Robert Trotter, Azra Aziz, Waldemar Januszczak, Michael Prescott, Steve Lawless, Philip Marsden, John Dugdale, Gillian MacKley, Matthew Wall, lain Morrison, Barbara Hall, Suzannah Olivier, Nigel Botherway, Sebastian Faulks, Hugh McManns, Fred Redwood, Jon Swain, Philip Norman, Nicholas Rufford, John Peter, Nicholas Lezard, Pam Barrett, Elizabeth Miekle, Amanda Ursell, Emma Moore, George Pendle, Arthur Rose, John Jay, Dan Buxton, Fellma Whitbread, Frank Whitford, Sheridan Morley, Ivo Tennant, Lucy Hughes-Hallett, David Smith, Kirstie Hamilton City Editor, Chris Dignan, Melanie Phillips, D J Ferris, Nick Pitt, Neil Wormald, Lucy Irvine, Andrew Sullivan, Clive Davis, Stephen Grey, Mary Wilson, Tony Allen-Mills, Simon Wilde, Martin James, Robert Sandall, Dr Alan Bullion, Anthony Sattin, Sir John Mills, Shella Clayton, Irwin Stelzer, Peter Wilson, Roger Anderson, Marian Phillips, David Dougill, Jeremy Chance, John Evans, Irene Collins, David Hewson, Tania Alexander, Harvey Porlock, William Dalrymple, Margaret Coles, Jonathon Carr-Brown, Margarette Driscoll, Joan Tudor, Ben Radford, Hugh Mcllvanney, Gerald Scarfe, David Cairns, Edward Porter, Steve Coogan, Betrayal, Louise Taylor, John Waples Deputy City Editor, Stewart Lee, Dr Morris Nitsun, Robert Harris, Nick Newman's, J G, David Eimer, Natasha Narayan, Cathy Scott-Clark, Graham Otway, Robin Marlar, Nick Gardner, Paul Daniel, Shelley von Strunckel, Peter Parker, Mike Laws, Richard Johnson, Christine Barrow, Winner, M Day, Thomas Hearns, Paul Donovan, Jean Pitt, Barbara Hendricks, Steve Waugh, Frances Spalding, Angela Newing, Sue Lawrence, Smita Talati, Paul Driver, Paul Bray, Owen Cima, Martica Heaner, Simon Fanshawe, Boris Schapiro, Maeve Sheehan, Ian Hawkey, Richard Girling, Dr Michael Humphreys, Dave Hannigan, Michael Prescott Chief Political Correspondent, Kirstie Hamilton, Alicia Wyllie, Rebecca Bradley, Tom Shone, Mark Edwards, Susan Clark, David Lawrenson, John Halow, Nicholas Rufford Home Affairs Editor, John Foliain, Julie Dorrell, Lord Hanson, Zoe Brennan Westminster Correspondent, R S, Phil Baker, Hugh Canning, John Harlow Arts Correspondent, Tom Shakespeare, Jennifer Asiama, Anne Barrowclough, Moses, Raymond Keene, Cralg Lord, Douglas Alexander, Cosmo Landesman, Zoe Brennan, Andrew Roberts, Marie Colvin, David Kells, Douglas Ennedy, Diana Wright, Kipper Williams, Helen Hawkins, Stephen Jones, Nick Cain, Stephen Bevan, Andrew Smith, Paul Nuki, David Pleat, Tony Allen Mills, Hugh McManners, Martin Searby, Keith Wheatley, Claire Oldfield, David Walsh, Mary Archer, David Maguire, Oliver Peck, Jack Grimston, Debora Patta, Lucy, Bryan Appleyard, Trevor Lewis, Ron Clarke, Michael Berkeley, Mark Macaskill, Paul Kavanagh, Mark Prigg, R W Johnson, Nick Harvey, Josh Salzmann, Christopher Goodwin, D H, Garth Alexander, Emma Marlin, William Rees-Mogg, Maurice Chittenden, Alex Fortune, Kevin Pratt, Ron Potts, Andrew Lorenz Business Editor, David Rees, Mark Franchetti, Jonathan Powell, Craig Lord, Jon Ungoed-Thomas, Ray Hutton, Peter Watts, Tom Mair, Michael Sheridan, Sean Hargrave, Niall Ferguson, Margaret Walters, Emmanuel Steward, Matthew Lynn, Nicola Horlick, Clare Brown, Michael Hodges, Kate Thornton, Mandy Payne, John Waples, Terry Murden, A A Gill, David Parsons, Carmen, Matthew Campbell, Brian