Davide Biondini, Mariaenrica Tinè, Umberto Semenzato, Matteo Daverio, Francesca Scalvenzi, Erica Bazzan, Graziella Turato, Marco Damin, Paolo Spagnolo,
Endobronchial Ultrasound (EBUS) has been widely used to stage lung tumors and to diagnose mediastinal diseases. In the last decade, this procedure has evolved in several technical aspects, with new tools available to optimize tissue sampling and to increase its diagnostic yield, like elastography, different types of needles and, most recently, miniforceps and cryobiopsy. Accordingly, the indications for the use of the EBUS scope into the airways to perform the Endobronchial Ultrasound–TransBronchial ...
Tópico(s): Medical Imaging and Pathology Studies
2023 - Multidisciplinary Digital Publishing Institute | Diagnostics
Davide Biondini, Elisabetta Cocconcelli, Nicol Bernardinello, Giulia Lorenzoni, Chiara Rigobello, Sara Lococo, G. Castelli, Simonetta Baraldo, Manuel G. Cosío, Darío Gregori, Marina Saetta, Elisabetta Balestro, Paolo Spagnolo,
Abstract Background A common variant located in the promoter region of MUC5B (rs35705950) is the strongest risk factor for sporadic and familiar IPF, as well as a predictor of outcome. However, there are no data on the effect of MUC5B rs35705950 genotype on the prognosis of IPF patients on antifibrotic treatment. The aim of this study is to determine, in a phenotypically well-characterized population of patients with IPF treated with antifibrotics, the impact of MUC5B rs35705950 genotype on disease ...
Tópico(s): Cystic Fibrosis Research Advances
2021 - BioMed Central | Respiratory Research
Erica Bazzan, Mariaenrica Tinè, Alvise Casara, Davide Biondini, Umberto Semenzato, Elisabetta Cocconcelli, Elisabetta Balestro, Marco Damin, Claudia Maria Radu, Graziella Turato, Simonetta Baraldo, Paolo Simioni, Paolo Spagnolo, Marina Saetta, Manuel G. Cosío,
Extracellular vesicles (EVs) are a family of particles/vesicles present in blood and body fluids, composed of phospholipid bilayers that carry a variety of molecules that can mediate cell communication, modulating crucial cell processes such as homeostasis, induction/dampening of inflammation, and promotion of repair. Their existence, initially suspected in 1946 and confirmed in 1967, spurred a sharp increase in the number of scientific publications. Paradoxically, the increasing interest for EV ...
Tópico(s): MicroRNA in disease regulation
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Davide Biondini, Elisabetta Balestro, Nicola Sverzellati, Elisabetta Cocconcelli, Nicol Bernardinello, Christopher J. Ryerson, Paolo Spagnolo,
Introduction: Idiopathic pulmonary fibrosis (IPF), the most common of the idiopathic interstitial pneumonias, is a disease with a poor prognosis, and a highly heterogeneous and unpredictable clinical course. While most patients experience a relatively slow clinical, functional and radiological deterioration, a significant minority develops episodes of acute respiratory worsening termed acute exacerbations of IPF (AE-IPF). AE-IPF cannot be predicted or prevented and precede approximately half of IPF- ...
Tópico(s): Pneumonia and Respiratory Infections
2020 - Taylor & Francis | Expert Review of Respiratory Medicine
Paolo Spagnolo, Elisabetta Balestro, Stefano Aliberti, Elisabetta Cocconcelli, Davide Biondini, Giovanni Della Casa, Nicola Sverzellati, Toby M. Maher,
As of May 6, 2020, nearly 3·7 million people have been infected and around 260 000 people have died from coronavirus disease 2019 (COVID-19) worldwide.1WHOCoronavirus disease 2019 (COVID-19) situation report.https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happenDate: 2020Date accessed: May 6, 2020Google Scholar Almost all COVID-19-related serious consequences feature pneumonia.2Guan WJ Ni ZY Hu Y et al.Clinical characteristics of coronavirus disease 2019 in China.N Engl ...
