Masato Yoshioka, Yuichi Sakaguchi, Daisuke Utsunomiya, Shinichiro Sonoda, Takeichi Tatsuta, Satoshi Ozawa, Yuichi Teramura, Keita Harada, Hideaki Kinugasa, Hiroyuki Okada,
Significance: Polyp size is important for selecting the surveillance interval or treatment policy. Nevertheless, it is challenging to accurately estimate the polyp size during endoscopy. An easy and cost-effective function to assist in polyp size estimation is required. Aim: To propose a virtual scale function for endoscopy and evaluate its performance and expected accuracy. Approach: An adaptive virtual scale behavior was demonstrated. The measurement error of the virtual scale along the distance ...
Tópico(s): Esophageal Cancer Research and Treatment
2021 - SPIE | Journal of Biomedical Optics
Hisahiro Hosogi, Masazumi Sakaguchi, Daisuke Yagi, Ryohei Onishi, Yasuhiro Hashimoto, Yoshiharu Sakai, Seiichiro Kanaya,
Tópico(s): Gastroesophageal reflux and treatments
2021 - Springer Science+Business Media | Langenbeck s Archives of Surgery
Nao Kazami, Masayoshi Sakaguchi, Daisuke Mizutani, Tatsuhiko Masuda, Satoshi Wakita, Fumitaka Oyama, Masao Kawakita, Yasusato Sugahara,
Chitin oligomers are of interest because of their numerous biologically relevant properties. To prepare chitin oligomers containing 4–6 GlcNAc units [(GlcNAc)4–6], α- and β-chitin were hydrolyzed with concentrated hydrochloric acid at 40 °C. The reactant was mixed with acetone to recover the acetone-insoluble material, and (GlcNAc)4–6 was efficiently recovered after subsequent water extraction. Composition analysis using gel permeation chromatography and MALDI-TOF mass spectrometry indicated that (GlcNAc) ...
Tópico(s): Polysaccharides and Plant Cell Walls
2015 - Elsevier BV | Carbohydrate Polymers
Shigeki Kiyonaka, Taketoshi Kajimoto, Reiko Sakaguchi, Daisuke Shinmi, Mariko Omatsu‐Kanbe, Hiroshi Matsuura, Hiromi Imamura, Takenao Yoshizaki, Itaru Hamachi, Takashi Morii, Yasuo Mori,
Tópico(s): ATP Synthase and ATPases Research
2013 - Nature Portfolio | Nature Methods
Morikatsu Yoshida, Shinya Shiraishi, Fumi Sakaguchi, Daisuke Utsunomiya, Kuniyuki Tashiro, Seiji Tomiguchi, Hirohisa Okabe, Toru Beppu, Hideo Baba, Yasuyuki Yamashita,
Tópico(s): Liver Disease and Transplantation
2012 - Springer Science+Business Media | Japanese Journal of Radiology
Morikatsu Yoshida, Shinya Shiraishi, Fumi Sakaguchi, Daisuke Utsunomiya, Kuniyuki Tashiro, Seiji Tomiguchi, Hirohisa Okabe, Toru Beppu, Hideo Baba, Yasuyuki Yamashita,
Tópico(s): Organ Transplantation Techniques and Outcomes
2012 - Springer Science+Business Media | Japanese Journal of Radiology
Kouji Tanimoto, Kurumi Suzuki, Eija Jokitalo, Noriko Sakai, Tomoaki Sakaguchi, Daisuke Tamura, Gourou Fujii, Kenji Aoki, Saya Takada, Ryuichi Ishida, Masako Tanabe, Hideaki Itoh, Yukio Yoneda, Miwa Sohda, Yoshio Misumi, Nobuhiro Nakamura,
The Yip1 domain family (YIPF) proteins are homologues of yeast Yip1p and Yif1p, which are proposed to function in ER to Golgi transport. Here, we report the characterization of YIPF3 and YIPF4, homologues of human Yif1p and Yip1p, respectively. Immunofluorescence and immuno-electron microscopy showed that both YIPF3 and YIPF4 are clearly concentrated in the cis-Golgi. While YIPF4 was detected as a single mobility form consistent with its predicted molecular weight, three different mobility forms ...
