Philip Schofield, Barbara Hall, Mike Gerrard, Sir Michael Angus, Richard Ellis, Rob Hughes, John Peter, Andrew Grice Political Correspondent, Mark Reason, Eric Dymock, Fiona Walsh, Susan d'Arcy, Graham Rose, George Macbeth, Diana Wright Personal Finance Editor, Alistair Scott, David Smith, Sean Ryan Environment Correspondent, Bob Holmes, Nick Pitt, A Alvarez, John Rowland, Ludovic Kennedy, Barbara Amlel, Edward Welsh, Richard Guilliatt, Sir Anthony Farrar-Hockley, Geordie Greig, Patrick Stoddart, Robert Sandall, Iain Johnstone, David Brierley, Ivan Fallon, Deryk Brown, Mitchell Platts, Cliff Temple, Lord Harris, Kingsley Amis, Mangal Kapoor, Hugh Canning, Margarette Driscoll, Arabella Fitzmaurice, David Cairns, Peter Kemp, John Melmoth, Fiona Walsh Assistant City Editor, Sean Ryan, Robert Harris, Michael Jones, Liz Hitchcock, Paddy Ashdown, Steve Goldman, War Panel, Fiona Malcolm, John Cassidy, Sue Mott, Robin Marlar, Michael Fishlock Principal, Paul Golding, Bernard Cafferty, Stuart Wavell, Roger Eglin, Jeff Randall, Paul Driver, James Adams, David Hughes, Austin MacCurtain, Tim Rayment, Sophia Sackville-West, Rufus Olins, John Hopkins, Rosemary Stark, Helen Fielding, John Karter, Malcolm Winton, Mark Ollaway, Sue Golden, Diana Wright, Stephen Jones, Ulick O'connor, Harry Mullan, Richard Palmer, Andrew Grice, Irwin Steizer, Keith Wheatley, Ian Birrell, Rodney Pinder, Polly Samson, Callan Pinckney, Ian Glover-James, John A. Hatbaway, Norman Stone, Clive Everton, Edwin Mullins, Richard Woods, Maurice Chittenden, Mitchell Symons, David Hughes Chief Political Correspondent, T A Maher Chairman, Brian MacArthur, Tony Gould, Andrew Yates, David Hunn, James Blitz, Godfrey Smith, Andrew Alderson, Cyndi Stivers, Brian Glanville, Stan Levenson, John Carey, Norman Macrae, Chris Dighton, Peter Guttridge, Deirdre Fernand, Dr Anthony Papagiannis, Tim Hulse, Dr David Hope, Claudia Roden, Andrew Lorenz, Russell Celyn Jones, John Parker, Chris Lightbown, Jeff Randall City Editor, Andrew Davidson, Hugh Pearman, Richard Caseby, Margaret Park, David Smith Economics Editor, Penny Perrick, Tony Hetherington, Anthony Howard, Joanna Simon, Sandra Barwick, Iain Jenkins, Boris Schapiro, Mark Wallington,
... on Sussex The Jolly Farmer The Colony La barbe Knees-up for Thigh Society Dispatches Deirdre Fernand ...
