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... thirst for another Double Ryan Giggs wears Reebok DMX The Times FA Cup romance an increasingly rare ...
1999 - Gale Group | TDA
Background: Depressive mixed state (DMX) is understudied, although this diagnostic concept may be of clinical and theoretical importance. Our goal was to provide preliminary evidence of the inter-episode stability of DMX. The inter-episode stability is known to be ... patient. Results: The inter-episode stability of categorical DMX diagnoses and the number of intra-episode manic ... but significantly high. Approximately 50% of patients with DMX in the index episode obtained a DMX diagnosis in the second episode. Approximately 40% of ...
Tópico(s): Schizophrenia research and treatment
2003 - Elsevier BV | Journal of Affective Disorders
Minoru Takeshima, Tatsuru Kitamura, Maki Kitamura, Tomokazu Kidani, Shin-ichi Tochimoto, F. Muramori, Kosaka Kazuto, Mitsuru Hasegawa, Katsuhiko Ueno, Syouni Hamahara, Kouichi Kurata,
Depressive mixed state (DMX) has been reported to be one of the most useful clinical markers for bipolar II disorder (BP-II) in the outpatient setting. However, the significance of DMX in emergency psychiatry has not been well studied. ... these, 34 were diagnosed as having BP-II. DMX was observed in 56 (40.3%) patients at ... patients who later developed bipolar disorder had experienced DMX (59.5% vs. 32.0%, p = 0.0044). In multivariate analysis, DMX was one of the independent predictors of conversion ... p = 0.037), and the independent predictors for DMX were chronic depression and atypical features (OR 2. ...
Tópico(s): Schizophrenia research and treatment
2008 - Elsevier BV | Journal of Affective Disorders
... bipolar II disorder (BP-II). Depressive mixed state (DMX), a major depressive episode (MDE) mixed with intra- ... the impact of temperamental mood lability (TML) on DMX.Consecutive 148 BP-II and 117 MDD outpatients ... major mood episodes since young age) were followed.DMX was present in 61.5%, TML in 52.8%. In the DMX sample, TML was present in 57.6%, and in the non-DMX sample TML was present in 45.0% (OR = ... 95% CI = 1.0-2.7). In the DMX sample, independent predictors of DMX with TML were BP-II and young age ... and atypical symptoms were not significantly different between DMX patients with TML and DMX patients without TML, ...
Tópico(s): Treatment of Major Depression
2005 - Karger Publishers | Psychopathology
Hue Minh Thi Nguyen, Gopinadhanpillai Gopakumar, Jozef Peeters, Minh Tho Nguyen,
... structure of the parent 5-dehydro-m-xylylene (DMX, or 5-dehydro-1,3-quinodimethane, C8H7) triradical ... an unpaired electron and its 4,6-dinitrogen (DMX-N) and 4,6-diphosphorus (DMX-P) derivatives. The purpose of the study is ... d,p) basis set reveal the following: (i) DMX has a three-open-shell (σ1π1π1) doublet 2B2 ... mol, and (ii) the ground state of both DMX-N and DMX-P triradicals is also the doublet 2B2 being ... violating Hund's rule. Protonation at C5 of DMX giving the MX•+ radical cation modifies the electronic ...
Tópico(s): Free Radicals and Antioxidants
2004 - American Chemical Society | The Journal of Physical Chemistry A
Franco Benazzi, Hagop S. Akiskal,
... specific parameters of bipolarity and depressive mixed state (DMX). Consecutive 348 bipolar-II (BP-II) and 254 ... features of hostility and anger. Depressive mixed state (DMX) was defined as a major depressive episode (MDE) ... of axis I comorbidity, atypical depressive features, and DMX. Upon logistic regression, we found a significant independent association between BP-II MDE with irritability and DMX. In UP, MDE with, versus without, irritability had ... age at onset, higher rates of atypical depression, DMX, and bipolar family history. Logistic regression revealed a ...
Tópico(s): Treatment of Major Depression
2004 - Elsevier BV | Journal of Affective Disorders
Depressive mixed state (DMX), i.e., a combination of hypomanic and depressive symptoms during the same episode, has recently seen a rebirth of ... description. Kraepelin observed, in an inpatient sample, that DMX was related to the number of episodes and ... systematically assessed in patients while off psychoactive drugs. DMX was dimensionally defined, following Akiskal and Benazzi (2003), ... more combined hypomanic symptoms. Kraepelin's examples of DMX, i.e., agitated depression (MDE plus psychomotor agitation) ...
