Benjamin B. Shields, Chad V. Pecot, Hua Gao, Elizabeth A. McMillan, Malia B. Potts, Christa Nagel, Scott C. Purinton, Ying Wang, Cristina Ivan, Hyun Seok Kim, Robert Borkowski, Shaheen Khan, Cristian Rodriguez‐Aguayo, Gabriel López-Berestein, Jayanthi Lea, Adi F. Gazdar, Keith Baggerly, Anil K. Sood, Michael A. White,
... USA Search for more papers by this author Cristian Rodriguez-Aguayo Cristian Rodriguez-Aguayo Center for RNA interference and Non-Coding ... USA Search for more papers by this author Cristian Rodriguez-Aguayo Cristian Rodriguez-Aguayo Center for RNA interference and Non-Coding ... Hyun Seok Kim5, Robert J Borkowski1, Shaheen Khan6, Cristian Rodriguez-Aguayo2, Gabriel Lopez-Berestein2, Jayanthi Lea3, Adi Gazdar7, ...
Tópico(s): MicroRNA in disease regulation
2015 - Springer Nature | Molecular Systems Biology
Mohammed H. Rashed, Pınar Kanlikilicer, Cristian Rodriguez‐Aguayo, Martin Pichler, Recep Bayraktar, Emine Bayraktar, Cristina Ivan, Justyna Filant, Andreia Silva, Burcu Aslan, Merve Denizli, Rahul Mitra, Bülent Özpolat, George A. Călin, Anil K. Sood, Mohamed F. Abd‐Ellah, Gouda K. Helal, Gabriel Lopez Berestein,
... H. Rashed 1, 4 , Pinar Kanlikilicer 1, 2 , Cristian Rodriguez-Aguayo 1, 2 , Martin Pichler 7 , Recep Bayraktar ...
Tópico(s): Circular RNAs in diseases
2017 - Impact Journals LLC | Oncotarget
Guillermo N. Armaiz-Peña, Vianey González-Villasana, Archana S. Nagaraja, Cristian Rodriguez‐Aguayo, Nouara C. Sadaoui, Rebecca L. Stone, Koji Matsuo, Heather J. Dalton, Rebecca A. Previs, Nicholas B. Jennings, Piotr L. Dorniak, Jean M. Hansen, Jesusa M.G. Arevalo, Steve W. Cole, Susan K. Lutgendorf, Anil K. Sood, Gabriel López-Berestein,
... Vianey Gonzalez-Villasana 2 , Archana S. Nagaraja 1 , Cristian Rodriguez-Aguayo 2 , Nouara C. Sadaoui 1 , Rebecca L. ...
Tópico(s): Neuropeptides and Animal Physiology
2014 - Impact Journals LLC | Oncotarget
Olivia D. Lara, Emine Bayraktar, Paola Amero, Shaolin Ma, Cristina Ivan, Wei Hu, Ying Wang, Lingegowda S. Mangala, Prasanta Dutta, Pratip K. Bhattacharya, Ana Tari Ashizawa, Gabriel López-Berestein, Cristian Rodriguez‐Aguayo, Anil K. Sood,
... Ashizawa 6 , Gabriel Lopez-Berestein 2 , 4 , 7 , Cristian Rodriguez-Aguayo 2 , 4 and Anil K. Sood 1 , ... to: Anil K. Sood, email: asood@mdanderson.org Cristian Rodriguez-Aguayo, email: CRodriguez2@mdanderson.org Keywords: ovarian cancer; ...
Tópico(s): RNA modifications and cancer
2020 - Impact Journals LLC | Oncotarget
María Isabel Lamas Galdo, J. D. Rodríguez, Cristian Rodríguez, Patricia González,
Three-dimensional cfd analysis to study the thrust and efficiency of a biologically-inspired marine propulsorAquatic animals, which are the result of many millions of years of evolutionary optimization, are very quick, efficient, robust, and versatile. Accordingly, biologically-inspired mechanisms which emulate the movement of animals have recently become very popular. For the efficient design of a propulsion system it is very important to analyze the fluid flow in detail. CFD (Computational Fluid ...
