Lourdes Ortiz‐Fernández, F. David Carmona, Marco-Antonio Montes-Cano, José-Raúl Garcı́a-Lozano, Marta Conde‐Jaldón, Norberto Ortego‐Centeno, María J. Castillo, Gerard Espinosa, Jenaro Graña Gil, Juan Sánchez‐Bursón, María Rosa Juliá, Roser Solans, Ricardo Blanco, Ana-Celia Barnosi-Marín, Ricardo Gómez de la Torre, P. Fanlo, Mónica Rodríguez‐Carballeira, Luis Rodríguez‐Rodríguez, Teresa Camps, Santos Castañeda, Juan José Alegre Sancho, Javier Martı́n, María Francisca González‐Escribano,
Behcet's disease (BD) is an immuno-mediated vasculitis in which knowledge of its etiology and genetic basis is limited. To improve the current knowledge, a genetic analysis performed with the Immunochip platform was carried out in a population from Spain. A discovery cohort comprising 278 BD cases and 1,517 unaffected controls were genotyped using the Immunochip platform. The validation step was performed on an independent replication cohort composed of 130 BD cases and 600 additional controls. The ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2016 - Public Library of Science | PLoS ONE
Lourdes Ortiz‐Fernández, F. David Carmona, Raquel López-Mejías, María Francisca González‐Escribano, Paul Lyons, Ann W. Morgan, Amr H. Sawalha, Peter A. Merkel, Kenneth G. C. Smith, Miguel Á. González‐Gay, Javier Martı́n,
Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we performed the first cross-phenotype meta-analysis of genetic data from different clinically distinct patterns of vasculitis.
Tópico(s): Mast cells and histamine
2018 - BMJ | Annals of the Rheumatic Diseases
Pablo Campo, Fernando Maestú, Almudena Capilla, Manuel Morales Ortíz, Santiago Fernández, David del Río, Tomás Ortiz,
Most of human cognitive activity involves, to a greater or lesser extent, the integration of information from different modalities, a process also referred to as 'binding'. Although the neural basis of several forms of binding has been extensively investigated, the neurobiological mechanisms of the encoding phase of integration of words and their spatial location have not been previously investigated. This process is at the core of what Baddeley proposed in his revised model as episodic buffer. In ...
Tópico(s): Visual and Cognitive Learning Processes
2008 - American Psychological Association | Neuropsychology
David Gómez-Ortíz, David C. Fernández‐Remolar, Ángel Granda, Cecilio Quesada, Teresa Granda, O. Prieto‐Ballesteros, A. Molina, Ricardo Amils,
The acidic waters of the Río Tinto rise from several acidic springs that emerge in the area surrounding Peña de Hierro (Fernández-Remolar et al., 2005). These springs are located above minor normal faults that act as natural conduits for the water from the underlying deep aquifer. Although it has been suggested that the acidity of the river originates from the biooxidation of massive and stockwork sulfides (Fernández-Remolar et al., 2008a), the location of the source for these acidic solutions has ...
Tópico(s): Geophysical and Geoelectrical Methods
2014 - Elsevier BV | Earth and Planetary Science Letters
David C. Fernández‐Remolar, O. Prieto‐Ballesteros, David Gómez-Ortíz, M. Fernández-Sampedro, P. C. Sarrazin, M. Gailhanou, Ricardo Amils,
The presence of extensive phyllosilicate deposits from the early Noachian of Mars are often interpreted as having formed from neutral to subalkaline solutions. In this paper we examine the Río Tinto fluvial basin, an early Mars analog, that hosts clay production and sedimentation along the entire course of the river. At Río Tinto, phyllosilicate minerals including clays and micas are sourced by volcanosedimentary bedrock of rhyolitic and andesitic composition affected by Carboniferous hydrothermal ...
