Kan Yu, Yue Zhang, Danni Li, Carlos Montenegro, Priyan Malarvizhi Kumar,
Waste disposal was a significant challenge faced by the community and government. Customers buy and use goods that produce a considerable amount of waste. Waste management is a major problem since the number of consumers increased due to high waste generation. This has resulted in a huge amount of waste, which calls for enormous waste-management policies. Reduce; Reuse, Recycle, and Recover are the tools to reduce the adverse implications of retailing and manufacturing on the environment. In this ...
Tópico(s): Healthcare and Environmental Waste Management
2020 - Elsevier BV | Environmental Impact Assessment Review
J. C. M. Danni, José Carlos Gaspar,
Tópico(s): Geography and Environmental Studies
1994 - | Geochimica Brasiliensis
Produção Nacional
Revisado por pares
Paulo Fernando Dotto Bau, Claiton H.D. Bau, Guido Aranha Rosito, Waldomiro Carlos Manfrói, Flávio Danni Fuchs,
Cardiovascular diseases are among the worldwide leading causes of shorter life expectancy and loss of quality of life. Thus, any influence of diet or life habits on the cardiovascular system may have important implications for public health. Most world populations consume alcoholic beverages. Since alcohol may have both protective and harmful effects on cardiovascular health, the identification of biochemical mechanisms that could explain such paradoxical effects is warranted. The vascular endothelium ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
2007 - Elsevier BV | Alcohol
Danni Li, Bobby G. Poe, Marian Navrátil, Carlos T. Moraes, Edgar A. Arriaga,
Reactive oxygen species (ROS) that are produced by mitochondria are released toward the mitochondrial matrix or the intermembrane space. Each ROS pool is likely involved in different cellular mechanisms and damage. Unfortunately, it is difficult to distinguish the provenance and effects of ROS. Here we introduce a method to semiquantitate the steady-state levels of superoxide produced in the matrix of mitochondria. Superoxide produced during cellular respiration is capable of oxidizing hydroethidine, ...
Tópico(s): Metabolism and Genetic Disorders
2006 - Elsevier BV | Free Radical Biology and Medicine
Produção Nacional
Revisado por pares
Jaqueline Neves Lubianca, Carlo Sasso Faccin, Flávio Danni Fuchs,
The objective of the study was to assess the association between systolic and diastolic blood pressure (SBP and DBP) and the use of oral contraceptives (OC) in hypertensive women. In a prospective cross-sectional study, we evaluated 171 women who were referred to the Hypertension Outpatient Clinic of Hospital de Clínicas de Porto Alegre; 66 current users of OC, 26 users of other contraceptive methods and 79 women who were not using contraception. The average of six blood pressure readings was used ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2003 - Elsevier BV | Contraception
Produção Nacional
Revisado por pares
E M Krieger, Luciano F. Drager, D Giorgi, Alexandre C. Pereira, José Augusto Barreto‐Filho, Armando R. Nogueira, José Geraldo Mill, Paulo A. Lotufo, Celso Amodeo, Marcelo C. Batista, Luiz Carlos Bodanese, Antonio C.C Carvalho, Iran Castro, Hilton Chaves, Eduardo A. Costa, Gílson Soares Feitosa, Roberto Jorge da Silva Franco, Flávio Danni Fuchs, Armênio Costa Guimarães, Paulo César Brandão Veiga Jardim, Carlos Alberto Machado, Maria Eliane Campos Magalhães, Décio Mion, Raimundo Marques Nascimento, Fernando Nobre, Antônio Cláudio Lucas da Nóbrega, Antônio Luiz Pinho Ribeiro, Carlos R.M. Rodrigues‐Sobrinho, Antônio Felipe Sanjuliani, Maria do Carmo Borges Teixeira, José Eduardo Krieger, Alessandro Betito, Diogo D.F. Moia, Silvia Beatriz Paulino Cavasin de Souza, Hilton de Castro Chaves Júnior,
The aim of this study is to compare spironolactone versus clonidine as the fourth drug in patients with resistant hypertension in a multicenter, randomized trial. Medical therapy adherence was checked by pill counting. Patients with resistant hypertension (no office and ambulatory blood pressure [BP] monitoring control, despite treatment with 3 drugs, including a diuretic, for 12 weeks) were randomized to an additional 12-week treatment with spironolactone (12.5–50 mg QD) or clonidine (0.1–0.3 mg BID). ...
