herranz, F. Fernández, Raquel Martín‐Ibáñez, Ester Blasco, Empar Crespo, Cristian de la Fuente, Sònia Añor, Rosa M. Rabanal, Josep M. Canals, Martı́ Pumarola,
Human gliomas are malignant brain tumours that carry a poor prognosis and are composed of a heterogeneous population of cells. There is a paucity of animal models available for study of these tumours and most have been created by genetic modification. Spontaneously arising canine gliomas may provide a model for the characterization of the human tumours. The present study shows that canine gliomas form a range of immunohistochemical patterns that are similar to those described for human gliomas. ...
Tópico(s): Cancer Research and Treatments
2016 - Elsevier BV | Journal of Comparative Pathology
F. Fernández, A. Deviers, Claire Dally, Giovanni Mogicato, Maxence Delverdier, Laurent Cauzinille, Kirsten Gnirs, Sònia Añor, Cristian de la Fuente, Dolors Fondevila, Martı́ Pumarola,
Gliomas are the most common primary brain tumours in humans and are associated with a poor prognosis. An accurate animal model of human glioma tumorigenesis is needed to test new treatment strategies. Dogs represent a promising model because they develop spontaneous diffusely-infiltrating gliomas. This study investigated whether spontaneous canine gliomas contain cancer stem cells previously identified in all grades of human gliomas. Twenty spontaneous cases of canine gliomas were graded according ...
Tópico(s): Glioma Diagnosis and Treatment
2015 - Elsevier BV | The Veterinary Journal
Cristian de la Fuente, Martı́ Pumarola, Sònia Añor,
An 8‐year‐old, male B oxer was examined for an acute onset of ambulatory paraparesis. Neurologic examination was consistent with a T 3‐ L 3 myelopathy. Myelography revealed an extradural spinal cord compression in the region of the T 10‐ T 13 vertebrae. On magnetic resonance ( MR ) imaging, a well‐defined epidural mass lesion was detected. The mass was mildly hyperintense on T 1‐weighted, hyperintense on T 2‐weighted and STIR images compared to normal spinal cord and enhanced strongly and homogenously. ...
Tópico(s): Neurofibromatosis and Schwannoma Cases
2013 - Wiley | Veterinary Radiology & Ultrasound
Roberto José‐López, Cristian de la Fuente, Martı́ Pumarola, Sònia Añor,
A 9-year-old male Miniature Poodle was evaluated because of progressive severe right hemiparesis, right forelimb lameness, and signs of cervical pain.A low body condition score (2/9) and popliteal lymphadenopathy were detected. Results of a CBC, serum biochemical analyses, urinalysis, cytologic examination of bone marrow and popliteal lymph node aspirates, and serum ELISA were consistent with systemic leishmaniasis. Magnetic resonance imaging of the cervical spinal cord revealed an intramedullary ...
Tópico(s): Parasites and Host Interactions
2013 - American Veterinary Medical Association | Journal of the American Veterinary Medical Association
Cristian de la Fuente, L. Monreal, J. M. Castro Cerón, Josep Pastor, Judit Viu, Sònia Añor,
Fibrinolytic activity in cerebrospinal fluid (CSF) is activated in humans by different pathologic processes.To investigate fibrinolytic activity in the CSF of dogs with neurological disorders by measuring CSF D-dimer concentrations.One hundred and sixty-nine dogs with neurological disorders, 7 dogs with systemic inflammatory diseases without central nervous system involvement (SID), and 7 healthy Beagles were included in the study. Dogs with neurological disorders included 11 with steroid-responsive ...
Tópico(s): Blood groups and transfusion
2012 - Wiley | Journal of Veterinary Internal Medicine
Roberto José‐López, Cristian de la Fuente, Sònia Añor,
Clinical signs and magnetic resonance imaging findings of multiple brain infarcts in two dogs infected with Leishmania spp. are reported. Clinical signs of intracranial dysfunction were peracute and there was no further deterioration. Magnetic resonance images of the brain were consistent with multifocal, non‐haemorrhagic, ischaemic lesions. Routine serum biochemistry revealed hyperproteinaemia and hyperglobulinaemia. Serum antibody titres were highly positive for Leishmania infantum and Leishmania ...
