Miscellaneous Free eBooks
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... Room Classical choice Arthur Lee and Love Music Dpz Choice Essentials five recent albums you should own ...
2003 - Gale Group | TDA
Sun-Hye Choi, Na-Eun Lee, Hee‐Jung Cho, Ra Mi Lee, Hyewhon Rhim, Hyoung‐Chun Kim, Mun Han, Eun Hee Lee, Ju Young Park, Jeong Nam Kim, Byung Joo Kim, Seung-Yeol Nah,
... whether gintonin can enhance brain delivery of donepezil (DPZ) (Aricept), which is a representative cognition-improving drug ... administration of gintonin can stimulate brain delivery of DPZ.We administered gintonin and DPZ alone or coadministered gintonin with DPZ intravenously or orally to rats. Then we collected ... spinal fluid (CSF) and serum and determined the DPZ concentration through liquid chromatography-tandem mass spectrometry (LC- ... Intravenous, but not oral, coadministration of gintonin with DPZ increased the CSF concentration of DPZ in a ...
Tópico(s): Neuroscience and Neuropharmacology Research
2019 - Elsevier BV | Journal of Ginseng Research
Da In Jeong, Sungyun Kim, Min Hwan Kim, In‐Soo Yoon, Seung Hwan Lee, Dae‐Duk Kim, Hyun‐Jong Cho,
A donepezil hydrochloride (DPZ)-reinforced cellulose nanocrystal (CNC) hydrogel structure with pH control was developed for sustained drug delivery through subcutaneous injection. In ... the electrostatic repulsion between CNC particles by incorporating DPZ and adjusting the pH value to 7.7. The crosslinked CNC/DPZ (cCNC/DPZ) gel exhibited immediate gelation, injection capability through a ... shear-thinning properties. Interactions between the CNCs and DPZ and pH regulation were assessed using several solid- ...
Tópico(s): Hydrogels: synthesis, properties, applications
2022 - Elsevier BV | Carbohydrate Polymers
Mohd Yasir, Ameeduzzafar Zafar, K.M. Noorulla, Abdurazak J. Tura, Udai Vir Singh Sara, Dharamveer Panjwani, Mohammad Khalid, Misbahu J. Haji, Wondesen G. Gobena, Teshome Gebissa, Debesa D. Dalecha,
The research was aimed to formulate the Donepezil (DPZ)-loaded nanostructured lipid carriers (NLCs) and coated with ... levels Box-Behnken design (BBD). The composition of DPZ-loaded CH-NLCs was established by using a ... DTP), etc of the optimized formulation. Optimized formulation (DPZ-CH-NLCs-OPT2) exhibited an acceptable particle size ( ... within the NLCs matrix. Permeability coefficient (Papp) of DPZ-CH-NLCs-OPT2 formulation (10.14 ± 1.73 × ... 3 cm h−1) was two folds than DPZ-Sol (4.55 ± 1.18 × 10−3 cm h−1). The nasal absorption rate constant for DPZ-CH-NLCs-OPT2 (1.4 × 10−3 h− ...
Tópico(s): Advancements in Transdermal Drug Delivery
2022 - Elsevier BV | Journal of Drug Delivery Science and Technology
Produção Nacional
Revisado por pares
Thiago Caon, Yijun Pan, Cláudia Maria Oliveira Simões, Joseph A. Nicolazzo,
... alternative route for the systemic delivery of donepezil (DPZ) hydrochloride, and the impact of various skin penetration enhancers on DPZ buccal permeability, was assessed using an in vitro model. DPZ was applied to porcine buccal mucosa in modified ... PEG) 400, and oleic acid (OA)-PEG 400. DPZ permeated the buccal mucosa very rapidly with a ... 01% (w/w), reduced the buccal permeation of DPZ (3.5-fold), and PEG 400 reduced the absorption of DPZ in a concentration-dependent manner (1.6- and ... and PEG 400 5% (w/w) further reduced DPZ permeability (5.5-fold), which was demonstrated to ...
