Produção Nacional
Revisado por pares
Guilherme Pereira Carlesso, Mariana Helena Barboza Gonçalves, Dorival Moreschi Júnior,
Resumo Contexto O atual envelhecimento da população tem gerado maior predominância de doenças crônicas, como o diabetes, a qual está associada a um risco elevado de complicações crônicas e agudas. Entre essas, o pé diabético (PD) destaca-se por possuir alta incidência e grande poder mutilador. Objetivo Avaliar o conhecimento da população diabética das Unidades Básicas de Saúde (UBS) de Maringá (PR) sobre a prevenção do PD. Métodos Estudo descritivo, quantitativo, tipo inquérito por entrevista. A população ...
Tópico(s): Healthcare during COVID-19 Pandemic
2017 - Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV) | Jornal Vascular Brasileiro
Produção Nacional
Revisado por pares
Dorival Mendes Rodrigues‐Junior, Soon Sim Tan, Luciano de Souza Viana, André Lopes Carvalho, Sai Kiang Lim, N. Gopalakrishna Iyer, André L. Vettore,
There is a paucity of plasma-based biomarkers that prospectively segregate the outcome of patients with head and neck squamous-cell carcinoma (HNSCC) treated with chemoradiation therapy (CRT). Plasma extracellular vesicles (EVs) might be an alternative source for discovery of new specific markers present in patients with HNSCC, which could help to re-direct patients to appropriate curative therapies without delay. In order to identify new markers in plasma compartments, Cholerae toxin B chain (CTB) ...
Tópico(s): Circular RNAs in diseases
2019 - BioMed Central | BMC Cancer
Produção Nacional
Revisado por pares
Dorival Mendes Rodrigues‐Junior, Soon Sim Tan, Sai Kiang Lim, Hui Sun Leong, Matias Eliseo Melendez, Cíntia Regina Niederauer Ramos, Luciano de Souza Viana, Daniel Shao-Weng Tan, André Lopes Carvalho, N. Gopalakrishna Iyer, André L. Vettore,
Abstract Management of locally advanced head and neck squamous cell carcinoma (HNSCC) requires a multi-prong approach comprising surgery, radiation and/or chemotherapy, yet outcomes are limited. This is largely due to a paucity of biomarkers that can predict response to specific treatment modalities. Here, we evaluated TGFβ3 protein levels in extracellular vesicles (EVs) released by HNSCC cells as a predictor for response to chemoradiation therapy (CRT). To this end, specific EV-fractions were isolated ...
Tópico(s): MicroRNA in disease regulation
2019 - Oxford University Press | Carcinogenesis
Dorival Mendes Rodrigues‐Junior, Chrysoula Tsirigoti, Sai Kiang Lim, Carl‐Henrik Heldin, Aristidis Moustakas,
Complexity in mechanisms that drive cancer development and progression is exemplified by the transforming growth factor β (TGF-β) signaling pathway, which suppresses early-stage hyperplasia, yet assists aggressive tumors to achieve metastasis. Of note, several molecules, including mRNAs, non-coding RNAs, and proteins known to be associated with the TGF-β pathway have been reported as constituents in the cargo of extracellular vesicles (EVs). EVs are secreted vesicles delimited by a lipid bilayer and ...
Tópico(s): Cancer-related molecular mechanisms research
2022 - Frontiers Media | Frontiers in Cell and Developmental Biology
Produção Nacional
Revisado por pares
Dorival Mendes Rodrigues‐Junior, Maria Fernanda de Andrade Pelarin, Helena B. Nader, André L. Vettore, Maria Aparecida da Silva Pinhal,
Introduction: Multiple myeloma (MM) remains an incurable disease, and patient survival requires a better understanding of this malignancy's molecular aspects. Heparanase (HPSE) is highly expressed in aggressive MM cells and related to tumor growth, metastasis, and bortezomib (BTZ) resistance. Thus, targeting HPSE seems to be a promising approach for MM treatment, and because microRNAs (miRNAs) have emerged as potential regulators of HPSE expression, the use of extracellular vesicles (EVs) can allow the ...
Tópico(s): MicroRNA in disease regulation
2021 - Dove Medical Press | OncoTargets and Therapy
Panagiotis Papoutsoglou, Dorival Mendes Rodrigues‐Junior, Anita Morén, Andrew Bergman, Fredrik Pontén, Cédric Coulouarn, Laia Caja, Carl‐Henrik Heldin, Aristidis Moustakas,
Abstract Activation of the transforming growth factor β (TGFβ) pathway modulates the expression of genes involved in cell growth arrest, motility, and embryogenesis. An expression screen for long noncoding RNAs indicated that TGFβ induced mir-100-let-7a-2-mir-125b-1 cluster host gene ( MIR100HG ) expression in diverse cancer types, thus confirming an earlier demonstration of TGFβ-mediated transcriptional induction of MIR100HG in pancreatic adenocarcinoma. MIR100HG depletion attenuated TGFβ signaling, ...