Tópico(s): Cardiovascular Syncope and Autonomic Disorders
2018 - Lippincott Williams & Wilkins | Hypertension
Produção Nacional
Revisado por pares
Felipe Costa Fuchs, Jorge P. Ribeiro, Flávio Danni Fuchs, Marco Vugman Wainstein, Luis Carlos Corsetti Bergoli, Rodrigo Vugman Wainstein, Vanessa Ligocki Zen, Alessandra Cristina Kerkhoff, Leila Beltrami Moreira, Sandra Cristina Pereira Costa Fuchs,
Background: The importance of coronary anatomy in predicting cardiovascular events is well known. The use of traditional anatomical scores in routine angiography, however, has not been incorporated to clinical practice. SYNTAX score (SXscore) is a scoring system that estimates the anatomical extent of coronary artery disease (CAD). Its ability to predict outcomes based on a baseline diagnostic angiography has not been tested to date. Objective: To evaluate the performance of the SXscore in predicting ...
Tópico(s): Coronary Interventions and Diagnostics
2016 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Simonetta Camandola, Manuela Aragno, Juan Carlos Cutrìn, Elena Tamagno, Oliviero Danni, Elena Chiarpotto, Maurizio Parola, Gabriella Leonarduzzi, Fiorella Biasi, Giuseppe Poli,
Experimental acute intoxication by prooxidant haloalkanes produces marked stimulation of hepatic lipid peroxidation and cytolysis, which is followed by tissue regeneration. Our aim was to clarify the role of oxidative imbalance in the activation of the redox-sensitive transcription factor, activator protein-1 (AP-1), which is involved in tissue repair. Rats were poisoned with a very low concentration of carbon tetrachloride, given alone or in combination with another hepatotoxin, 1,2-dibromoethane, ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
1999 - Elsevier BV | Free Radical Biology and Medicine
Produção Nacional
José Carlos Gaspar, José C.M. Danni,
The volcanic province of Santo Antonio da Barra located in the southwestern portion of Goias is of Cretaceous age (± 85,8 m.y.), and comprises a heterogeneous sequence of analcitic rocks (pyroclastic and flows), locally capped by flows, tuffs, and agglomerates of silicocarbonatitic composition. Rests of volcanic structures and a great number of pypes and vents formed by fourchites and melamonchiquites are found tectonically controlled by NW-trending faults. They are regarded as differentiated hypoabyssal ...
Tópico(s): Geochemistry and Geologic Mapping
1981 - Sociedade Brasileira de Geologia | Brazilian Journal of Geology
Produção Nacional
Revisado por pares
Flávio Danni Fuchs, Sandra Cristina Pereira Costa Fuchs, Leila Beltrami Moreira, Miguel Gus, Antônio Cláudio Lucas da Nóbrega, Carlos Eduardo Poli‐de‐Figueiredo, Décio Mion, Luiz A. Bortoloto, Fernanda Marciano Consolim‐Colombo, Fernando Nobre, Eduardo Barbosa Coelho, José Fernando Vilela-Martin, Heitor Moreno, Evandro José Cesarino, Roberto Jorge da Silva Franco, Andréa Araújo Brandão, Marcos Roberto de Sousa, Antônio Luiz Pinho Ribeiro, Paulo César Brandão Veiga Jardim, Abrahão Afiune Neto, Luiz César Nazário Scala, Marco Mota, Hilton Chaves, João Guilherme Bezerra Alves, Dário Celestino Sobral Filho, Ricardo Pereira e Silva, José Albuquerque de Figueiredo Neto, Maria Cláudia Irigoyen, Iran Castro, André Avelino Steffens, Rosane Paixão Schlatter, Renato Gorga Bandeira de Mello, Francisca Mosele, Flávia Ghizzoni, Otávio Berwanger,
Blood pressure (BP) within pre-hypertensive levels confers higher cardiovascular risk and is an intermediate stage for full hypertension, which develops in an annual rate of 7 out of 100 individuals with 40 to 50 years of age. Non-drug interventions to prevent hypertension have had low effectiveness. In individuals with previous cardiovascular disease or diabetes, the use of BP-lowering agents reduces the incidence of major cardiovascular events. In the absence of higher baseline risk, the use of ...