Tópico(s): Alzheimer's disease research and treatments
2014 - Elsevier BV | Journal of Pharmaceutical Sciences
Chong‐Qing Wan, Ya Zhang, Xin-Zhan Sun, Hao-Jie Yan,
... based on a new multidentate di-2-pyrazinylsulfide (DpzS) ligand and various anions, namely {[Ag3(DpzS)2(ClO4)2](ClO4)}∞ (1), [Ag3(DpzS)2(CF3SO3)3]∞ (2), {[Ag3(DpzS)2(CF3SO3)(H2O)2](CF3SO3)2·H2O}∞ (3), [Ag2(DpzS)(NO3)2(H2O)]∞ (4), [Ag(DpzS)(NO2)]∞ (5), [Ag2(DpzS)(NO2)2]∞ (6) and [Ag2(DpzS)(C2F5CO2)2]∞ (7), have been synthesized and fully ... powder X-ray diffraction. In 1–7, the DpzS ligand exhibits diverse coordination modes with various silver( ...
Tópico(s): Organometallic Compounds Synthesis and Characterization
2014 - Royal Society of Chemistry | CrystEngComm
Sayaka Nagasawa, N. KATAGIRI, Akina Nara, Fumiko Chiba, Yuko Kubo, Suguru Torimitsu, Daisuke Yajima, Mamoru Akutsu, Hirotaro Iwase,
... disease (AD) is rising. The safety of donepezil (DPZ), which is used for AD treatment, has been ... clinical trials. However, some studies have indicated that DPZ may be associated with severe cardiac side effects, ... symptoms or death. Therefore, the measurement of blood DPZ levels is important for the postmortem investigation of ... study was to investigate the potential PMR of DPZ using a rat model. The DPZ concentration was measured using a validated HPLC/Q- ... 1, 3, 6, 12, and 24h). Overall, the DPZ tissue to peripheral blood ratio decreased throughout the ...
Tópico(s): Schizophrenia research and treatment
2016 - Elsevier BV | Forensic Science International
Gilbert Audira, Nguyễn Thị Ngọc Ánh, Bui Thi Ngoc Hieu, Nemi Malhotra, Petrus Siregar, Omar Villalobos, Oliver B. Villaflores, Tzong-Rong Ger, Jong‐Chin Huang, Kelvin H.‐C. Chen, Chung‐Der Hsiao,
Donepezil (DPZ) is an acetylcholinesterase inhibitor used for the clinical treatment of mild cognitive impairment. However, DPZ has been reported to have adverse effects, including ... deeper analysis of the potential adverse effects of DPZ on the short-term memory and behaviors of ... to 1 ppm and 2.5 ppm of DPZ. From the results, DPZ caused a slight improvement in the short-term ... revealed anxiolytic-like behavior to be caused by DPZ. Furthermore, zebrafish circadian locomotor activity displayed a higher ...
Tópico(s): Memory and Neural Mechanisms
2020 - Multidisciplinary Digital Publishing Institute | Biomolecules
Linh Đinh, Soohun Lee, S. ABUZAR, Heejun Park, Sung‐Joo Hwang,
Donepezil (DPZ) is generally administered orally to treat Alzheimer's disease (AD). However, oral administration can cause gastrointestinal side ... to enhance compliance, a new way to deliver DPZ from transdermal patch was developed. Ionic bonds were created by dissolving dicarboxylic acid and DPZ in ethanol, resulting in a stable ionic liquid ( ... infrared spectroscopy and nuclear magnetic resonance spectroscopy. The DPZ ILs were then transformed to a suitable drug-in-adhesive patch for transdermal delivery of DPZ. The novel DPZ ILs patch inhibits crystallization of ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2022 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Tatsuya Noguchi, Yoshihiko Kakinuma, Mikihiko Arikawa, Kayo Okazaki, Eri Hoshino, Tatsuo Iiyama, Toru Kubo, Hiroaki Kitaoka, Yoshinori Doi, Takayuki Sato,
... We hypothesized that an anti-Alzheimer drug, donepezil (DPZ), can activate angiomyogenic properties of satellite cells, myogenic ... the angiogenic effects of a clinical dose of DPZ (0.2 mg·kg–1·day–1) and ... cells in ischemic hindlimbs. Computed tomography revealed that DPZ remarkably attenuated ischemic muscle atrophy and induced super- ... study with human aortic endothelial cells showed that DPZ or its combination with cilostazol effectively upregulated the ... VEGF protein. Likewise, in primary cultured satellite cells, DPZ, alone or in combination, upregulated the expression of ...
