Dmitriy I. Vodolazhsky, Denis S. Kutilin, Leonid Kharin, Evgeniy N. Kolesnikov, Олеся Богданова, Vyacheslav A. Sustretov, Vladimir S. Trifanov, Oleg I. Kit,
e23007 Background: Over the past 20 years, the number of deaths from colorectal cancer (CRC) increased by 46% worldwide: every year more than 1 million people are diagnosed with this pathology. Proteomic studies using protein microarrays are a very attractive strategy for the screening of new highly specific biomarkers which can improve prognosis prediction of CRC. We performed a screening proteomic study to find new informative biomarkers for metastatic and non-metastatic colorectal cancer which ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2017 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Oleg I. Kit, Dmitriy I. Vodolazhsky, Denis S. Kutilin, Yaroslav S. Enin, Yuri Gevorkyan, Leonid Kharin, Svetlana Panina,
608 Background: Colorectal cancer is the second most common cancer in women and third most common cancer in men. Major signaling pathways are known to be deregulated in cancer, however, there are only a few studies addressing activation status of more than one or two pathways in colorectal cancer in comparison with the normal tissue. The present study aims to compare the expression pattern of proteins associated with cell signaling in paired tumor and non-tumor samples of patients with colon cancer, ...
Tópico(s): Cancer, Lipids, and Metabolism
2018 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Denis S. Kutilin, Yaroslav S. Enin, Dmitriy I. Vodolazhsky, Vyacheslav A. Sustretov, Tamara G. Ayrapetova, Pavel А. Anistratov, Sergey P. Pyltsin, Igor A. Leyman, Anna V. Chubaryan, Олеся Богданова, Leonid Kharin, Igor N. Turkin, Maxim N. Dyritsky, Oleg I. Kit,
e23094 Background: Today, the problem of early diagnostics of lung cancer remains unsolved as every fourth patient diagnosed with the disease already has distant metastases. Studying gene copy number variation (CNV) in extracellular DNA in the blood plasma can become a basis for a new effective and low invasive method for predictive diagnostics and disease prognosis. The purpose of the study was to examine the copy number of the MDM2 and p53 genes in extracellular DNA of patients with metastatic ...
Tópico(s): Medical Imaging and Pathology Studies
2017 - Lippincott Williams & Wilkins | Journal of Clinical Oncology