Tópico(s): Electroconvulsive Therapy Studies
2004 - Karger Publishers | Psychopathology
Hotaka Shinzato, Munenaga Koda, A. Nakamura, Tsuyoshi Kondo,
... the prevalence and severity of depressive mixed state (DMX). Thus, we have developed a new scale for screening and quantification of DMX and examined the symptomatological structure and severity of DMX in individuals with major depressive episode (MDE).Subjects ... the self-administered 12-item questionnaire to assess DMX (DMX-12), together with the Quick Inventory of Depressive ... to each participant. The symptomatological structure of the DMX-12 was examined by exploratory factor analysis. Multiple ... were used to analyze factors contributing to the DMX-12 scale. The relationships of this scale with ...
Tópico(s): Tryptophan and brain disorders
2019 - Dove Medical Press | Neuropsychiatric Disease and Treatment
Recent studies showed that depressive mixed state (DMX) (major depressive episode [MDE] with few hypomanic symptoms) was common among depressed outpatients. The aim of the present study was to find a clinicallly useful definition of DMX. A useful definition could be one increasing the ... correct diagnosis of bipolar II. Different definitions of DMX were tested by comparing the sensitivity, specificity, and ... Structured Clinical Interview-Clinician Version (SCID-CV). Different DMX definitions were tested, based on factor analysis, multivariate ...
Tópico(s): Stuttering Research and Treatment
2003 - Elsevier BV | Comprehensive Psychiatry
Tetsuya Sato, Ronald Bottlender, Marcus Sievers, Hans‐Jürgen Möller,
... nature of unipolar depression with depressive mixed states (DMX) needs further validation studies. The seasonality of depressive ... of depressive episodes in unipolar depressive patients with DMX.The subjects were 958 consecutive depressive inpatients for a 6-year period. For defining DMX, previously validated operational criteria were used (2 or ... unipolar depressive patients with (N = 77) and without DMX (N = 786) separately. An appropriate statistic was used ... in spring was recognized in unipolar depression without DMX, while both bipolar depression and unipolar depression with ...
Tópico(s): Electroconvulsive Therapy Studies
2005 - Elsevier BV | Journal of Affective Disorders
... a rebirth of studies on depressive mixed state (DMX), defined as a major depressive episode (MDE) plus ... It is still unclear how to best define DMX. The study's aim was to test a categorical versus a dimensional definition of DMX.Consecutive 260 bipolar II disorder and 173 unipolar ... HIG). Different cutoffs of the HIG to define DMX were tested versus a categorical definition of DMX (requiring more than two concurrent hypomanic symptoms, DMX3). ... II diagnosis were compared. The best definition of DMX based on the HIG was also compared to ...
Tópico(s): Neurological disorders and treatments
2003 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Ildikó Klemmer, Shintaro Yagi, O Gressner,
... signaling by paraxanthine (1,7‐dimethylxanthine [1,7‐DMX]), the demethylated primary metabolite of caffeine Methods: Twenty ... operated with or without concomitant oral 1,7‐DMX (1 mM) application. Serum was investigated by standard ... vitro 50% inhibitory dose (ID50) of 1,7‐DMX was 0.95 mM by for CTGF promoter ... for protein expression in HSC. Oral 1,7‐DMX application (1 mM) attenuated cholestatic hepatocellular injury in ... Smad2/3 and CTGF following oral 1,7‐DMX intake. However, serum CTGF concentrations were not reduced ...
Tópico(s): Liver Disease Diagnosis and Treatment
2011 - Wiley | Hepatology Research
Christiane Kraemer, Bernd Weil, Markus Christmann, Erwin R. Schmidt,
DmX is a novel gene from Drosophila melanogaster located on the X chromosome in region 5D5/6- ... analysis of the genomic and cDNA sequences of DmX shows that the gene spans appr. 16 kb ... structure with 15 exons. The 12 kb long DmX transcript is present in Drosophila embryos, larvae and ... of both sexes. The open reading frame of DmX encodes a novel WD-repeat protein, containing at ... the dipeptide Trp–Asp (WD). Homologues of the DmX gene exist in other dipteran species, in Caenorhabditis elegans and human, revealing that DmX is an evolutionarily well conserved gene. The inferred ...