Tópico(s): Stroke Rehabilitation and Recovery
2014 - Japanese Circulation Society | Circulation Journal
S. Delimitreva, Edris Wedi, Jaco Bakker, Olena Tkachenko, V. Nikolova, P. L. Nayudu,
... marmosets from two colonies – D eutsches P rimatenzentrum ( DPZ ) and Biomedical Primate Research Centre ( BPRC ). Chlorine‐based disinfectants are used in DPZ ; no chemical disinfection is applied in BPRC . Methods ... endoreduplication were investigated after G‐banding. Results For DPZ monkeys, the mean rates of non‐disjunction were ... 1.3%) was significantly lower than that for DPZ ; the polyploidy rate (0.2%) in blood was lower than that in DPZ ; endoreduplication was not observed. Conclusion The levels of chromosomal disorders are elevated for DPZ colony. We suggest that the increased rate of ...
Tópico(s): DNA and Nucleic Acid Chemistry
2013 - Wiley | Journal of Medical Primatology
... of the combination of KKT extract and donepezil ( DPZ ) on the cognitive function of patients diagnosed with ... E xamination ( MMSE ). AD patients were treated with DPZ (5 mg/day). Those with psychological symptoms, such ... day), beginning 3 months after the initiation of DPZ . Results Medical records of patients who visited the ... study. Changes in total MMSE score for the DPZ and CBT groups were unremarkable until 6 months; ... the CBT group while it deteriorated in the DPZ group. On MMSE subscale analysis, delayed memory recall ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2016 - Wiley | Traditional & Kampo Medicine
Lupe Carolina Espinoza, Marcelle Silva-Abreu, Beatriz Clares, María J. Rodríguez-Lagunas, Lyda Halbaut, María-Alexandra Cañas, Ana C. Calpena,
Donepezil (DPZ) is widely used in the treatment of Alzheimer's disease in tablet form for oral administration. The ... PNE) in order to facilitate the transport of DPZ from nose-to-brain. Composition of NE was ... evaluated by in vitro and in vivo models. DPZ-NE and DPZ-PNE were transparent, monophasic, homogeneous, and physically stable with droplets of nanometric size and spherical shape. DPZ-NE showed Newtonian behavior whereas a shear thinning (pseudoplastic) behavior was observed for DPZ-PNE. The release profile of both formulations followed ...
Tópico(s): Drug Solubulity and Delivery Systems
2019 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Marco Onofrj, Astrid Thomas, Anna Lisa Luciano, Diego Iacono, A. Di Rollo, Giordano D’Andreamatteo, Angelo Di Iorio,
... the hypothesis that new cholinesterase inhibitors like Donepezil (DPZ) may have an effect on the often abnormal ... four groups of 15 patients each: Group I DPZ (10 mg/day) and Group I Vitamin E (2000 IU/day) with "mild" AD; Group II DPZ and Group II Vitamin E with "moderate–severe" ... period, and the difference between Vitamin E and DPZ treated patients was highly significant for P3 (analysis ... groups of patients with AD and Group II (DPZ) versus Group II (Vitamin E). Combined P3 event ... measurements, neuropsychologic test comparison evidences significant effects of DPZ in mild and in moderate–severe AD.
