... tres elementos estructurales y litogenéticos: los arcos de Dabeiba y Baudó, las cuencas de Atrato-Chucunaque y la Zona Deformada de lstmina. Los arcos de Dabeiba y Baudó, con características similares, delimitan los márgenes ... ambientes, e intercalaciones volcánicas máficas. El Arco de Dabeiba presenta fábrica de tipo "melange", particularmente en sumargen ... microfauna planctónica del Paleoceno en el Arco de Dabeiba, plantea una proveniencia para el Bloque del Chocó ...
Tópico(s): Geological and Geophysical Studies Worldwide
1990 - | Boletín Geológico
Gabriel Rodríguez, María Isabel Arango, Gilberto Zapata, José Gilberto Bermúdez,
... Occidental, to the West of the town of Dabeiba (Antioquia).It crops out as a N-S ... total thickness of 2199.26 m in the Dabeiba -Mutata road between the Choromandó and Guineales creeks. ...
Tópico(s): Geological and Tectonic Studies in Latin America
2015 - Industrial University of Santander | Boletín de Geología
Astrid Carolina Flórez, Dabeiba Adriana García Robayo, Ligia Inés Moncada, Mauricio Beltrán,
Opportunistic intestinal parasites are a common cause of diarrhea in HIV-infected patients. To determine the prevalence of microsporidia and other opportunistic parasites infecting HIV patients in Bogotá, Colombia, 115 patients were examined for these infections during the year 2001. The institution and the sample percent from each are as follows: Santa Clara Hospital, 33.0%; San Pedro Claver, 20.0%; Simón Bolívar Hospital, 14.8%; San José Hospital, 13.9%; Central de la Policía Hospital, 6.1%; Compensar, ...
Tópico(s): Parasitic Infections and Diagnostics
2003 - National Institute of Health | Biomédica
Juan R. Rodríguez-Madoz, Alan Belicha‐Villanueva, Dabeiba Bernal‐Rubio, Joseph Ashour, Juan Ayllón, Ana Fernandez‐Sesma,
ABSTRACT Dengue virus (DENV) is the most prevalent arthropod-borne human virus, able to infect and replicate in human dendritic cells (DCs), inducing their activation and the production of proinflammatory cytokines. However, DENV can successfully evade the immune response in order to produce disease in humans. Several mechanisms of immune evasion have been suggested for DENV, most of them involving interference with type I interferon (IFN) signaling. We recently reported that DENV infection of human ...
Tópico(s): Viral Infections and Outbreaks Research
2010 - American Society for Microbiology | Journal of Virology
Joseph Ashour, Juliet Morrison, Maudry Laurent-Rolle, Alan Belicha‐Villanueva, Courtney R. Plumlee, Dabeiba Bernal‐Rubio, Katherine L. Williams, Eva Harris, Ana Fernandez‐Sesma, Christian Schindler, Adolfo Garcı́a-Sastre,
Dengue virus encodes several interferon antagonists. Among these the NS5 protein binds STAT2, a necessary component of the type I interferon signaling pathway, and targets it for degradation. We now demonstrate that the ability of dengue NS5 to associate with and degrade STAT2 is species specific. Thus, NS5 is able to bind and degrade human STAT2, but not mouse STAT2. This difference was exploited to demonstrate, absent manipulation of the viral genome, that NS5-mediated IFN antagonism is essential ...
Tópico(s): Virology and Viral Diseases
2010 - Cell Press | Cell Host & Microbe
Juan R. Rodríguez-Madoz, Dabeiba Bernal‐Rubio, Dorota Kaminski, K. L. Boyd, Ana Fernandez‐Sesma,
Dengue virus (DENV) infects human immune cells in vitro and likely infects dendritic cells (DCs) in vivo. DENV-2 productive infection induces activation and release of high levels of chemokines and proinflammatory cytokines in monocyte-derived DCs (moDCs), with the notable exception of alpha/beta interferon (IFN-alpha/beta). Interestingly, DENV-2-infected moDCs fail to prime T cells, most likely due to the lack of IFN-alpha/beta released by moDCs, since this effect was reversed by addition of exogenous ...