1991 - Gale Group | Sunday Times HA GDA
Laurent Pierot, Coralie Barbe, Huu An Nguyen, Denis Herbreteau, Jean‐Yves Gauvrit, Anne-Christine Januel, Fouzi Bala, Pierre‐Olivier Comby, Hubert Desal, Stéphane Velasco, Mohamed Aggour, Emmanuel Chabert, Jacques Sédat, D. Trystram, Gaultier Marnat, Sophie Gallas, Georges Rodesch, Frédéric Clarençon, Sébastien Soize, Matthias Gawlitza, Laurent Spelle, Philip J. White,
... Treatment of Intracranial Aneurysm (ARETA) StudyLaurent Pierot, Coralie Barbe, Huu An Nguyen, Denis Herbreteau, Jean-Yves Gauvrit, Anne-Christine Januel, Fouzi ... Matthias Gawlitza, Laurent Spelle, Philip WhiteLaurent Pierot, Coralie Barbe, Huu An Nguyen, Denis Herbreteau, Jean-Yves Gauvrit, Anne-Christine Januel, Fouzi ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2020 - Radiological Society of North America | Radiology
Gerald Mere, Ernest Newman, John Rothenstein, Ashley Sampson, Charles H. Lomax, Occasional Reader, Sydenham, Hugh Walpole, Henry Longhurst, H. Malcolm McKee, E. N., G. E. D., Yarborough, Sholto Watt, Norman Oliver, Ralph Straus, A. H. Coltart, J. D. Robb, G. I. M. Knight, J. C. Squire, J. M. Bulloch, Mark Kerr, G. C. B. Poulter, John Ollis Pelton, Bernard Shaw, E. V. Lucas, Laurie Magnus, James Agate, Frank Rutter, F. R. Wilson, Stephen Gaselee, B. J. de C. Andrade, William R. Power, G. W. Bishop, R. S., Malcolm Burr, Walter Crick, J. L. Nalmaster, Sydney W. Carroll, D. R. Gent, W. Gordon Grifftths, Godfrey H. Hamilton, J. F. Walmsley, H. C. Minchin, O. R. Fright, R. A. Scott-James, "Atticus", Constance R. Long, R. McNair Scott, W. Addison, Dilys Powell, J. M. B., Katherine A. McElroy, W. H. Chesson, G. E. Harding, Henry S. Salt, T. Earle Welby, Hamilton Price, Troytown, Leonard J. Hodson, R. J. Barrett Financial Editor, H. M. Morris,
... Forests of Kenya and Nigeria." By Richard St. Barbe Baker. (Allen and Unwin. 12s. 6d.) From Castle ...
1932 - Gale Group | Sunday Times HA GDA
P. Dumas, J. P. Dubarry-Barbe, Denis Rivière, Yves Lévy, J. Corset,
Résume : Les paramètres cinétiques, ainsi que l'épaisseur limite de l'alumine formée par oxydation de 1'aluminium, à température et à pression ambiantes, ont été déterminées par la technique de réflexion totale atténuée.Le film d'oxyde croît rapidement et atteint une épaisseur limite de 32 S après 10minutes d'exposition à l'air.Des temps d'exposition ultérieurs n'entrainent qu'une faible augmentation de l'épaisseur de l'alumine (environ 40 Â après trois mois d'exposition).Une étude par spectroscopie ...
Tópico(s): Semiconductor materials and devices
1983 - EDP Sciences | Le Journal de Physique Colloques
Mélanie Blasi, Jean‐Christophe Barbe, Denis Dubourdieu, Hervé Deleuze,
Sulfur dioxide is now considered to be a toxic chemical by most world health authorities. However, it remains an irreplaceable additive in enology for wine conservation, combining antioxidant and antibacterial properties. Sweet white wines from botrytized grapes retain particularly high SO2 levels due to their high sulfur dioxide binding power. This paper presents a new method for reducing this binding power by removing some of the carbonyl compounds responsible, which are naturally present in these ...
Tópico(s): Advanced Chemical Sensor Technologies
2008 - American Chemical Society | Journal of Agricultural and Food Chemistry
Xavier Leleu, Lionel Karlin, Margaret Macro, Cyrille Hulin, Laurent Garderet, Murielle Roussel, Bertrand Arnulf, Brigitte Pegourié, Brigitte Kolb, Anne Marie Stoppa, Sabine Brechiniac, Gérald Marit, Béatrice Thielemans, Brigitte Onraed, Claire Mathiot, Anne Banos, Laurence Lacotte, Mourad Tiab, Mamoun Dib, Jean‐Gabriel Fuzibet, Marie Odile Petillon, Philippe Rodon, Marc Wetterwald, Bruno Royer, Laurence Legros, Lotfi Benboubker, Olivier Decaux, Martine Escoffre‐Barbe, Denis Caillot, Jean Paul Fermand, Philippe Moreau, Michel Attal, Hervé Avet‐Loiseau, Thierry Façon,
Key Points Pom-Dex is active and well tolerated in adverse cytogenetic patients with early RRMM, particularly in those with del(17p). Pom-Dex prolonged OS in adverse cytogenetic patients with early RRMM.
