Mădălina Tudose, Elena Maria Anghel, Daniela C. Culiță, Simona Şomăcescu, José Maria Calderón-Moreno, Victoriţa Tecuceanu, Florea Dumitraşcu, Olguţa Drăcea, Marcela Popa, Luminița Măruțescu, Coralia Bleoţu, Carmen Curuțiu, Mariana Carmen Chifiriuc,
In this work, we present a simple, two-stage method for the preparation of new and efficient antimicrobial hybrid systems, based on isoniazid and pyrazine-2-carbohydrazide tuberculostatic agents covalently linked to graphene oxide. In the first step, the carboxyl groups of graphene oxide are activated by transforming them into the corresponding acid chloride groups, which, in the second step, will react with the amino groups of the two drugs. Pyrazine-2-carbohydrazide was obtained from pyrazinoic ...
Tópico(s): Nanoplatforms for cancer theranostics
2018 - Elsevier BV | Applied Surface Science
Radu Anghel, Daniela Jitaru, Laurenţiu Bădescu, Magda Bădescu, Manuela Ciocoiu,
Many studies have highlighted the tumoricidal properties of some natural peptides known to have antimicrobial virtues. Also, the increasingly higher resistance to conventional antibiotics has become a global public health issue, and the need for new antibiotics has stimulated interest in finding and synthesizing new antimicrobial peptides, which may also be used as chemotherapeutic agents. Relying on the literature, the purpose of our in vitro research was to assess the tumoricidal potential of ...
Tópico(s): Aquaculture disease management and microbiota
2013 - Hindawi Publishing Corporation | BioMed Research International
Victor Fruth, Mónica Popa, José Maria Calderón-Moreno, Elena Maria Anghel, Daniela Berger, M. Gärtner, Mihai Anastasescu, Petre Osiceanu, Maria Zaharescu,
Tópico(s): Dielectric properties of ceramics
2007 - Elsevier BV | Journal of the European Ceramic Society
Carmen Adella Sîrbu, Dana-Claudia Thompson, C Pleşa, M. Vasile, Dragoş Cătălin Jianu, Marian Mitrică, Daniela Anghel, Constantin Ștefani,
Multiple sclerosis is an increasingly prevalent disease, representing the leading cause of non-traumatic neurological disease in Europe and North America. The most common symptoms include gait deficits, balance and coordination impairments, fatigue, spasticity, dysphagia and an overactive bladder. Neurorehabilitation therapeutic approaches aim to alleviate symptoms and improve the quality of life through promoting positive immunological transformations and neuroplasticity. The purpose of this study ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2022 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Remus Orășan, Ioan Mihai Pațiu, Daniela Anghel, Cezarina Bejan, Ligia Iosub, Camelia Totolici, Mariana Pop, Carmen Turcea, Cristina Teodoru, Olga Hilda Orășan, Ina Maria Kacsó, Mirela Gherman Caprioara,
Tópico(s): Electrolyte and hormonal disorders
2012 - Springer Science+Business Media | International Urology and Nephrology
Daniela Anghel, Carmen Adella Sîrbu, Elena-Mădălina Hoinoiu, Oana-Georgiana Petrache, Cristina-Florentina Pleșa, Maria Magdalena Negru, Florentina Ioniţă‐Radu,
It is a well-known fact that disruptions in the immune system and systemic inflammation are associated with accelerated atherosclerosis in rheumatoid arthritis (RA) patients. Elevated levels of tumor necrosis factor α (TNF-α), a major pro-inflammatory cytokine, are involved in endothelial cell activation of medium and large arteries, leading to increased endothelial permeability, generation of superoxide anion radical and hydrogen peroxide, and decreased availability of nitric oxide (NO). The present ...
Tópico(s): Systemic Sclerosis and Related Diseases
2021 - Spandidos Publishing | Experimental and Therapeutic Medicine
Ioana Mădălina Zota, Cristina Andreea Adam, Dragoș Traian Marius Marcu, Cristian Stătescu, Radu Andy Sascău, Larisa Anghel, Daniela Boișteanu, Mihai Roca, Corina Lucia Dima Cozma, Alexandra Maștaleru, M. Constantin, Elena Andreea Moaleș, Florin Mitu,
Obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse, chronic hypoxia and a proinflammatory phenotype. The purpose of our study was to evaluate readily available inflammatory biomarkers (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), red cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), WBC-to-MPV ratio (WMR) and lymphocyte-to-C-reactive protein ratio ( ...
