Boris Cheval, Liza Darrous, Karmel W. Choi, Yann C. Klimentidis, David A. Raichlen, Gene E. Alexander, Stéphane Cullati, Zoltán Kutalik, Matthieu P. Boisgontier,
Abstract Physical activity and cognitive functioning are strongly intertwined. However, the causal relationships underlying this association are still unclear. Physical activity can enhance brain functions, but healthy cognition may also promote engagement in physical activity. Here, we assessed the bidirectional relationships between physical activity and general cognitive functioning using Latent Heritable Confounder Mendelian Randomization (LHC-MR). Association data were drawn from two large-scale ...
Tópico(s): Obesity, Physical Activity, Diet
2023 - Nature Portfolio | Scientific Reports
Jonathan Sulc, Anthony Sonrel, Ninon Mounier, Chiara Auwerx, Eirini Marouli, Liza Darrous, Bogdan Draganski, Tuomas O. Kilpeläinen, Peter K. Joshi, Ruth J. F. Loos, Zoltán Kutalik,
Abstract Obesity is a major risk factor for a wide range of cardiometabolic diseases, however the impact of specific aspects of body morphology remains poorly understood. We combined the GWAS summary statistics of fourteen anthropometric traits from UK Biobank through principal component analysis to reveal four major independent axes: body size, adiposity, predisposition to abdominal fat deposition, and lean mass. Mendelian randomization analysis showed that although body size and adiposity both ...
Tópico(s): Obesity, Physical Activity, Diet
2021 - Nature Portfolio | Communications Biology
Liza Darrous, Ninon Mounier, Zoltán Kutalik,
Abstract Mendelian Randomisation (MR) is an increasingly popular approach that estimates the causal effect of risk factors on complex human traits. While it has seen several extensions that relax its basic assumptions, most suffer from two major limitations; their under-exploitation of genome-wide markers, and sensitivity to the presence of a heritable confounder of the exposure-outcome relationship. To overcome these limitations, we propose a Latent Heritable Confounder MR (LHC-MR) method applicable ...
Tópico(s): Folate and B Vitamins Research
2021 - Nature Portfolio | Nature Communications
Eleonora Porcu, Federica Gilardi, Liza Darrous, Loïc Yengo, Nasim Bararpour, Marie Gasser, Pedro Marquès-Vidal, Philippe Froguel, Gérard Waeber, Aurélien Thomas, Zoltán Kutalik,
Abstract The number of people affected by Type 2 diabetes mellitus (T2DM) is close to half a billion and is on a sharp rise, representing a major and growing public health burden. Given its mild initial symptoms, T2DM is often diagnosed several years after its onset, leaving half of diabetic individuals undiagnosed. While several classical clinical and genetic biomarkers have been identified, improving early diagnosis by exploring other kinds of omics data remains crucial. In this study, we have ...
Tópico(s): Genetic Associations and Epidemiology
2021 - Nature Portfolio | Scientific Reports
Eleonora Porcu, Jennifer Sjaarda, Kaido Lepik, Cristian Carmeli, Liza Darrous, Jonathan Sulc, Ninon Mounier, Zoltán Kutalik,
Eleonora Porcu1,2,3,6, Jennifer Sjaarda2,3,6, Kaido Lepik3,4, Cristian Carmeli3, Liza Darrous2,3, Jonathan Sulc2,3, Ninon Mounier2,3 and Zoltán Kutalik2,3,5 1Center for Integrative Genomics, University of Lausanne, Lausanne 1015, Switzerland 2Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland 3University Center for Primary Care and Public Health, University of Lausanne, Lausanne 1010, Switzerland 4Institute of Computer Science, University of Tartu, Tartu 50409, Estonia 5Genetics of Complex ...
Tópico(s): Genetic Associations and Epidemiology
2020 - Cold Spring Harbor Laboratory Press | Cold Spring Harbor Perspectives in Medicine
... work, carried out in 1993-1994 by N. Darrous ; an archaeological and historical synthesis combined with field ...
Tópico(s): Classical Antiquity Studies
2004 - Institut français du Proche-Orient | Syria
Liza Darrous, Gibran Hemani, George Davey Smith, Zoltán Kutalik,
Mendelian Randomisation (MR) estimates causal effects between risk factors and complex outcomes using genetic instruments. Pleiotropy, heritable confounders, and heterogeneous causal effects violate MR assumptions and can lead to biases. To alleviate these, we propose an approach employing a Phenome-Wide association Clustering of the MR instruments (PWC-MR) and apply this method to revisit the surprisingly large apparent causal effect of body mass index (BMI) on educational attainment (EDU): [Formula: ...
Tópico(s): Bioinformatics and Genomic Networks
2024 - Nature Portfolio | Nature Communications
Sven E. Ojavee, Liza Darrous, Marion Patxot, Kristi Läll, Krista Fischer, Reedik Mägi, Zoltán Kutalik, Matthew R. Robinson,
There is currently little evidence that the genetic basis of human phenotype varies significantly across the lifespan. However, time-to-event phenotypes are understudied and can be thought of as reflecting an underlying hazard, which is unlikely to be constant through life when values take a broad range. Here, we find that 74% of 245 genome-wide significant genetic associations with age at natural menopause (ANM) in the UK Biobank show a form of age-specific effect. Nineteen of these replicated discoveries ...
Tópico(s): Genetic factors in colorectal cancer
2023 - Elsevier BV | The American Journal of Human Genetics
Boris Cheval, Liza Darrous, Karmel W. Choi, Yann C. Klimentidis, David A. Raichlen, Gene E. Alexander, Stéphane Cullati, Zoltán Kutalik, Matthieu Boisgontier,
Physical activity and cognitive functioning are strongly intertwined. However, the causal relationships underlying this association are still unclear. Physical activity can enhance brain functions, but healthy cognition may also promote engagement in physical activity. Here, we assessed the bidirectional relationships between physical activity and general cognitive functioning using Latent Heritable Confounder Mendelian Randomization (LHC-MR). Association data were drawn from two large-scale genome- ...
Tópico(s): Nutrition, Genetics, and Disease
2022 - RELX Group (Netherlands) | SSRN Electronic Journal