Glanville, John Carey, David Hutcheon, Tom Robbins, David Sumner Smith, Christine Lynch, Jo Viccari, Robert Johnston, Stephen Pettitt, Jonathan Carr-Brown, Peter Stearn, Kevin Goldstein-Jackson, Cherry Norton, Chrissy Iley, Sally Kinnes, Andrew Lorenz, Naomi Caine, Liam Clarke, Adrian Levy, David Wickers, Jane Hardy, Sam Lowther, Tom Rhodes, R Charter, Jo Howlett, Mark Hodson, Andrew Frankel, Nicholas Hellen Media Correspondent, Joe Lovejoy, Jonathan Futrell, Rupert Steiner, Hugh Pearman, David Parsley, Mrs Mills, David Smith Economics Editor, Maurice Sherlock, Anthony Howard, Carey Scott, Nicholas Kenyon, Bob Dwyer, Walter Ellis, Joanna Simon, Lord Rogers, Simon Howard, Barry Newcombe, William Gray, Georgina Howell, Karen Robinson, Zoe Heller,
... sacrifices: the perils of marrying a Zulu prince Debora Patta, a guest at this weekend's Channel ...
1998 - Gale Group | Sunday Times HA GDA
Produção Nacional
Revisado por pares
Fernanda de Paula Eduardo, Luciana Corrêa, Débora Heller, Carlo Amorin Daep, Carlos Benítez, Zilson Malheiros, Bernal Stewart, Maria Ryan, Clarisse Martins Machado, Nelson Hamerschlak, João Renato Rebello Pinho, Letícia Mello Bezinelli,
The saliva of patients with COVID-19 has a high SARS-CoV-2 viral load. The risk of spreading the virus is high, and procedures for viral load reduction in the oral cavity are important. Little research to date has been performed on the effect of mouthwashes on the salivary SARS-CoV-2 viral load. This pilot randomized single-center clinical trial investigated whether three types of mouthwash with solutions containing either 0.075% cetylpyridinium chloride plus 0.28% zinc lactate (CPC + Zn), 1.5% hydrogen ...
Tópico(s): SARS-CoV-2 detection and testing
2021 - Elsevier BV | Heliyon
Produção Nacional
Vitor Ulisses Monnaka, Camila Hernandes, Débora Heller, Sérgio Podgaec,
Objective The aim of the study was to assess the evidence on miRNAs as biomarkers for the diagnosis of endometriosis, as well as to provide insights into the challenges and strategies associated with the use of these molecules as accessible tools in clinical practice. Methods Systematic review conducted on PubMed®, Latin American and Caribbean Health Sciences Literature (LILACS), MEDLINE® and Web of Science databases using the search terms endometriosis (all fields) AND miRNA (all fields), evaluating ...
Tópico(s): Endometrial and Cervical Cancer Treatments
2021 - Instituto Israelita de Ensino e Pesquisa Albert Einstein | Einstein (São Paulo)
Produção Nacional
Revisado por pares
Tatiane Fernandes Novaes, Maísa Camillo Jordão, Carlos Felipe Bonacina, André VERONEZI, Carlos Ariel Rodrigues de Araújo, Isabel Cristina Olegário, Daniele Boina de Oliveira, Veranika Ushakova, Alexander Birbrair, Danielle da Costa Palácio, Débora Heller,
The state of São Paulo, Brazil, where more than 94.000 dentists are currently registered, has become the epicenter of COVID-19 in Latin America. The aim of this cross-sectional study was to evaluate the impact of COVID-19 pandemic on dentists in this state. A semi-structured questionnaire was sent via e-mail to 93.280 dentists with active registration in the Dental Council of São Paulo (CROSP). The impact of COVID-19 pandemic was assessed through questions related to demographic, socioeconomic, dental ...