Tópico(s): RNA Research and Splicing
2021 - Springer Nature | Oncogene
Produção Nacional
Revisado por pares
Alessandro E.C. Granato, Edgar Ferreira da Cruz, Dorival Mendes Rodrigues‐Junior, Amanda Cristina Mosini, Henning Ulrich, Bruno V. M. Rodrigues, Arquimedes Cheffer, Marimélia Porcionatto,
Scaffolds composed of extracellular matrix (ECM) can assist tissue remodeling and repair following injury. The ECM is a complex biomaterial composed of proteins, glycoproteins, proteoglycans, and glycosaminoglycans, secreted by cells. The ECM contains fundamental biological cues that modulate cell behavior and serves as a structural scaffold for cell adhesion and growth. For clinical applications, where immune rejection is a constraint, ECM can be processed using decellularization methods intended ...
Tópico(s): Bone Tissue Engineering Materials
2020 - Elsevier BV | Tissue and Cell
Maria Peleli, Ivi Antoniadou, Dorival Mendes Rodrigues‐Junior, Odysseia Savvoulidou, Laia Caja, Antonia Katsouda, Daniel F.J. Ketelhuth, Jane Stubbe, Kirsten Madsen, Aristidis Moustakas, Andreas Papapetropoulos,
Glioblastoma (GBM) is the most common type of adult brain tumor with extremely poor survival. Cystathionine-gamma lyase (CTH) is one of the main Hydrogen Sulfide (H2S) producing enzymes and its expression contributes to tumorigenesis and angiogenesis but its role in glioblastoma development remains poorly understood. and Principal Results: An established allogenic immunocompetent in vivo GBM model was used in C57BL/6J WT and CTH KO mice where the tumor volume and tumor microvessel density were blindly ...
Tópico(s): Folate and B Vitamins Research
2023 - Elsevier BV | Redox Biology
Produção Nacional
José Eduardo Pitelli Turco, Dilermano Perecin, Dorival Leão Pinto Júnior,
INFLUÊNCIA DA ACURÁCIA DE INSTRUMENTOS DE MEDIDAS NA COMPARAÇÃO DE MÉTODOS DE ESTIMATIVA DA EVAPOTRANSPIRAÇÃO DE REFERÊNCIA José Eduardo Pitelli Turco1; Dilermando Perecin2; Dorival Leão Pinto Jr31Departamento de Engenharia Rural, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP, jepturco@fcav.unesp.br2Departamento de Ciências Exatas, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista, Jaboticabal, SP3Instituto de Ciências ...
Tópico(s): Leaf Properties and Growth Measurement
2008 - UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO | Irriga
Laia Caja, Mahsa Shahidi Dadras, Artur Mezheyeuski, Dorival Mendes Rodrigues‐Junior, Sijia Liu, Anna Webb, Maria Catalina Gomez‐Puerto, Peter ten Dijke, Carl‐Henrik Heldin, Aristidis Moustakas,
Abstract The role of liver kinase B1 (LKB1) in glioblastoma (GBM) development remains poorly understood. LKB1 may regulate GBM cell metabolism and has been suggested to promote glioma invasiveness. After analyzing LKB1 expression in GBM patient mRNA databases and in tumor tissue via multiparametric immunohistochemistry, we observed that LKB1 was localized and enriched in GBM tumor cells that co‐expressed SOX2 and NESTIN stemness markers. Thus, LKB1‐specific immunohistochemistry can potentially reveal ...
Tópico(s): FOXO transcription factor regulation
2021 - Wiley | Journal of Cellular Physiology
Produção Nacional
Alessandro E.C. Granato, Bruno V. M. Rodrigues, Dorival Mendes Rodrigues‐Junior, Fernanda Roberta Marciano, Anderson Oliveira Lobo, Marimélia Porcionatto,
Among nanostructured materials, multi-walled carbon nanotubes (MWCNT) have demonstrated great potential for biomedical applications in recent years. After oxygen plasma etching, we can obtain super-hydrophilic MWCNT that contain graphene oxide (GO) at their tips. This material exhibits good dispersion in biological systems due to the presence of polar groups and its excellent magnetic properties due to metal particle residues from the catalyst that often remain trapped in its walls and tips. Here, ...
