Michael Winton, Peter Bath and Wells, John Chelmsford, Colin Coventry, Michael Exon, Andrew Robson, Tony Shields, Widget Finn, Carol Lewis, Peter Kllnger, Robert Cole, Joe Harrison, Neelam Verjee, Morag Dalziel, Greg Hurst Political Correspondent, Peter Lansley, Christopher Wood, Mark Souster, Oscar MacAulay, Robert Garmston, David G. Dodd, Cristina Odone, Philip Howard, Hilary Finch, David Chater, Michael Horsnell and Michael Evans Defence Editor, Rachel Campbell-Johnston, James Bone, Tom Baldwin and Frances Gibb, Nic Hopkins, Clive Davis, Alexandra Frean Social Affairs Correspondent, Richard Irving, Gabrielle Starkey, Graham Small, Carl Mortished, Sam Marlowe, Phyllis Pease, Geoff Brown, Joe Joseph, Andrew Norfolk, Pat Gibson, David McVay, Valerie Elliott, Anthony Browne, Jack Malvern, Dominic Walsh, James Doran Wall Street Correspondent, Angela Jameson Industrial Correspondent, Dalya Alberge Arts Correspondent, Nicholas Blanford, Alan Hamilton, Joey Kwong, David Michael, Dominic kennedy, Anatole Kaletsky, Richard Lloyd Parry, David Tucker, David Hands, Ian MacKinnon, Ron Lewis, Peter Galloway, Matt Dickinson Chief Football Correspondent, Liz Chong, Caroline Merrell Banking Correspondent, Ellzabeth Judge Telecoms Correspondent, Angela Jameson, Russell Kempson, Tony Halpin Education Editor, Oliver Kay, John A. Kohan, David Lister, Lisa Armstrong, James bone, Rick Broadbent, Patrick Hosking Investment Editor, Tom Baldwin, Michael Evans Defence Editor and Michael Horsnell, Ann Treneman, Simon de Bruxelles, John Hopkins Golf Correspondent, Ronald Watson and Roger Boyes, Raymond Keene, Sue Ellicott, Lewis Smith, Richard Lambert, Matthew Pryor, Lewis Stuart and David Hands, Sean MacAulay, William Garrett, Stuart Newton, Clare Short, Xan Rice, Jeremy Page, Chris Campling, Roger Boyes, Tony Elven, Gabriel Rozenberg Economics Reporter, Richard Mills, Nick Hasell, Richard lrving, David Hands Rugby Correspondent, Owen Slot Chief Sports Reporter, Tony Cascarino, Julian Muscat, Paul Simons, Michelle Henery, Robin Anderson, Jonathan Clayton, Philip Webster Political Editor, Giles Whittell, Graham Searjeant Financial Editor, Kenichi Ohmae, Angus MacLeod, Anjana Ahuja, George Caulkin, Neil Fisher, Peter Riddell, Glynis Lee, Tony Dawe, Carly Chynoweth, Richard Beeston Diplomatic Editor, David Veale, Graham Searjeant, David Sinclair, Nicholas Lawrence, Clarissa Farr, Martin Waller, Carl Mortished International Business Editor, Laura Peek, Sarah Butler, Nigel Hawkes Health Editor, Alan Yau, Val Horsler, Benedict Nightingale, John B. Sheldon, Stephen Dalton, Ben Hoyle, David Powell, Alyson Rudd, Tony Halpin, James Christopher, Abigail Rayner, Bronwyn Cosgrave, Clare Dight, Alexandra Blair Education Correspondent, Sheldon Bowles, Richard and Susan Silvano, Thomas Stuttaford, John Brooks, Jenny Davey, Patience Wheatcroft, Cath Clarke, Raekha Prasad, Hannah Thorne,
The Times Legal blessing for the royal marriage Saddam nemesis 'Prank' drowning Career Food prosecution Springer threat BT kiosk hang-up Index Eighteen ...
