Tiago V. Augusto, Cristina Amaral, Cristina Ferreira Almeida, Natércia Teixeira, Georgina Correia‐da‐Silva,
Estrogen receptor-positive (ER+) breast carcinomas are the most common subtype, corresponding to 60% of the cases in premenopausal and 75% in postmenopausal women. The third-generation of aromatase inhibitors (AIs), the non-steroidal Anastrozole (Ana) and Letrozole (Let) and the steroidal Exemestane (Exe), are considered a first-line endocrine therapy for postmenopausal women. Despite their clinical success, the development of resistance is the major setback in clinical practice. Nevertheless, the lack ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2021 - Elsevier BV | Molecular and Cellular Endocrinology
Produção Nacional
Revisado por pares
Aparecida Yulie Yamamoto, Marisa Márcia Mussi‐Pinhata, Myriam de Lima Isaac, Fabiana Amaral, Cristina Gardonyi Carvalheiro, Davi Casale Aragon, Alessandra Kerli da Silva Manfredi, Suresh B. Boppana, William J. Britt,
Background: The burden of congenital cytomegalovirus (CMV)-associated sensorineural hearing loss (SNHL) in populations with CMV seroprevalence approaching 100% is unknown. The purpose of this study was to assess the rate, associated factors, and predictors of SNHL in CMV-infected infants identified by newborn screening in a highly seropositive maternal population. Methods: Newborns with positive saliva CMV-DNA that was confirmed by virus isolation in the first 2 weeks of life were enrolled in a prospective ...
Tópico(s): Neonatal Health and Biochemistry
2011 - Lippincott Williams & Wilkins | The Pediatric Infectious Disease Journal
Produção Nacional
Revisado por pares
Fabienne Louise Juvêncio dos Santos Amaral, Cristina Marques de Almeida Holanda, Maria Aparecida Bezerra Quirino, João Paulo da Silva Nascimento, Robson da Fonseca Neves, Kátia Suely Queiroz Silva Ribeiro, Simone Bezerra Alves,
Objetivou-se avaliar a acessibilidade de pessoas com deficiência e restrição de mobilidade permanente ao SUS em João Pessoa (PB). Trata-se de estudo descritivo de campo, composto por amostra aleatória de 523 pessoas com deficiência ou restrição permanente de mobilidade. A coleta de dados ocorreu no período de agosto de 2007 à dezembro de 2008 e consistiu de entrevistas domiciliares. As funções neuromusculoesqueléticas e relacionadas ao movimento foram as mais prejudicadas (52%), havendo maior acometimento ...
Tópico(s): Cerebral Palsy and Movement Disorders
2012 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva
Joana S. Amaral, Cristina G. Santos, Vítor S. Melo, Joana Costa, M. Beatriz P.P. Oliveira, Isabel Mafra,
Game meat Alheira (Alheira de caça) sausage is a traditional fermented product typical from the Northeast region of Portugal, having bread and meats (including game) as main ingredients. It is a particularly appreciated product by consumers that commands higher prices, especially in comparison with the common Alheira produced with pork and poultry meats. Following our previous work in which several mammalian game meat species were successfully identified in game meat Alheira sausages for authentication ...
Tópico(s): Food Supply Chain Traceability
2014 - Elsevier BV | Food Control
Patrícia Matias, Ana Azevedo, Ivo Laranjinha, David Navarro, Marco Mendes, Ana Carina Ferreira, Tiago Amaral, Cristina Jorge, Inês Aires, Célia Gil, Aníbal Ferreira,
<b><i>Background:</i></b> Hypomagnesaemia is a cardiovascular (CV) risk factor in the general population. The aim of this study was to evaluate the relationship between pre-dialysis magnesium (Mg) and CV risk markers, [including pulse pressure (PP), left ventricular mass index (LVMI) and vascular calcifications (VC)], and mortality in haemodialysis (HD) patients. <b><i>Methods:</i></b> We performed a 48-month prospective study in 206 patients under pre-dilution ...