Tópico(s): COVID-19 and healthcare impacts
2021 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Larissa Leci Fernandes, Valéria Bordallo Pacheco, Leandro Borges, Harleen K. Athwal, Fernanda de Paula Eduardo, Letícia Mello Bezinelli, Luciana Corrêa, Manuel Jiménez, Nailê Damé‐Teixeira, Isabelle M.A. Lombaert, Débora Heller,
This review presents literature that highlights saliva's utility as a biofluid in the diagnosis and monitoring of COVID-19. A systematic search was performed in 5 electronic databases (PubMed, Embase, LILACS, Scopus, and Web of Science). Studies were eligible for inclusion if they assessed the potential diagnostic value and/or other discriminatory properties of biological markers in the saliva of patients with COVID-19. As of July 22, 2020, a total of 28 studies have investigated the presence of ...
Tópico(s): SARS-CoV-2 detection and testing
2020 - SAGE Publishing | Journal of Dental Research
Produção Nacional
Revisado por pares
Maria Fernanda Marques Silva de Carvalho, Denise Cavalieri, Sabrina do Nascimento, Talita Gomes Baêta Lourenço, Danielle Viana Ribeiro Ramos, Denise da Cunha Pasqualin, Leandro Aurélio Liporoni Martins, Fernanda Agostini Rocha, Débora Heller, Luciana Cavalheiro Marti,
Oral lichen planus (OLP) is a chronic Th1-mediated inflammatory mucocutaneous disease of the skin and oral mucosa that can have various clinical presentations. Lesions are usually bilateral and often painful. While cutaneous Lichen Planus (LP) lesions are self-limiting, the oral lesions are chronic and rarely remissive. The diagnosis of oral lichen planus (OLP) is often challenging, and confirmation by histopathological criterion is generally advised. The aim of our study was to identify the cytokines ...
Tópico(s): Salivary Gland Tumors Diagnosis and Treatment
2019 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Walison N. Silva, Caroline Leonel, Pedro H. D. M. Prazeres, Isadora F. G. Sena, Daniel Guerra, Débora Heller, Ivana Márcia Alves Diniz, Vitor Fortuna, Akiva Mintz, Alexander Birbrair,
Dermal wound healing is the process of repairing and remodeling skin following injury. Delayed or aberrant cutaneous healing poses a challenge for the health care system. The lack of detailed understanding of cellular and molecular mechanisms involved in this process hampers the development of effective targeted treatments. In a recent study, Parfejevs et al.-using state-of-the-art technologies, including in vivo sophisticated Cre/loxP techniques in combination with a mouse model of excisional cutaneous ...
Tópico(s): Burn Injury Management and Outcomes
2018 - Wiley | Wound Repair and Regeneration
Débora Heller, Eva J. Helmerhorst, Adam C. Gower, Walter L. Siqueira, Bruce J. Paster, Frank G. Oppenheim,
Although the mature dental biofilm composition is well studied, there is very little information on the earliest phase of in vivo tooth colonization. Progress in dental biofilm collection methodologies and techniques of large-scale microbial identification have made new studies in this field of oral biology feasible. The aim of this study was to characterize the temporal changes and diversity of the cultivable and noncultivable microbes in the early dental biofilm. Samples of early dental biofilm ...
Tópico(s): Dental Erosion and Treatment
2016 - American Society for Microbiology | Applied and Environmental Microbiology
Débora Heller, Eva J. Helmerhorst, Frank G. Oppenheim,
The acquired enamel pellicle is an oral, fluid-derived protein layer that forms on the tooth surface. It is a biologically and clinically important integument that protects teeth against enamel demineralization, and abrasion. Tooth surfaces are exposed to different proteinaceous microenvironments depending on the enamel location. For instance, tooth surfaces close to the gingival sulcus contact serum proteins that emanate via this sulcus, which may impact pellicle composition locally. The aims of ...
Tópico(s): Periodontal Regeneration and Treatments
2016 - SAGE Publishing | Journal of Dental Research
Produção Nacional
Revisado por pares
Talita Gomes Baêta Lourenço, Débora Heller, Carina Maciel Silva‐Boghossian, Sean L. Cotton, Bruce J. Paster, Ana Paula Vieira Colombo,
Abstract Aim To determine microbial profiles that discriminate periodontal health from different forms of periodontal diseases. Methods Subgingival biofilm was obtained from patients with periodontal health (27), gingivitis (11), chronic periodontitis (35) and aggressive periodontitis (24), and analysed for the presence of >250 species/phylotypes using HOMIM . Microbial differences among groups were examined by Mann–Whitney U ‐test. Regression analyses were performed to determine microbial risk indicators ...