2005 - Gale Group | TDA
Neeraj Dhaun, Jane Goddard, Donald E. Kohan, David M. Pollock, Ernesto L. Schiffrin, David J. Webb,
... Years On Neeraj Dhaun, Jane Goddard, Donald E. Kohan, David M. Pollock, Ernesto L. Schiffrin and David J. ... of Medicine (E.L.S.), Sir Mortimer B. David-Jewish General Hospital, McGill University, Montreal, Quebec, Canada. , Donald E. KohanDonald E. Kohan From the Clinical Pharmacology Unit (N.D., J.G., D.J.W.), University of Edinburgh, Queen's Medical Research Institute, Edinburgh, United Kingdom; Division of Nephrology (D.E.K.), University of Utah, Salt Lake City; Vascular Biology Center (D.M.P.), Medical College of Georgia, Augusta; and Department of Medicine (E.L.S.), Sir Mortimer B. David-Jewish General Hospital, McGill University, Montreal, Quebec, Canada. , ...
Tópico(s): Blood Pressure and Hypertension Studies
2008 - Lippincott Williams & Wilkins | Hypertension
By Paul Routledge Labour Editor, By George Clark Political Correspondent, By Melvyn Westlake, By Huon Mallalieu, By Fred Emery Political Editor, From Richard Davy, Richard Wigg, By Our Political Editor, By Dan van der Vat, By Donald Macintyre Labour Reporter, By Our Political Staff, From Our Correspondent, By Michael Horsnell, By Stewart Tendler Crime Reporter, By Peter Hennessy, By Annabel Ferriman Health Services Correspondent, By Diana Geddes Education Correspondent, By Clifford Longley Religious Affairs Correspondent, By Pearce Wright Science Editor, By Our Education Correspondent, By Sarah Segrue, By Frances Gibb, By John Young Planning Reporter, From Christopher Thomas, By John Witherow, By Lucy Hodges, By Pat Healy Social Services Correspondent, By Hugh Clayton Agriculture Correspondent, By Ian Bradley, By Peter Waymark Motoring Correspondent, From Charles Hargrove, From Patricia Clough, From Gretel Spitzer, From Harry Debelius, by Arrigo Levi, From Michael Binyon, From Christopher Walker, From Our Own Correspondent, From David Spanier Diplomatic Correspondent, From Clive Cookson, From Nicholas Ashford, By George Clark, , From Jacqueline Reditt, From Michael Hornsby, From Sue Masterman, From Peter Hazelhurst, From Hasan Akhtar, From David Watts, By George Clark, Political Correspondent, Prudence Glynn, Shona Crawford Poole, William Mann, Paul Griffiths, Noël Goodwin, John Russell Taylor, John Rowlands, Irving Wardle, Ned Chaillet, Martin Huckerby, By Norman Fox Football Correspondent, By Sydney Friskin, By Philip Webster, By Roy McKelvie, By John Nicholls, By Peter West Rugby Correspondent, By Keith Macklin, By Rex Bellamy Tennis Correspondent, Ronald Butt, Bernard Levin, Alan Hamilton, Donald Macintyre, H. B. GIBSON, , PATRICK MARTIN-SMITH, , C. L. L. CLARKE, , ALAN BULLOCK, , CHRISTOPHER BLAND, , D. R. DENNE, , BROOKES, , DOUGLAS DALE, , ALAN MAYNARD, , H. BRENDAN DEVLIN, , JACK STRAW, , S. H. PIERCE, , R. B. MARRIOTT, , CORNELLIUS O'LEARY, STELLA MARY NEWTON, , JOHN HOUSDEN, , By the Staff of Nature, By Our Music Reporter, From Our Special Correspondent, Mr Howard Thomas, Viscount Caldecote, Richard Holmes, Charles Wintour, Peter Tinniswood, H. R. F. Keating, Jill Craigie, By Arthur Reed Air Correspondent, By Peter Hill Industrial Editor, By Frances Williams, Frank Vogl, By Patricia Tisdall Management Correspondent, By Margareta Pagano, By Roman Eisenstein Banking Correspondent, By Michael Prest Mining Correspondent, By Richard Allen, By John Whitmore Financial Correspondent, By David Felton Labour Reporter, Karan Thapar, By David Hewson, , By Edward Townsend, From Derek Harris, By Hugh Clayton Agricultural Correspondent, W. S. HILL, , R. A. S. GIMSON, , LUCIE CLAYTON, , D. T. ROBERTS, , P. SEDGWICK, , BY THE FINANCIAL EDITOR, Ross Davies, David Blake, By Bryan Appleyard, By Our Financial Staff, By Rosemary Unsworth, By Richard Allen Insurance Correspondent, By Peter Wilson-Smith, Edited by Peter Dear, Jacques Grail, Melvyn Westlake, Hugh Clayton, Inge Adham, Max Rives, Livio Burato, Walter Spiegel, Peter Strafford, Saskia Martin, Josée Doyère, Didier Guerin,
... Collins, £6.95) Hand-Me-Downs By Rhea Kohan, Improvisation with necessary spectating collaboration Amazing Comedy Show ...
