Valentina Battaglia, Anna Maria Brunati, Cristina Fiore, Carlo Rossi, Mauro Salvi, Elena Tibaldi, Mario Palermo, Decio Armanini, Antonio Toninello,
Glycyrrhetinic acid (GE), a hydrolysis product of glycyrrhizic acid, one of the main constituents of licorice root, is able, depending on its concentration, to prevent or to induce the mitochondrial permeability transition (MPT) (a phenomenon related to oxidative stress) in rat heart mitochondria (RHM). In RHM, below a threshold concentration of 7.5 μM, GE prevents oxidative stress and MPT induced by supraphysiological Ca2+ concentrations. Above this concentration, GE induces oxidative stress by interacting ...
Tópico(s): Phytochemistry and biological activity of medicinal plants
2007 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Biomembranes
Décio Krause, Antonio Mariano Nogueira Coelho,
The concept of indiscernibility in a structure is analysed with the aim of emphasizing that in asserting that two objects are indiscernible, it is useful to consider these objects as members of (the domain of) a structure. A case for this usefulness is presented by examining the consequences of this view to the philosophical discussion on identity and indiscernibility in quantum theory.
Tópico(s): Philosophy and History of Science
2005 - Springer Nature | Axiomathes
Mauro Salvi, Cristina Fiore, Valentina Battaglia, Mario Palermo, Decio Armanini, Antonio Toninello,
Carbenoxolone (Cbx), a derivative of glycyrrhetinic acid, which has been found to affect mineralocorticoid and glucocorticoid receptors, induces swelling and membrane potential collapse when added to Ca(2+)-loaded liver mitochondria at 10 microM concentrations. These effects are strictly correlated with hydrogen peroxide generation, increase in oxygen uptake, and sulfhydryl and pyridine nucleotide oxidation. Cyclosporin A, bongkrekic acid, and N-ethylmaleimide completely abolish all the above-described ...
Tópico(s): Metabolism and Genetic Disorders
2005 - Oxford University Press | Endocrinology
Cristina Fiore, Mauro Salvi, Mario Palermo, Giulietta Sinigaglia, Decio Armanini, Antonio Toninello,
Glycyrrhetinic acid (GE), the aglycone of glycyrrhizic acid, a triterpene glycoside which represents one of the main constituents of licorice root, induces an oxidative stress in liver mitochondria responsible for the induction of membrane permeability transition. In fact, GE, by interacting with the mitochondrial respiratory chain, generates hydrogen peroxide which in turn oxidizes critical thiol groups and endogenous pyridine nucleotides leading to the opening of the transition pore. Most likely ...
Tópico(s): Plant biochemistry and biosynthesis
2004 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Bioenergetics
Célia Regina Sousa da Silva, Roberto Palma dos Reis, Andreia Pereira, Sofia Borges, Ana Isabel Freitas, G Guerra, Sara Gouveia, Teresa Góis, Lino Nóbrega, Mariana Rodrigues, E Henriques, Sónia Freitas, Ilídio Ornelas, Décio Pereira, António Brehm, M I Mendonça,
Introdução: A hipertensão arterial é uma doença complexa, multifatorial, controlada por fatores genéticos e ambientais.Objetivo: Avaliar a susceptibilidade genética no aparecimento de hipertensão arterial e sua associação com os fatores de risco tradicionais na eclosão desta patologia.Material e Métodos: Estudo caso-controlo com 1712 indivíduos, idade média de 51,0 ± 7,9 anos (860 hipertensos e 852 controlos). Avaliaram-se os fatores tradicionais, bioquímicos e as variantes genéticas: ACE I/D rs4340, ...
Tópico(s): Nutrition, Genetics, and Disease
2018 - Ordem dos Médicos | Acta Médica Portuguesa
Cecilia Vicuña, Ernesto Livon-Grosman,
... German Belli, Francisco Madariaga, Leonidas Lamborghini, Godofredo Iommi, Decio Pignatari, Edgardo-Antonio Vigo, Enrique Lihn, Haroldo de Campos, Juan Gelman, ...
