Alan Owens, J. J. R. Trethowan, Charles Raw, Richard Buckle, Elizabeth Nicholas, Nicholas Carroll Diplomatic Correspondent, Harold Hobson, John Hibbs, Drusilla Beyfus, Anthony Vice Editor, Roger Nuttall, V S Bowling, J D Norle, Wilson, Cal McCrystal, George V Burkholder, Elizabeth Good, Henry Brandon, John Russell, Jack Cox, Geoffrey Nicholson, Rev Dr Leslie D Weatherhead, Ivor Tilney, Derek Jewell, A. C., Elizabeth Woolley, Patrick Campbell, Vivian Jenkins, Julian Critchley, Tom Margerison, Ian Coulter, Peter Willett, Alan Moorehead, R S Borner Secretary, Michael Hamlyn, Cyril Connolly, James Tucker, Anthony Vice, Raymond Mortimer, (Mrs) M Done, Mr Callaghan, Nicholas Evans, John Barry, Arthur Seldon Editorial Director, Sydney Silverman, Pierre Vincent, Bryan Silcock, Sidney Marks, Michael Limb, Roger Mortimer, Antony Turner, Ernestine Carter, Desmond Shawe-Taylor, David Drew, A R C Southby, Stephen Aris, Ronald Legge, R. C. Robertson-Glasgow, Lanning Roper, Dilys Powell, Brigid Keenan, Richard Hughes, William Rees-Mogg, David Wiggins, Salmon Spray, Robert Carrier, Felix Aprahamian, Margaret Costa, Ian Coulter Industrial Correspondent, Henry Longhurst, Yvonne Lubbock, Christopher Ricks, Gerald Holden, Brian Glanville, Keith Richardson, Benny Green, Peter Dunn, Dave Phillips, Michael Green, C. H. O'd. Alexander, T. Verschoyle, Maurice Wiggin, Mr. A. Chester Beatty, Anthony Cowdy, (Miss) Anna Drake, Susan Cooper, Kenneth Konstam, Hugh Trevor-Roper, Nicholas Tomalin,
... Greek Line No Title Royal Mail Lines Reina Cristina Multiple Display Advertising Items Holiday Villas Ltd. Olympic ... The Loved Ones Senior Service The Lovers Porto Branco Sheaffer Bridge Chess Problem No. 349 Mephisto Crossword ...
1964 - Gale Group | Sunday Times HA GDA
Produção Nacional
Revisado por pares
Claudio Fukumori, Paola Cristina Branco, Thayná Lopes Barreto, Kelly Ishida, Luciana B. Lopes,
Colorectal cancer (CRC) is the third most common cancer in the world, but current chemotherapy options are limited due to adverse effects and low oral bioavailability of drugs. In this study, we investigated the obtainment parameters and composition of new multiple nanoemulsions (MN) based on microemulsions for oral co-delivery of 5-fluorouracil (5FU) and short-chain triglycerides (SCT, either tributyrin or tripropionin). The area of microemulsion formation was increased from 14% to 38% when monocaprylin ...
Tópico(s): Advanced Drug Delivery Systems
2023 - Elsevier BV | European Journal of Pharmaceutical Sciences
Cristina Branco‐Price, Colin E. Evans, Randall S. Johnson,
// Cristina Branco-Price 1 , Colin E. Evans 1 , and Randall S. Johnson 1 1 Department of Physiology, Development ...