Tópico(s): Alzheimer's disease research and treatments
2002 - Lippincott Williams & Wilkins | Clinical Neuropharmacology
Yuzhe Wu, Yi Peng, Xiaoling Zhang, Martin Skitmore, Yan Song,
... many regions. The strategy of development priority zoning (DPZ), proposed by the Chinese National 11th Five-Year ... utilization of land, it is proposed that the DPZ strategy should be integrated with regional land use ... land use change in China led by the DPZ strategy. Land use is characterized by the prioritisation ... RDZ strategy. The findings enable a conceptualization of DPZ-led land use change and the identification of ... a potential tool for local government to combine DPZ strategy at the national level with land use ...
Tópico(s): Coastal and Marine Management
2011 - Elsevier BV | Habitat International
Yunhui Li, Chunyan Wang, Jinying Sun, Yongchang Zhou, Tianyan You, Erkang Wang, Yingsing Fung,
... rapid method for the determination of dioxopromethazine hydrochloride (DPZ), an antihistamine drug, by the capillary electrophoresis with ... has high sensitivity, good selectivity and reproducibility for DPZ analysis. Under the optimized conditions: separation capillary, 38 ... in ECL detection cell, the detection limit of DPZ was 0.05 μmol L−1 (S/N = ... six continuous injections of 5 μmol L−1 DPZ were 3.7% and 0.92%, respectively. The CE–ECL method was applied to analyze DPZ in real samples including tablets, rat serum and ...
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2005 - Elsevier BV | Analytica Chimica Acta
Astrid Thomas, Diego Iacono, Laura Bonanni, Giordano D’Andreamatteo, Marco Onofrj,
... the hypothesis that the new cholinesterase inhibitors donepezil (DPZ) and rivastigmine (Riv) may have an effect on ... double-blinded trial to 5–10 mg/d DPZ versus 2,000 IU/d vitamin E, and ... worsening neuropsychologic test scores. In patients treated with DPZ and Riv, we found significant P300 latency reductions ( ... and P300 changes significantly separated patients treated with DPZ and Riv from those treated with vitamin E. Administration of DPZ and Riv reduced the latencies of P300 components ... Combined P300 and neuropsychologic test evaluation significantly separated DPZ-treated patients and Riv-treated patients from vitamin ...
Tópico(s): Alzheimer's disease research and treatments
2001 - Lippincott Williams & Wilkins | Clinical Neuropharmacology
Steph Bennington, Will Rayment, Rohan J. C. Currey, Lucy Oldridge, S Henderson, Marta Guerra, Tom Brough, David Johnston, Chloe Corne, David Samuel Johnson, Elisabeth Slooten, Steve Dawson,
... voluntary Code of Management incorporating dolphin protection zones (DPZs), in which tour boat access is limited, was ... quantitative estimates of the extent of overlap between DPZs and core areas (50% volume contour) of habitat ... between the area of core dolphin habitat and DPZs was low (<18%) overall, and some DPZs were rarely used during colder periods. Consistency in ... but low overlap between core habitat and current DPZs suggests that an expansion of the DPZ areas would confer greater protection.
Tópico(s): Wildlife Ecology and Conservation
2020 - Wiley | Aquatic Conservation Marine and Freshwater Ecosystems
Song Yi Lee, Ju-Hwan Park, Ming‐Yu Yang, Min‐Jun Baek, Min Hwan Kim, Junmin Lee, Ali Khademhosseini, Dae‐Duk Kim, Hyun‐Jong Cho,
... hyaluronic acid-dopamine (HA-dp) that contain donepezil (DPZ)-entrapping poly(lactic-co-glycolic acid) (PLGA) microsphere (MS). Although DPZ has been administered orally, its sustained release formulation ... and self-polymerization of dp. The HA-dp/DPZ-loaded PLGA MS (PD MS)/FeSO4 gel system ... restoration of the collapsed gel structure and sustained DPZ release from the HA-dp/PD MS/FeSO4 ... rat indicate the sustained release and absorption of DPZ from the HA-dp/PD MS/FeSO4 system. ... safely used for the long-term delivery of DPZ after the subcutaneous injection.