Tópico(s): Underwater Vehicles and Communication Systems
2011 - De Gruyter Open | Polish Maritime Research
Marco Napoli, Avinashnarayan Venkatanarayan, Payal Raulji, Brooke A. Meyers, William Norton, Lingegowda S. Mangala, Anil K. Sood, Cristian Rodriguez‐Aguayo, Gabriel López-Berestein, Harina Vin, Madeleine Duvic, Michael Tetzlaff, Jonathan L. Curry, Alain H. Rook, Hussein A. Abbas, Cristian Coarfa, Preethi H. Gunaratne, Kenneth Y. Tsai, Elsa R. Flores,
ΔNp63 is an oncogenic member of the p53 family and acts to inhibit the tumor-suppressive activities of the p53 family. By performing a chemical library screen, we identified histone deacetylase inhibitors (HDACi) as agents reducing ΔNp63 protein stability through the E3 ubiquitin ligase, Fbw7. ΔNp63 inhibition decreases the levels of its transcriptional target, DGCR8, and the maturation of let-7d and miR-128, which we found to be critical for HDACi function in vitro and in vivo. Our work identified ...
Tópico(s): Protein Degradation and Inhibitors
2016 - Cell Press | Cancer Cell
Yiyan Zheng, Ritika Sethi, Lingegowda S. Mangala, C R Taylor, Juliet Goldsmith, Ming Wang, Kenta Masuda, Eli M. Carrami, David Mannion, Fabrizio Miranda, Sandra Herrero‐González, Karin Hellner, Fiona Chen, Abdulkhaliq Alsaadi, Ashwag Albukhari, Donatien Chedom Fotso, Christopher Yau, Dahai Jiang, Sunila Pradeep, Cristian Rodriguez‐Aguayo, Gabriel López-Berestein, Stefan Knapp, Nathanael S. Gray, Leticia Campo, Kevin A. Myers, Sunanda Dhar, David Ferguson, Robert C. Bast, Anil K. Sood, F. von Delft, Ahmed A. Ahmed,
Abstract Though used widely in cancer therapy, paclitaxel only elicits a response in a fraction of patients. A strong determinant of paclitaxel tumor response is the state of microtubule dynamic instability. However, whether the manipulation of this physiological process can be controlled to enhance paclitaxel response has not been tested. Here, we show a previously unrecognized role of the microtubule-associated protein CRMP2 in inducing microtubule bundling through its carboxy terminus. This activity ...
Tópico(s): Glycosylation and Glycoproteins Research
2018 - Nature Portfolio | Nature Communications
Maitri Shah, Manuela Ferracin, Valentina Pileczki, Baoqing Chen, Roxana S. Redis, Linda Fabris, Xinna Zhang, Cristina Ivan, Masayoshi Shimizu, Cristian Rodriguez‐Aguayo, Mihnea P. Dragomir, Katrien Van Roosbroeck, Maria Inês Almeida, Maria Ciccone, Daniela Nedelcu, María Angélica Cortez, Taghi Manshouri, Steliana Calin, Muharrem Müftüoğlu, Pinaki P. Banerjee, Mustafa H. Badiwi, Jan Parker‐Thornburg, Asha S. Multani, James W. Welsh, Marcos R. Estecio, Hui Ling, Ciprian Tomuleasa, Delia Dima, Hui Yang, Héctor M. Álvarez, M. James You, Milan Radovich, Elizabeth J. Shpall, Muller Fabbri, Katy Rezvani, Leonard Girnita, Ioana Berindan‐Neagoe, Anirban Maitra, Srđan Verstovšek, Riccardo Fodde, Carlos E. Bueso‐Ramos, Mihai Gagea, Guillermo Garcia‐Manero, George A. Călin,
The cancer-risk-associated rs6983267 single nucleotide polymorphism (SNP) and the accompanying long noncoding RNA CCAT2 in the highly amplified 8q24.21 region have been implicated in cancer predisposition, although causality has not been established. Here, using allele-specific CCAT2 transgenic mice, we demonstrate that CCAT2 overexpression leads to spontaneous myeloid malignancies. We further identified that CCAT2 is overexpressed in bone marrow and peripheral blood of myelodysplastic/myeloproliferative ...
Tópico(s): RNA modifications and cancer
2018 - Cold Spring Harbor Laboratory Press | Genome Research
Darı́o G. Pérez, Pablo Cornejo, Cristian Rodríguez, F. Concha,
Although roping in hydrocyclones is a problem that has been studied by many researchers, we do not yet have a theory that relates all the variables involved. Several experimental works with different approaches such as mechanical energy balance, work on hydrocyclones with water only and hydrocyclone air core measurements with different instruments in the laboratory and plant have attempted to explain the roping phenomenon. They have addressed design variables such as apex to vortex diameters and ...