Tópico(s): Adrenal and Paraganglionic Tumors
2013 - Impact Journals LLC | Oncotarget
Marco Gomes da Silva, M. Manuela A. Pereira, Ricardo Franco, Madalena Dionı́sio, Luı́sa M. Ferreira, Paula S. Branco, Cristina Costa, Ana Lourenço, Alice S. Pereira, Paulina Mata, João Sotomayor, João Carlos Lima, Márcia Vilarigues, A. Jorge Parola, César A. T. Laia, Isabel B. Coutinho, Luı́s C. Branco, Cláudia C. L. Pereira, Artur J. Moro, Sandra Gago, Nuno Basílio, M. Manuel B. Marques,
M. Gomes da SilvaM.M. PereiraR. FrancoM. DionisioL.M. FerreiraP. BrancoC. CostaA. LourençoA.S. PereiraP. MataJ. SotomayorJ.C. LimaM. VilariguesA.J. ParolaC.A.T. LaiaI. CoutinhoL. BrancoC. PereiraA. MoroS. GagoN. BasílioM.M. Marques
Tópico(s): Science and Science Education
2017 - International Academy of Technology, Education and Development | EDULEARN proceedings
Vasco Branco, Cristina Carvalho,
Mercury interaction with selenium in vivo has been recognized for >50 years. Several researchers attempted to use selenium to mitigate the detrimental effects of mercurial compounds but the results were controversial. Selenium pools in living organisms are quite low and the high affinity of mercury to bind selenols pointed out selenoproteins as possible targets of toxicity. Such was the case of the selenoenzyme thioredoxin reductase (TrxR) which is an integrant part of the thioredoxin system. Given ...
Tópico(s): Mercury impact and mitigation studies
2018 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - General Subjects
Luís Gabriel A. Barboza, Luís R. Vieira, Vasco Branco, Cristina Carvalho, Lúcia Guilhermino,
The presence of microplastics and several other pollutants in the marine environment is of growing concern. However, the knowledge on the toxicity of mixtures containing microplastics and other contaminants to marine species is still scarce. The main goals of this study were to investigate the oxidative stress and lipid oxidative damage potentially induced by 96 h of exposure to mercury (0.010 and 0.016 mg/L), microplastics (0.26 and 0.69 mg/L), and mixtures of the two substances (same concentrations, ...
Tópico(s): Nanoparticles: synthesis and applications
2018 - Nature Portfolio | Scientific Reports
Grant Mair, Rüdiger von Kummer, Zoë Morris, Anders von Heijne, Nick Bradey, Lesley Cala, André Peeters, Andrew Farrall, Alessandro Adami, Gillian Potter, Geoff Cohen, Peter Sandercock, Richard I. Lindley, Joanna M. Wardlaw, Peter Sandercock, Richard I. Lindley, Joanna M. Wardlaw, Colin Baigent, David Chadwick, Pippa Tyrrell, Gordon Lowe, Martin Dennis, Geoff Cohen, Karen Innes, Heather Goodare, Richard I. Lindley, Graeme J. Hankey, Karl Matz, Michael Brainin, Gord Gubitz, Stephen Phillips, Stefano Ricci, Antonio Araúz, Eivind Berge, Karsten Bruins Slot, Anna Członkowska, Adam Kobayashi, Manuel Correia, Phillippe Lyrer, Stefan T. Engelter, Veronica Murray, Andreas Terént, Bo Norrving, Per Wester, G.S. Venables, Joanna M. Wardlaw, Andrew Farrall, Zoë Morris, Rüdiger von Kummer, Lesley Cala, Anders von Heijne, Alessandro Adami, André Peeters, Gillian Potter, Nick Bradey, Joanna M. Wardlaw, Rüdiger von Kummer, Andrew Farrall, Robin Sellar, Alessandro Adami, Phil White, Andrew M. Demchuk, Matthew Adams, Grant Mair, Bernard Yan, G.S. Venables, C Blank, Helen Bowler, Cara Doyle, Keith Endean, K. Harkness, Edward F. Parker, Marc Randall, Christine Roffe, Naveed Ahmad, Anand Arora, Susan V. Brammer, J Chembala, B. Davies, Sarah J. Ellis, Richard H. Epstein, K. Finney, Chris Jackson, Changez Jadun, Ruth Kinston, Holly Maguire, I Memon, Indira Natarajan, Michael Poulson, R. Sanyal, Sheila Sills, ANNA