Tópico(s): Retinal Development and Disorders
2011 - Japan Society of Cell Biology | Cell Structure and Function
Jun Nakazawa, Keiji Isshiki, Toshiro Sugimoto, Shin‐ichi Araki, Shinji Kume, Yukiyo Yokomaku, Masami Chin‐Kanasaki, Masayoshi Sakaguchi, Daisuke Koya, Masakazu Haneda, Atsunori Kashiwagi, Takashi Uzu,
Diabetic patients are at higher risk of failure to recover after acute kidney injury, however, the mechanism and therapeutic strategies remain unclear. Erythropoietin is cytoprotective in a variety of non-haematopoietic cells. The aim of the present study was to clarify the mechanism of diabetes-related acceleration of renal damage after ischaemia-reperfusion injury and to examine the therapeutic potential of asialoerythropoietin, a non-haematopoietic erythropoietin derivative, against ischaemia- ...
Tópico(s): Acute Kidney Injury Research
2009 - Wiley | Nephrology
Naoko Deji, Shinji Kume, Shin‐ichi Araki, Mariko Soumura, Toshiro Sugimoto, Keiji Isshiki, Masami Chin‐Kanasaki, Masayoshi Sakaguchi, Daisuke Koya, Masakazu Haneda, Atsunori Kashiwagi, Takashi Uzu,
Metabolic syndrome has been reported to be associated with chronic kidney disease, but the mechanisms remain unclear. Although feeding of a high-fat diet (HFD) to C57BL/6 mice is reported to induce systemic metabolic abnormalities and subsequent renal injuries, such as albuminuria, similar to human metabolic syndrome, alterations in HFD-induced renal injuries have not been fully elucidated in detail. We therefore investigated the structural and functional changes in the kidneys of C57BL/6 mice on ...
Tópico(s): Dialysis and Renal Disease Management
2008 - American Physical Society | AJP Renal Physiology
Yasuko Sakurai‐Yamashita, Suehiro Sakaguchi, Daisuke Yoshikawa, Naonobu Okimura, Yuichi Masuda, Shigeru Katamine, Masami Niwa,
This study was designed to examine the function of cellular prion protein and prion protein-like protein/Doppel, in transient ischemia-related neuronal death in the hippocampus. Two different lines of mice devoid of cellular prion protein, Zrch I Prnp0/0 and Ngsk Prnp0/0, were used. The former lacks cellular prion protein whereas the latter ectopically expresses prion protein-like protein/Doppel in the brain in the absence of cellular prion protein. Mice were subjected to 10 min-occlusion of the ...
Tópico(s): Alzheimer's disease research and treatments
2005 - Elsevier BV | Neuroscience
Takehito Kato, Makoto Fujimoto, T Kado, Shohei Sakaguchi, Daisuke Kosugi, R. Shiratuchi, Wataru Takashima, Keiichi Kaneto, Shuzi Hayase,
Dye-sensitized solar cells (DSCs) are solidified with gelators containing polyvinylpyridine and 1,2,4,5-tetra(bromomethyl)benzene. The photoconversion efficiencies are improved by new additives. LiI and -butylpyridine are commonly added in electrolytes for increasing short-circuit current (Jsc) and open-circuit voltage (Voc). These additives inhibit our gel electrolyte precursors from solidifying. We found that new additives, combinations of acetic acid, and methylpyrimidine or methylbenzimidazole, ...
