"E. LYTTELTON.", W. H. QUARRELL. 3, East India-avenue, E.C.3, Nov. 12., November 12. COMYNS BERKELEY., G. MAJOR., ELIZABETH MACADAM., MATTHEW NATHAN.,
... Loss Of The Mendi: Limitation Of Liability. The Darro.. News in Brief. News: Munition Women's Wages. ...
1917 - Gale Group | TDA
Gabriela E. Davey, Petra Murmann, Claus W. Heizmann,
... 9) Google Scholar, 37De Hauwer C. Camby I. Darro F. Decaestecker C. Gras T. Salmon I. Kiss ... 32) Google Scholar, 38De Hauwer C. Camby I. Darro F. Migeotte I. Decaestecker C. Verbeek C. Danguy ... 9) Google Scholar, 37De Hauwer C. Camby I. Darro F. Decaestecker C. Gras T. Salmon I. Kiss ... 32) Google Scholar, 38De Hauwer C. Camby I. Darro F. Migeotte I. Decaestecker C. Verbeek C. Danguy ...
Tópico(s): Antimicrobial Peptides and Activities
2001 - Elsevier BV | Journal of Biological Chemistry
A. BERRIEDALE KEITH., J. G. BUTCHER., JOHN C. VAN DER VEER, London, August 8. EX-R.A.M.C., A WOMAN., T. VANSITTART BOWATER. 159, Queen Victoria-street, E.C., Aug. 7., E. T. L., THOS. GIBSON BOWLES., GRANVILLE FARQUHAR., F. W. RAWLINSON, Secretary, Royal Merchant Seamen's Orphanage, Snaresbrook., Westminster, Aug. 8. C., From Our Parliamentary Correspondent., August 7. A MOTHER., August 8. WORKER FOR A LOCAL W.P.C.,
... Of The Mendi. Certificate Of Master Of The Darro Suspended., London Boundary Inquiries. Objections To The Finsbury ...
1917 - Gale Group | TDA
Eloísa Manzano, Ana García Bueno, Antonio González‐Casado, Monsalud del Olmo‐Iruela,
The Carrera del Darro is a street within the city of Granada, Spain, which is emblematic owing to the architectural value of its ... 25, 27 and 29 of the Carrera del Darro. From the analysis of the mortar, it may ...
Tópico(s): Conservation Techniques and Studies
2000 - Elsevier BV | Journal of Cultural Heritage
Gaik W. Tew, Ellen Lorimer, Tracy J. Berg, Huiying Zhi, Rongshan Li, Carol L. Williams,
... De Beeck A. Van Quaquebeke E. Dewelle J. Darro F. de Launoit Y. Kiss R. Mol. Cancer ... De Beeck A. Van Quaquebeke E. Dewelle J. Darro F. de Launoit Y. Kiss R. Mol. Cancer ...
Tópico(s): Bone Metabolism and Diseases
2007 - Elsevier BV | Journal of Biological Chemistry
... y se encuentra en los rios Genil y Darro, donde se ha bateado desde la epoca romana ... tramos en los que los rios Genil y Darro atraviesan el Conglomerado Alhambra
Tópico(s): Archaeological and Geological Studies
2000 - Spanish National Research Council | BOLETÍN GEOLÓGICO Y MINERO
Paz Fernández Oliveras, Expectación Delgado, Mónica López-Alonso, J. M. Poyatos,
... analyses of soil and environmental information for the Darro River basin (Granada-Spain) preliminary to its hydrological ...
Tópico(s): Hydrology and Watershed Management Studies
2017 - Elsevier BV | The Science of The Total Environment
Alberto López Mullor, Javier Fierro Maciá,
-
Tópico(s): Archaeological and Geological Studies
1990 - National University of Distance Education | Espacio Tiempo y Forma Serie I Prehistoria y Arqueología
Olivier Blanchard, Stanley Fischer,
... 10.2139/ssrn.2123632Alberto Jaramillo, Hugo Obando, Ivvn Darro Arroyave La Polltica Coyuntural De La Empresa (Firm ...