Tópico(s): COVID-19 and healthcare impacts
2020 - Elsevier BV | The Lancet Respiratory Medicine
Elisabetta Cocconcelli, Davide Biondini, Chiara Giraudo, Sara Lococo, Nicol Bernardinello, Giulia Fichera, Giulio Barbiero, G. Castelli, Silvia Cavinato, Anna Ferrari, Marina Saetta, Anna Maria Cattelan, Paolo Spagnolo, Elisabetta Balestro,
Coronavirus disease 2019 (COVID-19) has rapidly become a global pandemic with lung disease representing the main cause of morbidity and mortality. Conventional chest-X ray (CXR) and ultrasound (US) are valuable instruments to assess the extent of lung involvement. We investigated the relationship between CXR scores on admission and the level of medical care required in patients with COVID-19. Further, we assessed the CXR-US correlation to explore the role of ultrasound in monitoring the course of COVID- ...
Tópico(s): Respiratory Support and Mechanisms
2020 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Erica Bazzan, Claudia Maria Radu, Mariaenrica Tinè, Tommaso Neri, Davide Biondini, Umberto Semenzato, Alvise Casara, Elisabetta Balestro, Paolo Simioni, Alessandro Celi, Manuel G. Cosío, Marina Saetta,
Microvesicles (MVs) released from almost all cells are recognized as cell communication tools. MVs have been investigated in several inflammatory diseases but poorly in biological fluids like bronchoalveolar lavage (BAL) of smokers. The purpose of this study was to investigate the presence and source of MVs in BAL of smokers with and without chronic obstructive pulmonary disease (COPD) compared with nonsmoking controls. Using flow cytometry in BAL, we detected endothelial and alveolar macrophage (AM)- ...
Tópico(s): Viral Infections and Vectors
2020 - American Physical Society | AJP Lung Cellular and Molecular Physiology
Paolo Spagnolo, Philip L. Molyneaux, Nicol Bernardinello, Elisabetta Cocconcelli, Davide Biondini, Federico Fracasso, Mariaenrica Tinè, Marina Saetta, Toby M. Maher, Elisabetta Balestro,
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease that commonly affects older adults and is associated with the histopathological and/or radiological patterns of usual interstitial pneumonia (UIP). Despite significant advances in our understanding of disease pathobiology and natural history, what causes IPF remains unknown. A potential role for infection in the disease’s pathogenesis and progression or as a trigger of acute exacerbation has long been ...
Tópico(s): Inhalation and Respiratory Drug Delivery
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Elisabetta Balestro, Elisabetta Cocconcelli, Chiara Giraudo, Roberta Polverosi, Davide Biondini, Donato Lacedonia, Erica Bazzan, Linda Mazzai, Giulia Rizzon, Sara Lococo, Graziella Turato, Mariaenrica Tinè, Manuel G. Cosío, Marina Saetta, Paolo Spagnolo,
Antifibrotic treatment slows down functional decline and disease progression in idiopathic pulmonary fibrosis (IPF). High-resolution computed tomography (HRCT) is useful to diagnose IPF; however, little is known about whether and to what extent HRCT changes reflect functional changes during antifibrotic therapy. The aim of this study was, therefore, to assess HRCT change over time after 1 year of treatment and to evaluate whether these changes correlate with functional decline over the same period ...
Tópico(s): Occupational and environmental lung diseases
2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Catharina C. Moor, Marlies Wijsenbeek, Elisabetta Balestro, Davide Biondini, Benjamin Bondue, Vincent Cottin, Ron Flewett, Liam Galvin, Steve Jones, María Molina‐Molina, Lurdes Planas‐Cerezales, Antje Prasse, Helmut Prosch, Anne‐Marie Russell, Michel Viegas, Guenther Wanke, Wim Wuyts, Michael Kreuter, Francesco Bonella,
Introduction Pulmonary fibrosis (PF) and its most common form, idiopathic pulmonary fibrosis (IPF), are chronic, progressive diseases resulting in increasing loss of lung function and impaired quality of life and survival. The aim of this joint expert and patient statement was to highlight the most pressing common unmet needs of patients with PF/IPF, putting forward recommendations to improve the quality of life and health outcomes throughout the patient journey. Methods Two online surveys for patients ...