Tópico(s): Geology and Paleoclimatology Research
2010 - Elsevier BV | Icarus
Javier Ruíz, Carlos Fernández, David Gómez-Ortíz, J. M. Dohm, Valle López, Rosa Tejero,
Surface heat flow calculations for the Amenthes region of Mars can be independently performed using the depth to the brittle–ductile transition and the effective elastic thickness of the lithosphere estimated for the Late Noachian/Early Hesperian (equivalent to an estimated absolute age of ∼ 3.6–3.8 Ga). This, along with crustal heat production rates estimated from heat-producing elements abundances, permits us to put constraints, for that particular place and time, on both the thermal and mechanical ...
Tópico(s): Geological and Geochemical Analysis
2008 - Elsevier BV | Earth and Planetary Science Letters
Theresa Byrd, Katherine Wilson, Judith Lee Smith, Gloria D. Coronado, Sally W. Vernon, Maria Eugenia Fernandez‐Esquer, Beti Thompson, Melchor Ortiz, David R. Lairson, María E. Fernández,
Abstract BACKGROUND: Considerable efforts have been undertaken in the United States to reduce cervical cancer incidence and mortality by increasing screening; however, disparities in screening rates continue to exist among certain racial and ethnic minority groups. The objective of the current study was to determine the effectiveness of a lay health worker‐delivered intervention—AMIGAS ( Ayudando a las Mujeres con Informacion, Guia, y Amor para su Salud [helping women with information, guidance, and ...
Tópico(s): Colorectal Cancer Screening and Detection
2012 - Wiley | Cancer
Irma Silva‐Zolezzi, Alfredo Hidalgo‐Miranda, Jesús K. Estrada-Gil, Juan Carlos Fernández-López, Laura Uribe-Figueroa, Alejandra Contreras‐Manzano, Eros Balam-Ortiz, Laura del Bosque‐Plata, David Velázquez‐Fernández, Cesar Lara, Rodrigo Goya, Enrique Hernández-Lemus, Carlos Dávila, Eduardo Barrientos, Santiago March, Gerardo Jiménez‐Sánchez,
Mexico is developing the basis for genomic medicine to improve healthcare of its population. The extensive study of genetic diversity and linkage disequilibrium structure of different populations has made it possible to develop tagging and imputation strategies to comprehensively analyze common genetic variation in association studies of complex diseases. We assessed the benefit of a Mexican haplotype map to improve identification of genes related to common diseases in the Mexican population. We ...
Tópico(s): Genetic diversity and population structure
2009 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Jamal El Haskouri, José Manuel Morales, David Ortiz de Zárate, Lorenzo Fernández, Julio Latorre, Carmen Guillem, Aurelio Beltrán, Daniel Beltrán, Pedro Amorós,
Nanoparticulated bimodal porous silicas (NBSs) with pore systems structured at two length scales (meso- and large-meso-/macropores) have been prepared through a one-pot surfactant-assisted procedure by using a simple template agent and starting from silicon atrane complexes as hydrolytic inorganic precursors. The final bulk materials are constructed by an aggregation of pseudospherical mesoporous primary nanoparticles process, over the course of which the interparticle (textural) large pore system ...
Tópico(s): Aerogels and thermal insulation
2008 - American Chemical Society | Inorganic Chemistry
David Ortiz de Zárate, Lorenzo Fernández, Aurelio Beltrán, Carmen Guillem, Julio Latorre, Daniel Beltrán, Pedro Amorós,
A diversity of silica-based and non-silica nanoparticulated mesoporous xerogels have been synthesized from aqueous solution using a surfactant-free strategy, and starting from molecular atrane complexes as precursors. This approach constitutes an extension of the "atrane route" previously described for the surfactant-assisted synthesis of mesoporous materials, and allows us to unify the multiplicity of protocols described for the preparation of conventional xerogels. In fact, we have used exactly ...
