Mathieu F. Chevalier, Sara Trabanelli, Julien Racle, Bérengère Salomé, Valérie Cesson, Dalila Gharbi, Perrine Bohner, Sonia Domingos‐Pereira, Florence Dartiguenave, Anne-Sophie Fritschi, Daniel E. Speiser, Cyrill A. Rentsch, David Gfeller, Patrice Jichlinski, Denise Nardelli‐Haefliger, Camilla Jandus, Laurent Derré,
Non-muscle-invasive bladder cancer (NMIBC) is a highly recurrent tumor despite intravesical immunotherapy instillation with the bacillus Calmette-Guérin (BCG) vaccine. In a prospective longitudinal study, we took advantage of BCG instillations, which increase local immune infiltration, to characterize immune cell populations in the urine of patients with NMIBC as a surrogate for the bladder tumor microenvironment. We observed an infiltration of neutrophils, T cells, monocytic myeloid-derived suppressor ...
Tópico(s): Immune cells in cancer
2017 - American Society for Clinical Investigation | Journal of Clinical Investigation
From Our Special Correspondent, From Our Newmarket Correspondent, From Our Bowls Correspondent, From Our Cricket Correspondent, From Our Yachting Correspondent, From Our Lawn Tennis Correspondent, From Our Labour Correspondent, From A Correspondent, By Callisthenes, From A Special Correspondent, From Our Motoring Correspondent, From Our Own Correspondent, From Our Correspondent, Our Warsaw Correspondent, From Our Diplomatic Correspondent, From Our Shipping Correspondent, Our Naval Correspondent, From Our Naval Correspondent, Horace Rumbold., R. Coupland., R. A. Williams., Geoffrey Le M. Mander., H. Arnold Woolley., Guy M. Kindersley., By Sir Ronald Davison, From Our Civil Service Correspondent, From Our Bridge Correspondent, Peter E. Brassey., H. Kyffin Heyland., John Leigh., Herbert S. Syrett., N. Crosby., Colonel, T.A., John Buckley., Robert P. Skinner., Stamp., D. A. Anderson., From Our Philatelic Correspondent, From Our Lisbon Correspondent, By Professor R. Coupland, C.I.E., By H. Hallam Hipwell, By J. R. Eden, By Engenheiro F. Pinto Teixeira, By Vivian L. Oury, By Dr. Eurico Jos� De Loureiro E Amaral, By E. Ribeiro, By General Ferreira Martins, By Dr. F. Alves De Azevedo, By Dr. Domingos Menezes, By Dr. A. Augusto Pereira Cabral, By Padre Manuel Alves Correia, By The Rev. E. Lloyd Sporne, By Dr. Vasco Palmeirim, Director Of Health Services In The Colony, By R. C. F. Maugham, By Dr. J. Ramsbottom, By Aubrey F. G. Bell, By Malcolm Burr, By Professor Reynaldo Dos Santos,
Births. Marriages. Deaths. Classified Advertising: Miscellaneous Financial, Educational, Public Appointments, Business Offers, Legal Notices, Entertainments ...
1939 - Gale Group | TDA
Loane Decrausaz, Ana Rita Gonçalves, Sonia Domingos‐Pereira, Christelle Pythoud, Jean‐Christophe Stehle, John T. Schiller, Patrice Jichlinski, Denise Nardelli‐Haefliger,
Abstract Cervical cancer results from infection with high‐risk type human papillomaviruses (HPV). Therapeutic vaccines aiming at controlling existing genital HPV infections and associated lesions are usually tested in mice with HPV‐expressing tumor cells subcutaneously implanted into their flank. However, effective vaccine‐induced regression of these ectopic tumors strongly contrasts with the poor clinical results of these vaccines produced in patients with HPV‐associated genital neoplasia. To assess ...
Tópico(s): Immune Response and Inflammation
2010 - Wiley | International Journal of Cancer
... 31S.) " Chronica da Companhia de Jesus " of Father Domingos de Araujo, 1721); from the diary of a ... the Marahão, on the request of Diogo Rodriquez Pereira, captain of the fort of the Rio Negro, ...
1729 - Gale Group | SASII
Loane Decrausaz, Sonia Domingos‐Pereira, Mélanie Duc, Martine Bobst, Pedro Romero, John T. Schiller, Patrice Jichlinski, Denise Nardelli‐Haefliger,
Cervical cancer is a public health concern as it represents the second cause of cancer death in women worldwide. High-risk human papillomaviruses (HPV) are the etiologic agents, and HPV E6 and/or E7 oncogene-specific therapeutic vaccines are under development to treat HPV-related lesions in women. Whether the use of mucosal routes of immunization may be preferable for inducing cell-mediated immune responses able to eradicate genital tumors is still debated because of the uniqueness of the female ...