Tópico(s): Respiratory and Cough-Related Research
2019 - European Respiratory Society | ERJ Open Research
Elisabetta Balestro, Elisabetta Cocconcelli, Mariaenrica Tinè, Davide Biondini, Eleonora Faccioli, Marina Saetta, Federico Rea,
Despite the availability of antifibrotic therapies, many patients with idiopathic pulmonary fibrosis (IPF) will progress to advanced disease and require lung transplantation. International guidelines for transplant referral and listing of patients with interstitial lung disease are not specific to those with IPF and were published before the widespread use of antifibrotic therapy. In this review, we discussed difficulties in decision-making when dealing with patients with IPF due to the wide variability ...
Tópico(s): Polyomavirus and related diseases
2019 - Multidisciplinary Digital Publishing Institute | Medicina
Mariaenrica Tinè, Davide Biondini, Umberto Semenzato, Erica Bazzan, Manuel G. Cosío, Marina Saetta, Graziella Turato,
Blood eosinophils measurement, as proxy for tissue eosinophils, has become an important biomarker for exacerbation risk and response to inhaled corticosteroids (ICS) in Chronic Obstructive Pulmonary Disease (COPD). Its use to determine the pharmacological approach is recommended in the latest COPD guidelines. The potential role of blood eosinophils is mainly based on data derived from post-hoc and retrospective analyses that showed an association between increased blood eosinophils and risk of exacerbations, ...
Tópico(s): Respiratory and Cough-Related Research
2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Elisabetta Cocconcelli, Elisabetta Balestro, Davide Biondini, Giulio Barbiero, Roberta Polverosi, Fiorella Calabrese, Federica Pezzuto, Donato Lacedonia, Federico Rea, Marco Schiavon, Erica Bazzan, Maria Pia Foschino Barbaro, Graziella Turato, Paolo Spagnolo, Manuel G. Cosío, Marina Saetta,
High-Resolution Computed Tomography (HRCT) plays a central role in diagnosing Idiopathic Pulmonary Fibrosis (IPF) while its role in monitoring disease progression is not clearly defined. Given the variable clinical course of the disease, we evaluated whether HRCT abnormalities predict disease behavior and correlate with functional decline in untreated IPF patients. Forty-nine patients (with HRCT1) were functionally categorized as rapid or slow progressors. Twenty-one had a second HRCT2. Thirteen patients ...
Tópico(s): Pleural and Pulmonary Diseases
2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Erica Bazzan, Mariaenrica Tinè, Davide Biondini, Riccardo Benetti, Simonetta Baraldo, Graziella Turato, S. Fagiuoli, Aurelio Sonzogni, Chiara Rigobello, Federico Rea, Fiorella Calabrese, Maria Pia Foschino Barbaro, Elena Miranda, David A. Lomas, Marina Saetta, Manuel G. Cosío,
The deficiency of α1-antitrypsin (AAT) is secondary to misfolding and polymerization of the abnormal Z-AAT in liver cells and is associated with lung emphysema. Alveolar macrophages (AMs) produce AAT; however, it is not known whether Z-AAT can polymerize in AMs, further decreasing lung AAT and promoting lung inflammation. Our intention was to investigate whether AAT polymerizes in human AMs and to study the possible relation between polymerization and degree of lung inflammation.Immunohistochemical ...
