Abstract. QT interval prolongation is incontrovertibly linked to increased risk of arrhythmias but, paradoxically, QT interval prolongation can also be an effective antiarrhythmic strategy and is in fact the goal of class III antiarrhythmic drugs. This discussion examines the cellular effects of QT interval prolongation and proposes that calmodulin kinase II (CaMKII) is a specific cellular proarrhythmic signal that is activated downstream to QT interval prolongation. Inhibition of CaMKII can prevent ...
Tópico(s): Receptor Mechanisms and Signaling
2005 - Wiley | Journal of Internal Medicine
Tópico(s): Advanced Graph Theory Research
1995 - Springer Science+Business Media | Graphs and Combinatorics
Sometimes it seems as if everyone has bought into the hype: Industries as far-flung as real estate and diamond sales have embraced block-chain without entirely knowing what it is or how its most vaunted features might fail or have unintended consequences. Block-chain assures users that once information has been stored, it can never be deleted or falsified. This means that when people in finance, say, pore over the history of a transaction, they feel content in the knowledge that illegalities have ...
Tópico(s): Blockchain Technology Applications and Security
2019 - RELX Group (Netherlands) | SSRN Electronic Journal
A product is on the way that relies on the quantum properties of photons to keep out eavesdroppers. All of them. The battle between codemakers and codebreakers is centuries old, but at the start of the 21st century, could it finally be drawing to a close? Physicists are putting the finishing touches to a method of encrypting messages that is more secure than anything that has gone before. Unlike the ciphers of the past, this new method has the potential to be absolutely unbreakable, not just practically ...
Tópico(s): Quantum Information and Cryptography
2002 - Institute of Electrical and Electronics Engineers | IEEE Spectrum
Gianluca Veggiani, Bijan Zakeri, Mark Howarth,
Biotechnology is often limited by weak interactions. We suggest that an ideal interaction between proteins would be covalent, specific, require addition of only a peptide tag to the protein of interest, and form under a wide range of conditions. Here we summarize peptide tags that are able to form spontaneous amide bonds, based on harnessing reactions of adhesion proteins from the bacterium Streptococcus pyogenes . These include the irreversible peptide–protein interaction of SpyTag with SpyCatcher, ...
Tópico(s): Peptidase Inhibition and Analysis
2014 - Elsevier BV | Trends in biotechnology
Abstract A nonempty set C of vertices is a star‐cutset in a graph G if G – C is disconnected and some vertex in C is adjacent to all the remaining vertices in C. Vašek Chvátal proposed to call a graph G unbreakable if neither G nor its complement G has a star‐cutset. A path with four vertices and three edges will be termed a P 4 . An edge uv of a graph G is called a wing, if for some vertices x, y , { u,v,x,y } induces a P 4 in G . We define recursively the coercion class C uv of a wing uv as follows: uv ∈ C ...
Tópico(s): Limits and Structures in Graph Theory
1991 - Wiley | Journal of Graph Theory
Some NFL football teams see physiological profiling as a means to protect and enhance their competitive and business success. Whether football players will benefit by increased performance and fewer injuries remains to be seen.
Tópico(s): Sports injuries and prevention
1981 - Taylor & Francis | The Physician and Sportsmedicine
Kaoru Shimizu, Nobuyuki Imoto,
This paper proposes a simple scheme for quantum-bit commitment that is secure against individual particle attacks, where a sender is unable to use quantum logical operations to manipulate multiparticle entanglement for performing quantum collective and coherent attacks. Our scheme employs a cryptographic quantum communication channel defined in a four-dimensional Hilbert space and can be implemented by using single-photon interference. For an ideal case of zero-loss and noiseless quantum channels, ...
