Alan Owens, J. J. R. Trethowan, Charles Raw, Richard Buckle, Elizabeth Nicholas, Nicholas Carroll Diplomatic Correspondent, Harold Hobson, John Hibbs, Drusilla Beyfus, Anthony Vice Editor, Roger Nuttall, V S Bowling, J D Norle, Wilson, Cal McCrystal, George V Burkholder, Elizabeth Good, Henry Brandon, John Russell, Jack Cox, Geoffrey Nicholson, Rev Dr Leslie D Weatherhead, Ivor Tilney, Derek Jewell, A. C., Elizabeth Woolley, Patrick Campbell, Vivian Jenkins, Julian Critchley, Tom Margerison, Ian Coulter, Peter Willett, Alan Moorehead, R S Borner Secretary, Michael Hamlyn, Cyril Connolly, James Tucker, Anthony Vice, Raymond Mortimer, (Mrs) M Done, Mr Callaghan, Nicholas Evans, John Barry, Arthur Seldon Editorial Director, Sydney Silverman, Pierre Vincent, Bryan Silcock, Sidney Marks, Michael Limb, Roger Mortimer, Antony Turner, Ernestine Carter, Desmond Shawe-Taylor, David Drew, A R C Southby, Stephen Aris, Ronald Legge, R. C. Robertson-Glasgow, Lanning Roper, Dilys Powell, Brigid Keenan, Richard Hughes, William Rees-Mogg, David Wiggins, Salmon Spray, Robert Carrier, Felix Aprahamian, Margaret Costa, Ian Coulter Industrial Correspondent, Henry Longhurst, Yvonne Lubbock, Christopher Ricks, Gerald Holden, Brian Glanville, Keith Richardson, Benny Green, Peter Dunn, Dave Phillips, Michael Green, C. H. O'd. Alexander, T. Verschoyle, Maurice Wiggin, Mr. A. Chester Beatty, Anthony Cowdy, (Miss) Anna Drake, Susan Cooper, Kenneth Konstam, Hugh Trevor-Roper, Nicholas Tomalin,
... Greek Line No Title Royal Mail Lines Reina Cristina Multiple Display Advertising Items Holiday Villas Ltd. Olympic ... The Loved Ones Senior Service The Lovers Porto Branco Sheaffer Bridge Chess Problem No. 349 Mephisto Crossword ...
1964 - Gale Group | Sunday Times HA GDA
Cristina Branco‐Price, Colin E. Evans, Randall S. Johnson,
// Cristina Branco-Price 1 , Colin E. Evans 1 , and Randall S. Johnson 1 1 Department of Physiology, Development ...
Tópico(s): Adrenal and Paraganglionic Tumors
2013 - Impact Journals LLC | Oncotarget
Marco Gomes da Silva, M. Manuela A. Pereira, Ricardo Franco, Madalena Dionı́sio, Luı́sa M. Ferreira, Paula S. Branco, Cristina Costa, Ana Lourenço, Alice S. Pereira, Paulina Mata, João Sotomayor, João Carlos Lima, Márcia Vilarigues, A. Jorge Parola, César A. T. Laia, Isabel B. Coutinho, Luı́s C. Branco, Cláudia C. L. Pereira, Artur J. Moro, Sandra Gago, Nuno Basílio, M. Manuel B. Marques,
M. Gomes da SilvaM.M. PereiraR. FrancoM. DionisioL.M. FerreiraP. BrancoC. CostaA. LourençoA.S. PereiraP. MataJ. SotomayorJ.C. LimaM. VilariguesA.J. ParolaC.A.T. LaiaI. CoutinhoL. BrancoC. PereiraA. MoroS. GagoN. BasílioM.M. Marques
Tópico(s): Science and Science Education
2017 - International Academy of Technology, Education and Development | EDULEARN proceedings
Ricardo Ferraz, Luı́s C. Branco, Cristina Prudêncio, João Paulo Noronha, Željko Petrovski,
Abstract Review: about 70 refs.