Tópico(s): Viral Infections and Outbreaks Research
2010 - American Society for Microbiology | Journal of Virology
Jun Yang, Sivakumar Paramasivam, Dabeiba Marulanda, Marcela Cataldi, María Luisa Tasayco, Tatyana Polenova,
Differentially isotopically enriched 1–73(13C,15N)/74–108(15N) and 1–73(15N)/74–108(13C,15N) Escherichia coli thioredoxin reassemblies prepared by fragment complementation were investigated by high-resolution magic angle spinning solid-state NMR spectroscopy. Nearly complete resonance assignments, secondary and tertiary structure analysis are reported for 1–73(13C,15N)/74–108(15N) reassembled thioredoxin. Temperature dependence of the dipolar-assisted rotational resonance (DARR) spectra reveals the ...
Tópico(s): Solid-state spectroscopy and crystallography
2007 - Wiley | Magnetic Resonance in Chemistry
Julius Clemence R. Hafalla, Urvashi Rai, Dabeiba Bernal‐Rubio, Ana Rodrı́guez, Fidel Zavala,
Immunity to Plasmodium liver stages in individuals in malaria-endemic areas is inextricably linked to concomitant blood-stage parasitemia. Although Plasmodium sporozoite infection induces measurable CD8+ T cell responses, the development of memory T cells during active erythrocytic infection remains uncharacterized. Using transgenic T cells, we assessed antigen-specific effector CD8+ T cell responses induced by normal (NorSpz) and radiation-attenuated (IrrSpz) Plasmodium yoelii sporozoites. The magnitude, ...
Tópico(s): Immunotherapy and Immune Responses
2007 - Oxford University Press | The Journal of Infectious Diseases
Irene Ramos, Dabeiba Bernal‐Rubio, Natasha D. Durham, Alan Belicha‐Villanueva, Anice C. Lowen, John Steel, Ana Fernandez‐Sesma,
Humans infected by the highly pathogenic H5N1 avian influenza viruses (HPAIV) present unusually high concentrations in serum of proinflammatory cytokines and chemokines, which are believed to contribute to the high pathogenicity of these viruses. The hemagglutinins (HAs) of avian influenza viruses preferentially bind to sialic acids attached through α2,3 linkages (SAα2,3) to the terminal galactose of carbohydrates on the host cell surface, while the HAs from human strains bind to α2,6-linked SA (SAα2, ...
Tópico(s): Immune Cell Function and Interaction
2011 - American Society for Microbiology | Journal of Virology
Dabeiba Adriana García Robayo,
Cancer of the uterine cervix (CC) is the second most common cancer in women worldwide. In Colombia, CC is the second most frequent cancer among the entire women population and the first among women aged between 15 and 44 years, with an estimated incidence of 24.9 cases/100,000 inhabitants. The main risk factor is infection with one or more high-risk human papillomavirus (HPV) types. The aim of this study was to estimate the genotype-specific prevalence of human papillomavirus (HPV) DNA in patients ...
Tópico(s): Bacteriophages and microbial interactions
2011 - | The Open Virology Journal
Julius Clemence R. Hafalla, Urvashi Rai, Alexandre Morrot, Dabeiba Bernal‐Rubio, Fidel Zavala, Ana Rodrı́guez,
Protective immune responses against malaria are induced by immunization with radiation-attenuated Plasmodium sporozoites. In contrast, non-viable, heat-killed sporozoites do not induce protection, emphasizing the requirement for live parasites to achieve effective immune responses. Using an experimental system with CD8+ T cells from T cell receptor-transgenic mice, we analyzed the primary CD8+ T cell responses elicited by heat-killed inactivated sporozoites. We found that the numbers of specific ...
Tópico(s): Immune Cell Function and Interaction
2006 - Wiley | European Journal of Immunology
Sebastián Aguirre, Ana M. Maestre, Sarah Pagni, Jenish Patel, Timothy J. Savage, Delia Gutman, Kevin Maringer, Dabeiba Bernal‐Rubio, Reed S. Shabman, Viviana Simon, Juan R. Rodríguez-Madoz, Lubbertus C. F. Mulder, Glen N. Barber, Ana Fernandez‐Sesma,
Dengue virus (DENV) is a pathogen with a high impact on human health. It replicates in a wide range of cells involved in the immune response. To efficiently infect humans, DENV must evade or inhibit fundamental elements of the innate immune system, namely the type I interferon response. DENV circumvents the host immune response by expressing proteins that antagonize the cellular innate immunity. We have recently documented the inhibition of type I IFN production by the proteolytic activity of DENV ...