Tópico(s): Bone Tissue Engineering Materials
2016 - Elsevier BV | Materials Science and Engineering C
Produção Nacional
Revisado por pares
Luiza Zainotti Miguel Fahur Bottino, Dorival Mendes Rodrigues‐Junior, Ingrid Sancho de Farias, Laura Migliari Branco, N. Gopalakrishna Iyer, Gabriela Estrela de Albuquerque, André L. Vettore, Karina Ramalho Bortoluci,
The content of tumor-derived extracellular vesicles (EVs) can regulate the tumor microenvironment and functionally acts in favor of cancer aggressiveness. To better elucidate the role of EVs in the interplay between immune system and tumor microenvironment, the purpose of this study was to analyze the effect of head and neck squamous cells carcinoma (HNSCC)-derived EVs on the modulation of inflammasomes - mediators of pyroptosis and secretion of inflammatory factors by macrophages. Our results showed ...
Tópico(s): Biomarkers in Disease Mechanisms
2021 - Elsevier BV | Current Research in Immunology
Produção Nacional
Dorival Mendes Rodrigues‐Junior, Tha�s Biassi, Gabriela Estrela de Albuquerque, Viviane Carlin, Marcus V. Buri, Joel Machado, André L. Vettore,
Multiple myeloma (MM) is an incurable disease; a better understanding of the molecular aspects of this hematological malignancy could contribute to the development of new treatment strategies and help to improve the survival rates of patients with MM. Previously, the methylation status of the deleted in colorectal cancer (DCC) gene was correlated with the survival rate of patients with MM, thus the main goal of this study was to understand DCC contribution to MM tumorigenesis, and to assess the impact ...
Tópico(s): Drug Transport and Resistance Mechanisms
2019 - Spandidos Publishing | Molecular Medicine Reports
Produção Nacional
Revisado por pares
Dorival Mendes Rodrigues‐Junior, Nicolie Melanie de Almeida Pontes, Gabriela Estrela de Albuquerque, Viviane Carlin, Givago P. Perecim, Cristiano Raminelli, André Luiz Vettore,
Tópico(s): Agricultural pest management studies
2019 - Springer Science+Business Media | Investigational New Drugs
Produção Nacional
Revisado por pares
Dorival Mendes Rodrigues‐Junior, Alesse Ribeiro dos Santos, Ana Amélia de Carvalho Melo Cavalcante, Airlane Pereira Alencar, Pedro Vitor Lopes‐Costa, Benedito Borges da Silva,
Abstract The aim of this study was to evaluate micronucleus (MN) frequency in polychromatic erythrocytes (PCE) of female rats in persistent estrus (a model developed to mimic polycystic ovary syndrome) treated with selective estrogen receptor modulators (SERMs, tamoxifen, and raloxifene). Forty female Wistar‐Hannover rats were divided into four groups of 10 animals each: Group I (normally cycling rats) and Group II (persistent estrus) both received only vehicle, while Group III (persistent estrus) was ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2011 - Wiley | Environmental and Molecular Mutagenesis
Produção Nacional
Revisado por pares
Vinícius Veloso de Melo, Alexandre C. B. Delbem, Dorival Leão Pinto Júnior, Fernando Marques Federson,
We have developed an algorithm using a Design of Experiments technique for reduction of search-space in global optimization problems. Our approach is called Domain Optimization Algorithm. This approach can efficiently eliminate search-space regions with low probability of containing a global optimum. The Domain Optimization Algorithm approach is based on eliminating non-promising search-space regions, which are identifyed using simple models (linear) fitted to the data. Then, we run a global optimization ...
Tópico(s): Evolutionary Algorithms and Applications
2007 - Springer Science+Business Media | Lecture notes in computer science
Produção Nacional
Revisado por pares
Henrique Arruda Soares, Dorival Fontanello, J Mandelli-junior, Janaína Maria Silva dos Reis, L. A. Penteado,
Estudou-se o efeito de 4 densidades de populacao 1, 5, 10 e 15 animais/litro sobre o ganho de peso de girinos da ra-touro (Rana catesbeiana Shaw, 1802), em condicoes de campo (ranario). Foi concluido que o aumento da densidade de girinos retarda o ganho de peso. Este efeito pode ser calculado pela equacao Y = 8,096 - 0,8201 X + 0,02504 X2, onde X representa a densidade (girinos/litro) e Y o ganho de peso, medio, de girinos, para os limites estudados.
