Pîlar Aranda, Eduardo Ruiz‐Hitzky,
... RETURN TO ISSUEPREVArticleNEXTPoly(ethylene oxide)-silicate intercalation materialsPilar Aranda and Eduardo Ruiz-HitzkyCite this: Chem. Mater. 1992, 4, 6, ...
Tópico(s): Polymer Nanocomposites and Properties
1992 - American Chemical Society | Chemistry of Materials
Eduardo Collantes‐Estévez, M V Blazquez, V. Mazorra, Antonio Macho, Enrique Aranda, Eduardo Muñóz,
OBJECTIVE The NF-κB/Rel family of transcription factors regulates the expression of many genes involved in the immune or inflammatory response at the transcriptional level. The aim of this study was to determine whether distinctive patterns of NF-kB activation are seen in different forms of joint disease. METHODS The DNA binding activity of these nucleoproteins was examined in purified synovial and peripheral T cells from patients with various chronic rheumatic diseases (12: four with rheumatoid arthritis; ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
1998 - BMJ | Annals of the Rheumatic Diseases
Produção Nacional
Revisado por pares
Yodalgis Mosqueda Laffita, Eduardo Pérez Cappe, J.L. Arana, E. Longo, Andreas Ríes, M. Cilense, P.A.P. Nascente, Pîlar Aranda, Eduardo Ruiz‐Hitzky,
A preparation method for a new electrode material based on the LiNi0.8Co0.2O2/polyaniline (PANI) composite is reported. This material is prepared by in situ polymerization of aniline in the presence of LiNi0.8Co0.2O2 assisted by ultrasonic irradiation. The materials are characterized by XRD, TG-DTA, FTIR, XPS, SEM-EDX, AFM, nitrogen adsorption (BET surface area) and electrical conductivity measurements. PANI in the emeraldine salt form interacts with metal-oxide particles to assure good connectivity. ...
Tópico(s): Advanced Battery Materials and Technologies
2005 - Elsevier BV | Journal of Solid State Chemistry
Produção Nacional
Revisado por pares
Eduardo Pérez Cappe, Yodalgis Mosqueda Laffita, Ricardo Martínez, Carlos Ricardo Milian Pila, Orlando A. Sánchez, J.A. Varela, Alejandra Hortencia, Éder Carlos Ferreira de Souza, Pîlar Aranda, Eduardo Ruiz‐Hitzky,
PANI–LiNi0.8Co0.2O2 nanocomposite material with improved properties as positive electrode was prepared by a new synthesis method. In a first step, LiNi0.8Co0.2O2 mixed oxide in the form of a fine powder was dispersed in aniline and this suspension was sprayed on the surface of an aqueous solution of HCl and ammonium peroxodisulfate. The resulting PANI–LiNi0.8Co0.2O2 nanocomposite is spontaneously formed by polymerization of the aniline molecules present in the drops together with small particles ...
Tópico(s): Conducting polymers and applications
2008 - Royal Society of Chemistry | Journal of Materials Chemistry
Pîlar Aranda, Eduardo Ruiz‐Hitzky,
Abstract This account discusses on diverse general approaches employed for the preparation of heterostructured materials based on the immobilization of metal oxides and other nanoparticles on sepiolite and palygorskite fibrous clay minerals, showing the many opportunities of application offered by the resulting materials. Various examples from our own experience have been selected to show how sepiolite acts as a convenient nanoplatform for immobilization of diverse type of nanoparticles, such as ...
Tópico(s): Mesoporous Materials and Catalysis
2018 - Wiley | The Chemical Record
Rosa Fernández, Antonio Guillamón, Joselyn Cortés-Cortés, Esther Gómez‐Gil, María Amalia Jácome, Isabel Esteva, MariCruz Almaraz, Mireia Mora, Gloria Aranda, Eduardo Pásaro,
Polymorphisms in sex steroid receptors have been associated with transsexualism. However, published replication studies have yielded inconsistent findings, possibly because of a limited sample size and/or the heterogeneity of the transsexual population with respect to the onset of dysphoria and sexual orientation. We assessed the role of androgen receptor (AR), estrogen receptors alpha (ERα) and beta (ERβ), and aromatase (CYP19A1) in two large and homogeneous transsexual male-to-female (MtF) and female- ...