Tópico(s): Sodium Intake and Health
2011 - Springer Science+Business Media | Trials
Produção Nacional
Revisado por pares
Daniele Botelho Vinholes, Ione M. F. Melo, Carlos Alberto Machado, Hilton Chaves, Flávio Danni Fuchs, Sandra Cristina Pereira Costa Fuchs,
Background . Dietary pattern plays a causative role in the rising of noncommunicable diseases. The SESI ( Serviço Social da Indústria ) study was designed to evaluate risk factors for noncommunicable diseases. We aimed to describe food items consumed by Brazilian workers and to assess their association with socioeconomic status. Methods . Cross-sectional study was carried out among Brazilian industrial workers, selected by multistage sampling, from 157 companies. Interviews were conducted at the work place ...
Tópico(s): Global Public Health Policies and Epidemiology
2012 - Hindawi Publishing Corporation | The Scientific World JOURNAL
Ye Chen, Danni Wang, Jonathan Liu,
Various confocal microscope architectures have been developed for in vivo tissue imaging, including single-axis confocal (SAC) and dual-axis confocal (DAC) configurations utilizing both point-scanning (PS) and line-scanning (LS) approaches. While it is known that these design variations lead to tradeoffs in imaging performance, a quantitative comparison of the imaging performance of these configurations in highly turbid media would be of value. Here, we perform Monte Carlo simulations to evaluate the ...
Tópico(s): Advanced Fluorescence Microscopy Techniques
2012 - Optica Publishing Group | Optics Letters
Produção Nacional
Revisado por pares
Nadine Clausell, Flávio Danni Fuchs, Waldomiro Carlos Manfrói, Jorge Pinto Ribeiro,
Tópico(s): Healthcare during COVID-19 Pandemic
2004 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Flávio Danni Fuchs, Luiz César Nazário Scala, José Fernando Vilela-Martin, Renato Gorga Bandeira de Mello, Francisca Mosele, Paul K. Whelton, Carlos Eduardo Poli‐de‐Figueiredo, Paulo Ricardo de Alencastro, Ricardo Pereira e Silva, Miguel Gus, Luiz Aparecido Bortolotto, Rosane Paixão Schlatter, Evandro José Cesarino, Iran Castro, José Albuquerque de Figueiredo Neto, Hilton Chaves, André Avelino Steffens, João Guilherme Bezerra Alves, Andréa Araújo Brandão, Marcos Roberto de Sousa, Paulo César Brandão Veiga Jardim, Leila Beltrami Moreira, Roberto Silva Franco, Marco Mota Gomes, Abrahão Afiune Neto, Felipe Costa Fuchs, Dário Celestino Sobral Filho, Antônio Cláudio Lucas da Nóbrega, Fernando Nobre, Otávio Berwanger, Sandra Cristina Pereira Costa Fuchs,
To compare the blood pressure (BP)-lowering efficacy of a chlorthalidone/amiloride combination pill with losartan, during initial management of stage I hypertension.In a randomized, double-blind, controlled trial, 655 participants were followed for 18 months in 21 Brazilian academic centers. Trial participants were adult volunteers aged 30-70 years with stage I hypertension (BP 140-159 or 90-99 mmHg) following 3 months of a lifestyle intervention. Participants were randomized to 12.5/2.5 mg of chlorthalidone/ ...