Tópico(s): Trace Elements in Health
2014 - Karger Publishers | Blood Purification
Joana S. Amaral, Cristina G. Santos, Vítor S. Melo, M. Beatriz P.P. Oliveira, Isabel Mafra,
Alheira is a traditional meat product that is typical from the Northeast region of Portugal and much appreciated. It is a sort of sausage produced industrially or by small artisanal producers, having wheat bread and meats as main ingredients. Game meat Alheira (Alheira de caça) is considered one of the most attractive products since it should include different game meats. The aim of the present work was to identify the species of origin of meats added to game meat Alheira samples to verify their ...
Tópico(s): Food Supply Chain Traceability
2013 - Elsevier BV | Food Research International
Produção Nacional
Revisado por pares
Cı́ntia Alves, Rui Pereira, Lourdes Prieto, M. Aler, C.R.L. Amaral, Cristina Arévalo, Gabriela Berardi, F. Di Rocco, Mariela Caputo, Cristian Hernandez Carmona, Laura Catelli, Heloísa Afonso Costa, Pavla Coufalova, Sandra Furfuro, Óscar García, A. Gaviria, Ana Goios, Juan José Builes Gómez, Alexis Hernández, Eva del Carmen Betancor Hernández, L. Cunha-Miranda, David Parra, Susana Pedrosa, Maria João Porto, María Teresa Rebelo, Matteo Spirito, María del Carmen Villalobos Torres, António Amorim, Filipe Pereira,
DNA is a powerful tool available for forensic investigations requiring identification of species. However, it is necessary to develop and validate methods able to produce results in degraded and or low quality DNA samples with the high standards obligatory in forensic research. Here, we describe a voluntary collaborative exercise to test the recently developed Species Identification by Insertions/Deletions (SPInDel) method. The SPInDel kit allows the identification of species by the generation of ...
Tópico(s): Forensic and Genetic Research
2017 - Elsevier BV | Forensic Science International Genetics
Valentina Amaral, Cristina Romera‐Castillo, M. García-Delgado, A. Gómez‐Parra, Jesús M. Forja,
The Gulf of Cádiz, located in the Southern Iberian Atlantic Basin, connects the North Atlantic Ocean and the Mediterranean Sea and receives freshwater input from three main estuaries: Guadalquivir, Guadiana, and Tinto-Odiel. These estuaries differ in their hydrology, basin characteristic, and land use. One of them, Tinto-Odiel, is one of the most polluted estuaries in the world. However, little is known about the export of DOM from these estuaries to the Gulf of Cádiz. In this work, the estuaries ...
Tópico(s): Isotope Analysis in Ecology
2020 - Elsevier BV | Marine Chemistry
Valentina Amaral, Cristina Romera‐Castillo, Jesús M. Forja,
The Gulf of Cádiz (GoC) connects the Mediterranean Sea with the Atlantic Ocean through the Strait of Gibraltar. Particular hydrographic processes take place in the GoC, such as riverine discharges and surface circulation marked by wind-induced seasonal upwelling. Although physical processes have been widely studied, little is known about the biogeochemical processes that occur in the basin, especially those involving organic matter. Therefore, vertical and seasonal dynamics of dissolved organic carbon ( ...
Tópico(s): Oceanographic and Atmospheric Processes
2020 - Frontiers Media | Frontiers in Marine Science
Produção Nacional
Revisado por pares
Ana Carolina Gadotti, Marina de Castro Deus, João Paulo Telles, Rafael Wind, Marina Goes, Roberta Garcia Charello Ossoski, Alessandra Michalski de Padua, Lúcia de Noronha, Andréa Novais Moreno-Amaral, Cristina Pellegrino Baena, Felipe Francisco Tuon,
Innate and adaptive immune responses have been evaluated in infected patients with COVID-19. The severity of the disease has been supposed to be associated with some profile not reported with other bacterial and viral pneumonia. We proposed a study in patients with moderate to severe COVID-19 infection to evaluate the interleukin patterns and its role as prognosis factors.A prospective cohort with moderate and severe cases of COVID-19 infection from June to July 2020. Blood samples from patients ...