1980 - Gale Group | TDA
J. David Smeijer, Donald E. Kohan, David J. Webb, Neeraj Dhaun, Hiddo J.L. Heerspink,
Purpose of review To summarize new clinical findings of endothelin receptor antagonists (ERA) in various etiologies of kidney disease targeted in clinical trials. Recent findings Endothelin-1 is a multifunctional peptide with potential relevance to glomerular and tubulointerstitial kidney diseases. The phase 3 SONAR trial demonstrated a significant reduction in clinically relevant kidney outcomes for patients with diabetic kidney disease (DKD) after long-term treatment with the ERA, atrasentan, in ...
Tópico(s): Nitric Oxide and Endothelin Effects
2021 - Lippincott Williams & Wilkins | Current Opinion in Nephrology & Hypertension
BY A STAFF REPORTER, FROM OUR OWN CORRESPONDENT, BY OUR POLITICAL STAFF, FROM OUR CORRESPONDENT, BY OUR LABOUR STAFF, By ARTHUR REED, Air Correspondent, FROM OUR CORRESPONDENT-, BY PHILIP HOWARD, From WILLAM NORRIS, Africa Correspondent, FROM OUR COMMONWEALTH STAFF, From DAVID SPANIER, FROM OUR SPECIAL CORRESPONDENT, FROM A SPECIAL CORRESPONDENT, New York, Aug. 14, From DAVID BONAVIA, By Guy Brett, by Stanley Sadie, By Marese Murphy, By Michael Billington, From Our Special Correspondent, From PAUL HORNE, JOHN HENNESSY, P.H.S., A. NOVE., L. S. MURPHY., E. H. THOMPSON. Ward 52, University College Hospital, W.C.1. Aug. 12., C. NORTHCOTE., GLADWYN. Bramfield Hall, Halesworth, Suffolk, Aug. 12., J. F. ORJOLLET., A. E. E. READE, late Major, Intelligence Corps. Les Petites Vagues, Pontác, Jersey, Channel Islands, Aug. 11., BRIAN JOHNSON-FERGUSON. Solwaybank, Half Morton, Canonbie, Dumfriesshire, Aug. 13., RAYMOND LEPPARD. Trinity College, Cambridge, Aug. 11., By Evan Charlton, LESLIE FREEMAN, Chairman, General Purposes Committee Greater London Council. The County Hall, S.E.1, Aug. 12., CYRIL E. S. HORSFORD, Director (U.K.), International Institute of Space Law. 11 Buckleigh Way, S.E.19., ALEXANDER W. LYON. House of Commons, Aug. 13., MARY HULL. 72 Ruskin Walk, S.E.24, Aug. 9., NORBERT SAKOWSKI, News Editor, Stern Magazine, Pressehaus, Hamburg, 1., NORMAN LINDOP. Parkhotel Schoenegg, Grindelwald, Aug. 9., C. J. HARRIS. Oxnead Hall, Oxnead, Norwich, Norfolk., FROM A STAFF REPORTER, FROM OUR CHESS CORRESPONDENT, An ex-colleague, From REX BELLAMY, Tennis Correspondent, From CHARLES BRAY, By DOUGLAS CALDER, From JIM SNOW, By KEITH PAYNE, By JOHN CARRINGTON, By JOHN GILMORE and RICHARD SPIEGELBERG, By CLIFFORD WEBB, Midland Industrial Correspondent, BY OUR BANKING CORRESPONDENT, By R. W. SHAKESPEARE, Northern Industrial Correspondent, From HENRY SCOTT STOKES, BY THE FINANCIAL EDITOR, E. G. A. GRIMWOOD, Managing Director, John D. Hutchison (U.K.) Limited. Windsor House, 1270 London Road, Norbury, London, S.W.16, W. SHAW. 22 Glenville Avenue, Glenfield, Leicester.,
... Shore Preservation of old structures, Mr R. M. Kohan, Mr Bob Anderson Noted racing driver. Sport: Young ...