Tópico(s): Pulmonary Hypertension Research and Treatments
2018 - Elsevier BV | CHEST Journal
Matteo Bonato, Erica Bazzan, Deborah Snijders, Mariaenrica Tinè, Davide Biondini, Graziella Turato, Elisabetta Balestro, Alberto Papi, Manuel G. Cosío, Angelo Barbato, Simonetta Baraldo, Marina Saetta,
Wheeze is a common symptom in infants, but not all wheezers develop asthma. Indeed, up to 50% of wheezing children outgrow their symptoms by school age. How to predict if early wheeze will become asthma is still a matter of vivid debate. In this work, we sought to assess the clinical and pathological factors that might predict the future development of asthma in children. Eighty children (mean age 3.8 ± 1 yr) who underwent a clinically indicated bronchoscopy were followed prospectively for a median ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2018 - American Thoracic Society | American Journal of Respiratory Cell and Molecular Biology
Klaus F. Rabe, Henrik Watz, Simonetta Baraldo, Frauke Pedersen, Davide Biondini, Nitin Bagul, Guido Hanauer, Udo‐Michael Göhring, Debasree Purkayastha, Jonas Román, Vijay Alagappan, Marina Saetta,
Background The clinical effects of roflumilast, a selective phosphodiesterase-4 inhibitor, are well established, but little is known about the anti-inflammatory mechanisms underlying the drug's efficacy. The aim of the ROflumilast Biopsy European Research Trial (ROBERT) was to assess the anti-inflammatory effects of roflumilast on bronchial mucosal inflammation in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) and chronic bronchitis. Methods ROBERT was a randomised, ...
Tópico(s): Respiratory Support and Mechanisms
2018 - Elsevier BV | The Lancet Respiratory Medicine
Davide Biondini, Elisabetta Balestro, Donato Lacedonia, Stefania Cerri, Rosanna Milaneschi, Fabrizio Luppi, Elisabetta Cocconcelli, Erica Bazzan, Enrico Clini, Maria Pia Foschino Barbaro, Darío Gregori, Manuel G. Cosío, Marina Saetta, Paolo Spagnolo,
Abstract Pirfenidone reduces functional decline in patients with Idiopathic Pulmonary Fibrosis (IPF). However, response to treatment is highly heterogeneous. We sought to evaluate whether response to pirfenidone is influenced by the pretreatment rate of forced vital capacity (FVC) decline. Fifty-six IPF patients were categorized as rapid (RP) or slow progressors (SP) based on whether their FVC decline in the year preceding pirfenidone treatment was > or ≤ 10% predicted. Following pirfenidone treatment patients ...
Tópico(s): Pneumonia and Respiratory Infections
2018 - Nature Portfolio | Scientific Reports
Graziella Turato, Umberto Semenzato, Erica Bazzan, Davide Biondini, Mariaenrica Tinè, Nerea Torrecilla, Marta Forner, José M. Marı́n, Manuel G. Cosío, Marina Saetta,
Tópico(s): Respiratory Support and Mechanisms
2017 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Simonetta Baraldo, Marco Contoli, Matteo Bonato, Deborah Snijders, Davide Biondini, Erica Bazzan, Manuel G. Cosío, Angelo Barbato, Alberto Papi, Marina Saetta,
Tópico(s): Immune Cell Function and Interaction
2017 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Erica Bazzan, Graziella Turato, Mariaenrica Tinè, Claudia Maria Radu, Elisabetta Balestro, Chiara Rigobello, Davide Biondini, Marco Schiavon, Francesca Lunardi, Simonetta Baraldo, Federico Rea, Paolo Simioni, Fiorella Calabrese, Marina Saetta, Manuel G. Cosío,
It is known that tissue macrophages derive not only from blood monocytes but also from yolk sac or fetal liver, and the tissue of residence guides their function. When isolated, they lose tissue specific signatures, hence studies of human macrophages should be ideally done directly in the tissue. The aim of this study was to investigate directly in human lung tissue the polarization of alveolar macrophage (AM), classic (M1) or alternative (M2), in health and disease, using COPD as a model. Surgical ...
