Cèsar Sepùlveda, Iván Palomo, Eduardo Fuentes,
The adenosine A2b receptor is a G-protein coupled receptor. Its activation occurs with high extracellular adenosine concentration, for example in inflammation or hypoxia. These conditions are generated in the tumor environment. Studies show that A2b receptor is overexpressed in various tumor lines and biopsies from patients with different cancers. This suggests that A2b receptor can be used by tumor cells to promote progression. Thus A2b participates in different events, such as angiogenesis and ...
Tópico(s): Receptor Mechanisms and Signaling
2016 - Elsevier BV | Life Sciences
Cèsar Sepùlveda, Iván Palomo, Eduardo Fuentes,
Life expectancy has increased in many countries as a result the world's population is aging. The projections indicate that the proportion of the elderly in a few decades will increase significantly. Aging carries with it a series of physiological changes; one of them is an imbalance in the hemostatic system. Thus the levels or activity of various proteins involved, such as most coagulation factors, natural anticoagulants and the fibrinolytic system are altered so that the hemostatic balance leans ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
2015 - Elsevier BV | Mechanisms of Ageing and Development
Lyanne Rodríguez, Andrea Plaza, Diego Méndez, Basilio Carrasco, Francisca Tellería, Iván Palomo, Eduardo Fuentes,
Phaseolus vulgaris L. has beneficial effects on several chronic non-communicable diseases (e.g., cardiovascular diseases) related to oxidative stress. This redox state may influence platelet activation and aggregation; which is crucial in thrombus formation. In this work, the antiplatelet and antioxidant potential of aqueous extracts obtained by green processes, microwave-assisted extraction and ultrasound-assisted extraction, from 25 landraces of common beans were investigated. Phenol content and ...
Tópico(s): Essential Oils and Antimicrobial Activity
2022 - Multidisciplinary Digital Publishing Institute | Plants
Carolina Reyes-Palomo, Eduardo Aguilera, Mireia Llorente, Cipriano Díaz-Gaona, Gerardo Moreno, Vicente Rodríguez‐Estévez,
The contribution of cattle production to climate change is increasingly recognized, and there is a need to identify those systems minimizing emissions and maximizing carbon (C) sinks. In the Southwest of the Iberian Peninsula, cattle are produced on dehesa agroforestry systems, where cows and calves graze together until weaning, and calf fattening is based on external feed. The aim of this study was to assess the Carbon footprint (CF) of beef of this extensive production system using Life Cycle Assessment ( ...
Tópico(s): Forest Management and Policy
2022 - Elsevier BV | Journal of Cleaner Production
Magdalena Sepúlveda, Diego Arauna, Francisco J. García‐García, Cecilia Albala, Iván Palomo, Eduardo Fuentes,
In the context of accelerated aging of the population worldwide, frailty has emerged as one of the main risk factors that can lead to loss of self-sufficiency in older people. This syndrome is defined as a reduced state of physiological reserve and functional capacity. The main diagnostic tools for frailty are based on scales that show deficits compared to their clinical application, such as the Fried frailty phenotype, among others. In this context, it is important to have one or more biomarkers ...
Tópico(s): GDF15 and Related Biomarkers
2022 - Multidisciplinary Digital Publishing Institute | Biomedicines
Lyanne Rodríguez, Diego Méndez, Héctor Montecino-Garrido, Basilio Carrasco, Bárbara Arévalo, Iván Palomo, Eduardo Fuentes,
In terms of safe and healthy food, beans play a relevant role. This crop belongs to the species of
Tópico(s): Natural Antidiabetic Agents Studies
2022 - Multidisciplinary Digital Publishing Institute | Plants
Inmaculada Carmen Lara‐Palomo, Eduardo Antequera-Soler, Guillermo A. Matarán-Peñarrocha, Manuel Fernández-Sánchez, Héctor García‐López, Adelaida María Castro‐Sánchez, María Encarnación Aguilar‐Ferrándiz,
We conducted a randomized double blind clinical trial, to compare the effectiveness of McKenzie exercises and electroanalgesia via an e-Health program versus a home rehabilitation program on functionality, pain, fear of movement and quality of life in patients with non-specific chronic low back pain.Seventy-four participants with non-specific chronic low back pain were randomized to either the e- Health program group (n = 39) or the home rehabilitation program group (n = 35). The interventions consisted ...
