Rodrigo Lankaites Pinheiro, Dario Landa-Silva, Jason Atkin,
... for more papers by this authorDario Landa-Silva, Dario Landa-Silva Asap Research Group, School of Computer Science, the ... for more papers by this authorDario Landa-Silva, Dario Landa-Silva Asap Research Group, School of Computer Science, the ...
Tópico(s): Optimization and Mathematical Programming
2017 - Wiley | Journal of Multi-Criteria Decision Analysis
Luís R. Raposo, A. Sanches‐Silva, Dário Silva, Catarina Roma‐Rodrigues, Margarida Espadinha, Pedro V. Baptista, Maria M. M. Santos, Alexandra R. Fernandes,
Cancer is still one of the deadliest diseases worldwide despite the efforts in its early detection and treatment strategies. However, most chemotherapeutic agents still present side effects in normal tissues and acquired resistance that limit their efficacy. Spiropyrazoline oxindoles might be good alternatives as they have shown antiproliferative activity in human breast and colon cancer cell lines, without eliciting cytotoxicity in healthy cells. However, their potential for ovarian cancer was ...
Tópico(s): Synthesis and biological activity
2020 - Elsevier BV | Bioorganic & Medicinal Chemistry
João Ramos, Joana Belo, Dário Silva, Carlos Diogo, Susana Marta Almeida, Nuno Canha,
Sleep is a crucial aspect of the human daily life since it allows us to recover from physical and psychological fatigue and its lack can bring several consequences to human health. People spend around one third of their life sleeping but, despite that, their exposure to pollutants during sleep is often neglected. Specifically, students typically change their habits after entering university, due to the freedom that they are allowed at this stage of their lives. These habits often include their sleep ...
Tópico(s): Urban Green Space and Health
2021 - Elsevier BV | Atmospheric Pollution Research
Ricardo Ferraz, Dário Silva, A.R. Dias, Vitorino Dias, Miguel M. Santos, Luís Pinheiro, Cristina Prudêncio, João Paulo Noronha, Željko Petrovski, Luı́s C. Branco,
The preparation and characterization of ionic liquids and organic salts (OSILs) that contain anionic penicillin G [secoPen] and amoxicillin [seco-Amx] hydrolysate derivatives and their in vitro antibacterial activity against sensitive and resistant Escherichiacoli and Staphylococcusaureus strains is reported. Eleven hydrolyzed β-lactam-OSILs were obtained after precipitation in moderate-to-high yields via the neutralization of the basic ammonia buffer of antibiotics with different cation hydroxide ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2020 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
G. Cottin, Juan Carlos Helo, M. Hirsch, Dario Silva,
We revisit discovery prospects for a long-lived sterile neutrino $N$ at the Large Hadron Collider (LHC) in the context of left-right symmetric theories. We focus on a displaced vertex search strategy sensitive to $\mathcal{O}$(GeV) neutrino masses produced via a right-handed $W_{R}$ boson. Both on-shell and off-shell Drell-Yan production of $W_{R}$ are considered. We estimate the reach as a function of $m_{N}$ and $m_{W_{R}}$. With $\sqrt{s}=13$ TeV and 300/fb of integrated luminosity, the LHC can probe neutrino ...
Tópico(s): High-Energy Particle Collisions Research
2019 - American Physical Society | Physical review. D/Physical review. D.
Produção Nacional
Ricardo Affonso Bernardes, Adriana de Amorim Campelo, Dario Silva S., Luciana Oliveira Pereira, Marco Antônio Húngaro Duarte, Ivaldo Gomes de Moraes, Clóvis Monteiro Bramante,
Objective The aim of this study was to evaluate the flow rate of 3 endodontic sealers: Sealer 26, AH Plus, and MTA Obtura. Study design According to the method proposed by the American Dental Association (ADA specification no. 57), the sealers were placed between 2 glass slabs under a weight of 120 g. The diameters of the formed discs were measured with a digital paquimeter. The test was repeated 5 times for each sealer. Results The results were expressed as arithmetic means, and the statistical ...
Tópico(s): Drilling and Well Engineering
2009 - Elsevier BV | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology
Gabriel L. Cicuttin, María N. De Salvo, Paula Díaz Pérez, Darío Silva, María L. Félix, José M. Venzal, Santiago Nava,
The aim of this work was to report the detection of a putative novel Ehrlichia strain associated with the tick Amblyomma triste. Free-living adult ticks determined as A. triste were collected by drag-sampling in Argentina and Uruguay. Molecular detection of Ehrlichia agents was performed targeting three different loci: 16S rRNA gene, dsb gene and a fragment of groESL heat shock operon. In total, 164 adults of A. triste (38 from INTA E.E.A Delta del Paraná in Argentina and 126 from Toledo Chico in ...
