Jiajun Xu, Mahmut Yıldıztekin, Dayong Han, Cumali Keskin, Ayşe Baran, Mehmet Fırat Baran, Aziz Eftekhari, Canan Aytuğ Ava, Sevgi İrtegün Kandemir, Deniz Barış Cebe, Beşir Dağ, Aferin Beilerli, Rovshan Khalilov,
Metallic nanoparticle biosynthesis is thought to offer opportunities for a wide range of biological uses. The green process of turning biological waste into utilizable products gaining attention due to its economical and eco-friendly approach in recent years. This study reported the ability of Solanum tuberosum (ST) peel extract to the green synthesis of non-toxic, stable, small-sized silver nanoparticles without any toxic reducing agent utilizing the phytochemical components present in its structure. ...
Tópico(s): Nanoparticles: synthesis and applications
2023 - Elsevier BV | Heliyon
Baris Deniz, Apoorva Ambavane, Shuo Yang, Arman Altincatal, Justin Doan, Sumati Rao, M. Dror Michaelson,
Objective Advanced renal cell carcinoma (RCC) is commonly treated with vascular endothelial growth factor or mammalian target of rapamycin inhibitors. As new therapies emerge, interest grows in gaining a deeper understanding of treatment sequences. Recently, we developed a patient-level, discretely integrated condition event (DICE) simulation to estimate survival and lifetime costs for various cancer therapies, using a US payer perspective. Using this model, we explored the impact of treatments such ...
Tópico(s): Renal and related cancers
2019 - Public Library of Science | PLoS ONE
Wenqing Su, M. Feldman, Colin Vicente, Baris Deniz, Sujata P. Sarda,
Multiple sclerosis (MS) causes significant disability and diminished quality-of-life. Delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) is a new oral treatment for relapsing-remitting MS (RRMS) approved in the US, Australia, Canada, and Europe.A cost-effectiveness model was developed to compare the health economic impact of DMF against other disease-modifying therapies (DMTs) as first-line RRMS treatment from a Canadian Ministry of Health perspective.A Markov cohort model was ...
Tópico(s): Polyomavirus and related diseases
2016 - Informa | Journal of Medical Economics
Anita J. Brogan, Sandra E. Talbird, James R. Thompson, Jeffrey D. Miller, Jaime Rubin, Baris Deniz,
Objective To explore the expected long-term health and economic outcomes of telaprevir (TVR) plus peginterferon alfa-2a and ribavirin (PR), a regimen that demonstrated substantially increased sustained virologic response (SVR) compared with PR alone in adults with chronic genotype 1 hepatitis C virus (HCV) and compensated liver disease in the Phase III studies ADVANCE (treatment-naïve patients) and REALIZE (relapsers, partial responders, and null responders to previous PR treatment). Study Design A decision- ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2014 - Public Library of Science | PLoS ONE
Michael Hutchinson, Robert J. Fox, Eva Havrdová, Nuwan Kurukulasuriya, Sujata P. Sarda, Sonalee Agarwal, Mohd Kashif Siddiqui, Ankush Taneja, Baris Deniz,
Currently, direct comparative evidence or head-to-head data between BG-12 (dimethyl fumarate) and other disease-modifying treatments (DMTs) is limited. This study is a systematic review and data synthesis of published randomized clinical trials comparing the efficacy and safety of existing DMTs to BG-12 for relapsing-remitting multiple sclerosis (RRMS).A systematic review was conducted by searching MEDLINE, EMBASE, and the Cochrane Library for English-language publications from 1 January 1960 to 15 ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2013 - Taylor & Francis | Current Medical Research and Opinion
M. Michele Manos, Jeanne Darbinian, Jaime Rubin, G. Thomas Ray, Valentina Shvachko, Baris Deniz, Fulton Velez, Charles P. Quesenberry,
Studies suggest that chronic hepatitis C patients who achieve sustained virologic response (SVR) have lower risks of liver-related morbidity and mortality. Given the substantial costs and complexity of hepatitis C virus (HCV) antiviral treatment, post-treatment benefits are important to understand. To determine whether health care costs and utilization for up to 5 years after treatment differed between patients who achieved SVR and those who did not. Kaiser Permanente Medical Care Program patients ...