E. M. VREEBURG, Elizabeth Ward, Peter Sandercock, Rustam Al‐Shahi Salman, Richard Davenport, Martin Dennis, Peter J. Hand, Simon P. Hart, Ingrid Kane, Sarah Keir, Mary Joan MacLeod, L McKinlay, Hazel Milligan, E SANDEMAN, Jennifer Stone, Cathie Sudlow, Peter R. Taylor, Joanna M. Wardlaw, C Warlow, William Whiteley, A. Olufemi Williams, M. Brown, B.S. Athwal, Vanessa Bassan, Neelima Bhupathiraju, John V. Bowler, Charles Davie, David Doig, Renuka Erande, Stephen Gilbert, Lionel Ginsberg, Nan Greenwood, Simone M. Gregoire, Nicola Harding, Nicholas Losseff, Robert Luder, Nathalie Passeron, Richard Perry, Philip Rayson, Robert Simister, Simon Stone, David J. Werring, James Barrett, H Aitken, Sarah Cherian, Ryan L. Davis, Susan Downham, L Godd, V. L. Gott, David José, Victoria Little, David Lowe, L Luxford, Matthew T. McGrory, Paula Owings, N Price, John Richards, Graeme Sangster, Julian Sherlock, Susan Vargese, Ian Wakefield, Pauline Weir, Paul Guyler, T Attygale, Susan M. Chandler, Lucy Coward, S Feasey, C Khuoge, Thayalini Loganathan, Sascha E. Martin, Anne Sibley O'Brien, D Sinha, Vanessa R. Thompson, Sharon Tysoe, Richard Walsh, Kerstin Metcalf, Jeffrey I. Cochius, Ryan P. Fulcher, Nisal Gange, Catherine Green, Jacqui Jagger, M Lee, Phyo Kyaw Myint, John F. Potter, Garth Ravenhill, Stephanie Shields, Naval Shinh, Tom Staunton, Eleanor Thomas, Wendy A. Woodward, P. H. L. WORTH, N. Wyatt, W Sunman, Philip M. Bath, Peter H. Berman, Judith Clarke, Catherine Gaynor, Fiona Hammonds, Rowan Harwood, Kate M. Mitchell, Soumyabrata Munshi, Sarah Pacey, Ashit Shetty, Nikola Sprigg, H Stear, G. Mani Subramanian, Andrew K. Wills, Anthony Rudd, Heinrich J. Audebert, Ajay Bhalla, Jonathan Birns, Rasheda A. Chowdhury, Gillian Cluckie, Ian G. Davies, Charlotte Gibbs, Patrick Holmes, Nicola J. Mitchell, Francesca Schiavone, Eleanor White, Meredith T. Yeung, A. Mehrzad, Vidyagauri P. Baliga, Eli M. Brown, Lewis Burnside, Bernard Esisi, Jennifer L. Kent, Orr P, David Stead, Emma Wayman, R Durairaj, C Cullen, Rohit Kumar, H Martı́n, Dermot T. McDowell, Alka Sharma, Victoria Sutton, Robert M. White, Thomas A. Hughes, Khalid Ali, J. Anderson, Katherine Baker, K Bethune, K Bethune, M Booth, M. Cossburn, Sophie Halpin, M D Hourihan, E. Neil G. Marsh, K. J. Peall, Rebecca Powell, Hamsaraj Shetty, M. Wardle, Michelle A. Williams, K Muhiddin, J. Beavan, M Clarke, R Donneley, Simon Elliott, Peter Fox, Peter H. Gorman, Margaret Harper, M Mangoyana, I Memon, Lisa Mills, L Wright, Liz Warburton, Jean‐Claude Baron, Peter Barry, Diana J. Day, Teresa Harold, Pilar Matía‐Martín, Jennifer Mitchell, Eoin O’Brien, J Rycarte, M Turnham, Geoffrey Cloud, L Y Lois Choy, Ben Clarke, C. J. Griffin, Omid Halse, Ifan Jones, Fiona Kennedy, Uzma Khan, Russell E. Lewis, Alison Loosemore, Caroline Lovelock, Markus Holtmannspötter, B. Moynihan, J. N. O'Reilly, Paul Olowoyo, Anthony Pereira, Martin Punter, Preston B. Rich, Debbie Rolfe, Francesca Schiavone, Martin James, James Bell, A. Bowring, Lucy Boxall, Julie Cageao, H. Eastwood, Salim Elyas, Fiona Hall, S. Harries, Anthony Hemsley,
Objective: To investigate whether the location and extent of the CT hyperdense artery sign (HAS) at presentation affects response to IV alteplase in the randomized controlled Third International Stroke Trial (IST-3). Methods: All prerandomization and follow-up (24–48 hours) CT brain scans in IST-3 were assessed for HAS presence, location, and extent by masked raters. We assessed whether HAS grew, persisted, shrank, or disappeared at follow-up, the association with 6-month functional outcome, and effect of alteplase. ...
