Single intramuscular doses of fentanyl, droperidol, fentanyl plus droperidol, morphine, and placebo were compared in a double‐blind, cross‐over study on 6 normal male postnarcotic addicts. ... as morphine. In the combination of fentanyl plus droperidol, droperidol alters some of the morphinelike effects of the mixture, making the mixture similar to droperidol alone. However, if the dose of fentanyl in ... or fentanyl alone. The time courses of fentanyl, droperidol, and fentanyl plus droperidol are similar and differ ...
Tópico(s): Chemical synthesis and alkaloids
1965 - Wiley | Clinical Pharmacology & Therapeutics
Casimir A. Janicki, Ronald J. Brenner, Barbara E. Schwartz,
In acid solution, droperidol, 1-{1-[3-(p-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl}-2-benzimidazolinone, is decomposed to form ... 1-(2-phenylethyl)piperidine. A procedure to assay droperidol in the presence of its hydrolysis products, fentanyl, and its hydrolysis product is given. Droperidol is analyzed by its UV absorption after being ... fentanyl in the presence of its hydrolysis products, droperidol, and its hydrolysis products is given. Droperidol and 4-anilino-1-(2-phenylethyl)-piperidine are ...
Tópico(s): Pharmacy and Medical Practices
1968 - Elsevier BV | Journal of Pharmaceutical Sciences
William A. Cressman, Janis Plostnieks, P. C. Johnson,
The absorption, metabolism and excretion of droperidol, a neuroleptic agent, was studied in human subjects following intramuscular and intravenous administration of droperido-3PH. Plasma, urinary and fecal levels of droperidol and total radioactivity were measured. Droperidol was rapidly absorbed following intramuscular administration. The plasma-level profiles of droperidol showed characteristic two-compartment open-model kinetics. The ... quite rapid, T1/3=10 minutes. In addition, droperidol was eliminated from the plasma at very similar ...
Tópico(s): Phosphodiesterase function and regulation
1973 - Lippincott Williams & Wilkins | Anesthesiology
... anaesthesia were given 0.014 mg/kg of droperidol or a saline placebo i. v. in a ... postoperative nausea and vomiting. Overall, less patients given droperidol were nauseated (18%) or vomited (7%) in comparison ... the first postoperative hour, 4% of patients given droperidol were nauseated and 2% vomited, whereas 16% of ... significantly ( P <0.001) worse in patients given droperidol as compared to patients given saline. After 60 min, only one patient given droperidol and four patients who received saline and vomited ...
Tópico(s): Anesthesia and Sedative Agents
1985 - Wiley | Acta Anaesthesiologica Scandinavica
Koji Sumikawa, Hideki Hirano, Y Amakata, Takeshi Kashimoto, Akihiko Wada, Futoshi Izumi,
The study was undertaken to determine whether droperidol had an effect to induce catecholamine efflux from the adrenal medulla as a mechanism for the possible pressor effect of droperidol in patients with pheochromocytoma and, if so, to ... 0.66 micrograms/min by the administration of droperidol 6.6 microM. This effect of droperidol was not dependent on extracellular Ca++, in contrast ... observed in response to acetylcholine and caffeine. However, droperidol-, histamine-, and reserpine-induced catecholamine efflux was not ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
1985 - Lippincott Williams & Wilkins | Anesthesiology
Christian C. Apfel, Özlem Serpil Çakmakkaya, G. Frings, Peter Kranke, A K Malhotra, A. Stader, Alparslan Turan, A. Biedler, Kerstin Kolodzie,
... to a factorial design, one of which was droperidol 1.25 mg vs placebo. We considered differences ... in the control to 32.0% in the droperidol group, corresponding to a relative risk (RR) of ... In the early postoperative period (0–2 h), droperidol prevented nausea and vomiting similarly, with an RR ... with the early postoperative period.ConclusionsWe conclude that droperidol prevents PON and POV equally well, yet its duration of action is short-lived. Droperidol is commonly noted to be more effective at ... to a factorial design, one of which was droperidol 1.25 mg vs placebo. We considered differences ...