Tópico(s): Comparative Literary Analysis and Criticism
2010 - Association of College and Research Libraries | Choice Reviews Online
Mauro Salvi, Cristina Fiore, Decio Armanini, Antonio Toninello,
Glycyrrhetinic acid, a hydrolysis product of one of the main constituents of licorice, the triterpene glycoside of glycyrrhizic acid, when added to rat liver mitochondria at micromolar concentrations induces swelling, loss of membrane potential, pyridine nucleotide oxidation, and release of cytochrome c and apoptosis inducing factor. These changes are Ca(2+) dependent and are prevented by cyclosporin A, bongkrekic acid, and N-ethylmaleimide. All these observations indicate that glycyrrhetinic acid ...
Tópico(s): Chromatography in Natural Products
2003 - Elsevier BV | Biochemical Pharmacology
Fernando Marcuz Silva, Schlioma Zaterka, Jaime Natan Eisig, Ethel Zimberg Chehter, Décio Chinzon, Antônio Atílio Laudanna,
Triple therapy is accepted as the treatment of choice for H. pylori eradication. In industrialized countries, a proton pump inhibitor plus clarithromycin and amoxicillin or nitroimidazole have shown the best results. Our aims were: 1. To study the eradication rate of the association of a proton pump inhibitor plus tinidazole and clarithromycin on H. pylori infection in our population. 2. To determine if previous treatments, gender, age, tobacco, alcohol use, and non-steroidal anti-inflammatory drugs ( ...
Tópico(s): Gastroesophageal reflux and treatments
2001 - Universidade de São Paulo - FM/USP | Revista do Hospital das Clínicas
Produção Nacional
Leonardo Javier Arcuri, M. Schirmer, Marta Colares, Simone Maradei, Rita de Cássia Tavares, Maria Cláudia Rodrigues Moreira, Renato de Castro Araújo, Décio Lerner, Antônio Guilherme Pacheco,
Cytomegalovirus (CMV) reactivation remains one of the main infectious complications following hematopoietic stem cell transplantation (HSCT). In this study, we explored the role of anti-CMV antibody titers in HSCT from alternative donors and to compare the risk of CMV reactivation between posttransplant cyclophosphamide-based haploidentical HSCT and antithymocyte globulin-based unrelated donor (URD) HSCT. We included 98 CMV-positive patients, 30 undergoing haploidentical HSCT and 68 undergoing URD ...
Tópico(s): Herpesvirus Infections and Treatments
2020 - Elsevier BV | Biology of Blood and Marrow Transplantation
Produção Nacional
Revisado por pares
Alice Nardoni Marteli, Laís Vieira Genro, Décio Diament, Laurindo Antônio Guasselli,
RESUMO A leptospirose é um problema de saúde pública mundial. No Brasil, ela é uma doença de notificação compulsória e está relacionada a áreas com precárias condições sanitárias. Foi realizado um estudo ecológico retrospectivo para observar a distribuição espacial e temporal de casos confirmados da leptospirose em escala nacional no período entre 2007 e 2017. A espacialização da leptospirose utilizou técnicas de geoprocessamento por análise de padrões pontuais e por mapas de densidade Kernel. Os ...
Tópico(s): Leptospirosis research and findings
2020 - Centro Brasileiro de Estudos de Saúde | Saúde em Debate
Produção Nacional
Revisado por pares
Tarlliza R. Nardelli, Emerielle C. Vanzela, Keli Cristina Benedicto, Flora Brozzi, André Fujita, Alessandra K. Cardozo, Décio L. Eizirik, Antônio C. Boschero, Fernanda Ortis,
Type 1 diabetes is caused by an autoimmune assault that induces progressive beta-cell dysfunction and dead. Pro-inflammatory cytokines, such as interleukin 1 beta (IL1B), tumor necrosis factor (TNF) and interferon gamma (IFNG) contribute for beta-cell death, which involves the activation of the nuclear factor kappa B (NFκB) and c- Jun N-terminal kinase (JNK). Prolactin (PRL), a physiological mediator for beta-cell proliferation, was shown to protect beta cells against cytokines pro-apoptotic effects. ...