Tópico(s): Aerosol Filtration and Electrostatic Precipitation
2018 - Elsevier BV | Minerals Engineering
Cristian Rodríguez-Tinoco, Marzena Rams‐Baron, K. L. Ngai, Karolina Jurkiewicz, J. Rodríguez‐Viejo, Marian Paluch,
Secondary relaxations are fundamental for their impact in the properties of glasses and for their inseparable connection to the structural relaxation. Understanding their density dependence and aging behavior is key to fully address the nature of glasses. Ultrastable glasses establish a new benchmark to study the characteristics of secondary relaxations, since their enthalpy and density levels are unattainable by other routes. Here, we use dielectric spectroscopy at ambient and elevated pressures ...
Tópico(s): Liquid Crystal Research Advancements
2018 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Pınar Kanlikilicer, Recep Bayraktar, Merve Denizli, Mohammed H. Rashed, Cristina Ivan, Burcu Aslan, Rahul Mitra, Kübra Karagoz, Emine Bayraktar, Xinna Zhang, Cristian Rodriguez‐Aguayo, Amr Ahmed El‐Arabey, Nermin Kahraman, Seyda Baydogan, Özgür Özkayar, Michael L. Gatza, Bülent Özpolat, George A. Călin, Anil K. Sood, Gabriel López-Berestein,
BackgroundCirculating miRNAs are known to play important roles in intercellular communication. However, the effects of exosomal miRNAs on cells are not fully understood.MethodsTo investigate the role of exosomal miR-1246 in ovarian cancer (OC) microenvironment, we performed RPPA as well as many other in vitro functional assays in ovarian cancer cells (sensitive; HeyA8, Skov3ip1, A2780 and chemoresistant; HeyA8-MDR, Skov3-TR, A2780-CP20). Therapeutic effect of miR-1246 inhibitor treatment was tested ...
Tópico(s): Circular RNAs in diseases
2018 - Elsevier BV | EBioMedicine
K. L. Ngai, Marian Paluch, Cristian Rodríguez-Tinoco,
Coupling-Model-based theoretical explanation of the minor change of JG β-relaxation achieved by ultrastability in contrast to the dramatic change in α-relaxation.
Tópico(s): Spectroscopy and Quantum Chemical Studies
2018 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Adrián González-González, Esperanza Muñoz‐Muela, Juan Antonio Marchal, Francisca E. Cara, Maria P. Molina, Marina Cruz-Lozano, Gema Jiménez, Akanksha Verma, Alberto Ramírez, Wei Qian, Wen Chen, Anthony J. Kozielski, Olivier Elemento, María D. Martín-Salvago, Rafael J. Luque, Carmen Rosa‐Garrido, David Landeira, María Quintana-Romero, Roberto R. Rosato, María Ángel García, César L. Ramírez-Tortosa, Hanna Kim, Cristian Rodriguez‐Aguayo, Gabriel López-Berestein, Anil K. Sood, José A. Lorente, Pedro Sánchez‐Rovira, Jenny C. Chang, Sergio Granados‐Principal,
Abstract Purpose: On the basis of the identified stress-independent cellular functions of activating transcription factor 4 (ATF4), we reported enhanced ATF4 levels in MCF10A cells treated with TGFβ1. ATF4 is overexpressed in patients with triple-negative breast cancer (TNBC), but its impact on patient survival and the underlying mechanisms remain unknown. We aimed to determine ATF4 effects on patients with breast cancer survival and TNBC aggressiveness, and the relationships between TGFβ and ATF4. ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2018 - American Association for Cancer Research | Clinical Cancer Research
Guermarie Velázquez-Torres, Einav Shoshan, Cristina Ivan, Li Huang, Enrique Fuentes‐Mattei, Harrison Paret, Sun Jin Kim, Cristian Rodriguez‐Aguayo, Victoria K. Xie, Denise Brooks, Steven J.M. Jones, A. Gordon Robertson, George A. Călin, Gabriel López-Berenstein, Anil K. Sood, Menashe Bar‐Eli,
Previously we have reported that metastatic melanoma cell lines and tumor specimens have reduced expression of ADAR1 and consequently are impaired in their ability to perform A-to-I microRNA (miRNA) editing. The effects of A-to-I miRNAs editing on melanoma growth and metastasis are yet to be determined. Here we report that miR-378a-3p is undergoing A-to-I editing only in the non-metastatic but not in metastatic melanoma cells. The function of the edited form is different from its wild-type counterpart. ...