Tópico(s): Inflammatory Biomarkers in Disease Prognosis
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Amir A. Mbonde, Cumara B. O’Carroll, Adriana Octaviana Dulămea, Daniela Anghel, Brian W. Chong, Oana Dumitrașcu,
Transient ischemic attack (TIA) is defined as a transient episode of neurological dysfunction resulting from focal brain, spinal cord, or retinal ischemia, without associated infarction. Consequently, a TIA encompasses amaurosis fugax (AF) that is a term used to denote momentary visual loss from transient retinal ischemia. In this review, we use the word TIA to refer to both cerebral TIAs (occurring in the brain) and AF (occurring in the retina). We summarize the key components of a comprehensive evaluation ...
Tópico(s): Retinal and Optic Conditions
2022 - Lippincott Williams & Wilkins | Asia-Pacific Journal of Ophthalmology
Ionelia Țăranu, Gina Cecilia Pistol, Andrei Cristian Anghel, Daniela Eliza Marin, Cristina Valeria Bulgaru,
(1) The present study tested in vitro the capacity of a fermented rapeseed meal extract to reduce medicinal ZnO, which will be banned at the EU level from 2023 onwards because of its potential to cause environmental pollution and the development of Zn resistance in gut bacteria. Rapeseed meal could be an important ZnO substitute as it has antioxidant/radical scavenging properties due to its content of bioactive compounds (e.g., polyphenols). (2) Protein array and flow cytometry were used to detect ...
Tópico(s): Protein Hydrolysis and Bioactive Peptides
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Radu Anghel, Daniela Jitaru, Laurenţiu Bădescu, Manuela Ciocoiu, Magda Bădescu,
The aim of the present in vitro study was to assess the tumoricidal potential of the following natural peptides belonging to the Cecropin family, namely Cecropin A and B, on a series of tumour cell lines: MDA-MB-231 (breast adenocarcinoma) and M14K (human mesothelioma). The experimental results reveal that the cytotoxic effects of the two peptides depend on their concentration. Their efficiency is significant at 120 μM concentrations and it persists even at 60 μM concentrations. The effects were insignificant ...
Tópico(s): Polydiacetylene-based materials and applications
2014 - Scientific Research Publishing | Journal of Biomedical Science and Engineering
Daniela Anghel, Carmen Adella Sîrbu, Oana-Georgiana Petrache, Daniela Opriş-Belinski, Maria Magdalena Negru, Violeta‐Claudia Bojincă, Cristina Florentina Pleșa, Florentina Ioniţă‐Radu,
Videocapillaroscopy is a simple, non-invasive investigation that allows the "in vivo" study of the nailfold capillaries. This method is inexpensive, easily accepted by patients and the results can be easily interpreted. It is mainly used in patients with Raynaud's phenomenon and systemic sclerosis, but this examination can also be performed on patients who are suspected of having microcirculation alterations, such as rheumatoid arthritis and psoriatic arthritis. It may aid in the diagnosis, evaluation ...
Tópico(s): Dermatological and Skeletal Disorders
2023 - Multidisciplinary Digital Publishing Institute | Diagnostics
Luminița Predoană, Elena Mădălina Ciobanu, Gabriela Petcu, Silviu Preda, Jeanina Pandele-Cuşu, Elena Maria Anghel, Simona Petrescu, Daniela C. Culiță, Adriana Băran, Vasile-Adrian Surdu, Bogdan Ștefan Vasile, Adelina Ianculescu,
The tin-doped TiO2 powders obtained by sol-gel and microwave-assisted sol-gel methods were investigated. The synthesis took place in a basic medium (pH 10, ammonium hydroxide, 25%) starting from tetrabutyl orthotitanate in its parental alcohol. In the case of the dopant, Tin(II) 2-ethylhexanoate as SnO2 precursor was used in the amount of 1, 2, or 4 mol % SnO2. Based on thermal analysis data, the powders were thermally treated in air, at 500 °C. The comparative investigation of the structure and morphology ...