Tópico(s): Renal function and acid-base balance
2016 - Lippincott Williams & Wilkins | Journal of Hypertension
Produção Nacional
Fernanda Cigainski Lisbinski, Carlos Eduardo Balestrin Flores, Danni Maísa da Silva, Ramiro Pereira Bisognin, Robson Evaldo Gehlen Bohrer,
Os consórcios públicos são de grande importância para a gestão pública, já que contribuem incentivando os municípios a adotarem esta ferramenta como uma forma de melhorar a prestação de serviços públicos e, consequentemente, a qualidade de vida da população regional. No presente trabalho objetivou-se analisar a importância do Consórcio Intermunicipal de Gestão de Resíduos Sólidos (CIGRES), localizado no município de Seberi - Rio Grande do Sul (RS), no desenvolvimento regional. Para isso buscou-se investigar ...
Tópico(s): Business and Management Studies
2020 - UNIVERSIDADE DO SUL DE SANTA CATARINA | Revista Gestão & Sustentabilidade Ambiental
Produção Nacional
Revisado por pares
Weimar Kunz Sebba Barroso, Cibele Isaac Saad Rodrigues, Luiz Aparecido Bortolotto, Marco Antônio Mota Gomes, Andréa Araújo Brandão, Audes D. M. Feitosa, Carlos Alberto Machado, Carlos Eduardo Poli‐de‐Figueiredo, Celso Amodeo, Décio Mion, Eduardo Costa Duarte Barbosa, Fernando Nobre, Isabel Cristina Britto Guimarães, José Fernando Vilela-Martin, Juan Carlos Yugar‐Toledo, Maria Eliane Campos Magalhães, Mário Fritsch Neves, Paulo César Brandão Veiga Jardim, Roberto Dischinger Miranda, Rui Póvoa, Sandra Cristina Pereira Costa Fuchs, Alexandre Alessi, Alexandre Jorge Gomes de Lucena, Álvaro Avezum, Ana Luíza Lima Sousa, Andrea Pio-Abreu, Andrei C. Spósito, Ângela Maria Geraldo Pierin, Annelise Machado Gomes de Paiva, A Spinelli, Armando da Rocha Nogueira, N Ludovico, Bruna Eibel, C. L. M. Forjaz, Cláudia Regina de Oliveira Zanini, Cristiane Bueno de Souza, Dilma do Socorro Moraes de Souza, Eduardo Augusto Fernandes Nilson, Elisa Franco de Assis Costa, Elizabete Viana de Freitas, Elizabeth da Rosa Duarte, Elizabeth Silaid Muxfeldt, Emilton Lima Júnior, Érika Maria Gonçalves Campana, Evandro José Cesarino, Fabiana Angelo Marques, Fábio Argenta, Fernanda Marciano Consolim‐Colombo, Fernanda Spadotto Baptista, Fernando Antônio de Almeida, Flávio Borelli, Flávio Danni Fuchs, Frida Liane Plavnik, Gil F. Salles, Gílson Soares Feitosa, Giovânio Vieira da Silva, Grazia Maria Guerra, Heitor Moreno, Helius Carlos Finimundi, Isabela de Carlos Back, João Bosco Oliveira, João Roberto Gemelli, José Geraldo Mill, JM Ribeiro, Leda Lotaif, L COSTA, Lucélia Batista Neves Cunha Magalhães, Luciano F. Drager, Luis Cuadrado Martín, Luiz César Nazário Scala, Madson Q. Almeida, MMG Gowdak, Márcia Regina Simas Torres Klein, Marcus Vinícius Bolívar Malachias, Maria Cristina Caetano Kuschnir, Maria Eliete Pinheiro, Mário Henrique Elesbão de Borba, Osni Moreira, Oswaldo Passarelli, Otávio Rizzi Coelho, Priscila Valverde de Oliveira Vitorino, Renault Mattos Ribeiro, Roberto Esporcatte, Roberto Jorge da Silva Franco, Rodrigo Pinto Pedrosa, Rogério Andrade Mulinari, Rogério Baumgratz de Paula, Rogério Toshiro Passos Okawa, Ronaldo Fernandes Rosa, Sandra L. Amaral, Sebastião Rodrigues Ferreira Filho, Sérgio Kaiser, Thiago Veiga Jardim, Vanildo da Silva Guimarães Neto, Vera Hermina Kalika Koch, Wille Oigman, Wilson Nadruz,
Content 1. Definition, Epidemiology, and Primary Prevention 528 1.1 Definition of Hypertension 528 […] Brazilian Guidelines of Hypertension – 2020