Tópico(s): CRISPR and Genetic Engineering
2018 - Nature Portfolio | Nature Communications
Peijing Zhang, Zhenna Xiao, Shouyu Wang, Mutian Zhang, Yongkun Wei, Qinglei Hang, Jongchan Kim, Fan Yao, Cristian Rodriguez‐Aguayo, Baochau N. Ton, Minjung Lee, Yumeng Wang, Zhicheng Zhou, Liyong Zeng, Xiaoyu Hu, Sarah E. Lawhon, Ashley N. Siverly, Xiaohua Su, Jia Li, Xiaoping Xie, Xuhong Cheng, Liang-Chiu Liu, Hui-Wen Chang, Shu‐Fen Chiang, Gabriel López-Berestein, Anil K. Sood, Junjie Chen, M. James You, Shao‐Cong Sun, Han Liang, Yun Huang, Xianbin Yang, Deqiang Sun, Yutong Sun, Mien‐Chie Hung, Li Ma,
Although EZH2 enzymatic inhibitors have shown antitumor effects in EZH2-mutated lymphoma and ARID1A-mutated ovarian cancer, many cancers do not respond because EZH2 can promote cancer independently of its histone methyltransferase activity. Here we identify ZRANB1 as the EZH2 deubiquitinase. ZRANB1 binds, deubiquitinates, and stabilizes EZH2. Depletion of ZRANB1 in breast cancer cells results in EZH2 destabilization and growth inhibition. Systemic delivery of ZRANB1 small interfering RNA (siRNA) ...
Tópico(s): Genomics and Chromatin Dynamics
2018 - Cell Press | Cell Reports
Manuel Moncada, Cristian Rodríguez,
Vibrating screens are critical machines used for size classification in mineral processing. Their proper operation, including accurate vibration movement and slope angle, can provide the benefits of energy savings and cost reductions in the screening process and the whole mining process. Dynamic models of the vibrating screen movement available in the literature do not simulate ore motion or its interaction with screen decks. The discrete element method (DEM) allows for the calculation of the dynamic ...
Tópico(s): Tunneling and Rock Mechanics
2018 - Hindawi Publishing Corporation | Shock and Vibration
Lingegowda S. Mangala, Hongyu Wang, Dahai Jiang, Sherry Y. Wu, Anoma Somasunderam, David E. Volk, G.L. Lokesh, Xin Li, Sunila Pradeep, Xianbin Yang, Monika Haemmerle, Cristian Rodriguez‐Aguayo, Archana S. Nagaraja, Rajesha Rupaimoole, Emine Bayraktar, Recep Bayraktar, Li Li, Takemi Tanaka, Wei Hu, Cristina Ivan, Kshipra M. Gharpure, Michael H. McGuire, Varatharasa Thiviyanathan, Xinna Zhang, Sourindra N. Maiti, Nataliya Bulayeva, Hyun Jin Choi, Piotr L. Dorniak, Laurence J.N. Cooper, Kevin P. Rosenblatt, Gabriel López-Berestein, David G. Gorenstein, Anil K. Sood,
The Editors recently became aware that the Endo40 and Endo42 samples in Supplemental Figure 4B appear to be similar.Additionally, in Supplemental Figure 9, the CH and CH/Endo28-NPs for the heart tissue appear to be the same.The Editorial Board is pursuing further investigation of this matter, and we will inform our readers of the outcome when the investigation is complete.