Tópico(s): Pain Management and Treatment
2022 - SAGE Publishing | Digital Health
Miguel Díaz‐Sánchez, Patricia Reñones, Irene Mena-Palomo, Eduardo López‐Collazo, Fernando Fresno, F. Palacio, Sanjiv Prashar, Víctor A. de la Peña O’Shea, Santiago Gómez‐Ruiz,
Ionic liquid (IL) assisted syntheses of ultrareactive F-doped mesoporous aggregates of titanium dioxide nanoparticles have been studied using different synthetic methods in order to obtain non-toxic, highly versatile systems able to combine the high photocatalytic activity of the F-doping with a high surface area, to be applied in different catalytic and photocatalytic processes of environmental interest. The synthesized materials were characterized by various techniques, showing that they consist ...
Tópico(s): Polyoxometalates: Synthesis and Applications
2021 - Elsevier BV | Applied Catalysis A General
Lyanne Rodríguez, Lina Badimón, Diego Méndez, Teresa Padró, Gemma Vilahur, Esther Peña, Basilio Carrasco, H. Vogel, Iván Palomo, Eduardo Fuentes,
With the diet, we ingest nutrients capable of modulating platelet function, which plays a crucial role in developing cardiovascular events, one of the leading causes of mortality worldwide. Studies that demonstrate the antiplatelet and antithrombotic potential of bioactive compounds are vital to maintaining good cardiovascular health. In this work, we evaluate the flavonol isorhamnetin’s antiplatelet effect on human platelets, using collagen, thrombin receptor activator peptide 6 (TRAP-6), and phorbol ...
Tópico(s): Medicinal plant effects and applications
2021 - Multidisciplinary Digital Publishing Institute | Antioxidants
Guillermo A. Matarán-Peñarrocha, Inmaculada Carmen Lara‐Palomo, Eduardo Antequera Soler, Esther Gil-Martínez, Manuel Fernández-Sánchez, María Encarnación Aguilar‐Ferrándiz, Adelaida María Castro‐Sánchez,
Objective: To compare the effectiveness of supervised physical therapy program versus non-supervised on pain, functionality, fear of movement and quality of life in patients with non-specific chronic low back pain. Design: A randomized double-blind clinical trial. Setting: Clinical outpatient unit; home. Subjects: A total of 64 participants with non-specific chronic low back pain were randomized into either supervised exercise group ( n = 32) or non-supervised home exercise group ( n = 32). Interventions: ...
Tópico(s): Spine and Intervertebral Disc Pathology
2020 - SAGE Publishing | Clinical Rehabilitation
Diego Arauna, Francisco J. García‐García, Leocadio Rodríguez‐Mañas, Jaume Marrugat, Claudia G. Sáez, Marcelo Alarcón, Sergio Wehinger, Yolanda Espinosa‐Parrilla, Iván Palomo, Eduardo Fuentes,
The elderly population is increasing worldwide and in Chile, it is expected to grow rapidly. The World Health Organization (WHO) ICOPE guideline (Integrated Care for Older People) emphasizes the importance of frailty diagnosis to prevent dependence. Frailty in older adults is considered an indicator of vulnerability and poor health outcomes, of multifactorial etiology. Our objective was to investigate the association of activation of coagulation and increased risk of thrombosis with frailty in people ...
Tópico(s): Frailty in Older Adults
2020 - Elsevier BV | Free Radical Biology and Medicine
Manuel Durán Fuentes, Ramiro Araya‐Maturana, Iván Palomo, Eduardo Fuentes,
Platelet mitochondrial dysfunction has been identified in different diseases. Platelet mitochondrial dysfunction favors platelet activation with a considerable increase in oxidative stress, which is implicated in platelet non-responsiveness to current antiplatelet therapy. The inhibition of platelet mitochondrial dysfunction could potentially be used as a new strategy for the development of antiplatelet activity drugs. In this context, we described quinone and hydroquinone derivatives and mitochondrially ...
