National Bureau of Economic Research (NBER)
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... 9am) Film choice Regional Variations Satellite Radio A Dmn Good Lie (Sunday, R1,9pm) Radio World Service ...
1992 - Gale Group | Sunday Times HA GDA
Herbert S. Rosenkranz, Samuel Rosenkranz, Robert M. Schmidt,
The relationship between microsomal dimethylnitrosamine (DMN) demethylase activity and the capacity of isolated hepatic microsomes to activate DMN to a mutagen was examined using microsomes from C57 ... which appears to induce both types of cytochromes. DMN induced mutagenesis was assayed by a Salmonella auxotroph ... three inducers increased both the activity of microsomal DMN demethylase and the capacity of the microsomes to activate DMN mutagenicity. In each case, however, the increase in mutagenicity was disproportionately greater than the increase in DMN demethylase activity. This was particularly evident with microsomes ...
Tópico(s): Molecular Sensors and Ion Detection
1969 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis
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... Resources Maplin Electronics Lotus Group CTC Marine Projects DMN Installations Oscar Mayer Towergate Underwriting Strata Group Boden ...
2004 - Gale Group | Sunday Times HA GDA
I.G. Sipes, Marguerite Lenore Slocumb, Golde I. Holtzman,
... vivo microsomal enzyme modifiers and in vitro dimethylnitrosamine (DMN) metabolism, male C57BL/6J mice were pretreated with ... or Aroclor 1254, two compounds known to influence DMN-N-demethylase activity. Pretreatment with acetone enhanced the in vitro microsomal activity of DMN-N-demethylase, as measured by formaldehyde production from DMN. Accompanying this acetone-enhanced demethylase activity was an increase in the covalent binding of [14C] DMN to RNA, protein, and DNA. Four distinct Km ... lowest Km observed in the control microsomes. At DMN concentrations of 1 and 10 mM, acetone significantly ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
1978 - Elsevier BV | Chemico-Biological Interactions
Richard Kvetn ̃anský, Irwin J. Kopin, Juan M. Saavedra,
The hypothalamic dorsomedial nucleus (DMN) represents an important coordinate center for regulation of autonomic and neuroendocrine systems, especially during stress response. The present study was ... and the protein levels of tyrosine hydroxylase in DMN, both in control and stressed rats. Moreover, pathways modulating the gene expression of tyrosine hydroxylase in DMN during immobilization (IMO) stress were also investigated. Gene ... of all catecholamine-synthesizing enzymes were detected in DMN samples. While the levels of tyrosine hydroxylase and ...
Tópico(s): Neuroscience of respiration and sleep
1978 - Elsevier BV | Brain Research
John C. Phillips, Brian G. Lake, S.D. Gangolli, P. Grasso, Alun G. Lloyd,
... alcohol metabolism, profoundly inhibited the metabolism of dimethylnitrosamine (DMN), both in terms of [14C]CO2 excretion and ... disulfiram), methanol, and ethanol inhibited the metabolism of DMN in the whole animal. In parallel experiments with [ ... pretreatment on the acute toxicity and hepatotoxicity of DMN showed that pyrazole significantly increased the median lethal dose (LD50) of DMN and provided substantial protection against the hepatotoxicity of DMN, in that centriblobular necrosis was not seen at ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
1977 - Oxford University Press | JNCI Journal of the National Cancer Institute
SEWA R. JOSHI, Jerry M. Rice, Martin L. Wenk, Peter P. Roller, Larry K. Keefer,
Methyl(acetoxymethyl)nitrosamine (DMN-OAc) was synthesized and tested for toxicity and carcinogenicity in rats to test the hypothesis that alpha-hydroxylation is required for metabolic activation of dimethylnitrosamine (DMN) to a reactive, proximate carcinogen. The acute median lethal doses (LD50) of DMN-OAc and DMN injected ip into 5-week-old male Sprague- ... 59 mmole/kg body weight or 25 mg DMN-OAc/kg and 44 mg DMN/kg body weight, respectively. Single ip injections of one-half the LD50 DMN-OAc (13 mg/kg body weight) in 5- ...
Tópico(s): Diet, Metabolism, and Disease
1977 - Oxford University Press | JNCI Journal of the National Cancer Institute
Joseph B. Guttenplan, Ferenc Hutterer, Anthony J. Garro,
The relationship between microsomal dimethylnitrosamine (DMN) demethylase activity and the capacity of isolated hepatic microsomes to activate DMN to a mutagen was examined using microsomes from C57 ... which appears to induce both types of cytochromes. DMN induced mutagenesis was assayed by a Salmonella auxotroph ... three inducers increased both the activity of microsomal DMN demethylase and the capacity of the microsomes to activate DMN mutagenicity. In each case, however, the increase in mutagenicity was disproportionately greater than the increase in DMN demethylase activity. This was particularly evident with microsomes ...