Tópico(s): Gas Sensing Nanomaterials and Sensors
2023 - Multidisciplinary Digital Publishing Institute | Catalysts
Irina Atkinson, Viorica Pârvulescu, Jeanina Pandele Cusu, Elena Maria Anghel, Mariana Voicescu, Daniela C. Culiță, Simona Şomăcescu, Cornel Munteanu, M. Šćepanović, Zoran V. Popović, Victor Fruth,
Tópico(s): TiO2 Photocatalysis and Solar Cells
2018 - Elsevier BV | Journal of Photochemistry and Photobiology A Chemistry
Daniela-Mădălina Ciucă Anghel, Gabriela Viorela Nițescu, Andreea Taisia Tiron, Claudia Maria Guțu, Daniela Luiza Baconi,
Aim. Drug abuse and addiction are major public health concerns, with millions of people worldwide affected by the negative consequences of drug use. To better understand this complex issue, a review was conducted to examine the mechanisms of action and effects of drugs of abuse, including their acute and chronic effects, the symptoms of abstinence syndrome, as well as their cardiovascular impacts. Methods. The analyzed data were obtained after surveying an electronic database, namely PubMed, with ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2023 - Multidisciplinary Digital Publishing Institute | Molecules
C Pleşa, Alina Jijie, Gabriela Simona Toma, Aurelian Emil Ranetti, Aida Mihaela Manole, Ruxandra Rotaru, Ionuț Caloianu, Daniela Anghel, Adriana Octaviana Dulămea,
Cerebral venous thrombosis (CVT) is a rare type of stroke, with a complex clinical presentation that can make it a diagnostic challenge for the swift initiation of anticoagulation. When a hemorrhagic transformation is added, therapeutic management becomes even more complex. We describe a series of four cases, aged between 23 and 37 years old, with cerebral venous thrombosis. They were admitted to our clinic between 2014 and 2022. All cases presented significant challenges in either diagnostic, therapeutic ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2023 - Multidisciplinary Digital Publishing Institute | Life
Viorica Muşat, Nicolae Stanică, Elena Maria Anghel, Irina Atkinson, Daniela C. Culiță, Silviu Poloşan, Lenuța Crintea, Alina Cantaragiu Ceoromila, Cristian-Teodor Buruiană, Oana Carp,
In recent years, iron oxides-based nanostructured composite materials are of particular interest for the preparation of multifunctional thin films and membranes to be used in sustainable magnetic field adsorption and photocatalysis processes, intelligent coatings, and packing or bio-medical applications. In this paper, superparamagnetic iron oxide (core)-silica (shell) nanoparticles suitable for thin films and membrane functionalization were obtained by co-precipitation and ultrasonic-assisted sol- ...
Tópico(s): Minerals Flotation and Separation Techniques
2022 - Multidisciplinary Digital Publishing Institute | Membranes
Florentina Ioniţă‐Radu, Iulia-Nadine Nicolau, Oana-Georgiana Petrache, Maria-Laura Groșeanu, Violeta‐Claudia Bojincă, Maria-Magdalena Negru, Săndica Bucurică, Daniela Anghel,
Rheumatoid arthritis (RA) is an independent osteoporosis risk factor. Biologic and immunosuppressive treatment, and levels of homocysteine and 25-OH vitamin D may influence the trabecular bone score (TBS) in RA patients. We aimed to compare the effects of biological (b) and conventional synthetic (cs) disease-modifying anti-rheumatic drugs (DMARDs) on TBS in patients with RA and hyperhomocysteinemia (HHcy) or 25-OH vitamin D deficiency. Patients who had tests conducted for trabecular bone score, bone ...
Tópico(s): Spondyloarthritis Studies and Treatments
2024 - Multidisciplinary Digital Publishing Institute | Life
Marilena-Viorica Hovaneț, Emma Adriana Ozon, Elena Moroșan, Oana Cristina Șeremet, Eliza Oprea, Elisabeta‐Irina Geană, Adriana Iuliana Anghel, Carmellina Daniela Bădiceanu, Ligia Elena Duțu, C. Stoicescu, Eugenia Nagodă, Robert Ancuceanu,
Ziziphus jujuba Mill. (jujube) is a well-known medicinal plant with pronounced wound healing properties. The present study aimed to establish the chemical composition of the lyophilized ethanolic extract from Romanian Ziziphus jujuba leaves and to evaluate the healing and anti-inflammatory properties of a newly developed lipophilic ointment containing 10% dried jujube leaves extract. The ultra-High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry method was used, ...
Tópico(s): Ginseng Biological Effects and Applications
2022 - Multidisciplinary Digital Publishing Institute | Life
Cristian‐Mihail Niculae, Ana-Maria-Jennifer Anghel, Eliza-Daniela Militaru, Laura‐Georgiana Țîrlescu, Mihai Lazăr, Adriana Hristea,
(1) Background: We aimed to describe the clinical and imaging characteristics of patients diagnosed with pulmonary artery thrombosis (PAT) despite receiving anticoagulation with low-molecular-weight heparin (LMWH). (2) Methods: We retrospectively studied all hospitalized COVID-19 adult patients diagnosed with PAT between March 2020 and December 2021, who received LMWH for ≥72 h until the diagnosis of PAT. Acute PAT was confirmed by a CT pulmonary angiogram. (3) Results: We included 30 severe and critical ...