Tópico(s): Liver Disease and Transplantation
2013 - Academy of Managed Care Pharmacy | Journal of Managed Care Pharmacy
Krzysztof A. Tomaszewski, Baris Deniz, Peter Tomanovich, Camilla S. Graham,
We compared the theoretical performance of a 1-time, birth cohort strategy with the currently recommended risk strategy for screening for hepatitis C virus (HCV) infection, which is undetected in an estimated 75% of 4 million affected people in the United States.We applied current American Association for the Study of Liver Disease risk screening guidelines and a targeted birth cohort strategy to National Health and Nutrition Examination Survey data from 2003 to 2006 to estimate their performance ...
Tópico(s): Hepatitis B Virus Studies
2012 - American Public Health Association | American Journal of Public Health
Joseph Menzin, Leigh Ann White, Christine Nichols, Baris Deniz,
Chronic hepatitis C virus (HCV) may progress to advanced liver disease (ALD), including decompensated cirrhosis and/or hepatocellular carcinoma (HCC). ALD can lead to significant clinical and economic consequences, including liver transplantation. This study evaluated the health care costs associated with ALD among HCV infected patients in a Medicaid population. Using Florida Medicaid claims data, cases were patients with at least 1 diagnosis of HCV or prescription therapy for HCV (ribavirin plus interferon, ...
Tópico(s): Liver Disease Diagnosis and Treatment
2012 - BioMed Central | BMC Health Services Research
Carrie McAdam‐Marx, Lisa J. McGarry, Christopher A. Hane, Joseph Biskupiak, Baris Deniz, Diana Brixner,
BACKGROUND: Approximately 3.2-3.9 million U.S. residents are infected with the hepatitis C virus (HCV). Total annual costs (direct and indirect) in the United States for HCV were estimated to be $5.46 billion in 1997, and direct medical costs have been predicted to increase to $10.7 billion for the 10-year period from 2010 through 2019, due in part to the increasing number of HCV patients developing advanced liver disease (AdvLD). OBJECTIVE: To quantify in a sample of commercially insured enrollees (a) ...
Tópico(s): Liver Disease Diagnosis and Treatment
2011 - Academy of Managed Care Pharmacy | Journal of Managed Care Pharmacy
A. Murat Tuncer, INCI GÜR, Ulya Ertem, Aydın Ece, SAMI TÜRKMEN, Baris Deniz, ISIN GÜRMAN, Safiye Tuncer,
Twenty children with meningococcal disease (15 with meningococcal meningitis and 5 with meningococcemia without meningitis) were treated with ceftriaxone, 80 to 100 mg/kg/day for 4 days. An additional 22 patients with meningococcal disease (13 with meningitis, 9 with meningococcemia without meningitis) were treated with penicillin G. On the basis of the Damrosch-Stiehm scoring system, 19 patients were classified in the poor prognostic group and were treated with antishock therapy. Clinical recovery ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
1988 - Lippincott Williams & Wilkins | The Pediatric Infectious Disease Journal
Ivo Abraham, Uchenna Onyekwere, Baris Deniz, Donald Moran, Marc Chioda, Karen MacDonald, Huan Huang,
Aims Proliferating hematopoietic stem and progenitor cells (HSPCs) are susceptible to chemotherapy-induced damage, resulting in myelosuppressive adverse events (AEs) such as neutropenia, anemia, and thrombocytopenia that are associated with high health care costs and decreased quality of life (QoL). In this study, a trial-based cost-effectiveness analysis was performed to help assess the economic impact of administering trilaciclib, a myeloprotective therapy that protects multilineage HSPCs from chemotherapy- ...