Tópico(s): Pancreatic function and diabetes
2018 - Bioscientifica | Journal of Molecular Endocrinology
Rui Póvoa, Weimar Kunz Sebba Barroso, Andréa Araújo Brandão, Paulo César Brandão Veiga Jardim, Oswaldo Barroso, Oswaldo Passarelli, João Roberto Gemelli, Audes D. M. Feitosa, Thiago Veiga Jardim, Sérgio Baiocchi Carneiro, Celso Amodeo, Osni Moreira Filho, Armando da Rocha Nogueira, Nelson Siqueira de Morais, Luiz César Nazário Scala, Carolina Gonzaga, Dilma do Socorro Moraes de Souza, Annelise Machado Gomes de Paiva, Marcus Vinícius Bolívar Malachias, Décio Mion, Marco Antônio Mota Gomes, Eduardo Costa Duarte Barbosa, Márcio Gonçalves de Sousa, Henrique Tria Bianco, Francisco Antônio Helfenstein Fonseca, Marcio Kalil, Roberto Dischinger Miranda, Carlos André Uehara, Antônio Felipe Sanjuliani,
Arterial hypertension (AH) is a highly prevalent disease, and is a major cardiovascular (CV) risk factor1; therefore, achieving blood pressure (BP) control goals as soon as possible is paramount to reduce that risk2. That means that approximately 70% of hypertensive individuals will need antihypertensive drug combination3, and up to 30% of hypertensive individuals are estimated to use four or more drugs to achieve BP control4. Thus, drug combination is currently described as an important strategy to ...
Tópico(s): Blood Pressure and Hypertension Studies
2014 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Décio Mion, Marco Antônio Mota Gomes, Fernando Nobre, Celso Amodeo, Osvaldo Kohlmann, José Nery Praxedes, Carlos Alberto Castellanos Machado, Carlos Alberto Castellanos Machado, I. Pascoal, Lucélia C. Magalhães,
controle em todo o país.
Tópico(s): Blood Pressure and Hypertension Studies
2004 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Décio Zylbersztajn, Cláudio Antônio Pinheiro Machado Filho,
Studies on competitiveness in agri‐food systems have been challenged by non‐standard approaches. Traditional studies are defined as the ones based on comparative costs and market participation of countries or industries. Since comparative costs and market shares are distorted by subsidies, especially for agricultural products, traditional approaches show inconsistent results. Discusses competitiveness in a dynamic way, based on comparative capacity of agribusiness chain co‐ordination. In order to ...
Tópico(s): Wine Industry and Tourism
2003 - Emerald Publishing Limited | Supply Chain Management An International Journal
Produção Nacional
Revisado por pares
Décio Auler, Walter Antônio Bazzo,
Neste artigo, situamos, inicialmente, o surgimento histórico do movimento ciência, tecnologia e sociedade (CTS). Por se tratar de um movimento que emerge em contextos bastante distintos do nosso, num segundo momento discutimos aspectos a serem considerados na configuração de seus objetivos no contexto educacional brasileiro, apontando limitações e desafios que se colocam. Destacamos a nossa inexperiência democrática, relacionada com a trajetória histórica do país, como um dos obstáculos/desafios ...
Tópico(s): Chemistry Education and Research
2001 - UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO | Ciência & Educação (Bauru)
Andreia Pereira, M I Mendonça, Célia Regina Sousa da Silva, Sofia Borges, Sónia Freitas, E Henriques, Mariana Figueiredo Rodrigues, Ana Isabel Freitas, G Guerra, Ilídio Ornelas, Décio Pereira, António Brehm, Roberto Palma dos Reis,
Several genetic risk scores (GRS) have been associated with cardiovascular disease; their role, however, in survival from proven coronary artery disease (CAD) have yielded conflicting results.The objective of this study was to evaluate long-term cardiovascular mortality according to the genetic risk score in a Southern European population with CAD.A cohort of 1464 CAD patients with angiographic proven CAD were followed up prospectively for up to 58.3 (interquartile range: 25.8-88.1) months. Genotyping ...
