Robert Nowicki, Robert Seliga, Dariusz Żelasko, Yoichi Hayashi,
Abstract The paper presents a performance analysis of a selected few rough set–based classification systems. They are hybrid solutions designed to process information with missing values. Rough set-–based classification systems combine various classification methods, such as support vector machines, k–nearest neighbour, fuzzy systems, and neural networks with the rough set theory. When all input values take the form of real numbers, and they are available, the structure of the classifier returns ...
Tópico(s): Imbalanced Data Classification Techniques
2021 - Polish Neural Network Society, the University of Social Sciences in Lodz & Czestochowa University of Technology | Journal of Artificial Intelligence and Soft Computing Research
Magdalena Kaczor, Milena Greczan, Karolina Kierus, Ewa Ehmke vel Emczyńska‐Seliga, Elżbieta Ciara, Barbara Piątosa, Dariusz Rokicki, Janusz Książyk, Dorota Wesół‐Kucharska,
Glycogen storage disease type 1b (GSD 1b) is an inherited metabolic defect caused by biallelic mutations in the
Tópico(s): Oral and gingival health research
2022 - Wiley | JIMD Reports
Dorota Wesół‐Kucharska, Magdalena Kaczor, Magdalena Pajdowska, Ewa Ehmke vel Emczyńska‐Seliga, Anna Bogdańska, Dariusz Kozłowski, Dorota Piekutowska‐Abramczuk, Elżbieta Ciara, Dariusz Rokicki,
Methylmalonic Aciduria (MMA) is a heterogeneous group of rare diseases leading to accumulation of methylmalonic acid in body fluids. One of the causes of the disease is the methylmalonic aciduria, cblA type (cblA - type MMA), conditioned by a mutation in the MMAA gene, which is essential for the proper functioning of a cofactor of the methylmalonyl-CoA mutase. The symptoms of the disease, depending on the cause, may manifest themselves at different ages. Most patients are sensitive to high doses of ...
Tópico(s): Neonatal Health and Biochemistry
2020 - Elsevier BV | Molecular Genetics and Metabolism Reports
Edyta Szymańska, Aleksandra Jezela‐Stanek, Anna Bogdańska, Dariusz Rokicki, Ewa Ehmke vel Emczyńska‐Seliga, Magdalena Pajdowska, Elżbieta Ciara, Anna Tylki‐Szymańska,
Isovaleric acidemia (IVA) is an autosomal recessive leucine inborn error of metabolism caused by isovaleryl-CoA dehydrogenase deficiency. The disease has various courses, from severe ones manifesting in newborns to the intermittent form with first manifestation in children and adults. The aim of this study was to analyze clinical and neurological outcomes in Polish patients with IVA. Ten patients diagnosed and treated in The Children's Memorial Health Institute were included in the study. The diagnosis ...
Tópico(s): Folate and B Vitamins Research
2020 - Multidisciplinary Digital Publishing Institute | Diagnostics
Edyta Szymańska, Ewa Ehmke vel Emczyńska‐Seliga, Dariusz Rokicki, Janusz Książyk,
Summary Background Patients with hepatic glycogen storage diseases (GSDs) are prone to accumulation of an excessive body fat due to dietary therapy with frequent meals and addition of uncooked cornstarch. The aim of this study was to estimate body composition, in particular body fat in Polish pediatric patients with GSDs using BIA. Patients and methods Twenty four patients with hepatic GSDs: I, III/VI/IX,0: 9,14,1, respectively, aged 8.5 years (SD = 2.8) were included into the study. The average fasting time ...