Tópico(s): Peptidase Inhibition and Analysis
2015 - Elsevier BV | Blood
Arnaud Pigneux, Marie C. Béné, Philippe Guardiola, Christian Récher, Jean‐François Hamel, Mathieu Sauvezie, Jean‐Luc Harousseau, Olivier Tournilhac, Francis Witz, Christian Berthou, Martine Escoffre‐Barbe, Denis Guyotat, Nathalie Fegueux, Chantal Himberlin, Mathilde Hunault, Martine Delain, Bruno Lioure, Éric Jourdan, Frédéric Bauduer, F. Dreyfus, Jean‐Yves Cahn, Jean‐Jacques Sotto, Norbert Ifrah,
Purpose Elderly patients with acute myeloid leukemia (AML) have a poor prognosis, and innovative maintenance therapy could improve their outcomes. Androgens, used in the treatment of aplastic anemia, have been reported to block proliferation of and initiate differentiation in AML cells. We report the results of a multicenter, phase III, randomized open-label trial exploring the benefit of adding androgens to maintenance therapy in patients 60 years of age or older. Patients and Methods A total of ...
Tópico(s): Multiple Myeloma Research and Treatments
2016 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Christine Barbe, Denis Dubourdieu,
Pectolytic enzymatic preparations used in enology come from Aspergillus niger. They have a desirable principal activity and several secondary activities. Among these secondary activities, three classes of esterases were detected: an esterase specific for ester linkage between cinnamic acid and alcohol (cinnamate esterase); an esterase acting on ester linkage between two phenolic rings (depsidase); and an esterase hydrolysing ester linkage between phenolic acids and straight-chain alcohols (phenyl esterase). ...
Tópico(s): Fermentation and Sensory Analysis
1998 - Wiley | Journal of the Science of Food and Agriculture
Laurent Pierot, Coralie Barbe, Denis Herbreteau, Jean‐Yves Gauvrit, Anne-Christine Januel, Fouzi Bala, F. Ricolfi, Hubert Desal, Stéphane Velasco, Mohamed Aggour, Emmanuel Chabert, Jacques Sédat, D. Trystram, Gaultier Marnat, Sophie Gallas, Georges Rodesch, Frédéric Clarençon, Chrysanthi Papagiannaki, Phil White, Laurent Spelle,
Endovascular treatment is the first line therapy for the management of ruptured and unruptured intracranial aneurysms, but delayed aneurysm rupture leading to bleeding/rebleeding can occur subsequently. ARETA (Analysis of Recanalization after Endovascular Treatment of intracranial Aneurysm) is a prospective, multicenter study conducted to analyze aneurysm recanalization. We analyzed delayed bleeding and rebleeding in this large cohort.16 neurointerventional departments prospectively enrolled patients ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2020 - BMJ | Journal of NeuroInterventional Surgery
Laurent Pierot, Coralie Barbe, Denis Herbreteau, Jean‐Yves Gauvrit, Anne-Christine Januel, Fouzi Bala, F. Ricolfi, Hubert Desal, Stéphane Velasco, Mohamed Aggour, Emmanuel Chabert, Jacques Sédat, D. Trystram, Gaultier Marnat, Sophie Gallas, Georges Rodesch, Frédéric Clarençon, Chrysanthi Papagiannaki, Phil White, Laurent Spelle,
Coiling, including balloon-assisted coiling (BAC), is the first-line therapy for ruptured and unruptured aneurysms. Its efficacy can be clinically evaluated by bleeding/rebleeding rate after coiling, and anatomically evaluated by aneurysm occlusion post-procedure and during follow-up. We aimed to analyze immediate post-coiling aneurysm occlusion and associated factors within the Analysis of Recanalization after Endovascular Treatment of intracranial Aneurysm (ARETA) population.Between December 2013 ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2020 - BMJ | Journal of NeuroInterventional Surgery
Robin Vanstokstraeten, N. Belasri, Thomas Demuyser, Florence Crombé, Kurt Barbé, Denis Piérard,
In our tertiary care center, the reported susceptibility of E. coli blood isolates to amoxicillin/clavulanic acid exceeded 90% in 2005 and showed a progressive decrease to 50% by 2017. In this study, we investigate whether there is a real increase in resistant E. coli strains or if this apparent decline in reported susceptibility might be attributed to the substitution of CLSI by EUCAST guidelines in 2014. We randomly selected 237 E. coli blood isolates (stored at − 80 °C) from 1985 to 2018 and reassessed ...