Tópico(s): Chemical Synthesis and Reactions
2011 - Wiley | ChemInform
Fernando Maltêz, Manuela Doroana, Teresa Branco, Cristina Valente,
Purpose of review To discuss new antiretroviral agents (ARVs) and alternative ARV treatment strategies that are currently being evaluated, and to provide an overview of the most recent advances in HIV vaccine development. Recent findings There is a continuous need for improvements in ARV therapy (ART) and several new ARVs are currently undergoing clinical investigation, including the non-nucleoside reverse transcriptase inhibitor rilpivirine, the integrase inhibitor elvitegravir, the chemokine receptor ...
Tópico(s): HIV/AIDS Research and Interventions
2011 - Lippincott Williams & Wilkins | Current Opinion in HIV and AIDS
Ricardo Ferraz, Luı́s C. Branco, Cristina Prudêncio, João Paulo Noronha, Željko Petrovski,
Abstract Ionic liquids (ILs) are ionic compounds that possess a melting temperature below 100 °C. Their physical and chemical properties are attractive for various applications. Several organic materials that are now classified as ionic liquids were described as far back as the mid‐19th century. The search for new and different ILs has led to the progressive development and application of three generations of ILs: 1) The focus of the first generation was mainly on their unique intrinsic physical and ...
Tópico(s): Electrochemical sensors and biosensors
2011 - Wiley | ChemMedChem
Grant Mair, Rüdiger von Kummer, Zoë Morris, Anders von Heijne, Nick Bradey, Lesley Cala, André Peeters, Andrew Farrall, Alessandro Adami, Gillian Potter, Geoff Cohen, Peter Sandercock, Richard I. Lindley, Joanna M. Wardlaw, Peter Sandercock, Richard I. Lindley, Joanna M. Wardlaw, Colin Baigent, David Chadwick, Pippa Tyrrell, Gordon Lowe, Martin Dennis, Geoff Cohen, Karen Innes, Heather Goodare, Richard I. Lindley, Graeme J. Hankey, Karl Matz, Michael Brainin, Gord Gubitz, Stephen Phillips, Stefano Ricci, Antonio Araúz, Eivind Berge, Karsten Bruins Slot, Anna Członkowska, Adam Kobayashi, Manuel Correia, Phillippe Lyrer, Stefan T. Engelter, Veronica Murray, Andreas Terént, Bo Norrving, Per Wester, G.S. Venables, Joanna M. Wardlaw, Andrew Farrall, Zoë Morris, Rüdiger von Kummer, Lesley Cala, Anders von Heijne, Alessandro Adami, André Peeters, Gillian Potter, Nick Bradey, Joanna M. Wardlaw, Rüdiger von Kummer, Andrew Farrall, Robin Sellar, Alessandro Adami, Phil White, Andrew M. Demchuk, Matthew Adams, Grant Mair, Bernard Yan, G.S. Venables, C Blank, Helen Bowler, Cara Doyle, Keith Endean, K. Harkness, Edward F. Parker, Marc Randall, Christine Roffe, Naveed Ahmad, Anand Arora, Susan V. Brammer, J Chembala, B. Davies, Sarah J. Ellis, Richard H. Epstein, K. Finney, Chris Jackson, Changez Jadun, Ruth Kinston, Holly Maguire, I Memon, Indira Natarajan, Michael Poulson, R. Sanyal, Sheila Sills, ANNA E. M. VREEBURG, Elizabeth Ward, Peter Sandercock, Rustam Al‐Shahi Salman, Richard Davenport, Martin Dennis, Peter J. Hand, Simon P. Hart, Ingrid Kane, Sarah Keir, Mary Joan MacLeod, L McKinlay, Hazel Milligan, E SANDEMAN, Jennifer Stone, Cathie Sudlow, Peter R. Taylor, Joanna M. Wardlaw, C Warlow, William Whiteley, A. Olufemi Williams, M. Brown, B.S. Athwal, Vanessa Bassan, Neelima