Tópico(s): Epigenetics and DNA Methylation
2017 - BioMed Central | Respiratory Research
Elisabetta Balestro, Fiorella Calabrese, Graziella Turato, Francesca Lunardi, Erica Bazzan, Giuseppe Marulli, Davide Biondini, Emanuela Rossi, Alessandro Sanduzzi, Federico Rea, Chiara Rigobello, Darío Gregori, Simonetta Baraldo, Paolo Spagnolo, Manuel G. Cosío, Marina Saetta,
The clinical course in idiopathic pulmonary fibrosis (IPF) is highly heterogeneous, with some patients having a slow progression and others an accelerated clinical and functional decline. This study aims to clinically characterize the type of progression in IPF and to investigate the pathological basis that might account for the observed differences in disease behavior. Clinical and functional data were analyzed in 73 IPF patients, followed long-time as candidates for lung transplantation. The forced ...
Tópico(s): Eosinophilic Disorders and Syndromes
2016 - Public Library of Science | PLoS ONE
B. Renaud-Picard, T. Dégot, Davide Biondini, Noëlle Weingertner, Jérémie Reeb, Marie Pierre Chenard, Romain Kessler,
Acute fibrinous and organizing pneumonia (AFOP) is an unusual histopathologic pattern characterized by the formation of intra-alveolar plugs of fibrin deposition and associated organizing pneumonia. AFOP is considered to be a form of rejection and portends a dismal prognosis. Here, we present the case of a young male patient who initially underwent a double lung transplantation for cystic fibrosis. After 42 months of regular follow-up, he experienced rapidly progressive respiratory failure. Acute ...
Tópico(s): Medical Imaging and Pathology Studies
2015 - Elsevier BV | Transplantation Proceedings
Elisabetta Balestro, G. Castelli, Nicol Bernardinello, Elisabetta Cocconcelli, Davide Biondini, Federico Fracasso, Federico Rea, Marina Saetta, Simonetta Baraldo, Paolo Spagnolo,
Idiopathic pulmonary fibrosis presents a progressive and heterogeneous functional decline. CA 19-9 has been proposed as biomarker to predict disease course, but its role remains unclear. We assessed CA 19-9 levels and clinical data in end-stage ILD patients (48 IPF and 20 non-IPF ILD) evaluated for lung transplant, to correlate these levels with functional decline. Patients were categorized based on their rate of functional decline as slow (n = 20; ΔFVC%pred ≤ 10%/year) or rapid progressors (n = 28; ΔFVC% ...
Tópico(s): Eosinophilic Disorders and Syndromes
2020 - SAGE Publishing | Chronic Respiratory Disease
Mariaenrica Tinè, Erica Bazzan, Umberto Semenzato, Davide Biondini, Elisabetta Cocconcelli, Elisabetta Balestro, Alvise Casara, Simonetta Baraldo, Graziella Turato, Manuel G. Cosío, Marina Saetta,
Background: Some 20% of patients with stable Chronic Obstructive Pulmonary Disease (COPD) might have heart failure (HF). HF contribution to acute exacerbations of COPD (AECOPD) presenting to the emergency department (ED) is not well established. Aims: To assess (1) the HF incidence in patients presenting to the ED with AECOPD; (2) the concordance between ED and respiratory ward (RW) diagnosis; (3) the factors associated with risk of death after hospital discharge. Methods: Retrospective chart review of ...
Tópico(s): Respiratory Support and Mechanisms
2020 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Simonetta Baraldo, Elisabetta Balestro, Erica Bazzan, Maria Enrica Tiné, Davide Biondini, Graziella Turato, Manuel G. Cosío, Marina Saetta,
More than 50 years ago, the observation that absence of the α<sub>1</sub> band from protein electrophoresis is associated with severe emphysema established the link between α<sub>1</sub>-antitrypsin deficiency (AATD) and lung damage. From this discovery, the classic paradigm of protease/antiprotease imbalance was derived, linking lung destruction in patients with AATD to the unopposed effect of proteases. By extension, this paradigm was also applied to patients with ‘common' ...