Tópico(s): Enterobacteriaceae and Cronobacter Research
2021 - Springer Science+Business Media | European Journal of Clinical Microbiology & Infectious Diseases
Laurent Pierot, Coralie Barbe, Denis Herbreteau, Jean‐Yves Gauvrit, Anne-Christine Januel, Fouzi Bala, F. Ricolfi, Hubert Desal, Stéphane Velasco, Mohamed Aggour, Emmanuel Chabert, Jacques Sédat, D. Trystram, Gaultier Marnat, Sophie Gallas, Georges Rodesch, Frédéric Clarençon, Chrysanthi Papagiannaki, Phil White, Laurent Spelle,
Background Coiling is the first-line treatment for the management of unruptured intracranial aneurysms (UIAs), but delayed thromboembolic events (TEEs) can occur after such treatment. ARETA (Analysis of Recanalization after Endovascular Treatment of Intracranial Aneurysm) is a prospective multicenter study conducted to analyze aneurysm recanalization. We analyzed delayed TEEs in the UIA subgroup. Methods Sixteen neurointerventional departments prospectively enrolled patients treated for ruptured and ...
Tópico(s): Vascular Malformations Diagnosis and Treatment
2020 - BMJ | Journal of NeuroInterventional Surgery
Núria Fonknechten, Sébastien Chaussonnerie, Sabine Tricot, Aurélie Lajus, Jan R. Andreesen, Nadia Perchat, Éric Pelletier, Michel Gouyvenoux, Valérie Barbe, Marcel Salanoubat, Denis Le Paslier, Jean Weissenbach, Georges N. Cohen, Annett Kreimeyer,
Abstract Background Clostridium sticklandii belongs to a cluster of non-pathogenic proteolytic clostridia which utilize amino acids as carbon and energy sources. Isolated by T.C. Stadtman in 1954, it has been generally regarded as a "gold mine" for novel biochemical reactions and is used as a model organism for studying metabolic aspects such as the Stickland reaction, coenzyme-B12- and selenium-dependent reactions of amino acids. With the goal of revisiting its carbon, nitrogen, and energy metabolism, ...
Tópico(s): Metabolism and Genetic Disorders
2010 - BioMed Central | BMC Genomics
Mélanie Blasi, Jean‐Christophe Barbe, Bernard Maillard, Denis Dubourdieu, Hervé Deleuze,
Sweet white wines from botrytized grapes present high SO2 levels because of their high sulfur dioxide binding power. The objective of this work was to develop a new method for reducing this binding power by partially eliminating the carbonyl compounds naturally present in these wines that are responsible for this phenomenon. A selective liquid–solid removal technique was developed. Phenylsulfonylhydrazine was selected as the best candidate for removing carbonyl compounds. Its reactivity in the presence ...
Tópico(s): Polyamine Metabolism and Applications
2007 - American Chemical Society | Journal of Agricultural and Food Chemistry
Xavier Leleu, Michel Attal, Bertrand Arnulf, Philippe Moreau, Catherine Traullé, Gérald Marit, Claire Mathiot, Marie Odile Petillon, Margaret Macro, Murielle Roussel, Brigitte Pegourié, Brigitte Kolb, Anne Marie Stoppa, Bernadette Hennache, Sabine Bréchignac, Nathalie Meuleman, Béatrice Thielemans, Laurent Garderet, Bruno Royer, Cyrille Hulin, Lotfi Benboubker, Olivier Decaux, Martine Escoffre‐Barbe, Mauricette Michallet, Denis Caillot, Jean Paul Fermand, Hervé Avet‐Loiseau, Thierry Façon,
Key Points Combination of pomalidomide with dexamethasone is highly active and can salvage end stage myeloma refractory to lenalidomide and bortezomib. Current data suggest pomalidomide 4 mg/day on days 1 to 21 per 28-days cycle with dexmethasone should be studied in future phase 3 trials.
Tópico(s): Myeloproliferative Neoplasms: Diagnosis and Treatment
2013 - Elsevier BV | Blood
Bénédicte Pineau, Jean‐Christophe Barbe, Cornelis van Leeuwen, Denis Dubourdieu,
A preparative HPLC method, which preserves wine aromas and isolates fruity characteristics in specific fractions, was applied to red wine aroma extracts. Various odor-active zones were detected in typical fractions by GC-O analysis of their extracts. Through further GC-MS analyses, the aromatic compounds responsible for 15 of these odoriferous zones were identified as various ethyl esters and alkyl acetates. In view of their olfactory thresholds, the concentrations of these compounds had no direct ...