Tópico(s): Hemophilia Treatment and Research
2012 - Wiley | Journal of Small Animal Practice
Cristina Font, Cristian de la Fuente, Martı́ Pumarola, Ester Blasco, F. Fernández, Judit Viu, Sònia Añor,
The haemostatic system influences angiogenesis, cell growth and metastasis in solid tumours. The aim of this study was to investigate tissue factor (TF) expression, fibrin/fibrinogen and D-dimer deposition, as well as the occurrence of intravascular thrombosis (IVT) in canine intracranial meningiomas using immunohistochemistry. All but three (26/29) meningiomas expressed TF. TF immunolabelling was significantly higher in high-grade (grades II and III) than in low-grade (grade I) meningiomas. Fibrin/fibrinogen ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2015 - Elsevier BV | The Veterinary Journal
Cristian de la Fuente, Martı́ Pumarola, Ester Blasco, F. Fernández, Judit Viu, Sònia Añor,
In human gliomas, tissue factor (TF) is overexpressed, associated with the grade of malignancy and influences tumour biology. Intra-tumoural fibrin/fibrinogen deposition and activation of the fibrinolytic system also play a role in tumour cell proliferation and angiogenesis. The first aim of the present study was to investigate TF expression and the presence of fibrin/fibrinogen and D-dimers in canine glioma biopsies, graded according to the World Health Organization (WHO) classification of tumours ...
Tópico(s): Angiogenesis and VEGF in Cancer
2014 - Elsevier BV | The Veterinary Journal
Alfredo Recio, Cristian de la Fuente, Martı́ Pumarola, Yvonne Espada, Sònia Añor,
Abstract An 8‐year‐old female Boxer was examined for acute onset of seizures. On magnetic resonance imaging (MRI), an intra‐axial mass with imaging features consistent with glioma was observed in the right cerebral hemisphere. A defect in the temporal bone adjacent to the mass was observed. Postmortem computed tomography (CT) confirmed temporal bone osteolysis and necropsy demonstrated a glioblastoma with associated calvarial erosion. Although occasionally described in human medicine, to our knowledge, ...
Tópico(s): Hedgehog Signaling Pathway Studies
2017 - Wiley | Veterinary Radiology & Ultrasound
Carlos Ros, Cristian de la Fuente, Sergio Ródenas, Rosa Novellas, Judit Viu, Sonia Añor,
MRI is considered gold standard for the diagnosis of presumptive acute hydrated non‐compressive nucleus pulposus extrusions (AHNCNPE). This retrospective study describes the myelographic findings in dogs with AHNCNPE diagnosed by low‐field MRI and their association with neurological grade, need of surgical decompression and outcome. Forty‐two myelographies (21 dogs with presumptive AHNCNPE, 21 dogs with Hansen type I disc disease herniation) were blindly evaluated. Site of herniation, compression ...
Tópico(s): Spine and Intervertebral Disc Pathology
2017 - Wiley | Veterinary Record
Fernando de Mora, Cristian de la Fuente, P. Jasmin, H. Gatto, Alberto Marco, Lluís Ferrer, Alessandra Fondati, Dolors Fondevila, Rosa Torres,
Canine atopic dermatitis (AD) is a pruritic skin condition that shares many clinical and pathophysiological features with its human counterpart. A major therapeutic challenge of AD is the control of the skin inflammatory process. A detailed knowledge of the pro-inflammatory molecules involved in cell recruitment in AD would allow for a better control of the disease. We thus have studied the protein expression of P-selectin, ICAM-1 and TNF-alpha in the lesional and non-lesional skin of atopic dogs ...
Tópico(s): Exercise and Physiological Responses
2006 - Elsevier BV | Veterinary Immunology and Immunopathology
Joseph M. Wepman, Anne S. Morency,
... for a randomized crossover pilot trialBlanca Fuentes, Lydia de la Fuente-Gómez, Cristian Sempere-Iborra, Celia Delgado-Fernández, Aida Tarifa-Rodríguez, María Alonso de Leciñana, Elena de Celis-Ruiz, Raquel Gutiérrez-Zúñiga, ...