Tópico(s): Plant Molecular Biology Research
1998 - Elsevier BV | Gene
Cinthia García-Luna, Graciela Sanchez‐Watts, Myrtha Arnold, Guillaume de Lartigue, Nick DeWalt, Wolfgang Langhans, Alan G. Watts,
... in the dorsal motor nucleus of the vagus (DMX) and the nucleus of the solitary tract (NTS). ... the medulla, cholinergic preganglionic parasympathetic neurons in the DMX were virtually the only targets of chemosensory information ... on H129-infected somata and dendrites in the DMX, and on H129-infected DMX dendrites that extend into the NTS. Sensory transmission ... spinal routes from the PMV wall therefore reaches DMX neurons via axo-somatic appositions in the DMX and axo-dendritic appositions in the NTS. However, ...
Tópico(s): Cannabis and Cannabinoid Research
2021 - Society for Neuroscience | eNeuro
Maaike te Lintel Hekkert, Gary Newton, Kathryn Chapman, Rehan Aqil, Robert Downham, Robert Yan, Daphne Merkus, Gavin A. Whitlock, Charlotte A. L. Lane, Darren Cawkill, Trevor R. Perrior, Dirk J. Duncker, Michael Schneider,
... mechanisms for cardiomyocyte death remains an elusive goal. DMX-5804, a selective inhibitor of the stress-activated ... to strengthen the route to clinical success. Here, DMX-10001, a soluble, rapidly cleaved pro-drug of DMX-5804, was developed for i.v. testing in ... defined criteria, death before infusion, or technical issues. DMX-10001 was begun 20 min before reperfusion (30 ... beginning 30 min after the start of infusion, DMX-5804 concentrations exceeded > fivefold the levels that rescued ... reduced IS in mice after oral dosing with DMX-5804 itself. No significant reduction occurred in IS ...
Tópico(s): Neuroscience and Neural Engineering
2021 - Springer Nature | Basic Research in Cardiology
E Ionescu, Françoise Rohner‐Jeanrenaud, Hans‐Rudolf Berthoud, B. Jeanrenaud,
... the dorsal motor nucleus of the vagus nerve (DMX) is a source of efferent vagal fibers innervating ... 100 ml was performed in normal anesthetized rats. DMX stimulation resulted in rapid (within 1 min) rise ... the nucleus of tractus solitarius, anatomically connected to DMX, also produced a 50% increase in insulinemia. The effect of DMX stimulation was almost completely abolished by atropine pretreatment or acute bilateral subdiaphragmatic vagotomy. The effect of DMX stimulation was not potentiated by the alpha-adrenergic ...
Tópico(s): Heart Rate Variability and Autonomic Control
1983 - Oxford University Press | Endocrinology
Kiyofumi Yamamoto, Jun Noguchi, Chiaki Yamada, Ayako M. Watabe, Fusao Kato,
... the dorsal motor nucleus of the vagus nerve (DMX), via the vagus and glossopharyngeal nerves and then ... dependence and short-term plasticity at the TS-DMX synapses, which also transmit monosynaptic information from the ... 0.6, the distribution of the PPR of DMX neurons shows bimodal peaks that are composed of ... 6; 47%) neurons. Some of the type I DMX neurons showed paired-pulse potentiation. The distinction of ... EPSC amplitude in the NTS and type II DMX neurons, whereas type I DMX neurons displayed only slight decreases, which indicates that ...
Tópico(s): Neuroscience and Neuropharmacology Research
2010 - BioMed Central | BMC Neuroscience
David A. Ruggiero, Lee‐Young Chau, M. Anwar, Estomih P. Mtui, Eugene V. Golanov,
... in the dorsal motor nucleus of the vagus (DMX) were revealed by a clearcut depletion of intracellular ... segregated populations of catecholaminergic visceromotor neurons in the DMX. These cell bodies were morphologically identical to preganglionic ... biosynthesizing acetylcholine. Neurons in the central and medial DMX demonstrated fall-off of TH-like immunoreactivity (LI) ... relatively few neurons at this level of the DMX expressed DβH-LI and none were immunostained for ... concentrated in the rostral-lateral region of the DMX, was depleted of DβH-LI on the ipsilateral ...