Tópico(s): Nitric Oxide and Endothelin Effects
2018 - Elsevier BV | Biochemical Pharmacology
Eva Céspedes, Adrián Rodríguez-Palomo, Eduardo Salas‐Colera, Emiliano Fonda, F. Jiménez‐Villacorta, M. Vila, A. de Andrés, C. Prieto,
Enhancing the stability of spectrally selective coatings (SSC) at high temperatures in air is necessary to push the concentrated solar power (CSP) technology to the next level. To avoid failures that might not be discovered for years, advanced knowledge of the chemical properties related to the degradation mechanisms with temperature is required. For this purpose, the Mo local environment is investigated here for Mo–Si3N4 and MoSi2–Si3N4 nanocomposites SSCs. The atomic short-range order around Mo ...
Tópico(s): Silicon and Solar Cell Technologies
2018 - American Chemical Society | ACS Applied Energy Materials
BERNARDITA MONSALVE, Aníbal Concha‐Meyer, Iván Palomo, Eduardo Fuentes,
The endothelium is fundamental for the regulation of vascular tone and structure. Under disease conditions, including the presence of cardiovascular disease risk factors, the endothelium loses its protective role and becomes a proatherosclerotic structure. In this article we searched for strategies from PUBMED and Science Direct databases using the following key words: endothelium, natural bioactive compounds, polyphenols and cardiovascular diseases. The search was restricted to english language ...
Tópico(s): Cholesterol and Lipid Metabolism
2017 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências
Francisco Fuentes, Iván Palomo, Eduardo Fuentes,
The average lifespan of humans and the percentage of people entering the 65 and older age group are growing rapidly. Within this age group, cardiovascular diseases (CVD) increase steeply and are the most common cause of death. During aging, experimental and clinical studies support the pivotal role played by reactive oxidant species in the mechanism of platelet activation. Frailty has been implicated as a causative and prognostic factor in patients with CVD. Oxidative stress is increased in frail ...
Tópico(s): Peripheral Artery Disease Management
2017 - Elsevier BV | Vascular Pharmacology
Francisco Fuentes, Marcelo Alarcón, Lina Badimón, Manuel Durán Fuentes, Karl‐Norbert Klotz, Gemma Vilahur, Sonja Kachler, Teresa Padró, Iván Palomo, Eduardo Fuentes,
Guanosine is a natural product and an endogenous nucleoside that has shown to increase during myocardial ischemia. Platelets are critically involved in ischemic coronary events. It remains unknown, however, whether guanosine may affect platelet activation and function. We sought to investigate the potential antiplatelet and antithrombotic properties of guanosine and decipher the mechanisms behind.We firstly assessed the effects of guanosine on platelet activation/aggregation upon stimulation with ...
Tópico(s): Adenosine and Purinergic Signaling
2017 - Elsevier BV | International Journal of Cardiology
Cèsar Sepùlveda, Iván Palomo, Eduardo Fuentes,
One of the risk factors for developing cardiovascular disease (CVD) is aging. In the elderly endothelial dysfunction occurs as altered endothelial ability to regulate hemostasis, vascular tone and cell permeability. In addition, there are changes in the expression and plasma levels of important endothelial components related to endothelial-mediated modulation in hemostasis. These include alterations in the metabolism of nitric oxide and prostanoides, endothelin-1, thrombomodulin and Von Willebrand ...
Tópico(s): Sodium Intake and Health
2017 - Elsevier BV | Mechanisms of Ageing and Development
Iván Palomo, Eduardo Fuentes, Teresa Padró, Lina Badimón,
In recent years, it has been shown that platelets are not only involved in the arterial thrombotic process, but also that they play an active role in the inflammatory process of atherogenesis from the beginning. The interaction between platelets and endothelial cells occurs in two manners: activated platelets unite with intact endothelial cells, or platelets in resting adhere to activated endothelium. In this context, inhibition of the platelet function (adhesion/aggregation) could contribute to ...