Tópico(s): Viral Infections and Vectors
2012 - Public Library of Science | PLoS Pathogens
Irene Ramos, Elena Carnero, Dabeiba Bernal‐Rubio, Christopher W. Seibert, Liset Westera, Adolfo Garcı́a-Sastre, Ana Fernandez‐Sesma,
ABSTRACT The influenza virus nonstructural protein 1 (NS1) inhibits innate immunity by multiple mechanisms. We previously reported that NS1 is able to inhibit the production of type I interferon (IFN) and proinflammatory cytokines in human primary dendritic cells (DCs). Here, we used recombinant viruses expressing mutant NS1 from the A/Texas/36/91 and A/Puerto Rico/08/34 strains in order to analyze the contribution of different NS1 domains to its antagonist functions. We show that the polyadenylation ...
Tópico(s): Immune Response and Inflammation
2012 - American Society for Microbiology | Journal of Virology
Alan Belicha‐Villanueva, Juan R. Rodríguez-Madoz, Jad Maamary, Alina Baum, Dabeiba Bernal‐Rubio, Maria Minguito de la Escalera, Ana Fernandez‐Sesma, Adolfo Garcı́a-Sastre,
ABSTRACT Influenza A viruses containing the promoter mutations G3A/C8U in a given segment express increased levels of the corresponding viral protein during infection due to increased levels of mRNA or cRNA species. The replication of these recombinant viruses is attenuated, and they have an enhanced shedding of noninfectious particles and are incapable of antagonizing interferon (IFN) effectively. Our findings highlight the possibility of increasing influenza virus protein expression and the need ...
Tópico(s): Respiratory viral infections research
2012 - American Society for Microbiology | Journal of Virology
G Gabriel Rodríguez, G Gilberto Zapata,
... intrusive bodies outcropping from Pueblo Rico (Risaralda) until Dabeiba (Antioquia). Plutons's composition belong to a group ...
Tópico(s): Geological and Tectonic Studies in Latin America
2012 - National University of Colombia | Boletín de Ciencias de la Tierra
Dabeiba Marulanda, María Luisa Tasayco, Marcela Cataldi, Vilma Arriaran, Tatyana Polenova,
De novo site-specific 13C and 15N backbone and sidechain resonance assignments are presented for uniformly enriched E. coli thioredoxin, established using two-dimensional homo- and heteronuclear solid-state magic angle spinning NMR correlation spectroscopy. Backbone dihedral angles and secondary structure were derived from the statistical analysis of the secondary chemical shifts, and are in good agreement with solution values for the intact full-length thioredoxin, with the exception of a small ...
Tópico(s): Electron Spin Resonance Studies
2005 - American Chemical Society | The Journal of Physical Chemistry B
Dabeiba Marulanda, María Luisa Tasayco, Ann E. McDermott, Marcela Cataldi, Vilma Arriaran, Tatyana Polenova,
De novo site-specific backbone and side-chain resonance assignments are presented for U-15N(1−73)/U-13C,15N(74−108) reassembly of Escherichia coli thioredoxin by fragment complementation, determined using solid-state magic angle spinning NMR spectroscopy at 17.6 T. Backbone dihedral angles and secondary structure predicted from the statistical analysis of 13C and 15N chemical shifts are in general agreement with solution values for the intact full-length thioredoxin, confirming that the secondary ...
Tópico(s): Electron Spin Resonance Studies
2004 - American Chemical Society | Journal of the American Chemical Society
Irene Ramos, Florian Krammer, Rong Hai, Domingo Aguilera‐Garcia, Dabeiba Bernal‐Rubio, John Steel, Adolfo Garcı́a-Sastre, Ana Fernandez‐Sesma,
The recent human outbreak of H7N9 avian influenza A virus has caused worldwide concerns. Receptor binding specificity is critical for viral pathogenicity, and still not thoroughly studied for this emerging virus. Here, we evaluated the receptor specificity of the haemagglutinin (HA) of two human H7N9 isolates (A/Shanghai/1/13 and A/Anhui/1/13) through a solid-phase binding assay and a flow cytometry-based assay. In addition, we compared it with those from several HAs from human and avian influenza ...
Tópico(s): Respiratory viral infections research
2013 - Microbiology Society | Journal of General Virology
G Gabriel Rodríguez, María Isabel Arango,
... Cordillera Occidental, entre las fallas Cauca-Almaguer y Dabeiba-Pueblo Rico afl oran dos unidades volcanicas, que ...