Tópico(s): Long-Term Effects of COVID-19
2022 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Florian Antonescu, Ioana Butnariu, Florentina Melania Cojocaru, Daniela Anghel, Eliza Damaris Mihai, Sorin Tuță,
BACKGROUND:Ramsay Hunt syndrome is a rare form of herpes zoster caused by the reactivation of the varicella-zoster virus in the geniculate ganglion. The main clinical manifestations are peripheral facial palsy, vesicular rash in the ear, and ipsilateral auricular pain, and sometimes vertigo. COVID-19 is a new multisystemic infectious disease that, in addition to common respiratory manifestations, it is known to affect the immune system, primarily depressing cellular immunity. CASE REPORT:A 54-year- ...
Tópico(s): Trigeminal Neuralgia and Treatments
2021 - International Scientific Information Inc. | American Journal of Case Reports
Mihai Lazăr, Ecaterina Constanța Barbu, Cristina Emilia Chițu, Ana-Maria-Jennifer Anghel, Cristian‐Mihail Niculae, Eliza-Daniela Manea, Anca-Cristina Damalan, A. Bel, R. Patrascu, Adriana Hristea, Daniela Adriana Ion,
Background and Objectives: SARS-CoV-2 has an extensive tissue tropism due to its ability to attach to the surfaces of cells through different receptors, leading to systemic complications. In this article, we aim to present the prevalence of pericardial effusions in patients with severe COVID-19, to identify the risk factors/predictors for pericardial involvement, and to evaluate its impact on overall mortality. Materials and Methods: We enrolled 100 patients with severe COVID-19 in our observational ...
Tópico(s): COVID-19 Clinical Research Studies
2022 - Multidisciplinary Digital Publishing Institute | Medicina
Ioana Mădălina Zota, Cristian Stătescu, Radu Andy Sascău, Mihai Roca, Larisa Anghel, Ovidiu Mitu, Cristina Mihaela Ghiciuc, Daniela Boișteanu, Răzvan Anghel, Sebastian Cozma, Lucia Corina Dima-Cozma, Florin Mitu,
Background: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial stiffness could be assessed using the Arteriograph (TensioMed, Budapest, Hungary) to detect early modifications induced by continuous positive airway therapy (CPAP) in reversing this detrimental vascular remodeling. Arterial stiffness is increasingly acknowledged as a major cardiovascular risk factor and a marker of subclinical hypertension-mediated ...
Tópico(s): Cardiovascular and Diving-Related Complications
2021 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Mihai Lazăr, Ecaterina Constanța Barbu, Cristina Emilia Chițu, Ana-Maria-Jennifer Anghel, Cristian‐Mihail Niculae, Eliza-Daniela Manea, Anca-Cristina Damalan, A. Bel, R. Patrascu, Adriana Hristea, Daniela Adriana Ion,
Background and Objectives: The severe forms of SARS-CoV-2 pneumonia are associated with acute hypoxic respiratory failure and high mortality rates, raising significant challenges for the medical community. The objective of this paper is to present the importance of early quantitative evaluation of radiological changes in SARS-CoV-2 pneumonia, including an alternative way to evaluate lung involvement using normal density clusters. Based on these elements we have developed a more accurate new predictive ...
Tópico(s): COVID-19 and healthcare impacts
2022 - Multidisciplinary Digital Publishing Institute | Medicina
Săndica Bucurică, Mihaela Lupanciuc, Florentina Ioniţă‐Radu, Ion Ștefan, Alice Elena Munteanu, Daniela Anghel, Mariana Jinga, Elena Laura Gaman,
Hepatocellular adenomas are benign endothelial tumors of the liver, mostly associated with female individual users of estrogen-containing medications. However, the precise factors underlying the selective development of hepatic adenomas in certain females remain elusive. Additionally, the conventional profile of individuals prone to hepatic adenoma is changing. Notably, male patients exhibit a higher risk of malignant progression of hepatocellular adenomas, and there are instances where hepatic ...