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2012 - Spandidos Publishing | Experimental and Therapeutic Medicine
Ilse Decordier, Alexandre Papine, G. Plas, S. Roesems, Kim Vande Loock, Jennifer Moreno-Palomo, Eduardo Cemeli, Diana Anderson, Aleksandra Fučić, Ricard Marcos, F. Soussaline, Micheline Kirsch‐Volders,
Micronuclei (MN) frequencies in peripheral blood lymphocytes have been used worldwide as a biomarker of chromosomal damage for genotoxicity testing and biomonitoring studies. Automation of MN analysis would provide faster and more reliable results with minimizing subjective MN identification. We developed an automated facility for the scoring of the in vitro MN cytokinesis-block assay for biomonitoring on Giemsa-stained slides, fulfilling the following criteria: applicable to the cytokinesis-block ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2008 - Oxford University Press | Mutagenesis
Andrea Plaza, Lyanne Rodríguez, Aníbal Concha‐Meyer, R. Cabezas, Elsie Zurob, Gastón Merlet, Iván Palomo, Eduardo Fuentes,
Aqueous and ethanolic extracts of tomato pomace were examined with the aim of optimizing the extraction process of compounds with cardioprotective activity. Once the results of the ORAC response variables, total polyphenols, °Brix, and antiplatelet activity of the extracts were obtained, a multivariate statistical analysis was performed using the Statgraphics Centurion XIX software. This analysis showed that the most relevant positive effects in the inhibition of platelet aggregation were 83 ± 2% when ...
Tópico(s): Essential Oils and Antimicrobial Activity
2023 - Multidisciplinary Digital Publishing Institute | Plants
Cèsar Sepùlveda, Iván Palomo, Eduardo Fuentes,
Beyond its function in hemostasis, platelets activation has an important role in cardiovascular diseases (CVD) development. There are different clinical conditions that can mediate abnormal platelet activation and favors pathological thrombosis and CVD. These include Hypertension, diabetes and dyslipidemia, all risks factors from CVD development. Different drugs employed in the handled of these conditions have showed decreases platelet activation and related markers. This effect is in part by improved ...
Tópico(s): Diabetes Treatment and Management
2017 - Elsevier BV | Vascular Pharmacology
Pablo Pánico, Myrian Velasco, Ana María Salazar, Arturo Picones, Rosa Isela Ortiz-Huidobro, Gabriela Guerrero‐Palomo, Manuel Eduardo Salgado-Bernabé, Patricia Ostrosky‐Wegman, Marcia Hiriart,
Exposure to arsenic in drinking water is a worldwide health problem. This pollutant is associated with increased risk of developing chronic diseases, including metabolic diseases. Metabolic syndrome (MS) is a complex pathology that results from the interaction between environmental and genetic factors. This condition increases the risk of developing type 2 diabetes, cardiovascular diseases, and cancer. The MS includes at least three of the following signs, central obesity, impaired fasting glucose, ...
Tópico(s): Dye analysis and toxicity
2022 - Frontiers Media | Frontiers in Endocrinology
Xavier Querol, Andrés Alástuey, Teresa Moreno, Mar Viana, Sonia Castillo, Jorge Pey, Sergio Rodrı́guez, Begoña Artı́ñano, Pedro Salvador, M. Sánchez, Saúl García dos Santos, M. D. Herce Garraleta, Rosalía Fernández-Patier, Stella Moreno‐Grau, L. Negral, María Cruz Minguillón, E. Monfort, María José Sanz, Rosario Palomo-Marín, Eduardo Pinilla Gil, Emilio Cuevas, Jesús de la Rosa, Ana M. Sánchez de la Campa,
Average ranges of particulate matter (PM10 and PM2.5) concentrations and chemical composition in Spain show significant variations across the country, with current PM10 levels at several industrial and traffic hotspots exceeding recommended pollution limits. Such variations and exceedances are linked to patterns of anthropogenic and natural PM emissions, climate, and reactivity/stability of particulate species. PM10 and PM2.5 concentrations reach 14–22 μg PM10 m−3 and 8–12 μg PM2.5 m−3 at most rural/ ...
Tópico(s): Vehicle emissions and performance
2006 - Elsevier BV | Atmospheric Environment
David Cargua-Sagbay, Eduardo Palomo-Lema, Óscar Camacho, Hernán Álvarez,
The aim of this work is to develop a sliding mode control scheme to keep the operation of a flash distiller in the feasible operating region. Flash distillation is characterized as a simple single-phase separation system but operationally complex because it has a strong nonlinear behavior due to the thermodynamic equilibrium, obligatory to reach the required component separation. Control of flash distillation processes must guarantee a good performance and robustness to achieve preseparation quality ...