Bhupathiraju, John V. Bowler, Charles Davie, David Doig, Renuka Erande, Stephen Gilbert, Lionel Ginsberg, Nan Greenwood, Simone M. Gregoire, Nicola Harding, Nicholas Losseff, Robert Luder, Nathalie Passeron, Richard Perry, Philip Rayson, Robert Simister, Simon Stone, David J. Werring, James Barrett, H Aitken, Sarah Cherian, Ryan L. Davis, Susan Downham, L Godd, V. L. Gott, David José, Victoria Little, David Lowe, L Luxford, Matthew T. McGrory, Paula Owings, N Price, John Richards, Graeme Sangster, Julian Sherlock, Susan Vargese, Ian Wakefield, Pauline Weir, Paul Guyler, T Attygale, Susan M. Chandler, Lucy Coward, S Feasey, C Khuoge, Thayalini Loganathan, Sascha E. Martin, Anne Sibley O'Brien, D Sinha, Vanessa R. Thompson, Sharon Tysoe, Richard Walsh, Kerstin Metcalf, Jeffrey I. Cochius, Ryan P. Fulcher, Nisal Gange, Catherine Green, Jacqui Jagger, M Lee, Phyo Kyaw Myint, John F. Potter, Garth Ravenhill, Stephanie Shields, Naval Shinh, Tom Staunton, Eleanor Thomas, Wendy A. Woodward, P. H. L. WORTH, N. Wyatt, W Sunman, Philip M. Bath, Peter H. Berman, Judith Clarke, Catherine Gaynor, Fiona Hammonds, Rowan Harwood, Kate M. Mitchell, Soumyabrata Munshi, Sarah Pacey, Ashit Shetty, Nikola Sprigg, H Stear, G. Mani Subramanian, Andrew K. Wills, Anthony Rudd, Heinrich J. Audebert, Ajay Bhalla, Jonathan Birns, Rasheda A. Chowdhury, Gillian Cluckie, Ian G. Davies, Charlotte Gibbs, Patrick Holmes, Nicola J. Mitchell, Francesca Schiavone, Eleanor White, Meredith T. Yeung, A. Mehrzad, Vidyagauri P. Baliga, Eli M. Brown, Lewis Burnside, Bernard Esisi, Jennifer L. Kent, Orr P, David Stead, Emma Wayman, R Durairaj, C Cullen, Rohit Kumar, H Martı́n, Dermot T. McDowell, Alka Sharma, Victoria Sutton, Robert M. White, Thomas A. Hughes, Khalid Ali, J. Anderson, Katherine Baker, K Bethune, K Bethune, M Booth, M. Cossburn, Sophie Halpin, M D Hourihan, E. Neil G. Marsh, K. J. Peall, Rebecca Powell, Hamsaraj Shetty, M. Wardle, Michelle A. Williams, K Muhiddin, Jessica Beavan, M Clarke, R Donneley, Simon Elliott, Peter Fox, Peter H. Gorman, Margaret Harper, M Mangoyana, I Memon, Lisa Mills, L Wright, Liz Warburton, Jean‐Claude Baron, Peter Barry, Diana J. Day, Teresa Harold, Pilar Matía‐Martín, Jennifer Mitchell, Eoin O’Brien, J Rycarte, M Turnham, Geoffrey Cloud, L Y Lois Choy, Ben Clarke, C. J. Griffin, Omid Halse, Ifan Jones, Fiona Kennedy, Uzma Khan, Russell E. Lewis, Alison Loosemore, Caroline Lovelock, Markus Holtmannspötter, B. Moynihan, J. N. O'Reilly, Paul Olowoyo, Anthony Pereira, Martin Punter, Preston B. Rich, Debbie Rolfe, Francesca Schiavone, Martin James, James Bell, A. Bowring, Lucy Boxall, Julie Cageao, H. Eastwood, Salim Elyas, Fiona Hall, S. Harries, Anthony Hemsley,
Objective: To investigate whether the location and extent of the CT hyperdense artery sign (HAS) at presentation affects response to IV alteplase in the randomized controlled Third International Stroke Trial (IST-3). Methods: All prerandomization and follow-up (24–48 hours) CT brain scans in IST-3 were assessed for HAS presence, location, and extent by masked raters. We assessed whether HAS grew, persisted, shrank, or disappeared at follow-up, the association with 6-month functional outcome, and effect of alteplase. ...