Tópico(s): Zeolite Catalysis and Synthesis
2007 - Elsevier BV | Solid State Sciences
David González‐Serna, Lourdes Ortiz‐Fernández, Sofía Vargas, Antonio Delgado, Enrique Raya, Benjamín Fernández‐Gutiérrez, Francisco Javier López‐Longo, Alejandro Balsa, Isidoro González‐Álvaro, Javier Narváez, Carmen Gómez‐Vaquero, José Mario Sabio, Rosa García-Portales, María Francisca González‐Escribano, Carles Tolosa, Patrícia Carreira, Lambertus A. Kiemeney, Marieke J. H. Coenen, Torsten Witte, M. Schneider, Miguel Á. González‐Gay, Javier Martı́n,
A rare variant (BAFF-var) of the tumor necrosis factor superfamily 13b (TNFSF13B) gene has been recently associated with multiple sclerosis (MS) and systemic lupus erythematosus (SLE). The aim of this study was to investigate the association between TNFSF13B BAFF-var and susceptibility to rheumatoid arthritis (RA) and replicate that association in SLE. 6,218 RA patients, 2,575 SLE patients and 4,403 healthy controls from three different countries were included in the study. TNFSF13B BAFF-var was genotyped ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2018 - Nature Portfolio | Scientific Reports
David Fernández‐Antorán, Maitane Ortiz, Lorena Rodríguez, Arancha Rodríguez García, Dolores Martínez, Ignacio Moreno de Alborán,
The immune response involves the generation of Ab-secreting cells and memory B cells through a process called terminal B lymphocyte differentiation. This program requires the transcriptional repressor Blimp-1, which inhibits c-myc expression and terminates proliferation. Although the role of c-Myc in cell proliferation is well characterized, it is not known whether it has other functions in terminal differentiation. In this study, we show that c-Myc not only regulates cell proliferation, but it ...
Tópico(s): Immunotherapy and Immune Responses
2013 - American Association of Immunologists | The Journal of Immunology
A. Pérez‐Guardiola, Ricardo Ortiz, María Eugenia Sandoval‐Salinas, J. Fernández‐Rossier, David Casanova, Á. J. Pérez‐Jiménez, J. C. Sancho-Garcı́a,
We systematically investigate the relationships between structural and electronic effects of finite size zigzag or armchair carbon nanotubes of various diameters and lengths, starting from a molecular template of varying shape and diameter, i.e. cyclic oligoacene or oligophenacene molecules, and disclosing how adding layers and/or end-caps (i.e. hemifullerenes) can modify their (poly)radicaloid nature. We mostly used tight-binding and finite-temperature density-based methods, the former providing ...
Tópico(s): Molecular Junctions and Nanostructures
2019 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Alexánder Berrocal, Johanna Gaitán-Álvarez, Róger Moya, David Fernández-Sólis, Edgar Ortíz‐Malavassi,
Tópico(s): Wood Treatment and Properties
2018 - Springer Science+Business Media | Journal of Forestry Research
Francisco D. Guillén‐Gámez, Ma José Mayorga-Fernández, Javier Bravo, David Escribano-Ortiz,
Tópico(s): E-Learning and Knowledge Management
2020 - Springer Science+Business Media | Technology Knowledge and Learning
David Jacob, Ricardo Ortiz, J. Fernández‐Rossier,
We study spin excitations and the Kondo effect in open-shell nanographenes, motivated by recent scanning tunneling inelastic spectroscopy experiments. Specifically, we consider three systems: the triangulene, the extended triangulene with rocket shape, both with an $S=1$ ground state, and a triangulene dimer with $S=0$ on account of intermolecular exchange. We focus on the consequences of hybridization of the nanographene zero modes with a conducting substrate on the $dI/dV$ line shapes associated ...