Tópico(s): RNA Research and Splicing
2018 - American Society for Clinical Investigation | JCI Insight
Takeshi Hisamatsu, Michael H. McGuire, Sherry Y. Wu, Rajesha Rupaimoole, Sunila Pradeep, Emine Bayraktar, Kyunghee Noh, Wei Hu, Jean M. Hansen, Yasmin Lyons, Kshipra M. Gharpure, Archana S. Nagaraja, Lingegowda S. Mangala, Takashi MITAMURA, Cristian Rodriguez‐Aguayo, Young‐Gyu Eun, Johnathon L. Rose, Geoffrey Bartholomeusz, Cristina Ivan, Ju‐Seog Lee, Koji Matsuo, Michael Frumovitz, Kwong‐Kwok Wong, Gabriel López-Berestein, Anil K. Sood,
For mucinous ovarian cancer (MOC), standard platinum-based therapy is largely ineffective. We sought to identify possible mechanisms of oxaliplatin resistance of MOC and develop strategies to overcome this resistance. A kinome-based siRNA library screen was carried out using human MOC cells to identify novel targets to enhance the efficacy of chemotherapy. In vitro and in vivo validations of antitumor effects were performed using mouse MOC models. Specifically, the role of PRKRA/PACT in oxaliplatin ...
Tópico(s): Chromatin Remodeling and Cancer
2018 - American Association for Cancer Research | Molecular Cancer Therapeutics
Joan Ràfols‐Ribé, Ana Vila-Costa, Cristian Rodríguez-Tinoco, A. F. Lopeandía, J. Rodríguez‐Viejo, Marta González-Silveira,
Physical vapour deposition has emerged as the technique to obtain glasses of unbeatable stability. However, vapour deposited glasses exhibit a different transformation mechanism to ordinary glasses produced from liquid. Vapour deposited glasses of different thermodynamic stability, from ultrastable to those similar to ordinary glasses, transform into the liquid state via front propagation starting at the most mobile surfaces/interfaces, at least for the first stages of the transformation, eventually ...
Tópico(s): Phase-change materials and chalcogenides
2018 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Myrthala Moreno‐Smith, Jyotsna B. Halder, Paul S. Meltzer, Tamas A. Gonda, Lingegowda S. Mangala, Rajesha Rupaimoole, Chunhua Lü, Archana S. Nagaraja, Kshipra M. Gharpure, Yu Kang, Cristian Rodriguez‐Aguayo, Pablo E. Vivas‐Mejía, Behrouz Zand, Rosemarie Schmandt, Hua Wang, Robert R. Langley, Nicholas B. Jennings, Cristina Ivan, Jeremy E. Coffin, Guillermo N. Armaiz-Peña, Justin Bottsford-Miller, Sang Bae Kim, Margaret S. Halleck, Mary J.C. Hendrix, William G. Bornman, Menashe Bar‐Eli, Ju‐Seog Lee, Zahid H. Siddik, Gabriel López-Berestein, Anil K. Sood,
Platinum compounds display clinical activity against a wide variety of solid tumors; however, resistance to these agents is a major limitation in cancer therapy. Reduced platinum uptake and increased platinum export are examples of resistance mechanisms that limit the extent of DNA damage. Here, we report the discovery and characterization of the role of ATP11B, a P-type ATPase membrane protein, in cisplatin resistance. We found that ATP11B expression was correlated with higher tumor grade in human ...
Tópico(s): Trace Elements in Health
2018 - American Society for Clinical Investigation | Journal of Clinical Investigation
Julie K. Allen, Guillermo N. Armaiz-Peña, Archana S. Nagaraja, Nouara C. Sadaoui, Tatiana Ortíz, Robert Dood, Merve Ozcan, Danielle M. Herder, Monika Haemmerle, Kshipra M. Gharpure, Rajesha Rupaimoole, Rebecca A. Previs, Sherry Y. Wu, Sunila Pradeep, Xiaoyun Xu, Hee Dong Han, Behrouz Zand, Heather J. Dalton, Morgan Taylor, Wei Hu, Justin Bottsford-Miller, Myrthala Moreno‐Smith, Yu Kang, Lingegowda S. Mangala, Cristian Rodriguez‐Aguayo, Vasudha Sehgal, Erika L. Spaeth, Prahlad T. Ram, Stephen T.C. Wong, Frank C. Marini, Gabriel López-Berestein, Steve W. Cole, Susan K. Lutgendorf, Mariella De Biasi, Anil K. Sood,
Mounting clinical and preclinical evidence supports a key role for sustained adrenergic signaling in the tumor microenvironment as a driver of tumor growth and progression. However, the mechanisms by which adrenergic neurotransmitters are delivered to the tumor microenvironment are not well understood. Here we present evidence for a feed-forward loop whereby adrenergic signaling leads to increased tumoral innervation. In response to catecholamines, tumor cells produced brain-derived neurotrophic ...