Tópico(s): Metabolism and Genetic Disorders
2017 - Elsevier BV | Clinical Nutrition ESPEN
Magdalena Kaczor, Dorota Wesół‐Kucharska, Milena Greczan, Karolina Kierus, Łukasz Kałużny, Monika Duś-Żuchowska, Ewa Ehmke vel Emczyńska‐Seliga, Elżbieta Ciara, Janusz Książyk, Dariusz Rokicki,
Glycogen storage disease type 1b (GSD 1b) is an inherited metabolic defect caused by a deficiency of microsomal glucose-6-phosphate (G6P) transport protein across the endoplasmic reticulum membrane. Patients with GSD 1b have hypoglycemia episodes, lactate acidosis, hypertriglyceridemia, hypercholesterolemia, hyperuricemia, neutropenia and in imaging studies hepatomegaly and/or nephromegaly. The primary goals of treatment are to maintain proper blood glucose levels and to increase the number of properly ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2022 - | Pediatric Endocrinology Diabetes and Metabolism
Andrzej Frankowski, Dariusz Deredas, Estelle Dubost, F. Gessier, Stefan Jankowski, Markus Neuburger, C. SELIGA, Théophile Tschamber, Kamil Weinberg,
The syntheses of imidazolo[1,5]hexopiperidinoses 2–6 and imidazol-4(5)-yl C-glycosides 7–9 are reported. The crucial step of this approach relies upon the SN2-type cyclisation of selectively protected C(1), C(2), C(3) and C(5)-substituted 1-[imidazol-4(5)-yl]pentitols in which the imidazole nitrogen or the C(1)-connected oxygen are involved as the competitive nucleophilic centers, respectively. Six selected imidazolosugars were evaluated as potential inhibitors of glycosidases.
Tópico(s): Synthesis of Indole Derivatives
2003 - Elsevier BV | Tetrahedron
Dariusz Madajczak, Joanna Seliga‐Siwecka, Maria Katarzyna Borszewska-Kornacka,
Tópico(s): Neuroscience of respiration and sleep
2008 - Elsevier BV | Early Human Development
Dorota Wesół‐Kucharska, Milena Greczan, Magdalena Kaczor, Ewa Ehmke vel Emczyńska‐Seliga, Małgorzata Hajdacka, Edyta Czekuć-Kryśkiewicz, Dorota Piekutowska‐Abramczuk, Paulina Halat-Wolska, Elżbieta Ciara, Maciej Jaworski, Aleksandra Jezela‐Stanek, Dariusz Rokicki,
Mitochondrial diseases (MDs) are a heterogeneous group of disorders resulting from abnormal mitochondrial function. Currently, there is no causal treatment for MDs. The aim of the study was to assess the effectiveness and safety of the ketogenic diet (KD) in patients with MD and to analyse selected biochemical and clinical parameters evaluating the effectiveness of KD treatment in patients with MDs. A total of 42 paediatric patients were assigned to four groups: group 1—patients with MD in whom KD ...
Tópico(s): Mitochondrial Function and Pathology
2024 - Multidisciplinary Digital Publishing Institute | Nutrients
Andrzej Frankowski, Dariusz Deredas, Estelle Dubost, F. Gessier, Stefan Jankowski, Markus Neuburger, C. SELIGA, Théophile Tschamber, Kamil Weinberg,
Abstract For Abstract see ChemInform Abstract in Full Text.
Tópico(s): Enzyme Catalysis and Immobilization
2003 - Wiley | ChemInform
Małgorzata Batycka, Ewa Lange, Ewa Ehmke vel Emczyńska‐Seliga, Maciej Jaworski, Maria Kóbylińska, Natalia Lech, Emilia Samborowska, Patryk Lipiński, Barbara Perkowska, Paulina Pokora, Dariusz Rokicki,
Background: Classical homocystinuria (HCU) is an inborn defect of methionine metabolism caused by a deficiency of the enzyme cystathionine β-synthase (CBS). The main symptoms of classical homocystinuria are lens subluxation, bone lesions, vascular disease and developmental delay/intellectual disability. The treatment method for HCU is a methionine-poor diet supplemented with amino acid preparations. The aim of the study was to examine the relationship of dietary factors, metabolic compensation and ...
Tópico(s): Bone health and osteoporosis research
2023 - Multidisciplinary Digital Publishing Institute | Nutrients