Tópico(s): Cancer therapeutics and mechanisms
2021 - Informa | Journal of Medical Economics
Hafıze Sav, Ayşe Barış, Deniz Turan, Rabiye Altınbaş, Sümeyye Şen,
Although the frequency of candidal onychomycosis is increasing daily, there is little information in literature about the epidemiology, pathogenesis, and antifungal susceptibility of this dermatological disease. This study aimed to provide information about the epidemiology, pathogenesis, and azole susceptibility of Candida species isolated from patients living in a region with continental climate. After identification of the isolated strains using conventional methods, proteinase and phospholipase ...
Tópico(s): Fungal Infections and Studies
2018 - Elsevier BV | Microbial Pathogenesis
Sema Güneri, Nezihi Barış, Deniz Aytekin, Bahri Akdeniz, Nihat Pekel, Volkan Bozdemir,
Patients with diabetes mellitus (DM) have advanced atherosclerosis compared with nondiabetics. Restenosis after intracoronary stent implantation occurs frequently in diabetic patients. Angiotensin II is an important growth factor for the development of neointimal hyperplasia after vascular injury. The aim of our study was to evaluate the relationships between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and coronary artery disease (CAD) and stent restonosis in diabetic ...
Tópico(s): Hormonal Regulation and Hypertension
2005 - Japanese Heart Journal Assoc | International Heart Journal
Ivo Abraham, Amit Goyal, Baris Deniz, Donald Moran, Marc Chioda, Karen MacDonald, Huan Huang,
BACKGROUND: Chemotherapy-induced myelosuppression, which commonly manifests as neutropenia, anemia, and/or thrombocytopenia, is a frequent and severe complication of standard treatment regimens for patients with extensive-stage small cell lung cancer (ES-SCLC). Trilaciclib is a first-in-class myeloprotective therapy indicated to decrease the incidence of chemotherapy-induced myelosuppression when administered prior to a platinum-/etoposide-containing regimen or topotecan-containing regimen for ES- ...
Tópico(s): Neutropenia and Cancer Infections
2022 - AMCP | Journal of Managed Care & Specialty Pharmacy
Baris Deniz, Gareth J. Morgan, Steve Schey, Jack Ishak, Peter Dale, Arran Shearer, José Carlos Espín Jaime,
Tópico(s): Statistical Methods in Clinical Trials
2008 - Elsevier BV | Blood
Baris Deniz, Marı́a Buti, Max Brosa, M.Á. Casado, M. Rueda, F Everhard, Rafael Esteban,
Tópico(s): HIV/AIDS drug development and treatment
2008 - Elsevier BV | Journal of Hepatology
Ahmet Tülek, Elif Günay, Burak Servili, Şebnem Eşsiz, Barış Bi̇nay, Deniz Yıldırım,
Formate dehydrogenase (NAD+-dependent FDH) is an enzyme that catalyzes the reversible oxidation of formate to CO2 while reducing NAD+ to NADH. The enzyme has been used in industrial and chemical applications for NADH regeneration for a long time. However, discovering the unique ability of FDHs, which is to reduce CO2 and produce formic acid, leads studies focusing on discovering or redesigning FDHs. Despite using various protein engineering techniques, these studies mostly target the same catalytic ...
Tópico(s): Catalysis for Biomass Conversion
2023 - Elsevier BV | Separation and Purification Technology
Martin Dyrba, Moritz Hanzig, Slawek Altenstein, Sebastian Bader, Tommaso Ballarini, Frederic Brosseron, Katharina Büerger, Daniel Cantré, Peter Dechent, Laura Dobisch, Emrah Düzel, Michael Ewers, Klaus Fließbach, Wenzel Glanz, John–Dylan Haynes, Michael T. Heneka, Daniel Janowitz, Deniz Baris Keles, Ingo Kilimann, Christoph Laske, Franziska Maier, Coraline D. Metzger, Matthias H. Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris‐Stephan Rauchmann, Nina Roy, Klaus Scheffler, Anja Schneider, Björn H. Schott, Annika Spottke, Eike J. Spruth, Marc‐André Weber, Birgit Ertl‐Wagner, Michael Wagner, Jens Wiltfang, Frank Jessen, Stefan Teipel,
Background: Although convolutional neural networks (CNN) achieve high diagnostic accuracy for detecting Alzheimer's disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap. We investigated whether models with higher accuracy also rely more on discriminative brain regions predefined ...