Tópico(s): Quantum Mechanics and Applications
2002 - American Physical Society | Physical Review A
Antonio Macciò, Clelia Madeddu, Eleonora Lai, Mario Scartozzi,
Tópico(s): Long-Term Effects of COVID-19
2023 - Springer Nature | British Journal of Cancer
In the present work, the roles of inorganic oxide nanoparticles on the extraction efficiency of polyethylene terephthalate-based nanocomposites were extensively studied. Four fiber coatings based on polyethylene terephthalate nanocomposites containing different types of nanoparticles along with a pristine polyethylene terephthalate polymer were conveniently electrospun on stainless steel wires. The applicability of new fiber coatings were examined by headspace-solid phase microextraction of some ...
Tópico(s): Extraction and Separation Processes
2014 - Elsevier BV | Journal of Chromatography A
Everyday life information seeking (ELIS) is a relatively new branch of user studies that examines information behavior in daily life activities. In this study, as an example of ELIS, Korean graduate students' everyday lives in the United States are explored, focusing on their perspectives with respect to main stream society and the role of their ethnic church in their everyday lives. This study combines the grounded theory method with in-depth interviews of eight students and their spouses, as well ...
Tópico(s): Social Media and Politics
2004 - Elsevier BV | Library & Information Science Research
To analyze the robustness of randomized controlled trials (RCTs) referenced in the American Diabetes Association's Standards of Medical Care in Diabetes-2017 using the Fragility Index (FI) and Fragility Quotient (FQ).We performed a systematic survey of all RCTs referenced in the Standards of Medical Care in Diabetes-2017. One investigator screened for trials and then recorded data from them, including sample size per group, event rate per group, and the dichotomous outcome analyzed by trialists. The ...
Tópico(s): Diabetes Management and Research
2017 - Elsevier BV | Diabetes Research and Clinical Practice
Sibongiseni Malinga, Aabida Khan, Moherndran Archary,
We report a case of dolutegravir resistance in KwaZulu-Natal in a 13-year-old male two years after starting dolutegravir. Resistance most likely developed due to poor adherence as a result of psychosocial issues. This case highlights the importance of the role of the family unit in impacting adherence and close monitoring of treatment-experienced patients with virologic failure following switching to dolutegravir-based regimens.
Tópico(s): Acute Lymphoblastic Leukemia research
2023 - AOSIS | Southern African Journal of HIV Medicine
Habib Bagheri, Parisa Bayat, Hamed Piri‐Moghadam,
The present work deals with a novel approach for grafting a sol-gel based sorbent, using diazonium salts for preparation of an unbreakable capillary microextraction (CME) device in on-line combination with high performance liquid chromatography (HPLC). The use of diazonium salts modifier allowed all types of metallic and non-metallic substrates to be used without any limitation. Substrates including copper, brass, stainless steel and polytetrafluoroethylene (PTFE) were chosen to be functionalized by ...
Tópico(s): Electrochemical sensors and biosensors
2013 - Elsevier BV | Journal of Chromatography A
Abstract In this essay, we look at Titus Andromedon from the Netflix-sitcom Unbreakable Kimmy Schmidt (2014-) as a singular phenomenon in contemporary TV: a black queen whose use of camp distances him from stereotypes, but connects him with audiences. Titus thus not only adds to a more diverse representation of black experience on TV but also interrogates prevailing TV tropes. Titus thus presents a crucial (and critical) addition to the contemporary TV landscape, to which several TV critics in leading ...
Tópico(s): Sexuality, Behavior, and Technology
2017 - De Gruyter Open | Open Cultural Studies
In the years before World War II, German Intelligence Could Decode Band-Scrambled U.S. radiotelephone conferences. After Pearl Harbor, an unbreakable speech scrambler was developed with top priority, and by 1943, it was deployed. Known as SIGSALY, the device pioneered many advances critical to modern digital media technologies, including spread-spectrum communications and the first use of pulse-code modulation (PCM) to transmit speech. SIGSALY was top secret, so even today information about the details ...