1967 - Gale Group | TDA
Vartan S. Tashjian, E. Kohan, David L. McArthur, Langston T. Holly,
Cervical spondylotic myelopathy represents a debilitating disorder, often resulting in significant neurological impairment over time. Cervical laminectomy has enjoyed a successful track record in the surgical management of these patients. Little is understood regarding the significance of postdecompressive migration of the spinal cord in relation to patient outcome.Preoperative and postoperative cervical spine MRIs of 28 patients who underwent cervical laminectomy and fusion for the treatment of ...
Tópico(s): Spinal Fractures and Fixation Techniques
2009 - Elsevier BV | Surgical Neurology
FROM OUR OWN CORRESPONDENT, From PETER STRAFFORD, From WILLIAM MORRIS, FROM OUR CORRESPONDENT, By HUGH CORBET, FROM OUR COMMONWEALTH STAFF, BY A STAFF REPORTER, FROM OUR NORTHERN CORRESPONDENT, By BRIAN MacARTHUR, Education Correspondent, BY OUR LABOUR STAFF, By MICHAEL THOMAS, From JOHN CHARTRES, FROM OUR BROADCASTING CORRESPONDENT, From WILLIAM NORRIS, , By CHARLES DOUGLASHOME, Defence Correspondent, From DAVID SPANIER, , FROM LAWRENCE FELLOWS, From M. S. HANDLER-, By Stanley Sadie, From our Museums Correspondent, By John Percival Ballet Critic, By Michael Billington, FROM A SPECIAL CORRESPONDENT, ROY LEWIS, By NORMAN FOWLER, Home Affairs Correspondent, PHS, S. W. ROSKILL. Churchill College, Cambridge, Aug. 9., ROBERT MOSS. Wellington College, Berkshire., RENWICK. Chairman, British Space Development Company Limited. A.T.V. House, 17 Great Cumberland Place, W.1, Aug. 10., A. P. HERBERT, Chairman, British Copyright Council, President, the Society of Authors. 12 Hammersmith Terrace, W.6, Aug. 9., IAN ORR-EWING. House of Commons, Aug. 10., ROGER GAYMER. Department of Zoology, University of Bristol, Aug. 9., HUGH JENKINS. House of Commons, Aug. 9., ANTHONY ROYLE. House of Commons, Aug. 7., By CHRISTOPHER MARTIN, O. N. EMERUWA. 21 Montague Avenue, S.E.4, Aug. 9., C. R. VERNER. The Red House, Hindon, Salisbury, Wiltshire, Aug. 5., O. VESEY HOLT. Phantom Ranch, North Chailey, Lewes, Sussex., ANTHONY BULL. Vice-Chairman, London Transport Board. 55 Broadway, Westiminster, S.W.1., T. S. STALLABRASS. Tremorna, St. Ives, Cornwall., GEOFFREY DE FREITAS. House of Commons., BY PHILIP HOWARD, FROM OUR CHESS CORRESPONDENT, Barbara Fox, From TIM JONES, From JIM SNOW, From JOHN WOODCOCK, Cricket Correspondent, From PETER RYDE, Golf Correspondent, From Our Special Correspondent, From PAMELA MACGREGOR MORRIS, From GENEVIEVE MURPHY, From REX BELLAMY, Tennis Correspondent, FROM OUR SPECIAL CORRESPONDENT, FROM OUR NORTHERN INDUSTRIAL CORRESPONDENT, By KENNETH OWEN, BY THE FINANCIAL EDITOR, By PHILIP JACOBSON, BY OUR BANKING CORRESPONDENT, KEITH ORD, Managing Director. Keith Z. Ord & Co. Ltd., 29 Broadfields, East Molesey, Surrey., By RICHARD FRY, By GEORGE PULAY, City Editor,
... Weinberger, Mr J. J. Horgan, Major C. M. Kohan. Weather: The Weather. Property: The brighter side of ...