Tópico(s): Pediatric Pain Management Techniques
2018 - American Association for Cancer Research | Cancer Research
Kshipra M. Gharpure, Sunila Pradeep, Marta Sans, Rajesha Rupaimoole, Cristina Ivan, Sherry Y. Wu, Emine Bayraktar, Archana S. Nagaraja, Lingegowda S. Mangala, Xinna Zhang, Monika Haemmerle, Wei Hu, Cristian Rodriguez‐Aguayo, Michael H. McGuire, Celia Sze Ling Mak, Xiuhui Chen, Michelle Tran, Alejandro Villar‐Prados, Guillermo N. Armaiz-Peña, Ragini Kondetimmanahalli, Ryan Nini, Pranavi Koppula, Prahlad T. Ram, Jinsong Liu, Gabriel López-Berestein, Keith Baggerly, Lívia S. Eberlin, Anil K. Sood,
The standard treatment for high-grade serous ovarian cancer is primary debulking surgery followed by chemotherapy. The extent of metastasis and invasive potential of lesions can influence the outcome of these primary surgeries. Here, we explored the underlying mechanisms that could increase metastatic potential in ovarian cancer. We discovered that FABP4 (fatty acid binding protein) can substantially increase the metastatic potential of cancer cells. We also found that miR-409-3p regulates FABP4 ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2018 - Nature Portfolio | Nature Communications
Recep Bayraktar, Cristina Ivan, Emine Bayraktar, Pınar Kanlikilicer, Nashwa Kabil, Nermin Kahraman, Hamada A. Mokhlis, Didem Karakaş, Cristian Rodriguez‐Aguayo, Ahmet Arslan, Jianting Sheng, Stephen T.C. Wong, Gabriel López-Berestein, George A. Călin, Bülent Özpolat,
Purpose: Recent studies indicated that dysregulation of noncoding RNAs (ncRNA) such as miRNAs is involved in pathogenesis of various human cancers. However, the molecular mechanisms underlying miR-34a are not fully understood in triple-negative breast cancer (TNBC).Experimental Design: We performed in vitro functional assays on TNBC cell lines to investigate the role of miR-34a in FOXM1/eEF2K signaling axis. TNBC tumor xenograft models were used for in vivo therapeutic delivery of miR-34a.Results: ...
Tópico(s): Cancer-related molecular mechanisms research
2018 - American Association for Cancer Research | Clinical Cancer Research
Cristian Rodríguez-Tinoco, K. L. Ngai, Marzena Rams‐Baron, J. Rodríguez‐Viejo, Marian Paluch,
Secondary relaxations persistent in the glassy state after structural arrest are especially relevant for the properties of the glass. A major thrust in research in dynamics of glass-forming liquids is to identify what secondary relaxations exhibit a connection to the structural relaxation and are hence more relevant. Via the Coupling Model, secondary relaxations having such connection have been identified by properties similar to the primitive relaxation of the Coupling Model and are called the ...
Tópico(s): Phase Equilibria and Thermodynamics
2018 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Michael J. Wagner, Rahul Mitra, Mark J. McArthur, Wallace B. Baze, Kirstin Barnhart, Sherry Y. Wu, Cristian Rodriguez‐Aguayo, Xinna Zhang, Robert L. Coleman, Gabriel López-Berestein, Anil K. Sood,
To address the need for efficient and biocompatible delivery systems for systemic siRNA delivery, we developed 1,2-Dioleoyl-sn-Glycero-3-Phosphatidylcholine (DOPC) nanoliposomal EphA2-targeted therapeutic (EPHARNA). Here, we performed safety studies of EPHARNA in murine and primate models. Single dosing of EPHARNA was tested at 5 concentrations in mice (N = 15 per group) and groups were sacrificed on days 1, 14, and 28 for evaluation of clinical pathology and organ toxicity. Multiple dosing of EPHARNA ...