Lippincott Williams & Wilkins
Fernando Maltêz, Manuela Doroana, Teresa Branco, Cristina Valente,
Purpose of review To discuss new antiretroviral agents (ARVs) and alternative ARV treatment strategies that are currently being evaluated, and to provide an overview of the most recent advances in HIV vaccine development. Recent findings There is a continuous need for improvements in ARV therapy (ART) and several new ARVs are currently undergoing clinical investigation, including the non-nucleoside reverse transcriptase inhibitor rilpivirine, the integrase inhibitor elvitegravir, the chemokine receptor ...
Tópico(s): HIV/AIDS Research and Interventions
2011 - Lippincott Williams & Wilkins | Current Opinion in HIV and AIDS
Ricardo Ferraz, Luı́s C. Branco, Cristina Prudêncio, João Paulo Noronha, Željko Petrovski,
Abstract Review: about 70 refs.
Tópico(s): Chemical Synthesis and Reactions
2011 - Wiley | ChemInform
Ricardo Ferraz, Luı́s C. Branco, Cristina Prudêncio, João Paulo Noronha, Željko Petrovski,
Abstract Ionic liquids (ILs) are ionic compounds that possess a melting temperature below 100 °C. Their physical and chemical properties are attractive for various applications. Several organic materials that are now classified as ionic liquids were described as far back as the mid‐19th century. The search for new and different ILs has led to the progressive development and application of three generations of ILs: 1) The focus of the first generation was mainly on their unique intrinsic physical and ...
Tópico(s): Electrochemical sensors and biosensors
2011 - Wiley | ChemMedChem
Filipa Júlio, Maria José Ribeiro, Miguel Patrício, Alexandre Malhão, Fábio O. Pedrosa, Hélio Gonçalves, Marco Simões, Marieke van Asselen, Mário R. Simões, Miguel Castelo‐Branco, Cristina Januário,
Introduction - Impairments in executive functions are common in neurogenetic disorders such as Huntington's disease (HD) and are thought to significantly influence the patient's functional status. Reliable tools with higher ecological validity that can assess and predict the impact of executive dysfunction in daily-life performance are needed. This study aimed to develop and validate a novel non-immersive virtual reality task ("EcoKitchen") created with the purpose of capturing cognitive and functional ...
Tópico(s): Neurological disorders and treatments
2019 - Frontiers Media | Frontiers in Psychology
Carla Lopes, Ildete L. Ferreira, Carina Maranga, M Beatriz, Sandra I. Mota, José Sereno, João Castelhano, Antero Abrunhosa, Francisco P. M. Oliveira, Maura De Rosa, Michael R. Hayden, Mário Laço, Cristina Januário, Miguel Castelo‐Branco, A. Cristina Rego,
Deficits in mitochondrial function and redox deregulation have been attributed to Huntington's disease (HD), a genetic neurodegenerative disorder largely affecting the striatum. However, whether these changes occur in early stages of the disease and can be detected in vivo is still unclear. In the present study, we analysed changes in mitochondrial function and production of reactive oxygen species (ROS) at early stages and with disease progression. Studies were performed in vivo in human brain by ...
Tópico(s): Neurological disorders and treatments
2022 - Elsevier BV | Redox Biology
Produção Nacional
Revisado por pares
Viviane Maria de Carvalho Hessel Dias, Felipe Francisco Tuon, Patrícia de Jesus Capelo, João Paulo Telles, Carlos Magno Castelo Branco Fortaleza, Cristina Pellegrino Baena,
The incidence density trend of the carbapenem-resistant Gram-negative bacteria was analysed in device-associated infections and antimicrobial consumption in 99 critical care facilities in a low/middle-income country, between January 2019 and December 2020. Carbapenem-resistant Acinetobacter baumannii (CRAB) per 1000 patient-days increased in 2020 and this finding had a strong positive correlation with the incidence density of COVID-19 by the Spearman test. Polymyxin consumption also increased in ...