Tópico(s): Nerve injury and regeneration
1993 - Elsevier BV | Brain Research
Franco Benazzi, Hagop S. Akiskal,
Background: Depressive mixed state (DMX), defined by hypomanic features during a major depressive episode (MDE) is under-researched. Accordingly, study aims were to find DMX prevalence in unipolar major depressive disorder (MDD) and ... the most common hypomanic signs and symptoms during DMX, and to assess their sensitivity and specificity for the diagnosis of DMX and bipolar II. Methods: 161 unipolar and bipolar ... with the Structured Clinical Interview for DSM-IV. DMX was defined at two threshold levels as an ...
Tópico(s): Stuttering Research and Treatment
2001 - Elsevier BV | Journal of Affective Disorders
Moo Ho Won, Koji Matsuo, Yang Seok Oh, Junjoh Kitoh,
... the dorsal motor nucleus of the vagus nerve (DMX) and ambiguous nucleus (AN). Labelled neurons in the DMX were observed from all regions except from the ... more labelled neurons were observed on the right DMX from subdiaphragmatic esophagus, cardia, lesser curvature and ventral corpus, while on the left DMX from the dorsal corpus labelled neurons in the longitudinal extent of the DMX were generally located at the dorsal and dorsomedial ... murinus the rostrocaudal site-specific localization within the DMX was not found, but it was prominent in ...
Tópico(s): Sleep and Wakefulness Research
1998 - Elsevier BV | Journal of the Autonomic Nervous System
Roberto Latini, Maurizio Bonati, Flavio Gaspari, Gian Luigi Traina, L Jiritano, Angela Bortolotti, Joseph F. Borzelleca, Stanley M. Tarka, Maurice J. Arnaud, Silvio Garattini,
The kinetics and metabolism of theobromine (3,7- DMX ) were investigated in male rabbits after a single ... found in the pharmacokinetic profile of 3,7- DMX due to either sex, pregnancy or after chronic ... days. Intravenous (i.v.) administration of 3,7- DMX at 1 and 5 mg/kg resulted in ... qualitative difference in the metabolism of 3,7- DMX in the rabbit was observed as linked to ... percent of the administered dose of 3,7- DMX was excreted unchanged, the major metabolite being 7- ... in the females with more unchanged 3,7- DMX excreted. Only at these highest doses (100 mg/ ...
Tópico(s): Pharmacology and Obesity Treatment
1984 - Elsevier BV | Toxicology
Seng Kee Leong, Sam Wah Tay, Wai Chow Wong,
... the dorsal motor nucleus of the vagus nerve (DMX), in the nucleus ambiguus (NA), in an area located ventral to the DMX, and less definitely in the nucleus of the spinal accessory nerve. The DMX and NA neurons are bilaterally distributed with a predominant ipsilateral component. Labeled DMX neurons appear to have a slightly more extensive ... to the HN. Some recurrent collaterals of the DMX neurons loop round the medial longitudinal fasciculus to end in a region immediately ventrolateral to the DMX. Transganglionic sensory fibers course with the tractus solitarius ...
Tópico(s): Comparative Animal Anatomy Studies
1984 - Elsevier BV | Journal of the Autonomic Nervous System
Patrik Schmuki, Lionel Santinacci, Thierry Djenizian, D. J. Lockwood,
... Institute of Technology, Department of Materials Science, LC-DMX, CH-1015 Lausanne, SwitzerlandSearch for more papers by ... Institute of Technology, Department of Materials Science, LC-DMX, CH-1015 Lausanne, SwitzerlandSearch for more papers by ... Institute of Technology, Department of Materials Science, LC-DMX, CH-1015 Lausanne, SwitzerlandSearch for more papers by ... Institute of Technology, Department of Materials Science, LC-DMX, CH-1015 Lausanne, SwitzerlandSearch for more papers by ... Institute of Technology, Department of Materials Science, LC-DMX, CH-1015 Lausanne, SwitzerlandSearch for more papers by ...
Tópico(s): Nanowire Synthesis and Applications
2000 - Wiley | physica status solidi (a)
Christiane Kraemer, Thorsten Enklaar, Bernhard Zabel, Erwin R. Schmidt,
The DmX gene was recently isolated from the X chromosome of Drosophila melanogaster. TBLASTN searches of the dbEST databases ... sequences with a high level of similarity to DmX in a variety of different species, including insects, nematodes, and mammals showing that DmX is an evolutionarily highly conserved gene. Here we ... localization of one of the human homologues of DmX, Dmx-like 1 (DMXL1). The human DMXL1 gene codes ...