Tópico(s): Electrowetting and Microfluidic Technologies
2005 - Institute of Physics | Journal of The Electrochemical Society
Satoshi Sakaguchi, Daisuke Kikuchi, Yasutaka Ishii,
Abstract NaBrO3 combined with NaHSO3 was found to be an excellent oxidizing reagent of alcohols, diols, and ethers under mild conditions. A variety of aliphatic and cyclic diols were selectively oxidized with satisfactory yields to the corresponding hydroxy ketones and/or diketones, which are difficult to selectively prepare due to a concomitant formation of cleaved products. For example, 2-hydroxycyclohexanone and 1,2-cyclohexanedione were selectively formed by allowing 1,2-cyclohexanediol to react ...
Tópico(s): Inorganic and Organometallic Chemistry
1997 - Oxford University Press | Bulletin of the Chemical Society of Japan
Masaomi Ikeda, Kazumasa Matsumoto, Kazushige Sakaguchi, Daisuke Ishii, Ken‐ichi Tabata, Kazuhiro Kurosawa, Shinji Urakami, Toshikazu Okaneya, Masatsugu Iwamura,
Background The role of lymph node dissection (LND) for upper tract urothelial carcinoma (UTUC) patients remains controversial. The aim of this study was to evaluate the effect of LND on clinical outcomes during radical nephroureterectomy (RNU) and to determine prognostic factors of survival. Patients and Methods From 1985 to 2013, 404 patients with UTUC underwent RNU; 5 patients who received neoadjuvant chemotherapy were excluded. Among them, 182 (46%) were pathologically negative for lymph node metastasis ( ...
Tópico(s): Urological Disorders and Treatments
2017 - Elsevier BV | Clinical Genitourinary Cancer
Toshikazu Sakaguchi, Daisuke Nojiri, Tamotsu Hashimoto,
Tópico(s): Synthesis and properties of polymers
2007 - Springer Science+Business Media | Polymer Bulletin
Toshimasa Ishida, Masaaki Sakaguchi, Daisuke Yamamoto, Masatoshi Inoue, Kunihiro Kitamura, Kazunori Hanada, Takanao Sadatome,
In order to establish the conformational characteristics of a cysteine protease inhibitor, the crystal and solution conformations of loxistatin have been determined by X-ray crystallographic and 1H n.m.r. spectroscopic analyses. The molecules were arranged in the crystal as a series of infinite parallel β-sheet structures formed via intermolecular N-H ⋯ O hydrogen bonds. The loxistatin molecule has a flattened, curved conformation, which appears to be energetically stable. Similar conformations of ...
Tópico(s): Phytochemistry and biological activities of Ficus species
1988 - Royal Society of Chemistry | Journal of the Chemical Society. Perkin transactions II
Tetsuya Sakaguchi, Daisuke Ishikawa, Hiroshi Nomura, Norio Matsuki, Yuji Ikegaya,
In rats and mice, the hippocampus lies beneath higher than 1 mm of the neocortex. This anatomical feature makes it difficult to experimentally access the hippocampus from the surface of the brain in vivo. This problem may be solved by surgical removal of the cortical tissue above the hippocampus; however, it has not been examined whether this 'hippocampal window' surgery preserves the normal hippocampal function. We bilaterally aspirated the posterior parietal cortex above the dorsal hippocampus ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2012 - Lippincott Williams & Wilkins | Neuroreport
Maho Aoyama, Yukihiro Sakaguchi, Daisuke Fujisawa, Tatsuya Morita, Asao Ogawa, Yoshiyuki Kizawa, Satoru Tsuneto, Yasuo Shima, Mitsunori Miyashita,
Bereaved individuals are known to have greater health risks, such as insomnia, excessive alcohol intake, and depression. However, few studies have investigated the relation between these risks and bereavement outcomes, namely complicated grief (CG) and major depressive disorder (MDD). This study aimed to assess the relation between insomnia, changes in alcohol consumption, and CG or MDD.A cross-sectional, self-report questionnaire survey was conducted between May and July 2014 on 20 acute hospitals, ...