Tópico(s): Long-Term Effects of COVID-19
2020 - Elsevier BV | Virus Research
Vasko Kramer, René Fernández, Wencke Lehnert, Luis David Jiménez‐Franco, Cristian Soza‐Ried, Elisabeth Eppard, Matías Ceballos, Marian Meckel, Martina Benešová, Christoph A. Umbricht, Andreas Kluge, Roger Schibli, Konstantin Zhernosekov, Horacio Amaral, Cristina Müller,
Abstract Introduction PSMA-targeted radionuclide therapy with lutetium-177 has emerged as an effective treatment option for metastatic, castration-resistant prostate cancer (mCRPC). Recently, the concept of modifying PSMA radioligands with an albumin-binding entity was demonstrated as a promising measure to increase the tumor uptake in preclinical experiments. The aim of this study was to translate the concept to a clinical setting and evaluate the safety and dosimetry of [ 177 Lu]Lu-PSMA-ALB-56, a ...
Tópico(s): Mass Spectrometry Techniques and Applications
2020 - Springer Science+Business Media | European Journal of Nuclear Medicine and Molecular Imaging
Produção Nacional
Revisado por pares
Anna Flavia Ribeiro dos Santos Miggiolaro, Jarbas da Silva Motta, Caroline Busatta Vaz de Paula, Seigo Nagashima, Mineia Alessandra Scaranello Malaquias, Lucas Baena Carstens, Andréa Novais Moreno-Amaral, Cristina Pellegrino Baena, Lúcia de Noronha,
The COVID-19 pandemic is a worldwide threat, and information on physiopathological aspects of the disease is limited. Despite efforts in searching treatment options, a better understanding of the SARS-CoV-2 pathways can contribute to managing severe cases. In this study, we aim to describe pathological and immunopathogenic findings of two different cases, both in the high-risk group. Post-mortem lung biopsies were analyzed by traditional and immunohistochemical methods. Tissue expression of innate ...
Tópico(s): Inflammasome and immune disorders
2020 - Elsevier BV | Respiratory Medicine Case Reports
Valentina Amaral, Cristina Romera‐Castillo, Jesús M. Forja,
Abstract Seafloor structures related to the emission of different fluids, such as submarine mud volcanoes (MVs), have been recently reported to largely contribute with dissolved organic matter (DOM) into the oceans. Submarine MVs are common structures in the Gulf of Cádiz. However, little is known about the biogeochemical processes that occur in these peculiar environments, especially those involving DOM. Here, we report DOM characterization in the sediment pore water of three MVs of the Gulf of Cádiz. ...
Tópico(s): Ocean Acidification Effects and Responses
2021 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Ana Carolina Gadotti, A Lipiński, Franciane T. F. Vasconcellos, Luis Felipe Marqueze, Eduardo del Bosco Brunetti Cunha, Amanda Costa Campos, Camila F. Oliveira, Andréa NM. Amaral, Cristina Pellegrino Baena, João Paulo Telles, Felipe Francisco Tuon, Ricardo A. Pinho,
Several recent reviews have suggested a role of oxidative stress in the pathophysiology of COVID-19, but its interplay with disease severity has not been revealed yet. In the present study, we aimed to investigate the association between the severity of COVID‐19 and oxidative stress parameters. Clinical data of 77 patients with COVID‐19 admitted to the hospital were analyzed and divided into moderate (n = 44) and severe (n = 33) groups based on their clinical condition. Production of oxidant (hydrogen ...
Tópico(s): Vitamin C and Antioxidants Research
2021 - Elsevier BV | Free Radical Biology and Medicine
Cristina Amaral, Fabien Marc Trouille, Cristina Ferreira Almeida, Georgina Correia‐da‐Silva, Natércia Teixeira,
Breast cancer is the leading cause of cancer-related death in women worldwide. In the last years, cannabinoids have gained attention in the clinical setting and clinical trials with cannabinoid-based preparations are underway. However, contradictory anti-tumour properties have also been reported. Thus, the elucidation of the molecular mechanisms behind their anti-tumour efficacy is crucial to better understand its therapeutic potential. Considering this, our work aims to clarify the molecular mechanisms ...