Tópico(s): Genomics and Phylogenetic Studies
2000 - Elsevier BV | Genomics
Gianni L. Faedda, Ciro Marangoni,
... symptoms, mostly referred to as depressive mixed states (DMX), have been poorly characterized, and their treatment offers significant challenges. To understand the diagnostic context of DMX, we trace the nosological changes and collocation of ... so little is known about the treatment of DMX is that depressed patients with rapid cycling, substance ... from clinical trials of antidepressants. The exclusion of DMX patients from clinical trials has prevented an assessment ... shows that antidepressants alone have limited efficacy in DMX, but they have the potential to induce, maintain, ...
Tópico(s): Coordination Chemistry and Organometallics
2016 - Cambridge University Press | CNS Spectrums
Norihito Uemura, Hisashi Yagi, Maiko Uemura, Yusuke Hatanaka, Hodaka Yamakado, Ryōsuke Takahashi,
... the dorsal motor nucleus of the vagus nerve (dmX), proceeding from there in a caudo-rostral direction. ... demonstrating this transmission from the ENS to the dmX and then to the SNpc. We inoculated α- ... α-Syn)–positive LB-like aggregates in the dmX at 45 days postinoculation. This aggregate formation was ... Syn PFFs, suggesting that the aggregates in the dmX were retrogradely induced via the vagus nerve. Unexpectedly, ... containing p-α-Syn–positive aggregates in the dmX decreased over time, and no further caudo-rostral ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2018 - BioMed Central | Molecular Neurodegeneration
Arnold J. Smolen, Raymond C. Truex,
The dorsal motor nucleus of the vagus nerve (DMX) of adult cats and young kittens was studied ... quantitative light microscopic methods. In normal animals, the DMX was found to contain no distinct subgroupings of ... perikaryal responses to axotomy of neurons in the DMX were found to be of a more subtle ... most if not all neurons of the ipsilateral DMX contribute axons to the cervical vagus nerve. In ... axons with cell bodies located in the contralateral DMX.
Tópico(s): Vagus Nerve Stimulation Research
1977 - Wiley | The Anatomical Record
Annette L. Kirchgessner, Michael D. Gershon,
... from the dorsal motor nucleus of the vagus (DMX). The current experiments were undertaken as a partial ... vulgaris leucoagglutinin (PHA‐L) was injected into the DMX by iontophoresis, and 10–21 days later PHA‐ ... and a subset of the neurons of the DMX that were labeled by retrograde transport of Fluro‐ ... like peptide is present in neurons of the DMX that innervate gastric myenteric ganglia. Although TH‐immunoreactive ... nerves, therefore, are probably not derived from the DMX but are sympathetic postganglionic axons. These observations are ...
Tópico(s): Gastroesophageal reflux and treatments
1989 - Wiley | The Journal of Comparative Neurology
Ludovic Raynal, Pascal Alix, Pierre-Antoine Bouillon, Adrien Gomez, Marie le Febvre de Nailly, Marc Jacquin, Jean Kittel, Angella di Lella, Pascal Mougin, Jean Trapy,
... to operate. This paper aims at presenting the DMX™ process developed at IFP Energies nouvelles based on ... other processes and some further information about the DMX™ process are given. Operational issues are particularly discussed. In that sense, the performances of the DMX-1TM solvent in terms of degradation and corrosion ... separation which is a key aspect of the DMX™ process.
Tópico(s): Thermodynamic and Exergetic Analyses of Power and Cooling Systems
2011 - Elsevier BV | Energy Procedia
Karel Krofta, Josef Patzak, Vladimír Nesvadba, Alexandr Mikyška, Martin Slabý, Pavel ČEJKA,
... Nejvýznamnějším znakem odrůdy Vital je vysoký obsah desmethylxanthohumolu (DMX). DMX je znám jako prekurzor 8-prenylnaringeninu, vysoce účinného ... výrobu doplňků stravy. V zelených hlávkách činí obsah DMX až 0,50-0,70 % hm. Vzhledem k omezené stabilitě DMX dochází již při sušení k poměrně významným ztrátám, ... provozních teplotách sušení 55-60 °C činí ztráta DMX více než 30 % rel. Pro využití k nepivovarským ...
Tópico(s): Fermentation and Sensory Analysis
2013 - Research Institute of Brewing and Malting | Kvasny Prumysl