Tópico(s): Insect and Pesticide Research
2020 - Taylor & Francis | Pathogens and Global Health
Joana D. Amaral, Dário Silva, Cecília M. P. Rodrigues, Susana Solá, Maria M. M. Santos,
Brain tumor, as any type of cancer, is assumed to be sustained by a small subpopulation of stem-like cells with distinctive properties that allow them to survive conventional therapies and drive tumor recurrence. Thus, the identification of new molecules capable of controlling stemness properties may be key in developing effective therapeutic strategies for cancer by inducing stem-like cells differentiation. Spiropyrazoline oxindoles have previously been shown to induce apoptosis and cell cycle ...
Tópico(s): Microtubule and mitosis dynamics
2019 - Frontiers Media | Frontiers in Chemistry
Gamze Bölük, Dario Arizala, Jordie R. Ocenar, Julie Mokwele, Joshua Silva, Shefali Dobhal, Jensen Uyeda, Anne M. Alvarez, Mohammad Arif,
... var. japonica) in the United StatesDiksha Klair, Joshua Silva, Dario Arizala, Gamze Boluk, Shefali Dobhal, Amjad A. Ahmad, ... in the United StatesDiksha Klair, Gamze Boluk, Joshua Silva, Dario Arizala, Shefali Dobhal, and Mohammad Arif30 July 2021 | ...
Tópico(s): Plant-Microbe Interactions and Immunity
2020 - American Phytopathological Society | Plant Disease
Produção Nacional
Revisado por pares
Sylvana Melo dos Santos, Jaime Joaquim da Silva Pereira Cabral, Ivaldo Dario da Silva Pontes Filho,
Tópico(s): Geodetic Measurements and Engineering Structures
2012 - Springer Science+Business Media | Natural Hazards
Produção Nacional
Revisado por pares
Jéssica Maria Alexandre Soares, Elenildo Dário da Silva Júnior, Bruno Oliveira de Veras, Ricardo Yara, Priscilla Barbosa Sales de Albuquerque, Marthyna Pessoa de Souza,
Tópico(s): biodegradable polymer synthesis and properties
2021 - Springer Science+Business Media | Journal of Polymers and the Environment
Xiaoping Jiang, Ruibin Bai, Stein W. Wallace, Graham Kendall, Dario Landa-Silva,
Tópico(s): Multi-Criteria Decision Making
2020 - Elsevier BV | Computers & Operations Research
Hoang Lam Le, Dario Landa-Silva, Mikel Galar, Salvador García, Isaac Triguero,
Learning from imbalanced datasets is highly demanded in real-world applications and a challenge for standard classifiers that tend to be biased towards the classes with the majority of the examples. Undersampling approaches reduce the size of the majority class to balance the class distributions. Evolutionary-based approaches are prominent, treating undersampling as a binary optimisation problem that determines which examples are removed. However, their utilisation is limited to small datasets due ...
Tópico(s): Evolutionary Algorithms and Applications
2020 - Elsevier BV | Applied Soft Computing
Juan D. Tibocha‐Bonilla, Manish Kumar, Anne Richelle, Rubén Darío Godoy-Silva, Karsten Zengler, Cristal Zúñiga,
Abstract Cells can sense changes in their extracellular environment and subsequently adapt their biomass composition. Nutrient abundance defines the capability of the cell to produce biomass components. Under nutrient-limited conditions, resource allocation dramatically shifts to carbon-rich molecules. Here, we used dynamic biomass composition data to predict changes in growth and reaction flux distributions using the available genome-scale metabolic models of five eukaryotic organisms (three heterotrophs ...
Tópico(s): Gene Regulatory Network Analysis
2020 - Nature Portfolio | npj Systems Biology and Applications
Alejandra Palomino, Rubén Darío Godoy-Silva, Sofia Raikova, Christopher J. Chuck,
Hydrothermal liquefaction (HTL) is a promising technology that can produce biocrude oil from wet biomass. The biocrudes, while generally acknowledged to be more stable than pyrolysis oils, are still thought to degrade relatively quickly, which limits their applicability. In this investigation, the storage stability of biocrude produced from hydrothermal liquefaction of microalgae was systematically studied over 60 days, and the effect of the storage material, feedstock species, liquefaction temperature ...
Tópico(s): Algal biology and biofuel production
2019 - Elsevier BV | Renewable Energy
Roderick N. Macariola, Dario Landa-Silva,
The construction industry adopts itself to the paradigm shift of today's technology as evident in the numerous researches being conducted to create a more sustainable process and risk-resilient systems in management of projects. In this study, the documentation system of private construction companies in the Philippines served as the primary focus with an intention to scrutinize and improve the data management system of these construction projects. Data was gathered from three(3) different companies ( ...