Tópico(s): Machine Learning in Healthcare
2021 - BioMed Central | Alzheimer s Research & Therapy
Barış Polat, Deniz Aydın, Ayşe Esin Polat, Tahsin Gürpınar, Enes Sarı, Ramadan Özmanevra, Mehmet Yalçınozan, Kaan Erler,
Knee arthroscopy may be called the most commonly and increasingly performed orthopaedic procedure. Posterior medial compartment visualization may be quite challenging. The aim of the present study is to detect objective measurement of medial joint space widening with percutaneous "pie crust" release of medial collateral ligament (MCL) during knee arthroscopy. We used this technique for all knees that require any intervention in the posteromedial compartment and for tight knees in which adequate visualization ...
Tópico(s): Shoulder Injury and Treatment
2019 - Thieme Medical Publishers (Germany) | The Journal of Knee Surgery
Avni İlhan Bayhan, Akay Kırat, Yakup Alpay, Barış Özkul, Deniz Kargın,
Tópico(s): Total Knee Arthroplasty Outcomes
2018 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy
Barış Kuşkonmaz, Deniz Çağdaş, Müge Gökçe, Tuba Turul Özgür, Fatma Visal Okur, Mualla Çetin, İlhan Tezcan, Duygu Uçkan,
GS2 is a rare autosomal recessive disease characterized by hypopigmentation, variable immunodeficiency with HLH. HSCT is the only curative treatment for GS2. We analyzed the outcome of 10 children with GS2 who underwent HSCT at our center between October 1997 and September 2013. The median age of the patients at transplant was 13.5 months (range, 6-58 months). All of the patients developed HLH before HSCT and received HLH 94 or HLH 2004 protocols. Donors were HLA-identical relatives in 8 patients, ...
Tópico(s): Hematopoietic Stem Cell Transplantation
2017 - Wiley | Pediatric Transplantation
Serhat Uzan, Deniz Barış, Mehmet Çolak, Haluk Aydın, Halil Hoşgören,
Aminoalcohol based bis-(aminoalcohol)oxalamides (BAOAs) (1,6-amino alcohol=leucinol, isoleucinol, valinol, phenylglycinol, phenylalaninol and 2-amino-1-butanol) have been explored to develop drug depot systems and illustrated as a novel dermal and topical drug delivery vehicle for non-steroidal anti-inflammatory drug molecules. FAE's (Fatty acid ethyl and isopropyl esters) with different chain lengths, ethyl laurate, ethyl myristate, ethyl palmitate, isopropyl laurate, isopropyl myristate, isopropyl ...
Tópico(s): Lipid Membrane Structure and Behavior
2016 - Elsevier BV | Tetrahedron
Nursen İlçin, Barış GÜRPINAR, Deniz Bayraktar, Sema Savcı, P. Cetin, İ̇smail Sarı, Nurullah Akkoç,
This study describes the cultural adaptation, validation, and reliability of the Turkish version of the Pain Catastrophizing Scale in patients with ankylosing spondylitis.[Methods] The validity of the Turkish version of the Pain Catastrophizing Scale was assessed by evaluating data quality (missing data and floor and ceiling effects), principal components analysis, internal consistency (Cronbach's alpha), and construct validity (Spearman's rho).Reproducibility analyses included standard measurement ...
Tópico(s): Spondyloarthritis Studies and Treatments
2016 - Penerbit Universiti Sains Malaysia | Journal of Physical Therapy Science
Ali Coşkun, Nazif Erkan, Savaş Yakan, Mehmet Yıldırım, Erdem Barış Cartı, Deniz A. Uçar, Erkan Oymacı,
Hypertriglyceridaemia (HT)-induced pancreatitis rarely occurs unless triglyceride levels exceed 1000 mg/dl. Hypertriglyceridaemia over 1,000 mg/dl can provoke acute pancreatitis (AP) and its persistence can worsen the clinical outcome. In contrast, a rapid decrease in triglyceride level is beneficial. Insulin-stimulated lipoprotein lipase is known to decrease serum triglyceride levels. However, their efficacy in HT-induced AP is not well documented.To present 12 cases of AP successfully treated by ...