Tópico(s): Hepatitis B Virus Studies
2011 - Wiley | International Journal of Cancer
... 31S.) " Chronica da Companhia de Jesus " of Father Domingos de Araujo, 1721); from the diary of a ... the Marahão, on the request of Diogo Rodriquez Pereira, captain of the fort of the Rio Negro, ...
1729 - Gale Group | SASII
Produção Nacional
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Tópico(s): History of Colonial Brazil
2006 - UNIVERSIDADE FEDERAL DA BAHIA | Afro-Ásia
... 31S.) " Chronica da Companhia de Jesus " of Father Domingos de Araujo, 1721); from the diary of a ... the Marahão, on the request of Diogo Rodriquez Pereira, captain of the fort of the Rio Negro, ...
1729 - Gale Group | SASII
Sonia Domingos‐Pereira, Loane Decrausaz, Laurent Derré, Martine Bobst, Pablo Romero, John T. Schiller, Patrice Jichlinski, Denise Nardelli‐Haefliger,
Human papillomaviruses (HPV)-related cervical cancer is the second leading cause of cancer death in women worldwide. Despite active development, HPV E6/E7 oncogene-specific therapeutic vaccines have had limited clinical efficacy to date. Here, we report that intravaginal (IVAG) instillation of CpG-ODN (TLR9 agonist) or poly-(I:C) (TLR3 agonist) after subcutaneous E7 vaccination increased ∼fivefold the number of vaccine-specific interferon-γ-secreting CD8 T cells in the genital mucosa (GM) of mice, without ...
Tópico(s): Cervical Cancer and HPV Research
2012 - Elsevier BV | Mucosal Immunology
... 31S.) " Chronica da Companhia de Jesus " of Father Domingos de Araujo, 1721); from the diary of a ... the Marahão, on the request of Diogo Rodriquez Pereira, captain of the fort of the Rio Negro, ...
1729 - Gale Group | SASII
Florian Alonso, Sonia Domingos‐Pereira, Loïc Le Gal, Laurent Derré, Paolo Meda, Patrice Jichlinski, Denise Nardelli‐Haefliger, Jacques‐Antoine Haefliger,
Endothelial connexin40 (Cx40) contributes to regulate the structure and function of vessels. We have examined whether the protein also modulates the altered growth of vessels in tumor models established in control mice (WT), mice lacking Cx40 (Cx40-/-), and mice expressing the protein solely in endothelial cells (Tie2-Cx40). Tumoral angiogenesis and growth were reduced, whereas vessel perfusion, smooth muscle cell (SMC) coverage and animal survival were increased in Cx40-/- but not Tie2-Cx40 mice, revealing ...
Tópico(s): Redox biology and oxidative stress
2016 - Impact Journals LLC | Oncotarget
... 31S.) " Chronica da Companhia de Jesus " of Father Domingos de Araujo, 1721); from the diary of a ... the Marahão, on the request of Diogo Rodriquez Pereira, captain of the fort of the Rio Negro, ...
1729 - Gale Group | SASII
Sonia Domingos‐Pereira, Valérie Cesson, Mathieu F. Chevalier, Laurent Derré, Patrice Jichlinski, Denise Nardelli‐Haefliger,
Intravesical Bacillus-Calmette-Guérin (BCG) immunotherapy can reduce recurrence/progression of non-muscle-invasive bladder cancer (NMIBC), although significant adverse events and treatment failure argue for alternative options. Here, we examined whether another attenuated live vaccine, Vivotif/Ty21a, used since more than 30 y against typhoid fever, may be safely used intravesically to improve bladder-tumor treatment. Mice-bearing MB49 orthotopic bladder-tumors treated with intravesical Ty21a or BCG ...
Tópico(s): Cancer Research and Treatments
2016 - Landes Bioscience | OncoImmunology
... 31S.) " Chronica da Companhia de Jesus " of Father Domingos de Araujo, 1721); from the diary of a ... the Marahão, on the request of Diogo Rodriquez Pereira, captain of the fort of the Rio Negro, ...
