Produção Nacional
Revisado por pares
Diego Simeone, Cláudia Helena Tagliaro, Colin Robert Beasley,
Tópico(s): Environmental Toxicology and Ecotoxicology
2021 - Springer Science+Business Media | Hydrobiologia
Produção Nacional
Revisado por pares
Diego Simeone, Cláudia Helena Tagliaro, Colin Robert Beasley,
Mussels have important ecological functions in freshwater ecosystems, but populations are declining in many rivers worldwide. In the Amazon, which is undergoing widespread human-mediated alterations, information on mussel ecology is lacking. We investigated whether declines in mussel density, due to exploitation, are associated with lower macroinvertebrate assemblage taxon richness and modified habitat functioning in an Amazonian river. Between 2015 and 2017, macroinvertebrate metrics of abundance ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2020 - Elsevier BV | Ecological Indicators
Produção Nacional
Revisado por pares
Diego Simeone, Cristiney Santos, Flávia Gisane, Cláudia Helena Tagliaro, Colin Robert Beasley,
Abstract Meanders are complex aquatic environments exhibiting different flow and sediment characteristics that influence macroinvertebrate distribution. Differences in macroinvertebrate composition, freshwater mussel density (mainly Castalia ambigua Lamarck, 1819) and habitat variables were investigated, using uni‐ and multivariate analyses, in two zones, the margin and thalweg, of the meanders of a 7‐km stretch of a morphologically unaltered tropical alluvial lowland river. Clear differences were ...
Tópico(s): Freshwater macroinvertebrate diversity and ecology
2018 - Wiley | Freshwater Biology
Produção Nacional
Revisado por pares
Diego Simeone, Cláudia Helena Tagliaro, Jeovana Oliveira Lima, Colin Robert Beasley,
Shell shape variation of the freshwater mussel Castalia ambigua in relation to environmental and genetic drivers remains unresolved in South America. Along an increasing upstream to downstream hydrological gradient in the Caeté River, eastern Amazon, Brazil, we evaluated two co-occurring morphotypes of C. ambigua: the first is elongated and compressed; the second is rounded and inflated. We performed multivariate shape analysis on the lateral view of the right valve and the umbonal view, to identify ...
Tópico(s): Fish Ecology and Management Studies
2022 - Springer Science+Business Media | Zoomorphology
Produção Nacional
Revisado por pares
Diego Simeone, Cláudia Helena Tagliaro, Colin Robert Beasley,
Novel insights into habitat suitability for two Unionida freshwater mussels,
Tópico(s): Environmental Toxicology and Ecotoxicology
2021 - Wiley | Ecology and Evolution
Produção Nacional
Revisado por pares
Liliane Sousa da Mata, Cláudia Helena Tagliaro, Diego Simeone, Colin Robert Beasley,
The shells of unionid freshwater mussels are highly morphologically variable, making species identification difficult and thus hampering conservation efforts. Shell shape variation is associated with several factors, of which hydrodynamic variables are the most common. Using geometric morphometrics, shell shape was evaluated on the basis of both external (entire margin including alate processes) and internal (pallial line and positions of muscle scars and teeth) landmarks in Triplodon corrugatus, ...
Tópico(s): Shoulder and Clavicle Injuries
2019 - Oxford University Press | Journal of Molluscan Studies
V. Simeone, Nuray Baser, Diego Cavalcanti Perrelli, Gianluigi Cesari, Hamid El Bilali, Patrizia Natale,
Rotenone, azadirachtin, pyrethrins and copper fungicide decay curves were determined in olives and olive oil samples after experimental trials, consisting of one, two and three applications of each active ingredient, were carried out twice in 2005 and 2006. Rotenone, azadiracthin and pyrethrins were analyzed by extraction with acetonitrile and determined by liquid chromatography; copper was extracted into aqueous HCl and determined by chemical stripping. Pyrethrins were always found but in levels ...
Tópico(s): Insect behavior and control techniques
2009 - Taylor & Francis | Food Additives & Contaminants Part A
Ines Simeone, Carmela Rubolino, Teresa Noviello, Diego Farinello, Luigi Cerulo, Matteo Jacopo Marzi, Francesco Nicassio,
It is currently unknown how many RNA transcripts are able to induce degradation of microRNAs (miRNA) via the mechanism known as target-directed miRNA degradation (TDMD). We developed TDMDfinder, a computational pipeline that identifies 'high confidence' TDMD interactions in the Human and Mouse transcriptomes by combining sequence alignment and feature selection approaches. Our predictions suggested that TDMD is widespread, with potentially every miRNA controlled by endogenous targets. We experimentally ...