Tópico(s): Cardiovascular Health and Disease Prevention
2021 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Hyung Park, Thaddeus Tarpey, Mengling Liu, Keith Goldfeld, Yinxiang Wu, Danni Wu, Yi Li, Jinchun Zhang, Dipyaman Ganguly, Yogiraj Ray, Shekhar Ranjan Paul, Prasun Bhattacharya, Artur Belov, Yin Huang, Carlos H. Villa, Richard A. Forshee, Nicole Verdun, Hyunah Yoon, Anup Agarwal, Ventura Simonovich, Paula Scibona, Leandro Burgos Pratx, Waldo Belloso, C. Avendaño, Katharine J. Bar, Rafael F. Duarte, Priscilla Y. Hsue, Anne F. Luetkemeyer, Geert Meyfroidt, André Moraes Nicola, Aparna Mukherjee, Mila B. Ortigoza, Liise-anne Pirofski, Bart Rijnders, Andrea B. Troxel, Elliott M. Antman, Eva Petkova,
Importance Identifying which patients with COVID-19 are likely to benefit from COVID-19 convalescent plasma (CCP) treatment may have a large public health impact. Objective To develop an index for predicting the expected relative treatment benefit from CCP compared with treatment without CCP for patients hospitalized for COVID-19 using patients' baseline characteristics. Design, Setting, and Participants This prognostic study used data from the COMPILE study, ie, a meta-analysis of pooled individual patient ...
Tópico(s): COVID-19 Impact on Reproduction
2022 - American Medical Association | JAMA Network Open
Produção Nacional
Revisado por pares
Daniele Botelho Vinholes, Sérgio Luiz Bassanesi, Hilton Chaves, Carlos Alberto Machado, Ione M. F. Melo, Flávio Danni Fuchs, Sandra Cristina Pereira Costa Fuchs,
Background Exposure to risk factors for hypertension may be influenced by the characteristics of the workplace, where workers spend most of their daily time. Objectives To evaluate the association between features of the companies, particularly the presence of facilities to provide meals, and of population characteristics and the prevalence of hypertension, taking into account individual risk factors for hypertension. Material and methods This multilevel analysis was based on a cross-sectional study ...
Tópico(s): Obesity, Physical Activity, Diet
2017 - BMJ | BMJ Open
Produção Nacional
Revisado por pares
Flávio Danni Fuchs, Sandra Cristina Pereira Costa Fuchs, Carlos Eduardo Poli‐de‐Figueiredo, José Albuquerque de Figueiredo Neto, Luiz César Nazário Scala, José Fernando Vilela-Martin, Leila Beltrami Moreira, Hilton Chaves, Marco Mota Gomes, Marcos Roberto de Sousa, Ricardo Pereira e Silva, Iran Castro, Evandro José Cesarino, Ana Luíza Lima Sousa, João Guilherme Bezerra Alves, André Avelino Steffens, Andréa Araújo Brandão, Luiz Aparecido Bortolotto, Abrahão Afiune Neto, Antônio Cláudio Lucas da Nóbrega, Roberto Silva Franco, Dário Celestino Sobral Filho, Fernando Nobre, Rosane Paixão Schlatter, Miguel Gus, Caroline Nespolo de David, Leticia Rafaelli, Guilhermo Prates Sesin, Otávio Berwanger, Paul K. Whelton,
To determine the effectiveness of low-dose diuretic therapy to achieve an optimal level of blood pressure (BP) in adults with prehypertension.The PREVER-prevention trial was a randomized, parallel, double-blinded, placebo-controlled trial, with 18 months of follow-up, conducted at 21 academic medical centers in Brazil. Of 1772 individuals evaluated for eligibility, 730 volunteers with prehypertension who were aged 30-70 years, and who did not reach optimal blood pressure after 3 months of lifestyle ...