1967 - Gale Group | TDA
Donald E. Kohan, David M. Pollock,
Numerous pre‐clinical studies have implicated endothelin‐1 in the pathogenesis of diabetic and non‐diabetic chronic kidney disease ( CKD ). Renal endothelin‐1 production is almost universally increased in kidney disease. The pathologic effects of endothelin‐1, including vasoconstriction, proteinuria, inflammation, cellular injury and fibrosis, are likely mediated by the endothelin A ( ETA ) receptor. ETA antagonism alone, and/or combined ETA / B blockade, reduces CKD progression. Based on the strong pre‐clinical ...
Tópico(s): Renal function and acid-base balance
2012 - Wiley | British Journal of Clinical Pharmacology
Kelly A. Hyndman, Erika I. Boesen, Ahmed A. Elmarakby, Michael W. Brands, Paul L. Huang, Donald E. Kohan, David M. Pollock, Jennifer S. Pollock,
Nitric oxide is a pronatriuretic and prodiuretic factor. The highest renal NO synthase (NOS) activity is found in the inner medullary collecting duct. The collecting duct (CD) is the site of daily fine-tune regulation of sodium balance, and led us to hypothesize that a CD-specific deletion of NOS1 would result in an impaired ability to excrete a sodium load leading to a salt-sensitive blood pressure phenotype. We bred AQP2-CRE mice with NOS1 floxed mice to produce flox control and CD-specific NOS1 ...
Tópico(s): Renal function and acid-base balance
2013 - Lippincott Williams & Wilkins | Hypertension
Beau P. Sperry, Aaron Conger, Lynn Kohan, David R. Walega, Steven P. Cohen, Zachary L. McCormick,
Tópico(s): Orthopedic Surgery and Rehabilitation
2020 - Oxford University Press | Pain Medicine
Kurt McCammon, Angelo E. Gousse, Alfred Kohan, David B. Glazier, Jennifer Gruenenfelder, Zhanying Bai, Anand Patel, Douglass S. Hale,
Objectives This randomized, multicenter, placebo-controlled, phase IV study assessed the efficacy and tolerability of onabotulinumtoxinA in patients with overactive bladder. Methods Patients were randomized 1:1 to onabotulinumtoxinA 100 U or placebo. Assessments over 12 weeks included: change from baseline in urinary incontinence (UI) episodes/day; proportions of patients who achieved 100% and 50% or greater reductions in UI episodes/day; proportion of patients using no incontinence pads in the previous ...
Tópico(s): Urinary Tract Infections Management
2020 - Lippincott Williams & Wilkins | Female Pelvic Medicine & Reconstructive Surgery
... review>.Will and Grace. Cr. Max Mutchnick and David Kohan. Warner Bros. Television, 1998-2006, 2017 to present. ...
Tópico(s): Media, Gender, and Advertising
2018 - Queensland University of Technology | M/C Journal
Roohi Jeelani, Charalampos Chatzicharalampous, Hamid‐Reza Kohan‐Ghadr, David Bai, Robert T. Morris, Inga Sliskovic, Awoniyi O. Awonuga, Husam M. Abu‐Soud,
Caspase-3 is involved in apoptosis. Here, we examine whether hypochlorous acid (HOCl), a final product of myeloperoxidase (MPO), is a modulator of caspase-3 at relatively low concentrations and also its application on metaphase II mouse oocytes. We utilised caspase-3 activity assay, TUNEL assay, the CellEvent caspase 3/7 fluorescent assay, and the MPO/hydrogen peroxide (H2O2) system on mouse oocytes with and without cumulus cells to examine whether low concentrations of HOCl mediate apoptosis by inhibition ...