Tópico(s): History of Computing Technologies
2019 - Institute of Electrical and Electronics Engineers | IEEE Spectrum
Habib Bagheri, Zahra Ayazi, Habiballah Sistani,
Tópico(s): Electrochemical Analysis and Applications
2011 - Springer Science+Business Media | Microchimica Acta
Yaroslav V. Kartashov, Boris A. Malomed, Lluís Torner,
We consider bright solitons supported by a symmetric inhomogeneous defocusing nonlinearity growing rapidly enough toward the periphery of the medium, combined with an antisymmetric gain-loss profile. Despite the absence of any symmetric modulation of the linear refractive index, which is usually required to establish a PT-symmetry in the form of a purely real spectrum of modes, we show that the PT-symmetry is never broken in the present system, and that the system always supports stable bright solitons, ...
Tópico(s): Nonlinear Waves and Solitons
2014 - Optica Publishing Group | Optics Letters
Konstantinos Κarampidis, Euangelos Linardos, Ergina Kavallieratou,
In the digital era we live, trustworthy verification schemes are required to ensure security and to authenticate the identity of an individual. Traditional passwords were proved to be highly vulnerable to attacks and the need of adopting new verification schemes is compulsory. Biometric factors have gained a lot of interest during the last years due to their uniqueness, ease of use, user convenience, and ease of deployment. However, recent research showed that even this unique authentication factors ...
Tópico(s): Generative Adversarial Networks and Image Synthesis
2021 - Springer Nature | Advances in intelligent systems and computing
Rachel Avshalomov, Natanel Jarach, Hanna Dodiuk,
Adhesives with polymeric bases are indispensable in joining various surfaces across numerous industries and applications. The recognition of environmental concerns and the demand for sustainable materials has spurred researchers to explore innovative strategies for improving the recyclability of polymeric adhesives. These adhesives are mostly thermosets-based, thus, infusible and insoluble in nature. This review discusses potential solutions for implementing covalent adaptable networks (CANs) in ...
Tópico(s): Advanced Polymer Synthesis and Characterization
2024 - Elsevier BV | European Polymer Journal
Ioannis Vrettos, Panagiota Voukelatou, Evelina Pappa, Chrysoula Beletsioti, Angelos Papadopoulos, Dimitris Niakas,
Adherence with lifestyle recommendations is low among hypertensive patients. The main objective of this study was to assess the prevalence of diagnosed hypertension among the Greek urban population and to examine how lifestyle and sociodemographic characteristics differ between already known hypertensive and the rest of the population.In this cross-sectional survey, data were collected from 1,060 participants (mean age 47.1 ± 16.9 (mean ± 1standard deviation), 52.7% females). Sociodemographic characteristics, ...
Tópico(s): Obesity, Physical Activity, Diet
2020 - Medknow | International Journal of Preventive Medicine
Habib Bagheri, Hamed Piri‐Moghadam, Ali Es‐haghi,
In this work a novel unbreakable sol–gel-based in-tube device for on-line solid phase microextraction (SPME) was developed. The inner surface of a copper tube, intended to be used as a high performance liquid chromatography (HPLC) loop, was electrodeposited by metallic Cu followed by the self assembled monolayers (SAM) of 3-(mercaptopropyl) trimethoxysilane (3MPTMOS). Then, poly (ethyleneglycol) (PEG) was chemically bonded to the –OH sites of the SAM already covering the inner surface of the copper loop ...
Tópico(s): Analytical Chemistry and Sensors
2011 - Elsevier BV | Journal of Chromatography A
Sara Cimino, Fabio Guarracino, Valentina Valenti, Giacomo Frati, Sebastiano Sciarretta, Fabio Miraldi, Luciano Agati, Ernesto Greco,
<b><i>Background:</i></b> Degenerative mitral valve (MV) disease causing mitral regurgitation (MR) is the most common organic valve pathology and is classified based on leaflet motion. MV repair is indicated as the preferred technique (Class I indication) when the results are expected to be durable. Therefore, a detailed and systematic evaluation of MV apparatus is pivotal in allowing the proper surgical planning, as well as the screening for trans catheter-based treatment when ...