Tópico(s): Lipoproteins and Cardiovascular Health
2017 - Wiley | International Journal of Clinical Practice
Rufino Nascimento, Décio Pereira, António Drumond Freitas, Eva Campos Pereira, M I Mendonça, Martim Dinis,
Two-dimensional (2D) echocardiographic visual estimation of left ventricular (LV) ejection fraction (EF) in patients with acquired heart disease yields results that are comparable to those obtained by recommended algorithms. However, there is no information concerning its accuracy in congenital heart disease. This study compares applicability, accuracy, and reproducibility of LVEF by visual estimation with that by currently used algorithms (cylinder hemiellipsoid, ellipsoid biplane, and biplane method ...
Tópico(s): Cardiac Valve Diseases and Treatments
1997 - Elsevier BV | The American Journal of Cardiology
Produção Nacional
Décio Krause, Antônio Augusto Passos Videira,
This volume, The Brazilian Studies in the Philosophy and History of Science, is the first attempt to present to a general audience, works from Brazil on this subject. The included papers are original,
Tópico(s): Space Science and Extraterrestrial Life
2011 - Springer Nature | Boston studies in the philosophy of science
Andrea Leonardi, Decio Capobianco, Nicola Benedetti, Antonio Capobianco, Fabiano Cavarzeran, Tania Scalora, Rocco Luigi Modugno, Oren Mark Feuerman,
Purpose: To study the tolerability and efficacy of two formulations of topical ketotifen ophthalmic solutions for the treatment of seasonal allergic conjunctivitis (SAC).Methods: 81 active SAC patients were treated with either ketotifen 0.025% or 0.05% eye drops for 3 weeks. Allergic signs and symptoms were evaluated at baseline (V0), after 7 (V1) and 21 days (V2). Drugs tolerability and ratings of global efficacy were recorded.Results: Both concentrations of ketotifen were highly effective. The total ...
Tópico(s): Food Allergy and Anaphylaxis Research
2018 - Taylor & Francis | Ocular Immunology and Inflammation
Andreia Pereira, M I Mendonça, Sofia Borges, Célia Regina Sousa da Silva, Sónia Freitas, E Henriques, Mariana Figueiredo Rodrigues, Ana Isabel Freitas, G Guerra, Carolina Freitas, Décio Pereira, António Brehm, Roberto Palma dos Reis,
The utility of genetic risk scores (GRS) as independent risk predictors remains inconclusive. Here, we evaluate the additive value of a multi-locus GRS to the Framingham risk score (FRS) in coronary artery disease (CAD) risk prediction. A total of 2888 individuals (1566 coronary patients and 1322 controls) were divided into three subgroups according to FRS. Multiplicative GRS was determined for 32 genetic variants associated to CAD. Logistic Regression and Area Under the Curve (AUC) were determined first, ...
Tópico(s): Cardiovascular Function and Risk Factors
2018 - Brazilian Society of Genetics | Genetics and Molecular Biology
João Mattar, William C. Shoemaker, Décio Diament, André V. Lomar, ANTONIO C. LOPES, EDSON DE FREITAS, FRANCISCO P. STELLA, LUIZ A. P. FACTORE,
The waveform of the first derivative of thoracic electrical bioimpedance was used to calculate systolic time intervals of the cardiac cycle, preejection period/left ventricular ejection time ratio, and diastolic time intervals, isovolumic relaxation period/filling time ratio.Prospective clinical study. Waveforms were examined from 913 normal and abnormal tracings from a thoracic electrical bioimpedance monitor. This monitor was coupled to a two-channel strip-chart recorder that identified preejection ...
Tópico(s): Healthcare Technology and Patient Monitoring
1991 - Lippincott Williams & Wilkins | Critical Care Medicine
Produção Nacional
Cristiano Roberto Grimaldi Barcellos, Michelle P. Rocha, Sylvia Asaka Yamashita Hayashida, Décio Mion, Silvia G. Lage, José Antônio Miguel Marcondes,
As there is controversy about the prevalence of hypertension in patients with polycystic ovary syndrome (PCOS) and, up to the present moment, no studies have evaluated the impact of body mass index (BMI) on blood pressure levels (BP) in these patients, we studied retrospectively sixty-nine patients with PCOS, with BMI of 29.0 +/- 6.7 kg/m(2) and aged 25.6 +/-5.6 yr, subdivided into three groups according to BMI (normal, overweight and obese) and evaluated regarding BP (mercury sphygmomanometer), basal hormonal ...