Tópico(s): Phytochemicals and Antioxidant Activities
2009 - American Chemical Society | Journal of Agricultural and Food Chemistry
Bénédicte Pineau, Jean‐Christophe Barbe, Cornelis van Leeuwen, Denis Dubourdieu,
beta-Damascenone, a C-13 norisoprenoid compound, is usually presented as an impact odorant in red wines. Its direct contribution to their aroma was investigated. Both free beta-damascenone and beta-damascenone precursors were isolated from various French red wines and then analyzed by gas chromatography-mass spectrometry, revealing concentrations in the vicinity of 1 and 2 microg/L for free compounds and both forms, respectively. Gas chromatography-olfactometry analyses were also performed on dilutions ...
Tópico(s): Phytochemicals and Antioxidant Activities
2007 - American Chemical Society | Journal of Agricultural and Food Chemistry
Laurent Pierot, Coralie Barbe, Huu An Nguyen, Denis Herbreteau, Jean‐Yves Gauvrit, Anne-Christine Januel, Fouzi Bala, Pierre‐Olivier Comby, Hubert Desal, Stéphane Velasco, Mohamed Aggour, Emmanuel Chabert, Jacques Sédat, D. Trystram, Gaultier Marnat, Sophie Gallas, Georges Rodesch, Frédéric Clarençon, Sébastien Soize, Matthias Gawlitza, Laurent Spelle, Phil White,
Background Thromboembolic events and intraoperative rupture are the most frequent neurologic complications of intracranial aneurysm coiling. Their frequency has not been evaluated in recent series. Purpose To provide an analysis of complications, clinical outcome, and participant and aneurysm risk factors after aneurysm coiling or balloon-assisted coiling within the Analysis of Recanalization after Endovascular Treatment of Intracranial Aneurysm, or ARETA, cohort. Materials and Methods Sixteen neurointerventional ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2020 - Radiological Society of North America | Radiology
Eve Orlandi‐Pradines, Lionel Alméras, Laurent Denis, Solenne Barbe, Franck Remoué, Claude Villard, Sylvie Cornélie, Kristell Penhoat, Aurélie Pascual, Catherine Bourgouin, Didier Fontenille, Julien Bonnet, Nicole Corre-Catelin, Paul L. Reiter, Frédéric Pagès, Daniel Laffite, Denis Boulanger, François Simondon, Bruno Pradines, Thierry Fusaı̈, Christophe Rogier,
Exposure to vectors of infectious diseases has been associated with antibody responses against salivary antigens of arthropods among people living in endemic areas. This immune response has been proposed as a surrogate marker of exposure to vectors appropriate for evaluating the protective efficacy of antivectorial devices. The existence and potential use of such antibody responses in travellers transiently exposed to Plasmodium or arbovirus vectors in tropical areas has never been investigated. ...
Tópico(s): Vector-Borne Animal Diseases
2007 - Elsevier BV | Microbes and Infection
Thierry Barbé, J Losay, Gilles Grimon, Denis Devictor, A Sardet, Frédéric Gauthier, D Houssin, Olivier Bernard,
Abstract Pulmonary arteriovenous shunting (PAVS) with hypoxemia is a severe complication of cirrhosis that may regress after liver transplantation. We report PAVS in 25 children with cirrhosis and in 1 with portal vein obstruction; proof of shunting was obtained by technetium Tc 99m microaggregated albumin pulmonary scanning or a high alveoloarterial O 2 gradient or both. Cyanosis or dyspnea or both occurred at ages ranging from 6 months to 14 years, earlier in children with biliary atresia and polysplenia ...