Tópico(s): Nutritional Studies and Diet
2017 - Lippincott Williams & Wilkins | Journal of Hypertension
Carlos Rondón, Hun-Goo Lee, Anna Lappala, Danni Wang, Verónica Noches, Montserrat Olivares‐Costa, Marcela Sjöberg, Jeannie T. Lee, Marı́a Estela Andrés,
Abstract RCOR1 is a known transcription repressor that recruits and positions LSD1 and HDAC1/2 on chromatin to erase histone methylation and acetylation. However, there is currently an incomplete understanding of RCOR1’s range of localization and function. Here, we probe RCOR1’s distribution on a genome-wide scale and unexpectedly find that RCOR1 is predominantly associated with transcriptionally active genes. Biochemical analysis reveals that RCOR1 associates with RNA Polymerase II (POL-II) during ...
Tópico(s): RNA modifications and cancer
2022 - Nature Portfolio | Nature Communications
G. Sansoè, Manuela Aragno, Raffaella Mastrocola, Juan Carlos Cutrìn, S. Silvano, Giulio Mengozzi, Antonina Smedile, F. Rosina, Oliviero Danni, M. Rizzetto,
Neutral endopeptidase degrades atrial natriuretic peptide (ANP) and bradykinin and may generate endothelin-1 from big-endothelin. In advanced cirrhosis, sodium retention is accompanied by elevated plasma ANP levels, and infusion of ANP causes hypotension, but in normal humans increasing the concentration of ANP through the inhibition of neutral endopeptidase, localized in renal proximal tubule cells, causes natriuresis without any arterial pressure drop. The purpose of this study was the assessment ...
Tópico(s): Heart Failure Treatment and Management
2006 - American Physical Society | AJP Renal Physiology
Manuela Aragno, Juan Carlos Cutrìn, Raffaella Mastrocola, Maria-Giulia Perrelli, Francesca Restivo, Giuseppe Poli, Oliviero Danni, Giuseppe Boccuzzi,
Oxidative stress and kidney dysfunction due to ischemia/reperfusion in rat: Attenuation by dehydroepiandrosterone. Background The pathogenesis of ischemia/reperfusion (I/R) involves generation of reactive oxygen and nitrogen species. This in vivo study investigates the effect of dehydroepiandrosterone (DHEA), a physiologic steroid with antioxidant properties, on oxidative balance and renal dysfunctions induced by monolateral I/R. Methods Normal and DHEA-treated rats (4mg/day × 21 days, orally) were subjected ...