Tópico(s): Geological and Geophysical Studies Worldwide
2013 - National University of Colombia | Boletín de Ciencias de la Tierra
Shuhei Taguwa, Kevin Maringer, Xiaokai Li, Dabeiba Bernal‐Rubio, Jennifer N. Rauch, Jason E. Gestwicki, Raul Andino, Ana Fernandez‐Sesma, Judith Frydman,
Summary Viral protein homeostasis depends entirely on the machinery of the infected cell. Accordingly, viruses can illuminate the interplay between cellular proteostasis components and their distinct substrates. Here, we define how the Hsp70 chaperone network mediates the dengue virus life cycle. Cytosolic Hsp70 isoforms are required at distinct steps of the viral cycle, including entry, RNA replication, and virion biogenesis. Hsp70 function at each step is specified by nine distinct DNAJ cofactors. Of ...
Tópico(s): Viral Infections and Outbreaks Research
2015 - Cell Press | Cell
Liliana Otero, Dabeiba Adriana García Robayo, Liseth Wilches-Buitrago,
Objective The objective of this study is to investigate the expression and concentration of ligand receptor activator of NFκB (RANKL) and osteoprotegerin (OPG) in human periodontal ligament (hPDL) with orthodontic forces of different magnitudes. Methods Right premolars in 32 patients were loaded with 4oz or 7oz of orthodontic force for 7 days. Left first premolars were not loaded. After 7 days, premolars were extracted for treatment as indicated. OPG and RANKL mRNA expressions were measured by quantitative ...
Tópico(s): Medical and Biological Sciences
2016 - SAGE Publishing | Gene Regulation and Systems Biology
Sebastián Aguirre, Priya Luthra, María Teresa Sánchez-Aparicio, Ana M. Maestre, Jenish Patel, Francise Lamothe, Anthony C. Fredericks, Shashank Tripathi, Tongtong Zhu, Jessica Pintado-Silva, Laurence G. Webb, Dabeiba Bernal‐Rubio, Alexander Solovyov, Benjamin Greenbaum, Viviana Simon, Christopher F. Basler, Lubbertus C. F. Mulder, Adolfo Garcı́a-Sastre, Ana Fernandez‐Sesma,
During the last few decades, the global incidence of dengue virus (DENV) has increased dramatically, and it is now endemic in more than 100 countries. To establish a productive infection in humans, DENV uses different strategies to inhibit or avoid the host innate immune system. Several DENV proteins have been shown to strategically target crucial components of the type I interferon system. Here, we report that the DENV NS2B protease cofactor targets the DNA sensor cyclic GMP-AMP synthase (cGAS) for ...
Tópico(s): HIV Research and Treatment
2017 - Nature Portfolio | Nature Microbiology
Rebecca E. Hamlin, Adeeb Rahman, Theodore Pak, Kevin Maringer, Ignacio Mena, Dabeiba Bernal‐Rubio, Uma Potla, Ana M. Maestre, Anthony C. Fredericks, El-ad David Amir, Andrew Kasarskis, Irene Ramos, Miriam Mérad, Ana Fernandez‐Sesma,
Dengue virus (DENV) is the most prevalent mosquito-borne virus causing human disease. Of the 4 DENV serotypes, epidemiological data suggest that DENV-2 secondary infections are associated with more severe disease than DENV-4 infections. Mass cytometry by time-of-flight (CyTOF) was used to dissect immune changes induced by DENV-2 and DENV-4 in human DCs, the initial targets of primary infections that likely affect infection outcomes. Strikingly, DENV-4 replication peaked earlier and promoted stronger ...
Tópico(s): Insect symbiosis and bacterial influences
2017 - American Society for Clinical Investigation | JCI Insight
George R. Young, Sandra Terry, Lara Manganaro, Álvaro Cuesta‐Domínguez, Gintaras Deikus, Dabeiba Bernal‐Rubio, Laura Campisi, Ana Fernandez‐Sesma, Robert Sebra, Viviana Simon, Lubbertus C. F. Mulder,
ABSTRACT Endogenous retroviruses (ERVs) occupy extensive regions of the human genome. Although many of these retroviral elements have lost their ability to replicate, those whose insertion took place more recently, such as the HML-2 group of HERV-K elements, still retain intact open reading frames and the capacity to produce certain viral RNA and/or proteins. Transcription of these ERVs is, however, tightly regulated by dedicated epigenetic control mechanisms. Nonetheless, it has been reported that ...