Tópico(s): Dental Radiography and Imaging
2014 - Wiley | Journal Of Clinical Periodontology
Produção Nacional
Revisado por pares
Débora Heller, Carina Maciel Silva‐Boghossian, Renata Souto, Ana Paula Vieira Colombo,
The aim of this study was to distinguish between generalized aggressive (GAgP) and chronic periodontitis (CP) based on the subgingival microbial profiles predominant in these diseases.Two-hundred and sixty subjects, 75 with GAgP and 185 with CP were recruited. Full-mouth clinical measurements were recorded. Individual subgingival plaque samples were taken from 7 sites per subject and analyzed for the prevalence and levels of 51 species by chequerboard. Differences between groups were examined by the ...
Tópico(s): Streptococcal Infections and Treatments
2012 - Elsevier BV | Archives of Oral Biology
Produção Nacional
Revisado por pares
Mayra Xavier E Silva-Senem, Débora Heller, Victor Macedo Varela, Maria Cynésia Medeiros de Barros, Eduardo J. Feres‐Filho, Ana Paula Vieira Colombo,
Abstract Aim To compare the 1‐year clinical and microbiological outcomes of an enhanced anti‐infective therapy with versus without systemic antimicrobials in patients with generalized aggressive periodontitis (GAP). Methods In this 12‐month randomized, double‐blinded, placebo‐controlled trial, 35 individuals assigned to a control ( n = 17) or test group ( n = 18) received full‐mouth supra and subgingival ultrasonic debridement followed by scaling and root planing with chlorhexidine rinsing, brushing, and ...
Tópico(s): Dental Research and COVID-19
2012 - Wiley | Journal Of Clinical Periodontology
Produção Nacional
Revisado por pares
Débora Heller, Victor Macedo Varela, Mayra Xavier E Silva-Senem, Maria Cynésia Medeiros de Barros, Eduardo J. Feres‐Filho, Ana Paula Vieira Colombo,
Heller D, Varela VM, e Silva-Senem MX, Torres MCB, Feres-Filho EJ, Colombo APV: Impact of systemic antimicrobials combined to anti-infective mechanical debridement on the microbiota of generalized aggressive periodontitis: a 6-month RCT. J Clin Periodontol 2011; 38: 355–364. doi: 10.1111/j.1600-051X.2011.01707.x Aim: To compare the effects of systemic amoxicillin (AMX) plus metronidazole (MET) or placebos combined with anti-infective mechanical debridement on the sub-gingival microbiota of generalized ...
Tópico(s): Dental Radiography and Imaging
2011 - Wiley | Journal Of Clinical Periodontology
Produção Nacional
Revisado por pares
Victor Macedo Varela, Débora Heller, Mayra Xavier E Silva-Senem, Maria Cynésia Medeiros de Barros, Ana Paula Vieira Colombo, Eduardo J. Feres‐Filho,
Background: The purpose of this study is to compare the additional benefit of systemic antimicrobials versus placebos to a repeated mechanical instrumentation combined with comprehensive local chemical plaque control for the periodontal treatment of generalized aggressive periodontitis (GAgP). Methods: This was a 6‐month randomized, double‐masked, placebo‐controlled clinical trial. All GAgP patients received full‐mouth disinfection followed by staged scaling and root planing without (placebo group; ...
Tópico(s): Dental Research and COVID-19
2011 - Wiley | Journal of Periodontology
Produção Nacional
Revisado por pares
Fernanda de Paula Eduardo, Letícia Mello Bezinelli, Carlos Ariel Rodrigues de Araújo, João Vitor Vanderlan Moraes, Alexander Birbrair, João Renato Rebello Pinho, Nelson Hamerschlak, Ibtisam Al‐Hashimi, Débora Heller,
The presence of SARS-CoV-2 virus in the saliva of patients infected with COVID-19 has been confirmed by several studies. However, the use of saliva for the diagnosis of COVID-19 remains limited, because of the discrepancies in the results, which might be due to using different saliva sampling methods. The purpose of this study was to compare the consistency of SARS-CoV-2 detection using two different saliva sampling methods (oral swab and unstimulated saliva) to that of the standard nasopharyngeal ...