Tópico(s): Palliative Care and End-of-Life Issues
2020 - Elsevier BV | Journal of Affective Disorders
Satoshi Okumura, Takayuki Kajikawa, Koki Yano, Kazuhiko Sakaguchi, Daisuke Kosumi, Hideki Hashimoto, Shigeo Katsumura,
Fucoxanthin is an essential pigment for the light-harvesting of aquatic algae. It exhibits high energy transfer efficiencies to Chl a (>80%) as well as peridinin (>95%). In order to verify the generality and specificity of the noticeable observation on the ICT excited energy state character, which was found in the study of peridinin, we achieved the straightforward synthesis of a series of fucoxanthin short-chain derivatives via the modified-Julia olefination with the aldehyde half segment possessing ...
Tópico(s): Algal biology and biofuel production
2013 - Elsevier BV | Tetrahedron Letters
Arito Sakaguchi, Hide Sakaguchi, Daisuke Nishiura, Masao Nakatani, Shingo Yoshida,
It has long been believed impossible to estimate maximum paleo‐elastic stress in rocks, because elastic strain disappears by elastic rebound when a rock is sampled. Plastic strain, on the other hand, leaves a permanent change in rocks even after stress is relaxed. For example, calcite records plastic strain as stress‐dependent intracrystalline deformation by mechanical twinning. What happens if a rock contains a small amount of calcite bounded by silicate‐rich matrix is elastically loaded? To answer ...
Tópico(s): Geotechnical and Geomechanical Engineering
2011 - American Geophysical Union | Geophysical Research Letters
Mototsugu Tanaka, Mayumi Idei, Hiroshi Sakaguchi, Ryosuke Kato, Daisuke Sato, Kenji Sawanobori, Shuichi Kawarasaki, Toshiyuki Hata, Asako Yoshizaki, Miki Nakamura, Mutsuhiro Ikuma,
The Sakigake designation system (Sakigake) has been launched to encourage the pioneered development of innovative new medical products for the effective treatment of severe illness in Japan, which allows leveraging the several advantages in prioritized consultation, rapid review, premium drug pricing and extended data-protection period. We retrospectively analysed the Sakigake products including drugs and regenerative medical products to clarify the achievements and the future issues in this system. ...
Tópico(s): Biomedical Ethics and Regulation
2021 - Wiley | British Journal of Clinical Pharmacology
Tatsuma Sakaguchi, Sohei Satoi, Daisuke Hashimoto, Tomohisa Yamamoto, So Yamaki, Satoshi Hirooka, Mitsuaki Ishida, Tsukasa Ikeura, Kentaro Inoue, Mitsugu Sekimoto,
We advocated carbohydrate antigen (CA) 19-9 ≥ 150 U/mL and tumor size ≥30 mm as "high-risk markers" for predicting unresectability among patients with radiologically resectable (R) or borderline resectable (BR) pancreatic ductal adenocarcinoma (PDAC). The main aim is to establish a risk scoring system for occult abdominal metastasis (OAM) in R/BR PDAC.Predictors of OAM were investigated retrospectively in an experiment cohort from 2006 to 2018. The proposed risk scoring system was validated in another cohort ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2021 - Wiley | Journal of Hepato-Biliary-Pancreatic Sciences
Hikaru Miura, Takashi Ishimaru, Yukari Ito, Yuichi Kurihara, Shigeyoshi Otosaka, Aya Sakaguchi, Kazuhiro Misumi, Daisuke Tsumune, Atsushi Kubo, Shogo Higaki, Jota Kanda, Yoshio Takahashi,
Abstract A part of the radiocaesium from the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident was emitted as glassy, water-resistant caesium-bearing microparticles (CsMPs). Here, we isolated and investigated seven CsMPs from marine particulate matter and sediment. From the elemental composition, the 134 Cs/ 137 Cs activity ratio, and the 137 Cs activity per unit volume results, we inferred that the five CsMPs collected from particulate matter were emitted from Unit 2 of the FDNPP, whereas the ...