Tópico(s): Pulmonary Hypertension Research and Treatments
2016 - Karger Publishers | Respiration
Mariaenrica Tinè, Davide Biondini, Marco Damin, Umberto Semenzato, Erica Bazzan, Graziella Turato,
Lung cancer still represents the main cause of cancer death worldwide. The poor survival is mainly related to the diagnosis which is often obtained in advanced stages when the disease is unresectable and characterized by the worst prognosis. Only in the last decades have great discoveries led to the development of new therapies targeted to oncogenes and to boost the host immune response against the tumor. Tumor identification and molecular/immunological characterization rely on bioptic samples which ...
Tópico(s): Pulmonary Hypertension Research and Treatments
2023 - Multidisciplinary Digital Publishing Institute | Biology
Umberto Semenzato, Davide Biondini, Erica Bazzan, Mariaenrica Tinè, Elisabetta Balestro, Barbara Buldini, Santiago J. Carizzo, Pablo Cubero, Marta Marín‐Oto, Alvise Casara, Simonetta Baraldo, Graziella Turato, Darío Gregori, José M. Marı́n, Manuel G. Cosío, Marina Saetta,
Smokers with and without chronic obstructive pulmonary disease (COPD) are at risk of severe outcomes like exacerbations, cancer, respiratory failure, and decreased survival. The mechanisms for these outcomes are unclear; however, there is evidence that blood lymphocytes (BL) number might play a role.The objective of this study is to investigate the relationship between BL and their possible decline over time with long-term outcomes in smokers with and without COPD.In 511 smokers, 302 with COPD (COPD) ...
Tópico(s): Immune Cell Function and Interaction
2021 - Karger Publishers | Respiration
Matteo Bonato, Mariaenrica Tinè, Erica Bazzan, Davide Biondini, Marina Saetta, Simonetta Baraldo,
Asthma is a heterogeneous condition characterized by reversible airflow limitation, with different phenotypes and clinical expressions. Although it is known that asthma is influenced by age, gender, genetic background, and environmental exposure, the natural history of the disease is still incompletely understood. Our current knowledge of the factors determining the evolution from wheezing in early childhood to persistent asthma later in life originates mainly from epidemiological studies. The underlying ...
Tópico(s): Neonatal Respiratory Health Research
2019 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Erica Bazzan, Umberto Semenzato, Graziella Turato, Davide Biondini, Pablo Cubero, Marta Marín‐Oto, Marta Forner, Mariaenrica Tinè, Alvise Casara, Simonetta Baraldo, Paolo Spagnolo, José M. Marı́n, Marina Saetta, Manuel G. Cosío,
COPD is a major health problem, mainly due to cigarette smoking. Most studies in COPD are dedicated to fully developed COPD in older subjects, even though development of COPD may start soon after smoking initiation. Therefore, there is a need to diagnose this "early disease" by detecting the initial events responsible for ultimate development of COPD.Measurement of maximum mid expiratory flow between 25 and 75% of vital capacity (MMEF) in a routine spirometry, which detects small airways disease, ...
Tópico(s): Respiratory Support and Mechanisms
2022 - European Respiratory Society | ERJ Open Research
Sandrine Hirschi, Davide Biondini, Mickaël Ohana, Morgane Solis, Antonio D’Urso, V. Rosner, Romain Kessler,
Abstract Herpes simplex virus ( HSV ) hepatitis is a rare and serious complication in immunocompromised patients. We report the case of an HSV hepatitis occurring 4 years after lung transplantation in a cystic fibrosis patient. The presentation was nonspecific, mimicking acute cholecystitis; orogenital signs were absent. The diagnosis was made based on viral cultures performed during cholecystectomy and confirmed by blood quantitative polymerase chain reaction. Although the diagnosis and treatment were ...
Tópico(s): Polyomavirus and related diseases
2015 - Wiley | Transplant Infectious Disease