Tópico(s): Diet, Metabolism, and Disease
2021 - Elsevier BV | The Journal of Steroid Biochemistry and Molecular Biology
Produção Nacional
Revisado por pares
João Alberto Arantes do Amaral, Cristina Toshie Motohashi Matsusaki,
In this article we discuss an action research experience that took place from 2002 to 2015. We analyze the inception and progress of several project-based learning-centered academic courses that were aimed at developing the project management skills of graduate and undergraduate students. The experience involved approximately 1800 students from two universities and 40 community partners. The students developed real-life projects on behalf of institutions and non-governmental organizations located ...
Tópico(s): Organizational Learning and Leadership
2016 - Taylor & Francis | Educational Action Research
Produção Nacional
Márcia Mendonça Carneiro, Ana Márcia de Miranda Cota, Maria Cristina Amaral, Moisa Lucia Pedrosa, Bruna O Martins, Marcelo H Furtado, Rívia Mara Lamaita, Márcia Cristina França Ferreira,
Breast cancer may affect young women who have not yet completed childbearing. Assisted reproductive technology (ART) provides alternatives for fertility preservation such as oocyte, embryo or ovarian tissue cryopreservation. We reviewed the published literature on fertility-preserving management in breast cancer, aiming at finding evidence to answer the following questions: (1) What are the fertility sparing options available?; (2) How do these women respond to IVF? and (3) Can pregnancy influence breast ...
Tópico(s): Ovarian function and disorders
2018 - Brazilian Society of Assisted Reproduction | JBRA
Produção Nacional
Revisado por pares
Denize Cristina de Oliveira, Frida Marina Fischer, Mariana Almeida do Amaral, María Cristina Triguero Veloz Teixeira, Celso Pereira de Sá,
O objetivo deste trabalho foi comparar as representações sociais de dois grupos de estudantes adolescentes, respectivamente dos períodos diurno e noturno, sobre o trabalho, a associação trabalho-estudo e o adolescente trabalhador. Participaram da pesquisa 724 estudantes do ensino médio público de São Paulo, de ambos os sexos, entre 14 e 18 anos, trabalhadores e não trabalhadores. A coleta de dados consistiu na técnica de evocações livres, que utilizou os termos indutores "trabalho", "trabalhar e estudar" ...
Tópico(s): Education and Work Dynamics
2005 - Springer Science+Business Media | Psicologia Reflexão e Crítica
Produção Nacional
Revisado por pares
Juliana Antico Lucchesi, Vanessa Renata Santos, Cristiane Mariote Amaral, Daiane Cristina Peruzzo, Poliana Mendes Duarte,
Background: The aim of this study was to evaluate clinically the treatment of gingival recession associated with non‐carious cervical lesions (NCCLs) by resin modified glass ionomer cement (RMGI) or microfilled resin composite (MRC) and coronally positioned flap (CPF) at 6 months following surgery. Methods: Fifty‐nine patients were assigned to one of three treatments: root exposure without NCCL treated with CPF (group 1); root exposure with NCCL treated with RMGI restoration plus CPF (group 2); or root ...
Tópico(s): Dental materials and restorations
2007 - Wiley | Journal of Periodontology
Helena Moreira, Anabela Amaral, María Cristina Canavarro,
A intimidade é um dos componentes principais de uma relação interpessoal próxima (Clark & Reis, 1988). Ainda que muitos investigadores se tenham dedicado ao estudo deste constructo, não existe ainda uma definição consensual. Para Schaefer e Olson (1981), a intimidade é um processo e uma experiência, que resulta da revelação de assuntos íntimos e da partilha de experiências. Partindo de uma conceptualização multidimensional, construíram o Personal Assessment of Intimacy in Relationships Scale (PAIR), ...