Tópico(s): Radioactivity and Radon Measurements
2021 - Nature Portfolio | Scientific Reports
Mototsugu Tanaka, Mayumi Idei, Hiroshi Sakaguchi, Ryosuke Kato, Daisuke Sato, Kenji Sawanobori, Shuichi Kawarasaki, Toshiyuki Hata, Asako Yoshizaki, Miki Nakamura, Mutsuhiro Ikuma,
The Pharmaceuticals and Medical Devices Agency (PMDA) has approved hundreds of new drugs in recent years. We retrospectively analyzed the new drugs approved in Japan from 2008 to 2019, and identify the first‐in‐world approvals and clarify the current drug lag. The new drug and the drug lag were defined as a drug with a new active substance and a difference between the approval date in Japan and the international birth date, respectively. Among 400 new drugs approved in Japan during the last 12 years, ...
Tópico(s): Pharmaceutical studies and practices
2020 - Wiley | Clinical Pharmacology & Therapeutics
Yusuke Kita, Hironobu Sakaguchi, Yoichi Hoshimoto, Daisuke Nakauchi, Yasuhito Nakahara, Jean‐François Carpentier, Sensuke Ogoshi, Kazushi Mashima,
Abstract Direct amination of allylic alcohols with primary and secondary amines catalyzed by a system made of [Ni(1,5‐cyclooctadiene) 2 ] and 1,1′‐bis(diphenylphosphino)ferrocene was effectively enhanced by adding n Bu 4 NOAc and molecular sieves, affording the corresponding allyl amines in high yield with high monoallylation selectivity for primary amines and high regioselectivity for monosubstituted allylic alcohols. Such remarkable additive effects of n Bu 4 NOAc were elucidated by isolating and ...
Tópico(s): Asymmetric Synthesis and Catalysis
2015 - Wiley | Chemistry - A European Journal
Taichi Sakaguchi, Goro Matsumiya, Daisuke Yoshioka, Shigeru Miyagawa, Hiroyuki Nishi, Yasushi Yoshikawa, Satsuki Fukushima, Shunsuke Saito, Takayoshi Ueno, Yoshiki Sawa,
Background: The DuraHeart left ventricular assist device (LVAD) is the world's first approved magnetically levitated implantable centrifugal pump. We report our initial experience with the DuraHeart as a bridge to heart transplantation. Methods and Results: Between 2008 and 2011, 23 patients (17 males; mean age 35 years, range 16–53 years) with endstage heart failure underwent implantation with the DuraHeart LVAD at Osaka University Hospital. Of those, 7 underwent conversion surgery from a Nipro paracorporeal ...
Tópico(s): Fuel Cells and Related Materials
2013 - Japanese Circulation Society | Circulation Journal
Yuki Tanaka, Shinji Kume, Shin‐ichi Araki, Keiji Isshiki, Masami Chin‐Kanasaki, Masayoshi Sakaguchi, Toshiro Sugimoto, Daisuke Koya, Masakazu Haneda, Atsunori Kashiwagi, Hiroshi Maegawa, Takashi Uzu,
As renal lipotoxicity can lead to chronic kidney disease (CKD), we examined the role of peroxisome proliferator-activated receptor (PPAR)-α, a positive regulator of renal lipolysis. Feeding mice a high-fat diet induced glomerular injury, and treating them with fenofibrate, a PPARα agonist, increased the expression of lipolytic enzymes and reduced lipid accumulation and oxidative stress in glomeruli, while inhibiting the development of albuminuria and glomerular fibrosis. In mice given an overload ...
Tópico(s): Alcohol Consumption and Health Effects
2011 - Elsevier BV | Kidney International
Toshiro Sugimoto, Naoko Deji, Shinji Kume, Norihisa Osawa, Masayoshi Sakaguchi, Keiji Isshiki, Daisuke Koya, Atsunori Kashiwagi,
We present a case of a 38-year-old Japanese man with Wegener's granulomatosis complicated with pulmonary-renal syndrome, i.e., diffuse pulmonary hemorrhage and rapidly progressive renal glomerulonephritis. As this is a life-threatening condition, we promptly initiated plasma exchange with intravenous methylprednisolone therapy. Diffuse pulmonary hemorrhage and renal failure were markedly improved. This case merits presentation because there are few clinical studies of the treatment of Wegener's ...