Tópico(s): Liver Disease Diagnosis and Treatment
2007 - Editora da Universidade de São Paulo | Arquivos Brasileiros de Endocrinologia & Metabologia
Décio Mion, Kátia Coelho Ortega, Marco Antônio Mota Gomes, Osvaldo Kohlmann, Wille Oigman, Fernando Nobre,
Objectives The use of low-dose amlodipine has not yet been well established in the elderly. This study therefore aimed to evaluate the efficacy and tolerability of low-dose amlodipine in elderly patients with Joint National Committee VI stage I or II hypertension. Patients and methods Sixty-five hypertensive individuals (aged 66.3±5.3 years) received amlodipine 2.5 mg per day for 12 weeks before and after two periods of 4 weeks of placebo. At weeks 0, 12 and 16, patients were submitted to office, ...
Tópico(s): Cardiovascular Syncope and Autonomic Disorders
2004 - Lippincott Williams & Wilkins | Blood Pressure Monitoring
Célia Regina Sousa da Silva, Roberto Palma dos Reis, Andreia Pereira, Sofia Borges, Ana Isabel Freitas, G Guerra, Teresa Góis, Mariana Rodrigues, E Henriques, Sónia Freitas, Ilídio Ornelas, Décio Pereira, António Brehm, M I Mendonça,
Essential hypertension (EH) is a complex disease in which physiological, environmental, and genetic factors are involved in its genesis. The genetic variant of the alpha-adducin gene (ADD1) has been described as a risk factor for EH, but with controversial results. The objective of this study was to evaluate the association of ADD1 (Gly460Trp) gene polymorphism with the EH risk in a population from Madeira Island. A case-control study with 1614 individuals of Caucasian origin was performed, including ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2017 - Wolters Kluwer | Medicine
Produção Nacional
Revisado por pares
Osvaldo Kohlmann, Wille Oigman, Décio Mion, João Carlos da Rocha, Marco Antônio Mota Gomes, Natalino Salgado, Gílson Soares Feitosa, Ernesto Dallaverde, Artur Beltrame Ribeiro,
OBJETIVO: O estudo LOTHAR avaliou a eficácia, tolerabilidade e os efeitos metabólicos em médio e longo prazo (um ano) da combinação fixa de anlodipino e losartana versus anlodipino e losartana isoladamente. MÉTODOS: Estudo multicêntrico brasileiro, randomizado, duplo-cego e comparativo realizado com 198 pacientes com hipertensão arterial primária em estágios 1 e 2. RESULTADOS: A combinação fixa apresenta alta eficácia anti-hipertensiva que se mantém em longo prazo com percentual reduzido de escape ...
Tópico(s): Cardiovascular Syncope and Autonomic Disorders
2006 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Vanessa Zambelli, Giacomo Bellani, Roberto Borsa, Federico Pozzi, Alice Grassi, Margherita Scanziani, Vittoria Castiglioni, Serge Masson, Alessandra Decio, John G. Laffey, Roberto Latini, Antonio Pesenti,
The renin-angiotensin system (RAS) plays a role in the pathogenesis of ARDS, Angiotensin II (Ang-II) contributing to the pathogenesis of inflammation and fibrogenesis. Angiotensin-(1-7) (Ang-(1-7)) may antagonize the effects of Ang-II. This study was aimed at evaluating the potential for Ang-(1-7) to reduce injury, inflammation and fibrosis in an experimental model of ARDS in the acute and late phases.Male Sprague Dawley rats underwent an instillation of 0.1 M hydrochloric acid (HCl, 2.5 ml/kg) into ...