Tópico(s): Hormonal Regulation and Hypertension
2003 - Elsevier BV | Kidney International
Produção Nacional
Revisado por pares
Renné Gusmão Busnello, Raquel Melchior, Carlo Sasso Faccin, Daniela Vanessa Vettori, Juliano Gueno Petter, Leila Beltrami Moreira, Flávio Danni Fuchs,
To determine the characteristics associated with the dropout of patients followed up in a Brazilian out patient clinic specializing in hypertension.Planned prospective cohort study of patients who were prescribed an antihypertensive treatment after an extensive initial evaluation. The following parameters were analyzed: sex, age, educational level, duration of disease, pressure level used for classifying the patient, previous treatment, physical activity, smoking, alcohol consumption, familial history ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2001 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Flávio Danni Fuchs, Sandra Cristina Pereira Costa Fuchs, Leila Beltrami Moreira, Miguel Gus, Antônio Cláudio Lucas da Nóbrega, Carlos Eduardo Poli‐de‐Figueiredo, Décio Mion, Luiz Aparecido Bortolotto, Fernanda Marciano Consolim‐Colombo, Fernando Nobre, Eduardo Barbosa Coelho, José Fernando Vilela-Martin, Heitor Moreno, Evandro José Cesarino, Roberto Jorge da Silva Franco, Andréa Araújo Brandão, Marcos Roberto de Sousa, Antônio Luiz Pinho Ribeiro, Paulo César Brandão Veiga Jardim, Abrahão Afiune Neto, Luiz César Nazário Scala, Marco Mota, Hilton Chaves, João Guilherme Bezerra Alves, Dário Celestino Sobral Filho, Ricardo Pereira e Silva, José Albuquerque de Figueiredo Neto, Maria Cláudia Irigoyen, Iran Castro, André Avelino Steffens, Rosane Paixão Schlatter, Renato Gorga Bandeira de Mello, Francisca Mosele, Flávia Ghizzoni, Otávio Berwanger,
Cardiovascular disease is the leading cause of death in Brazil, and hypertension is its major risk factor. The benefit of its drug treatment to prevent major cardiovascular events was consistently demonstrated. Angiotensin-receptor blockers (ARB) have been the preferential drugs in the management of hypertension worldwide, despite the absence of any consistent evidence of advantage over older agents, and the concern that they may be associated with lower renal protection and risk for cancer. Diuretics ...
Tópico(s): Renin-Angiotensin System Studies
2011 - Springer Science+Business Media | Trials
Francesco Patti, Silvia Messina, Claudio Solaro, Maria Pia Amato, Roberto Bergamaschi, Simona Bonavita, Roberto Bruno Bossio, Vincenzo Brescia Morra, Gianfranco Costantino, Paola Cavalla, Diego Centonze, Giancarlo Comi, Salvatore Cottone, Maura Danni, Ada Francia, Alberto Gajofatto, Claudio Gasperini, Angelo Ghezzi, Alfonso Iudice, Giacomo Lus, Giorgia Teresa Maniscalco, Maria Giovanna Marrosu, Manuela Matta, Massimiliano Mirabella, E. Montanari, Carlo Pozzilli, Marco Rovaris, Edoardo Sessa, Daniele Spitaleri, Maria Trojano, Paola Valentino, Mario Zappia,
Background The approval of 9-δ-tetrahydocannabinol and cannabidiol (THC:CBD) oromucosal spray (Sativex) for the management of treatment-resistant multiple sclerosis (MS) spasticity opened a new opportunity for many patients. The aim of our study was to describe Sativex effectiveness and adverse events profile in a large population of Italian patients with MS in the daily practice setting. Methods We collected data of all patients starting Sativex between January 2014 and February 2015 from the mandatory Italian ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2016 - BMJ | Journal of Neurology Neurosurgery & Psychiatry
Produção Nacional
Letícia Aparecida Barufi Fernandes, Elizabeth do Espírito Santo Cestário, Luciana Neves Cosenso-Martin, José Fernando Vilela-Martin, Juan Carlos Yugar‐Toledo, Flávio Danni Fuchs,
Background: Hypertension reduction strategies use blood pressure in the brachial artery as the primary endpoint. Individuals who achieve the target blood pressure reduction with antihypertensive treatment have residual cardiovascular risk attributed to the difference in pressure between the aorta and brachial artery. Antihypertensive treatment affects the intrinsic properties of the vascular wall and arterial stiffness markers and consequently the central pressure. Recent publications stress the ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2016 - | Cardiology Research
Produção Nacional
Revisado por pares
Flávio Danni Fuchs, Luiz César Nazário Scala, José Fernando Vilela-Martin, Paul K. Whelton, Carlos Eduardo Poli‐de‐Figueiredo, Ricardo Pereira e Silva, Miguel Gus, Luiz Aparecido Bortolotto, Fernanda Marciano Consolim‐Colombo, Rosane Paixão Schlatter, Evandro José Cesarino, Iran Castro, José Albuquerque de Figueiredo Neto, Hilton Chaves, André Avelino Steffens, João Guilherme Bezerra Alves, Andréa Araújo Brandão, Marcos Roberto de Sousa, Paulo César Brandão Veiga Jardim, Leila Beltrami Moreira, Roberto Silva Franco, Marco M. Gomes, Abrahão Afiune Neto, Felipe Costa Fuchs, Dário Celestino Sobral Filho, Antônio Cláudio Lucas da Nóbrega, Fernando Nobre, Otávio Berwanger, Sandra Cristina Pereira Costa Fuchs,
To compare the blood pressure (BP)-lowering efficacy of a chlorthalidone/amiloride combination pill with losartan, during initial management of JNC 7 Stage I hypertension in patients with type 2 diabetes mellitus.In an a priori subgroup analysis of a randomized, double-blind, controlled trial, volunteers aged 30-70 years, with stage I hypertension and diabetes mellitus, were randomized to 12.5/2.5 mg of chlorthalidone/amiloride (N = 47) or 50 mg of losartan (N = 50), and followed for 18 months in 21 clinical ...