Tópico(s): Liver Disease Diagnosis and Treatment
1995 - Elsevier BV | The Journal of Pediatrics
Murielle Roussel, Valérie Lauwers‐Cancès, Soraya Wuillème, Karim Belhadj, Salomon Manier, Laurent Garderet, Martine Escoffre‐Barbe, Clara Mariette, Lotfi Benboubker, Denis Caillot, Cécile Sonntag, Cyrille Touzeau, Jehan Dupuis, Philippe Moreau, Xavier Leleu, Thierry Façon, Benjamin Hébraud, Jill Corre, Michel Attal,
Abstract Bortezomib, lenalidomide, and dexamethasone plus transplant is a standard of care for eligible patients with multiple myeloma. Because responses can deepen with time, regimens with longer and more potent induction/consolidation phases are needed. In this phase 2 study, patients received eight 28-day cycles of carfilzomib (K) 20/36 mg/m2 (days 1-2, 8-9, 15-16), lenalidomide (R) 25 mg (days 1–21), and dexamethasone (d) 20 mg (days 1-2, 8-9, 15-16, 22-23). All patients proceeded to transplant after ...
Tópico(s): Peptidase Inhibition and Analysis
2021 - Elsevier BV | Blood
Bénédicte Pineau, Jean‐Christophe Barbe, Cornelis van Leeuwen, Denis Dubourdieu,
<p style="text-align: justify;"><strong>Aims</strong>: The first aim of this investigation was to determine whether red- and black-berry fruit aromas were specific to red wines. The second aim was to study their contribution to the red Bordeaux wine concept.</p><p style="text-align: justify;"><strong>Methods and results</strong>: In experiment 1, red wines were presented to expert assessors in dark, then in clear glasses. Assessors selected wines where they ...
Tópico(s): Fermentation and Sensory Analysis
2010 - ADERA | OENO One
Arnaud Pigneux, Chantal Himberlin, Mathilde Hunault, Francis Witz, Christian Récher, Jean‐Luc Harousseau, Olivier Tournilhac, Christian Berthou, Martine Escoffre‐Barbe, Denis Guyotat, Nathalie Fegueux, Martine Delain, Bruno Lioure, Éric Jourdan, Didier Bouscary, Laurence Legros, Nöel Milpied, Frédéric Bauduer, Frédéric Perry, Isabelle Luquet, Marie C. Béné, Norbert Ifrah, Jean‐Jacques Sotto, Philippe Guardiola,
Abstract The French group, GOELAMS, performed a multicenter phase III randomized open trial to evaluate whether adding androgens to post-remission induction therapy was associated with an improved outcome in elderly pts with de novo AML. All patients received the ICL induction protocol (idarubicin 8mg/m2 day1–5, cytarabine 100mg/m2 day1–7 & lomustine 200mg/m2 day1). Patients in complete or partial remission received maintenance therapy consisting in 6 reinduction courses (idarubicin 8mg/m2 day1, cytarabine ...
Tópico(s): Multiple Myeloma Research and Treatments
2008 - Elsevier BV | Blood
Bénédicte Pineau, Jean‐Christophe Barbe, Cornelis van Leeuwen, Denis Dubourdieu,
<p style="text-align: justify;"><strong>Aim</strong>: The aim of this study was to elucidate how an initially neutral Merlot must resulted in a wine with characteristic aromas of red- and black-berry fruit, focusing on the respective contributions of yeast metabolism together with grape juice, pulp, and skins.</p><p style="text-align: justify;"><strong>Methods and Results</strong>: Sensory analyses were performed on Merlot grape skin maceration models, based ...
Tópico(s): Phytochemicals and Antioxidant Activities
2011 - ADERA | OENO One
Xavier Leleu, Michel Attal, Bertrand Arnulf, Philippe Moreau, Catherine Traullé, Mauricette Michalet, Gérald Marit, Claire Mathiot, Marie Odile Petillon, Margaret Macro, Murielle Roussel, Brigitte Pegourié, Brigitte Kolb, Anne‐Marie Stoppa, Sabine Brechiniac, Laurent Garderet, Bruno Royer, Cyrille Hulin, Lotfi Benboubker, Olivier Decaux, Denis Caillot, Martine Escoffre‐Barbe, Jean Paul Fermand, Hervé Avet‐Loiseau, Thierry Façon,
Abstract Abstract 812FN2 On behalf of IFM (Intergroupe Francophone du Myélome) Background. The interim analysis of this phase 2 randomized open label trial was presented at ASH last year. It aimed to determine the impact of the combination of pomalidomide (oral 4 mg daily) and dexamethasone (oral 40 mg weekly) in pts characterized with advanced myeloma (MM) following lenalidomide and bortezomib. The response rate (ORR, PR and better), and the median PFS were similar in the 2 arms, pomalidomide on days ...