Tópico(s): COVID-19 diagnosis using AI
2021 - Springer Nature | Clinical Oral Investigations
Produção Nacional
Revisado por pares
Talita Gomes Baêta Lourenço, Débora Heller, Renata Souto, Mayra Xavier E Silva-Senem, Victor Macedo Varela, Maria Cynésia Medeiros de Barros, Eduardo J. Feres‐Filho, Ana Paula Vieira Colombo,
This study evaluates the antimicrobial susceptibility and composition of subgingival biofilms in generalized aggressive periodontitis (GAP) patients treated using mechanical/antimicrobial therapies, including chlorhexidine (CHX), amoxicillin (AMX) and metronidazole (MET). GAP patients allocated to the placebo (C, n = 15) or test group (T, n = 16) received full-mouth disinfection with CHX, scaling and root planning, and systemic AMX (500 mg)/MET (250 mg) or placebos. Subgingival plaque samples were obtained ...
Tópico(s): Streptococcal Infections and Treatments
2015 - Springer Nature | Brazilian Journal of Microbiology
Produção Nacional
Revisado por pares
Jéssica Luiza de Mendonça Albuquerq Melo, Camila Pinho e Souza Coelho, Fernanda de Paula e Silva Nunes, Débora Heller, Daniela Corrêa Grisi, Maria do Carmo Machado Guimarães, Nailê Damé‐Teixeira,
Several systemic conditions can result in distinct degrees of salivary gland damage and consequent hypofunction. The development of successful management schemes is highly challenging due to the complexity of saliva. This study aimed to systematically map the literature on the physical stimulation of salivary glands for hyposalivation management and the response of individuals according to different systemic conditions causing salivary impairment.A systematic search in the literature was performed. ...
Tópico(s): Acupuncture Treatment Research Studies
2023 - BioMed Central | BMC Oral Health
Produção Nacional
Revisado por pares
Valéria Bordallo Pacheco, Giulia Christie Lamberti Nery, Larissa Leci Fernandes, Thais Viggiani Santana, Manuel Jiménez, Leandro Borges, Elaine Hatanaka, Pedro Luiz Garcia Braga, Fernanda Rodrigues Monteiro, Jônatas Bussador do Amaral, Luana Severo Alves, André Luís Lacerda Bachi, Sérgio Gomes da Silva, Alexander Birbrair, Débora Heller,
Since aging has been associated with increased production of inflammatory biomarkers, the ability to monitor older adults repeatedly is highly desirable, and saliva is an interesting biofluid for the search of biomarkers, as it is easily accessible in a noninvasive manner. However, given the incipient knowledge of salivary biomarkers in aging and its relationship to physical exercise, the present study is aimed at evaluating the protein expression and the levels of inflammatory and NETosis biomarkers ...
Tópico(s): Bone and Dental Protein Studies
2022 - Hindawi Publishing Corporation | Oxidative Medicine and Cellular Longevity
Produção Nacional
Revisado por pares
Isadora F. G. Sena, Beatriz G. S. Rocha, Caroline C. Picoli, Gabryella S. P. Santos, Alinne C. Costa, Bryan Ôrtero Perez Gonçalves, Ana P. V. Garcia, Maryam Soltani-asl, Leda M. C. Coimbra-Campos, Walison N. Silva, Pedro Augusto Carvalho Costa, Mauro Cunha Xavier Pinto, Jaime Henrique Amorim, Vasco Azevedo, Rodrigo R. Resende, Débora Heller, Geovanni Dantas Cassali, Akiva Mintz, Alexander Birbrair,
Tópico(s): Cancer-related Molecular Pathways
2021 - Springer Science+Business Media | Histochemistry and Cell Biology
Produção Nacional
Revisado por pares
Fernanda de Paula Eduardo, Luciana Corrêa, Fernanda Mansur, Carlos Benítez, Nelson Hamerschlak, João Renato Rebello Pinho, Débora Heller, Letícia Mello Bezinelli,
The effect of toothpastes on viruses, such as SARS-CoV-2, is unknown. This study investigated the short-term effect of toothpastes containing antimicrobial properties in patients with novel coronavirus disease 2019 (COVID-19) to determine whether they could reduce the SARS-CoV-2 salivary viral load.Hospitalised patients with COVID-19 (n = 83) were instructed to perform toothbrushing with 1 of 3 arms: a toothpaste containing 0.96% zinc (zinc oxide, zinc citrate) in a silica base (Test 1), a toothpaste ...
