Limpar
5 resultados

Acesso aberto

Tipo do recurso

Ano de criação

Produção nacional

Revisado por pares

Áreas

Idioma

Editores

Artigo Acesso aberto Revisado por pares

Marco Erreni, Imran Siddiqui, Giulia Marelli, Fabio Grizzi, Paolo Bianchi, Diego Morone, Federica Marchesi, Giuseppe Celesti, Samantha Pesce, Andrea Doni, Cristiano Rumio, Massimo Roncalli, Luigi Laghi, Alberto Mantovani, Paola Allavena,

Human colorectal cancer (CRC) is a frequent neoplasia in Western countries, and its metastatic progression is a major cause of cancer-related death. In search of specific molecules upregulated in CRC, with possible clinical relevance, we performed a differential gene-profiling analysis in surgery-derived CRC samples and adjacent uninvolved intestinal mucosa. The chemokine CX3CL1 and its specific receptor CX3CR1 were significantly upregulated in tumors. Higher expression of CX3CL1 and CX3CR1 was confirmed ...

Tópico(s): Cell Adhesion Molecules Research

2015 - American Association of Immunologists | The Journal of Immunology

Artigo Acesso aberto Revisado por pares

Stefania Vetrano, María Rescigno, Maria Rosaria, Carmen Correale, Cristiano Rumio, Andrea Doni, Massimo Claudio Fantini, Andreas Sturm, Elena Monica Borroni, Alessandro Repici, Massimo Locati, Alberto Malesci, Elisabetta Dejana, Silvio Danese,

Background & Aims: Junctional adhesion molecule-A (JAM-A) is localized at the tight junctions and controls leukocyte migration into the tissues. However, its functional role in inflammatory bowel disease (IBD) is unexplored. Methods: Control, Crohn's disease (CD), and ulcerative colitis (UC) tissue specimens were studied for JAM-A expression, as well as the colon of mice given dextran sodium sulfate (DSS). Wild-type and JAM-A-/-, Tie-2-Cre-JAM-A-/- (endothelial/hematopoietic-specific JAM inactivation) mice ...

Tópico(s): Immune Response and Inflammation

2008 - Elsevier BV | Gastroenterology

Artigo Revisado por pares

Giacomo Todeschini,

... di Bonaventura, che pietas e charitas in quanto doni divini, se, da un lato avvicinano l'uomo ...

Tópico(s): Historical Economic and Legal Thought

2002 - St. Bonaventure University | Franciscan studies