Tópico(s): Acute Myeloid Leukemia Research
2011 - Elsevier BV | Blood
Philippe Moreau, Michel Attal, Lionel Karlin, Laurent Garderet, Thierry Façon, Lotfi Benboubker, Margaret Macro, Denis Caillot, Martine Escoffre‐Barbe, Anne‐Marie Stoppa, Kamel Laribi, Cyrille Hulin, Gérald Marit, Jean-Richard Eveillard, Florence Caillon, Caroline bodet-Millin, Jean‐Michel Nguyen, Brigitte Pegourié, Véronique Dorvaux, Carine Chaleteix, B. Dupas, Françoise Kraeber‐Bodéré,
Abstract Introduction Magnetic resonance imaging (MRI) of the spine and the pelvis is an important tool to evaluate bone disease in patients with symptomatic multiple myeloma (MM) at the time of diagnosis. In the context of high-dose therapy and autologous stem cell transplantation (ASCT), it has also been reported that the number of MRI focal lesions (> 7) and the presence of diffuse pattern correlate with inferior survival (Walker et al. J Clin Oncol; 25:1121-1128 2007). MRI might help in the better ...
Tópico(s): Cancer Treatment and Pharmacology
2014 - Elsevier BV | Blood
Xavier Leleu, Lionel Karlin, Margaret Macro, Cyrille Hulin, Laurent Garderet, Murielle Roussel, Bertrand Arnulf, Brigitte Pegourié, Brigitte Kolb, Anne‐Marie Stoppa, Sabine Brechiniac, Mauricette Michallet, Gérald Marit, Claire Mathiot, Anne Banos, Laurence Lacotte, Mourad Tiab, Mamoun Dib, Jean‐Gabriel Fuzibet, Marie-Odile Pétillon, Philippe Rodon, Marc Wetterwald, Bruno Royer, Laurence Legros, Lotfi Benboubker, Olivier Decaux, Denis Caillot, Martine Escoffre‐Barbe, Jean Paul Fermand, Philippe Moreau, Michel Attal, Hervé Avet‐Loiseau, Thierry Façon,
Abstract Background Multiple myeloma with del(17p) and/or t(4;14) are characterized with short survival related to early relapse rate (median TTP <4 months) and rapid development of mechanisms of resistance to multiple agents. Furthermore, RRMM to IMiDs® imunomodulatory agent and proteasome inhibitors (bortezomib) also display a shortened median survival of approximately 9 months. We and others have previously showed that pomalidomide plus low-dose dexamethasone has produced 30% to 40% response rate ( ...
Tópico(s): Peptidase Inhibition and Analysis
2013 - Elsevier BV | Blood
Michel Attal, Paul G. Richardson, S. Vincent Rajkumar, Jesús F. San Miguel, Meral Beksaç, Ivan Špıčka, Xavier Leleu, Fredrik Schjesvold, Philippe Moreau, Meletios Α. Dimopoulos, Jeffrey Shang-Yi Huang, Jiří Minařík, Michèle Cavo, H. Miles Prince, Sandrine Macé, Kathryn P. Corzo, Frank Campana, Solenn Le-Guennec, Franck Dubin, Kenneth C. Anderson, Michel Attal, Paul G. Richardson, S. Vincent Rajkumar, Jesús F. San Miguel, Meral Beksaç, Ivan Špıčka, Xavier Leleu, Fredrik Schjesvold, Philippe Moreau, Meletios Α. Dimopoulos, Jeffrey Shang-Yi Huang, Jiří Minařík, Michèle Cavo, H. Miles Prince, Sandrine Macé, Kathryn P. Corzo, Frank Campana, Solenn Le-Guennec, Franck Dubin, Kenneth C. Anderson, Simon J. Harrison, Wojt Janowski, Ian Kerridge, Andrew Spencer, Michel Delforge, Karel Fostier, Philip Vlummens, Ka Lung Wu, Richard LeBlanc, Michel Pavic, Michaël Sébag, Roman Hájek, Vladimír Maisnar, Luděk Pour, Henrik Gregersen, Lotfi Benbouker, Denis Caillot, Martine Escoffre‐Barbe, Thierry Façon, Laurent Frenzel, Cyrille Hulin, Lionel