Tópico(s): Anesthesia and Sedative Agents
2009 - Elsevier BV | British Journal of Anaesthesia
Droperidol, a butyrophenone derivative and dopamine D2 receptor antagonist, was developed in the 1950s as an antipsychotic ... for neurolept anaesthesia and as an anti-emetic. Droperidol acts centrally at sites where dopamine, norepinephrine and ... vomiting [1]. Since the late 1970s, low-dose droperidol (0.625–1.25 mg) has been widely ... treat PONV in adults and children [2, 3]. Droperidol was withdrawn from clinical use in 2001 but ... QT prolongation were linked to the use of droperidol. Due to the accumulating evidence of QT prolongation ...
Tópico(s): Pathogenesis and Treatment of Hiccups
2009 - Wiley | Anaesthesia
J Weissenburger, Christian Funck‐Brentano, Patrice Jaillon, Bény Charbit,
Droperidol and ondansetron are potent anti-emetic agents which are often administered together. Although both drugs prolong ... go-go Related Gene-coded potassium channels, only droperidol was tested using more integrated experimental models. Therefore, ... concentrations (from 0.001 to 10 microm) of droperidol (n = 7) or ondansetron (n = 8) at 30 ... C. Other fibers were exposed to a constant droperidol concentration (0.1 microm) alone (n = 7) or ... the same increasing concentrations of ondansetron (n = 6). Droperidol increased AP duration measured at 90% repolarization (APD90) ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2009 - Wiley | Fundamental and Clinical Pharmacology
Massin Lebitasy, Jean‐Daniel Hecq, Danielle Vanbeckbergen, Jacques Jamart, Laurence Galanti,
... stability of tramadol hydrochloride 100 mg associated with droperidol 2.5 mg in 100 ml of 5% ... containing approximately tramadol hydrochloride 100 mg associated with droperidol 2.5 mg were prepared under aseptic conditions ... at 5 ± 3 °C. The tramadol hydrochloride and droperidol concentrations were measured by high performance liquid chromatography ( ... was observed. Tramadol hydrochloride 100 mg associated with droperidol 2.5 mg in 100 ml of 5% ... this study, tramadol hydrochloride 100 mg associated with droperidol 2.5 mg in100 ml of 5% dextrose ...
Tópico(s): Anesthesia and Pain Management
2009 - Elsevier BV | Annales Pharmaceutiques Françaises
Brown Re, Daniel J. James, Richard G. Weaver, Randall D. Wilhoit, Loren A. Bauman,
... Objective: To determine whether a low dose of droperidol is as effective as a high dose in ... divided randomly into three groups and received either droperidol 75 μg/kg, droperidol 20 μg/kg, or saline. Measurements and Main ... a satisfactory postoperative eye examination. Children who received droperidol vomited less frequently than those who did not ( ... of vomiting between the two groups that received droperidol. Conclusions: Droperidol 20 μg/kg is as effective as droperidol 75 μg/kg in preventing vomiting after pediatric ...
Tópico(s): Intraocular Surgery and Lenses
1991 - Elsevier BV | Journal of Clinical Anesthesia
Background Droperidol is used in neuroleptanesthesia and as an antiemetic. Although its antiemetic effect is thought to be caused by dopaminergic inhibition, the mechanism of droperidol's anesthetic action is unknown. Because gamma-aminobutyric ... anesthetic drugs, the authors tested the ability of droperidol to modulate these receptors. Methods gamma-Aminobutyric acid ... clamp recording. The authors tested the ability of droperidol at concentrations from 1 nm to 100 microm ... of these receptors by their native agonists. Results Droperidol inhibited the GABA response by a maximum of ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
2002 - Lippincott Williams & Wilkins | Anesthesiology
Ken Nakata, Tadanori Mammoto, Takashi Kita, Hiroshi Taniguchi, Noriko Kanbara, Tetsuya Akamatsu, Toshiko Sakai, Yoshihiko Kishi,
Purpose: To investigate whether continuous epidural droperidol and intravenous (IV) intraoperative droperidol inhibit pruritus and postoperative nausea and vomiting (PONV) during epidural morphine analgesia. Design: Randomized, double-blinded, controlled ... group, Group B = intraoperative single IV injection of droperidol (2.5 mg), Group C = postoperative continuous epidural droperidol infusion (2.5 mg/day), and Group D = intraoperative IV injection of droperidol (2.5 mg) and postoperative continuous epidural droperidol ...