Tópico(s): Heart Failure Treatment and Management
2015 - Springer Nature | Intensive Care Medicine Experimental
Produção Nacional
Revisado por pares
Aladim Gomes Lameira, Flávia Sirotheau Corrêa Pontes, Douglas Magno Guimarães, Ana Carolina Garcia Alves, Adriana Souza de Jesus, Hélder Antônio Rebelo Pontes, Décio dos Santos Pinto Júnior,
The aim of this study was to identify the expression of MCM3, Ki-67 and p27 in normal mucosa, leucoplakia and oral squamous cell carcinoma (OSCC) and determine whether altered expression could serve as a prognostic marker of a malignant progression of dysplastic lesions.The samples were collected from 37 patients with oral leucoplakia (13 with mild dysplasia - MLD, 12 with moderate dysplasia - MD and 12 with severe dysplasia - SD). Eleven samples of mouth floor mucocele (M) and 50 floor mouth and tongue ...
Tópico(s): Salivary Gland Tumors Diagnosis and Treatment
2014 - Wiley | Journal of Oral Pathology and Medicine
Produção Nacional
Revisado por pares
Brunno Santos de Freitas Silva, Fernanda Paula Yamamoto‐Silva, Hélder Antônio Rebelo Pontes, Décio dos Santos Pinto Júnior,
There is some evidence of Twist participation in oral carcinogenesis; however, little is known about its interaction with E-cadherin in oral squamous cell carcinoma (OSCC) development. This experimental study included an immunohistochemical analysis of Twist and E-cadherin proteins in paraffin-embedded specimens of oral leukoplakia (OL), OSCC, and normal oral mucosa. In addition, it was also performed a Western blot and double-immunofluorescence analysis of Twist and E-cadherin expression in OSCC ...
Tópico(s): Hedgehog Signaling Pathway Studies
2013 - Wiley | Journal of Oral Pathology and Medicine
Produção Nacional
Revisado por pares
Flávia Sirotheau Corrêa Pontes, José Thiers Carneiro, Felipe Paiva Fonseca, Taíse Sousa Pamplona da Silva, Hélder Antônio Rebelo Pontes, Décio dos Santos Pinto Júnior,
Oral squamous cell carcinoma (OSCC) accounts for more than 95% of all malignant neoplasms in the oral cavity. Although several studies have shown the epidemiology of this cancer in Brazil, there do not seem to be any studies that describe the prognostic factors related to OSCC in the Amazon region. Therefore, the aim of this study was to determine the survival rate and prognostic significance of different factors in patients from this region affected by OSCC. Data from 85 patients with histologically ...
Tópico(s): Oral health in cancer treatment
2011 - Lippincott Williams & Wilkins | Journal of Craniofacial Surgery
Produção Nacional
Revisado por pares
E M Krieger, Luciano F. Drager, D Giorgi, Alexandre C. Pereira, José Augusto Barreto‐Filho, Armando R. Nogueira, José Geraldo Mill, Paulo A. Lotufo, Celso Amodeo, Marcelo C. Batista, Luiz Carlos Bodanese, Antonio C.C Carvalho, Iran Castro, Hilton Chaves, Eduardo A. Costa, Gílson Soares Feitosa, Roberto Jorge da Silva Franco, Flávio Danni Fuchs, Armênio Costa Guimarães, Paulo César Brandão Veiga Jardim, Carlos Alberto Machado, Maria Eliane Campos Magalhães, Décio Mion, Raimundo Marques Nascimento, Fernando Nobre, Antônio Cláudio Lucas da Nóbrega, Antônio Luiz Pinho Ribeiro, Carlos R.M. Rodrigues‐Sobrinho, Antônio Felipe Sanjuliani, Maria do Carmo Borges Teixeira, José Eduardo Krieger, Alessandro Betito, Diogo D.F. Moia, Silvia Beatriz Paulino Cavasin de Souza, Hilton de Castro Chaves Júnior,
The aim of this study is to compare spironolactone versus clonidine as the fourth drug in patients with resistant hypertension in a multicenter, randomized trial. Medical therapy adherence was checked by pill counting. Patients with resistant hypertension (no office and ambulatory blood pressure [BP] monitoring control, despite treatment with 3 drugs, including a diuretic, for 12 weeks) were randomized to an additional 12-week treatment with spironolactone (12.5–50 mg QD) or clonidine (0.1–0.3 mg BID). ...
Tópico(s): Cardiovascular Syncope and Autonomic Disorders
2018 - Lippincott Williams & Wilkins | Hypertension