Tópico(s): MicroRNA in disease regulation
2022 - Oxford University Press | Nucleic Acids Research
Anna Maria Di Giacomo, Paolo A. Ascierto, Lorenzo Pilla, Mario Santinami, Pier Francesco Ferrucci, Diana Giannarelli, Antonella Marasco, Licia Rivoltini, Ester Simeone, Stefania VL Nicoletti, Ester Fonsatti, Diego Annesi, Paola Queirolo, Alessandro Testori, Ruggero Ridolfi, Giorgio Parmiani, Michele Maio,
Background Ipilimumab improves survival of patients with metastatic melanoma, many of whom develop brain metastases. Chemotherapy-induced release of tumour antigens might amplify ipilimumab's antitumour activity. We aimed to investigate the efficacy and safety of ipilimumab plus fotemustine in patients with metastatic melanoma with or without asymptomatic brain metastases. Methods In our open-label, single-arm phase 2 trial, we enrolled patients 18 years or older with measurable, locally advanced, ...
Tópico(s): Immunotherapy and Immune Responses
2012 - Elsevier BV | The Lancet Oncology
Michele Scialpi, Valeria Rondoni, Maria Cristina Aisa, Eugenio Martorana, Alfredo D’Andrea, Corrado Maria Malaspina, Agostino Orlandi, Giorgio Galassi, Emanuele Orlandi, Pietro Scialpi, Michele Dragone, Diego Palladino, Annalisa Simeone, M. Amenta, Giampaolo Bianchi,
Abstract: Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) provides clinical guidelines for multiparametric magnetic resonance imaging (mpMRI) [T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)] of prostate. However, DCE-MRI seems to show a limited contribution in prostate cancer (PCa) detection and management. In our experience, DCE-MRI, did not show significant change in diagnostic performance in addition to ...
Tópico(s): Urologic and reproductive health conditions
2017 - AME Publishing Company | Translational Andrology and Urology
Giulia Roberta Ercolino, Giuseppe Guglielmi, Luca Pazienza, Filomena Urbano, Diego Palladino, Anna Simeone,
Malignant melanoma development in gastrointestinal (GI) tract may be primary or secondary. Although small bowel, colon and stomach represent common GI sites affected from metastatic cutaneous malignant melanoma (cMM), more than 90% of the cases are identified only during autoptic examinations. Therefore, the diagnosis in a living patient of gallbladder metastasis from cMM is considered extremely rare. We aimed to describe a case of metastatic melanoma involving the gallbladder, the stomach and the ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2018 - British Institute of Radiology | BJR|case reports
Emmanouil Athanasakis, E. Melloni, Gian Matteo Rigolin, Chiara Agnoletto, Rebecca Voltan, Diego Vozzi, Elisa Piscianz, Ludovica Segat, Simeone Dal Monego, Antonio Cuneo, Paola Secchiero, Giorgio Zauli,
... Rigolin 3 , Chiara Agnoletto 2 , Rebecca Voltan 2 , Diego Vozzi 1 , Elisa Piscianz 1 , Ludovica Segat 1 , Simeone Dal Monego 4 , Antonio Cuneo 3 , Paola Secchiero ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2014 - Impact Journals LLC | Oncotarget
Produção Nacional
Revisado por pares
Gisele do Carmo Reis, Diego Simeone, Colin Robert Beasley,
Information on freshwater mussel behavior in the sediment is scarce worldwide, especially in the Amazon. Laboratory experiments were used to measure the responses of the single mussel species
Tópico(s): Marine Bivalve and Aquaculture Studies
2023 - Wiley | Ecology and Evolution