Tópico(s): Oral microbiology and periodontitis research
2022 - Elsevier BV | International Dental Journal
Produção Nacional
Revisado por pares
Juliana de Melo Batista dos Santos, Jônatas Bussador do Amaral, Carolina Nunes França, Fernanda Rodrigues Monteiro, Anuska Marcelino Alvares-Saraiva, Sandra Kalil Bussadori, Edison Luíz Durigon, Danielle Bruna Leal Oliveira, Silvia Sanches Rodrigues, Débora Heller, Eliane Aparecida Rosseto Welter, João Renato Rebello Pinho, Rodolfo P. Vieira, André Luís Lacerda Bachi,
Background Relevant aspects regarding the SARS-CoV-2 pathogenesis and the systemic immune response to this infection have been reported. However, the mucosal immune response of the upper airways two months after SARS-CoV-2 infection in patients with mild/moderate symptoms is still not completely described. Therefore, we investigated the immune/inflammatory responses of the mucosa of the upper airways of mild/moderate symptom COVID-19 patients two months after the SARS-CoV-2 infection in comparison ...
Tópico(s): Dermatological and COVID-19 studies
2022 - Frontiers Media | Frontiers in Immunology
Produção Nacional
CH Habibe, Ryotaro Yoshida, Renata Gorjão, Gabriela-Mancia Gutierrez, Débora Heller, Alexander Birbrair, Maria Teresa Botti Rodrigues Santos,
Background: Individuals with Down syndrome (DS) present increased susceptibility to infections and high prevalence of periodontal disease.The objective of this study is to evaluate the salivary concentrations of IL-1β, IL-6, IL-8, IL-10, TNFα and IL-12p70 of DS individuals and compare to cerebral palsy (CP) and normoactive patients (all with gingivitis).Material and Methods: Twenty-two individuals with DS, 24 with CP and 22 normoactive participated in this cross-sectional study.Salivary flow rate, ...
Tópico(s): Diabetic Foot Ulcer Assessment and Management
2020 - Medicina Oral S.L. | Journal of Clinical and Experimental Dentistry
Produção Nacional
Revisado por pares
Isadora F. G. Sena, Larissa Leci Fernandes, Leonardo Lima Lorandi, Thais Viggiani Santana, Luciana Cintra, Ismael Feitosa Lima, Leo Kei Iwai, Jill M. Kramer, Alexander Birbrair, Débora Heller,
Breast cancer is one of leading causes of death worldwide in the female population. Deaths from breast cancer could be reduced significantly through earlier and more efficient detection of the disease. Saliva, an oral fluid that contains an abundance of protein biomarkers, has been recognized as a promising diagnostic biofluid that is easy to isolate through non-invasive techniques. Assays on saliva can be performed rapidly and are cost-effective. Therefore, our work aimed to identify salivary biomarkers ...
Tópico(s): Cancer Research and Treatments
2022 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Raquel Lopes dos Santos, Manuela da Silva Spinola, Ellen Carvalho, Dênis Clay Lopes dos Santos, Nailê Damé‐Teixeira, Débora Heller,
The aim of this randomised clinical trial was to evaluate the effects of a mobile application (app) on the oral hygiene (OH) of adolescents undergoing fixed orthodontic treatment.
Tópico(s): Dental Research and COVID-19
2022 - Elsevier BV | International Dental Journal
Nadine Janis Pohontsch, Kathrin Heser, Antje Löffler, Britta Haenisch, Debora Parker, Tobias Luck, Steffi G. Riedel‐Heller, Wolfgang Maier, Frank Jessen, Martin Scherer,
Potentially inappropriate medication (PIM) is defined as medication with uncertain therapeutic effects and/or potential adverse drug reactions outweighing the clinical benefits. The prescription rate of PIM for oldest-old patients is high despite the existence of lists of PIM (e.g. the PRISCUS list) and efforts to raise awareness. This study aims at identifying general practitioners' views on PIM and aspects affecting the (long-term) use of PIM.As part of the CIM-TRIAD study, we conducted semi-structured, ...