Tópico(s): Phagocytosis and Immune Regulation
2020 - Taylor & Francis | Free Radical Research
Li Yang, Xiaoming Li, Yong Ji, Alison B. Kohan, David Q.‐H. Wang, Philip N. Howles, David Y. Hui, Jianghua Lai, Patrick Tso,
Ezetimibe is a potent inhibitor of cholesterol absorption by enterocytes. Although ezetimibe minimally affects the absorption of triglyceride, it is unknown whether ezetimibe affects the secretion of the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). It has been shown that ezetimibe-treated mice are protected from diet-induced insulin resistance. Since GIP and GLP-1 promote the actions of insulin, we hypothesized that ezetimibe may affect ...
Tópico(s): Cholesterol and Lipid Metabolism
2010 - American Physiological Society | AJP Gastrointestinal and Liver Physiology
Tobias Strunk, Dorota A. Doherty, Angela Jacques, Karen Simmer, Peter Richmond, Rolland Kohan, Adrian Charles, David Burgner,
Background: Histologic chorioamnionitis (HCA) is implicated in the onset of preterm labor and delivery. Chorioamnionitis is a known risk factor for early-onset sepsis and may modulate postnatal immunity. Preterm infants are at greatly increased risk of late-onset sepsis (LOS), particularly with coagulase-negative staphylococci (CoNS), but the impact of HCA on the risk of LOS is unknown. Methods: Eight hundred thirty-eight preterm infants born at <30 weeks gestational age at a single tertiary center ...
Tópico(s): Neonatal Respiratory Health Research
2011 - American Academy of Pediatrics | PEDIATRICS
Raquel Rodríguez‐Carvajal, Carlos Rosas, Karla Kohan, Fernando Gabler, David Vantman, Carmen Romero, Margarita Vega,
Does treatment with the insulin sensitizer metformin modify the levels and activation of proteins related to the expression of the insulin-dependent glucose transporter (GLUT4), such as adenosine monophosphate-activated protein kinase (AMPK) and myocyte enhancer factor 2A (MEF2A), in endometria from hyperinsulinemic hyperandrogenemic polycystic ovary syndrome (PCOS h-Ins) patients? In PCOS h-Ins patients, metformin increases endometrial levels of GLUT4 mRNA and protein levels by normalizing the quantity ...
Tópico(s): Genetic Syndromes and Imprinting
2013 - Oxford University Press | Human Reproduction
Larry L. Hall, S. Elizabeth George, Michael J. Kohan, Miroslav Stýblo, David J. Thomas,
The capacity of mouse intestinal cecal microflora to methylate inorganic arsenicals (iAs) was examinedin vitrounder conditions of restricted bacterial growth. Cecal contents incubated under anaerobic conditions at 37°C for 21 hr methylated up to 40% of either 0.1 μmarsenite (iAsIII) or 0.1 μmarsenate (iAsV). Methylarsenic (MAs) was the predominant metabolite; however, about 3% of either substrate was converted to dimethylarsenic (DMAs). Over the first 6 hr, the rate of methylation was several times greater ...
Tópico(s): Fluoride Effects and Removal
1997 - Elsevier BV | Toxicology and Applied Pharmacology
Sean D. Conklin, Amanda H. Ackerman, Michael Fricke, Patricia A. Creed, John T. Creed, Michael C. Kohan, Karen Herbin-Davis, David J. Thomas,
This investigation examined chemical and microbiological transformations of an arsenosugar by mouse cecum. To mimic the low oxygen environment in the mammalian gastrointestinal tract, reaction mixtures were incubated under anaerobic conditions. An arsenosugar extracted from ribbon kelp, 3-[5′-deoxy-5-(dimethylarsinoyl)-β-ribofuranosyloxy]-2-hydroxypropanesulfonic acid, As(392), was added to reaction mixtures that contained either cecal microflora or cecal tissue homogenate. These reaction mixtures ...