Tópico(s): Financial Literacy, Pension, Retirement Analysis
1989 - University of Chicago Press | NBER Macroeconomics Annual
Alberto López Mullor, Javier Fierro Maciá,
El yacimiento está situado en el casco urbano de Vilanova i la Geltrú, concretamente en la zona donde confluyen el actual paseo marítimo de Ribes Roges y la elevación denominada Turó de Sant Gervasi (fig. 1,b). El sitio comprende un asentamiento ibérico y una villa romana. Las ruinas se conocen desde antiguo, y fueron objeto de una primera excavación en 1955 y 1956 por parte del profesor Antonio Arribas (Arribas 1956: 23-48; Id. 1958: 323-329). Desde entonces, los trabajos se paralizaron hasta 1977, ...
Tópico(s): Archaeological and Geological Studies
1988 - National University of Distance Education | Espacio Tiempo y Forma Serie II Historia Antigua
The northeast Brazilian rift basins provide important data critical to the understanding of continental rifting processes associated with the opening of the South Atlantic. These basins represent the locus of intersection of the Southern and Equatorial branches and some basins yield substantial chronostratigraphic data that constrain the temporal and spatial interaction of the rift phases. Similar data are not found in its counterpart in Africa, especially for the Neocomian. These Early Cretaceous ...
Tópico(s): earthquake and tectonic studies
1992 - Wiley | Tectonics
Renato M. Darros de Matos, L. D. Brown,
Deep seismic profiling of the Amazonian craton (northern Brazil) reveals previously unknown deep structural features buried beneath a thin, relatively flat Phanerozoic sedimentary cover (Amazon basin). The seismic signature of the Precambrian crust is characterized by a transparent shallow basement down to 8–9 km followed by a highly reflective middle and lower crust. Middle and lower crustal events are dominated by abundant dipping, asymmetric arcuate reflections and diffractions, the shallowest ...
Tópico(s): earthquake and tectonic studies
1992 - Wiley | Tectonics
Benoı̂t Joseph, Francis Darro, Aurélie Béhard, Brigitte Lesur, Françoise Collignon, Christine Decaestecker, Armand Frydman, Gérald Guillaumet, Róbert Kiss,
Among 25 3-aryl-2-quinolone derivatives synthesized, the antitumor activity of some of them was characterized both in vitro and in vivo. In this series, no compound appeared to be cytotoxic in vitro, as was known by the colorimetric MTT assay carried out on 12 distinct human cancer cell lines obtained from the American Type Culture Collection. Indeed, the concentration values decreasing the growth of the 12 cell lines by at least 50% (IC50 index) were always higher than 10-5 M. We then made use of ...
Tópico(s): Synthesis and Biological Evaluation
2002 - American Chemical Society | Journal of Medicinal Chemistry
Evelyne Delfourne, Francis Darro, Philippe Portefaix, Chantal Galaup, Sylvie Bayssade, Anne Pujol Bouteille, Laurent Le Corre, Jean Bastide, Françoise Collignon, Brigitte Lesur, Armand Frydman, Róbert Kiss,
Marine compounds with pyridoacridine skeletons are known to exhibit interesting antitumor activities. Ascididemin has already been reported as displaying significant antitumor activities in vitro and has also been found to have a relatively high global toxicity in vivo. We synthesized a series of 16 analogues (among which 11 compounds were different from previously described ones) with the aim of developing new anticancer agents with significantly improved efficacy/tolerability ratios. These compounds ...