Tópico(s): Alcohol Consumption and Health Effects
1976 - Elsevier BV | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
... overview of work involving the dorsomedial hypothalamic nucleus (DMN). This structure is located dorsal to the ventromedial ... of the dorsal premammillary nucleus. Fibers from the DMN pass with the periventricular system and the dorsal ... reticular formation. Intrahypothalamic connections involve intensive networks between DMN, lateral hypothalamic nucleus (LHN) and VMN. Regarding neurotransmitters, recent studies indicate that the DMN receives noradrenergic innervation along two pathways, a dorsal ... a ventral one. Monoamine-containing systems approach the DMN from the lateral hypothalamus and the bulk of ...
Tópico(s): Neonatal Respiratory Health Research
1975 - Cambridge University Press | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Steven Michael Haag, I.G. Sipes,
... acetone enhances the microsomal N-demethylation of dimethylnitrosamine (DMN) at low substrate concentrations (< 5 mM), while pretreatment ... low, but enhances it at high (> 35 mM) DMN concentrations. To relate the activity of DMN demethylase with the mutagenicity of DMN, liver microsomes were isolated aseptically from mice 18 ... incubated with S. typhimurium (TA 1535), NADPH and DMN (1, 3 or 70 mM) for 5 to ... were determined. Microsomes from acetone pretreated mice bioactivated DMN to a mutagen at significantly higher (p < 0. ...
Tópico(s): Carcinogens and Genotoxicity Assessment
1980 - Elsevier BV | Mutation Research/Environmental Mutagenesis and Related Subjects
William W. Carlton, Peggy S. Price,
... deficient and excess-copper diets and given dimethylnitrosamine (DMN) in the drinking-water for 9 months. The ... highest mortality (72%) occurred in the excess-copper-DMN group. Liver weights were increased in the AAF- ... greater than that found in hepatic tissue from DMN-treated (3·9 ppm) or AAF-fed rats ( ... in controls, while the comparable figures for the DMN-treated and AAF-fed rats were 394 and ... The incidence of hepatic neoplasms was similar in DMN-treated rats fed either the copper-deficient or ... 57 % of the rats receiving the copper-deficient-DMN treatment and killed for autopsy, compared to an ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
1973 - Elsevier BV | Food and Cosmetics Toxicology
D.Y. Lai, Stephen C. Myers, Yin‐tak Woo, Elliott J. Greene, Marvin A. Friedman, Mary F. Argus, J. C. Arcos,
... hepatic microsome-catalyzed in vitro binding of dimethylnitrosamine (DMN) to DNA. This parallels their effect on DMN-demethylase I, regarded to be the sole activating step in DMN carcinogenesis and fails to account for the previously ... while beta-NF enhances, the hepatocarcinogenic activity of DMN. The in vitro binding of DMN is clearly dependent on microsomes and NADPH, and ... In mice beta-NF enhances and PCN inhibits DMN-demethylase I; beta-NF has no effect on ... in mice on the host-mediated mutagenicity of DMN in a dose-response study, except for the ...
Tópico(s): Aldose Reductase and Taurine
1979 - Elsevier BV | Chemico-Biological Interactions
R. B. Veazey, Charles M. Severin,
Afferent projections to the deep mesencephalic nucleus (DMN) of the rat were demonstrated with axonal transport techniques. Potential sources for projections to the DMN were first identified by injecting the nucleus with ... radioisotope, the tissue processed for autoradiography, and the DMN examined for anterograde labeling. Afferent projections to the medial and/or lateral parts of the DMN were found to originate from a number of ... to both medial and lateral parts of the DMN include the ipsilateral motor and somatosensory cortex, the ...
Tópico(s): Axon Guidance and Neuronal Signaling
1982 - Wiley | The Journal of Comparative Neurology
L.C. Waters, C.R. Nix, J.L. Epler,
The relationship between dimethylnitrosamine (DMN) demethylase activity and DMN-induccd mutagenesis was investigated in Drosophila metanogaster. The activity of DMN-demethylase was at least 10-fold greater in ... sex-linked recessive lethal (SLRL) mutations induced by DMN in the four strains differed by less than ... possibilities to explain the lack of correlation between DMN-demethylase activity and DMN-induced mutations were tested and eliminated. They include: (i) the presence of inhibitors of DMN-demethylase in extracts of low-activity strains, (ii) ...
Tópico(s): Glutathione Transferases and Polymorphisms
1983 - Elsevier BV | Chemico-Biological Interactions
Scherer S. Duke, Lawrence B. Schook, Michael P. Holsapple,
Abstract Dimethylnitrosamine (DMN) exposure altered the activity of the macrophage and natural killer (NK) cell defense mechanisms against the B16F10 melanoma ... 1.5, 3.0, or 5.0 mg DMN/kg, mice were injected (i.v.) with B16F10 ... 18 days after challenge, were decreased in the DMN-exposed animals. The initial observation indicated the mice exposed to 3 mg/kg DMN were afforded the greatest protection. However, when mice exposed to the highest dose of DMN were divided into subgroups of mice with or ... frequently associated with exposure to 5 mg/kg DMN. Exposure to DMN produced only slight changes in ...