Lippincott Williams & Wilkins
Luís Gabriel A. Barboza, Luís R. Vieira, Vasco Branco, Cristina Carvalho, Lúcia Guilhermino,
The presence of microplastics and several other pollutants in the marine environment is of growing concern. However, the knowledge on the toxicity of mixtures containing microplastics and other contaminants to marine species is still scarce. The main goals of this study were to investigate the oxidative stress and lipid oxidative damage potentially induced by 96 h of exposure to mercury (0.010 and 0.016 mg/L), microplastics (0.26 and 0.69 mg/L), and mixtures of the two substances (same concentrations, ...
Tópico(s): Nanoparticles: synthesis and applications
2018 - Nature Portfolio | Scientific Reports
Vasco Branco, Cristina Carvalho,
Mercury interaction with selenium in vivo has been recognized for >50 years. Several researchers attempted to use selenium to mitigate the detrimental effects of mercurial compounds but the results were controversial. Selenium pools in living organisms are quite low and the high affinity of mercury to bind selenols pointed out selenoproteins as possible targets of toxicity. Such was the case of the selenoenzyme thioredoxin reductase (TrxR) which is an integrant part of the thioredoxin system. Given ...
Tópico(s): Mercury impact and mitigation studies
2018 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - General Subjects
Filipa Júlio, Maria José Ribeiro, Miguel Patrício, Alexandre Malhão, Fábio O. Pedrosa, Hélio Gonçalves, Marco Simões, Marieke van Asselen, Mário R. Simões, Miguel Castelo‐Branco, Cristina Januário,
Introduction - Impairments in executive functions are common in neurogenetic disorders such as Huntington's disease (HD) and are thought to significantly influence the patient's functional status. Reliable tools with higher ecological validity that can assess and predict the impact of executive dysfunction in daily-life performance are needed. This study aimed to develop and validate a novel non-immersive virtual reality task ("EcoKitchen") created with the purpose of capturing cognitive and functional ...
Tópico(s): Neurological disorders and treatments
2019 - Frontiers Media | Frontiers in Psychology
Carla Lopes, Ildete L. Ferreira, Carina Maranga, M Beatriz, Sandra I. Mota, José Sereno, João Castelhano, Antero Abrunhosa, Francisco P. M. Oliveira, Maura De Rosa, Michael R. Hayden, Mário Laço, Cristina Januário, Miguel Castelo‐Branco, A. Cristina Rego,
Deficits in mitochondrial function and redox deregulation have been attributed to Huntington's disease (HD), a genetic neurodegenerative disorder largely affecting the striatum. However, whether these changes occur in early stages of the disease and can be detected in vivo is still unclear. In the present study, we analysed changes in mitochondrial function and production of reactive oxygen species (ROS) at early stages and with disease progression. Studies were performed in vivo in human brain by ...
Tópico(s): Neurological disorders and treatments
2022 - Elsevier BV | Redox Biology
Produção Nacional
Revisado por pares
Marco Antônio Alves Carneiro, Cristina Branco, C.E. Braga, Emmanuel Duarte Almada, Marina Batista Morais Costa, Valéria Cid Maia, Geraldo Wilson Fernandes,
Despite the speciose fauna of gall-inducing insects in the Neotropical region, little is known about their taxonomy. On the other hand, gall morphotypes associated with host species have been extensively used as a surrogate of the inducer species worldwide. This study reviewed the described gall midges and their galls to test the generalization on the use of gall morphotypes as surrogates of gall midge species in the Brazilian fauna. We compiled taxonomic and biological data for 196 gall midge species ...