Tópico(s): Synthesis and Catalytic Reactions
2002 - American Chemical Society | Journal of Medicinal Chemistry
Isabelle Camby, Nathalie Belot, Florence Lefranc, Niloufar Sadeghi, Yvan de Launoit, Herbert Kaltner, Sophie Musette, Francis Darro, André Danguy, Isabelle Salmon, Hans‐Joachim Gabius, Róbert Kiss,
We show that high-grade astrocytic tumors with high levels of galectin-1 expression are associated with dismal prognoses. The immunohistochemical analysis of galectin-1 expression of human U87 and U373 glioblastoma xenografts from the brains of nude mice revealed a higher level of galectin-1 expression in invasive areas rather than non-invasive areas of the xenografts. Nude mice intracranially grafted with U87 or U373 cells constitutively expressing low levels of galectin-1 (by stable transfection ...
Tópico(s): Glycosylation and Glycoproteins Research
2002 - Oxford University Press | Journal of Neuropathology & Experimental Neurology
Caroline Hayot, Sophie Farinelle, Robert De Decker, Christine Decaestecker, Francis Darro, Róbert Kiss, Marc Van Damme,
The aim of the present work is to investigate whether microtubule-affecting drugs including vincristine, vinblastine, vindesine and vinorelbine are able to produce an anti-angiogenic effect at non-cytotoxic doses in the same way of taxol. The cytotoxic effects were determined by means of the colorimetric MTT assay, and the anti-angiogenic effects on HUVEC cells growing on Matrigel and forming capillary networks. Sixteen additional drugs (camptothecin, SN38, topothecan, adriamycin, daunomycin, etoposide, ...
Tópico(s): 3D Printing in Biomedical Research
2002 - Spandidos Publishing | International Journal of Oncology
Christine Brahic, Francis Darro, Mirabelle Belloir, Jean Bastide, Róbert Kiss, Evelyne Delfourne,
4-Substituted-7H-pyrido-[4,3,2-de][1,8] or [1,9]-phenanthroline-7-ones and 9-methyl-1,4-diazanaphtacene-3,10-dione, analogues of the marine pyridoacridine amphimedine were synthesised from isoquinoline-5,8-dione. The first compounds were obtained starting from a Diels-Alder reaction whereas the synthesis of the last compound was initiated by a reaction of condensation with 2-aminoacetophenone. The different tetra- and pentacyclic compounds were evaluated for in vitro cytotoxic activities against ...
Tópico(s): Synthesis and Biological Activity
2002 - Elsevier BV | Bioorganic & Medicinal Chemistry
Róger Darros Barbosa, Murat Ö. Balaban, Arthur A. Teixeira,
Abstract Density of binary solutions and combinations of sucrose, glucose, fructose, citric acid, malic acid, pectin, and inorganic salts were measured with an oscillating tube density meter in the temperature range from 10° to 60°C, at varying concentrations. Density can be predicted with accuracy better than 5 × 10−5 g cm−3 using predictive equations obtained by fitting the experimental data. Available literature values agreed well with experimental data. Relations for the excess molar volume of ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2003 - Marcel Dekker | International Journal of Food Properties
Claude Agami, François Couty, Gwilherm Evano, Francis Darro, Róbert Kiss,
Abstract Six analogues (labeled 27 to 32 ) of a cytotoxic alkaloid isolated from the tunicate Clavelina picta were synthesized from an acyl oxazolidine. The absolute stereochemistry of the targeted analogues derived from ( R )‐phenyl glycinol and the relative stereochemistries of three of the four stereocentres present in the molecule were set up by stereocontrolled additions to transient iminium ions. The main features of this synthesis include (i) a high level of stereocontrol for all the steps involving ...
Tópico(s): Asymmetric Synthesis and Catalysis
2003 - Wiley | European Journal of Organic Chemistry
Evelyne Delfourne, Róbert Kiss, Laurent Le Corre, Frédéric Dujols, Jean Bastide, Françoise Collignon, Brigitte Lesur, Armand Frydman, Francis Darro,
A series of substituted pyrido[4,3,2-de][1,7] or [1,10]-phenanthrolin-7-ones, analogues of the marine pyridoacridines meridine and ascididemin, have been synthesized on the basis of Diels-Alder reactions involving different quinoline-5,8-diones and N,N-aldehyde-dimethylhydrazones. All the compounds were evaluated for in vitro cytotoxic activity against 12 distinct human cancer cell lines. They all exhibit cytotoxic activity with IC(50) values at least of micromolar order.