Tópico(s): Topological Materials and Phenomena
2021 - American Physical Society | Physical review. B./Physical review. B
Carmen Ortiz, Ruth Meneses, David Jaffe, John A. Fernandez, Guido O. Pérez, Jacques J. Bourgoignie,
Fifty-one adults with HIV infection, including 20 chronic hemodialysis patients with superimposed HIV infection and 31 patients with HIV-associated nephropathy requiring chronic maintenance hemodialysis were followed to evaluate survival on outpatient dialysis in relation to the clinical stage of the HIV infection. Regardless of when they contracted the infection, AIDS patients who required maintenance hemodialysis had a poor prognosis. All 17 patients who developed AIDS died after a mean of 93 +/- ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
1988 - Elsevier BV | Kidney International
Isidoro González‐Álvaro, Carmen Domı́nguez-Jiménez, Ana M. Ortiz, Vanessa Núñez, Pedro Roda‐Navarro, Elena Fernández-Ruíz, David Sancho, Francisco Sánchez‐Madrid,
Abstract We have characterized the lymphocyte subset and the receptor molecules involved in inducing the secretion of TNF by monocytic cells in vitro . The TNF secreted by monocytic cells was measured when they were co-cultured with either resting or IL-15-stimulated lymphocytes, T cells, B cells or natural killer (NK) cells isolated from the peripheral blood of healthy subjects and from the synovial fluid from patients with inflammatory arthropathies. Co-culture with IL-15-activated peripheral blood ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2006 - BioMed Central | Arthritis Research & Therapy
Emilio Pérez‐Pacheco, Víctor M. Moo‐Huchin, Raciel Javier Estrada‐León, A. Ortiz-Fernández, L.H. May-Hernández, Carlos Rolando Ríos‐Soberanis, David Betancur‐Ancona,
In this paper, the Ramon starch was isolated and its chemical composition and physical and microscopic characteristics were determined. Corn starch was used as reference. In general, the proximal composition was similar between starches studied. Ramon starch granules were oval–spherical and rounded with sizes between 6.5 and 15 μm. Starch purity was high (92.57%) with amylose content of 25.36%. The gelatinization temperature was 83.05 °C and transition enthalpy was 21.423 J/g. At 90 °C, solubility ...
Tópico(s): Microbial Metabolites in Food Biotechnology
2013 - Elsevier BV | Carbohydrate Polymers
Azucena Reyes-Pérez, Hugo Sánchez-Aguilar, David Velázquez‐Fernández, Donají Rodríguez-Ortiz, Maureen Mosti, Miguel F. Herrera,
Tópico(s): Gastroesophageal reflux and treatments
2015 - Springer Science+Business Media | Obesity Surgery
Soledad Cuezva, Ángel Fernández‐Cortés, David Benavente, Penélope Serrano‐Ortiz, Andrew S. Kowalski, Sergio Sánchez Moral,
This study tests the hypothesis that the degree of moisture in the soil pore system determines gas exchange processes (ventilation/charge) between the outer atmosphere and the karst-epikarst during the warm, dry period (summer). These processes explain "anomalous" CO2 fluxes measured over this and other ecosystems. Emission of CO2 by ventilation of cavities requires an open double membrane system (host rock and soil) through which air movement can take place (H2Ovapour, CO2, 222Rn, etc.). An experimental ...
Tópico(s): Plant Water Relations and Carbon Dynamics
2010 - Elsevier BV | Atmospheric Environment
Ricardo Amils, David C. Fernández‐Remolar, Vı́ctor Parro, J. A. Rodríguez‐Manfredi, Ken Timmis, Mónica Oggerin, Mónica Sánchez‐Román, Francisco J. López, José Pablo Fernández, Fernando Puente‐Sánchez, David Gómez-Ortíz, Carlos Briones, Felipe Gómez, Enoma O. Omoregie, M. García, Núria Rodríguez, J. L. Sanz,
The geomicrobiological characterization of Río Tinto, an extreme acidic environment, has proven the importance of the iron cycle, not only in generating the extreme conditions of the habitat (low pH, high concentration of toxic heavy metals) but also in maintaining the high level of microbial diversity detected in the water column and the sediments. The extreme conditions detected in the Tinto basin are not the product of industrial contamination but the consequence of the presence of an underground ...