Tópico(s): Pain Management and Opioid Use
2002 - Elsevier BV | Journal of Clinical Anesthesia
Droperidol is a butyrophenone that was approved by the U.S. Food and Drug Administration (FDA) for ... that the manufacturer of the generic formulation of droperidol (Akorn Pharmaceuticals, Buffalo Grove, IL) place a “Black ... TdP]) and even death after small doses of droperidol. The FDA refused to meet with Akorn representatives ... not even a single case report documenting that droperidol caused a cardiac arrhythmia. This is even more remarkable because droperidol is typically administered to surgical patients being continuously ...
Tópico(s): Anesthesia and Pain Management
2002 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
Droperidol is a butyrophenone that was approved by the U.S. Food and Drug Administration (FDA) for ... that the manufacturer of the generic formulation of droperidol (Akorn Pharmaceuticals, Buffalo Grove, IL) place a “Black ... TdP]) and even death after small doses of droperidol. The FDA refused to meet with Akorn representatives ... not even a single case report documenting that droperidol caused a cardiac arrhythmia. This is even more remarkable because droperidol is typically administered to surgical patients being continuously ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2002 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
Peter L. Bailey, Russell Norton, Suzanne Karan,
... Administration (FDA) issued a "black box" warning that droperidol, even at low doses, could cause QT prolongation ... significant cardiac morbidity and mortality was associated with droperidol. The intent and/or the effect of the warning will be to markedly restrict droperidol use. We know of several hospitals that have ... Act, we received information about and analyzed the droperidol cases upon which the FDA warning was based. ... were 89 deaths reported, but the dose of droperidol was 2.5 mg or less in just ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2002 - Lippincott Williams & Wilkins | Anesthesiology
D. Song, Frances Chung, S. Yogendran, Jean Wong,
BackgroundLow‐dose droperidol is suggested to be cost‐effective in preventing nausea and vomiting after ambulatory surgery. This clinical study evaluated ... force platform after an i.v. dose of droperidol 0.625 mg in outpatients undergoing gynaecological dilatation ... to receive either 0.9% saline (placebo) or droperidol 0.625 mg i.v. before surgery. Anaesthesia ... 9, body sway was significantly greater in the droperidol group than in the placebo group (overall 61% ... drowsiness and dizziness. Three patients (5%) in the droperidol group reported nervousness and restlessness postoperatively (not significant). ...
Tópico(s): Sympathectomy and Hyperhidrosis Treatments
2002 - Elsevier BV | British Journal of Anaesthesia
Tong J. Gan, Paul F. White, Philip Scuderi, Mehernoor F. Watcha, Anthony L. Kovac,
... FDA) issued a new "black box" warning on droperidol (Akorn Pharmaceuticals, Buffalo Grove, IL), a popular antiemetic ... or prevention of postoperative nausea and vomiting (PONV). *Droperidol previously carried a warning regarding the potential for ... revised warning suggests that even low doses of droperidol should only be used when other "first-line" ... insert recommendation for this commonly used antiemetic drug.Droperidol has been used for the management of PONV ... of PONV. 2,3In a recent market survey, droperidol constituted over 30% of the antiemetic market share ...
Tópico(s): Nausea and vomiting management
2002 - Lippincott Williams & Wilkins | Anesthesiology
... Therapeutics Products Directorate regarding the arrhythmogenic potential of droperidol have resulted in many hospitals deleting this antiemetic ... significant cardiac morbidity and mortality are associated with droperidol, and that even low doses of the drug ... line” drugs fail. 2 The warnings that injectable droperidol should only be used in the hospital setting ... limited and circumstantial evidence which led to the droperidol directives. The droperidol warnings arose from reports that this drug causes ...