Tópico(s): Nutritional Studies and Diet
2020 - Springer Science+Business Media | Acta Diabetologica
Produção Nacional
Revisado por pares
Claudio Coimbra Teixeira, Carlos Augusto Rava, Paula Mallman da Silva, Raquel Melchior, Rodrigo Argenta, Fabio Anselmi, Claudia Rejane Chiarel Almeida, Flávio Danni Fuchs,
The use of alternative therapies to treat diabetes, including teas prepared with different vegetables, is widespread in Brazil. In Porto Alegre, a southern city of Brazil, the tea prepared from leaves of Syzygium cumini (L.) Skeels or S. jambos (L.) Alst has been report to be used frequently by diabetic patients. We investigated the postulated antihyperglycemic effect of the S. cumini (L.) Skeels in three experiments. In the first, a randomized, parallel, placebo controlled trial, tea prepared from ...
Tópico(s): Phytochemicals and Antioxidant Activities
2000 - Elsevier BV | Journal of Ethnopharmacology
Danni Zhu, Carlos Castrillón, Michael C. Carroll,
Abstract Systemic lupus erythematosus (SLE) is an incurable autoimmune B cell disorder that is in part due to ineffective clearance of nuclear antigens and activation of the TLR pathway. The extrafollicular (EF) differentiation pathway of antibody secreting cells (ASCs) is recognized to play a prominent role in generating pathogenic antibodies in both mice and human. For example, a novel population of CD21 loCD11c +B cells identified in both mice (age-associated B cells) and human (DN2 cells) are thought ...
Tópico(s): Immune Cell Function and Interaction
2023 - American Association of Immunologists | The Journal of Immunology
Erica Novo, Stefania Cannito, E. Zamara, L. Valfrè di Bonzo, Alessandra Caligiuri, Carlo Cravanzola, Alessandra Compagnone, Sebastiano Colombatto, Fabio Marra, Massimo Pinzani, Maurizio Parola,
... Caligiuri A Robino G Tamagno E Aragno M Danni O Autelli R Colombatto S Dianzani MU Pinzani ... Caligiuri A Robino G Tamagno E Aragno M Danni O Autelli R Colombatto S Dianzani MU Pinzani ... Caligiuri A Robino G Tamagno E Aragno M Danni O Autelli R Colombatto S Dianzani MU Pinzani ... Caligiuri A Robino G Tamagno E Aragno M Danni O Autelli R Colombatto S Dianzani MU Pinzani ... Caligiuri A Robino G Tamagno E Aragno M Danni O Autelli R Colombatto S Dianzani MU Pinzani ... Restivo F Mengozzi G Smedile A Rosina F Danni O Parola M Rizzetto M Neutral endopeptidase (EC ...
Tópico(s): Hepatocellular Carcinoma Treatment and Prognosis
2007 - Elsevier BV | American Journal Of Pathology