Tópico(s): Urticaria and Related Conditions
2007 - The Japanese Society of Internal Medicine | Internal Medicine
Naoki Ohmiya, Ichiro Hirata, Hirotsugu Sakamoto, Toshifumi Morishita, Eiko Saito, Katsuyoshi Matsuoka, Tadanobu Nagaya, Shinji Nagata, Miyuki Mukae, Koji Sano, Takayoshi Suzuki, Ken‐ichi Tarumi, Seiji Shimizu, Kousaku Kawashima, Toshifumi Hibi∥, Naoki Ohmiya, Ichiro Hirata, Hirotsugu Sakamoto, Toshifumi Morishita, Eiko Saito, Katsuyoshi Matsuoka, Tadanobu Nagaya, Shinji Nagata, Miyuki Mukae, Koji Sano, Takayoshi Suzuki, Ken‐ichi Tarumi, Seiji Shimizu, Kousaku Kawashima, Toshifumi Hibi∥, Akimichi Imamura, Yohei Minato, Kazuhiro Matsueda, Go Kuwata, Masahiro Sakaguchi, Daisuke Saito, Sakae Mikami, Mitsuhiro Fujishiro, Shigehiko Fujii, Junji Umeno, Kenji Aoi, Daisuke Nutahara, Fukunori Kinjo, Mikihiro Fujiya, Keita Harada, Mitsunobu Matsushita, Toshimi Chiba, Yutaka Sasaki, Shinji Tanaka, Yoshiaki Aomi, Kunio Kasugai, Shojiro Yamamoto, Nobuaki Yagi, Tomoo Yoshie, Masaki Yoshida, Shin Fukudo, Takanori Yamada, Kensuke Kitsugi, Shigeru Kuriyama, Soichiro Miura, Yoshiya Fujimoto, Yasumasa Niwa, Takashi Nishikawa, Kiyotaka Okawa, Makoto Sanomura, Masanao Nakamura, Tsutomu Mizoshita,
Pneumatosis intestinalis (PI) is a rare condition characterized by gas collection in the intestinal wall. We aimed to determine the etiology and affected segments associated with complications, treatment, and outcome.We conducted a multicenter epidemiological survey using a standardized data collection sheet in Japan. Complicating PI was defined as strangulation or bowel necrosis, bowel obstruction, adynamic ileus, sepsis, shock, and massive gastrointestinal bleeding requiring blood transfusion.We ...
Tópico(s): Esophageal and GI Pathology
2022 - BioMed Central | BMC Gastroenterology
Inoue Mizuki, Hiroki Itô, Michimasa Yamasaki, Shigeru Fukumoto, Yuuki Okamoto, Masaya Katsuki, Keitaro Fukushima, Masaru Sakai, Shota Sakaguchi, Daisuke Fujiki, Hikaru Nakagawa, Masae I. Ishihara, Atsushi Takayanagi,
Deer overabundance is a contributing factor in the degradation of plant communities and ecosystems worldwide. The management and conservation of the deer-affected ecosystems requires us to urgently grasp deer population trends and to identify the factors that affect them. In this study, we developed a Bayesian state–space model to estimate the population dynamics of sika deer (Cervus nippon) in a cool-temperate forest in Japan, where wolves (Canis lupus hodophilax) are extinct. The model was based ...
Tópico(s): Wildlife-Road Interactions and Conservation
2020 - Public Library of Science | PLoS ONE
Ayaka Yamaguchi, Tamotsu Hashimoto, Hideyuki Uematsu, Michio Urushisaki, Toshikazu Sakaguchi, Atsushi Takamura, Daisuke Sasaki,
Tópico(s): Polymer crystallization and properties
2019 - Springer Nature | Polymer Journal