Tópico(s): MicroRNA in disease regulation
2017 - American Association for Cancer Research | Molecular Cancer Therapeutics
Yolanda E. Peréz‐Beltrán, Eduardo Mendeleev Becerra-Verdín, Sonia G. Sáyago‐Ayerdi, Nuria Elizabeth Rocha‐Guzmán, Emma G. García-López, Alfonso Castañeda-Martínez, Rubén Montalvo‐González, Cristian Rodriguez‐Aguayo, Efigenia Montalvo‐González,
The nutritional characteristics and bioactive compound content in purees elaborated with guava-strawberry, guava-blackberry, guava-soursop or guava-passion fruit were evaluated as well as their effect on biochemical markers of hyperglycemic and hypercholesterolemic rats. Over a 4-week period, the effects of each puree were examined. All purees presented a high content of indigestible fraction (70.6–82.3 g/100 g), vitamin C (500–534.6 mg/100 g), soluble polyphenols (32.8–33 mg/g) and antioxidant capacity. ...
Tópico(s): Phytochemicals and Antioxidant Activities
2017 - Elsevier BV | Journal of Functional Foods
Cristian Rodriguez‐Aguayo, Paloma del C. Monroig, Roxana S. Redis, Emine Bayraktar, Maria Inês Almeida, Cristina Ivan, Enrique Fuentes‐Mattei, Mohammed H. Rashed, Arturo Chávez‐Reyes, Bülent Özpolat, Rahul Mitra, Anil K. Sood, George A. Călin, Gabriel López-Berestein,
Abstract The regulation of microRNA (miRNA) biogenesis, function and degradation involves a range of mechanisms, including interactions with RNA-binding proteins. The potential contribution of regulatory miRNAs to the expression of these RNA interactor proteins that could control other miRNAs expression is still unclear. Here we demonstrate a regulatory circuit involving oncogenic and tumor-suppressor miRNAs and an RNA-binding protein in a chemotherapy-resistant ovarian cancer model. We identified ...
Tópico(s): Cancer-related molecular mechanisms research
2017 - Springer Nature | Cell Discovery
María Isabel Lamas Galdo, Cristian Rodríguez,
Nowadays, the even increasing stringent environmental legislations have promoted interest in alternative fuels for internal combustion engines. Particularly, hydrogen is becoming a promising fuel due to its high specific energy and low emissions production. Environmentally, the main disadvantage of hydrogen is the high level of nitrogen oxides (NOx) which produces. In this regard, this work proposes a NOx reduction method which consists on direct injection of ammonia (NH3) into the combustion chamber. ...
Tópico(s): Vehicle emissions and performance
2017 - Elsevier BV | International Journal of Hydrogen Energy
Xiuhui Chen, Lingegowda S. Mangala, Cristian Rodriguez‐Aguayo, Xianchao Kong, Gabriel López-Berestein, Anil K. Sood,
RNA interference (RNAi) is considered a highly specific approach for gene silencing and holds tremendous potential for treatment of various pathologic conditions such as cardiovascular diseases, viral infections, and cancer. Although gene silencing approaches such as RNAi are widely used in preclinical models, the clinical application of RNAi is challenging primarily because of the difficulty in achieving successful systemic delivery. Effective delivery systems are essential to enable the full therapeutic ...
Tópico(s): Animal Virus Infections Studies
2017 - Springer Science+Business Media | Cancer and Metastasis Reviews
Yi Liu, Dong Soon Choi, Jianting Sheng, Joe Ensor, Diana H. Liang, Cristian Rodriguez‐Aguayo, Amanda Polley, Stephen C. Benz, Olivier Elemento, Akanksha Verma, Yang Cong, Helen Wong, Wei Qian, Zheng Li, Sergio Granados‐Principal, Gabriel López-Berestein, Melissa D. Landis, Roberto R. Rosato, Bhuvanesh Dave, Stephen T.C. Wong, Dario Marchetti, Anil K. Sood, Jenny C. Chang,
Here, we show that HEMATOLOGICAL AND NEUROLOGICAL EXPRESSED 1-LIKE (HN1L) is a targetable breast cancer stem cell (BCSC) gene that is altered in 25% of whole breast cancer and significantly correlated with shorter overall or relapse-free survival in triple-negative breast cancer (TNBC) patients. HN1L silencing reduced the population of BCSCs, inhibited tumor initiation, resensitized chemoresistant tumors to docetaxel, and hindered cancer progression in multiple TNBC cell line-derived xenografts. Additionally, ...
Tópico(s): RNA modifications and cancer
2017 - Elsevier BV | Stem Cell Reports