Tópico(s): Animal Nutrition and Physiology
1983 - INSTITUTO DE PESCA - APTA - SEC. DE AGR. E ABAST. - SP | Boletim do Instituto de Pesca
Produção Nacional
Revisado por pares
Dorival Mendes Rodrigues‐Junior, Soon Sim Tan, Sai Kiang Lim, Luciano de Souza Viana, André Lopes Carvalho, André Luiz Vettore, N. Gopalakrishna Iyer,
Background There is a paucity of plasma‐based biomarkers that predict outcome in patients with head and neck squamous cell carcinoma (HNSCC) treated with chemoradiation therapy (CRT). Here, we evaluate the prognostic potential of plasma Melanoma‐Antigen Recognized by T‐cells 1 (MLANA) in this setting. Methods MLANA expression in HNSCC lines were evaluated by reverse transcription polymerase chain reaction, whereas plasma levels were quantified using ELISA in 48 patients with locally advanced HNSCC ...
Tópico(s): Ear and Head Tumors
2019 - Wiley | Head & Neck
Produção Nacional
Revisado por pares
Dorival Mendes Rodrigues‐Junior, Thaís Priscila Biassi, Viviane Carlin, Marcus V. Buri, Ana Cláudia Torrecilhas, Karina Ramalho Bortoluci, André L. Vettore,
Tópico(s): Nanoplatforms for cancer theranostics
2018 - Springer Science+Business Media | Journal of Molecular Neuroscience
Dorival Mendes Rodrigues‐Junior, Aristidis Moustakas,
Deeper analysis of molecular mechanisms arising in tumor cells is an unmet need to provide new diagnostic and therapeutic strategies to prevent and treat tumors. The transforming growth factor β (TGF-β) signaling has been steadily featured in tumor biology and linked to poor prognosis of cancer patients. One pro-tumorigenic mechanism induced by TGF-β is the epithelial-to-mesenchymal transition (EMT), which can initiate cancer dissemination, enrich the tumor stem cell population, and increase chemoresistance. ...
Tópico(s): Mycobacterium research and diagnosis
2024 - Taylor & Francis | Upsala Journal of Medical Sciences
Produção Nacional
Revisado por pares
Danylo Rafhael Costa-Silva, Maria da Conceição Barros-Oliveira, Francisco Adelton Alves Ribeiro, Larysse Cardoso Campos-Verdes, Elmo de Jesus Nery, Samara Fernanda Vieira-Valença, Rodrigo José de Vasconcelos-Valença, V. Soares, André Luiz Pinho-Sobral, Emerson Brandão Sousa, Pedro Vitor Lopes‐Costa, Alesse Ribeiro dos Santos, Jackeline Lopes Viana, Arquimedes Cavalcante Cardoso, Victoria Maria Luz-Borges, Renato de Oliveira Pereira, Cléciton Braga Tavares, Vladimir Costa Silva, Dorival Mendes Rodrigues‐Junior, Luíz Henrique Gebrim, Benedito Borges da Silva,
Breast cancer is the most common malignancy affecting women worldwide. The insulin-like growth factor 1 (IGF-1) gene encodes a protein responsible for a wide variety of physiological processes, including differentiation and cell proliferation. Despite several studies on tumor tissues, no study has evaluated IGF-1 expression in the peripheral blood of women with recurrent breast cancer.In this cross-sectional study, IGF-1 expression in the peripheral blood of 146 women with breast cancer treated approximately ...
Tópico(s): Cancer Cells and Metastasis
2020 - Wolters Kluwer | Medicine
Dorival Mendes Rodrigues‐Junior, Chrysoula Tsirigoti, Konstantina Psatha, Dimitris Kletsas, Michalis Aivaliotis, Carl-Henrik Heldin, Aristidis Moustakas,
Tópico(s): MicroRNA in disease regulation
2025 - BioMed Central | Journal of Experimental & Clinical Cancer Research
Produção Nacional
Revisado por pares
Mariana Teixeira Rodrigues, Ana Paula Picaro Michelli, Gustavo Felisola Caso, Paloma Ramos de Oliveira, Dorival Mendes Rodrigues‐Junior, Mirian Galliote Morale, Joel Machado, Karina Ramalho Bortoluci, Rodrigo Esaki Tamura, Tamiris Reissa Cipriano da Silva, Cristiano Raminelli, Eric Chau, Biana Godin, Jamile Calil‐Silveira, Ileana Gabriela Sanchez Rubio,
Anaplastic thyroid cancer (ATC) is an aggressive form of thyroid cancer (TC), accounting for 50% of total TC-related deaths. Although therapeutic approaches against TC have improved in recent years, the survival rate remains low, and severe adverse effects are commonly reported. However, unexplored alternatives based on natural compounds, such as lysicamine, an alkaloid found in plants with established cytotoxicity against breast and liver cancers, offer promise. Therefore, this study aimed to explore ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2023 - Multidisciplinary Digital Publishing Institute | Pharmaceuticals
Produção Nacional
Revisado por pares
Dorival Mendes Rodrigues‐Junior, Cristiano Raminelli, Haifa Hassanie, Gustavo Henrique Goulart Trossini, Givago P. Perecim, Laia Caja, Aristidis Moustakas, André L. Vettore,
Abstract Glioblastoma (GBM) is the most aggressive and common primary malignant brain tumor with limited available therapeutic approaches. Despite improvements in therapeutic options for GBM patients, efforts to develop new successful strategies remain as major unmet medical needs. Based on the cytotoxic properties of aporphine compounds, we evaluated the biological effect of 12 compounds obtained through total synthesis of ( ±)-apomorphine hydrochloride (APO) against GBM cells. The compounds 2,2,2-trifluoro- ...