Tópico(s): Subtitles and Audiovisual Media
1963 - American Speech–Language–Hearing Association | Journal of Speech and Hearing Disorders
Juan Esteban Oyarzún, Jonathan Lagos, Mary Carmen Vázquez, Cristian Valls, Catalina de la Fuente, María-Isabel Yuseff, Alejandra Álvarez, Silvana Zanlungo,
Tópico(s): Calcium signaling and nucleotide metabolism
2019 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Jimmy Caroli, Cristian Taccioli, Adriana De La Fuente, Paolo Serafini, Silvio Bicciato,
Motivation: Aptamers are synthetic nucleic acid molecules that can bind biological targets in virtue of both their sequence and three-dimensional structure. Aptamers are selected using SELEX, Systematic Evolution of Ligands by EXponential enrichment, a technique that exploits aptamer-target binding affinity. The SELEX procedure, coupled with high-throughput sequencing (HT-SELEX), creates billions of random sequences capable of binding different epitopes on specific targets. Since this technique produces ...
Tópico(s): CRISPR and Genetic Engineering
2015 - Oxford University Press | Bioinformatics
Sarah Murphy, Alfredo Recio, Cristian de la Fuente, Ling T. Guo, G. Diane Shelton, Leigh Anne Clark,
Tópico(s): Cellular transport and secretion
2019 - Springer Science+Business Media | Human Genetics
Carlos De las Cuevas, Emílio J. Sanz, J. A. De La Fuente, Cristián Cabrera, Antonio Navareño Mateos,
Objective To assess the extent, characteristics and determinants of benzodiazepine prescription in outpatient Primary Health Care. Methods A clinical audit of a stratified random sample of Primary Health Care Centres in the seven islands and 1.6 million inhabitants region of 'Canarias' in Spain was carried out. From those centres, a random sample of 1045 clinical records was reviewed and information on diagnosis, prescription and prescribed dosages was collected in a structured questionnaire. A multivariate ...
Tópico(s): Pharmaceutical Practices and Patient Outcomes
1999 - Wiley | Pharmacoepidemiology and Drug Safety
F. Samarani, Cristian de la Fuente, Aurora Parodi, M. T. Mandara, Martı́ Pumarola, Sònia Añor,
Meningioma is the most common primary brain tumor in cats and occurs less frequently in the spinal cord. This study aimed to investigate cyclooxygenase-2 (COX-2) expression in feline meningiomas, and the possible association between COX-2 immunoreactivity and tumor grade using eight low-grade and seven high-grade meningiomas. All tumors (n = 15/15) were immunoreactive to COX-2. The expression of COX-2 was not significantly correlated with tumor grade (P = 0.22 and 0.34 for staining and intensity, respectively) ...
Tópico(s): Veterinary Oncology Research
2018 - Elsevier BV | The Veterinary Journal
Nicol Birsa, Agnieszka M Ule, Maria Giovanna Garone, Brian Tsang, Francesca Mattedi, P. Andrew Chong, Jack Humphrey, Seth Jarvis, Melis Pisiren, Oscar G. Wilkins, Micheal L. Nosella, Anny Devoy, Cristian Bodo, Rafaela Fernandez de la Fuente, Elizabeth Fisher, Alessandro Rosa, Gabriella Viero, Julie D. Forman‐Kay, Giampietro Schiavo, Pietro Fratta,
Cytoplasmic mislocalization of FUS-ALS mutants determines aberrant FMRP condensates and protein synthesis repression.
Tópico(s): Genetics and Neurodevelopmental Disorders
2021 - American Association for the Advancement of Science | Science Advances
Mohammad Jamshidi Avanaki, Abdollah Hoseini, Shahram Vahdani, Cristian de Santos, Albert de la Fuente,
In recent years, application of fibers as a replacement for conventional reinforcement in segmented lined tunnels has gained great interest due to resulting cost and time savings. In seismically active regions, the seismic vulnerability of underground tunnels is of great concern. The aim of this paper is to investigate the effects of different composites of Steel FRC (SFRC), as the tunnel’s lining material, on its seismic vulnerability, compared to each other and to that of unreinforced and conventionally ...