Tópico(s): Advanced Control Systems Design
2020 - American Chemical Society | Industrial & Engineering Chemistry Research
Ma Rosario Palomo Marín, Eduardo Pinilla Gil, Lorenzo Calvo Blázquez, José Luís Capelo,
A simple, fast and miniaturized ultrasonic probe assisted protocol for acid extraction of trace and major elements from street dust samples, prior to final determination by ICP-MS, has been optimized and validated by standard reference materials and applied during an urban air quality monitoring campaign. 15 mg samples were treated for 3 min with 1 mL concentrated HNO3–HCl (1:3, v/v) extracting solution, by a 1 mm diameter titanium sonotrode connected to a 200 W and 24 kHz ultrasonic device at 80% ...
Tópico(s): Heavy metals in environment
2011 - Elsevier BV | Talanta
Manuel Durán Fuentes, Cèsar Sepùlveda, Marcelo Alarcón, Iván Palomo, Eduardo Fuentes,
Platelets play a key role in thrombosis and cardiovascular diseases. Medicinal plants could be one of the most important factors that influence risks for platelet activation. Buddleja globosa (known as "matico") is a medicinal plant with many biological activities. The high content of polyphenols suggest that matico could have antiplatelet activity. The present study was aimed at evaluating mechanisms of antiplatelet action of an extract of matico. We demonstrated that matico extract at low concentrations ...
Tópico(s): Natural product bioactivities and synthesis
2017 - Elsevier BV | Journal of Traditional and Complementary Medicine
Silvia Palomo‐Piñón, Neftali Eduardo Antonio‐Villa, Luis Rey García‐Cortés, Cleto Álvarez‐Aguilar, Esteban González‐Palomo, Olga Margarita Bertadillo‐Mendoza, María Eugenia Figueroa‐Suárez, Francisco Vargas Hernández, Imer Guillermo Herrera‐Olvera, Jairo Enoc Cruz‐Toledo, Maria Adriana Cruz‐Arce, Berenice Serafín‐Méndez, Gerardo Muñoz‐Cortés, Claudia Janeth Morfin‐Macias,
Abstract Arterial hypertension is considered a public health problem with severe consequences at an individual and public health levels. However, there is a lack of information regarding its characterization in Mexico. The objective of this study is to estimate the proportion of undiagnosed arterial hypertension (UAH) and the overall prevalence and clinical management of arterial hypertension within the Eastern Zone of Mexico. Additionally, we explore associated factors related with both UAH and ...
Tópico(s): Sodium Intake and Health
2021 - Wiley | Journal of Clinical Hypertension
Iván Palomo, Eduardo Fuentes, Gilda Carrasco, Daniel R. González, Rodrigo Moore‐Carrasco,
INTRODUCCIÓNLas enfermedades no transmisibles (ENT), entre las que se encuentran las enfermedades cardiovasculares (ECV), representan un problema de salud pública a nivel mundial (1, 2).Las ECV (infarto agudo de miocardio, enfermedad cerebro vascular y trombosis arterial periférica) desde el punto de vista patogénico, se inician por un proceso aterotrombótico (3), en el cual el endotelio (4),
Tópico(s): Phytochemicals and Antioxidant Activities
2010 - | Revista chilena de nutrición
Ma Rosario Palomo Marín, Eduardo Pinilla Gil, Lorenzo Calvo Blázquez,
Abstract Cd and Pb determination in ambient aerosol samples based on SWASV at a Bi film glassy carbon electrode is described. Extremely acid solutions resulting from sample digestion were directly assayed, with sufficient detection limits for testing the fulfilment of air quality regulations. Accuracy was tested on NIST Standard Reference Materials and real aerosol samples, with good recoveries for Pb comparable to ICP‐MS results. Cd was not detected, probably due to the combined effects of low ...
Tópico(s): Analytical Chemistry and Sensors
2010 - Wiley | Electroanalysis
Nicolás Lillo, Gonzalo Palomo‐Vélez, Eduardo Fuentes, Iván Palomo,
Tópico(s): Cardiac Health and Mental Health
2015 - Springer Science+Business Media | Sport Sciences for Health