Tópico(s): Marine Sponges and Natural Products
2003 - American Chemical Society | Journal of Medicinal Chemistry
Róger Darros Barbosa, Murat Ö. Balaban, Arthur A. Teixeira,
Heat capacities of binary aqueous solutions of different concentrations of sucrose, glucose, fructose, citric acid, malic acid, and inorganic salts were measured with a differential scanning calorimeter in the temperature range from 5°C to 65°C. Heat capacity increased with increasing water content and increasing temperature. At low concentrations, heat capacity approached that of pure water, with a less pronounced effect of temperature, and similar abnormal behavior of pure water with a minimum ...
Tópico(s): Advanced Thermodynamics and Statistical Mechanics
2003 - Marcel Dekker | International Journal of Food Properties
Evelyne Delfourne, Róbert Kiss, Laurent Le Corre, Joumaa Merza, Jean Bastide, Armand Frydman, Francis Darro,
The isomer (9H-quino[4,3,2-de][1,7]phenanthroline-9-one) (2) of the marine alkaloid ascididemin (9H-quino[4,3,2-de][1,10]phenanthroline-9-one) (1) has been synthesized in six steps from 1,4-dimethoxyacridine (10) with an overall yield of 12%. Different related compounds were prepared and tested in vitro at six different concentrations on 12 different human cancer cell lines of various histopathological types (glioblastomas and breast, colon, lung, prostate and bladder cancers). Almost all the compounds ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2003 - Elsevier BV | Bioorganic & Medicinal Chemistry
Bruno Delest, Prosper Nshimyumukiza, Olivier Fasbender, Bernard Tinant, Jacqueline Marchand‐Brynaert, Francis Darro, Raphaël Robiette,
A divergent and regioselective synthesis of 1,2,4- and 1,2,5-trisubstituted imidazoles from a readily available (two steps) common intermediate has been developed. This methodology is based on the regiocontrolled N-alkylation of 1-(N,N-dimethylsulfamoyl)-5-iodo-2-phenylthio-1H-imidazole (10). When this intermediate is engaged in reaction with methyl triflate, selective formation of the corresponding 1,2,5-trisubsituted 1H-imidazole is observed. NMR studies have revealed that this regioselectivity ...
Tópico(s): Multicomponent Synthesis of Heterocycles
2008 - American Chemical Society | The Journal of Organic Chemistry
Tatjana Mijatovic, Tina Mahieu, Céline Bruyère, Nancy De Nève, Janique Dewelle, Gentiane Simon, Mischaël Dehoux, Ellen van der Aar, Benjamin Haibe‐Kains, Gianluca Bontempi, Christine Decaestecker, Eric Van Quaquebeke, Francis Darro, Róbert Kiss,
Several naphthalimides have been evaluated clinically as potential anticancer agents. UNBS3157, a naphthalimide that belongs to the same class as amonafide, was designed to avoid the specific activating metabolism that induces amonafide's hematotoxicity. The current study shows that UNBS3157 rapidly and irreversibly hydrolyzes to UNBS5162 without generating amonafide. In vivo UNBS5162 after repeat administration significantly increased survival in orthotopic human prostate cancer models. Results ...