Tópico(s): Histone Deacetylase Inhibitors Research
2022 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Reiko Aoki, Dorival Leão Pinto Júnior, Jorge Alberto Achcar, Heleno Bolfarine,
In this paper we propose the use of a multivariate null intercept measurement error model, where the true unobserved value of the covariate follows a mixture of two normal distributions. The proposed model is applied to a dental clinical trial presented in Hadgu and Koch (1999). A Bayesian approach is considered and a Gibbs Sampler is used to perform the computations.
Tópico(s): Bayesian Methods and Mixture Models
2006 - Taylor & Francis | Journal of Biopharmaceutical Statistics
Produção Nacional
Revisado por pares
Dorival Mendes Rodrigues‐Junior, Soon Sim Tan, Sai Kiang Lim, N. Gopalakrishna Iyer, André L. Vettore,
... or not to IC or CRT. Citation Format: Dorival Mendes Rodrigues-Junior, Soon Sim Tan, Sai Kiang Lim, N Gopalakrishna ...
Tópico(s): Nanoplatforms for cancer theranostics
2016 - American Association for Cancer Research | Cancer Research
Produção Nacional
Revisado por pares
Viviane Carlin, Dorival Mendes Rodrigues‐Junior, Thaís Priscila Biassi, Bruno Heidi Nakano Nozima, Marcus V. Buri, André L. Vettore,
... in the HNSCC carcinogenesis. Citation Format: Viviane Carlin, Dorival Mendes Rodrigues-Junior, Thais Priscila Biassi, Bruno Heidi Nakano Nozima, Marcus ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2015 - American Association for Cancer Research | Cancer Research
Produção Nacional
Revisado por pares
Dorival Mendes Rodrigues‐Junior, Thais Priscilla Biassi, Viviane Carlin, Joel Machado, André L. Vettore,
... this cell line. Support by FAPESP Citation Format: Dorival Mendes Rodrigues-Junior, Thais Priscilla Biassi, Viviane Carlin, Joel Machado-Junior, ...
Tópico(s): Hematological disorders and diagnostics
2014 - American Association for Cancer Research | Cancer Research
Produção Nacional
Revisado por pares
Vergilius José Furtado de Araújo Filho, Dorival de Carlucci Júnior, Adriana Sondermann, Maria Teresa A. S. Machado, Paulo Campos Carneiro, Alberto Rossetti Ferraz,
OBJETIVO: Avaliar o método de punção biópsia aspirativa por agulha fina (PBAAF), técnica relativamente simples, de conhecida importância em cirurgia de cabeça e pescoço. Sua indicação em doenças das glândulas salivares, no entanto, especialmente na parótida, ainda é muito controversa na literatura. O diagnóstico pela PBAAF permite o adequado planejamento terapêutico e preparo do paciente. Muitos, porém, alegam que seu emprego acrescenta muito pouco à conduta terapêutica, além de ser procedimento ...
Tópico(s): Tumors and Oncological Cases
2001 - Brazilian College of Surgeons | Revista do Colégio Brasileiro de Cirurgiões
Produção Nacional
Revisado por pares
O roteiro deste breve artigo é primeiro lançar algumas luzes sobre o conceito de Patriotismo Constitucional, que se tornou conhecido após o seu uso por Jürgen Habermas, apresentando um breve aspecto histórico do mesmo, a partir da sua formação. Posteriormente apresentam-se duas posições revisitadas do Patriotismo, de Arroyo e de Maia, que trazem interessantes discussões ao debate em outros países que não a Alemanha, sob um enfoque mais republicanistas (Republicanismo) do que o próprio Habermas. Em ...
Tópico(s): Comparative constitutional jurisprudence studies
2018 - UNIVERSIDADE FEDERAL RURAL DO SEMI-ARIDO | Revista Jurídica da UFERSA