Tópico(s): Cardiac Arrhythmias and Treatments
2019 - Karger Publishers | Cardiology
Inspired by the 2016 case of the encrypted Apple iPhone used by alleged terrorists in the San Bernardino, Calif. attack, this paper explores the question of whether the use of completely unbreakable encryption online or off-line would be considered ethical by the political philosopher John Rawls. Rawls is widely acknowledged as having played an important role in how we perceive freedom and liberty in Western democracies today, and his work on justice, fairness and liberty appears to be a great source ...
Tópico(s): Internet Traffic Analysis and Secure E-voting
2017 - University of Illinois at Chicago | First Monday
Vitaly Lutsky, Eitam Luz, Er’el Granot, Boris A. Malomed,
It is well known that typical $$\mathbb {PT}$$ -symmetric systems suffer symmetry breaking when the strength of the gain-loss terms, i.e., the coefficient in front of the non-Hermitian part of the underlying Hamiltonian, exceeds a certain critical value. In this article, we present a summary of recently published and newly produced results which demonstrate various possibilities of extending the $$\mathbb {PT}$$ symmetry to arbitrarily large values of the gain-loss coefficient. First, we recapitulate the ...
Tópico(s): Nonlinear Waves and Solitons
2018 - Springer Science+Business Media | Springer tracts in modern physics
Habib Bagheri, Habiballah Sistani, Zahra Ayazi,
Abstract A new technique for preparation of an unbreakable solid‐phase microextraction (SPME) fiber, using sol–gel technology is developed. Primarily, an ultrathin two‐dimensional intermediate film was prepared by hydrolysis of 3‐(trimethoxysilyl)‐1‐propanthiol self‐assembled monolayer grafted onto gold, then a stationary phase by electrodeposition of 3‐(trimethoxysilyl)propylmethacrylate as a precursor, tetramethyl orthosilicate and polyethylene glycol as a coating polymer was produced. The scanning ...
Tópico(s): Advanced Chemical Sensor Technologies
2011 - Wiley | Journal of Separation Science
Manuel Azenha, Pedro Nogueira, Fernando Silva,
Solid-phase microextraction commercial fibers present a few drawbacks such as relatively low recommended operating temperature, instability and swelling in organic solvents, breakage of the fiber, stripping of coatings, and bending of the needle. Some of these problems have been obviated by covalent bonding of the polymer phase to the fused-silica substrate by sol−gel, but the easy breakage of the fiber remains a problem. In the present work, the known occurrence of titanol groups at the surface ...
Tópico(s): Microfluidic and Capillary Electrophoresis Applications
2006 - American Chemical Society | Analytical Chemistry
Thokala Soloman Raju, Tejaswi Ashok Hegde, C.N. Kumar,
We demonstrate analytically and numerically the existence of exact solitons in the form of double kink and fractional transform, supported by a symmetric transversally modulated defocusing nonlinearity acting as a pseudopotential combined with an antisymmetric gain–loss profile. We explain here that the PT symmetry is never broken in the dynamical system under study, even in the absence of any symmetric modulation of linear refractive index, and the transversally modulated defocusing nonlinearity ...
Tópico(s): Nonlinear Photonic Systems
2015 - Optica Publishing Group | Journal of the Optical Society of America B
Sirwan Mohammadiazar, Ali Roostaie, Maryam Maghsoodi, Mehdi Maham,
Tópico(s): Analytical Chemistry and Sensors
2018 - Springer Science+Business Media | Chromatographia
The author describes the development of the scrambler called SIGSALY during World War II that was used for conversations between Churchill and Roosevelt and provides an early example of spread-spectrum communication.
Tópico(s): History of Computing Technologies
1984 - Institute of Electrical and Electronics Engineers | IEEE Spectrum