Tópico(s): Research on scale insects
2009 - Entomological Society of Brazil | Revista Brasileira de Entomologia
Produção Nacional
Revisado por pares
Maria Regina Sposto, Maria José Soares Mendes‐Giannini, Rosângela Aparecida Moraes, Fernanda Cristina Branco, Crispian Scully,
Paracoccidioidomycosis (South American blastomycosis) is a systemic mycosis which can he associated with oral lesions. This study on a group of 14 patients showed oral lesions mainly on the gingival or alveolar mucosa with pulmonary involvement detectable on chest radiography in most. Microscopic detection of the fungus on a direct smear showed positive results in all 14 patients. Serological investigations including immunodiffusion, counterimmunoelectrophoresis and immunoblot were also positive ...
Tópico(s): Infectious Diseases and Mycology
1994 - Wiley | Journal of Oral Pathology and Medicine
Paola Cristina Branco, Leandro Nogueira Pressinotti, Jõao Carlos Shimada Borges, Renata Stecca Iunes, José Roberto Kfoury, Marcos Oliveira da Silva, Marcelo González‐Aravena, Marinilce Fagundes dos Santos, Lloyd S. Peck, Edwin L. Cooper, José Roberto Machado Cunha da Silva,
Tópico(s): Marine Bivalve and Aquaculture Studies
2011 - Springer Science+Business Media | Polar Biology
Cláudia Nunes dos Santos, Margarida Gaspar, A. S. Caeiro, Cristina Branco‐Price, Artur R. Teixeira, Ricardo B. Ferreira,
In animal cells, arsenite has been reported to cause sulfhydryl depletion, generate reactive oxygen species and increase the level of large ubiquitin–protein conjugates. Plant viability tests and DNA laddering experiments have shown that Lemna minor remains viable after exposure to 50 μM NaAsO 2 for periods of at least 6 h. However, protein metabolism is affected in two major ways: the synthesis of an array of stress proteins, which confer thermotolerance; and an increase in the amount of large ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2006 - Oxford University Press | Plant and Cell Physiology
Colin E. Evans, Cristina Branco‐Price, Randall S. Johnson,
Tumour growth at primary or secondary extravasation sites leads to localised regions of reduced oxygen tension (hypoxia) in cells both within and surrounding the tumour. Although the angiogenic response of the tumour cell to hypoxia has been widely examined, the effect of hypoxia on other cell types within the tumour microenvironment is less clear. The endothelium is highly responsive to local hypoxia and regulates tumour cell dissemination and ultimately metastatic success through differential regulation ...
Tópico(s): Adrenal and Paraganglionic Tumors
2012 - Springer Science+Business Media | International Journal of Hematology
Jung‐whan Kim, Colin E. Evans, Alexander Weidemann, Norihiko Takeda, Yun Sok Lee, Christian Stockmann, Cristina Branco‐Price, Filip Brandberg, Gustavo Leone, Michael C. Ostrowski, Randall S. Johnson,
Solid tumors consist of malignant cells and associated stromal components, including fibroblastic cells that contribute to tumor growth and progression. Although tumor fibrosis and aberrant vascularization contribute to the hypoxia often found in advanced tumors, the contribution of hypoxic signaling within tumor-associated fibroblasts to tumorigenesis remains unknown. In this study, we used a fibroblast-specific promoter to create mice in which key hypoxia regulatory genes, including VHL, HIF-1α, ...
Tópico(s): High Altitude and Hypoxia
2012 - American Association for Cancer Research | Cancer Research
Cristina Branco‐Price, Na Zhang, Moritz Schnelle, Colin E. Evans, Dörthe M. Katschinski, Debbie Liao, Lesley G. Ellies, Randall S. Johnson,
The hypoxia inducible transcription factors (HIFs) control many mediators of vascular response, including both angiogenic factors and small molecules such as nitric oxide (NO). In studying how endothelial HIF response itself affects metastasis, we found that loss of HIF-1α in endothelial cells reduces NO synthesis, retards tumor cell migration through endothelial layers, and restricts tumor cell metastasis, and that loss of HIF-2α has in each case the opposite effect. This results from differential ...