Tópico(s): Chemical Reactions and Isotopes
1985 - Oxford University Press | Journal of Leukocyte Biology
Edward A. Fox, Terry L. Powley,
... within the dorsal motor nucleus of the vagus (DMN). The columns representing the 4 branches with the ... distributions on either side of the medulla. Each DMN side contains a column occupying the medial two- ... corresponding to one of the gastric branches (left DMN, anterior gastric; right DMN, posterior gastric). Also on each side, the lateral pole of the DMN consists of a coherent cell column corresponding to one of the celiac branches (left DMN, accessory celiac; right DMN, celiac). The fifth branch, the hepatic, is represented ...
Tópico(s): Neuroscience of respiration and sleep
1985 - Elsevier BV | Brain Research
Joseph W. Gunnet, Marc E. Freeman,
... preoptic area (MPOA) and the dorsomedial-ventromedial nuclei (DMN-VMN) of the hypothalamus regulate the mating-induced ... the MPOA serves an inhibitory role while the DMN-VMN serves a stimulatory role. The diurnal surge ... of functional interactions between the MPOA and the DMN-VMN in control of mating-induced prolactin secretion. ... inhibitory effects of the MPOA operate through the DMN-VMN, electrical stimulation was applied to the MPOA ... female rats bearing bilateral electrolytic lesions of the DMN-VMN. In the first experiment, control (sham-stimulated, ...
Tópico(s): Hypothalamic control of reproductive hormones
1985 - Karger Publishers | Neuroendocrinology
... typhimurium TA100 were treated with the precarcinogens dimethylnitrosamine (DMN) or diethylnitrosamine (DEN) in the presence of S9 ... V79 cells and His+ revertants in TA100 resulted. DMN was a far more efficient SCE inducer than ... a more efficient inducer of His+ revertants than DMN. Retinol (Rol) effectively inhibited DMN and DEN induced SCE in V79 cells and ... Rol at various doses and one dose of DMN or DEN in the presence of S9 mix ... of SCE as compared to SCE induced by DMN or DEN without Rol. Rol inhibition of DMN- ...
Tópico(s): Folate and B Vitamins Research
1987 - Elsevier BV | Mutation Research/Genetic Toxicology
Michael J. Myers, Cathy S. Dickens, Lawrence B. Schook,
Dimethylnitrosamine (DMN), a potent immunomodulatory agent, produces its effects on cell-mediated immune reactions through alterations in macrophage production ... culture of bone marrow from animals exposed to DMN in vivo (bone marrow-derived macrophages, BMDM) demonstrated ... parvum-elicited peritoneal exudate cells (PEC) obtained from DMN-exposed animals while thioglycollate-elicited PEC from DMN-exposed animals displayed no increase in their cytotoxic ... gamma induced cytotoxic activity in PEC obtained from DMN-exposed animals but not in PEC obtained from ...
Tópico(s): Inflammatory mediators and NSAID effects
1987 - Elsevier BV | Immunopharmacology
Kirk W. Johnson, Dong‐Hyun Kim, Albert E. Munson, Michael P. Holsapple,
The in vitro activation of dimethylnitrosamine (DMN) to an immunosuppressive form was studied utilizing liver-enzyme fractions and intact hepatocytes. The N-demethylation of DMN by mouse S9 and microsome preparations was confirmed ... cells, neither S9 preparation was capable of activating DMN to a form capable of suppressing antibody responses ... markedly immunosuppressive form. S9 fractions failed to activate DMN to an immunosuppressive form regardless of S9 concentration, ... than S9 fractions yet were unable to activate DMN to an immunosuppressive form. In contrast, the addition ...
Tópico(s): Mast cells and histamine
1987 - Elsevier BV | Mutation Research/Environmental Mutagenesis and Related Subjects
Kirk W. Johnson, Albert E. Munson, Michael P. Holsapple,
... the cellular targets responsible for immunosuppression by dimethylnitrosamine (DMN). The in vitro antibody responses of splenocytes from B6C3F1 mice exposed to 6 mg/kg DMN for 7 days to the T cell-independent ... antibody-forming cell response of spleen cells from DMN-treated mice to the T-independent and T- ... cells after 3 h. By combining vehicle and DMN nonadherent and adherent populations it was demonstrated that the population most affected by DMN exposure in both the sheep erythrocyte and dinitrophenyl- ...
Tópico(s): Influenza Virus Research Studies
1987 - Elsevier BV | Immunopharmacology
Kim Dong-Hyun, Kyu‐Hwan Yang, Kirk W. Johnson, Michael P. Holsapple,
The metabolism and subsequent immunosuppressive effects of dimethylnitrosamine (DMN) were investigated in mixed cultures of mouse hepatocytes and mouse splenocytes. Hepatocytes were shown to activate DMN to an immunosuppressive form that caused the suppression ... SRBC). A significant increase in the binding of DMN metabolites to trichloroacetic acid (TCA) precipitable material in splenocytes was induced when 94 μM [14C-methyl]DMN was added to the co-culture medium, indicating that reactive intermediates of DMN were transferred from hepatocytes to splenocytes and resulted ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
1988 - Elsevier BV | Biochemical Pharmacology