Maria João Cruz, Alberto Mota, Teresa Baudrier, Elisa Silva, Catarina Eloy, Filomena Azevedo,
... ção no gene da prolidase (PEPD), localizado no cromossoma 19. A deficiência desta enzima diminui a reciclagem de ...
Tópico(s): Protease and Inhibitor Mechanisms
2011 - | Journal of the Portuguese Society of Dermatology and Venereology
Patrícia Couceiro, Vítor Sousa, Ana Alarcão, Maria Silva, Lina Carvalho,
The epidermal growth factor receptor (EGFR) is overexpressed in the majority of nonsmall- cell lung cancers (NSCLC) and is a major target specific EGFR tyrosine kinase inhibitors (TKIs) developed and used for the treatment of advanced NSCLC. A number of biological factors are also associated with EGFR-TKIs responsiveness. This study was focused on EGFR somatic mutations and amplifications in squamous cell lung cancer.Representative sections of squamous cell carcinoma were selected from 54 surgical ...
Tópico(s): Plant Disease Resistance and Genetics
2010 - Elsevier BV | Revista Portuguesa de Pneumologia
Patrícia Couceiro, Vítor Sousa, Ana Alarcão, Maria João Silva, Lina Carvalho,
... Cappuzzo (2005). A pesquisa de alterações génicas no cromossoma 7 e do gene EGFR foram analisadas por FISH e de acordo com o método de Cappuzzo (2005), foi identificada alta polissomia em 31 casos e amplificação em 7 casos. Por electroforese capilar, foram detectadas no exão 19 do EGFR: deleções em heterozigotia em 3 dos ...
Tópico(s): Lung Cancer Treatments and Mutations
2010 - Elsevier BV | Revista Portuguesa de Pneumologia