Tópico(s): Nitric Oxide and Endothelin Effects
2012 - Cell Press | Cancer Cell
CRISTINA BRANCO-PRICE, RIKI KAWAGUCHI, Ricardo B. Ferreira, Julia Bailey‐Serres,
Tópico(s): Photosynthetic Processes and Mechanisms
2005 - Oxford University Press | Annals of Botany
Cristina Branco‐Price, Riki Kawaguchi, Ricardo B. Ferreira, Julia Bailey‐Serres,
• Background and Aims DNA microarrays allow comprehensive estimation of total cellular mRNA levels but are also amenable to studies of other mRNA populations, such as mRNAs in translation complexes (polysomes). The aim of this study was to evaluate the role of translational regulation in response to oxygen deprivation (hypoxia).
Tópico(s): Lipid metabolism and biosynthesis
2005 - Oxford University Press | Annals of Botany
Tom Ashmore, Bernadette Fernandez, Cristina Branco‐Price, James A. West, Andrew S. Cowburn, Lisa C. Heather, Julian L. Griffin, Randall S. Johnson, Martin Feelisch, Andrew J. Murray,
Key points Exposure to environmental hypoxia, at high altitude or in a chamber, impairs cardiac energetics and alters mitochondrial function. Inorganic nitrate, a ubiquitous dietary constituent, improves mitochondrial efficiency, lowering the oxygen cost of exercise, whilst elevated circulating nitrogen oxide levels in high‐altitude natives enhances blood flow. Here we report that dietary nitrate supplementation prevents hypoxia‐induced changes in cardiac mitochondrial function and energetics, whilst ...
Tópico(s): High Altitude and Hypoxia
2014 - Wiley | The Journal of Physiology
Tom Ashmore, Bernadette Fernandez, Colin E. Evans, Yun Huang, Cristina Branco‐Price, Julian L. Griffin, Randall S. Johnson, Martin Feelisch, Andrew J. Murray,
In mammals, hypoxia-triggered erythropoietin release increases red blood cell mass to meet tissue oxygen demands. Using male Wistar rats, we unmask a previously unrecognized regulatory pathway of erythropoiesis involving suppressor control by the NO metabolite and ubiquitous dietary component nitrate. We find that circulating hemoglobin levels are modulated by nitrate at concentrations achievable by dietary intervention under normoxic and hypoxic conditions; a moderate dose of nitrate administered ...
Tópico(s): Erythropoietin and Anemia Treatment
2014 - Wiley | The FASEB Journal
Produção Nacional
Revisado por pares
Paola Cristina Branco, Jõao Carlos Shimada Borges, Marinilce Fagundes dos Santos, Bernard Ernesto Jensch, José Roberto Machado Cunha da Silva,
Ocean temperatures are rising throughout the world, making it necessary to evaluate the impact of these temperature changes on sea urchins, which are well-known bioindicators. This study evaluated the effect of an increase in temperature on the immune response of the subtidal Lytechinus variegatus and the intertidal Echinometra lucunter sea urchins. Both species were exposed to 20 (control), 25 and 30 °C temperatures for 24 h, 2, 7 and 14 days. Counting of coelomocytes and assays on the phagocytic ...
Tópico(s): Coral and Marine Ecosystems Studies
2013 - Elsevier BV | Marine Environmental Research
Produção Nacional
Revisado por pares
Fábio Bucaretchi, Eduardo Mello De Capitani, Maíra Migliari Branco, Luciane Cristina Rodrigues Fernandes, Stephen Hyslop,
Context. Rattlesnake bites in Brazil are generally caused by adult individuals, with most of the envenomed patients showing systemic manifestations that include varying degrees of neurotoxicity (acute myasthenia), rhabdomyolysis and coagulopathy, with only mild or no local manifestations. We report a case of envenoming by a juvenile South American rattlesnake (Crotalus durissus terrificus) that involved coagulopathy as the main systemic manifestation. Case details. A 19-year-old male was admitted ...