Tópico(s): Selenium in Biological Systems
2006 - Royal Society of Chemistry | The Analyst
Heather R Trenary, Patricia A. Creed, Andrea R. Young, Madhavi Mantha, Carol A. Schwegel, Jianping Xue, Michael J. Kohan, Karen Herbin-Davis, David J. Thomas, Joseph A. Caruso, John T. Creed,
In this study, an in vitro synthetic gastrointestinal extraction protocol was used to estimate bioaccessibility of different arsenicals present in 17 rice samples of various grain types that were collected across the United States. The across matrix average for total arsenic was 209 ng/g±153 (\[xmacr]±2σ). The bioaccessibility estimate produced an across matrix average of 61%±19 (\[xmacr]±2σ). The across matrix average concentrations of inorganic arsenic (iAs) and dimethylarsinic acid (DMA) were 81 ng/g± ...
Tópico(s): Heavy metals in environment
2012 - Springer Nature | Journal of Exposure Science & Environmental Epidemiology
Anthony P. Davenport, Kelly A. Hyndman, Neeraj Dhaun, Christopher Southan, Donald E. Kohan, Jennifer S. Pollock, David M. Pollock, David J. Webb, Janet J. Maguire,
The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1 and -2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas endothelin-3 has a lower affinity for the ETA subtype. Genes encoding the peptides are present only among vertebrates. The ligand-receptor signaling pathway is a vertebrate innovation and may reflect the evolution of endothelin-1 as the most potent vasoconstrictor in the human cardiovascular system with remarkably long ...
Tópico(s): Pulmonary Hypertension Research and Treatments
2016 - American Society for Pharmacology and Experimental Therapeutics | Pharmacological Reviews
H. Bibi, Z. Gelman‐Kohan, E. R. Baumgartner, David S. Rosenblatt,
Tópico(s): Metabolism and Genetic Disorders
1999 - Springer Science+Business Media | Journal of Inherited Metabolic Disease
E. Kohan, David S. Oh, Hank Wang, Salar Hazany, Gordon Ohning, Joseph R. Pisegna,
Objectives. Zollinger-Ellison Syndrome (ZES) results in hypersecretion of gastric acid (via gastrinoma) leading to peptic ulcers, diarrhea, and abdominal pain. We describe the novel discovery of hypertrophic, heterotopic gastric mucosa in the proximal duodenal bulb in patients with ZES, which we hypothesize results in an increased incidence of postbulbar ulcers in patients with ZES (a mechanism previously unreported). We determined the incidence of the novel finding of duodenal gastric oxyntic hypertrophic ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2009 - Hindawi Publishing Corporation | Diagnostic and therapeutic endoscopy
Jennifer J. Griggs, Liang Chi, Nancy M. Hanley, Michael J. Kohan, Karen Herbin-Davis, David J. Thomas, Kun Lü, Rebecca C. Fry, Karen D. Bradham,
Arsenic exposure has been reported to alter the gut microbiome in mice. Activity of the gut microbiome derived from fecal microbiota has been found to affect arsenic bioaccessibility in an in vitro gastrointestinal (GI) model. Only a few studies have explored the relation between arsenic exposure and changes in the composition of the gut microbiome and in arsenic bioaccessibility. Here, we used simulated GI model system (GIMS) containing a stomach, small intestine, colon phases and microorganisms ...
Tópico(s): Fecal contamination and water quality
2022 - Elsevier BV | Environmental Pollution
Tess M. E. van Ramshorst, Jony van Hilst, Elisa Bannone, Alessandra Pulvirenti, Horacio J. Asbun, Ugo Boggi, Olivier R. Busch, Safi Dokmak, Bjørn Edwin, Melissa E. Hogg, Jin‐Young Jang, Tobias Keck, Igor Khatkov, Gustavo Kohan, Norihiro Kokudo, David A. Kooby, Masafumi Nakamura, John Primrose, Ajith K. Siriwardena, Christian Toso, Charles M. Vollmer, Herbert J. Zeh, Marc G. Besselink, Mohammad Abu Hilal,
BackgroundEvidence on the value of minimally invasive pancreatic surgery (MIPS) has been increasing but it is unclear how this has influenced the view of pancreatic surgeons on MIPS.MethodsAn anonymous survey was sent to members of eight international Hepato-Pancreato-Biliary Associations. Outcomes were compared with the 2016 international survey.ResultsOverall, 315 surgeons from 47 countries participated. The median volume of pancreatic resections per center was 70 (IQR 40–120). Most surgeons considered ...