Ali Abdel Raheem, Ibrahim Alowidah, Umberto Capitanio, Francesco Montorsi, Alessandro Larcher, Ithaar Derweesh, Fady Ghali, Alexandre Mottrie, Elio Mazzone, Geert De Naeyer, Riccardo Campi, Francesco Sessa, Marco Carini, Andrea Minervini, Jay D. Raman, Chris Rjepaj, Maximilian C. Kriegmair, Riccardo Autorino, Alessandro Veccia, Maria Carmen Mir, Francesco Claps, Young Deuk Choi, Won Sik Ham, John Paul Tadifa, Glen Denmer Santok, Maria Furlan, Claudio Simeone, Maida Bada, Antonio Celia, Diego M. Carrión, Alfredo Aguilera Bazán, Cristina Ballesteros Ruiz, Manar Malki, Neil Barber, Muddassar Hussain, Salvatore Micali, Stefano Puliatti, Abdelaziz Alwahabi, Abdulrahman Alqahtani, Abdullah Rumaih, Ahmed Ghaith, Ayman Ghoneem, Ayman Hagras, Ahmed Eissa, Mohamed Jayed Alenzi, Nicola Pavan, Fabio Traunero, Alessandro Antonelli, Antonio Benito Porcaro, Ester Illiano, Elisabetta Costantini, Koon Ho Rha,
The impact of warm ischemia time (WIT) on renal functional recovery remains controversial. We examined the length of WIT>30 min on the long-term renal function following on-clamp partial nephrectomy (PN).Data from 23 centers for patients undergoing on-clamp PN between 2000 and 2018 were analyzed. We included patients with two kidneys, single tumor, cT1, minimum 1-year follow-up, and preoperative eGFR≥60 mL/min/1.73m2. Patients were divided into two groups according to WIT length: group I "WIT≤30 min" ...
Tópico(s): MRI in cancer diagnosis
2021 - | Minerva Urology and Nephrology
Paola Briata, Rinke Van De Werken, Irma Airoldi, Cristina Ilengo, Erica Di Blas, Edoardo Boncinelli, Giorgio Corte,
... Stornaiuolo A. Mallamaci A. Migliaccio E. Gulisano M. Simeone A. Boncinelli E. Nucleic Acids Res. 1992; 23: 6541-6545Google Scholar) in the filled in BamHI cloning site of pVL941 (Pharmingen, San Diego, CA). Recombinant baculovirus particles (Baculogold/EVX1) were obtained ... Stornaiuolo A. Mallamaci A. Migliaccio E. Gulisano M. Simeone A. Boncinelli E. Nucleic Acids Res. 1992; 23: 6541-6545Google Scholar) into the Klenow-filled in HindIII site of the pRC-CMV expression vector purchased from Invitrogen Corp. (San Diego, CA). The pCMV-HOXD4 expression construct was generated ...
Tópico(s): Developmental Biology and Gene Regulation
1995 - Elsevier BV | Journal of Biological Chemistry
Paolo Soda, Natascha Claudia D’Amico, Jacopo Tessadori, Giovanni Valbusa, Valerio Guarrasi, Chandra Bortolotto, Muhammad Usman Akbar, Rosa Sicilia, Ermanno Cordelli, Deborah Fazzini, Michaela Cellina, Giancarlo Oliva, Giovanni Callea, Silvia Panella, Maurizio Cariati, Diletta Cozzi, Vittorio Miele, Elvira Stellato, Gianpaolo Carrafiello, Giulia Castorani, Annalisa Simeone, Lorenzo Preda, Giulio Iannello, Alessio Del Bue, Fabio Tedoldi, Marco Alì, Diego Sona, Sergio Papa,
Recent epidemiological data report that worldwide more than 53 million people have been infected by SARS-CoV-2, resulting in 1.3 million deaths. The disease has been spreading very rapidly and few months after the identification of the first infected, shortage of hospital resources quickly became a problem. In this work we investigate whether artificial intelligence working with chest X-ray (CXR) scans and clinical data can be used as a possible tool for the early identification of patients at risk ...
Tópico(s): Artificial Intelligence in Healthcare and Education
2021 - Elsevier BV | Medical Image Analysis
Fausta Ciccocioppo, Paola Lanuti, Laura Pierdomenico, Pasquale Simeone, Giuseppina Bologna, Eva Ercolino, Fabio Buttari, Roberta Fantozzi, Astrid Thomas, Marco Onofrj, Diego Centonze, Sebastianó Miscia, Marco Marchisio,
Regulatory T Cells (Tregs) are a T-lymphocyte subset involved in the maintenance of immune peripheral tolerance. Despite evidence of the adaptive immune system's role in Alzheimer's Disease (AD), the involvement of Tregs is still not clear. We focused on the Flow-Cytometry analysis of the Treg frequencies and phenotypes in the AD. The aim of the study is to analyse similarities and differences in Tregs profile between Alzheimer's Disease and Multiple Sclerosis. Regulatory T Cells (CD4+/CD25high/CD127low- ...