Tópico(s): Death Anxiety and Social Exclusion
2009 - Coimbra University Press | Psychologica
Produção Nacional
Revisado por pares
Carla Polo Fonseca, Mariane A. Bellei, Fábio Augusto do Amaral, Sheila Cristina Canobre, S. Neves,
Films of doped LiMxMn2−xO4 (M = Cs, Al and Bi) were deposited on Indium Tin Oxide (ITO) substrate using the Pechini method. X-ray diffraction (XRD) and differential thermal analysis (DTA) were used for structural characterization of the oxides. Their morphology was studied by scanning electron microscope (SEM) and their electrochemical properties by cyclic voltammetry, charge/discharge tests and electrochemical impedance spectroscopy in a 1.0 mol L−1 LiClO4/EC:PC 1:1 (v/v) electrolyte. A single-phase spinel ...
Tópico(s): Transition Metal Oxide Nanomaterials
2009 - Elsevier BV | Energy Conversion and Management
Cristina Amaral, Eugénia Gallardo, Rute De Sousa Rodrigues, Rosário Pinto‐Leite, Dulce Quelhas, Cândida T. Tomaz, Maria Luı́s Cardoso,
Cholesterol and its precursors, namely 7-dehydrocholesterol, desmosterol and lathosterol are important biochemical markers of cholesterol biosynthesis, and their quantification in body fluids is useful for the diagnosis of cholesterol biosynthesis pathway disorders. A rapid and sensitive gas chromatographic–mass spectrometric method was developed and validated for quantitative analysis of five sterols (cholesterol, 7-dehydrocholesterol, desmosterol, lathosterol and sitosterol) in amniotic fluid. ...
Tópico(s): Hormonal and reproductive studies
2010 - Elsevier BV | Journal of Chromatography B
Produção Nacional
Revisado por pares
Kátia Maria Gomes Machado, Luciana Cristina Amaral Compart, Rúbio O. Morais, Luiz Henrique Rosa, M.H.Silla Santos,
The potential of Trametes villosa and Pycnoporus sanguineus to decolorize reactive textile dyes used for cotton manufacturing in the State of Minas Gerais, Brazil, was evaluated. Growth and decolorization halos were determined on malt extract agar containing 0.002g L-1 of the dye. T. villosa decolorized all 28 of the tested dyes while P. sanguineus decolorized only 9. The effect of culture conditions (shaking and dye and nitrogen concentration) on the degradation of Drimaren Brilliant Blue dye was ...
Tópico(s): Chromium effects and bioremediation
2006 - Springer Nature | Brazilian Journal of Microbiology
Ariadna Janice Drumond Morais, Paulo Maia, Ana Azevedo, Cristina Amaral, Juliana Petri Tavares,
Anaesthesiology is considered a stressful occupation. Our purpose was to assess stress and burnout among Portuguese anaesthesiologists.A cross-sectional survey based on an anonymous questionnaire was sent to all Portuguese anaesthesiologists registered by the Portuguese Medical Association. Data on patient characteristics and professional variables, perceived stress (Perceived Stress Scale), the subscale of work satisfaction of the Pressure Management Indicator scale, burnout (Maslach Burnout Inventory) ...
Tópico(s): Workplace Health and Well-being
2006 - Lippincott Williams & Wilkins | European Journal of Anaesthesiology
Cristina Amaral, Margarida Borges, Soraia Melo, E. J. Tavares da Silva, Georgina Correia‐da‐Silva, Natércia Teixeira,
Aromatase inhibitors (AIs), which block the conversion of androgens to estrogens, are used for hormone-dependent breast cancer treatment. Exemestane, a steroidal that belongs to the third-generation of AIs, is a mechanism-based inhibitor that binds covalently and irreversibly, inactivating and destabilizing aromatase. Since the biological effects of exemestane in breast cancer cells are not totally understood, its effects on cell viability, cell proliferation and mechanisms of cell death were studied ...