Tópico(s): Minimally Invasive Surgical Techniques
2023 - Elsevier BV | HPB
Karla Kohan, Rodrigo Carvajal, Fernando Gabler, David Vantman, Carmen Romero, Margarita Vega,
Fifty to seventy percent of patients with polycystic ovary syndrome (PCOS) present hyperinsulinemia. On the other hand, reports indicate that forkhead box class O 1 (FOXO1) and peroxisome proliferator-activated receptor-γ (PPARG) are involved in the insulin signaling pathway, regulating the gene expression of SLC2A4 (GLUT4). The negative effect of FOXO1 over PPARG transcription disappears when FOXO1 is phosphorylated (p-FOXO1) and excluded from the nucleus, whereas PPARG can suppress gene expression ...
Tópico(s): Lipid metabolism and disorders
2010 - Bioscientifica | Reproduction
... Blood Pressure and Salt Homeostasis by EndothelinDonald E. Kohan, Noreen F. Rossi, Edward W. Inscho, and David M. Pollock1 January 2011 | Physiological Reviews, Vol. 91, ...
Tópico(s): High Altitude and Hypoxia
1993 - American Physiological Society | Physiological Reviews
Mark D. Herron, Donald E. Kohan, C. David Hansen,
A 3 Accepted for publication , . 7-year-old man presented with painful oral, nasal, and scalp erosions of 6 months' duration. Within 2 months, he developed lower extremity edema and a mild cough. He then noticed facial fullness and weight gain. Physical examination revealed periorbital edema as well as edema of the lower extremities. Desquamative gingivitis was prominent. Histopathology and immunofluorescence of skin supported the diagnosis of pemphigus vulgaris. Histopathology, immunofluorescence, ...
Tópico(s): Eosinophilic Disorders and Syndromes
2004 - Elsevier BV | Journal of the American Academy of Dermatology
Caitlin Bentley, Christine Aicardi, Sammia Poveda, Leonardo Magela Cunha, David Kohan Marzagão, Richard Glover, Eryn Rigley, Simon Walker, Martin Compton, Oguz A. Acar,
With the emergence of generative AI, and its disruption within education, debates have been preoccupied with technocentric problems and deployment issues. This focus often overshadows the broader questions about crafting a responsible educational vision in an AI-dominated world. While generative AI may offer transformative potential for education, it also comes with challenges, from biases to facilitating academic dishonesty. However, focusing solely on these challenges diverts attention from deeper ...
Tópico(s): Ethics and Social Impacts of AI
2023 - RELX Group (Netherlands) | SSRN Electronic Journal
Kevin M. Kubachka, Michael C. Kohan, Karen Herbin-Davis, John T. Creed, David J. Thomas,
Although metabolism of arsenicals to form methylated oxoarsenical species has been extensively studied, less is known about the formation of thiolated arsenical species that have recently been detected as urinary metabolites. Indeed, their presence suggests that the metabolism of ingested arsenic is more complex than previously thought. Recent reports have shown that thiolated arsenicals can be produced by the anaerobic microflora of the mouse cecum, suggesting that metabolism prior to systemic ...
Tópico(s): Moringa oleifera research and applications
2008 - Elsevier BV | Toxicology and Applied Pharmacology
Tatyana S. Pinyayev, Michael J. Kohan, Karen Herbin-Davis, John T. Creed, David J. Thomas,
The conventional scheme for arsenic methylation accounts for methylated oxyarsenical production but not for thioarsenical formation. Here, we report that in vitro anaerobic microbiota of mouse cecum converts arsenate into oxy- and thio- arsenicals. Besides methylarsonic acid (MMAV), arsenate was transformed into six unique metabolites: mono-, di-, and trithio-arsenic acid, monomethyldithio- and monomethyltrithio-arsonic acid, and dimethyldithioarsonic acid. Thioarsenicals were found in soluble and ...
Tópico(s): Selenium in Biological Systems
2011 - American Chemical Society | Chemical Research in Toxicology