Karlin, Brigitte Kolb, Brigitte Pegourié, Aurore Perrot, Mourad Tiab, Laure Vincent, Dietger Niederwieser, Αchilles Anagnostopoulos, Sosana Delimpasi, Marie‐Christine Kyrtsonis, Argiris Symeonidis, Árpád Illés, Gábor Mikala, Zsolt Nagy, Sara Bringen, Paolo Corradini, Fabio Ciceri, Roberto M. Lemoli, Anna Marina Liberati, Chiara Nozzoli, Renato Zambello, Shinsuke Iida, Takashi Ikeda, Satoshi Iyama, Morio Matsumoto, Chihiro Shimazaki, Kazutaka Sunami, Kenshi Suzuki, Michihiro Uchiyama, Youngil Koh, Kihyun Kım, Jae Hoon Lee, Chang‐Ki Min, Hillary Blacklock, Hugh J. B. Goodman, Annette Neylon, David Simpson, Sebastian Grosicki, Artur Jurczyszyn, Adam Walter‐Croneck, Krzysztof Warzocha, Luís Francisco Araújo, Cláudia Moreira, Vadim Doronin, Л. П. Менделеева, Vladimir Vorobyev, Andrej Vranovský, Adrián Alegre, Mercedes Gironella, Marta Sonia González, Carmen Montes, Enrique M. Ocio, Paula Rodríguez, Mats Hardling, Birgitta Lauri, Ming‐Chung Wang, Su‐Peng Yeh, Mutlu Arat, Fatih Demırkan, Zafer Gülbaş, Sevgi Kalayoğlu Beşışık, Ìhsan Karadoǧan, Tülin Tuğlular, Ali Ünal, Filiz Vural, Jonathan Sive, Matthew Streetly, Kwee Yong, Jason Tache,
Isatuximab is a monoclonal antibody that binds a specific epitope on the human CD38 receptor and has antitumour activity via multiple mechanisms of action. In a previous phase 1b study, around 65% of patients with relapsed and refractory multiple myeloma achieved an overall response with a combination of isatuximab with pomalidomide and low-dose dexamethasone. The aim of this study was to determine the progression-free survival benefit of isatuximab plus pomalidomide and dexamethasone compared with ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2019 - Elsevier BV | The Lancet
Xavier Leleu, Michel Attal, Philippe Moreau, Alain Duhamel, Jean Paul Fermand, Mauricette Michalet, Catherine Traullé, Gérald Marit, Murielle Roussel, Brigitte Kolb, Bertrand Arnulf, Laurent Garderet, Claire Mathiot, Margaret Macro, Marie Odile Petillon, Brigitte Pegourié, Anne Marie Stoppa, Sabine Brechiniac, Bruno Royer, Lotfi Benboubker, Denis Caillot, Martine Escoffre‐Barbe, Cyrille Hulin, Jean‐Luc Harousseau, Hervé Avet‐Loiseau, Thierry Façon,
Tópico(s): HIV/AIDS drug development and treatment
2010 - Elsevier BV | Blood
Laura Droctové, Justyna Ciolek, Christiane Mendre, Amélia Chorfa, Paola Huerta, Chrystelle Carvalho, Charlotte Gouin, Manon Lancien, Goran Stanajic‐Petrovic, Lorine Braco, Guillaume Blanchet, Grégory Upert, Gregory De Pauw, Peggy Barbe, Mathilde Keck, Gilles Mourier, Bernard Mouillac, Denis Servent, Ricardo C. Rodrı́guez de la Vega, Loïc Quinton, Nicolas Gilles,
Background and Purpose Venomous animals express numerous Kunitz‐type peptides. The mambaquaretin‐1 (MQ1) peptide identified from the Dendroaspis angusticeps venom is the most selective antagonist of the arginine‐vasopressin V2 receptor (V2R) and the only unique Kunitz‐type peptide active on a GPCR. We aimed to exploit other mamba venoms to enlarge the V2R‐Kunitz peptide family and gain insight into the MQ1 molecular mode of action. Experimental Approach We used a bio‐guided screening assay to identify ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2022 - Wiley | British Journal of Pharmacology