Tópico(s): Pharmacological Effects of Natural Compounds
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Andrei Bogdan Stoian, Cristina Surdu-Bob, A. Anghel, Daniela Ioniţă, Ioana Demetrescu,
The paper presents the investigation of a series of silver-incorporated diamond-like carbon (Ag-DLC) coatings with increasing Ag content on Ti50Zr and deposited using high voltage anodic plasma (HVAP). The coatings surface properties were analyzed with scanning electron microscope (SEM), atomic force microscope (AFM), and contact angle determinations. Electrochemical tests were performed in Afnor artificial saliva and evaluated by potentiodynamic polarization and electrochemical impedance spectroscopy. ...
Tópico(s): Lubricants and Their Additives
2019 - Multidisciplinary Digital Publishing Institute | Coatings
Narcis Anghel, Maria Valentina Dinu, Mirela‐Fernanda Zaltariov, Daniela Pamfil, Iuliana Spiridon,
Herein we present a new biomaterial based on cellulose, collagen and sodium alginate which served as a matrix for the incorporation of bioactive substances with antioxidant properties. Compared with pure cellulose hydrogels, the compressive strength and the elastic modulus of cellulose-collagen-alginate hydrogels were significantly enhanced, thus the compressive strength increased from 0.256 kPa to 6.91 kPa, while the elastic modulus increased from 0.0023 kPa to 0.115 kPa at 30% strain level. The ...
Tópico(s): Hydrogels: synthesis, properties, applications
2021 - Elsevier BV | International Journal of Biological Macromolecules
Ana-Maria-Jennifer Anghel, Cristian‐Mihail Niculae, Eliza-Daniela Manea, Mihai Lazăr, Mara Popescu, Anca-Cristina Damalan, A. Bel, Iulia-Maria Nedelcu, R. Patrascu, Adriana Hristea,
(1) Background: We aimed to analyze the characteristics associated with the in-hospital mortality, describe the early CT changes expressed quantitatively after tocilizumab (TOC), and assess TOC timing according to the oxygen demands. (2) Methods: We retrospectively studied 101 adult patients with severe COVID-19, who received TOC and dexamethasone. The lung involvement was assessed quantitatively using native CT examination before and 7−10 days after TOC administration. (3) Results: The in-hospital ...
Tópico(s): Hematological disorders and diagnostics
2022 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Gabriela Petcu, Elena Maria Anghel, Simona Şomăcescu, Silviu Preda, Daniela C. Culiță, Sorin Mocanu, Mădălina Ciobanu, Viorica Pârvulescu,
The Ti/hierarchical zeolites Y were obtained by direct and post synthesis methods and loaded with Fe(III) by ion-exchange and impregnation resulting Fe-Ti/hierarchical zeolites Y photocatalysts. The synthesized materials were characterized by XRD, SEM microscopy, N2 physical adsorption, Raman, UV-Vis and XPS and EPR spectroscopy. XRD patterns evidenced the crystalline structure of the zeolite Y in all materials, excepting the samples with higher Fe content. The presence of anatase was evidenced ...
Tópico(s): Water Quality Monitoring and Analysis
2019 - American Scientific Publishers | Journal of Nanoscience and Nanotechnology
Corina Daniela Ene, Amalia-Elena Anghel, Monica Neagu, Ilinca Nicolae,
Background . There are several circulatory biomarkers that are involved in forecasting the clinical outcome of cutaneous melanoma. Serum/plasma vitamin D status is one of the markers intensively studied in this type of cutaneous cancer. The combination of validated serum biomarkers (like LDH) with new biomarkers such as IL‐8, angiogenic factor, and vitamin D is still at the dawn of research. Hence, we are aiming to establish the predictive power of inflammatory biomarkers, such as IL‐8, and metabolic ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2015 - Hindawi Publishing Corporation | Mediators of Inflammation
Cristina-Florentina Pleșa, Diana Maria Chiţimuș, Carmen Adella Sîrbu, Monica Marilena Țânțu, Minerva Ghinescu, Daniela Anghel, Florentina Ioniţă‐Radu,
Secondary thrombotic thrombocytopenic purpura (TTP) due to interferon beta-1a intramuscular (im) treatment is an uncommon adverse effect with only a few cases in multiple sclerosis patients reported worldwide. TTP together with haemolytic uremic syndrome (HUS) are classic forms of thrombotic microangiopathy, characterized by small-vessel platelet micro-thrombi that manifest clinically in a similar manner. Most common signs and symptoms include bruises and ecchymosis, neurologic symptoms and renal impairment. ...
Tópico(s): Blood groups and transfusion
2022 - Multidisciplinary Digital Publishing Institute | Life