Tópico(s): Estrogen and related hormone effects
2018 - Elsevier BV | Psychoneuroendocrinology
Cristina Ruiz‐García, F. G. DE LAS HERAS, Miguel Á. Gilarranz, Pîlar Aranda, Eduardo Ruiz‐Hitzky,
The present work introduces a new type of improved catalysts based on sepiolite-carbon nanocomposites anchoring Pd nanoparticles. The nanocomposites are prepared by assembly in aqueous media of graphene nanoplatelets (GNP) and the nanofibrous sepiolite under a sonomechanical treatment. The methodology allows the co-assembly of other nanomaterials such as multiwall carbon nanotubes (MWCNT) and Pd nanoparticles, these last ones in situ generated from PdCl2 and further treatment with NaBH4. The presence ...
Tópico(s): Electrokinetic Soil Remediation Techniques
2018 - Elsevier BV | Applied Clay Science
Jesús García‐Foncillas, Emilio Alba, Enrique Aranda, Eduardo Díaz‐Rubio, Rafael López‐López, Josep Tabernero, Ana Vivancos,
The importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. However, due to delays in turnaround time, low-quality tissue samples, and/or lack of standardization of testing methods a significant proportion of patients are being treated without the information that Kirsten rat sarcoma and neuroblastoma rat sarcoma (RAS) testing can provide. The detection of mutated circulating tumor DNA by BEAMing technology ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2017 - Elsevier BV | Annals of Oncology
Fidel Antonio Castro-Smirnov, Jeanne Ayache, Jean‐Rémi Bertrand, Elodie Dardillac, Éric Le Cam, Olivier Piétrement, Pîlar Aranda, Eduardo Ruiz‐Hitzky, Bernard S. López,
Abstract Sepiolite is a nanofibrous natural silicate that can be used as a nanocarrier because it can be naturally internalized into mammalian cells, due to its nano-size dimension. Therefore, deciphering the mechanisms of sepiolite cell internalization constitutes a question interesting biotechnology, for the use of sepiolite as nanocarrier, as well as environmental and public health concerns. Though it is low, the perfectly stable and natural intrinsic fluorescence of sepiolite nanofibers allows ...
Tópico(s): Porphyrin Metabolism and Disorders
2017 - Nature Portfolio | Scientific Reports
Olivier Piétrement, Fidel Antonio Castro-Smirnov, Éric Le Cam, Pîlar Aranda, Eduardo Ruiz‐Hitzky, Bernard S. López,
Abstract Sepiolite is a nanofibrous natural silicate that can be used as a nanocarrier for DNA transfer thanks to its strong interaction with DNA molecules and its ability to be naturally internalized into mammalian cells through both non‐endocytic and endocytic pathways. Sepiolite, due to its ability to bind various biomolecules, could be a good candidate for use as a nanocarrier for the simultaneous vectorization of diverse biological molecules. In this paper, we review our recent work, issued ...
Tópico(s): Advanced Photocatalysis Techniques
2017 - Wiley | The Chemical Record
Gloria Aranda, Eduardo Fernández‐Rebollo, Marta Pradas-Juni, Felicia A. Hanzu, Susana G. Kalko, Irene Halperín, Mireia Mora,
Cross-sex hormone therapy (CHT) is critical for phenotypical and physiological transition in adults with gender dysphoria (GD). However, the impact of the CHT onto the molecular level/epigenetic regulation has not been comprehensively addressed. We postulate that CHT in GD could drive changes at the androgen receptor (AR), estrogen receptor alpha (ESR1) and estrogen receptor beta (ESR2), affecting their DNA methylation pattern and mRNA expression that may influence in the phenotypical changes associated ...
Tópico(s): Epigenetics and DNA Methylation
2017 - Elsevier BV | The Journal of Steroid Biochemistry and Molecular Biology
Amaret Sanguanwong, Adrian E. Flood, Makoto Ogawa, Raquel Martín‐Sampedro, Margarita Darder, Bernd Wicklein, Pîlar Aranda, Eduardo Ruiz‐Hitzky,
TEMPO (2,2,6,6-tetramethylpiperidin-1-oxyl)-oxidized cellulose nanofibers (CNF) were assembled to fibrous clay sepiolite (SEP) by means of a high shear homogenizer and an ultrasound treatment followed by lyophilization using three different methods: normal freezing, directional freezing, and a sequential combination of both methods. Methyltrimethoxysilane (MTMS) was grafted to the foam surface by the vapor deposition method to introduce hydrophobicity to the resulting materials. Both the SEP addition ( ...