Tópico(s): Global Maternal and Child Health
2021 - Elsevier BV | Journal of Hospital Infection
Produção Nacional
Revisado por pares
Guilherme Torres Vilarino, Joaquim Henrique Lorenzetti Branco, Loiane Cristina de Souza, Alexandro Andrade,
Tópico(s): Occupational Health and Performance
2022 - Springer Science+Business Media | Irish Journal of Medical Science (1971 -)
Produção Nacional
Revisado por pares
Joaquim Henrique Lorenzetti Branco, Ruy Luiz Lorenzetti Branco, Thaís Cristina Siqueira, Loiane Cristina de Souza, Keyla M.S. Dalago, Alexandro Andrade,
Rheumatic Diseases (RD) are a class of disorders of the musculoskeletal system, including different conditions, and are considered a major cause of disability among the population. RD do not have an objective and quick diagnosis and are sometimes challenging. In this way, Infrared Thermography (IT) could represent a fast and effective tool to detect essential information for diagnosing RD. Thus, the aim of this systematic review was to summarize and describe the clinical applicability of IT in RD. ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2022 - Elsevier BV | Journal of Thermal Biology
Ionel Sandovici, Aikaterini Georgopoulou, Vicente Pérez-García, Antonia Hufnagel, Jorge López‐Tello, Brian Lam, Samira Schiefer, Chelsea Gaudreau, Fátima Santos, Katharina Hoelle, Giles S.H. Yeo, Keith Burling, Moritz Reiterer, Abigail L. Fowden, Graham J. Burton, Cristina Branco, Amanda N. Sferruzzi‐Perri, Miguel Constância,
In all eutherian mammals, growth of the fetus is dependent upon a functional placenta, but whether and how the latter adapts to putative fetal signals is currently unknown. Here, we demonstrate, through fetal, endothelial, hematopoietic, and trophoblast-specific genetic manipulations in the mouse, that endothelial and fetus-derived IGF2 is required for the continuous expansion of the feto-placental microvasculature in late pregnancy. The angiocrine effects of IGF2 on placental microvasculature expansion ...
Tópico(s): Birth, Development, and Health
2021 - Elsevier BV | Developmental Cell
Produção Nacional
Revisado por pares
Diego Veras Wilke, Paula C. Jimenez, Paola Cristina Branco, Paula Rezende‐Teixeira, Amaro E. Trindade-Silva, Anelize Bauermeister, Norberto Peporine Lopes, Letícia V. Costa‐Lotufo,
Abstract “Blue Amazon” is used to designate the Brazilian Economic Exclusive Zone, which covers an area comparable in size to that of its green counterpart. Indeed, Brazil flaunts a coastline spanning 8000 km through tropical and temperate regions and hosting part of the organisms accredited for the countryʼs megadiversity status. Still, biodiversity may be expressed at different scales of organization; besides species inventory, genetic characteristics of living beings and metabolic expression of ...
Tópico(s): Synthesis of Organic Compounds
2020 - Thieme Medical Publishers (Germany) | Planta Medica
Adam Leach, Peter Smyth, Laura T. Ferguson, John Steven, Michelle K. Greene, Cristina Branco, Aidan McCann, A.J. Porter, Caroline J. Barelle, Christopher J. Scott,
Anti-DLL4 VNAR targeted nanoparticles – a novel targeting ligand towards an under-investigated target.
Tópico(s): Radiopharmaceutical Chemistry and Applications
2020 - Royal Society of Chemistry | Nanoscale
Produção Nacional
Revisado por pares
Paola Cristina Branco, Cristine A. Pontes, Paula Rezende‐Teixeira, Pep Amengual-Rigo, Débora Kristina Alves-Fernandes, Silvya Stuchi Maria‐Engler, Alison B. da Silva, Otília Deusdênia Loiola Pessoa, Paula C. Jimenez, Niloufar Mollasalehi, Eli Chapman, Vı́ctor Guallar, João Agostinho Machado‐Neto, Letícia V. Costa‐Lotufo,
Melanoma is a type of skin cancer with an elevated incidence of metastasis and chemoresistance. Such features hamper treatment success of these neoplasms, demanding the search for new therapeutic options. Using a two-step resin-based approach, we recently demonstrated that cytotoxic prodiginines bind to the inhibitor of apoptosis protein, survivin. Herein, we explore the role of survivin in melanoma and whether its modulation is related to the antimelanoma properties of three cytotoxic prodiginines ( ...