Tópico(s): HIV Research and Treatment
2017 - American Society for Microbiology | Journal of Virology
Louisa E. Wallace, Anthony C. Fredericks, Dabeiba Bernal‐Rubio, Andrew D. Davidson, Ana Fernandez‐Sesma, Kevin Maringer,
Aedes aegyptiis a vector mosquito of major public health importance, transmitting arthropod-borne viruses (arboviruses) such as chikungunya, dengue, yellow fever and Zika viruses. Wild mosquito populations are persistently infected at high prevalence with insect-specific viruses that do not replicate in vertebrate hosts. In experimental settings, acute infections with insect-specific viruses have been shown to modulate arbovirus infection and transmission in Ae. aegypti and other vector mosquitoes, ...
Tópico(s): Insect symbiosis and bacterial influences
2019 - Microbiology Society | Access Microbiology
Dabeiba Adriana García Robayo, Herlinto Alveiro Tupaz Erira, Fredy Gamboa, Andrey Moreno Torres, Andrés Ignacio Chala Galindo,
Abstract Introduction: Human papilloma virus (HPV) and oral bacteria capable of acetaldehyde production from ethanol, such as Streptococcus anginosus, Prevotella melaninogenica, and Fusobacterium naviforme are among oropharyngeal squamous cell carcinoma (OSCC) infectious risk factors. Objective: Determine associations with HPV and S. anginosus, P. melaninogenica, and F. naviforme in patients with and without OSCC. Methods: Presence of HPV and HPV-16 was determined in 26 patients with OSCC and 26 without ...
Tópico(s): Oral microbiology and periodontitis research
2019 - Fundação Odontológica de Ribeirão Preto | Brazilian Dental Journal
Laurence G. Webb, Jeury Veloz, Jessica Pintado-Silva, Tongtong Zhu, Margarita V. Rangel, Tinaye Mutetwa, L. Zhang, Dabeiba Bernal‐Rubio, Dania M. Figueroa, Lucía Carrau, Rafael Fenutría, Uma Potla, St Patrick Reid, Jacob S. Yount, Kenneth A. Stapleford, Sebastián Aguirre, Ana Fernandez‐Sesma,
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus known to cause epidemics resulting in predominantly symptomatic infections, which in rare cases cause long term debilitating arthritis and arthralgia. Significant progress has been made in understanding the roles of canonical RNA sensing pathways in the host recognition of CHIKV; however, less is known regarding antagonism of CHIKV by cytosolic DNA sensing pathways like that of cyclic GMP-AMP synthase (cGAS) and Stimulator of Interferon Genes ( ...
Tópico(s): Mosquito-borne diseases and control
2020 - Public Library of Science | PLoS Pathogens
... colombiano) enterrados en el cementerio Las Mercedes en Dabeiba, Colombia y su posible relación con bodegas, mejor ...
Tópico(s): Conflict, Peace, and Violence in Colombia
2022 - University of Alicante | Revista Mediterránea de Comunicación
Gabriel-Jaime Castañeda-Corzo, Luís-Felipe Infante-Rodríguez, Jean-Carlos Villamil-Poveda, Jairo Bustillo, Ángel Cid-Arregui, Dabeiba Adriana García Robayo,
To investigate the frequencies and bacterial load of three species of periodontal bacteria in samples from oropharyngeal cancer patients versus healthy individuals.This is a case-control study based on biopsies collected from tumor tissues obtained from patients with oropharyngeal squamous cell carcinoma between 2016 and 2017 and shed oral mucosal epithelial cells that were collected from controls using the Cepimax® brush, carrying out several brushings towards the posterior third edge of the tongue ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2023 - Elsevier BV | Heliyon
Rafael Fenutría, Kevin Maringer, Uma Potla, Dabeiba Bernal‐Rubio, Matthew J. Evans, Eva Harris, Adeeb Rahman, Ana Fernandez‐Sesma, Irene Ramos,
Zika and dengue virus (ZIKV and DENV) are two flaviviruses responsible for important vector-borne emerging infectious diseases. While there have been multiple DENV epidemics in the last decades, there have been fewer documented epidemics caused by ZIKV until recent years. Thus, our current knowledge about the biology of ZIKV, the disease, and the immune responses in humans is limited. Here, we used mass cytometry (CyTOF) to perform a detailed characterization of the innate immune responses elicited ...
Tópico(s): Malaria Research and Control
2021 - American Society for Microbiology | mSphere