Tópico(s): Pickering emulsions and particle stabilization
2021 - Elsevier BV | Journal of Hazardous Materials
Tonatiuh Barrientos‐Gutiérrez, Celia Alpuche‐Aranda, Eduardo Lazcano‐Ponce, Carolina Pérez‐Ferrer, Juan Á. Rivera,
El Covid-19 representa uno de los retos más grandes en la historia reciente de la salud pública. Es fundamental que se fortalezcan los lazos de cooperación científica bajo un objetivo común: proteger la salud de la población. En este artículo se presentan ideas que necesitan un desarrollo urgente y colaborativo. Se discute la estimación de la magnitud de la epidemia mediante un panel nacional de seroprevalencia y nuevas estrategias para mejorar el monitoreo en tiempo real de la epidemia. También ...
Tópico(s): Public Health and Environmental Issues
2020 - Instituto Nacional de Salud Pública | Salud Pública de México
Ediana P. Rebitski, Margarita Darder, Raffaele Carraro, Pîlar Aranda, Eduardo Ruiz‐Hitzky,
Clay–metformin intercalation compounds as a reservoir in biopolymer core–shell beads as an example of targeted controlled release systems for oral drug administration.
Tópico(s): biodegradable polymer synthesis and properties
2020 - Royal Society of Chemistry | New Journal of Chemistry
Ediana P. Rebitski, Margarita Darder, C. Ignacio Sainz‐Díaz, Raffaele Carraro, Pîlar Aranda, Eduardo Ruiz‐Hitzky,
This work introduces a comparative study on the use of two layered clays, a natural Wyoming montmorillonite (commercialized as Cloisite®Na; Mt) and a synthetic hectorite (commercialized as Laponite® XLG; Lap), to encapsulate metformin (MF), which is the most widely used oral drug for the treatment of type II diabetes. The aim was the evaluation of the suitability of the synthetic Lap clay as substrate for the controlled release of MF in comparison to the montmorillonite clay previously studied, in ...
Tópico(s): Therapeutic Uses of Natural Elements
2020 - Elsevier BV | Applied Clay Science
Nadia Boukhalfa, Margarita Darder, Mokhtar Boutahala, Pîlar Aranda, Eduardo Ruiz‐Hitzky,
Abstract Multicomponent sepiolite/magnetite/Prussian blue (PB) were prepared following the nanoarchitectonics approach by incorporating PB pigment to sepiolite fibers previously assembled with magnetite, being later encapsulated within in situ formed calcium alginate beads. These composites were characterized by diverse physicochemical techniques, showing homogeneous dispersion of the assembled nanoparticles (NP) on the surface of sepiolite fibers, the formed Ca-alginate beads exhibiting stability ...
Tópico(s): Radioactive contamination and transfer
2020 - Oxford University Press | Bulletin of the Chemical Society of Japan
Giulia Lo Dico, Bernd Wicklein, Lorenzo Lisuzzo, Giuseppe Lazzara, Pîlar Aranda, Eduardo Ruiz‐Hitzky,
Based on the unique ability of defibrillated sepiolite (SEP) to form stable and homogeneous colloidal dispersions of diverse types of nanoparticles in aqueous media under ultrasonication, multicomponent conductive nanoarchitectured materials integrating halloysite nanotubes (HNTs), graphene nanoplatelets (GNPs) and chitosan (CHI) have been developed. The resulting nanohybrid suspensions could be easily formed into films or foams, where each individual component plays a critical role in the biocomposite: ...
Tópico(s): Iron oxide chemistry and applications
2019 - Beilstein Institute for the Advancement of Chemical Sciences | Beilstein Journal of Nanotechnology
Javier Sastre, José María Viéitez, Maria Auxilidora Gomez-España, Silvia Gil Calle, Antonieta Salud Salvia, Begoña Graña, Pilar García‐Alfonso, Eva Martínez de Castro, Guillermo Alfonso Quintero Aldana, Juan José Reina-Zoilo, E. González, Mercedes Salgado Fernández, Carmen Guillén‐Ponce, Rocio García‐Carbonero, María José Safont, Adelaida La Casta Muñoa, Beatriz Paredes, Rafael López‐López, Enrique Aranda, Eduardo Díaz‐Rubio,
3507 Background: FOLFOXIRI+BEV has demonstrated a survival benefit compared with FOLFIRI plus BEV (TRIBE Lancet Oncol 2015) in first-line mCRC. Nevertheless, due to its safety profile, this schedule is not recommended for all pts. In addition, we have showed that the detection of ≥3 bCTCs is a poor prognostic factor for survival (MACRO The Oncologist 2012). The VISNU-1 trial compares FOLFOX + BEV vs FOLFOXIRI + BEV in pts with mCRC and ≥3 bCTCs. Progression-free survival (PFS) is the primary endpoint. Secondary ...