Tópico(s): Anesthesia and Pain Management
2003 - Springer Science+Business Media | Canadian Journal of Anesthesia/Journal canadien d anesthésie
Xavier Culebras, Jean-Baptiste Corpataux, Giovanni Gaggero, Martin R. Tram r,
The antiemetic dose response of droperidol when it is added to patient-controlled analgesia with morphine is not well known. We randomly allocated adults who received postoperative ... min lockout) to one of four regimens: no droperidol (control) or 5, 15, or 50 micro g of droperidol per milligram of morphine. Efficacy and adverse effects ... intervals. Data from 82 controls, 82 patients receiving droperidol 5 micro g, 82 receiving droperidol 15 micro g, and 83 receiving droperidol 50 micro g were analyzed. Average consumption of ...
Tópico(s): Pain Management and Opioid Use
2003 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
Evan L. Fogel, Stuart Sherman, Lois Bucksot, LeeAnn Shelly, Glen A. Lehman,
... and requires that the patient be well sedated. Droperidol is frequently administered when adequate sedation cannot be ... and meperidine. This study examined the effects of droperidol on the biliary and pancreatic sphincters.A total ... meperidine. Manometry was then repeated 5 minutes after droperidol was administered.The basal pressure of the biliary ... the pancreatic sphincter were not significantly altered by droperidol. Concordance (normal vs. abnormal) between the basal sphincter pressure before and after droperidol was seen in 30 patients (97%). Droperidol also ...
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
2003 - Elsevier BV | Gastrointestinal Endoscopy
John H. Shale, Christopher M. Shale, William D. Mastin,
Article AbstractBackground: Droperidol had become a standard treatment for sedating severely agitated or violent patients in both psychiatric and medical emergency departments. However, several recent articles have suggested that droperidol may have a quinidine-like effect similar to ... of thioridazine, the authors reviewed the literature regarding droperidol and dysrhythmia in a MEDLINE search for the years 1960-2002 using the search terms droperidol, dysrhythmia, QTc interval, and sudden death as well ...
Tópico(s): Healthcare Technology and Patient Monitoring
2003 - Physicians Postgraduate Press, Inc. | The Journal of Clinical Psychiatry
C. Mel Wilcox, Jeffrey D. Linder,
Background Droperidol increasingly is used as an effective adjunct for conscious sedation during endoscopic procedures. Given the concern for ... in sedating patients undergoing sphincter of Oddi manometry, droperidol could be an ideal agent in this setting. ... the initial two pull-throughs, 5 mg of droperidol were given intravenously and measurements were repeated 5 ... pressures measured in 35 patients before and after droperidol were, respectively, 56 mm Hg and 48 mm ... pressures measured in 22 patients before and after droperidol were, respectively, 92 mm Hg and 67 mm ...
Tópico(s): Anesthesia and Sedative Agents
2003 - Elsevier BV | Gastrointestinal Endoscopy
Peter L. Bailey, Paul F. White,
... by Dr. Scuderi in his recent editorial entitled "Droperidol: Many questions, few answers."1Dr. Scuderi rightfully points ... and Drug Administration (FDA) "black box" warning on droperidol may "overshadow" many other important issues involving the ... that many clinicians are now reluctant to use droperidol because of medicolegal concerns, despite its long and ... record. The FDA-imposed black box warning on droperidol has rendered the results of numerous, placebo-controlled, ... the database summarizing the "reported" adverse events with droperidol is seriously flawed. 2Furthermore, it is unclear whether ...
Tópico(s): Pharmacovigilance and Adverse Drug Reactions
2003 - Lippincott Williams & Wilkins | Anesthesiology
Ashraf S. Habib, and Tong J. Gan,
... was suggested that the use of small-dose droperidol has been a highly cost-effective antiemetic for over 30 years. Droperidol, 0.625–1.25 mg IV, has been ... a "black box" warning regarding the use of droperidol for the treatment and/or prevention of PONV ... adverse events were reported after the use of droperidol at doses of 1.25 mg or less. ... health care professionals. The reporting person determined whether droperidol was the primary or secondary suspect. The content ... Serious Cardiac Adverse Events or Death Associated with Droperidol at Doses of 1.25 mg or LessDiscussion ...