Tópico(s): Microbial Natural Products and Biosynthesis
2020 - Elsevier BV | European Journal of Pharmacology
Produção Nacional
Revisado por pares
Paula C. Jimenez, Diego Veras Wilke, Paola Cristina Branco, Anelize Bauermeister, Paula Rezende‐Teixeira, Susana P. Gaudêncio, Letícia V. Costa‐Lotufo,
Marine natural products have proven, over the last half‐century, to be effective biological modulators. These molecules have revealed new targets for cancer therapy as well as dissimilar modes of action within typical classes of drugs. In this scenario, innovation from marine‐based pharmaceuticals has helped advance cancer chemotherapy in many aspects, as most of these are designated as first‐in‐class drugs. Here, by examining the path from discovery to development of clinically approved drugs of ...
Tópico(s): Synthesis and Biological Activity
2019 - Wiley | British Journal of Pharmacology
Moritz Reiterer, Cristina Branco,
The microvasculature is a heterogeneous, dynamic and versatile component of the systemic circulation, with a unique ability to locally self‐regulate and to respond to organ demand and environmental stimuli. Endothelial cells from different organs display considerable variation, but it is currently unclear to what extent functional properties of organ‐specific endothelial cells are intrinsic, acquired and/or reprogrammable. Vascular function is a fundamental pillar of homeostasis, and dysfunction ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2019 - Wiley | FEBS Journal
Moritz Reiterer, Renato Colaço, Pardis Emrouznejad, Anders Jensen, Helene Rundqvist, Randall S. Johnson, Cristina Branco,
Abstract Oscillations in oxygen levels affect malignant cell growth, survival, and metastasis, but also somatic cell behaviour. In this work, we studied the effect of the differential expression of the two primary hypoxia inducible transcription factor isoforms, HIF-1α and HIF-2α, and pulmonary hypoxia to investigate how the hypoxia response of the vascular endothelium remodels the lung pre-metastatic niche. Molecular responses to acute versus chronic tissue hypoxia have been proposed to involve ...
Tópico(s): Angiogenesis and VEGF in Cancer
2019 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Marcelo González‐Aravena, Carolina Perez-Troncoso, Rocío Urtubia, Paola Cristina Branco, José Roberto Machado Cunha da Silva, Luís Mercado, Julien de Lorgeril, Jörn Bethke, Kurt Paschke,
In the Antarctic marine environment, the water temperature is usually between 2 and - 1.9 °C. Consequently, some Antarctic species have lost the capacity to adapt to sudden changes in temperature. The study of the immune response in Antarctic sea urchin (Sterechinus neumayeri) could help us understand the future impacts of global warming on endemic animals in the Antarctic Peninsula. In this study, the Antarctic sea urchins were challenged with lipopolysaccharides and Vibrio alginolitycus. The cellular ...
Tópico(s): Marine Bivalve and Aquaculture Studies
2016 - Vicerractoría Investigación | Revista de Biología Tropical
Produção Nacional
Revisado por pares
A.W.B. Silva, Larissa Alves Guimarães, Elthon G. Ferreira, M. Torres, A. Silva, Paola Cristina Branco, Francisca Andréa Silva Oliveira, Genivaldo Gueiros Z. Silva, Diego Veras Wilke, Edilberto R. Silveira, Otília Deusdênia Loiola Pessoa, Paula C. Jimenez, Letícia V. Costa‐Lotufo,
The actinomycete strain BRA 177 was recovered from sediment samples collected at the St.Peter and St. Paul Archipelago
Tópico(s): Biological Stains and Phytochemicals
2016 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society
Andrew S. Cowburn, Alexi Crosby, David Macías, Cristina Branco, Renato Colaço, Mark Southwood, Mark Toshner, Laura E. Crotty Alexander, Nicholas W. Morrell, Edwin R. Chilvers, Randall S. Johnson,
Significance The expression of hypoxia-inducible factor (HIF)-2α in pulmonary endothelium of mice influences pulmonary vascular resistance and development of hypoxic pulmonary hypertension (PH) via an arginase-1–dependent mechanism. The HIF-2α:arginase-1 axis influences the homeostatic regulation of nitric oxide synthesis in the lung. Impaired generation of this vasoactive agent contributes to the initial development and vascular remodeling process of PH.