Tópico(s): Colorectal Cancer Treatments and Studies
2019 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Lorenzo Lisuzzo, Bernd Wicklein, Giulia Lo Dico, Giuseppe Lazzara, Gustavo del Real, Pîlar Aranda, Eduardo Ruiz‐Hitzky,
Multicomponent nanopaper from the assembly of nanotubular halloysite, microfibrous sepiolite and cellulose nanofibers was developed for diverse functional applications such as slow release of antibacterial model drugs loaded into halloysite lumen.
Tópico(s): Therapeutic Uses of Natural Elements
2019 - Royal Society of Chemistry | Dalton Transactions
Khaled Charradi, Zakarya Ahmed, Ricardo Escudero Cid, Pîlar Aranda, Eduardo Ruiz‐Hitzky, P. Ocón, R. Chtourou,
Nanoheterostructured material composed of sepiolite clay mineral in which is assembled a MgAl layered double hydroxide (LDH) was used in the preparation of Nafion composite electrolyte membranes and their behavior compared to those of membranes filled with the LDH alone. Both, the neat MgAl LDH and the MgAl LDH-sepiolite hybrid materials were obtained via the co-precipitation method. Sepiolite fibers provide a large external surface area for bonding MgAl LDH particles while maintaining high microporosity ...
Tópico(s): Supercapacitor Materials and Fabrication
2019 - Elsevier BV | International Journal of Hydrogen Energy
Raquel Martín‐Sampedro, María E. Eugenio, Úrsula Fillat, Juan A. Martín, Pîlar Aranda, Eduardo Ruiz‐Hitzky, David Ibarra, Bernd Wicklein,
Abstract Valorization of lignocellulosic feedstock from a Dutch elm disease tolerant Ulmus minor clone was studied as a new biomass resource. Herein, fermentable sugars and activated carbons from the side‐stream lignins were produced. For the sugar extraction organosolv and acid hydrolysis pretreatments prior to enzymatic hydrolysis were compared for the first time for this clone prior to enzymatic hydrolysis; organosolv was more efficient for delignification (49 %), while acid hydrolysis was more efficient ...
Tópico(s): Lignin and Wood Chemistry
2018 - Wiley | Energy Technology
Ana C. S. Alcântara, Margarita Darder, Pîlar Aranda, Eduardo Ruiz‐Hitzky,
Biohybrid materials based on the intercalation of zein, the major storage protein in corn, into sodium-exchanged montmorillonite were prepared following two synthesis strategies. The first one made use of zein dissolved in 80% (v/v) ethanol/water solution, the usual solvent for this protein, while the second method is new and uses a sequential process that implies the previous separation of zein components in absolute ethanol. This treatment of zein with ethanol renders a soluble yellow phase and ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2016 - Beilstein Institute for the Advancement of Chemical Sciences | Beilstein Journal of Nanotechnology
Nataša Jović-Jovičić, Zorica Mojović, Margarita Darder, Pîlar Aranda, Eduardo Ruiz‐Hitzky, Predrag Banković, Dušan Jovanović, A. Milutinović‐Nikolić,
In this paper smectite-chitosan bionanocomposite (SМ-C) based on smectite (SM) from Crni Timok (Black Timok) basin, Serbia, was synthesized and characterized using chemical analysis, XRD and FTIR. The SM-C obtained was used for the modification of a glassy carbon electrode (GCE). The modified electrode (GCE/SM-C) was tested in the electrooxidation of phenol and different nitrophenols in acidic and alkaline solutions. Cyclic voltammograms (CV) obtained for GCE/SM-C, contrary to that obtained for the bare ...
Tópico(s): Analytical Chemistry and Sensors
2016 - Elsevier BV | Applied Clay Science
Almudena Gómez‐Avilés, Pîlar Aranda, Eduardo Ruiz‐Hitzky,
This paper reports a new type of heterostructured materials based on the assembly of layered double hydroxides (LDH) to sepiolite fibrous clay. The assembly of Mg-Al and Zn-Al LDH has been explored following two procedures of synthesis: i) co-precipitation of the LDH in the presence of the clay; and ii) LDH reconstruction from the corresponding so-called "layered double oxide (LDO) phase" also in the presence of an aqueous dispersion of the clay. The resulting LDH/sepiolite nanoarchitectures were characterized ...