Tópico(s): Marine Invertebrate Physiology and Ecology
2013 - Taylor & Francis | Clinical Toxicology
Produção Nacional
Marcel Serra Coelho, Marco Antônio Alves Carneiro, Cristina Branco, Rafael Augusto Xavier Borges, Geraldo Wilson Fernandes,
Gall-inducing insects are very specious in vegetations of southeastern Brazil. Our goal was describe the gall richness by characterizing their external forms and their patterns of occurrence on host plants. Samples were collected from Campos de Altitude at four regions of the Mantiqueira Range: 1) Parque Estadual da Serra do Brigadeiro, 2) Parque Nacional do Caparaó, 3) Parque Estadual do Ibitipoca, 4) Parque Nacional do Itatiaia. We found 93 gall species within 13 families, 30 genera and 50 host ...
Tópico(s): Lepidoptera: Biology and Taxonomy
2013 - Fundação de Amparo à Pesquisa do Estado de SP | Biota Neopropica/Biota Neotropica
Carolina Alves, Cristina Branco, Celso Cunha,
The hepatitis delta virus (HDV) is distributed worldwide and related to the most severe form of viral hepatitis. HDV is a satellite RNA virus dependent on hepatitis B surface antigens to assemble its envelope and thus form new virions and propagate infection. HDV has a small 1.7 Kb genome making it the smallest known human virus. This deceivingly simple virus has unique biological features and many aspects of its life cycle remain elusive. The present review endeavors to gather the available information ...
Tópico(s): Hepatitis Viruses Studies and Epidemiology
2013 - Hindawi Publishing Corporation | Advances in Virology
Tom Ashmore, Lee D. Roberts, Andrea J. Morash, Aleksandra Kotwica, John R. Finnerty, James A. West, Steven A. Murfitt, Bernadette Fernandez, Cristina Branco, Andrew S. Cowburn, Kieran Clarke, Randall S. Johnson, Martin Feelisch, Julian L. Griffin, Andrew J. Murray,
Insulin sensitivity in skeletal muscle is associated with metabolic flexibility, including a high capacity to increase fatty acid (FA) oxidation in response to increased lipid supply. Lipid overload, however, can result in incomplete FA oxidation and accumulation of potentially harmful intermediates where mitochondrial tricarboxylic acid cycle capacity cannot keep pace with rates of β-oxidation. Enhancement of muscle FA oxidation in combination with mitochondrial biogenesis is therefore emerging ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2015 - BioMed Central | BMC Biology
Colin E. Evans, Pär‐Ola Bendahl, Mattias Belting, Cristina Branco, Randall S. Johnson,
Key Points Cell-specific hypoxia-inducible factor 1 can regulate cancer-associated hypercoagulation and thrombus formation.
Tópico(s): Cardiac tumors and thrombi
2015 - Elsevier BV | Blood
Produção Nacional
Revisado por pares
Gabriel Costa de Carvalho, Rosana Domingues, Maurício Lacerda Nogueira, Ana F. Branco, Kelly Cristina Gomes Manfrere, Naiura Vieira Pereira, Valéria Aoki, Mírian Nacagami Sotto, Crislaine Aparecida da Silva, Maria Notomi Sato,
Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. The inflammatory status of LP may be related to S100A8 (myeloid-related protein 8; MRP8) activation of cytotoxic cells. The aims of this study were to evaluate S100A8 expression in skin lesions and the in vitro effects of S100A8 on CD8+ T cells and natural killer (NK) cells in LP. Increased levels of S100A8/S100A9 were detected in the skin lesions as well as in the sera of subjects with LP. S100A8 expression induced an increased cytotoxic ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2015 - Soc for Publication of Acta Dermato-Venereologica | Acta Dermato Venereologica
Hideki Yamamoto, Helene Rundqvist, Cristina Branco, Randall S. Johnson,
Vascular endothelial growth factor A (VEGF) is involved in all the essential biology of endothelial cells, from proliferation to vessel function, by mediating intercellular interactions and monolayer integrity. It is expressed as three major alternative spliced variants. In mice, these are VEGF120, VEGF164, and VEGF188, each with different affinities for extracellular matrices and cell surfaces, depending on the inclusion of heparin-binding sites, encoded by exons 6 and 7. To determine the role of ...
Tópico(s): Nitric Oxide and Endothelin Effects
2016 - Frontiers Media | Frontiers in Cell and Developmental Biology