Tópico(s): Concrete Corrosion and Durability
2018 - Elsevier BV | Tunnelling and Underground Space Technology
Produção Nacional
Revisado por pares
Rodrigo Ramírez‐Campillo, Cristian Martínez‐Salazar, Carlos De la Fuente, Eduardo Lusa Cadore, Mário C. Marques, Fábio Yuzo Nakamura, Irineu Loturco, Alexis Caniuqueo Vargas, Rodrigo Cañas, Míkel Izquierdo,
Older women participated in a 12-week high-speed resistance training program under two supervisor-to-subject ratio methods (i.e., high versus low supervision) to assess its effects on muscle strength, power, functional performance, and quality of life assessed before (T1) and after (T2) intervention. Women were divided into either the control group (CG, n = 15), high supervision group (HSG, n = 30), or low supervision group (LSG, n = 28). The training program included exercises requiring high-speed concentric ...
Tópico(s): Cardiovascular and exercise physiology
2016 - Human Kinetics | Journal of Aging and Physical Activity
Skylar Kelsven, Camilo de la Fuente‐Sandoval, Cristian L. Achim, Francisco Reyes-Madrigal, Heline Mirzakhanian, Isabel Domingues, Kristin S. Cadenhead,
Research examining the role of inflammation in psychosis has produced inconsistent results. Variables that influence inflammation, including antipsychotic medication, are inconsistently controlled across studies and variation of inflammatory analytes across stages of psychosis may also influence findings. The purpose of this study was to assess for evidence of immuno-inflammatory dysregulation across the stages of early psychosis. We examined a immuno-inflammatory analytes in subjects at clinical ...
Tópico(s): Schizophrenia research and treatment
2020 - Elsevier BV | Schizophrenia Research
Raquel Puig‐Lozano, Antonio Fernández, Eva Sierra, Pedro Saavedra, Cristian M. Suárez‐Santana, Jesús de la Fuente, Josué Díaz‐Delgado, Ana Godinho, Natalia García‐Álvarez, Daniele Zucca, Aina Xuriach, Marina Arregui, Idaira Felipe-Jiménez, Francesco Consoli, Pablo Díaz-Santana, Simone Segura-Göthlin, Nakita Câmara, Miguel A. Rivero, Simona Sacchini, Yara Bernaldo de Quirós, Manuel Arbelo,
Estimating cetacean interactions with fishery activities is challenging. Bycatch and chronic entanglements are responsible for thousands of cetacean deaths per year globally. This study represents the first systematic approach to the postmortem investigation of fishery interactions in stranded cetaceans in the Canary Islands. We retrospectively studied 586 cases necropsied between January 2000 and December 2018. Of the cases with a known cause of death, 7.4% (32/453) were due to fishery interactions, ...
Tópico(s): Maritime Navigation and Safety
2020 - Frontiers Media | Frontiers in Veterinary Science
Cristian Bereanu, Daniel de la Fuente, Alfonso Romero, Pedro J. Torres,
We provide sufficient conditions for the existence of a uniparametric family of entire spacelike graphs with prescribed mean curvature in a Friedmann–Lemaître–Robertson–Walker spacetime with flat fiber. The proof is based on the analysis of the associated homogeneous Dirichlet problem on a Euclidean ball together with suitable bounds for the gradient which permit the prolongability of the solution to the whole space.
Tópico(s): Geometry and complex manifolds
2016 - World Scientific | Communications in Contemporary Mathematics
Carlos Ros, Cristian de la Fuente, Martı́ Pumarola, Sònia Añor,
A 13-year-old, female spayed, crossbreed dog of 32 kg was presented for evaluation of peracute onset of non-ambulatory tetraparesis after chewing an electrical wire. Neurological examination was consistent with a C1-C5 myelopathy. Magnetic resonance imaging revealed a focal intramedullary lesion over the C2-C3 vertebral bodies, which was confirmed to be an acute focal necrotising poliomyelopathy with subarachnoid and subdural haemorrhages on postmortem examination. This report describes the clinical, ...
Tópico(s): Restraint-Related Deaths
2015 - Wiley | Journal of Small Animal Practice