Tópico(s): Mesoporous Materials and Catalysis
2015 - Elsevier BV | Applied Clay Science
Ana C. S. Alcântara, Margarita Darder, Pîlar Aranda, Eduardo Ruiz‐Hitzky,
The present paper introduces results on the preparation, characterization and exploration of properties of bionanocomposites prepared by the assembly of polysaccharides to sepiolite and palygorskite. The effect of the incorporation of these fibrous clay minerals was analyzed in three types of polysaccharide matrices: neutral, such as starch, and provided with either negatively or positively charged groups, such as alginate or chitosan, respectively. The effect of the amount of clay mineral and of ...
Tópico(s): Therapeutic Uses of Natural Elements
2014 - Elsevier BV | Applied Clay Science
Lucio Antonio Ramos-Chávez, Monserrat Sordo, Emma S. Calderón‐Aranda, Eduardo Castañeda-Saucedo, Patricia Ostrosky‐Wegman, Ma. Elena Moreno‐Godínez,
Two pyrethroids, permethrin and allethrin, are often combined for large-scale use in public health programs to control vector-borne diseases. In this study, the genotoxic potential of a commercial formulation of permethrin and allethrin was examined using cultured human peripheral blood lymphocytes (PBL). Genotoxicity was evaluated using the cytokinesis-block micronucleus cytome (CBMN cyt) assay by measuring the frequency of micronuclei (MN), nuclear division index (NDI), formation of nucleoplasmic ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2014 - Taylor & Francis | Journal of Toxicology and Environmental Health
Margarita Darder, Yorexis González, Pîlar Aranda, Eduardo Ruiz‐Hitzky,
Multifunctional nanostructured materials with superparamagnetic and adsorbent properties towards cesium ions were developed by a simple procedure consisting of the one-pot synthesis of magnetite and Prussian blue nanoparticles (NPs) in the presence of a porous inorganic solid that acts as a support or nanoplatform simultaneously assembling both types of NPs. Sepiolite, a hydrated magnesium silicate with fibrous morphology, microporosity, large specific surface area and bearing hydroxyl groups in ...
Tópico(s): Covalent Organic Framework Applications
2014 - Royal Society of Chemistry | RSC Advances
Javier Sastre, Marta Vidaurreta, Auxiliadora Gómez, Fernando Rivera, Bartomeu Massutí, Margarita Reboredo López, Albert Abad, Manuel Gallén, Manuel Benavides, Enrique Aranda, Eduardo Díaz‐Rubio,
Circulating tumor cells (CTCs) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) status were identified as prognostic factors for progression-free survival (PFS) and overall survival (OS) in patients with metastatic colorectal cancer treated with chemotherapy and bevacizumab in analyses of the MACRO (Maintenance Treatment in Advanced Colorectal Cancer) trial. In this post hoc analysis of the MACRO trial, the potential additive effect of these 2 factors on patient outcomes was explored.A ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2013 - Elsevier BV | Clinical Colorectal Cancer
Cristina Ruiz‐García, Margarita Darder, Pîlar Aranda, Eduardo Ruiz‐Hitzky,
Within the many contributions in relation to the preparation and applications of graphene, this article tries to offer a new perspective on the efforts toward the exploration of alternative routes that could make possible the chemical production of graphenes in a green context. In this way, it is discussed how the use of organic molecules from natural origin offers good opportunities but, in general, it requires the use of convenient supports for the generation of the desired graphene-like materials. ...
Tópico(s): Covalent Organic Framework Applications
2013 - Royal Society of Chemistry | Journal of Materials Chemistry A
Bernd Wicklein, Pîlar Aranda, Eduardo Ruiz‐Hitzky, Margarita Darder,
Hierarchically structured polymer–clay foams comprised of sepiolite and polyvinyl alcohol (PVA) are functionalized with enzymatic and conductive properties to be employed as bioreactors and 3D bioelectrodes. The concept of nanoarchitectonics was followed in the design of this hierarchical and multifunctional cellular material through tailoring of the properties at different length scales, interfacial properties of the sepiolite fibres through adsorption of lipid molecules, bioactivity by supramolecular ...
Tópico(s): Bone Tissue Engineering Materials
2013 - Royal Society of Chemistry | Journal of Materials Chemistry B