Tópico(s): T-cell and B-cell Immunology
2019 - Nature Portfolio | Scientific Reports
Giuseppe Lombardi, Alessandro Spimpolo, Sara Berti, Cristina Campi, Maria Giulia Anglani, Rossella Simeone, Laura Evangelista, Francesco Causin, Giovanni Zorzi, Giancarlo Gorgoni, Mario Caccese, Marta Padovan, Vittorina Zagonel, Diego Cecchin,
Objective: The use of regorafenib in recurrent glioblastoma patients has been recently approved by the Italian Medicines Agency (AIFA) and added to the National Comprehensive Cancer Network (NCCN) 2020 guidelines as a preferred regimen. Given its complex effects at the molecular level, the most appropriate imaging tools to assess early response to treatment is still a matter of debate. Diffusion-weighted imaging and O-(2-18F-fluoroethyl)-L-tyrosine positron emission tomography ([18F]FET PET) are promising ...
Tópico(s): Medical Imaging Techniques and Applications
2021 - Wiley | British Journal of Radiology
Anna Maria Di Giacomo, Paolo A. Ascierto, Paola Queirolo, Lorenzo Pilla, Ruggero Ridolfi, Mario Santinami, Alessandro Testori, Ester Simeone, Massimo Guidoboni, Andrea Maurichi, L. Orgiano, Giuseppe Spadola, Michele Del Vecchio, Riccardo Danielli, Luana Calabrò, Diego Annesi, Diana Giannarelli, Cristina Maccalli, Ester Fonsatti, Giorgio Parmiani, Michele Maio,
ABSTRACT Long-term analysis of the NIBIT-M1 trial continues to demonstrate efficacy of the combination of ipilimumab and fotemustine in metastatic melanoma patients with or without brain metastases. The addition of fotemustine to ipilimumab does not impair its immunomodulatory activity. Background In the NIBIT-M1 study, we reported a promising activity of ipilimumab combined with fotemustine in metastatic melanoma (MM) patients with or without brain metastases. To corroborate these initial findings, we now ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2014 - Elsevier BV | Annals of Oncology
Michele Scialpi, Alfredo D’Andrea, Eugenio Martorana, Corrado Maria Malaspina, Maria Cristina Aisa, Maria Napoletano, Emanuele Orlandi, Valeria Rondoni, Pietro Scialpi, Diamante Pacchiarini, Diego Palladino, Michele Dragone, Gian Carlo Di Renzo, Annalisa Simeone, Giampaolo Bianchi, Luca Brunese,
Biparametric Magnetic Resonance Imaging (bpMRI) of the prostate combining both morphologic T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) is emerging as an alternative to multiparametric MRI (mpMRI) to detect, to localize and to guide prostatic targeted biopsy in patients with suspicious prostate cancer (PCa). BpMRI overcomes some limitations of mpMRI such as the costs, the time required to perform the study, the use of gadolinium-based contrast agents and the lack of a guidance for ...
Tópico(s): Urologic and reproductive health conditions
2017 - | Turkish journal of urology
Francesca Desiderio, Davide Guerra, Diego Rubiales, Luciana Piarulli, Marina Pasquini, Anna Maria Mastrangelo, Rosanna Simeone, Antonio Blanco, Luigi Cattivelli, Giampiero Valé,
Tópico(s): Genetics and Plant Breeding
2014 - Springer Science+Business Media | Molecular Breeding
Diego Scognamiglio, Lucia Russo, Pier Luca Maffettone, L. Salemme, M. Simeone, Silvestro Crescitelli,
A model of a ATR fixed bed reactor with Rh catalyst has been developed and validated on the basis of experimental results. Experiments have been conducted in a small scale reactor and solid temperature profiles have been measured with IR camera. Temperature profiles present high peak temperature at reactor entrance as consequence of the partial separation in space of the reforming and oxidation reactions. Thus, the kinetic model for Rh catalyst refers to an indirect scheme including a shift factor ...