Tópico(s): Mine drainage and remediation techniques
2013 - Trans Tech Publications | Advanced materials research
Alvaro Sponza, Natalia J. Fernández, David J. Yang, Karla A. Ortiz, Abel E. Navarro,
Chemical modifications of clay to remove methylene blue (MB) from aqueous solutions at room temperature were compared. Natural bentonite (NC) was modified by cation exchange with hexadecyltrimethylammonium chloride (HC), bencyltriethylammonium chloride (BC), and tetramethylammonium chloride (TC) to reverse the surface polarity of the hydrophilic bentonite. The adsorption of MB was studied and fitted by the adsorption theories of Langmuir, Freundlich, Dubinin-Radushkevich, and Temkin. Equilibrium parameters ...
Tópico(s): Adsorption, diffusion, and thermodynamic properties of materials
2015 - Multidisciplinary Digital Publishing Institute | Environments
Kenneth M. Lanzetta, Arthur M. Wolfe, Hakan Altan, X. Barcons, Hsiao‐Wen Chen, A. Fernández-Soto, David M. Meyer, A. Ortiz-Gil, S. Savaglio, John K. Webb, Noriaki Yahata,
We report new HST and ground-based observations of a damped Lyα absorption system toward the QSO 0850+4400. The redshift of the absorption system is ζ=0.l63770±0.000054 and the neutral hydrogen column density of the absorption system is log N=19.81±0.04 cm -2 . The absorption system is by far the lowest redshift confirmed damped Lyα absorption system yet identified, which provides an unprecedented opportunity to examine the nature, impact geometry, and kinematics of the absorbing galaxy in great detail. ...
Tópico(s): Astronomy and Astrophysical Research
1997 - Institute of Physics | The Astronomical Journal
Juan Fernández‐Armenta, Antonio Berruezo, Jose T. Ortiz‐Pérez, Lluı́s Mont, David Andreu, Csaba Herczku, Tim Boussy, Josép Brugada,
... and Coronary Arteries Into the Navigation System Juan Fernández-Armenta, MD, Antonio Berruezo, MD, PhD, Jose T. Ortiz-Pérez, MD, PhD, Lluis Mont, MD, PhD, David Andreu, MSc, Csaba Herczku, MD, Tim Boussy, MD and Josep Brugada, MD, PhD Juan Fernández-ArmentaJuan Fernández-Armenta From the Arrhythmia Section, Cardiology ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2012 - Lippincott Williams & Wilkins | Circulation
Boris Brumshtein, Matilde Aguilar‐Moncayo, M. Isabel García‐Moreno, Carmen Ortiz Mellet, José M. Garcı́a Fernández, Israel Silman, Yoseph Shaaltiel, David Aviezer, Joel L. Sussman, Anthony H. Futerman,
Abstract 6‐Amino‐6‐deoxy‐5,6‐di‐ N ‐( N ′‐octyliminomethylidene)nojirimycin , a reducing analogue of N ‐nonyl‐1‐deoxynojirimycin, proved to be a potent and very selective inhibitor of β‐glucosidases, including human acid β‐glucosidase. Structural studies of the enzyme–inhibitor complex showed a binding mode in which the anomeric hydroxy group is accommodated in the “wrong” α configuration. magnified image
Tópico(s): Legume Nitrogen Fixing Symbiosis
2009 - Wiley | ChemBioChem
Miguel Vázquez‐Moreno, Helen Zeng, Daniel Locia‐Morales, Jesús Peralta‐Romero, Hamza Asif, Arjuna Maharaj, Vivian Tam, María del Socorro Romero-Figueroa, Gloria Patricia Sosa-Bustamante, Socorro Méndez‐Martínez, Aurora Mejía‐Benítez, Adán Valladares‐Salgado, Niels H. Wacher, Andrea Socorro Álvarez Villaseñor, Kelly G Acosta, Raquel Flores-Torrecillas, Uriel Flores-Osuna, Mariell G García-Avilés, Roxana González‐Dzib, René A Gameros-Gardea, María Luisa Pizano-Zárate, Jorge A. Núñez-Hernández, Verónica de León-Camacho, Roberto Karam-Araujo, Perla Corona-Salazar, Fernando