Tópico(s): Estrogen and related hormone effects
2012 - Public Library of Science | PLoS ONE
Carla Varela, E. J. Tavares da Silva, Cristina Amaral, Georgina Correia‐da‐Silva, Teresa Baptista, Stefano Alcaro, Giosuè Costa, Rui A. Carvalho, Natércia Teixeira, Fernanda M.F. Roleira,
A- and D-ring androstenedione derivatives were synthesized and tested for their abilities to inhibit aromatase. In one series, C-3 hydroxyl derivatives were studied leading to a very active compound, when the C-3 hydroxyl group assumes 3β stereochemistry (1, IC(50) = 0.18 μM). In a second series, the influence of double bonds or epoxide functions in different positions along the A-ring was studied. Among epoxides, the 3,4-epoxide 15 showed the best activity (IC(50) = 0.145 μM) revealing the possibility ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2012 - American Chemical Society | Journal of Medicinal Chemistry
Produção Nacional
Revisado por pares
César Dalmolin Bergoli, Marina Amaral, Letícia Cristina Cidreira Boaro, Roberto Ruggiero Braga, Luiz Felipe Valandro,
To evaluate the effect of mechanical cycling and cementation strategies on the push-out bond strength between fiber posts and root dentin and the polymerization stresses produced using three resin cements.Eighty bovine mandibular teeth were sectioned to a length of 16 mm, prepared to 12 mm, and embedded in self-curing acrylic resin. The specimens were then distributed into 8 groups (n = 10): Gr1 - Scotchbond Multi Purpose + RelyX ARC; Gr2 - Scotchbond Multi Purpose + RelyX ARC + mechanical cycling; Gr3 - AdheSE + ...
Tópico(s): Concrete and Cement Materials Research
2012 - Quintessence Publishing Company | Journal of adhesive dentistry/The journal of adhesive dentistry
Produção Nacional
Revisado por pares
Patrícia Barreto Costa Nico, Fernanda de Paris, Elsa Regina Vinadé, Olavo B. Amaral, Isabel Cristina Rockenbach, Bruno Lobão‐Soares, Ricardo Guarnieri, Lauro Wichert‐Ana, Fabrício Calvo, Roger Walz, Iván Izquierdo, Américo Ceiki Sakamoto, Helena Brentani, Vilma R. Martins, Marino Muxfeldt Bianchin,
Although many studies have investigated the function of cellular prion protein (PrPc), its physiologic role remains elusive. PrPc null mice have been reported to develop normally and to show normal performance in most behavioural tests. In the present study we investigated whether this also holds true after episodes of acute stress. PrPc gene ablated (Prnp0/0) and wild-type mice were subjected to restraint stress, electric foot shock, or swimming and compared with non-stressed animals. Immediately ...
Tópico(s): Prion Diseases and Protein Misfolding
2005 - Elsevier BV | Behavioural Brain Research
Jorge Polónia, Cristina Amaral, Susana Bertoquini, Luís Martins,
To evaluate whether hypertensive patients with attenuation of nighttime blood pressure (BP) fall exhibit a delay of the recovery of heart rate (HR) after exercise as an index of a general decrease in the vagal tone.Mild-moderate hypertensive patients (n = 219, age 55 +/- 3, 77% men) underwent a maximal exercise test (Bruce > 85% heart rate limited) in whom we calculated the recovery of HR as the percent decrease of HR from peak to 1 min after stopping exercise (%HR fall-1 min), a 24-h ambulatory BP monitoring, ...
Tópico(s): Blood Pressure and Hypertension Studies
2005 - Elsevier BV | International Journal of Cardiology
Jorge J. Pol nia, Guilherme Gama, Jos A. Silva, Cristina Amaral, Luís Martins, Susana Bertoquini,
In subjects with white-coat hypertension (WCH) it is unclear how ambulatory blood pressure (ABPM) progresses over time and whether they exhibit an increased cardiovascular risk.We prospectively evaluated the transition of clinic and ABPM values in 39 clinic and ABPM normotensive subjects (NT) (clinic BP<140/90 mmHg and awake BP 140/90, awake ABP<130/85 mmHg) with no other major cardiovascular risk factors. Ambulatory blood pressure was evaluated at baseline and on at least two further occasions during ...
Tópico(s): Sodium Intake and Health
2005 - Lippincott Williams & Wilkins | Blood Pressure Monitoring