Tópico(s): Catalysis and Oxidation Reactions
2011 - Elsevier BV | International Journal of Hydrogen Energy
Diego Scognamiglio, Lucia Russo, Pier Luca Maffettone, L. Salemme, M. Simeone, Silvestro Crescitelli,
In this work, a one-dimensional heterogeneous model for the autothermal reforming of methane in a catalytic (Ni/Al2O3 catalyst) fixed-bed reactor is proposed. The kinetic model implements an indirect reaction scheme and includes a reduction factor that is dependent on the oxygen concentration. Such a factor delays the reforming and water-gas shift reactions, with respect to the oxidation reactions. Experiments at different steam-to-methane ratios and feed flow rates were conducted in a small-scale ...
Tópico(s): Catalysis and Oxidation Reactions
2009 - American Chemical Society | Industrial & Engineering Chemistry Research
Afrânio Gonçalves Neto, A Freitas, Miguel Arantes Normanha Filho, Kailany Milena Moreira Corrêa, Diego Simeone,
Objetivo: Evidenciar a experiência de acadêmicos de medicina diante do acompanhamento domiciliar a paciente com lesão raquimedular durante 6 meses, observar as necessidades, desafios, assistência e convívio social diante do quadro de saúde apresentado, buscar estratégias de intervenções que possam melhorar ou amenizar os problemas de saúde do paciente. Método: trata-se de um relato de experiência descritivo com abordagem qualitativa pautado em visitas domiciliares. Resultados: Por meio dessas visitas, ...
Tópico(s): Nonmelanoma Skin Cancer Studies
2025 - | Saúde Coletiva (Barueri)
Produção Nacional
Revisado por pares
Cristiney Santos, Diego Simeone, Colin Robert Beasley,
In aquatic ecosystems, benthic macroinvertebrates are strongly influenced by riparian habitat quality. We investigated associations between riparian deforestation, stream habitat variables and benthic macroinvertebrate assemblage structure, particularly sensitive taxa. We sampled macroinvertebrates and physical-chemical variables during both the dry and wet seasons at three sites, each with low, medium, and high levels of riparian deforestation, in each of three first-order streams in the lower ...
Tópico(s): Aquatic Invertebrate Ecology and Behavior
2024 - Taylor & Francis | Studies on Neotropical Fauna and Environment
Produção Nacional
Revisado por pares
Diego Simeone, Aurycéia Guimarães‐Costa,
During the COVID-19 pandemic, H1N1 seasonality disappeared worldwide. In Brazil, information on how coronavirus impacted this seasonality is scarce. In this study, we aimed to verify whether COVID-19 pandemic was associated with changes in the seasonality of H1N1, modeling the time series of H1N1 between pre-pandemic (2018 and 2019), pandemic (2020 and 2021) and post-pandemic (2022 and 2023) periods. For this purpose, we superimposed on this time series cases of COVID-19 from 2020 to 2023. Our findings ...
Tópico(s): COVID-19 impact on air quality
2024 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências
Produção Nacional
Revisado por pares
Juliana Teixeira-Santos, Diego Simeone,
Enhanced mammal functional diversity is crucial for forest ecological functioning. However, this group is affected by habitat degradation, such as mineral exploitation, which is a major threat worldwide. In these habitats, the maintenance of forest patches is important to support species diversity. Here, we addressed this knowledge gap by examining the functional diversity of medium-sized mammals among forest patches of different sizes in an area of approximately 3195 ha that is used for copper ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2023 - Elsevier BV | Acta Oecologica
Simeone Diego, Tagliaro Claudia Helena, Beasley Colin Robert,
2021 - Elsevier BV | Ecological Indicators
Abstract Studies relating to fish trophic ecology provide important insights regarding their life history. However, there is a lack of information linking fish diet composition with riparian cover in small streams. To investigate whether diet composition varied between streams with pristine and logged forests, I compared the food items consumed by four characid species: Bryconops melanurus , Moenkhausia collettii , Moenkhausia dichroura, and Moenkhausia oligolepis . I sampled 18 first‐order streams in ...
Tópico(s): Fish Biology and Ecology Studies
2023 - Wiley | Ecology Of Freshwater Fish
... legend and the coach of Atletico Madrid team – Diego Simeone – is Hero MotoCorp’s Brand Ambassador.Hero MotoCorp ...
Tópico(s): Entrepreneurship Studies and Influences
2022 - RELX Group (Netherlands) | SSRN Electronic Journal