1729 - Gale Group | SASII
Produção Nacional
Revisado por pares
Carla Lauise Rodrigues Menezes Pimenta, Diego Figueiredo da Costa, Maria Luana Cristiny Rodrigues Silva, Hélio Domingos Pereira, João Pessoa Araújo Júnior, Camila Dantas Malossi, Leila Sabrina Ullmann, Clebert José Alves, Sérgio Santos de Azevêdo,
The aim of the present study was to describe the strategies of the control of an outbreak of leptospiral infection in dairy cattle in Maranhão State, Northeastern Brazil. In the period from January to July 2015, 18 (17%) out of 106 cows presented abortion, six (5.7%) stillbirth, and 12 (11.3%) repeated estrus, totaling 24 animals with reproductive problems. The diagnosis of leptospirosis was based on serology (microscopic agglutination test—MAT), bacteriological culture, and polymerase chain reaction ( ...
Tópico(s): Veterinary medicine and infectious diseases
2018 - Springer Science+Business Media | Tropical Animal Health and Production
... 31S.) " Chronica da Companhia de Jesus " of Father Domingos de Araujo, 1721); from the diary of a ... the Marahão, on the request of Diogo Rodriquez Pereira, captain of the fort of the Rio Negro, ...
1729 - Gale Group | SASII
Gabriele Galliverti, Mélanie Tichet, Sonia Domingos‐Pereira, Sylvie Hauert, Denise Nardelli‐Haefliger, Melody A. Swartz, Douglas Hanahan, Stephan Wullschleger,
Treatment of patients bearing human papillomavirus (HPV)-related cancers with synthetic long-peptide (SLP) therapeutic vaccines has shown promising results in clinical trials against premalignant lesions, whereas responses against later stage carcinomas have remained elusive. We show that conjugation of a well-documented HPV-E7 SLP to ultra-small polymeric nanoparticles (NP) enhances the antitumor efficacy of therapeutic vaccination in different mouse models of HPV+ cancers. Immunization of TC-1 tumor- ...
Tópico(s): vaccines and immunoinformatics approaches
2018 - American Association for Cancer Research | Cancer Immunology Research
... 31S.) " Chronica da Companhia de Jesus " of Father Domingos de Araujo, 1721); from the diary of a ... the Marahão, on the request of Diogo Rodriquez Pereira, captain of the fort of the Rio Negro, ...
1729 - Gale Group | SASII
Sonia Domingos‐Pereira, Gabriele Galliverti, Douglas Hanahan, Denise Nardelli‐Haefliger,
High-risk human papillomavirus (HPV) are responsible for genital and oral cancers associated with the expression of the E6/E7 HPV oncogenes.Therapeutic vaccines targeting those oncogenes can only partially control tumor progression, highlighting the necessity to investigate different treatment strategies.Using the genital orthotopic HPV16 TC-1 model, herein we sequentially investigated in progressively more stringent settings the effects of systemic administration of carboplatin/paclitaxel (C + P) chemotherapy ...
Tópico(s): Immune Response and Inflammation
2019 - BMJ | Journal for ImmunoTherapy of Cancer
... 31S.) " Chronica da Companhia de Jesus " of Father Domingos de Araujo, 1721); from the diary of a ... the Marahão, on the request of Diogo Rodriquez Pereira, captain of the fort of the Rio Negro, ...
1729 - Gale Group | SASII
Produção Nacional
Revisado por pares
Diego Domingos Pereira de Sousa, Camila Ferreira Pinto, Marquele Amorim Tonhela, Ana Cláudia Granato, Artur de Jesus Motheo, Alexandre de Faria Lima, Deusmaque Carneiro Ferreira, David Maikel Fernandes, Ana Luiza de Toledo Fornazari, Geoffroy Roger Pointer Malpass,
Abstract The efficiency of electrolysis (EC/Cl2) and photo-assisted electrolysis (EC/UV/Cl2) methods, in the presence of chloride, for the abatement of real dairy waste from a producer in the Triangulo Mineiro region of Brazil, was evaluated. A complete 23 factorial design was performed for the variables time, pH and current. After determining the ideal pH, a Central Compound Design (CCD) was performed, where the applied current (533.42 mA) and treatment time (60.45 minutes) were maximized. The effluent ...
Tópico(s): Water Quality Monitoring and Analysis
2019 - Pergamon Press | Water Science & Technology
... 31S.) " Chronica da Companhia de Jesus " of Father Domingos de Araujo, 1721); from the diary of a ... the Marahão, on the request of Diogo Rodriquez Pereira, captain of the fort of the Rio Negro, ...