Tópico(s): Facilities and Workplace Management
2019 - IOP Publishing | IOP Conference Series Materials Science and Engineering
Alejandra Palomino, Luis Carlos Montenegro Ruíz, Rubén Darío Godoy-Silva,
The prediction capacity of published component additivity and kinetic models was analyzed for calculation of the biocrude yield of hydrothermal liquefaction of microalgae. Their advantages and limitations were identified. Likewise, the effect of reaction temperature and retention time was evaluated on the yield of the biocrude for the kinetic models for four hypothetical biomasses. From the analysis of the component additivity and kinetic models, a new quantitative model was proposed for the calculation ...
Tópico(s): Biodiesel Production and Applications
2019 - Elsevier BV | Algal Research
Ruth J Lancheros, Carlos Guerrero, Rubén Darío Godoy-Silva,
N-Acetylcysteine (NAC) is a hydrophilic compound with a low bioavailability. It has been used as an effective antioxidant agent. This research seeks to enhance the entrapment of NAC in PLGA nanoparticles for drug delivery systems. The nanoparticles were made using the nanoprecipitation method and changing the following parameters: the solvent/nonsolvent nature, its viscosity, pH, NAC addition to the nonsolvent, the polymer concentration and molecular weight, and NAC concentration in the solvent. ...
Tópico(s): Advanced Drug Delivery Systems
2018 - Hindawi Publishing Corporation | Journal of Nanotechnology
Tim Curtois, Dario Landa-Silva, Yi Qu, Wasakorn Laesanklang,
An effective and fast hybrid metaheuristic is proposed for solving the pickup and delivery problem with time windows. The proposed approach combines local search, large neighbourhood search and guided ejection search in a novel way to exploit the benefits of each method. The local search component uses a novel neighbourhood operator. A streamlined implementation of large neighbourhood search is used to achieve an effective balance between intensification and diversification. The adaptive ejection ...
Tópico(s): Urban and Freight Transport Logistics
2018 - Springer Science+Business Media | EURO Journal on Transportation and Logistics
Juan D. Tibocha‐Bonilla, Cristal Zúñiga, Rubén Darío Godoy-Silva, Karsten Zengler,
Production of biofuels and bioenergy precursors by phototrophic microorganisms, such as microalgae and cyanobacteria, is a promising alternative to conventional fuels obtained from non-renewable resources. Several species of microalgae have been investigated as potential candidates for the production of biofuels, for the most part due to their exceptional metabolic capability to accumulate large quantities of lipids. Constraint-based modeling, a systems biology approach that accurately predicts ...
Tópico(s): Biofuel production and bioconversion
2018 - Springer Science+Business Media | Biotechnology for Biofuels
Osman Ali Sadek Ibrahim, Dario Landa-Silva,
Learning to rank (LTR) is one of the problems attracting researchers in information retrieval (IR). The LTR problem refers to ranking the retrieved documents for users in search engines, question answering and product recommendation systems. There is a number of LTR approaches based on machine learning and computational intelligence techniques. Most existing LTR methods have limitations, such as being too slow or not being very effective or requiring a huge computer memory to operate. This paper proposes ...
Tópico(s): Text and Document Classification Technologies
2018 - Springer Science+Business Media | Soft Computing
Wasakorn Laesanklang, Dario Landa-Silva,
We tackle home healthcare planning scenarios in the UK using decomposition methods that incorporate mixed integer programming solvers and heuristics. Home healthcare planning is a difficult problem that integrates aspects from scheduling and routing. Solving real-world size instances of these problems still presents a significant challenge to modern exact optimization solvers. Nevertheless, we propose decomposition techniques to harness the power of such solvers while still offering a practical ...
Tópico(s): Scheduling and Optimization Algorithms
2016 - Springer Science+Business Media | Annals of Operations Research
Osman Ali Sadek Ibrahim, Dario Landa-Silva,
In the context of information retrieval (IR) from text documents, the term weighting scheme (TWS) is a key component of the matching mechanism when using the vector space model. In this paper, we propose a new TWS that is based on computing the average term occurrences of terms in documents and it also uses a discriminative approach based on the document centroid vector to remove less significant weights from the documents. We call our approach Term Frequency With Average Term Occurrence (TF-ATO). ...