Tópico(s): Multiple Myeloma Research and Treatments
2008 - Elsevier BV | Neoplasia
Laurent Ingrassia, Florence Lefranc, Véronique Mathieu, Francis Darro, Róbert Kiss,
This review covers the isolation, total synthesis, biologic activity, and more particularly the in vitro and in vivo antitumor activities of naturally occurring isocarbostyril alkaloids from the Amaryllidaceae family. Starting from these natural products, new derivatives have been synthesized to explore structure-activity relationships within the chemical class and to obtain potential candidates for preclinical development. This approach appears to be capable of providing novel promising anticancer ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2008 - Elsevier BV | Translational Oncology
Bryan P. Murray, Brian K. Horton, Renato M. Darros de Matos, M. T. Heizler,
Research Article| September 01, 2010 Oligocene–Miocene basin evolution in the northern Altiplano, Bolivia: Implications for evolution of the central Andean backthrust belt and high plateau Bryan P. Murray; Bryan P. Murray † 1Department of Earth Science, University of California, Santa Barbara, Webb Hall, Santa Barbara, California 93106-9630, USA †E-mail: bmurray@umail.ucsb.edu Search for other works by this author on: GSW Google Scholar Brian K. Horton; Brian K. Horton 2Institute for Geophysics and ...
Tópico(s): Geochemistry and Geologic Mapping
2010 - Geological Society of America | Geological Society of America Bulletin
Tatjana Mijatovic, Eric Van Quaquebeke, Bruno Delest, Olivier Debeir, Francis Darro, Róbert Kiss,
The sodium pump, Na(+)/K(+)-ATPase, could be an important target for the development of anti-cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion and its aberrant expression and activity are implicated in the development and progression of different cancers. Cardiotonic steroids, known ligands of the sodium pump have been widely used for the treatment of heart failure. However, early epidemiological evaluations and subsequent demonstration of anti-cancer ...
Tópico(s): Heart Failure Treatment and Management
2007 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Franklin C. Harwood, Lili Shu, Peter J. Houghton,
... mitogenic in sarcoma cells (37Remmelink M. Decaestecker C. Darro F. Goldschmidt D. Gebhart M. Pasteels J.L. ...
Tópico(s): Polyamine Metabolism and Applications
2007 - Elsevier BV | Journal of Biological Chemistry
Patrick Dumont, Laurent Ingrassia, Sébastien Rouzeau, Fabrice Ribaucour, Stéphanie Thomas, Isabelle Roland, Francis Darro, Florence Lefranc, Róbert Kiss,
Our study has shown that the Amaryllidaceae isocarbostyril narciclasine induces marked apoptosismediated cytotoxic effects in human cancer cells but not in normal fibroblasts by triggering the activation of the initiator caspases of the death receptor pathway (caspase-8 and caspase-10) at least in human MCF-7 breast and PC-3 prostate carcinoma cells. The formation of the Fas and death receptor 4 (DR4) death-inducing signaling complex was clearly evidenced in MCF-7 and PC-3 cancer cells. Caspase-8 ...
Tópico(s): Marine Toxins and Detection Methods
2007 - Elsevier BV | Neoplasia
Mostafa Salmoun, J. C. Braekman, Y. Ranarivelo, Richard Rasamoelisendra, Dimby Andrianina RALAMBOMANANA, Janique Dewelle, Francis Darro, Róbert Kiss,
Four calamenene sequiterpenes, (+)-(7R,10S)-15-hydroxycalamenene (3), (+)-(7R,10S)-2,15-dihydroxycalamenene (4), (+)-(7R,10S)-2-hydroxy-15-calamenal (5), (+)-(7R,10S)-15-calamenal (6), along with the amorphane sesquiterpene (+)-(1S,6R,7R,10S)-1-hydroxy-3-oxo-amorph-4-ene (16), have been isolated from the Madagascan shrub Tarenna madagascariensis (Rubiaceae) and their structures determined by spectroscopic methods and chemical correlations. Furthermore, five known related sesquiterpenes [(+)-(7R,10S)-2-hydroxycalamenene (1), (+)-(7R,10S)- ...
Tópico(s): Phytochemical compounds biological activities
2007 - Taylor & Francis | Natural Product Research