Tópico(s): Lipid metabolism and disorders
2015 - Termedia Publishing House | Gastroenterology Review
Barış Malbora, Deniz Yüksel, Ayşe Aksoy, Mehpare Özkan,
Background In developing countries, nutritional vitamin B12 deficiency in infants because of maternal deficiency often causes hematological and neurological disorders. However, epilepsy is a rare manifestation of vitamin B12 deficiency. The biological basis for the observed neurological symptoms of infantile vitamin B12 deficiency remains uncertain. There are only a few reports in the English literature regarding the relationship between infantile spasms and vitamin B12 deficiency. Patients We report ...
Tópico(s): Metabolism and Genetic Disorders
2014 - Elsevier BV | Pediatric Neurology
Barıș Önol, Deniz Bozkurt, Ufuk Utku Turunçoǧlu, Ömer Lütfi Şen, H. Nüzhet Dalfes,
Tópico(s): Atmospheric and Environmental Gas Dynamics
2013 - Springer Science+Business Media | Climate Dynamics
Pınar Kahraman Koytak, Barış İşak, Deniz Borucu, Kayıhan Uluç, Tülin Tanrıdağ, Önder Us,
Abstract Established electrophysiological methods have limited clinical utility in the diagnosis of small‐fiber neuropathy (SFN). In this study, diabetic patients with clinically diagnosed SFN were evaluated with autonomic tests and cutaneous silent periods (CSPs). Thirty‐one diabetic patients with clinically suspected SFN and normal nerve conduction studies were compared with 30 controls. In the upper extremities (UE), the CSP parameters did not differ statistically between the patient and control ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2011 - Wiley | Muscle & Nerve
Murat Çetinkaya, Firdevs Tulga Öz, Ayşe Işıl Orhan, Kaan Orhan, Barış Karabulut, Deniz C. Can-Karabulut, Özlem İlk,
Tópico(s): Teratomas and Epidermoid Cysts
2011 - Elsevier BV | International Dental Journal
A. Eleftheriou, E. ANAGNOSTOPOULOU – VISILIA, E. Anastasopoulou, A. Suat Ateş, Nour El Islam Bachari, Levent Çavaş, Cem Çevik, M. ULHA, Fatma Çevik, A. L. Delos, Osman Barış Derici, Deniz Ergüden, Nina Fragopoulu, Adriana Giangrande, Tolga Göksan, Cinzia Gravili, Mevlüt Gürlek, Abdallah Hattour, Kostas Kapiris, Petros Kouraklis, Souad Lamouti, Ermelinda Prato, Loredana Papa, Georgia Papantoniou, Isabella Parlapiano, Dimitris Poursanidis, Cemal Turan, Deniz Yağlıoğlu,
no abstract
Tópico(s): Marine Invertebrate Physiology and Ecology
2011 - Hellenic Centre for Marine Research | Mediterranean Marine Science
Deniz Barış, Murat Kızıl, Çetin Aytekin, Göksel Kızıl, Murat Yavuz, Bircan Çeken, Alaattin Selçuk Ertekin,
The present study was conducted to determine the antimicrobial, antifungal and antioxidant activity of the ethanol extract of Hypericum scabrum L (HSm), Hypericum lysimachioides var. lysimachioides (HL), and Hypericum retusum Aucher (HR) and ethanol extracts of Achillea aleppica D.C. subsp. aleppica (AA), Achillea aleppica D.C. subsp. zederbaueri (Hayek) Hub.-Mor (AZ), and Achillea biebersteinii Afan. (AB). The antioxidant properties of extracts were evaluated using different antioxidants tests, including ...
Tópico(s): Essential Oils and Antimicrobial Activity
2010 - Marcel Dekker | International Journal of Food Properties