Tópico(s): Anesthesia and Sedative Agents
2003 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
... the cases on which the FDA warning on droperidol was based, Habib and Gan (1) used 1. ... threshold dose and reported 10 cases in which droperidol supposedly caused a severe adverse cardiac event. In ... 19 cases in the FDA database alleging severe droperidol-induced cardiac toxicity. Even when the more liberal ... the described events. There is no doubt that droperidol at larger doses can cause severe arrhythmias. In ... emergency department of a European hospital, are given droperidol at doses of 25–100 mg, and are ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2003 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
... to a prophylactic regimen of 0.625 mg droperidol and 4 mg dexamethasone did not result in ... by a concern as to the safety of droperidol, even in low doses. As the authors note, ... called “black box” warning regarding the use of droperidol for antiemetic prophylaxis (FDA Strengthens Warnings for Droperidol. Available on the web at:http://www.fda. ... than either 0.625 or 1.25 mg droperidol in preventing either postoperative nausea or vomiting. 3The ... antiemetic prophylaxis in the ambulatory setting when a droperidol-dexamethasone combination is used.” However, reluctance on the ...
Tópico(s): Anesthesia and Sedative Agents
2003 - Lippincott Williams & Wilkins | Anesthesiology
Phillip Barrow, David G. Hughes, Nancy Redfern, J. URIE,
We have studied the addition of droperidol to morphine during patient-controlled analgesia (PCA) in 57 patients using PCA after abdominal hysterectomy. Patients in group 1 (control group) received ... PCA containing morphine; those in group 2 received droperidol 1.25 mg and a PCA containing morphine and those in group 3 droperidol and a PCA containing droperidol 0.05 mg mg-1 of morphine. Patients ... episodes of nausea compared with 35 in the droperidol bolus group and 18 in the droperidol PCA group (P < 0.01). In the droperidol ...
Tópico(s): Pharmacology and Obesity Treatment
1994 - Elsevier BV | British Journal of Anaesthesia
Chandler Hill, James R. Miner, Marc L. Martel,
... treated with either intramuscular (IM) olanzapine or IM droperidol.This was a prospective, randomized nonblinded clinical trial ... headache. Consenting patients were randomized to receive either droperidol 5 mg IM or olanzapine 10 mg IM. ... administration of the study medication, 8 in the droperidol group and 5 in the olanzapine group, leaving 87 patients for analysis. Forty-two patients received droperidol and 45 received olanzapine. In the droperidol group, 35/40 (87.5%) patients who had ... was -37% (95% CI = -84% to 11%) for droperidol and -37% (95% CI = -64% to 10%) for ...
Tópico(s): Nausea and vomiting management
2008 - Wiley | Academic Emergency Medicine
Bény Charbit, Jean‐Claude Alvarez, Eric Dasque, Emuri Abé, Jean Louis Démolis, Christian Funck‐Brentano,
Background Droperidol and ondansetron have previously been found to prolong the QT interval in the treatment of postoperative nausea ... The objective was to study the effects of droperidol and ondansetron alone or in combination on QT ... randomized, placebo-controlled study. Subjects received 1 mg droperidol, 4 mg ondansetron, 1 mg droperidol plus 4 mg ondansetron, or a placebo, intravenously ... QTcF prolongation (DeltaDeltaQTcF). Results Compared with placebo, both droperidol and ondansetron significantly prolonged the QTcF interval. DeltaDeltaQTcF ...
Tópico(s): Anesthesia and Sedative Agents
2008 - Lippincott Williams & Wilkins | Anesthesiology
Danielle Ludwin, Steven L. Shafer,
Anesthesiologists have used droperidol off-label for the last 30 yr for the prevention and treatment of postoperative nausea and vomiting. In 2001, a “black box” warning was added to the droperidol package insert due to concerns of prolonged QT ... added the black box warning, the use of droperidol by anesthesiologists has dramatically diminished.1 In our ... respect to doses below those approved in the droperidol package insert. In June 1968, McNeil laboratories submitted a new drug application for droperidol to the FDA. The drug was approved on ...
Tópico(s): Pharmacy and Medical Practices
2008 - Lippincott Williams & Wilkins | Anesthesia & Analgesia