Tópico(s): High Altitude and Hypoxia
2016 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Produção Nacional
Revisado por pares
Débora Alvares Leite Figueiredo, Paola Cristina Branco, Douglas Amaral dos Santos, Andrews Krupinski Emerenciano, Renata Stecca Iunes, Jõao Carlos Shimada Borges, José Roberto Machado Cunha da Silva,
The rising concentration of atmospheric CO2 by anthropogenic activities is changing the chemistry of the oceans, resulting in a decreased pH. Several studies have shown that the decrease in pH can affect calcification rates and reproduction of marine invertebrates, but little attention has been drawn to their immune response. Thus this study evaluated in two adult tropical sea urchin species, Lytechinus variegatus and Echinometra lucunter, the effects of ocean acidification over a period of 24h ...
Tópico(s): Coral and Marine Ecosystems Studies
2016 - Elsevier BV | Aquatic Toxicology
Hideki Yamamoto, Helene Rundqvist, Cristina Branco, Randall S. Johnson,
Vascular endothelial growth factor A (VEGF) is involved in all the essential biology of endothelial cells, from proliferation to vessel function, by mediating intercellular interactions and monolayer integrity. It is expressed as three major alternative spliced variants. In mice, these are VEGF120, VEGF164, and VEGF188, each with different affinities for extracellular matrices and cell surfaces, depending on the inclusion of heparin-binding sites, encoded by exons 6 and 7. To determine the role of ...
Tópico(s): Nitric Oxide and Endothelin Effects
2016 - Frontiers Media | Frontiers in Cell and Developmental Biology
Produção Nacional
Revisado por pares
Ivanise Guilherme Branco, Izabel Cristina Freitas Moraes, Eliana Janet Sanjinez‐Argandoña, Grasiele Scaramal Madrona, Catarina dos Santos, Ana Lúcia Tasca Góis Ruiz, João Ernesto de Carvalho, Charles Windson Isidoro Haminiuk,
Here we analyze jambolan pulp phenolic compounds in order to establish a correlation with antioxidant and in vitro anti-proliferative effects, both before and after pasteurization. Total levels of phenolic compounds, flavonoids and anthocyanins were quantified using UV–vis techniques. Major phenolic compounds were identified by standard compound co-injection in HPLC-DAD/UV–vis. Antioxidant activity was measured by radical scavenging ability, as determined by DPPH assay. In vitro anti-proliferative ...
Tópico(s): Plant tissue culture and regeneration
2016 - Elsevier BV | Industrial Crops and Products
Tom Ashmore, Lee D. Roberts, Andrea J. Morash, Aleksandra Kotwica, John R. Finnerty, James A. West, Steven A. Murfitt, Bernadette Fernandez, Cristina Branco, Andrew S. Cowburn, Kieran Clarke, Randall S. Johnson, Martin Feelisch, Julian L. Griffin, Andrew J. Murray,
Insulin sensitivity in skeletal muscle is associated with metabolic flexibility, including a high capacity to increase fatty acid (FA) oxidation in response to increased lipid supply. Lipid overload, however, can result in incomplete FA oxidation and accumulation of potentially harmful intermediates where mitochondrial tricarboxylic acid cycle capacity cannot keep pace with rates of β-oxidation. Enhancement of muscle FA oxidation in combination with mitochondrial biogenesis is therefore emerging ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2015 - BioMed Central | BMC Biology
Colin E. Evans, Pär‐Ola Bendahl, Mattias Belting, Cristina Branco, Randall S. Johnson,
Key Points Cell-specific hypoxia-inducible factor 1 can regulate cancer-associated hypercoagulation and thrombus formation.
Tópico(s): Cardiac tumors and thrombi
2015 - Elsevier BV | Blood