Tópico(s): Topic Modeling
2015 - Springer Science+Business Media | Soft Computing
Rodrigo Lankaites Pinheiro, Dario Landa-Silva, Jason Atkin,
The workforce scheduling and routing problem (WSRP) is a combinatorial optimisation problem where a set of workers must perform visits to geographically scattered locations. We present a Variable Neighbourhood Search (VNS) metaheuristic algorithm to tackle this problem, incorporating two novel heuristics tailored to the problem-domain. The first heuristic restricts the search space using a priority list of candidate workers and the second heuristic seeks to reduce the violation of specific soft constraints. ...
Tópico(s): Scheduling and Optimization Algorithms
2015 - Springer Nature | Advances in intelligent systems and computing
Jésica de Armas, Eduardo Lalla‐Ruiz, Christopher Expósito‐Izquierdo, Dario Landa-Silva, Belén Melián-Batista,
This paper addresses the Ship Routing and Scheduling Problem with Discretized Time Windows. Being one of the most relevant and challenging problems faced by decision makers from shipping companies, this tramp shipping problem lies in determining the set of contracts that should be served by each ship and the time windows that ships should use to serve each contract, with the aim of minimizing total costs. The use of discretized time windows allows for the consideration of a broad variety of features ...
Tópico(s): Maritime Transport Emissions and Efficiency
2015 - Elsevier BV | Engineering Applications of Artificial Intelligence
J. Arturo Castillo-Salazar, Dario Landa-Silva, Rong Qu,
In the context of workforce scheduling, there are many scenarios in which personnel must carry out tasks at different locations hence requiring some form of transportation. Examples of these type of scenarios include nurses visiting patients at home, technicians carrying out repairs at customers’ locations and security guards performing rounds at different premises, etc. We refer to these scenarios as workforce scheduling and routing problems (WSRP) as they usually involve the scheduling of personnel ...
Tópico(s): Transportation and Mobility Innovations
2014 - Springer Science+Business Media | Annals of Operations Research
Produção Nacional
Revisado por pares
Ademir Aparecido Constantino, Dario Landa-Silva, Everton Luiz de Melo, Candido Ferreira Xavier de Mendonça, Douglas Baroni Rizzato, Wesley Romão,
This paper tackles a Nurse Scheduling Problem which consists of generating work schedules for a set of nurses while considering their shift preferences and other requirements. The objective is to maximize the satisfaction of nurses' preferences and minimize the violation of soft constraints. This paper presents a new deterministic heuristic algorithm, called MAPA (multi-assignment problem-based algorithm), which is based on successive resolutions of the assignment problem. The algorithm has two phases: ...
Tópico(s): Constraint Satisfaction and Optimization
2013 - Springer Science+Business Media | Annals of Operations Research
Mohammad Mesgarpour, Dario Landa-Silva, Ian Dickinson,
Prognostics and Health Management/Monitoring (PHM) are methods to assess the health condition and reliability of systems for the purpose of maximising operational reliability and safety. Recently, PHM systems are emerging in the automotive industry. In the commercial vehicle sector, reducing the maintenance cost and downtime while also improving the reliability of vehicle components can have a major impact on fleet performance and hence business competitiveness. Nowadays, telematics and GPS are used ...
Tópico(s): Transport Systems and Technology
2013 - Springer Science+Business Media | Communications in computer and information science
J.G. Cadavid, Rubén Darío Godoy-Silva, Paulo César Narváez Rincón, Maurício Camargo, C. Fonteix,
Reactive extraction is a potential alternative for biodiesel production, in which reaction and glycerol separation are simultaneous, increasing conversion, yield and process productivity. This paper presents a stepwise reaction–separation model for a counter-current reactive extraction column, used in homogeneous-base-catalyzed palm oil methanolysis, and the models' parameters are identified from the results of a set of experimental tests. In addition, multi-criteria optimisation of the process ...
Tópico(s): Catalysis and Hydrodesulfurization Studies
2013 - Elsevier BV | Chemical Engineering Journal
Produção Nacional
Revisado por pares
Carlos Dario da Silva Costa, Sandro Scarpelini,
OBJETIVO: Caracterizar os óbitos decorrentes de trauma em um hospital terciário e avaliar a qualidade do atendimento prestado a essas vítimas. MÉTODOS: Tratou-se de um estudo retrospectivo realizado em um centro de referência em trauma no período de um ano. Através da metodologia Trauma Score - Injury Severity Score e da revisão de prontuários foram identificadas e estudadas as mortes evitáveis, potencialmente evitáveis e inevitáveis. RESULTADOS: Setenta e cinco pacientes foram incluídos no estudo. ...
Tópico(s): Emergency and Acute Care Studies
2012 - Brazilian College of Surgeons | Revista do Colégio Brasileiro de Cirurgiões