Suárez‐Sánchez, Jaime Gómez-Zamudio, Eugenia Flores‐Alfaro, Arturo Reyes-Hernández, Catalina Peralta-Cortázar, Emmanuel G Martínez-Moralesvalla, Luz V Díaz de León Morales, Irma L del C González-González, Arturo Maximiliano Reyes-Sosa, Sonia Lazcano-Bautista, María Georgina Arteaga-Alcaraz, Nandy García-Silva, Moisés Herrera-Lemus, Gress Marissell Gómez Arteaga, Anel Gómez‐García, Martha V Urbina-Treviño, Diana Carolina Villalpando Sánchez, Cleto Álvarez-Aguilar, Ramón Ernesto Jiménez-Arredondo, Martha I. Dávila‐Rodríguez, Francisco González‐Salazar, Laura Hermila de la Garza-Salinas, Aleyda Pérez‐Herrera, Jorge Martínez-Torres, Elizabeth Méndez-Fernández, Víctor A. Segura-Bonilla, Mariana Gutiérrez-Hernández, Lilia Susana Gallardo-Vidal, Leticia Blanco Castillo, José J. García-González, Julio Medina‐Serrano, Adrian Canizalez‐Román, Cruz Mónica López-Morales, Jaime Valle-Leal, Martin Segura-Chico, Rafael Violenté-Ortiz, Verónica Fernández-Jiménez, Norma A Sánchez-Hernández, Miguel Cruz, David Meyre,
Abstract Context Rare partial/complete loss-of-function mutations in the melanocortin-4 receptor (MC4R) gene are the most common cause of Mendelian obesity in European populations, but their contribution to obesity in the Mexican population is unclear. Objective and Design We investigated whether deleterious mutations in MC4R contribute to obesity in Mexican children and adults. Results We provide evidence that the MC4R p.Ile269Asn (rs79783591) mutation may have arisen in modern human populations ...
Tópico(s): Genetic Associations and Epidemiology
2019 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Elena Ortiz‐Zapater, David Pineda, Neus Martínez‐Bosch, Gonzalo Fernández‐Miranda, Mar Iglesias, Francesc Alameda, Mireia Moreno, Carolina Eliscovich, Eduardo Eyras, Francisco X. Real, Raúl Méndez, Pilar Navarro,
Tópico(s): RNA and protein synthesis mechanisms
2011 - Nature Portfolio | Nature Medicine
David C. Fernández‐Remolar, David Gómez-Ortíz, Per Malmberg, Ting Huang, Shen Yan, Angélica Anglés, Ricardo Amils,
The drilling of the Rio Tinto basement has provided evidence of an underground microbial community primarily sustained by the Fe and S metabolism through the biooxidation of pyrite orebodies. Although the gossan is the microbial activity product, which dates back to the Oligocene (25 Ma), no molecular evidence of such activity in the past has been reported yet. A Time of Flight Secondary Ion Mass Spectrometry (ToF-SIMS) molecular analysis of a subsurface sample in the Peña de Hierro basement has provided ...
Tópico(s): Geochemistry and Elemental Analysis
2021 - Multidisciplinary Digital Publishing Institute | Microorganisms
David Andreu, Jose T. Ortiz‐Pérez, Juan Fernández‐Armenta, Esther Guiu, Juan Acosta, S Prat, Teresa M. de Caralt, Rosario J. Perea, César Garrido, Lluı́s Mont, Josép Brugada, Antonio Berruezo,
AimsNon-invasive depiction of conducting channels (CCs) is gaining interest for its usefulness in ventricular tachycardia (VT) ablation. The best imaging approach has not been determined. We compared characterization of myocardial scar with late-gadolinium enhancement cardiac magnetic resonance using a navigator-gated 3D sequence (3D-GRE) and conventional 2D imaging using either a single shot inversion recovery steady-state-free-precession (2D-SSFP) or inversion-recovery gradient echo (2D-GRE) sequence.
Tópico(s): Cardiac electrophysiology and arrhythmias
2015 - Oxford University Press | EP Europace