1729 - Gale Group | SASII
Produção Nacional
Revisado por pares
Maria Maiara Cazotti Tanure, Liovando Marciano da Costa, Hugo Alberto Huiz, Raphael Bragança Alves Fernandes, Paulo Roberto Cecon, José Domingos Pereira, José Maria Rodrigues da Luz,
Studies on biochar application in agriculture are broad, but the effects are variable and depend on the type of plant, biochar properties, and application rate, as well as some soil characteristics and environmental conditions. This study aimed to assess the effect of applying different doses of biochar with two particle sizes on the physical and chemical characteristics of a Typic Haplustox, sandy loam, and on the growth and physiological characters of maize plants, under two soil moisture conditions. ...
Tópico(s): Soil and Unsaturated Flow
2019 - Elsevier BV | Soil and Tillage Research
... 31S.) " Chronica da Companhia de Jesus " of Father Domingos de Araujo, 1721); from the diary of a ... the Marahão, on the request of Diogo Rodriquez Pereira, captain of the fort of the Rio Negro, ...
1729 - Gale Group | SASII
Sonia Domingos‐Pereira, Karthik Sathiyanadan, Stefano La Rosa, Lenka Polák, Mathieu F. Chevalier, Paul Martel, Rim Hojeij, Laurent Derré, Jacques‐Antoine Haefliger, Patrice Jichlinski, Denise Nardelli‐Haefliger,
Preclinical data show that intravesical instillation of Ty21a/Vivotif, a commercial vaccine against typhoid fever, is an effective alternative option to standard Bacillus Calmette-Guérin (BCG) immunotherapy for non-muscle-invasive bladder cancer (NMIBC). Here, we characterized the inflammatory effects of Ty21a on the bladder and investigated the immune mechanisms underlying tumor regression toward the use of this bacterial vaccine in NMIBC patients. MB49 bladder tumor-bearing mice had significantly ...
Tópico(s): Immune responses and vaccinations
2019 - American Association for Cancer Research | Cancer Immunology Research
... 31S.) " Chronica da Companhia de Jesus " of Father Domingos de Araujo, 1721); from the diary of a ... the Marahão, on the request of Diogo Rodriquez Pereira, captain of the fort of the Rio Negro, ...
1729 - Gale Group | SASII
Laura Arribillaga, Iciar Echeverria, Viriginia Belsue, Timothy S. Gomez, Teresa Lozano, Noëlia Casares, Lorea Villanueva, Sonia Domingos‐Pereira, Pedro Romero, Denise Nardelli‐Haefliger, Sandra Hervás‐Stubbs, Pablo Sarobe, María Josefa Rodríguez, José L. Carrascosa, Thomas Zürcher, Juan José Lasarte,
Background In vivo targeting of human papillomavirus (HPV) derived antigens to dendritic cells might constitute an efficient immunotherapeutic strategy against cervical cancer. In previous works, we have shown that the extra domain A from murine fibronectin (mEDA) can be used to target antigens to toll-like receptor 4 (TLR4) expressing dendritic cells and induce strong antigen-specific immune responses. In the present study, we have produced a bivalent therapeutic vaccine candidate consisting of the ...
Tópico(s): Virus-based gene therapy research
2020 - BMJ | Journal for ImmunoTherapy of Cancer
... 31S.) " Chronica da Companhia de Jesus " of Father Domingos de Araujo, 1721); from the diary of a ... the Marahão, on the request of Diogo Rodriquez Pereira, captain of the fort of the Rio Negro, ...
1729 - Gale Group | SASII
Sonia Domingos‐Pereira, Laurent Derré, Loane Warpelin‐Decrausaz, Jacques‐Antoine Haefliger, Pedro Romero, Patrice Jichlinski, Denise Nardelli‐Haefliger,
Vaccines targeting tumor associated antigens are in development for bladder cancer. Most of these cancers are nonmuscle invasive at diagnosis and confined in the mucosa and submucosa. However, to our knowledge how vaccination may induce the regression of tumors at such mucosal sites has not been examined previously. We compared different immunization routes for the ability to induce vaccine specific antitumor CD8 T cells in the bladder and bladder tumor regression in mice.In the absence of a murine ...
Tópico(s): Immune Cell Function and Interaction
2013 - Lippincott Williams & Wilkins | The Journal of Urology
... 31S.) " Chronica da Companhia de Jesus " of Father Domingos de Araujo, 1721); from the diary of a ... the Marahão, on the request of Diogo Rodriquez Pereira, captain of the fort of the Rio Negro, ...
1729 - Gale Group | SASII