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2020 - Elsevier BV | International Journal of Pharmaceutics
Marco Onofrj, Astrid Thomas, Diego Iacono, Anna Lisa Luciano, Angelo Di Iorio,
... of a double-blind crossover study of donepezil (DPZ), a 5 to 10-mg dose, versus vitamin ... end of the crossover study all patients received DPZ for 6 months. The dominant EEG frequency variability, ... group at baseline (P < 0.001). Short-term DPZ administration induced a significant increase in MMSE scores, ... 0.041) in the nonfluctuating group. Short-term DPZ effects differed significantly between fluctuating cognition and nonfluctuating ... showed that P3 latency predicts the effect of DPZ (P = 0.04, P < 0.01) in the ...
Tópico(s): Neural and Behavioral Psychology Studies
2003 - Lippincott Williams & Wilkins | Clinical Neuropharmacology
Sander Deridder, Alison Vanmessen, Kazuki Nakanishi, Gert Desmet, Deirdre Cabooter,
... core–shell particles. The intra-skeleton diffusion coefficient (Dpz) was typically found to be of the order of Dpz/Dmol = 0.4, compared to Dpz/Dmol = 0.2–0.35 observed in most particle-based columns. These higher Dpz/Dmol values are the cause of the higher ... relatively wide pores. The observed (weak) relation between Dpz/Dmol and the zone retention factor appears to ...
Tópico(s): NMR spectroscopy and applications
2014 - Elsevier BV | Journal of Chromatography A
Lupe Carolina Espinoza, Marisol Vacacela, Beatriz Clares, María L. García, María-José Fábrega, Ana C. Calpena,
Donepezil (DPZ) is widely prescribed as a specific and reversible acetylcholinesterase inhibitor for the symptomatic treatment of mild to ... s disease (AD).Considering the therapeutic potential of DPZ and the advantages offered by the intranasal route ... study was the development and characterization of a DPZ microemulsion (ME) for nose-to-brain delivery.The ... nasal mucosa were accomplished.A transparent and homogeneous DPZ-ME (12.5 mg/ml) was obtained. The ... regular surface. Optical stability evidenced no destabilization processes. DPZ release profile indicated that the ME followed a ...
Tópico(s): Drug Solubulity and Delivery Systems
2018 - Bentham Science Publishers | CNS & Neurological Disorders - Drug Targets
Ji‐Hye Seo, Song Yi Lee, Sungyun Kim, Ming‐Yu Yang, Da In Jeong, ChaeRim Hwang, Min Hwan Kim, Han‐Jun Kim, Junmin Lee, KangJu Lee, Dae‐Duk Kim, Hyun‐Jong Cho,
... as one of subcutaneous injection formulations of donepezil (DPZ). Both incorporation of KH2PO4 and pH adjustment finally ... the optimization of KH2PO4 concentration in hydrogel systems. DPZ base (as a poorly water soluble drug) was ... release. Biodegradability of designed KH2PO4-incorporated HA-dopa/DPZ MS hydrogel system was assessed by optical imaging ... 05). Subcutaneous injection of KH2PO4-incorporated HA-dopa/DPZ MS hydrogel did not induce any severe systemic ... All these data suggest that designed HA-dopa/DPZ MS hydrogel structure crosslinked by KH2PO4 incorporation and ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2020 - Elsevier BV | International Journal of Biological Macromolecules
Marine Droguerre, Adeline Duchêne, Christèle Picoli, Benjamin Portal, Camille Lejards, Bruno P. Guiard, Johann Meunier, Vanessa Villard, Nicole Déglon, M. Hamon, Franck Mouthon, Mathieu Charvériat,
Donepezil (DPZ) is an acetylcholinesterase inhibitor used in Alzheimer's disease to restore cognitive functions but is endowed with ... or genetic modulations of those astrocyte Cxs during DPZ challenge in two rodent models of Alzheimer's ... mefloquine (MEF) significantly enhanced the procognitive effect of DPZ in both models. In parallel, we determined that MEF potentiated DPZ-induced release of acetylcholine in hippocampus. Finally, local ... also found to enhance the procognitive effect of DPZ, pointing out the importance of Cx-dependent astrocyte ...