Tópico(s): Pharmaceutical studies and practices
2017 - Springer Science+Business Media | BMC Family Practice
Produção Nacional
Revisado por pares
Michele Macedo Moraes, Thiago Teixeira Mendes, Leandro Borges, Alice Lamounier Marques, Cristián Núñez-Espinosa, Dawit A. P. Gonçalves, Carolina B. Simões, Tales Sambrano Vieira, Roberto Vagner Puglia Ladeira, Talita Gomes Baêta Lourenço, Danielle Viana Ribeiro, Elaine Hatanaka, Débora Heller, Rosa Maria Esteves Arantes,
Antarctic camps pose psychophysiological challenges related to isolated, confined, and extreme (ICE) conditions, including meals composed of sealed food. ICE conditions can influence the microbiome and inflammatory responses. Seven expeditioners took part in a 7-week Antarctic summer camp (Nelson Island) and were evaluated at Pre-Camp (i.e., at the beginning of the ship travel), Camp-Initial (i.e., 4th and 5th day in camp), Camp-Middle (i.e., 19th-20th, and 33rd-34th days), Camp-Final (i.e., 45th-46th ...
Tópico(s): Nutritional Studies and Diet
2023 - Multidisciplinary Digital Publishing Institute | Microorganisms
Produção Nacional
Revisado por pares
Camila Pinho e Souza Coelho, Jéssica Luiza Mendonça Albuquerque de Melo, Fernanda de Paula e Silva Nunes, Maria do Carmo Machado Guimarães, Débora Heller, Daniela Corrêa Grisi, Nailê Damé‐Teixeira,
Objective(s) This scoping review aims to map the scientific literature on the therapies currently available for physical salivary stimulation in individuals with hyposalivation caused by radiotherapy. Study Design Studies were included when they comprised the target population of adult individuals receiving radiotherapy of the head and neck region and who developed or were at risk of developing hyposalivation. Two reviewers selected the studies and extracted data on the type of physical salivary ...
Tópico(s): Voice and Speech Disorders
2023 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology and Oral Radiology
Produção Nacional
Revisado por pares
Leticia M. Bezinelli, Luciana Corrêa, Stephany Beyerstedt, Marcella Liciani Franco, Érika Bevilaqua Rangel, Carlos Guillermo Benítez, Nelson Hamerschlak, João Renato Rebello Pinho, Débora Heller, Fernanda de Paula Eduardo,
Background Symptomatic patients with COVID-19 typically have a high SARS-CoV-2 viral load in their saliva. Procedures to reduce the viral load in their oral cavity are important for mitigating the viral transmission. Methods This randomized clinical trial investigated the impact of two mouthwashes (0.075% cetylpyridinium chloride plus 0.28% zinc lactate (CPC+Zn) ( n = 32), and 0.075% cetylpyridinium chloride (CPC) ( n = 31)) on the viral load of SARS-CoV-2 in saliva when compared to the distilled water negative ...
Tópico(s): Scientific and Engineering Research Topics
2023 - PeerJ, Inc. | PeerJ
Produção Nacional
Revisado por pares
Letícia Mello Bezinelli, Fernanda de Paula Eduardo, Danielle da Costa Palácio, Débora Heller, Danielle Viana Ribeiro Ramos, Denise de Fátima Barros Cavalcante, Mayra Torres Vasques, Paulo Francısco Cesar, Júlio César Martins Monte, Alexandre Holthausen Campos, Luciana Corrêa,
Distance between dentistry and medicine is a traditional and historical obstacle that affects multiple levels of the health system, especially the health policies to improve health service quality. Changes in dental education, especially involving the adoption of integrative health models in professional development, are considered essential for reducing this gap. We aimed to show a dental curriculum focused on special care as a tool for medicine-dentistry integration.In this study, we present a ...
Tópico(s): Dental Education, Practice, Research
2022 - Wiley | Special Care in Dentistry
Debora Kehl, Melanie Generali, Anna Mallone, Manfred Heller, Anne‐Christine Uldry, Phil F. Cheng, Benjamin Gantenbein, Simon P. Hoerstrup, Benedikt Weber,
Human mesenchymal stromal cell (hMSC) secretomes have shown to influence the microenvironment upon injury, promoting cytoprotection, angiogenesis, and tissue repair. The angiogenic potential is of particular interest for the treatment of ischemic diseases. Interestingly, hMSC secretomes isolated from different tissue sources have shown dissimilarities with respect to their angiogenic profile. This study compares angiogenesis of hMSC secretomes from adipose tissue (hADSCs), bone marrow (hBMSCs), and ...
Tópico(s): Proteoglycans and glycosaminoglycans research
2019 - Nature Portfolio | npj Regenerative Medicine