Tópico(s): Neuroscience and Neuropharmacology Research
2020 - Frontiers Media | Frontiers in Neuroscience
Chenbin Tang, Bangshuai Wei, Wu Tang, Yan Hong, Meichen Guo, Xuesong He, Jiahui Hu, Shan Jia, Cong Fan,
... namely N,N'-bis(2-anthraquinone)-dihydrophenazine (DAQ-DPZ, 270 mAh/g) with n-p-n molecular ... the dissolution for small-molecule organic electrodes, DAQ-DPZ is further coated by a protective carbon layer (DAQ-DPZ@C) through the process called surface self-carbonization. As expected, the resulting DAQ-DPZ@C can show the peak discharge capacity of ... in Li-dual-ion half cells. Furthermore, DAQ-DPZ@C in the symmetric Li-dual-ion batteries ...
Tópico(s): Advanced Battery Technologies Research
2023 - Elsevier BV | Chemical Engineering Journal
Benjamin Ongnok, Thawatchai Khuanjing, Titikorn Chunchai, Patcharapong Pantiya, Sasiwan Kerdphoo, Busarin Arunsak, Wichwara Nawara, Thidarat Jaiwongkam, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn C. Chattipakorn,
... causes debilitating neurological deficits known as chemobrain. Donepezil (DPZ), an acetylcholinesterase inhibitor, provides therapeutic benefits in various ... However, comprehensive mechanistic insights regarding the neuroprotection of DPZ on cognition and brain pathologies in a Dox- ... death through both apoptosis and necroptosis. Intervention with DPZ co-treatment completely restored cognitive function by attenuating ... conditions induced by DOX. We also confirmed that DPZ treatment does not affect the anti-cancer efficacy ...
Tópico(s): Chemotherapy-induced cardiotoxicity and mitigation
2021 - Springer Science+Business Media | Neurotherapeutics
Y. Lakshmisha Rao, B Ganaraja, Aradhana Marathe, Poornima Manjrekar, Teresa Joy, Sheetal D Ullal, Mangala M. Pai, B.V. Murlimanju,
... disease ( AD), resveratrol ( RS) treated and RS + donepezil (DPZ) treated rat models. The objective was to compare ... included control, sham, AD induced, RS treated and DPZ treated groups in different doses and combinations. The ... to the AD group ( p < 0.05). In DPZ + RS group, there was a substantial increase in ... the improved oxidative stress–defence mechanism. The RS + DPZ group showed higher SOD activity, indicating a synergistic effect of DPZ and RS.
Tópico(s): Medicinal Plants and Neuroprotection
2021 - Springer Science+Business Media | 3 Biotech
Minjie Shi, Jing He, Yüe Zhao, Liping Zhao, Kun Dai, Chao Yan,
... so far. Herein, a rod-like diquinoxalino-phenazine (DPZ) organic compound is designed and synthetized via a ... to probe into the proton redox process of DPZ organic electrode for the first time. It is demonstrated that three CN electroactive regions in each DPZ molecular unit could be simultaneously coordinated with two ... reversible upon proton insertion/extraction. As expected, the DPZ organic electrode delivers a large proton-storage capacity ... package and wire-shaped APBs based on such DPZ organic electrode are constructed, and they both achieve ...
Tópico(s): Conducting polymers and applications
2022 - Elsevier BV | Materials & Design
... rats were assigned to untreated and donepezil-treated (DPZ) groups.At the chronic phase of MI, resting heart rate was comparable between the untreated and DPZ groups.Nevertheless, left ventricular contractility evaluated in Langendorff- ... glucose transporter (GLUT) was significantly higher in the DPZ group than in the untreated group.In vitro ... cellular glucose uptake.Moreover, the beating rate of DPZ cardiomyocytes was approximately 2-fold higher than that ...
Tópico(s): Neuroscience and Neuropharmacology Research
2014 - OMICS Publishing Group | Cardiovascular Pharmacology Open Access